SYNGR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.60482640
2locomotory exploration behavior (GO:0035641)6.08150292
3* regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04181964
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.91422899
5synaptic vesicle exocytosis (GO:0016079)5.74239648
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.69741064
7glutamate secretion (GO:0014047)5.66332689
8vocalization behavior (GO:0071625)5.53891891
9regulation of synaptic vesicle exocytosis (GO:2000300)5.41748206
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.30705002
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20408407
12regulation of glutamate receptor signaling pathway (GO:1900449)4.89013317
13neuronal action potential propagation (GO:0019227)4.87345091
14neurotransmitter secretion (GO:0007269)4.86309652
15regulation of synaptic vesicle transport (GO:1902803)4.83771848
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.67974374
17exploration behavior (GO:0035640)4.65343592
18protein localization to synapse (GO:0035418)4.64937635
19layer formation in cerebral cortex (GO:0021819)4.44847240
20gamma-aminobutyric acid transport (GO:0015812)4.39913478
21cellular potassium ion homeostasis (GO:0030007)4.39657062
22proline transport (GO:0015824)4.36600795
23amino acid import (GO:0043090)4.36239650
24* regulation of neuronal synaptic plasticity (GO:0048168)4.34046818
25potassium ion homeostasis (GO:0055075)4.33886638
26regulation of synapse structural plasticity (GO:0051823)4.30495176
27neuron cell-cell adhesion (GO:0007158)4.29598294
28synaptic transmission, glutamatergic (GO:0035249)4.23904039
29sodium ion export (GO:0071436)4.23258501
30regulation of synapse maturation (GO:0090128)4.21167019
31* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17524930
32glutamate receptor signaling pathway (GO:0007215)4.13284562
33positive regulation of dendritic spine development (GO:0060999)4.12060798
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02363360
35long-term memory (GO:0007616)4.00964281
36central nervous system myelination (GO:0022010)4.00784153
37axon ensheathment in central nervous system (GO:0032291)4.00784153
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98269756
39neuron-neuron synaptic transmission (GO:0007270)3.98169455
40neurotransmitter transport (GO:0006836)3.95462922
41dendritic spine morphogenesis (GO:0060997)3.93753651
42neurotransmitter-gated ion channel clustering (GO:0072578)3.91884907
43activation of protein kinase A activity (GO:0034199)3.83583751
44positive regulation of membrane potential (GO:0045838)3.82814295
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77657572
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.77637610
47neuromuscular process controlling posture (GO:0050884)3.77033525
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69165101
49neuromuscular process controlling balance (GO:0050885)3.67363636
50positive regulation of synapse maturation (GO:0090129)3.66890589
51negative regulation of dendrite morphogenesis (GO:0050774)3.65742686
52regulation of neurotransmitter levels (GO:0001505)3.64759301
53synaptic vesicle endocytosis (GO:0048488)3.62889938
54regulation of neurotransmitter secretion (GO:0046928)3.62475765
55cerebellar Purkinje cell differentiation (GO:0021702)3.61409101
56cellular sodium ion homeostasis (GO:0006883)3.59943209
57regulation of postsynaptic membrane potential (GO:0060078)3.59516998
58glycine transport (GO:0015816)3.56561550
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51907205
60dendritic spine organization (GO:0097061)3.51542977
61* regulation of synaptic plasticity (GO:0048167)3.49486918
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48594537
63cell communication by electrical coupling (GO:0010644)3.43855286
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.42766891
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.42699537
66neurotransmitter uptake (GO:0001504)3.42284208
67transmission of nerve impulse (GO:0019226)3.41747891
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41528056
69vesicle docking involved in exocytosis (GO:0006904)3.39528804
70regulation of dendritic spine development (GO:0060998)3.37374281
71regulation of dendritic spine morphogenesis (GO:0061001)3.36240124
72regulation of neurotransmitter transport (GO:0051588)3.34058509
73acidic amino acid transport (GO:0015800)3.31937347
