SYNGR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.98944807
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.30557367
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.30557367
4NIK/NF-kappaB signaling (GO:0038061)4.29255510
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23975468
6positive regulation of antigen processing and presentation (GO:0002579)4.08089798
7regulation of dendritic cell antigen processing and presentation (GO:0002604)3.96590493
8neutrophil activation involved in immune response (GO:0002283)3.83672911
9immunoglobulin mediated immune response (GO:0016064)3.73224856
10regulation of antigen processing and presentation (GO:0002577)3.58788011
11ribosomal small subunit assembly (GO:0000028)3.54985856
12cellular response to zinc ion (GO:0071294)3.48468700
13regulation of interleukin-12 biosynthetic process (GO:0045075)3.41596669
14myeloid dendritic cell differentiation (GO:0043011)3.38574784
15detection of bacterium (GO:0016045)3.36063552
16myeloid dendritic cell activation (GO:0001773)3.34007532
17antigen processing and presentation via MHC class Ib (GO:0002475)3.32462678
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31411792
19positive regulation of Cdc42 GTPase activity (GO:0043089)3.27868438
20response to interferon-beta (GO:0035456)3.27483309
21B cell mediated immunity (GO:0019724)3.25205720
22positive regulation of interferon-alpha production (GO:0032727)3.24550988
23positive regulation of B cell differentiation (GO:0045579)3.21441676
24positive regulation of natural killer cell differentiation (GO:0032825)3.18838409
25regulation of RIG-I signaling pathway (GO:0039535)3.16413654
26GDP-mannose metabolic process (GO:0019673)3.16257894
27dendritic cell differentiation (GO:0097028)3.16117889
28detection of other organism (GO:0098543)3.15039971
29cellular response to interferon-beta (GO:0035458)3.08249206
30regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05864536
31regulation of interferon-alpha production (GO:0032647)3.05225400
32regulation of T-helper 1 cell differentiation (GO:0045625)3.04932194
33positive regulation of gamma-delta T cell activation (GO:0046645)3.04194705
34type I interferon signaling pathway (GO:0060337)3.02107146
35cellular response to type I interferon (GO:0071357)3.02107146
36response to type I interferon (GO:0034340)2.99772728
37neutrophil activation (GO:0042119)2.95445751
38interferon-gamma secretion (GO:0072643)2.90725798
39positive regulation of interleukin-12 production (GO:0032735)2.90672871
40regulation of hypersensitivity (GO:0002883)2.90542012
41positive thymic T cell selection (GO:0045059)2.90084734
42thymic T cell selection (GO:0045061)2.89109899
43cellular response to exogenous dsRNA (GO:0071360)2.89028633
44B cell receptor signaling pathway (GO:0050853)2.87643340
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86257886
46negative regulation of cell killing (GO:0031342)2.85858312
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85858312
48negative regulation of myeloid cell apoptotic process (GO:0033033)2.85354721
49defense response to protozoan (GO:0042832)2.84823589
50regulation of interferon-beta biosynthetic process (GO:0045357)2.84150654
51interferon-gamma-mediated signaling pathway (GO:0060333)2.81981742
52CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81104625
53granulocyte activation (GO:0036230)2.78248352
54respiratory burst (GO:0045730)2.76050242
55response to muramyl dipeptide (GO:0032495)2.75424200
56regulation of gamma-delta T cell activation (GO:0046643)2.75245600
57regulation of B cell differentiation (GO:0045577)2.73386219
58negative regulation of erythrocyte differentiation (GO:0045647)2.70724450
59mature B cell differentiation involved in immune response (GO:0002313)2.68938260
60macrophage activation involved in immune response (GO:0002281)2.68762628
61response to protozoan (GO:0001562)2.68597937
62Golgi transport vesicle coating (GO:0048200)2.67949908
63COPI coating of Golgi vesicle (GO:0048205)2.67949908
64regulation of B cell receptor signaling pathway (GO:0050855)2.67681182
65natural killer cell mediated cytotoxicity (GO:0042267)2.67340497
66natural killer cell mediated immunity (GO:0002228)2.67340497
67response to peptidoglycan (GO:0032494)2.66998333
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66865246
69regulation of superoxide anion generation (GO:0032928)2.66008120
70negative thymic T cell selection (GO:0045060)2.65993780
71germinal center formation (GO:0002467)2.65990292
72negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64578257
73regulation of necroptotic process (GO:0060544)2.62680850
74positive regulation of neutrophil migration (GO:1902624)2.61776439
75positive regulation of neutrophil chemotaxis (GO:0090023)2.61776439
76leukocyte mediated cytotoxicity (GO:0001909)2.60892718
77positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.60765398
78positive regulation of granulocyte chemotaxis (GO:0071624)2.60362122
79regulation of interleukin-12 production (GO:0032655)2.57985188
