SYNE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)8.37542330
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.31079667
3protein retention in ER lumen (GO:0006621)8.00236313
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.24325023
5intestinal cholesterol absorption (GO:0030299)6.24003142
6nucleotide transmembrane transport (GO:1901679)5.80700833
7endocrine pancreas development (GO:0031018)5.51752905
8digestion (GO:0007586)5.34238382
9signal peptide processing (GO:0006465)5.32588488
10glandular epithelial cell differentiation (GO:0002067)5.14015950
11COPII vesicle coating (GO:0048208)5.05738082
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.04892873
13water-soluble vitamin biosynthetic process (GO:0042364)5.01492208
14proline biosynthetic process (GO:0006561)4.98995155
15GDP-mannose metabolic process (GO:0019673)4.87147082
16positive regulation of nuclease activity (GO:0032075)4.81836134
17protein maturation by protein folding (GO:0022417)4.72087723
18peptide catabolic process (GO:0043171)4.62343443
19regulation of nuclease activity (GO:0032069)4.39552712
20intestinal epithelial cell development (GO:0060576)4.34048227
21endoplasmic reticulum unfolded protein response (GO:0030968)4.29052321
22behavioral response to nicotine (GO:0035095)4.23323982
23peptide hormone processing (GO:0016486)4.21132215
24cellular response to unfolded protein (GO:0034620)4.20287226
25vesicle coating (GO:0006901)4.11190374
26ER-nucleus signaling pathway (GO:0006984)4.10992226
27cellular ketone body metabolic process (GO:0046950)4.09574820
28cellular response to topologically incorrect protein (GO:0035967)4.09153790
29regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.07058129
30response to endoplasmic reticulum stress (GO:0034976)3.98758954
31transcytosis (GO:0045056)3.97491803
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.85091116
33proline metabolic process (GO:0006560)3.82591067
34renal absorption (GO:0070293)3.68663249
35intra-Golgi vesicle-mediated transport (GO:0006891)3.66560473
36purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.65814852
373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.65814852
38ER overload response (GO:0006983)3.61529141
39zinc ion transport (GO:0006829)3.60555575
40intestinal absorption (GO:0050892)3.59666263
41ketone body metabolic process (GO:1902224)3.57507496
42regulation of apoptotic process involved in morphogenesis (GO:1902337)3.55976131
43protein N-linked glycosylation via asparagine (GO:0018279)3.55618290
44peptidyl-asparagine modification (GO:0018196)3.54255961
45nephron epithelium morphogenesis (GO:0072088)3.54189690
46nephron tubule morphogenesis (GO:0072078)3.54189690
474-hydroxyproline metabolic process (GO:0019471)3.52015664
48L-alpha-amino acid transmembrane transport (GO:1902475)3.50416880
49negative regulation of digestive system process (GO:0060457)3.50014001
50regulation of type B pancreatic cell apoptotic process (GO:2000674)3.48284277
51respiratory chain complex IV assembly (GO:0008535)3.47942655
52regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.47398449
53positive regulation of insulin secretion (GO:0032024)3.46921750
54columnar/cuboidal epithelial cell development (GO:0002066)3.45468260
55protein complex biogenesis (GO:0070271)3.41010750
56response to unfolded protein (GO:0006986)3.36702834
57mannosylation (GO:0097502)3.33924365
58maintenance of protein localization in organelle (GO:0072595)3.30018137
59mitochondrial respiratory chain complex assembly (GO:0033108)3.28576155
60lactate metabolic process (GO:0006089)3.28259539
61response to topologically incorrect protein (GO:0035966)3.28158980
62DNA deamination (GO:0045006)3.26951197
63fucose catabolic process (GO:0019317)3.25822754
64L-fucose metabolic process (GO:0042354)3.25822754
65L-fucose catabolic process (GO:0042355)3.25822754
66protein N-linked glycosylation (GO:0006487)3.24468966
67cytochrome complex assembly (GO:0017004)3.22347397
68pharyngeal system development (GO:0060037)3.19479486
69negative regulation of glycoprotein biosynthetic process (GO:0010561)3.18881028
70nucleotide transport (GO:0006862)3.18169669
71poly(A)+ mRNA export from nucleus (GO:0016973)3.17612323
72negative regulation of telomere maintenance (GO:0032205)3.15945620
73histone H4-K12 acetylation (GO:0043983)3.15232596
74preassembly of GPI anchor in ER membrane (GO:0016254)3.12370834
75response to nitrosative stress (GO:0051409)3.11891617
76signal transduction involved in regulation of gene expression (GO:0023019)3.09976177
77indolalkylamine metabolic process (GO:0006586)3.08755538
78peptidyl-proline hydroxylation (GO:0019511)3.07787134
79sequestering of metal ion (GO:0051238)3.07652828
80positive regulation of receptor biosynthetic process (GO:0010870)3.04595369
81valine metabolic process (GO:0006573)3.03306772
82epithelial cell fate commitment (GO:0072148)3.01392622
83UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01325571
84regulation of cholesterol biosynthetic process (GO:0045540)3.00851793
85kynurenine metabolic process (GO:0070189)2.99924334
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.98898048
87NADH dehydrogenase complex assembly (GO:0010257)2.98898048
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98898048
89nucleotide-sugar biosynthetic process (GO:0009226)2.98470824
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.98375802
91protein autoprocessing (GO:0016540)2.95940788
92glandular epithelial cell development (GO:0002068)2.94080435
93xenobiotic catabolic process (GO:0042178)2.91814253
94regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.91627734
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91141624
96indole-containing compound catabolic process (GO:0042436)2.90116298
97indolalkylamine catabolic process (GO:0046218)2.90116298
98tryptophan catabolic process (GO:0006569)2.90116298
99nucleotide-sugar metabolic process (GO:0009225)2.87540468
100kidney morphogenesis (GO:0060993)2.86250339
101pteridine-containing compound biosynthetic process (GO:0042559)2.85175277
102positive regulation of peptide hormone secretion (GO:0090277)2.83622041
103branched-chain amino acid metabolic process (GO:0009081)2.81223347
104cobalamin metabolic process (GO:0009235)2.80757007