74membrane depolarization during action potential (GO:0086010)3.31700957
75synaptic vesicle transport (GO:0048489)3.31228447
76establishment of synaptic vesicle localization (GO:0097480)3.31228447
77long-term synaptic potentiation (GO:0060291)3.31171251
78regulation of vesicle fusion (GO:0031338)3.30857861
79neuron recognition (GO:0008038)3.30554941
80cerebellar Purkinje cell layer development (GO:0021680)3.28180393
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26705497
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26590918
83positive regulation of neurotransmitter transport (GO:0051590)3.25740667
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.25208646
85cytoskeletal anchoring at plasma membrane (GO:0007016)3.25016565
86cell differentiation in hindbrain (GO:0021533)3.24749277
87neuromuscular synaptic transmission (GO:0007274)3.24624100
88auditory behavior (GO:0031223)3.23812242
89positive regulation of neurotransmitter secretion (GO:0001956)3.23331954
90vesicle transport along microtubule (GO:0047496)3.23003836
91response to auditory stimulus (GO:0010996)3.21803960
92prepulse inhibition (GO:0060134)3.21061831
93membrane depolarization (GO:0051899)3.18811475
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18529718
95establishment of mitochondrion localization (GO:0051654)3.15863780
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14679719
97L-amino acid import (GO:0043092)3.12548384
98membrane hyperpolarization (GO:0060081)3.10605091
99regulation of ARF protein signal transduction (GO:0032012)3.10372684
100dendrite morphogenesis (GO:0048813)3.10242920
101potassium ion import (GO:0010107)3.09575247
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08681797
103regulation of exocytosis (GO:0017157)3.07914876
104vesicle docking (GO:0048278)3.07740888
105cerebellar granule cell differentiation (GO:0021707)3.06776067
106neuromuscular process (GO:0050905)3.05810137
107synaptic transmission (GO:0007268)3.03935358
108intraspecies interaction between organisms (GO:0051703)3.03537648
109social behavior (GO:0035176)3.03537648
110neuronal ion channel clustering (GO:0045161)3.02711486
111postsynaptic membrane organization (GO:0001941)3.02259144
112axonal fasciculation (GO:0007413)3.01737265
113positive regulation of synaptic transmission (GO:0050806)3.00685095
114regulation of voltage-gated calcium channel activity (GO:1901385)3.00365042
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99745197
116* regulation of synaptic transmission (GO:0050804)2.98261192
117learning (GO:0007612)2.97523264
118innervation (GO:0060384)2.96410116
119mating behavior (GO:0007617)2.96083528
120regulation of clathrin-mediated endocytosis (GO:2000369)2.93755211
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.93623892
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93620338
123synapse assembly (GO:0007416)2.93045147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09847407
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17133363
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10879269
4GBX2_23144817_ChIP-Seq_PC3_Human3.08097771
5REST_21632747_ChIP-Seq_MESCs_Mouse3.05006841
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05002452
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.91797047
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80640225
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80640225
10DROSHA_22980978_ChIP-Seq_HELA_Human2.78632908
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68043707
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63674609
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63056529
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.56372422
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55954045
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47033415
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44322991
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.40253346
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.39735539
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37240065
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31754515
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.29958711
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26965337
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23014160
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.19652152
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16595590
