SYNGR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.77507753
2synaptic vesicle exocytosis (GO:0016079)5.65746289
3vocalization behavior (GO:0071625)5.41662918
4neuron cell-cell adhesion (GO:0007158)5.39814516
5glutamate secretion (GO:0014047)5.06394049
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01313444
7sodium ion export (GO:0071436)4.96811798
8regulation of synaptic vesicle exocytosis (GO:2000300)4.89376515
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86314332
10synaptic vesicle maturation (GO:0016188)4.77792060
11protein localization to synapse (GO:0035418)4.74218776
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.69967963
13regulation of glutamate receptor signaling pathway (GO:1900449)4.66645020
14cerebellar granule cell differentiation (GO:0021707)4.61093042
15neurotransmitter secretion (GO:0007269)4.54872431
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47752492
17locomotory exploration behavior (GO:0035641)4.36583597
18regulation of synaptic vesicle transport (GO:1902803)4.33415832
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.27423467
20neuronal action potential propagation (GO:0019227)4.21468754
21neuronal ion channel clustering (GO:0045161)4.18775002
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.17565543
23potassium ion homeostasis (GO:0055075)4.08228072
24positive regulation of dendritic spine morphogenesis (GO:0061003)4.03454827
25proline transport (GO:0015824)4.01997690
26exploration behavior (GO:0035640)4.00112459
27neuron-neuron synaptic transmission (GO:0007270)3.99210208
28neurotransmitter-gated ion channel clustering (GO:0072578)3.91205952
29positive regulation of dendritic spine development (GO:0060999)3.89649910
30synaptic transmission, glutamatergic (GO:0035249)3.85964708
31glutamate receptor signaling pathway (GO:0007215)3.83650434
32L-amino acid import (GO:0043092)3.81500063
33neurotransmitter transport (GO:0006836)3.81489133
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80652579
35regulation of neuronal synaptic plasticity (GO:0048168)3.74387866
36regulation of voltage-gated calcium channel activity (GO:1901385)3.72512446
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72471470
38neuron recognition (GO:0008038)3.72144143
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71135514
40gamma-aminobutyric acid transport (GO:0015812)3.66061301
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.65684218
42establishment of mitochondrion localization (GO:0051654)3.63690432
43presynaptic membrane assembly (GO:0097105)3.61865599
44regulation of neurotransmitter levels (GO:0001505)3.60521623
45postsynaptic membrane organization (GO:0001941)3.59064492
46regulation of synapse maturation (GO:0090128)3.58912335
47positive regulation of neurotransmitter secretion (GO:0001956)3.57781914
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57498060
49regulation of synapse structural plasticity (GO:0051823)3.57140121
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57109066
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.55651215
52neuromuscular process controlling balance (GO:0050885)3.54761837
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.50906590
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.50200221
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.48876725
56amino acid import (GO:0043090)3.48406549
57auditory behavior (GO:0031223)3.48050907
58regulation of dendritic spine morphogenesis (GO:0061001)3.46989773
59layer formation in cerebral cortex (GO:0021819)3.46777317
60ATP hydrolysis coupled proton transport (GO:0015991)3.46492051
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.46492051
62potassium ion import (GO:0010107)3.45805307
63positive regulation of synapse maturation (GO:0090129)3.45002991
64central nervous system myelination (GO:0022010)3.42286603
65axon ensheathment in central nervous system (GO:0032291)3.42286603
66cell communication by electrical coupling (GO:0010644)3.41624731
67regulation of postsynaptic membrane potential (GO:0060078)3.40231983
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.39949811
69neuromuscular synaptic transmission (GO:0007274)3.39048467
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38646265
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.36792255