105hormone catabolic process (GO:0042447)2.79797589
106pancreas development (GO:0031016)2.79681585
107cellular response to glucose starvation (GO:0042149)2.79480161
108ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.79247608
109cell redox homeostasis (GO:0045454)2.78614746
110regulation of insulin secretion (GO:0050796)2.78588153
111pseudouridine synthesis (GO:0001522)2.77713407
112regulation of glucokinase activity (GO:0033131)2.77102292
113regulation of hexokinase activity (GO:1903299)2.77102292
114branched-chain amino acid catabolic process (GO:0009083)2.76205369
115DNA double-strand break processing (GO:0000729)2.74805847
116protein hydroxylation (GO:0018126)2.72753969
117detection of light stimulus involved in sensory perception (GO:0050962)2.72565357
118detection of light stimulus involved in visual perception (GO:0050908)2.72565357
119ATP synthesis coupled proton transport (GO:0015986)2.71876212
120energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71876212
121positive regulation of peptide secretion (GO:0002793)2.70418735
122sulfur amino acid catabolic process (GO:0000098)2.70325167
123insulin secretion (GO:0030073)2.68228035
124nucleoside transmembrane transport (GO:1901642)2.67708812
125pyrimidine-containing compound transmembrane transport (GO:0072531)2.65954144
126mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.62393222
127regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62245139
128regulation of cardioblast proliferation (GO:0003264)2.62245139
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61425127
130protein-cofactor linkage (GO:0018065)2.61112473
131peptide metabolic process (GO:0006518)2.60406858
132regulation of mitochondrial translation (GO:0070129)2.60068954
133ER to Golgi vesicle-mediated transport (GO:0006888)2.60025868
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59601287
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59601287
136cysteine metabolic process (GO:0006534)2.59289692
137ubiquinone biosynthetic process (GO:0006744)2.58976707
138cornea development in camera-type eye (GO:0061303)2.58829429
139biotin metabolic process (GO:0006768)2.58275236
140aromatic amino acid family catabolic process (GO:0009074)2.57891255
141growth hormone secretion (GO:0030252)2.57472120
142rRNA modification (GO:0000154)2.56451092
143piRNA metabolic process (GO:0034587)2.56070266
144polyol catabolic process (GO:0046174)2.55344558
145DNA methylation involved in gamete generation (GO:0043046)2.54507798
146axoneme assembly (GO:0035082)2.53956403
147peptidyl-histidine modification (GO:0018202)2.53938945
148protein localization to cilium (GO:0061512)2.53429948
149protein K6-linked ubiquitination (GO:0085020)2.53419649
150regulation of hippo signaling (GO:0035330)2.52908571
151glycerophospholipid catabolic process (GO:0046475)2.51679608
152S-adenosylmethionine metabolic process (GO:0046500)2.49543546
153electron transport chain (GO:0022900)2.49046388
154ubiquinone metabolic process (GO:0006743)2.48702933
155dopamine transport (GO:0015872)2.47785022
156indole-containing compound metabolic process (GO:0042430)2.46588258
157vitamin biosynthetic process (GO:0009110)2.46293023
158tryptophan metabolic process (GO:0006568)2.46187663
159GPI anchor metabolic process (GO:0006505)2.46014877
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44607899
161serotonin metabolic process (GO:0042428)2.44238127
162inositol phosphate catabolic process (GO:0071545)2.43898331
163inositol phosphate dephosphorylation (GO:0046855)2.43468196
164phosphorylated carbohydrate dephosphorylation (GO:0046838)2.43468196
165negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43206436
166negative regulation of translation, ncRNA-mediated (GO:0040033)2.43206436
167regulation of translation, ncRNA-mediated (GO:0045974)2.43206436
168aldehyde catabolic process (GO:0046185)2.42622537
169C-terminal protein lipidation (GO:0006501)2.42191320
170primary amino compound metabolic process (GO:1901160)2.39895264
171keratinocyte development (GO:0003334)2.39220981
172amino acid salvage (GO:0043102)2.38981815
173L-methionine salvage (GO:0071267)2.38981815
174L-methionine biosynthetic process (GO:0071265)2.38981815
175epithelial cilium movement (GO:0003351)2.38741036
176rRNA methylation (GO:0031167)2.38506028
177transcription elongation from RNA polymerase III promoter (GO:0006385)2.38490401
178termination of RNA polymerase III transcription (GO:0006386)2.38490401
179respiratory electron transport chain (GO:0022904)2.37389124
180GPI anchor biosynthetic process (GO:0006506)2.36935623
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35753768
182serine family amino acid catabolic process (GO:0009071)2.35265953
183somite rostral/caudal axis specification (GO:0032525)2.33643672
184aspartate family amino acid catabolic process (GO:0009068)2.33614209
185tRNA processing (GO:0008033)2.32809267
186C-terminal protein amino acid modification (GO:0018410)2.32490275
187regulation of gene silencing by miRNA (GO:0060964)2.31603047
188Golgi transport vesicle coating (GO:0048200)10.3491723
189COPI coating of Golgi vesicle (GO:0048205)10.3491723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.94428697
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.28430217
3ZNF274_21170338_ChIP-Seq_K562_Hela4.10751674
4DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.59380973
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39063371
6VDR_22108803_ChIP-Seq_LS180_Human3.30046693
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.29181433
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.29181433
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.29181433
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89891981
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.67941603
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.57743188
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.36509351
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.31965382
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.31647629
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.26970576
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18712486
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.18059679