80T cell costimulation (GO:0031295)2.57016566
81cellular response to interferon-gamma (GO:0071346)2.56856112
82pinocytosis (GO:0006907)2.56698236
83dendritic cell chemotaxis (GO:0002407)2.55859989
84response to host immune response (GO:0052572)2.55313476
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55313476
86negative regulation of interleukin-12 production (GO:0032695)2.54767945
87chaperone mediated protein folding requiring cofactor (GO:0051085)2.53995590
88negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.53771208
89lymphocyte costimulation (GO:0031294)2.53498965
90mannose metabolic process (GO:0006013)2.53050810
91B cell homeostasis (GO:0001782)2.52043587
92modulation by symbiont of host cellular process (GO:0044068)2.51703897
93T-helper 1 type immune response (GO:0042088)2.51545614
94negative regulation of phagocytosis (GO:0050765)2.50712221
95DNA deamination (GO:0045006)2.50323515
96regulation of natural killer cell differentiation (GO:0032823)2.49210429
97viral transcription (GO:0019083)2.48958836
98regulation of mast cell degranulation (GO:0043304)2.48788184
99T cell migration (GO:0072678)2.47510795
100modulation by virus of host process (GO:0019054)2.47126277
101regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.46070462
102cellular response to virus (GO:0098586)2.45517697
103regulation of activation of Janus kinase activity (GO:0010533)2.45288788
104amino sugar catabolic process (GO:0046348)2.44753365
105proline biosynthetic process (GO:0006561)2.44372046
106response to interferon-alpha (GO:0035455)2.43349675
107tumor necrosis factor-mediated signaling pathway (GO:0033209)2.43206963
108response to interferon-gamma (GO:0034341)2.41966737
109negative T cell selection (GO:0043383)2.41694929
110positive regulation of type 2 immune response (GO:0002830)2.39546509
111JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39150197
112detection of external biotic stimulus (GO:0098581)2.38857891
113hepatocyte apoptotic process (GO:0097284)2.37938643
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.37864911
115NADH metabolic process (GO:0006734)2.37818464
116T cell selection (GO:0045058)2.37754090
117response to host (GO:0075136)2.36955185
118response to host defenses (GO:0052200)2.36955185
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36955185
120translational termination (GO:0006415)2.36235935
121regulation of defense response to virus by virus (GO:0050690)2.36198135
122dendritic cell migration (GO:0036336)2.35755865
123regulation of interleukin-2 biosynthetic process (GO:0045076)2.35490526
124actin nucleation (GO:0045010)2.35308021
125positive regulation of protein homooligomerization (GO:0032464)2.35216296
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.35184602
127regulation of necrotic cell death (GO:0010939)2.34446681
128regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34251809
129regulation of gamma-delta T cell differentiation (GO:0045586)2.33780299
130positive regulation of keratinocyte differentiation (GO:0045618)2.31543058
131T cell apoptotic process (GO:0070231)2.30422434
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.30040418
133positive regulation of interleukin-2 production (GO:0032743)2.29974740
134positive regulation of interferon-beta production (GO:0032728)2.28856100
135ribosomal small subunit biogenesis (GO:0042274)2.28588894
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.28183331
137necroptotic process (GO:0070266)2.28062748
138regulation of response to interferon-gamma (GO:0060330)2.27730380
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25298648
140angiogenesis involved in wound healing (GO:0060055)2.24947178
141negative regulation of growth of symbiont in host (GO:0044130)2.24116186
142negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.24116186
143modulation of growth of symbiont involved in interaction with host (GO:0044144)2.24116186
144regulation of growth of symbiont in host (GO:0044126)2.24116186
145positive regulation by symbiont of host defense response (GO:0052509)2.23286850
146modulation by symbiont of host defense response (GO:0052031)2.23286850
147modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.23286850
148modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.23286850
149positive regulation by organism of defense response of other organism involved in symbiotic interact2.23286850
150modulation by symbiont of host immune response (GO:0052553)2.23286850
151regulation of cellular extravasation (GO:0002691)2.22745551
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.22460201
153negative regulation of viral genome replication (GO:0045071)2.22387135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.75740286
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.61228206
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.26392282
4E2F7_22180533_ChIP-Seq_HELA_Human3.14149376
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.91486730
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63311170