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.13086244
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91369772
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.90770509
30AR_21572438_ChIP-Seq_LNCaP_Human1.70736255
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63429623
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57468761
33LXR_22292898_ChIP-Seq_THP-1_Human1.56136674
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55464857
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.53944382
36* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51995001
37SMAD4_21799915_ChIP-Seq_A2780_Human1.51403505
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49052570
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48367051
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42372090
41ZNF274_21170338_ChIP-Seq_K562_Hela1.38224408
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33380783
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.33354286
44KDM2B_26808549_Chip-Seq_K562_Human1.32770775
45TAF15_26573619_Chip-Seq_HEK293_Human1.32734198
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30620101
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30440422
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30249065
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.30228610
50* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29469317
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27782216
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25601037
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24827761
54AR_19668381_ChIP-Seq_PC3_Human1.23534903
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22828270
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21525750
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20772696
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.18521726
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16981855
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15861976
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15409855
62OCT4_19829295_ChIP-Seq_ESCs_Human1.14851917
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13409177
64AR_25329375_ChIP-Seq_VCAP_Human1.13265905
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12632281
66STAT3_23295773_ChIP-Seq_U87_Human1.11615217
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11602248
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10716208
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10649396
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08689848
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08544384
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.06666399
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.06461614
74P300_19829295_ChIP-Seq_ESCs_Human1.03818723
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02498633
76* P68_20966046_ChIP-Seq_HELA_Human1.02260761
77TET1_21490601_ChIP-Seq_MESCs_Mouse1.02042862
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99897790
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99713137
80DPY_21335234_ChIP-Seq_ESCs_Mouse0.98051059
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97775507
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97616250
83YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97003630
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96750076
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.96045940
86CREB1_26743006_Chip-Seq_LNCaP_Human0.95969813
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95274343
88* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95100972
89* TCF4_23295773_ChIP-Seq_U87_Human0.94815455
90* KDM2B_26808549_Chip-Seq_DND41_Human0.94720037
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.94460219
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94266387
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.93934790
94CTCF_27219007_Chip-Seq_Bcells_Human0.93894630
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.93441230
96* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93239054
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92801900
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92516333
99AHR_22903824_ChIP-Seq_MCF-7_Human0.92132461
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90803821
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.90294334