72negative regulation of dendrite morphogenesis (GO:0050774)3.36380577
73response to histamine (GO:0034776)3.36307832
74regulation of neurotransmitter secretion (GO:0046928)3.36039175
75presynaptic membrane organization (GO:0097090)3.35934819
76synaptic vesicle endocytosis (GO:0048488)3.35904440
77regulation of ARF protein signal transduction (GO:0032012)3.33745518
78cell differentiation in hindbrain (GO:0021533)3.32500585
79regulation of vesicle fusion (GO:0031338)3.31638418
80mating behavior (GO:0007617)3.29713053
81cerebellar Purkinje cell layer development (GO:0021680)3.28383702
82activation of protein kinase A activity (GO:0034199)3.28074216
83transferrin transport (GO:0033572)3.27574979
84positive regulation of membrane potential (GO:0045838)3.27566975
85long-term memory (GO:0007616)3.27343127
86dendritic spine organization (GO:0097061)3.26857322
87synapse assembly (GO:0007416)3.26700638
88cellular sodium ion homeostasis (GO:0006883)3.26601405
89long-term synaptic potentiation (GO:0060291)3.25491359
90transmission of nerve impulse (GO:0019226)3.24400386
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.23526347
92mitochondrion transport along microtubule (GO:0047497)3.23526347
93regulation of glutamate secretion (GO:0014048)3.23480127
94regulation of neurotransmitter transport (GO:0051588)3.22719962
95positive regulation of neurotransmitter transport (GO:0051590)3.22172781
96neuromuscular process controlling posture (GO:0050884)3.21425215
97regulation of synaptic transmission (GO:0050804)3.20333315
98cell migration in hindbrain (GO:0021535)3.18062809
99positive regulation of synapse assembly (GO:0051965)3.16800986
100membrane depolarization during action potential (GO:0086010)3.15876563
101axonal fasciculation (GO:0007413)3.15568515
102regulation of synaptic plasticity (GO:0048167)3.13216878
103cerebellar Purkinje cell differentiation (GO:0021702)3.12256304
104regulation of dendritic spine development (GO:0060998)3.12126892
105behavioral response to cocaine (GO:0048148)3.12085385
106membrane depolarization (GO:0051899)3.11365752
107negative regulation of microtubule polymerization (GO:0031115)3.10689731
108establishment of synaptic vesicle localization (GO:0097480)3.09970755
109synaptic vesicle transport (GO:0048489)3.09970755
110synaptic transmission (GO:0007268)3.08637083
111adult walking behavior (GO:0007628)3.08395886
112neurofilament cytoskeleton organization (GO:0060052)3.07260687
113synaptic transmission, dopaminergic (GO:0001963)3.06125867
114ferric iron transport (GO:0015682)3.02905557
115trivalent inorganic cation transport (GO:0072512)3.02905557
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02396640
117membrane hyperpolarization (GO:0060081)3.02354497
118prepulse inhibition (GO:0060134)3.02053033
119dendritic spine morphogenesis (GO:0060997)3.00968006
120behavioral fear response (GO:0001662)2.99469223
121behavioral defense response (GO:0002209)2.99469223
122regulation of synaptic transmission, GABAergic (GO:0032228)2.99456576
123striatum development (GO:0021756)2.97332964
124negative regulation of dendrite development (GO:2000171)2.96612972
125innervation (GO:0060384)2.95556818
126social behavior (GO:0035176)2.94919641
127intraspecies interaction between organisms (GO:0051703)2.94919641
128fear response (GO:0042596)2.94732147
129cellular potassium ion homeostasis (GO:0030007)2.94563643
130regulation of protein kinase A signaling (GO:0010738)2.93614270
131behavioral response to ethanol (GO:0048149)2.93459348
132positive regulation of synaptic transmission (GO:0050806)2.93039984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97183464
2GBX2_23144817_ChIP-Seq_PC3_Human4.15281048
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23413477
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04478127
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00653710
6REST_21632747_ChIP-Seq_MESCs_Mouse2.86451111
7TAF15_26573619_Chip-Seq_HEK293_Human2.70440215
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64998848
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63262029
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62086850
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59111160
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59111160
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.55584391