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59516051
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57578264
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.47062145
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46209368
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.39837676
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36799516
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28456679
14* LXR_22292898_ChIP-Seq_THP-1_Human2.25509845
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22324300
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17597276
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15328328
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15320403
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13295300
20VDR_21846776_ChIP-Seq_THP-1_Human2.11798525
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10709105
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03773578
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03315499
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.03040458
25SPI1_23547873_ChIP-Seq_NB4_Human1.99692728
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92257448
27RACK7_27058665_Chip-Seq_MCF-7_Human1.89412440
28ZNF263_19887448_ChIP-Seq_K562_Human1.87691245
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86366517
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84763601
31SCL_19346495_ChIP-Seq_HPC-7_Human1.83986218
32MYC_22102868_ChIP-Seq_BL_Human1.79888730
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78218498
34MAF_26560356_Chip-Seq_TH1_Human1.78139692
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76595062
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76438452
37* MYB_26560356_Chip-Seq_TH2_Human1.70853653
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69243932
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68249778
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67766682
41* VDR_24763502_ChIP-Seq_THP-1_Human1.66659116
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64846280
43GATA1_22025678_ChIP-Seq_K562_Human1.64698215
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63712610
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60622905
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57959133
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55926607
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54138080
49* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52033463
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.51703122
51MYB_26560356_Chip-Seq_TH1_Human1.51396519
52P68_20966046_ChIP-Seq_HELA_Human1.43949576
53* MYC_18555785_ChIP-Seq_MESCs_Mouse1.43691787
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42970586
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42872267
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.41216777
57* BCOR_27268052_Chip-Seq_Bcells_Human1.39260097
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38621425
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.37061168
60* BCL6_27268052_Chip-Seq_Bcells_Human1.36422076
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36329464
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35798258
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33573032
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33302015
65KDM2B_26808549_Chip-Seq_DND41_Human1.32361725
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31821363
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31785608
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.30652019
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.30533397
70CIITA_25753668_ChIP-Seq_RAJI_Human1.30500239
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29465951
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28443845
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.27041077
74UTX_26944678_Chip-Seq_JUKART_Human1.26222053
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24542688
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21670676
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21462679
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20263621
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20219153
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19355682
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18831138
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18255494
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17823837
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17545750
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.17420863
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17147475
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16832556
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16667322
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.16609920
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.16154190
91VDR_23849224_ChIP-Seq_CD4+_Human1.15846987