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.89938100
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87016705
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.86149817
105EGR1_19032775_ChIP-ChIP_M12_Human0.85965263
106RXR_22108803_ChIP-Seq_LS180_Human0.84373972
107CBX2_27304074_Chip-Seq_ESCs_Mouse0.83604196
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83082235
109BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82737169
110RUNX2_22187159_ChIP-Seq_PCA_Human0.82383526
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82265376
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.81980847
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81845788
114RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81819799
115KLF4_19829295_ChIP-Seq_ESCs_Human0.81784392
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81561164
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80808151
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80626791
119RNF2_27304074_Chip-Seq_NSC_Mouse0.80552019
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79655898
121* SMAD4_21741376_ChIP-Seq_ESCs_Human0.79351142
122* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79063258
123MYC_19915707_ChIP-ChIP_AK7_Human0.78773169
124IGF1R_20145208_ChIP-Seq_DFB_Human0.78530634
125* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77806166
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.77612646
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76791525
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76780396
129SMC4_20622854_ChIP-Seq_HELA_Human0.76065914
130* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.75340660
131SA1_27219007_Chip-Seq_Bcells_Human0.74056391
132KDM2B_26808549_Chip-Seq_JURKAT_Human0.73750553
133* TP53_23651856_ChIP-Seq_MEFs_Mouse0.73374000
134NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.72995748
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69997638
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68549360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity6.51697630
2MP0003880_abnormal_central_pattern4.61406114
3* MP0003635_abnormal_synaptic_transmissio4.26865385
4MP0004270_analgesia3.79526999
5MP0009745_abnormal_behavioral_response3.46629246
6MP0009046_muscle_twitch3.46159114
7MP0002064_seizures3.34730447
8MP0002063_abnormal_learning/memory/cond3.32544898
9MP0001968_abnormal_touch/_nociception3.14556987
10MP0005423_abnormal_somatic_nervous2.99179070
11MP0002572_abnormal_emotion/affect_behav2.78752913
12MP0002734_abnormal_mechanical_nocicepti2.78567656
13MP0002822_catalepsy2.70367812
14MP0002272_abnormal_nervous_system2.69651643
15MP0001486_abnormal_startle_reflex2.52335554
16MP0002736_abnormal_nociception_after2.38868479
17MP0001501_abnormal_sleep_pattern2.34510912
18MP0002735_abnormal_chemical_nociception2.23791422
19MP0001440_abnormal_grooming_behavior2.20476998
20MP0002733_abnormal_thermal_nociception2.15691116
21MP0008569_lethality_at_weaning2.14374181
22MP0001970_abnormal_pain_threshold2.08581863
23MP0004858_abnormal_nervous_system2.05159053
24MP0003329_amyloid_beta_deposits2.04584942
25MP0002067_abnormal_sensory_capabilities2.02589564
26MP0009780_abnormal_chondrocyte_physiolo1.97605621
27MP0004811_abnormal_neuron_physiology1.83421181
28MP0002909_abnormal_adrenal_gland1.83251604
29MP0002184_abnormal_innervation1.78747116
30MP0004924_abnormal_behavior1.78580375
31MP0005386_behavior/neurological_phenoty1.78580375
32MP0002557_abnormal_social/conspecific_i1.70387404
33MP0003879_abnormal_hair_cell1.65561321
34MP0000955_abnormal_spinal_cord1.57430579
35MP0000778_abnormal_nervous_system1.55007288
36MP0004885_abnormal_endolymph1.54364883
37MP0003123_paternal_imprinting1.53149476
38MP0006276_abnormal_autonomic_nervous1.51440090
39MP0002066_abnormal_motor_capabilities/c1.47356169
40MP0003633_abnormal_nervous_system1.46028398
41MP0005646_abnormal_pituitary_gland1.43467310
42MP0001984_abnormal_olfaction1.42817722
43MP0002882_abnormal_neuron_morphology1.42348648
44MP0004147_increased_porphyrin_level1.40151862
45MP0004142_abnormal_muscle_tone1.30586442
46MP0003787_abnormal_imprinting1.24979880
47MP0003631_nervous_system_phenotype1.23610855
48MP0000751_myopathy1.19393984
49MP0001502_abnormal_circadian_rhythm1.18487705
50MP0001905_abnormal_dopamine_level1.17764832
51MP0005645_abnormal_hypothalamus_physiol1.17716978
52MP0004145_abnormal_muscle_electrophysio1.12866931