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54141395
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50445184
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44586062
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42460538
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.38203443
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.31037088
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28832230
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22700854
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.22573370
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20535507
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15403010
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.10474751
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09174575
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06704517
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06437381
29DROSHA_22980978_ChIP-Seq_HELA_Human2.02079268
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.01675832
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.00740443
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92997763
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86702583
34SMAD4_21799915_ChIP-Seq_A2780_Human1.83270928
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80134574
36AR_21572438_ChIP-Seq_LNCaP_Human1.78664674
37KDM2B_26808549_Chip-Seq_K562_Human1.75255592
38P300_19829295_ChIP-Seq_ESCs_Human1.69518004
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69425451
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64184905
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62326630
42ZNF274_21170338_ChIP-Seq_K562_Hela1.60125571
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60015573
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58533535
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56665972
46IGF1R_20145208_ChIP-Seq_DFB_Human1.55168411
47CTCF_27219007_Chip-Seq_Bcells_Human1.51268336
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50147912
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49748392
50TET1_21490601_ChIP-Seq_MESCs_Mouse1.47955363
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.45264030
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45111184
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42790955
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.42406766
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42195848
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39996303
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.38933998
58* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38795663
59AR_25329375_ChIP-Seq_VCAP_Human1.38784321
60RNF2_27304074_Chip-Seq_NSC_Mouse1.38071346
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.37544349
62OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36109164
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35583648
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35410516
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34104664
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.33580490
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31951343
68VDR_22108803_ChIP-Seq_LS180_Human1.30959904
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.30724596
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30334872
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29489208
72FUS_26573619_Chip-Seq_HEK293_Human1.27823382
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27792476
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.26114624
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24208479
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23845697
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22355135
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22303869
79STAT3_23295773_ChIP-Seq_U87_Human1.21065792
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20869017
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19161447
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18333474
83JUN_21703547_ChIP-Seq_K562_Human1.15350003
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.14562136
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13317810