92MAF_26560356_Chip-Seq_TH2_Human1.14894419
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14542746
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14183800
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13914575
96NCOR1_26117541_ChIP-Seq_K562_Human1.13783569
97RXR_22158963_ChIP-Seq_LIVER_Mouse1.13043616
98SPI1_23127762_ChIP-Seq_K562_Human1.12802262
99RUNX_20019798_ChIP-Seq_JUKART_Human1.12452850
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12431475
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12159825
102XRN2_22483619_ChIP-Seq_HELA_Human1.11724498
103* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11424609
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.11114624
105PU_27001747_Chip-Seq_BMDM_Mouse1.10727662
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10567348
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07297744
108* TCF7_22412390_ChIP-Seq_EML_Mouse1.06771281
109ATF3_27146783_Chip-Seq_COLON_Human1.05839238
110SMC4_20622854_ChIP-Seq_HELA_Human1.04417632
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04047188
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.03517938
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03464174
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02939890
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02412738
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00144659
117ETS1_20019798_ChIP-Seq_JURKAT_Human1.00063204
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99151753
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99061119
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97399439
121TFEB_21752829_ChIP-Seq_HELA_Human0.97009923
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96672059
123* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96301763
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96089299
125DCP1A_22483619_ChIP-Seq_HELA_Human0.95721472
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95516766
127GATA3_27048872_Chip-Seq_THYMUS_Human0.95398539
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93169954
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93047873
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92830253
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92428816
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91795743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.69551759
2MP0000685_abnormal_immune_system3.43679456
3MP0002148_abnormal_hypersensitivity_rea2.90040006
4MP0009785_altered_susceptibility_to2.86869554
5MP0003436_decreased_susceptibility_to2.67046929
6MP0005671_abnormal_response_to2.64549472
7MP0001790_abnormal_immune_system2.61569276
8MP0005387_immune_system_phenotype2.61569276
9MP0005000_abnormal_immune_tolerance2.43997181
10MP0005025_abnormal_response_to2.41702339
11MP0001800_abnormal_humoral_immune2.41156099
12MP0002452_abnormal_antigen_presenting2.27512782
13MP0001853_heart_inflammation2.25262270
14MP0002419_abnormal_innate_immunity2.21877677
15MP0002138_abnormal_hepatobiliary_system2.14983085
16MP0010234_abnormal_vibrissa_follicle2.14557149
17MP0004510_myositis2.14397921
18MP0002166_altered_tumor_susceptibility2.14164260
19MP0002723_abnormal_immune_serum2.12841643
20MP0001819_abnormal_immune_cell2.02114098
21MP0002420_abnormal_adaptive_immunity2.00497286
22MP0002396_abnormal_hematopoietic_system1.93242439
23MP0001873_stomach_inflammation1.88576733
24MP0009840_abnormal_foam_cell1.82594442
25MP0006082_CNS_inflammation1.82141286
26MP0003724_increased_susceptibility_to1.81594038
27MP0002254_reproductive_system_inflammat1.78251643
28MP0001348_abnormal_lacrimal_gland1.77520130
29MP0005310_abnormal_salivary_gland1.77481570
30MP0002405_respiratory_system_inflammati1.76353902
31MP0009333_abnormal_splenocyte_physiolog1.74472886
32MP0002006_tumorigenesis1.73083807
33MP0010155_abnormal_intestine_physiology1.72690568
34MP0003191_abnormal_cellular_cholesterol1.71582038
35MP0008260_abnormal_autophagy1.68861274
36MP0002398_abnormal_bone_marrow1.68242740
37MP0003763_abnormal_thymus_physiology1.65743833
38MP0000716_abnormal_immune_system1.65400942
39MP0003303_peritoneal_inflammation1.64901290
40MP0005464_abnormal_platelet_physiology1.64480196
41MP0001845_abnormal_inflammatory_respons1.62028946
42MP0002796_impaired_skin_barrier1.55460482
43MP0001545_abnormal_hematopoietic_system1.48781805
44MP0005397_hematopoietic_system_phenotyp1.48781805
45MP0004947_skin_inflammation1.45424314
46MP0000689_abnormal_spleen_morphology1.44436123
47MP0002429_abnormal_blood_cell1.43636599
48MP0008469_abnormal_protein_level1.42309364
49MP0002722_abnormal_immune_system1.42116891
50MP0002139_abnormal_hepatobiliary_system1.42004624
51MP0005058_abnormal_lysosome_morphology1.41756278
52MP0004264_abnormal_extraembryonic_tissu1.41170721
53MP0003183_abnormal_peptide_metabolism1.40107998
54MP0003300_gastrointestinal_ulcer1.38123179
55MP0003186_abnormal_redox_activity1.32408654
56MP0000490_abnormal_crypts_of1.29269811
57MP0000858_altered_metastatic_potential1.28214040