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16307073
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12993097
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.10640501
22IGF1R_20145208_ChIP-Seq_DFB_Human2.02937357
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.97128714
24ER_23166858_ChIP-Seq_MCF-7_Human1.93055774
25SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.89053407
26GATA6_25053715_ChIP-Seq_YYC3_Human1.85726972
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.81998360
28TP53_22573176_ChIP-Seq_HFKS_Human1.78711062
29ZNF263_19887448_ChIP-Seq_K562_Human1.77853241
30GBX2_23144817_ChIP-Seq_PC3_Human1.77496561
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76219372
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75976700
33MYC_18940864_ChIP-ChIP_HL60_Human1.75837396
34FUS_26573619_Chip-Seq_HEK293_Human1.72511076
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72144114
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.70236211
37GATA4_25053715_ChIP-Seq_YYC3_Human1.69568553
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67602843
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66978048
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66224069
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.65723000
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64184069
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60537103
44EWS_26573619_Chip-Seq_HEK293_Human1.59605488
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.58642941
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57786242
47VDR_23849224_ChIP-Seq_CD4+_Human1.57335042
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56397457
49CHD1_26751641_Chip-Seq_LNCaP_Human1.56056796
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55509184
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52885661
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.52885661
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.52063026
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50108406
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48214030
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48059524
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.47135689
58TAF15_26573619_Chip-Seq_HEK293_Human1.46331163
59BCAT_22108803_ChIP-Seq_LS180_Human1.44918420
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.44792310
61AR_20517297_ChIP-Seq_VCAP_Human1.43582759
62HOXB7_26014856_ChIP-Seq_BT474_Human1.43042312
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43026047
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40685445
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39184538
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36969161
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36330576
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35952465
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35122433
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34587185
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32999547
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.32956829
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32865665
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32663438
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31502909
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.31245055
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.30998055
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30792278
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.30503316
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30046817
81ERA_21632823_ChIP-Seq_H3396_Human1.29927252
82P300_19829295_ChIP-Seq_ESCs_Human1.29426448
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.28422799
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.27912789
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27200880
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27166767
87ELK1_19687146_ChIP-ChIP_HELA_Human1.26846297
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26487021
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24749649
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24640952
91CREB1_26743006_Chip-Seq_LNCaP_Human1.24327926
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24294141
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24235747
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24098429
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24065219
96GATA3_24758297_ChIP-Seq_MCF-7_Human1.23660068
97FOXP3_21729870_ChIP-Seq_TREG_Human1.22121544
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21618247
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20947756
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18172991
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17826037
102OCT4_20526341_ChIP-Seq_ESCs_Human1.17585385
103NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17584461
104KDM5A_27292631_Chip-Seq_BREAST_Human1.16960492
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16805411
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16634994
107REST_21632747_ChIP-Seq_MESCs_Mouse1.16627620
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15992131
109HTT_18923047_ChIP-ChIP_STHdh_Human1.15216960
110NCOR_22424771_ChIP-Seq_293T_Human1.14482204
111LXR_22158963_ChIP-Seq_LIVER_Mouse1.14384325
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14338757
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13744323
114MYC_19829295_ChIP-Seq_ESCs_Human1.13133099
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12544032
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12235773
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11615735
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.10775973
119AR_25329375_ChIP-Seq_VCAP_Human1.10199293
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10040250
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09818588
122MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09598496
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09116707
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08989606
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08976045
126NANOG_19829295_ChIP-Seq_ESCs_Human1.08154613