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.11633439
87TCF4_23295773_ChIP-Seq_U87_Human1.10796427
88ER_23166858_ChIP-Seq_MCF-7_Human1.10536927
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10521500
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09960434
91* OCT4_19829295_ChIP-Seq_ESCs_Human1.09505552
92RUNX2_22187159_ChIP-Seq_PCA_Human1.08041422
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07571797
94AR_19668381_ChIP-Seq_PC3_Human1.06651115
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05228032
96LXR_22292898_ChIP-Seq_THP-1_Human1.02390486
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02297916
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00353616
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99038020
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97621916
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.97028912
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96777264
103SMC4_20622854_ChIP-Seq_HELA_Human0.95628348
104YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95550267
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95023170
106AHR_22903824_ChIP-Seq_MCF-7_Human0.94654850
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.94053931
108BCAT_22108803_ChIP-Seq_LS180_Human0.93137541
109* DPY_21335234_ChIP-Seq_ESCs_Mouse0.91961368
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90658369
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.90600971
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90572588
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90376132
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90189359
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89600187
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89482914
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88712314
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88712314
119* P68_20966046_ChIP-Seq_HELA_Human0.88171046
120KDM2B_26808549_Chip-Seq_REH_Human0.87929600
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.87409367
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.86852022
123* CREB1_26743006_Chip-Seq_LNCaP_Human0.85823696
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85212504
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84088716
126CBP_20019798_ChIP-Seq_JUKART_Human0.84032283
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84032283
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83086136
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.82491735
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82058977
131NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81397121
132MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79983291
133KLF4_19829295_ChIP-Seq_ESCs_Human0.77157738
134SOX9_26525672_Chip-Seq_HEART_Mouse0.76088161
135SMAD4_21741376_ChIP-Seq_ESCs_Human0.75526743
136RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75214288
137TET1_21451524_ChIP-Seq_MESCs_Mouse0.73956716
138POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.72764036
139MYC_19915707_ChIP-ChIP_AK7_Human0.69900373
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.69149599
141MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.68405152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.19292567
2MP0003880_abnormal_central_pattern5.06324374
3MP0003635_abnormal_synaptic_transmissio3.84320335
4MP0001968_abnormal_touch/_nociception3.57928728
5MP0004270_analgesia3.42594795
6MP0009745_abnormal_behavioral_response3.34162397
7MP0002064_seizures3.13174577
8MP0002736_abnormal_nociception_after3.11051204
9MP0002063_abnormal_learning/memory/cond3.09086301
10MP0009046_muscle_twitch3.07840913
11MP0002822_catalepsy3.05767919
12MP0002735_abnormal_chemical_nociception2.99223811
13MP0006276_abnormal_autonomic_nervous2.98066576
14MP0002734_abnormal_mechanical_nocicepti2.84021123
15MP0002572_abnormal_emotion/affect_behav2.78971972
16MP0002272_abnormal_nervous_system2.58502901
17MP0005423_abnormal_somatic_nervous2.57506993
18MP0001529_abnormal_vocalization2.42029003
19MP0002733_abnormal_thermal_nociception2.41003062
20MP0001501_abnormal_sleep_pattern2.35597866
21MP0001440_abnormal_grooming_behavior2.33189036
22MP0001970_abnormal_pain_threshold2.27701119
23MP0001486_abnormal_startle_reflex2.26083669
24MP0002067_abnormal_sensory_capabilities2.10580866