53MP0008872_abnormal_physiological_respon1.11111884
54MP0002229_neurodegeneration1.10253434
55MP0003122_maternal_imprinting1.07190134
56MP0002152_abnormal_brain_morphology1.07174434
57MP0001529_abnormal_vocalization1.06426039
58MP0003283_abnormal_digestive_organ1.02908222
59MP0003690_abnormal_glial_cell1.01844051
60MP0005551_abnormal_eye_electrophysiolog0.98649554
61MP0000569_abnormal_digit_pigmentation0.98169959
62MP0000604_amyloidosis0.97339051
63MP0003634_abnormal_glial_cell0.94514041
64MP0003075_altered_response_to0.94435792
65MP0008961_abnormal_basal_metabolism0.94287241
66MP0003632_abnormal_nervous_system0.93625468
67MP0000013_abnormal_adipose_tissue0.93161366
68MP0008874_decreased_physiological_sensi0.92936940
69MP0002069_abnormal_eating/drinking_beha0.91642778
70MP0003172_abnormal_lysosome_physiology0.87531246
71MP0005535_abnormal_body_temperature0.86265280
72MP0002837_dystrophic_cardiac_calcinosis0.85842133
73MP0000920_abnormal_myelination0.85519080
74MP0001986_abnormal_taste_sensitivity0.85443675
75MP0004215_abnormal_myocardial_fiber0.85321414
76MP0002090_abnormal_vision0.84593065
77MP0001177_atelectasis0.83766828
78MP0001346_abnormal_lacrimal_gland0.83374773
79MP0010386_abnormal_urinary_bladder0.82836187
80MP0001348_abnormal_lacrimal_gland0.82654939
81MP0004085_abnormal_heartbeat0.82051831
82MP0004742_abnormal_vestibular_system0.80461413
83MP0005167_abnormal_blood-brain_barrier0.77553755
84MP0004484_altered_response_of0.76937715
85MP0005499_abnormal_olfactory_system0.76592861
86MP0005394_taste/olfaction_phenotype0.76592861
87MP0008877_abnormal_DNA_methylation0.75307701
88MP0001963_abnormal_hearing_physiology0.74165645
89MP0004233_abnormal_muscle_weight0.71938744
90MP0004510_myositis0.71235844
91MP0003137_abnormal_impulse_conducting0.70575981
92MP0002638_abnormal_pupillary_reflex0.70439724
93MP0002752_abnormal_somatic_nervous0.70302258
94MP0000747_muscle_weakness0.64590182
95MP0003646_muscle_fatigue0.63970897
96MP0004043_abnormal_pH_regulation0.63274301
97MP0005623_abnormal_meninges_morphology0.63185735
98MP0003121_genomic_imprinting0.62635822
99MP0001188_hyperpigmentation0.62184991
100MP0000579_abnormal_nail_morphology0.60309791
101MP0010234_abnormal_vibrissa_follicle0.58120079
102MP0001485_abnormal_pinna_reflex0.56142392
103MP0010768_mortality/aging0.55886978
104MP0000631_abnormal_neuroendocrine_gland0.54156129
105MP0001664_abnormal_digestion0.54145789
106MP0010769_abnormal_survival0.53962227
107MP0002082_postnatal_lethality0.53632978
108MP0010770_preweaning_lethality0.53632978
109MP0004130_abnormal_muscle_cell0.53618054
110MP0003956_abnormal_body_size0.51497692
111MP0001943_abnormal_respiration0.51487608
112MP0000681_abnormal_thyroid_gland0.50111781
113MP0005171_absent_coat_pigmentation0.49600126
114MP0002249_abnormal_larynx_morphology0.48453074
115MP0003861_abnormal_nervous_system0.47334459
116MP0002873_normal_phenotype0.46502717
117MP0000639_abnormal_adrenal_gland0.44832224
118MP0002169_no_abnormal_phenotype0.44669120
119MP0000026_abnormal_inner_ear0.43167146

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.45564569
2Myokymia (HP:0002411)7.13032209
3Visual hallucinations (HP:0002367)5.89571897
4Focal seizures (HP:0007359)5.84384142
5Atonic seizures (HP:0010819)4.69623082
6Epileptic encephalopathy (HP:0200134)4.64569621
7Progressive cerebellar ataxia (HP:0002073)4.55480204
8Action tremor (HP:0002345)4.46692845
9Febrile seizures (HP:0002373)4.42877980
10Absence seizures (HP:0002121)4.23710445
11Cerebral hypomyelination (HP:0006808)4.13605015
12Generalized tonic-clonic seizures (HP:0002069)3.96905706
13Supranuclear gaze palsy (HP:0000605)3.96748847
14Dialeptic seizures (HP:0011146)3.85269585
15Ankle clonus (HP:0011448)3.71927554
16Obstructive sleep apnea (HP:0002870)3.51591085
17Depression (HP:0000716)3.50524332
18Gaze-evoked nystagmus (HP:0000640)3.48105474
19Poor eye contact (HP:0000817)3.46031354
20Mutism (HP:0002300)3.43956671
21Dysdiadochokinesis (HP:0002075)3.36189854
22Broad-based gait (HP:0002136)3.35881328
23Postural instability (HP:0002172)3.27136382
24Impaired vibration sensation in the lower limbs (HP:0002166)3.26395745
25Urinary bladder sphincter dysfunction (HP:0002839)3.20955867
26Abnormal social behavior (HP:0012433)3.20085256
27Impaired social interactions (HP:0000735)3.20085256
28Dysmetria (HP:0001310)3.15745106
29Papilledema (HP:0001085)3.14016687
30Abnormality of the lower motor neuron (HP:0002366)3.10919885