127SOX2_19829295_ChIP-Seq_ESCs_Human1.08154613
128MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07917687
129NANOG_20526341_ChIP-Seq_ESCs_Human1.07779566
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06545207
131CIITA_25753668_ChIP-Seq_RAJI_Human1.06459790
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06458513
133TCF4_22108803_ChIP-Seq_LS180_Human1.05595631
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03861487
135FOXA1_25552417_ChIP-Seq_VCAP_Human1.03735570
136RUNX1_27514584_Chip-Seq_MCF-7_Human1.02704240
137P53_21459846_ChIP-Seq_SAOS-2_Human1.01895678
138THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01708518
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01349190
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01104519
141RACK7_27058665_Chip-Seq_MCF-7_Human1.00817769
142NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00556598
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99214493
144TP63_19390658_ChIP-ChIP_HaCaT_Human0.98186506
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.97889070
146GABP_19822575_ChIP-Seq_HepG2_Human0.97315044
147SOX2_20726797_ChIP-Seq_SW620_Human0.97044938
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95296432
149TAF2_19829295_ChIP-Seq_ESCs_Human0.94553992
150CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93791261
151NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93623470
152IRF1_19129219_ChIP-ChIP_H3396_Human0.93605352
153EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93240462
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92884242
155HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92606593
156CDX2_22108803_ChIP-Seq_LS180_Human0.92444311
157CBP_20019798_ChIP-Seq_JUKART_Human0.91892192
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91892192
159DCP1A_22483619_ChIP-Seq_HELA_Human0.91780508
160RUNX2_22187159_ChIP-Seq_PCA_Human0.91684901
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.91641889
162ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91561644
163BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90872516
164TCF4_23295773_ChIP-Seq_U87_Human0.90838919
165TFEB_21752829_ChIP-Seq_HELA_Human0.90567697
166ATF3_27146783_Chip-Seq_COLON_Human0.90447796
167FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89941267
168STAT3_23295773_ChIP-Seq_U87_Human0.89506791
169POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89374784
170KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88906868
171FOXP1_21924763_ChIP-Seq_HESCs_Human0.88747154
172SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88593549
173REST_18959480_ChIP-ChIP_MESCs_Mouse0.88082621
174KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87778705
175SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87575879
176SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86295783
177RAC3_21632823_ChIP-Seq_H3396_Human0.85811223
178UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85296990
179NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85256071
180FOXH1_21741376_ChIP-Seq_EPCs_Human0.85146957
181KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82370735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005220_abnormal_exocrine_pancreas4.61955148
2MP0004043_abnormal_pH_regulation4.10255835
3MP0002877_abnormal_melanocyte_morpholog3.70818567
4MP0001666_abnormal_nutrient_absorption3.62062433
5MP0005083_abnormal_biliary_tract3.54527723
6MP0008877_abnormal_DNA_methylation3.50484089
7MP0003787_abnormal_imprinting3.37698190
8MP0000678_abnormal_parathyroid_gland3.37013437
9MP0004264_abnormal_extraembryonic_tissu3.36151508
10MP0003183_abnormal_peptide_metabolism3.30489704
11MP0005365_abnormal_bile_salt3.00330208
12MP0001944_abnormal_pancreas_morphology2.98155501
13MP0002693_abnormal_pancreas_physiology2.81694241
14MP0003283_abnormal_digestive_organ2.66351290
15MP0002254_reproductive_system_inflammat2.61033515
16MP0009780_abnormal_chondrocyte_physiolo2.58855451
17MP0003011_delayed_dark_adaptation2.18522012
18MP0003195_calcinosis2.14435972
19MP0005551_abnormal_eye_electrophysiolog2.13716189
20MP0005084_abnormal_gallbladder_morpholo2.08340277
21MP0001968_abnormal_touch/_nociception2.06653233
22MP0008789_abnormal_olfactory_epithelium2.03064029
23MP0000013_abnormal_adipose_tissue2.02822526
24MP0000613_abnormal_salivary_gland1.86883889
25MP0003123_paternal_imprinting1.83839232
26MP0010386_abnormal_urinary_bladder1.81803579
27MP0006072_abnormal_retinal_apoptosis1.81631626
28MP0005499_abnormal_olfactory_system1.81286493
29MP0005394_taste/olfaction_phenotype1.81286493
30MP0002909_abnormal_adrenal_gland1.81162906
31MP0002736_abnormal_nociception_after1.80095626
32MP0010234_abnormal_vibrissa_follicle1.75703094
33MP0002653_abnormal_ependyma_morphology1.74042856
34MP0002139_abnormal_hepatobiliary_system1.65801338
35MP0002163_abnormal_gland_morphology1.61853555
36MP0008872_abnormal_physiological_respon1.61039656
37MP0009643_abnormal_urine_homeostasis1.60075582
38MP0000003_abnormal_adipose_tissue1.59737308
39MP0000427_abnormal_hair_cycle1.54980368
40MP0005379_endocrine/exocrine_gland_phen1.54572755
41MP0006292_abnormal_olfactory_placode1.53978327
42MP0009046_muscle_twitch1.53636165
43MP0002078_abnormal_glucose_homeostasis1.53227491
44MP0003959_abnormal_lean_body1.52981849
45MP0002837_dystrophic_cardiac_calcinosis1.52913985
46MP0001986_abnormal_taste_sensitivity1.51740615
47MP0005253_abnormal_eye_physiology1.50750035
48MP0003122_maternal_imprinting1.47908138
49MP0003890_abnormal_embryonic-extraembry1.45328976
50MP0008961_abnormal_basal_metabolism1.45053990
51MP0003868_abnormal_feces_composition1.43720392
52MP0002138_abnormal_hepatobiliary_system1.42408401
53MP0010030_abnormal_orbit_morphology1.41232492
54MP0001765_abnormal_ion_homeostasis1.41168875
55MP0003718_maternal_effect1.39838832
56MP0002277_abnormal_respiratory_mucosa1.39762850
57MP0001756_abnormal_urination1.37974853
58MP0002102_abnormal_ear_morphology1.36838039
59MP0005085_abnormal_gallbladder_physiolo1.35433730
60MP0009745_abnormal_behavioral_response1.33931949
61MP0002928_abnormal_bile_duct1.29117670
62MP0001664_abnormal_digestion1.25982993
63MP0001764_abnormal_homeostasis1.25475284
64MP0004133_heterotaxia1.23441305
65MP0003119_abnormal_digestive_system1.23223451