58MP0001533_abnormal_skeleton_physiology1.27710332
59MP0008057_abnormal_DNA_replication1.27332062
60MP0010352_gastrointestinal_tract_polyps1.26675240
61MP0009764_decreased_sensitivity_to1.24294133
62MP0006054_spinal_hemorrhage1.18274322
63MP0000343_altered_response_to1.14244023
64MP0005501_abnormal_skin_physiology1.12854101
65MP0003866_abnormal_defecation1.07066652
66MP0005166_decreased_susceptibility_to1.06091725
67MP0003693_abnormal_embryo_hatching1.05018045
68MP0003448_altered_tumor_morphology1.04866079
69MP0004808_abnormal_hematopoietic_stem1.04542109
70MP0003172_abnormal_lysosome_physiology1.03633774
71MP0002163_abnormal_gland_morphology0.99541953
72MP0003806_abnormal_nucleotide_metabolis0.99484488
73MP0000465_gastrointestinal_hemorrhage0.98124950
74MP0005076_abnormal_cell_differentiation0.97113977
75MP0001346_abnormal_lacrimal_gland0.95209160
76MP0003566_abnormal_cell_adhesion0.94405453
77MP0002877_abnormal_melanocyte_morpholog0.93533289
78MP0004381_abnormal_hair_follicle0.92264658
79MP0004185_abnormal_adipocyte_glucose0.91723581
80MP0003656_abnormal_erythrocyte_physiolo0.90610338
81MP0009278_abnormal_bone_marrow0.89686171
82MP0000703_abnormal_thymus_morphology0.87496237
83MP0009763_increased_sensitivity_to0.87230714
84MP0000678_abnormal_parathyroid_gland0.86376990
85MP0003828_pulmonary_edema0.84719621
86MP0001216_abnormal_epidermal_layer0.83696920
87MP0002933_joint_inflammation0.83386077
88MP0002019_abnormal_tumor_incidence0.83040218
89MP0001881_abnormal_mammary_gland0.81947838
90MP0004782_abnormal_surfactant_physiolog0.81646933
91MP0000609_abnormal_liver_physiology0.81401396
92MP0009643_abnormal_urine_homeostasis0.81383760
93MP0006036_abnormal_mitochondrial_physio0.78186777
94MP0005165_increased_susceptibility_to0.78042476
95MP0004858_abnormal_nervous_system0.77141900
96MP0005319_abnormal_enzyme/_coenzyme0.76412891
97MP0003453_abnormal_keratinocyte_physiol0.74404660
98MP0005174_abnormal_tail_pigmentation0.74284521
99MP0003075_altered_response_to0.73655307
100MP0002132_abnormal_respiratory_system0.72448629
101MP0002136_abnormal_kidney_physiology0.72441607
102MP0008007_abnormal_cellular_replicative0.72346672
103MP0001663_abnormal_digestive_system0.71139407
104MP0000249_abnormal_blood_vessel0.70894070
105MP0001727_abnormal_embryo_implantation0.70279091
106MP0009931_abnormal_skin_appearance0.70052377
107MP0005666_abnormal_adipose_tissue0.70002495
108MP0010307_abnormal_tumor_latency0.69976721
109MP0008874_decreased_physiological_sensi0.68047596
110MP0005381_digestive/alimentary_phenotyp0.67784285
111MP0005023_abnormal_wound_healing0.67632966
112MP0000598_abnormal_liver_morphology0.67046670
113MP0002098_abnormal_vibrissa_morphology0.64912021
114MP0005075_abnormal_melanosome_morpholog0.63547910
115MP0005584_abnormal_enzyme/coenzyme_acti0.61795176
116MP0005360_urolithiasis0.61193546
117MP0005083_abnormal_biliary_tract0.59367058
118MP0003077_abnormal_cell_cycle0.59074208
119MP0002009_preneoplasia0.58613095
120MP0002998_abnormal_bone_remodeling0.56579388
121MP0005451_abnormal_body_composition0.56291017
122MP0001666_abnormal_nutrient_absorption0.55776650
123MP0002277_abnormal_respiratory_mucosa0.54928564

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.58988625
2Recurrent bacterial skin infections (HP:0005406)4.50776052
3Eczematoid dermatitis (HP:0000976)4.49884378
4Elevated erythrocyte sedimentation rate (HP:0003565)4.45822901
5Myositis (HP:0100614)4.15729201
6Thrombocytosis (HP:0001894)4.01988418
7Chronic otitis media (HP:0000389)4.01178633
8Recurrent gram-negative bacterial infections (HP:0005420)3.66162512
9Recurrent fungal infections (HP:0002841)3.39304203
10Abnormality of glycolipid metabolism (HP:0010969)3.38790170
11Abnormality of liposaccharide metabolism (HP:0010968)3.38790170
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.38790170
13Orchitis (HP:0100796)3.37128303
14Recurrent skin infections (HP:0001581)3.28462725
15Abnormality of macrophages (HP:0004311)3.27252258
16Recurrent viral infections (HP:0004429)3.20962063
17Autoimmune thrombocytopenia (HP:0001973)3.17521496
18Hypertensive crisis (HP:0100735)3.08820394
19Petechiae (HP:0000967)3.03157678
20Retrobulbar optic neuritis (HP:0100654)3.01819960
21Optic neuritis (HP:0100653)3.01819960
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.01035399
23Recurrent bronchitis (HP:0002837)2.96324395
24Vacuolated lymphocytes (HP:0001922)2.95121542
25Vasculitis (HP:0002633)2.92762579
26Interstitial pulmonary disease (HP:0006530)2.92260933
27Dysostosis multiplex (HP:0000943)2.91658952
28Abnormality of T cell physiology (HP:0011840)2.91023266
29Chronic mucocutaneous candidiasis (HP:0002728)2.79187058
30Recurrent cutaneous fungal infections (HP:0011370)2.79187058
31IgM deficiency (HP:0002850)2.76137322
32Cellulitis (HP:0100658)2.74683933
33Mediastinal lymphadenopathy (HP:0100721)2.72674070
34Pustule (HP:0200039)2.66269502
35Inflammation of the large intestine (HP:0002037)2.66125818
36Nasal polyposis (HP:0100582)2.63798430