31Truncal ataxia (HP:0002078)3.08479377
32Anxiety (HP:0000739)3.08087311
33Abnormal eating behavior (HP:0100738)3.05528010
34Akinesia (HP:0002304)2.99766252
35Ventricular fibrillation (HP:0001663)2.99734208
36Impaired smooth pursuit (HP:0007772)2.90612844
37Genetic anticipation (HP:0003743)2.83339425
38Hemiplegia (HP:0002301)2.78763830
39Abnormality of binocular vision (HP:0011514)2.75903715
40Diplopia (HP:0000651)2.75903715
41Intention tremor (HP:0002080)2.75702159
42Urinary urgency (HP:0000012)2.75221539
43Amblyopia (HP:0000646)2.74961064
44Progressive inability to walk (HP:0002505)2.70197120
45Bradykinesia (HP:0002067)2.68503640
46Hemiparesis (HP:0001269)2.65354883
47Spastic gait (HP:0002064)2.63301516
48Dysmetric saccades (HP:0000641)2.62189423
49Sleep apnea (HP:0010535)2.62011460
50Scanning speech (HP:0002168)2.61803801
51Abnormality of ocular smooth pursuit (HP:0000617)2.59521657
52Torticollis (HP:0000473)2.58430194
53Pheochromocytoma (HP:0002666)2.56401609
54Hyperventilation (HP:0002883)2.53164818
55Neurofibrillary tangles (HP:0002185)2.52892914
56Cerebral inclusion bodies (HP:0100314)2.51984232
57CNS hypomyelination (HP:0003429)2.51747220
58Status epilepticus (HP:0002133)2.50490765
59Diminished motivation (HP:0000745)2.48788148
60Focal dystonia (HP:0004373)2.44018691
61Bundle branch block (HP:0011710)2.43872377
62Annular pancreas (HP:0001734)2.42243583
63Drooling (HP:0002307)2.39266631
64Excessive salivation (HP:0003781)2.39266631
65Choreoathetosis (HP:0001266)2.37766357
66Stereotypic behavior (HP:0000733)2.34591068
67Fetal akinesia sequence (HP:0001989)2.32947390
68Limb dystonia (HP:0002451)2.28820977
69Spastic tetraparesis (HP:0001285)2.27705798
70Abnormality of the corticospinal tract (HP:0002492)2.27075646
71Termporal pattern (HP:0011008)2.26967841
72Insidious onset (HP:0003587)2.26967841
73Epileptiform EEG discharges (HP:0011182)2.25986707
74Impaired vibratory sensation (HP:0002495)2.22653697
75EEG with generalized epileptiform discharges (HP:0011198)2.22090700
76Lower limb muscle weakness (HP:0007340)2.20865058
77Neuronal loss in central nervous system (HP:0002529)2.19243336
78Neuroendocrine neoplasm (HP:0100634)2.18104209
79Megalencephaly (HP:0001355)2.16354970
80Craniofacial dystonia (HP:0012179)2.15241382
81Insomnia (HP:0100785)2.14435403
82Hypsarrhythmia (HP:0002521)2.13717297
83Agitation (HP:0000713)2.13092218
84Generalized myoclonic seizures (HP:0002123)2.12559037
85Morphological abnormality of the pyramidal tract (HP:0002062)2.11401545
86Polyphagia (HP:0002591)2.07291917
87Amyotrophic lateral sclerosis (HP:0007354)2.06762686
88Unsteady gait (HP:0002317)2.06495476
89Rapidly progressive (HP:0003678)2.06420733
90Clonus (HP:0002169)2.04737831
91Rigidity (HP:0002063)2.04477092
92Pointed chin (HP:0000307)2.03856492
93Delusions (HP:0000746)2.03351236
94Absent speech (HP:0001344)2.02308282
95Inability to walk (HP:0002540)2.00337811
96Gait ataxia (HP:0002066)2.00258505
97Spinal canal stenosis (HP:0003416)1.99789194
98Abnormality of saccadic eye movements (HP:0000570)1.99611395
99Resting tremor (HP:0002322)1.98320131
100Tetraplegia (HP:0002445)1.97182008
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.95442983
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95442983
103Abnormal EKG (HP:0003115)1.92776480
104Incomplete penetrance (HP:0003829)1.91980998
105Apathy (HP:0000741)1.89854688
106Psychosis (HP:0000709)1.89582771
107Iris hypopigmentation (HP:0007730)1.88346052
108Postural tremor (HP:0002174)1.87720111
109Lower limb amyotrophy (HP:0007210)1.87698004
110Peripheral hypomyelination (HP:0007182)1.87384494
111Neoplasm of the peripheral nervous system (HP:0100007)1.87365892
112Failure to thrive in infancy (HP:0001531)1.86990428
113Lower limb asymmetry (HP:0100559)1.84569886
114Ocular albinism (HP:0001107)1.83121101
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82060551
116Blue irides (HP:0000635)1.79792425
117Memory impairment (HP:0002354)1.78968297
118Aplasia involving bones of the extremities (HP:0009825)1.78745545
119Aplasia involving bones of the upper limbs (HP:0009823)1.78745545
120Aplasia of the phalanges of the hand (HP:0009802)1.78745545
121Dementia (HP:0000726)1.75036752
122Heart block (HP:0012722)1.73331073
123Hand muscle atrophy (HP:0009130)1.72550473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.33755589
2NTRK34.22282188
3EPHA43.82082974
4MAP3K43.04422646