66MP0001919_abnormal_reproductive_system1.20227491
67MP0003942_abnormal_urinary_system1.18478851
68MP0002272_abnormal_nervous_system1.18162586
69MP0005332_abnormal_amino_acid1.17242316
70MP0004019_abnormal_vitamin_homeostasis1.15847609
71MP0010329_abnormal_lipoprotein_level1.13962500
72MP0005389_reproductive_system_phenotype1.12018578
73MP0001984_abnormal_olfaction1.11698749
74MP0003136_yellow_coat_color1.09063972
75MP0000566_synostosis1.08630935
76MP0002098_abnormal_vibrissa_morphology1.08381821
77MP0001501_abnormal_sleep_pattern1.07269703
78MP0002557_abnormal_social/conspecific_i1.07057291
79MP0000534_abnormal_ureter_morphology1.06695660
80MP0000462_abnormal_digestive_system1.06588470
81MP0005636_abnormal_mineral_homeostasis1.05848449
82MP0003953_abnormal_hormone_level1.04553424
83MP0006276_abnormal_autonomic_nervous1.03739809
84MP0003806_abnormal_nucleotide_metabolis1.03076472
85MP0002876_abnormal_thyroid_physiology1.01160028
86MP0002896_abnormal_bone_mineralization1.00937709
87MP0006035_abnormal_mitochondrial_morpho1.00050241
88MP0000383_abnormal_hair_follicle0.98225812
89MP0005645_abnormal_hypothalamus_physiol0.96729454
90MP0001849_ear_inflammation0.93321095
91MP0002572_abnormal_emotion/affect_behav0.92819734
92MP0005410_abnormal_fertilization0.92772575
93MP0001881_abnormal_mammary_gland0.92380159
94MP0000631_abnormal_neuroendocrine_gland0.92042210
95MP0004147_increased_porphyrin_level0.90851250
96MP0001529_abnormal_vocalization0.90560854
97MP0000372_irregular_coat_pigmentation0.90184389
98MP0005386_behavior/neurological_phenoty0.89966413
99MP0004924_abnormal_behavior0.89966413
100MP0008995_early_reproductive_senescence0.89351648
101MP0005647_abnormal_sex_gland0.88044025
102MP0004233_abnormal_muscle_weight0.87807086
103MP0001485_abnormal_pinna_reflex0.86772125
104MP0006036_abnormal_mitochondrial_physio0.85933766
105MP0000516_abnormal_urinary_system0.85578422
106MP0005367_renal/urinary_system_phenotyp0.85578422
107MP0005646_abnormal_pituitary_gland0.85396433
108MP0002229_neurodegeneration0.85306607
109MP0001905_abnormal_dopamine_level0.85147292
110MP0000647_abnormal_sebaceous_gland0.85098685
111MP0002090_abnormal_vision0.84296438
112MP0000470_abnormal_stomach_morphology0.83051247
113MP0003693_abnormal_embryo_hatching0.82839883
114MP0005670_abnormal_white_adipose0.81460156
115MP0002735_abnormal_chemical_nociception0.80691641
116MP0002064_seizures0.80472943
117MP0003121_genomic_imprinting0.80319158
118MP0001502_abnormal_circadian_rhythm0.80082541
119MP0003137_abnormal_impulse_conducting0.79998034
120MP0004742_abnormal_vestibular_system0.79965717
121MP0003186_abnormal_redox_activity0.79771520
122MP0009672_abnormal_birth_weight0.79431263
123MP0005375_adipose_tissue_phenotype0.78266001
124MP0003698_abnormal_male_reproductive0.77956585
125MP0009703_decreased_birth_body0.77275408
126MP0004885_abnormal_endolymph0.77102789
127MP0001486_abnormal_startle_reflex0.76985794
128MP0008058_abnormal_DNA_repair0.75925831
129MP0000537_abnormal_urethra_morphology0.75206962
130MP0004142_abnormal_muscle_tone0.74700382
131MP0001270_distended_abdomen0.74157121
132MP0001970_abnormal_pain_threshold0.73806813
133MP0003786_premature_aging0.73558579
134MP0002938_white_spotting0.73392050
135MP0010678_abnormal_skin_adnexa0.73309986
136MP0002234_abnormal_pharynx_morphology0.73235890
137MP0000049_abnormal_middle_ear0.71831304
138MP0005377_hearing/vestibular/ear_phenot0.71568077
139MP0003878_abnormal_ear_physiology0.71568077
140MP0005408_hypopigmentation0.69861925
141MP0005448_abnormal_energy_balance0.68399303
142MP0002233_abnormal_nose_morphology0.67173781
143MP0002160_abnormal_reproductive_system0.66898041
144MP0008875_abnormal_xenobiotic_pharmacok0.66084775
145MP0002751_abnormal_autonomic_nervous0.64663913
146MP0002111_abnormal_tail_morphology0.64636718
147MP0000762_abnormal_tongue_morphology0.64627045
148MP0001299_abnormal_eye_distance/0.64030740
149MP0005076_abnormal_cell_differentiation0.63853620
150MP0002118_abnormal_lipid_homeostasis0.63494508
151MP0002638_abnormal_pupillary_reflex0.61571043
152MP0000681_abnormal_thyroid_gland0.60198397
153MP0003252_abnormal_bile_duct0.60060946
154MP0000163_abnormal_cartilage_morphology0.59057195
155MP0003300_gastrointestinal_ulcer0.57649569
156MP0002084_abnormal_developmental_patter0.56715129
157MP0000538_abnormal_urinary_bladder0.56467227

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.39724395
2Hypoglycemic seizures (HP:0002173)5.17231507
3Hypoglycemic coma (HP:0001325)4.63248520
4Symptomatic seizures (HP:0011145)4.61229523
5Gout (HP:0001997)4.55845947
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.23208927
7Ketoacidosis (HP:0001993)4.10944615
8Abnormal pancreas size (HP:0012094)3.86684503
9Abnormality of the pancreatic islet cells (HP:0006476)3.83166061
10Abnormality of endocrine pancreas physiology (HP:0012093)3.83166061
11Hyperglycemia (HP:0003074)3.52150838
12Late onset (HP:0003584)3.48654116
13Congenital stationary night blindness (HP:0007642)3.27798580
14Abnormality of calcium-phosphate metabolism (HP:0100530)3.25182014
15Pancreatic cysts (HP:0001737)3.22121676
16Pancreatic fibrosis (HP:0100732)3.19833414
17Pancreatic islet-cell hyperplasia (HP:0004510)3.17981277
18Abnormality of the intrinsic pathway (HP:0010989)3.06628973
19Nephronophthisis (HP:0000090)2.97208433
20Exocrine pancreatic insufficiency (HP:0001738)2.95699790
21Degeneration of anterior horn cells (HP:0002398)2.91239769
22Abnormality of the anterior horn cell (HP:0006802)2.91239769
23Molar tooth sign on MRI (HP:0002419)2.90914660
24Abnormality of midbrain morphology (HP:0002418)2.90914660
25Lip pit (HP:0100267)2.85807467
26Hypothermia (HP:0002045)2.85053628
27True hermaphroditism (HP:0010459)2.84330691
28Generalized aminoaciduria (HP:0002909)2.67176594
29Type II lissencephaly (HP:0007260)2.66657067
30Pendular nystagmus (HP:0012043)2.65192402
31Ketosis (HP:0001946)2.63515158
32Large for gestational age (HP:0001520)2.63429030
33Osteomalacia (HP:0002749)2.63127203
34Acute encephalopathy (HP:0006846)2.62749088
35Methylmalonic acidemia (HP:0002912)2.61305610
36Bifid tongue (HP:0010297)2.60394940
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.59757157
38Acute necrotizing encephalopathy (HP:0006965)2.59743162
39Type I transferrin isoform profile (HP:0003642)2.57869538