37Meningitis (HP:0001287)2.62477214
38Abnormality of the nasal mucosa (HP:0000433)2.60504608
39Gastrointestinal inflammation (HP:0004386)2.56346141
40Gastrointestinal infarctions (HP:0005244)2.56137196
41Colitis (HP:0002583)2.54385309
42Ragged-red muscle fibers (HP:0003200)2.53331708
43Hypergammaglobulinemia (HP:0010702)2.51635245
44Recurrent sinusitis (HP:0011108)2.49886968
45Urticaria (HP:0001025)2.47264095
46Abnormal number of erythroid precursors (HP:0012131)2.46764548
47Arterial thrombosis (HP:0004420)2.46090212
48Agammaglobulinemia (HP:0004432)2.45794660
49Increased IgM level (HP:0003496)2.45328129
50Periodontitis (HP:0000704)2.43817121
51Abnormality of cells of the erythroid lineage (HP:0012130)2.42383818
52Chronic obstructive pulmonary disease (HP:0006510)2.41826175
53Obstructive lung disease (HP:0006536)2.41826175
54Systemic lupus erythematosus (HP:0002725)2.39870674
55Loss of speech (HP:0002371)2.38572934
56Granulocytopenia (HP:0001913)2.36907258
57Abnormality of T cells (HP:0002843)2.36453635
58Keratoconjunctivitis (HP:0001096)2.35624775
59Pulmonary infiltrates (HP:0002113)2.34711821
60Gingival bleeding (HP:0000225)2.34626321
61Eosinophilia (HP:0001880)2.33970644
62Spontaneous hematomas (HP:0007420)2.31816052
63Restrictive lung disease (HP:0002091)2.31814077
64Distal lower limb muscle weakness (HP:0009053)2.31753269
65Gastrointestinal stroma tumor (HP:0100723)2.31008134
66Leukocytosis (HP:0001974)2.28776749
67Increased IgE level (HP:0003212)2.28231467
68Panhypogammaglobulinemia (HP:0003139)2.27624369
69Gingivitis (HP:0000230)2.27411404
70Testicular atrophy (HP:0000029)2.27080596
71Purpura (HP:0000979)2.23174193
72Keratoconjunctivitis sicca (HP:0001097)2.20631321
73Chest pain (HP:0100749)2.18530499
74Seborrheic dermatitis (HP:0001051)2.17948307
75Hematochezia (HP:0002573)2.17715883
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.16338712
77Hepatosplenomegaly (HP:0001433)2.16228903
78Encephalitis (HP:0002383)2.14405909
79Chronic sinusitis (HP:0011109)2.13869196
80Epistaxis (HP:0000421)2.13054465
81Basal ganglia calcification (HP:0002135)2.12903801
82Hemoptysis (HP:0002105)2.12023426
83Rhabdomyolysis (HP:0003201)2.10092309
84Reduced antithrombin III activity (HP:0001976)2.08110347
85Osteomyelitis (HP:0002754)2.05697072
86Skin ulcer (HP:0200042)2.04864278
87Autoimmune hemolytic anemia (HP:0001890)2.04223265
88Lymphopenia (HP:0001888)2.03948251
89Abnormality of small intestinal villus morphology (HP:0011472)2.02833131
90Villous atrophy (HP:0011473)2.02833131
91Bulbar palsy (HP:0001283)2.01949063
92Hemorrhage of the eye (HP:0011885)2.01343899
93Centrally nucleated skeletal muscle fibers (HP:0003687)2.01337905
94Abnormality of polysaccharide metabolism (HP:0011012)2.00661865
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00661865
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00661865
97Urinary glycosaminoglycan excretion (HP:0003541)2.00323876
98Mucopolysacchariduria (HP:0008155)2.00323876
99Fatigue (HP:0012378)2.00210300
100Recurrent lower respiratory tract infections (HP:0002783)1.99396239
101Abnormality of eosinophils (HP:0001879)1.98478029
102J-shaped sella turcica (HP:0002680)1.98449611
103Recurrent pneumonia (HP:0006532)1.98446654
104Emphysema (HP:0002097)1.98037022
105Myocardial infarction (HP:0001658)1.97862644
106Skin rash (HP:0000988)1.97794897
107Flat acetabular roof (HP:0003180)1.97601388
108Verrucae (HP:0200043)1.97140644
109Papilloma (HP:0012740)1.97140644
110Neutropenia (HP:0001875)1.96061895
111Reticulocytopenia (HP:0001896)1.95511862
112Polycythemia (HP:0001901)1.94956537
113IgA deficiency (HP:0002720)1.93976758
114Increased muscle lipid content (HP:0009058)1.93285667
115Abnormality of T cell number (HP:0011839)1.93282563
116Increased serum ferritin (HP:0003281)1.92677726
117Abnormality of iron homeostasis (HP:0011031)1.91535431
118IgG deficiency (HP:0004315)1.89977467
119Peritonitis (HP:0002586)1.88490952
120Myopathic facies (HP:0002058)1.87603684
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.86359200
122Thin bony cortex (HP:0002753)1.85876300
123Abnormal platelet function (HP:0011869)1.85809813
124Impaired platelet aggregation (HP:0003540)1.85809813
125Osteolytic defects of the hand bones (HP:0009699)1.85550864
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.85550864
127Poor head control (HP:0002421)1.85360263
128Progressive neurologic deterioration (HP:0002344)1.84949421
129Exertional dyspnea (HP:0002875)1.84716043
130Progressive muscle weakness (HP:0003323)1.83928552
131Malnutrition (HP:0004395)1.83281519
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82786017
133Increased cerebral lipofuscin (HP:0011813)1.81114802
134Polyneuropathy (HP:0001271)1.77491332
135Abnormality of the prostate (HP:0008775)1.77335421
136Anorexia (HP:0002039)1.76987119
137Axonal loss (HP:0003447)1.76091217
138Thoracic kyphosis (HP:0002942)1.75919163
139Chronic diarrhea (HP:0002028)1.74740149
140Prolonged bleeding time (HP:0003010)1.74726376