25MP0001905_abnormal_dopamine_level2.06247796
26MP0003122_maternal_imprinting1.98594455
27MP0002184_abnormal_innervation1.97495214
28MP0005386_behavior/neurological_phenoty1.93857702
29MP0004924_abnormal_behavior1.93857702
30MP0004858_abnormal_nervous_system1.79636012
31MP0001984_abnormal_olfaction1.74554679
32MP0002557_abnormal_social/conspecific_i1.74206399
33MP0005646_abnormal_pituitary_gland1.72333620
34MP0000778_abnormal_nervous_system1.72270620
35MP0004811_abnormal_neuron_physiology1.62766756
36MP0003329_amyloid_beta_deposits1.57574135
37MP0004142_abnormal_muscle_tone1.55946130
38MP0003787_abnormal_imprinting1.54561688
39MP0005645_abnormal_hypothalamus_physiol1.53458087
40MP0008569_lethality_at_weaning1.49848342
41MP0001188_hyperpigmentation1.46272475
42MP0000955_abnormal_spinal_cord1.46138281
43MP0009780_abnormal_chondrocyte_physiolo1.45472689
44MP0002909_abnormal_adrenal_gland1.43525263
45MP0003879_abnormal_hair_cell1.39486502
46MP0002066_abnormal_motor_capabilities/c1.36945745
47MP0002882_abnormal_neuron_morphology1.36176737
48MP0002837_dystrophic_cardiac_calcinosis1.33713766
49MP0010386_abnormal_urinary_bladder1.24933577
50MP0008872_abnormal_physiological_respon1.24188297
51MP0001502_abnormal_circadian_rhythm1.20605734
52MP0000751_myopathy1.16017937
53MP0000920_abnormal_myelination1.15680722
54MP0002876_abnormal_thyroid_physiology1.14279880
55MP0003690_abnormal_glial_cell1.11096584
56MP0003633_abnormal_nervous_system1.06836528
57MP0002152_abnormal_brain_morphology0.99955615
58MP0003631_nervous_system_phenotype0.97343730
59MP0002638_abnormal_pupillary_reflex0.94550165
60MP0002069_abnormal_eating/drinking_beha0.94341438
61MP0005535_abnormal_body_temperature0.94328666
62MP0002229_neurodegeneration0.94053410
63MP0005394_taste/olfaction_phenotype0.93274201
64MP0005499_abnormal_olfactory_system0.93274201
65MP0005551_abnormal_eye_electrophysiolog0.90108259
66MP0004147_increased_porphyrin_level0.89596716
67MP0001986_abnormal_taste_sensitivity0.86494092
68MP0008874_decreased_physiological_sensi0.84683081
69MP0000631_abnormal_neuroendocrine_gland0.84334573
70MP0000013_abnormal_adipose_tissue0.83989877
71MP0001664_abnormal_digestion0.83688562
72MP0002751_abnormal_autonomic_nervous0.82898499
73MP0004742_abnormal_vestibular_system0.82666665
74MP0002752_abnormal_somatic_nervous0.81444822
75MP0001963_abnormal_hearing_physiology0.80916302
76MP0004085_abnormal_heartbeat0.79185057
77MP0004885_abnormal_endolymph0.77465427
78MP0003861_abnormal_nervous_system0.76012909
79MP0003121_genomic_imprinting0.71000625
80MP0003634_abnormal_glial_cell0.70282928
81MP0003632_abnormal_nervous_system0.68691533
82MP0005623_abnormal_meninges_morphology0.67697778
83MP0001177_atelectasis0.66108944
84MP0002090_abnormal_vision0.66108723
85MP0001485_abnormal_pinna_reflex0.65198229
86MP0000604_amyloidosis0.65093512
87MP0004145_abnormal_muscle_electrophysio0.63313303
88MP0004215_abnormal_myocardial_fiber0.61900235
89MP0001943_abnormal_respiration0.60535122
90MP0001348_abnormal_lacrimal_gland0.60264138
91MP0004484_altered_response_of0.60045624
92MP0010768_mortality/aging0.59687300
93MP0003123_paternal_imprinting0.59663181
94MP0005409_darkened_coat_color0.59055333
95MP0000579_abnormal_nail_morphology0.58294528
96MP0006035_abnormal_mitochondrial_morpho0.58023139
97MP0003137_abnormal_impulse_conducting0.57731017
98MP0002332_abnormal_exercise_endurance0.55553399
99MP0003646_muscle_fatigue0.54367702
100MP0000569_abnormal_digit_pigmentation0.54061605
101MP0006072_abnormal_retinal_apoptosis0.53952640
102MP0008877_abnormal_DNA_methylation0.52104602
103MP0005167_abnormal_blood-brain_barrier0.52038215
104MP0004233_abnormal_muscle_weight0.51977799
105MP0002873_normal_phenotype0.51496938
106MP0003938_abnormal_ear_development0.50783300
107MP0002169_no_abnormal_phenotype0.50390783
108MP0003183_abnormal_peptide_metabolism0.50139917
109MP0000538_abnormal_urinary_bladder0.49777230
110MP0002082_postnatal_lethality0.48817082
111MP0010770_preweaning_lethality0.48817082
112MP0000026_abnormal_inner_ear0.48597927
113MP0000566_synostosis0.48269284
114MP0003956_abnormal_body_size0.48174127
115MP0001346_abnormal_lacrimal_gland0.48173654
116MP0010769_abnormal_survival0.47510650
117MP0002081_perinatal_lethality0.46632046
118MP0002653_abnormal_ependyma_morphology0.46097948