40Abnormality of glycine metabolism (HP:0010895)2.57776504
41Abnormality of serine family amino acid metabolism (HP:0010894)2.57776504
42Mitochondrial inheritance (HP:0001427)2.56977550
43Lipid accumulation in hepatocytes (HP:0006561)2.55789005
44Increased CSF lactate (HP:0002490)2.55406323
45Mucopolysacchariduria (HP:0008155)2.53440462
46Urinary glycosaminoglycan excretion (HP:0003541)2.53440462
47Hyperactive renin-angiotensin system (HP:0000841)2.52740166
48Hyperglycinemia (HP:0002154)2.52529382
49Dysautonomia (HP:0002459)2.50758885
50Abnormal protein glycosylation (HP:0012346)2.48738211
51Abnormal glycosylation (HP:0012345)2.48738211
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48738211
53Abnormal protein N-linked glycosylation (HP:0012347)2.48738211
54Concave nail (HP:0001598)2.45792454
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45693559
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45693559
57Abnormality of polysaccharide metabolism (HP:0011012)2.45693559
58Increased hepatocellular lipid droplets (HP:0006565)2.44053044
59Insulin-resistant diabetes mellitus (HP:0000831)2.43189017
60Abnormality of the renal medulla (HP:0100957)2.42289324
61Decreased circulating renin level (HP:0003351)2.42252485
62Intestinal atresia (HP:0011100)2.41840143
63Unilateral renal agenesis (HP:0000122)2.41564802
64Progressive macrocephaly (HP:0004481)2.40771788
65Proximal tubulopathy (HP:0000114)2.37631299
66Hypoplastic labia majora (HP:0000059)2.32866912
67Hepatoblastoma (HP:0002884)2.31874579
68Polydipsia (HP:0001959)2.31221032
69Abnormal drinking behavior (HP:0030082)2.31221032
70Limb hypertonia (HP:0002509)2.30657776
71Hypokalemia (HP:0002900)2.29861063
72Abnormality of chloride homeostasis (HP:0011422)2.28832061
73Attenuation of retinal blood vessels (HP:0007843)2.28128529
74Hypoplasia of the uterus (HP:0000013)2.27452894
75Renal cortical cysts (HP:0000803)2.26661852
76Hyperglycinuria (HP:0003108)2.25593306
77Hepatic necrosis (HP:0002605)2.25427461
78Hypotension (HP:0002615)2.22829614
79Gaze-evoked nystagmus (HP:0000640)2.21981440
80Renal salt wasting (HP:0000127)2.21800944
81Tubulointerstitial nephritis (HP:0001970)2.21377435
82Abnormality of purine metabolism (HP:0004352)2.17942937
83Abnormal mitochondria in muscle tissue (HP:0008316)2.17804178
84Tubular atrophy (HP:0000092)2.17120936
85Abnormal biliary tract morphology (HP:0012440)2.16668352
86Severe muscular hypotonia (HP:0006829)2.16505425
87Hyperuricemia (HP:0002149)2.16358780
88Increased purine levels (HP:0004368)2.16358780
89Abnormality of renal excretion (HP:0011036)2.15039672
90Dysostosis multiplex (HP:0000943)2.14969057
91Increased circulating renin level (HP:0000848)2.13708779
92Testicular atrophy (HP:0000029)2.13194894
93Progressive inability to walk (HP:0002505)2.11985995
94Abnormality of renin-angiotensin system (HP:0000847)2.11550966
95Medial flaring of the eyebrow (HP:0010747)2.11172774
96Hyperkalemia (HP:0002153)2.10915539
97Hepatocellular necrosis (HP:0001404)2.09918086
98Aplasia/hypoplasia of the uterus (HP:0008684)2.08962048
99Abnormality of potassium homeostasis (HP:0011042)2.08878222
100Methylmalonic aciduria (HP:0012120)2.08238160
101Maternal diabetes (HP:0009800)2.07974012
102Hyperparathyroidism (HP:0000843)2.07885417
103Papillary thyroid carcinoma (HP:0002895)2.07391169
104Abnormality of the labia minora (HP:0012880)2.05620917
105Insulin resistance (HP:0000855)2.05537626
106Abnormality of the labia majora (HP:0012881)2.03785370
107Abnormality of the pons (HP:0007361)2.03290460
108Missing ribs (HP:0000921)2.03080299
109Turricephaly (HP:0000262)2.02291498
110Neoplasm of the adrenal cortex (HP:0100641)2.01393481
111Amelogenesis imperfecta (HP:0000705)2.01117969
112Abdominal distention (HP:0003270)2.00905825
113Hypoplasia of the pons (HP:0012110)2.00896050
114Enlarged kidneys (HP:0000105)2.00893038
115Lethargy (HP:0001254)2.00542881
116Birth length less than 3rd percentile (HP:0003561)1.99342819
117Abnormality of the renal cortex (HP:0011035)1.97726091
118Abolished electroretinogram (ERG) (HP:0000550)1.97625065
119Hypoplasia of the fovea (HP:0007750)1.97622145
120Aplasia/Hypoplasia of the fovea (HP:0008060)1.97622145
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97472664
122Abnormality of alanine metabolism (HP:0010916)1.97472664
123Hyperalaninemia (HP:0003348)1.97472664
124Abnormality of vitamin B metabolism (HP:0004340)1.97293711
125Abnormality of magnesium homeostasis (HP:0004921)1.97070599
126Furrowed tongue (HP:0000221)1.97050110
127Facial cleft (HP:0002006)1.96578980
128Agitation (HP:0000713)1.96074087
129Cystic liver disease (HP:0006706)1.95304849
130Male pseudohermaphroditism (HP:0000037)1.94301098
131Inability to walk (HP:0002540)1.94229746
132Hypomagnesemia (HP:0002917)1.92960924
133Abnormal rod and cone electroretinograms (HP:0008323)1.91366616
134Cortical visual impairment (HP:0100704)1.89154691
135Flat capital femoral epiphysis (HP:0003370)1.88400943
136Type I diabetes mellitus (HP:0100651)1.87365532
137Enlarged epiphyses (HP:0010580)1.87139776
138Fat malabsorption (HP:0002630)1.86923060
139Reduced antithrombin III activity (HP:0001976)1.86743871
140Chronic hepatic failure (HP:0100626)1.86409723
141Glycosuria (HP:0003076)1.85504929
142Abnormality of urine glucose concentration (HP:0011016)1.85504929
143Sclerocornea (HP:0000647)1.84941329
144Abnormality of serum amino acid levels (HP:0003112)1.84865087
145Prolonged partial thromboplastin time (HP:0003645)1.83716799
146Renal Fanconi syndrome (HP:0001994)1.83714356
147Absent eyelashes (HP:0000561)1.81361310
148Conjugated hyperbilirubinemia (HP:0002908)1.80190307
149Tachypnea (HP:0002789)1.79780146
150Congenital, generalized hypertrichosis (HP:0004540)1.77772218
151Increased serum lactate (HP:0002151)1.77351136
152Disproportionate short-trunk short stature (HP:0003521)1.77145575
153Tongue fasciculations (HP:0001308)1.76288103
154Polyuria (HP:0000103)1.75895566
155Steatorrhea (HP:0002570)1.75026995
156Chronic bronchitis (HP:0004469)1.74935336
157Optic disc pallor (HP:0000543)1.74860304
158Shawl scrotum (HP:0000049)1.74524800
159Lactic acidosis (HP:0003128)1.74253749
160Patellar aplasia (HP:0006443)1.73821590
161Vacuolated lymphocytes (HP:0001922)1.73277753