141Premature loss of primary teeth (HP:0006323)1.73370075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.37348898
2MAP4K13.20167960
3TBK12.89218297
4TYK22.84357554
5SMG12.77722817
6PIM22.67065005
7PRPF4B2.56239462
8IRAK42.54492114
9BLK2.48355736
10NME22.35874998
11ERN12.35177751
12IKBKB2.35172235
13JAK32.33991984
14KIT2.19366090
15IRAK32.16860628
16IKBKE2.01308627
17MAP2K31.84357248
18FLT31.82402313
19TAOK11.77383415
20CSF1R1.74073106
21EPHB11.71074861
22BTK1.70918814
23TAOK21.60420441
24CHUK1.60130892
25ZAP701.58202206
26LRRK21.57683855
27KDR1.49876977
28TEC1.48975856
29JAK11.45820598
30BCKDK1.42565761
31TGFBR21.42116186
32MST41.41805081
33RPS6KA41.39173694
34TRIB31.38333830
35TAOK31.38309832
36STK101.37833674
37VRK21.35028820
38SYK1.32822129
39NEK91.29725763
40FGFR41.25171651
41ICK1.21815817
42PIM11.21099168
43PKN21.19523135
44TTN1.16702773
45TNK21.09910781
46MST1R1.04546083
47MAP3K31.03187077
48TGFBR11.01898240
49RIPK40.99305267
50TESK20.96535950
51MAP3K10.94716141
52SCYL20.94267874
53CSK0.94019811
54PIK3CG0.93993293
55TXK0.93580916
56STK40.93553205
57MATK0.92570669
58PRKD20.90452100
59EIF2AK30.90395719
60EEF2K0.88801678
61PAK40.86988990
62NLK0.86440909
63STK160.85810676
64LYN0.85659655
65JAK20.84761225
66EPHA30.83630166
67PTK60.81943951
68MAP3K130.79890714
69ITK0.79722889
70PDPK10.79635546
71LCK0.79210711
72CDK120.78962717
73RPS6KB20.76640276
74TLK10.75499565
75MAP3K110.73512612
76EIF2AK10.73451978
77MAPKAPK30.72281614
78HCK0.70669580
79IRAK20.70376896
80TESK10.69635673
81MAPKAPK20.69432134
82ABL20.67894130
83PRKCI0.67083647
84CDC42BPA0.66619018
85DAPK10.65680582
86MAP3K80.63533737
87MYLK0.61855141
88VRK10.61599966
89NME10.58470745
90MAP2K60.57883635
91RIPK10.57474818
92HIPK20.57319450
93PDK10.57150020
94GRK60.57025506
95ACVR1B0.55060017
96TRPM70.53425909
97ILK0.53294841
98BUB10.51821637
99CDK40.51795916
100CAMK1D0.51723782
101EIF2AK20.51518715
102MAP2K20.51043471
103CLK10.51019428
104RPS6KC10.50730417
105RPS6KL10.50730417
106SIK10.47035798
107DYRK30.46750089
108RPS6KA60.45853082
109PRKCD0.45475565
110MAP3K100.45145603
111STK240.44371513
112DAPK30.44229470
113FES0.42253060
114MAPK110.42119675
115WEE10.41747327
116FGR0.41665063
117RPS6KA20.41375533
118BMPR20.40996917
119CDK70.40066276
120MARK20.39980949
121ARAF0.39755476
122PBK0.38738778
123ABL10.38236205
124RPS6KA50.37609422
125TIE10.37434854
126MAPK120.34796433
127IRAK10.34070209
128SIK30.33883299
129SIK20.33861348
130BRSK20.33649230
131EPHA20.33584946
132MARK30.32886200
133PRKD10.32399863
134DYRK1B0.32211867
135PRKCQ0.30883200
136MTOR0.30429933

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.50413272
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.33228602
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32802059
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.32795307
5Allograft rejection_Homo sapiens_hsa053302.29681121
6Antigen processing and presentation_Homo sapiens_hsa046122.25687711
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.22830781
8Primary immunodeficiency_Homo sapiens_hsa053402.20429072
9DNA replication_Homo sapiens_hsa030302.11867524
10Ribosome_Homo sapiens_hsa030102.09088594
11Graft-versus-host disease_Homo sapiens_hsa053321.85166564
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80578335
13Measles_Homo sapiens_hsa051621.80505425
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77488253
15Legionellosis_Homo sapiens_hsa051341.76788201
16Proteasome_Homo sapiens_hsa030501.76058315
17Fructose and mannose metabolism_Homo sapiens_hsa000511.70211275
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63719045
19Osteoclast differentiation_Homo sapiens_hsa043801.56412220
20Herpes simplex infection_Homo sapiens_hsa051681.53178314
21Other glycan degradation_Homo sapiens_hsa005111.52757377
22B cell receptor signaling pathway_Homo sapiens_hsa046621.51918877
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51759211
24Staphylococcus aureus infection_Homo sapiens_hsa051501.48891263
25Toxoplasmosis_Homo sapiens_hsa051451.43017370
26Pertussis_Homo sapiens_hsa051331.40218823
27Apoptosis_Homo sapiens_hsa042101.37934562
28Influenza A_Homo sapiens_hsa051641.37559910
29Viral myocarditis_Homo sapiens_hsa054161.36742201
30Base excision repair_Homo sapiens_hsa034101.31048390
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.26005989
32Mismatch repair_Homo sapiens_hsa034301.23690599
33Shigellosis_Homo sapiens_hsa051311.19510987
34Tuberculosis_Homo sapiens_hsa051521.18657392
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17223168
36Malaria_Homo sapiens_hsa051441.15498202
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.14769512
38TNF signaling pathway_Homo sapiens_hsa046681.14381761
39Autoimmune thyroid disease_Homo sapiens_hsa053201.14024447
40Hematopoietic cell lineage_Homo sapiens_hsa046401.13909919
41Pentose phosphate pathway_Homo sapiens_hsa000301.13235461
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.12447559
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09371063
44One carbon pool by folate_Homo sapiens_hsa006701.08436692