5MARK12.92607092
6MINK12.77574441
7DAPK22.74851228
8PAK62.48796161
9MAP2K72.40368525
10KSR22.33779948
11CAMKK12.16054062
12PRKD32.15765966
13NTRK12.13825955
14NTRK22.04450524
15MAP2K41.99013925
16MAP3K121.95025237
17RIPK41.89437269
18GRK51.67300378
19STK381.60910482
20DAPK11.58489965
21CDK51.56119779
22ARAF1.51123737
23CAMKK21.46197067
24CDK191.44990345
25PLK21.39711743
26PNCK1.38274159
27KSR11.37075691
28SIK21.30606579
29MAP3K21.29351006
30PRKCG1.24123622
31TYRO31.22422143
32PHKG11.16334965
33PHKG21.16334965
34UHMK11.16052449
35PINK11.13022512
36PRPF4B1.11945934
37LATS21.11525713
38TAOK11.10288264
39FES1.07588839
40LMTK21.05775921
41CASK1.05427976
42TNIK1.04253123
43MAPK131.03861346
44MAP3K131.03467804
45ALK1.01391421
46CAMK11.00566802
47MAP3K110.97796413
48STK110.97690704
49MAPK120.96615339
50CDK150.93945223
51RET0.93607006
52PRKCH0.93192404
53CDK180.93155243
54CAMK2A0.89992049
55SGK4940.88952277
56SGK2230.88952277
57CDK140.88821549
58NEK10.83926254
59CDK11A0.81934306
60SCYL20.76670257
61RAF10.73954988
62RIPK10.72906723
63PDK10.72673032
64PKN10.72590815
65SGK30.72283670
66PAK30.71901356
67BRAF0.71629411
68SGK20.71508360
69OXSR10.70041955
70PTK2B0.69729336
71LIMK10.69700137
72TESK10.68158170
73CAMK2B0.67937344
74PDPK10.66533972
75CSNK1G20.66284231
76MAP3K10.65706925
77TNK20.63577902
78SGK10.62020050
79WNK10.60317155
80BRSK10.58566737
81DYRK1A0.58433140
82MARK20.57485503
83CDC42BPA0.53274882
84RPS6KA30.50400732
85CAMK40.50225460
86CAMK2G0.49813137
87BMPR20.48047088
88DAPK30.47598048
89PRKCZ0.47548016
90CAMK2D0.46088614
91MAPK100.45721718
92CAMK1G0.45408556
93FYN0.43263533
94CCNB10.42484927
95PRKCE0.40769548
96MAP2K10.40263329
97MAP3K70.38547384
98FGFR20.38422723
99NEK60.37438634
100FER0.35573196
101MAPKAPK50.34856574
102PRKCA0.34691330
103MAP2K60.33510837
104MAP3K60.32743865
105NME10.32564374
106RPS6KA20.31519611
107PDK30.31285289
108PDK40.31285289
109FGR0.30430043
110ROCK20.29635913
111MAPK80.27411744
112MAPK40.26327999
113PRKG20.24292178
114SRC0.23552969
115ERBB20.23106930
116DYRK20.22780845
117PRKCB0.22377847
118PRKACA0.22153140
119ROCK10.21921467

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.66789150
2Nicotine addiction_Homo sapiens_hsa050333.61122656
3Olfactory transduction_Homo sapiens_hsa047402.77040559
4GABAergic synapse_Homo sapiens_hsa047272.71934300
5Circadian entrainment_Homo sapiens_hsa047132.62645043
6Long-term potentiation_Homo sapiens_hsa047202.61945756
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59855002
8Glutamatergic synapse_Homo sapiens_hsa047242.53741983
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49228853
10Morphine addiction_Homo sapiens_hsa050322.41880157
11Amphetamine addiction_Homo sapiens_hsa050312.34593790
12Salivary secretion_Homo sapiens_hsa049702.19179047
13Dopaminergic synapse_Homo sapiens_hsa047282.09888097
14Insulin secretion_Homo sapiens_hsa049112.03954944
15Gastric acid secretion_Homo sapiens_hsa049711.96280565
16Cholinergic synapse_Homo sapiens_hsa047251.87436993
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83134621
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72466161
19Taste transduction_Homo sapiens_hsa047421.70896588
20Long-term depression_Homo sapiens_hsa047301.68748915
21Collecting duct acid secretion_Homo sapiens_hsa049661.62089807
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60746794
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60028112
24Vitamin B6 metabolism_Homo sapiens_hsa007501.58674975
25Renin secretion_Homo sapiens_hsa049241.54296449
26Calcium signaling pathway_Homo sapiens_hsa040201.52766140
27Cocaine addiction_Homo sapiens_hsa050301.51181150
28Serotonergic synapse_Homo sapiens_hsa047261.49923798
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46112557
30GnRH signaling pathway_Homo sapiens_hsa049121.45787088
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43043943
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33574531
33Gap junction_Homo sapiens_hsa045401.32279629
34Type II diabetes mellitus_Homo sapiens_hsa049301.29562854
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21631778
36cAMP signaling pathway_Homo sapiens_hsa040241.21308372
37Estrogen signaling pathway_Homo sapiens_hsa049151.19406796
38Nitrogen metabolism_Homo sapiens_hsa009101.14226695
39Glioma_Homo sapiens_hsa052141.11725791
40Cardiac muscle contraction_Homo sapiens_hsa042601.10123121
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05131465