162Aplasia/Hypoplasia of the spleen (HP:0010451)1.72501652
163Absent eyebrow (HP:0002223)1.72171747
164Curly hair (HP:0002212)1.72113934
165Hyperventilation (HP:0002883)1.71793645
166Abnormality of alkaline phosphatase activity (HP:0004379)1.71521845
167Scrotal hypoplasia (HP:0000046)1.71281778
168Cerebral edema (HP:0002181)1.70984857
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.69395562
170Abnormal foot bone ossification (HP:0010675)1.68958567
171Abnormal urine output (HP:0012590)1.68908507
172Ectopic anus (HP:0004397)1.68606058
173Hypobetalipoproteinemia (HP:0003563)1.68309789
174Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68024238
175Absent thumb (HP:0009777)1.67977827
176Abnormality of homocysteine metabolism (HP:0010919)1.67344266
177Homocystinuria (HP:0002156)1.67344266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.30187672
2INSRR4.38105552
3BCKDK4.08504391
4ERN13.96349992
5WNK43.55936131
6BMPR1B2.96701133
7AKT32.96620624
8PASK2.95621861
9ACVR1B2.82832705
10GRK12.81686840
11FRK2.66505202
12ADRBK22.55159394
13WNK32.51913941
14MAP4K22.48544807
15MAP2K22.18063770
16MST42.15368845
17EPHA22.15304039
18SIK12.11007706
19HIPK22.06372012
20IRAK41.99115461
21NUAK11.92679742
22MAP3K21.92073395
23FGFR21.88397414
24TAF11.84594697
25TRIB31.84464563
26VRK21.75374071
27OXSR11.72894612
28IRAK31.70438038
29LATS11.67651229
30FLT31.57713308
31TNIK1.56057189
32PIK3CG1.55563133
33EPHA31.53762097
34EIF2AK31.51977945
35BRSK21.50759673
36MAP2K61.48748569
37TRIM281.45624925
38TLK11.45319427
39CAMKK21.44963056
40ZAK1.43968593
41PTK21.40837929
42BRD41.38595574
43PTK61.33762412
44PHKG11.32942574
45PHKG21.32942574
46MUSK1.32092279
47TNK21.30999488
48CASK1.30434217
49CDK121.28159701
50DAPK21.27951047
51WNK11.26424852
52STK38L1.25289913
53MKNK21.23309054
54PDGFRA1.18606522
55PRKCI1.15289516
56TAOK31.11184640
57FER1.08877421
58RPS6KB21.08366421
59MAPKAPK31.08005361
60MAPK131.03722351
61NEK11.03698204
62SCYL21.02010271
63TSSK61.01192723
64NTRK30.99940871
65PRKCG0.99593820
66DYRK20.98602958
67PRKCE0.97088787
68IRAK10.94480734
69CDC42BPA0.94266849
70CSNK1G20.91441162
71MET0.89804099
72TAOK20.89104777
73CSNK1G30.89017617
74PLK30.87992669
75CSNK1G10.86869580
76MAP3K30.86568364
77PRKD30.85731288
78MTOR0.85151214
79DYRK1B0.80549063
80IRAK20.80441262
81STK160.80403949
82UHMK10.79413389
83EIF2AK10.75758298
84NTRK10.75469172
85NEK60.75169834
86STK30.67631671
87VRK10.62750879
88PLK10.62472649
89PAK30.61352702
90BRAF0.61350454
91CAMK1D0.60203561
92PRKD20.59580402
93PNCK0.59561334
94RPS6KA20.59339017
95PKN20.56534888
96CAMK1G0.55985167
97STK380.55817734
98MAP3K40.55774048
99GSK3A0.55432506
100MAP3K120.55336553
101PLK20.54937695
102BUB10.54779502
103CHUK0.53294836
104ADRBK10.53057715
105MAP2K10.53056673
106FGFR10.51419544
107MAPKAPK50.51257148
108TTK0.51253231
109CSNK1A1L0.49671857
110PRKAA20.47252010
111PINK10.45993091
112PAK20.45948201
113RPS6KC10.44886280
114RPS6KL10.44886280
115PDGFRB0.44830071
116STK390.44314371
117PRKCZ0.44123538
118MAP2K70.44109720
119TESK10.44027038
120PIK3CA0.42063948
121ERBB30.41568780
122DYRK30.40611368
123CSNK1D0.40044741
124CAMK2D0.39828809
125BCR0.39751057
126IKBKB0.36885039
127RPS6KA50.35921463
128PRKACA0.35398120
129PRPF4B0.35008724
130ATR0.34628489
131CAMK10.34475383
132CAMKK10.33762788
133ERBB20.32998115
134RPS6KB10.32231702
135CAMK2A0.32203325
136CSNK1A10.31870599
137BRSK10.31270062
138PRKCA0.30503701
139RPS6KA60.30345209
140TAOK10.30274050
141PRKCH0.30214455
142STK110.30066754
143PRKAA10.29295337
144MAPK140.29137864
145PRKG20.29096505
146RPS6KA10.28190222
147PAK40.27989915
148ATM0.27563516
149PTK2B0.27529201
150GRK60.26877872
151NLK0.26703675
152MAP3K10.25722980
153PDK20.24596089
154AURKA0.23929483
155NME20.23483148
156MAPKAPK20.23387378
157AKT10.21796874
158CHEK20.21551506
159NME10.21352613
160RPS6KA40.20291733
161MAPK30.20100737
162DYRK1A0.19270868
163ZAP700.19032435
164CSNK1E0.18592238
165CSNK2A20.17977049
166DDR20.17444332

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.55710268
2Protein export_Homo sapiens_hsa030605.65929969
3Sulfur metabolism_Homo sapiens_hsa009203.62629964
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.26288000
5Pancreatic secretion_Homo sapiens_hsa049723.23501828
6Protein digestion and absorption_Homo sapiens_hsa049742.50487098
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47070238
8Oxidative phosphorylation_Homo sapiens_hsa001902.32145601
9Fat digestion and absorption_Homo sapiens_hsa049752.22689731
10Folate biosynthesis_Homo sapiens_hsa007902.11125991
11Insulin secretion_Homo sapiens_hsa049112.05104204
12N-Glycan biosynthesis_Homo sapiens_hsa005101.94147566
13Selenocompound metabolism_Homo sapiens_hsa004501.89528965
14RNA polymerase_Homo sapiens_hsa030201.80795888
15Galactose metabolism_Homo sapiens_hsa000521.79210178
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77820789
17Vibrio cholerae infection_Homo sapiens_hsa051101.76670054
18Phototransduction_Homo sapiens_hsa047441.76201600
19Proteasome_Homo sapiens_hsa030501.74624702
20Homologous recombination_Homo sapiens_hsa034401.66290732
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.63942092
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59911340
23Parkinsons disease_Homo sapiens_hsa050121.58508307
24Nitrogen metabolism_Homo sapiens_hsa009101.58201927
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50658405
26Basal transcription factors_Homo sapiens_hsa030221.49322676
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43599807
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37652300
29Steroid biosynthesis_Homo sapiens_hsa001001.37014678
30Vitamin B6 metabolism_Homo sapiens_hsa007501.34251743
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30317937
32Other glycan degradation_Homo sapiens_hsa005111.27018451
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26887469
34Fanconi anemia pathway_Homo sapiens_hsa034601.25992595
35Ether lipid metabolism_Homo sapiens_hsa005651.22896944
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22591738
37Circadian rhythm_Homo sapiens_hsa047101.22283128
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22089656
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16038992
40Retinol metabolism_Homo sapiens_hsa008301.14184639