45Asthma_Homo sapiens_hsa053101.06777498
46Lysosome_Homo sapiens_hsa041421.05533153
47Systemic lupus erythematosus_Homo sapiens_hsa053221.02731392
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02471632
49Homologous recombination_Homo sapiens_hsa034400.98456111
50Folate biosynthesis_Homo sapiens_hsa007900.96574958
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96365020
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.92884797
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91521843
54Protein export_Homo sapiens_hsa030600.88177403
55Acute myeloid leukemia_Homo sapiens_hsa052210.87017664
56Epstein-Barr virus infection_Homo sapiens_hsa051690.82070301
57p53 signaling pathway_Homo sapiens_hsa041150.81863989
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81156448
59Salmonella infection_Homo sapiens_hsa051320.80834573
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80301307
61Sulfur relay system_Homo sapiens_hsa041220.78873211
62Hepatitis B_Homo sapiens_hsa051610.77080174
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76238105
64Pyrimidine metabolism_Homo sapiens_hsa002400.74323312
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74041664
66Chemokine signaling pathway_Homo sapiens_hsa040620.73754120
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73541829
68N-Glycan biosynthesis_Homo sapiens_hsa005100.72803519
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71181719
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69493103
71Type I diabetes mellitus_Homo sapiens_hsa049400.68749816
72Histidine metabolism_Homo sapiens_hsa003400.68732640
73Bladder cancer_Homo sapiens_hsa052190.68027885
74Tryptophan metabolism_Homo sapiens_hsa003800.65950461
75Hepatitis C_Homo sapiens_hsa051600.64589855
76Small cell lung cancer_Homo sapiens_hsa052220.63805230
77Nucleotide excision repair_Homo sapiens_hsa034200.61929222
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60108562
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59878322
80Phenylalanine metabolism_Homo sapiens_hsa003600.59599753
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58714403
82Rheumatoid arthritis_Homo sapiens_hsa053230.58494550
83Fatty acid degradation_Homo sapiens_hsa000710.57955878
84Viral carcinogenesis_Homo sapiens_hsa052030.57890870
85African trypanosomiasis_Homo sapiens_hsa051430.56763686
86Galactose metabolism_Homo sapiens_hsa000520.55913823
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55868944
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55270415
89Caffeine metabolism_Homo sapiens_hsa002320.55258583
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54839314
91Glutathione metabolism_Homo sapiens_hsa004800.52629184
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52318909
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52154645
94Biosynthesis of amino acids_Homo sapiens_hsa012300.51672508
95T cell receptor signaling pathway_Homo sapiens_hsa046600.51127165
96Vibrio cholerae infection_Homo sapiens_hsa051100.50768770
97Selenocompound metabolism_Homo sapiens_hsa004500.50591141
98VEGF signaling pathway_Homo sapiens_hsa043700.50287177
99Non-small cell lung cancer_Homo sapiens_hsa052230.49092921
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48789772
101Carbon metabolism_Homo sapiens_hsa012000.48782325
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.48143844
103Phagosome_Homo sapiens_hsa041450.48026150
104Pancreatic cancer_Homo sapiens_hsa052120.47809108
105Sphingolipid metabolism_Homo sapiens_hsa006000.46485203
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.46438504
107Sulfur metabolism_Homo sapiens_hsa009200.46121644
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45666063
109Chronic myeloid leukemia_Homo sapiens_hsa052200.45369594
110HTLV-I infection_Homo sapiens_hsa051660.44272681
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44244773
112Endocytosis_Homo sapiens_hsa041440.43869248
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.42366125
114RNA polymerase_Homo sapiens_hsa030200.41512433
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41300574
116Platelet activation_Homo sapiens_hsa046110.41194879
117Vitamin digestion and absorption_Homo sapiens_hsa049770.41079645
118beta-Alanine metabolism_Homo sapiens_hsa004100.40998259
119Complement and coagulation cascades_Homo sapiens_hsa046100.40627771
120Non-homologous end-joining_Homo sapiens_hsa034500.40434078
121Renin-angiotensin system_Homo sapiens_hsa046140.40277883
122Peroxisome_Homo sapiens_hsa041460.39765067
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39703440
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39319172
125Insulin resistance_Homo sapiens_hsa049310.38077876
126Notch signaling pathway_Homo sapiens_hsa043300.31679522
127Prion diseases_Homo sapiens_hsa050200.29753692
128HIF-1 signaling pathway_Homo sapiens_hsa040660.29133362
129Prolactin signaling pathway_Homo sapiens_hsa049170.26944756

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