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99036261
43Vibrio cholerae infection_Homo sapiens_hsa051100.97892566
44Melanogenesis_Homo sapiens_hsa049160.97824453
45ErbB signaling pathway_Homo sapiens_hsa040120.95764822
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95318075
47Oocyte meiosis_Homo sapiens_hsa041140.94804757
48Phototransduction_Homo sapiens_hsa047440.92114833
49Pancreatic secretion_Homo sapiens_hsa049720.90089762
50Axon guidance_Homo sapiens_hsa043600.87357649
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.86327151
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.86145695
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85273005
54Dorso-ventral axis formation_Homo sapiens_hsa043200.83375306
55Thyroid hormone synthesis_Homo sapiens_hsa049180.80909310
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77803228
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76777335
58Dilated cardiomyopathy_Homo sapiens_hsa054140.73591803
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72507346
60Choline metabolism in cancer_Homo sapiens_hsa052310.66763793
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66021698
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.65835596
63MAPK signaling pathway_Homo sapiens_hsa040100.64813870
64mTOR signaling pathway_Homo sapiens_hsa041500.62817276
65VEGF signaling pathway_Homo sapiens_hsa043700.61678713
66Endocytosis_Homo sapiens_hsa041440.58797435
67Inositol phosphate metabolism_Homo sapiens_hsa005620.57928441
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56537835
69Bile secretion_Homo sapiens_hsa049760.55749344
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55738710
71Glucagon signaling pathway_Homo sapiens_hsa049220.55386040
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.53167287
73Type I diabetes mellitus_Homo sapiens_hsa049400.50379264
74Ras signaling pathway_Homo sapiens_hsa040140.47661612
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47413753
76Rap1 signaling pathway_Homo sapiens_hsa040150.47362957
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47233497
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46862530
79Insulin signaling pathway_Homo sapiens_hsa049100.45941984
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45648653
81Alcoholism_Homo sapiens_hsa050340.44210868
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43347625
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43070756
84Prion diseases_Homo sapiens_hsa050200.42892023
85Arginine and proline metabolism_Homo sapiens_hsa003300.42548607
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41913304
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40884028
88Renal cell carcinoma_Homo sapiens_hsa052110.40587903
89Endometrial cancer_Homo sapiens_hsa052130.40332446
90Circadian rhythm_Homo sapiens_hsa047100.40101932
91Non-small cell lung cancer_Homo sapiens_hsa052230.38727921
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36747482
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35814090
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.35596373
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35432245
96Alzheimers disease_Homo sapiens_hsa050100.34703762
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33533078
98Chemokine signaling pathway_Homo sapiens_hsa040620.29383407
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.29305023
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28773806
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28685602
102Wnt signaling pathway_Homo sapiens_hsa043100.28516513
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28461165
104Ovarian steroidogenesis_Homo sapiens_hsa049130.27238024
105Arginine biosynthesis_Homo sapiens_hsa002200.26513146
106Oxidative phosphorylation_Homo sapiens_hsa001900.23534877
107AMPK signaling pathway_Homo sapiens_hsa041520.23520768
108Parkinsons disease_Homo sapiens_hsa050120.21253857
109HIF-1 signaling pathway_Homo sapiens_hsa040660.18397854
110beta-Alanine metabolism_Homo sapiens_hsa004100.12820324
111Regulation of autophagy_Homo sapiens_hsa041400.12733299
112Fatty acid biosynthesis_Homo sapiens_hsa000610.11548336
113Mineral absorption_Homo sapiens_hsa049780.11315293
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10355629

Most similar genes based on co-expression Upload to Enrichr

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