41Huntingtons disease_Homo sapiens_hsa050161.12393079
42Fatty acid elongation_Homo sapiens_hsa000621.12022589
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.09108129
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.07247854
45Alzheimers disease_Homo sapiens_hsa050101.04191600
46Starch and sucrose metabolism_Homo sapiens_hsa005001.02661150
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02660797
48Tryptophan metabolism_Homo sapiens_hsa003801.02117502
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01579190
50RNA degradation_Homo sapiens_hsa030180.98565618
51Fatty acid metabolism_Homo sapiens_hsa012120.97966602
52Nicotine addiction_Homo sapiens_hsa050330.97866126
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95598222
54Glutathione metabolism_Homo sapiens_hsa004800.95409570
55Type II diabetes mellitus_Homo sapiens_hsa049300.94711584
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94666035
57Arginine and proline metabolism_Homo sapiens_hsa003300.94117472
58Propanoate metabolism_Homo sapiens_hsa006400.92314228
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91993733
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90508685
61Sulfur relay system_Homo sapiens_hsa041220.85359796
62Cardiac muscle contraction_Homo sapiens_hsa042600.84686048
63Glycerolipid metabolism_Homo sapiens_hsa005610.84429577
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.83805603
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83320733
66Lysine degradation_Homo sapiens_hsa003100.82031680
67Fatty acid biosynthesis_Homo sapiens_hsa000610.81252940
68Renin-angiotensin system_Homo sapiens_hsa046140.78869258
69Non-homologous end-joining_Homo sapiens_hsa034500.78379105
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78358740
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77065648
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76937040
73Fructose and mannose metabolism_Homo sapiens_hsa000510.76466730
74Taste transduction_Homo sapiens_hsa047420.76412592
75Linoleic acid metabolism_Homo sapiens_hsa005910.73912457
76Pyrimidine metabolism_Homo sapiens_hsa002400.73685044
77Purine metabolism_Homo sapiens_hsa002300.73348890
78Sphingolipid metabolism_Homo sapiens_hsa006000.72497045
79Pyruvate metabolism_Homo sapiens_hsa006200.71803679
80Glucagon signaling pathway_Homo sapiens_hsa049220.71689831
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70305123
82Lysosome_Homo sapiens_hsa041420.69979342
83Thyroid hormone synthesis_Homo sapiens_hsa049180.69743591
84Mineral absorption_Homo sapiens_hsa049780.68558051
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67518455
86Thyroid cancer_Homo sapiens_hsa052160.65937762
87One carbon pool by folate_Homo sapiens_hsa006700.65198487
88Ovarian steroidogenesis_Homo sapiens_hsa049130.64419538
89Insulin resistance_Homo sapiens_hsa049310.63871573
90Arginine biosynthesis_Homo sapiens_hsa002200.63483962
91Collecting duct acid secretion_Homo sapiens_hsa049660.62480101
92Butanoate metabolism_Homo sapiens_hsa006500.62237576
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61708638
94Tyrosine metabolism_Homo sapiens_hsa003500.61511130
95Prolactin signaling pathway_Homo sapiens_hsa049170.60602268
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.59833899
97Chemical carcinogenesis_Homo sapiens_hsa052040.59134072
98Type I diabetes mellitus_Homo sapiens_hsa049400.57491477
99Caffeine metabolism_Homo sapiens_hsa002320.57251990
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.57182841
101Fatty acid degradation_Homo sapiens_hsa000710.56916397
102Serotonergic synapse_Homo sapiens_hsa047260.56619345
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56564439
104Endometrial cancer_Homo sapiens_hsa052130.56523227
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55640595
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55384849
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54853607
108Phenylalanine metabolism_Homo sapiens_hsa003600.53720400
109Prostate cancer_Homo sapiens_hsa052150.51618703
110Tight junction_Homo sapiens_hsa045300.50598776
111Bladder cancer_Homo sapiens_hsa052190.49541283
112Nucleotide excision repair_Homo sapiens_hsa034200.48555291
113beta-Alanine metabolism_Homo sapiens_hsa004100.47993480
114Peroxisome_Homo sapiens_hsa041460.46054733
115Mismatch repair_Homo sapiens_hsa034300.46001943
116Cocaine addiction_Homo sapiens_hsa050300.45153975
117mRNA surveillance pathway_Homo sapiens_hsa030150.45038261
118Regulation of autophagy_Homo sapiens_hsa041400.44719131
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43154185
120Vitamin digestion and absorption_Homo sapiens_hsa049770.43099571
121RNA transport_Homo sapiens_hsa030130.42987526
122mTOR signaling pathway_Homo sapiens_hsa041500.42122944
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41772812
124Olfactory transduction_Homo sapiens_hsa047400.40771216
125Insulin signaling pathway_Homo sapiens_hsa049100.39618189
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39260903
127Prion diseases_Homo sapiens_hsa050200.39147114
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37978249
129Notch signaling pathway_Homo sapiens_hsa043300.36578445
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.36308777
131Histidine metabolism_Homo sapiens_hsa003400.35668891
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35032133
133Amphetamine addiction_Homo sapiens_hsa050310.32717743
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31869869
135Metabolic pathways_Homo sapiens_hsa011000.31389008
136Arachidonic acid metabolism_Homo sapiens_hsa005900.30576582
137ABC transporters_Homo sapiens_hsa020100.28694977
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28640372
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27301475
140AMPK signaling pathway_Homo sapiens_hsa041520.26494109
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26323648
142Hippo signaling pathway_Homo sapiens_hsa043900.26029912
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20507898
144Biosynthesis of amino acids_Homo sapiens_hsa012300.18535939
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18515046
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17908600

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