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.41893750
2Myokymia (HP:0002411)6.32699163
3Focal seizures (HP:0007359)5.43225525
4Atonic seizures (HP:0010819)5.15705849
5Visual hallucinations (HP:0002367)5.03321532
6Epileptic encephalopathy (HP:0200134)4.67684096
7Febrile seizures (HP:0002373)4.63786878
8Limb dystonia (HP:0002451)4.43837090
9Absence seizures (HP:0002121)4.27293788
10Progressive cerebellar ataxia (HP:0002073)4.15916677
11Dialeptic seizures (HP:0011146)3.91355275
12Generalized tonic-clonic seizures (HP:0002069)3.81332939
13Pheochromocytoma (HP:0002666)3.56564670
14Cerebral hypomyelination (HP:0006808)3.50908851
15Hyperventilation (HP:0002883)3.32600130
16Neuroendocrine neoplasm (HP:0100634)3.26382745
17Polyphagia (HP:0002591)3.22399788
18Failure to thrive in infancy (HP:0001531)3.17915899
19Abnormal eating behavior (HP:0100738)3.16320426
20Broad-based gait (HP:0002136)3.10565499
21Amblyopia (HP:0000646)3.06308820
22Supranuclear gaze palsy (HP:0000605)3.04347741
23Action tremor (HP:0002345)3.02547704
24Ankle clonus (HP:0011448)3.00911018
25Impaired vibration sensation in the lower limbs (HP:0002166)3.00885240
26Progressive inability to walk (HP:0002505)2.99791965
27Abnormal hair whorl (HP:0010721)2.97627428
28Anxiety (HP:0000739)2.91890091
29Morphological abnormality of the pyramidal tract (HP:0002062)2.85846199
30Intention tremor (HP:0002080)2.85307149
31Depression (HP:0000716)2.82888077
32Peripheral hypomyelination (HP:0007182)2.80465923
33Truncal ataxia (HP:0002078)2.79842315
34Gaze-evoked nystagmus (HP:0000640)2.77585881
35Hypothermia (HP:0002045)2.76531088
36Annular pancreas (HP:0001734)2.75632052
37Neuronal loss in central nervous system (HP:0002529)2.74024213
38Gait imbalance (HP:0002141)2.68974220
39Poor eye contact (HP:0000817)2.66724347
40Mutism (HP:0002300)2.66427328
41Tetraplegia (HP:0002445)2.62984970
42Urinary bladder sphincter dysfunction (HP:0002839)2.62520831
43Termporal pattern (HP:0011008)2.62448139
44Insidious onset (HP:0003587)2.62448139
45Dysdiadochokinesis (HP:0002075)2.61402977
46Rigidity (HP:0002063)2.57964927
47Poor suck (HP:0002033)2.57063720
48Acute necrotizing encephalopathy (HP:0006965)2.54831070
49Hypoventilation (HP:0002791)2.54458712
50Epileptiform EEG discharges (HP:0011182)2.53344963
51Dysmetria (HP:0001310)2.49375165
52Abnormality of the corticospinal tract (HP:0002492)2.47767162
53Abnormal social behavior (HP:0012433)2.45923136
54Impaired social interactions (HP:0000735)2.45923136
55Hemiplegia (HP:0002301)2.42667620
56Abnormal mitochondria in muscle tissue (HP:0008316)2.42334894
57Urinary urgency (HP:0000012)2.41426283
58Excessive salivation (HP:0003781)2.40944742
59Drooling (HP:0002307)2.40944742
60CNS hypomyelination (HP:0003429)2.40844809
61Fetal akinesia sequence (HP:0001989)2.39474334
62EEG with generalized epileptiform discharges (HP:0011198)2.38718247
63Apathy (HP:0000741)2.38538222
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.38048888
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38048888
66Bradykinesia (HP:0002067)2.38004997
67Inability to walk (HP:0002540)2.36982904
68Abnormality of binocular vision (HP:0011514)2.36390434
69Diplopia (HP:0000651)2.36390434
70Progressive macrocephaly (HP:0004481)2.35421733
71Insomnia (HP:0100785)2.35250618
72Spastic gait (HP:0002064)2.34712051
73Diminished movement (HP:0002374)2.28989811
74Cerebral inclusion bodies (HP:0100314)2.28804033
75Torticollis (HP:0000473)2.27237668
76Congenital primary aphakia (HP:0007707)2.25595838
77Delusions (HP:0000746)2.24724162
78Diminished motivation (HP:0000745)2.23810722
79Hypsarrhythmia (HP:0002521)2.23614552
80Focal dystonia (HP:0004373)2.21609215
81Medial flaring of the eyebrow (HP:0010747)2.18616443
82Akinesia (HP:0002304)2.17654087
83Specific learning disability (HP:0001328)2.17638127
84Abnormality of the lower motor neuron (HP:0002366)2.17289905
85Abnormality of pain sensation (HP:0010832)2.17066612
86Impaired pain sensation (HP:0007328)2.17066612
87Obstructive sleep apnea (HP:0002870)2.16461813
88Ventricular fibrillation (HP:0001663)2.13015702
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12386663
90Clonus (HP:0002169)2.11881840
91Spastic tetraparesis (HP:0001285)2.11537898
92Scanning speech (HP:0002168)2.11348930
93Postural instability (HP:0002172)2.10946162
94Rapidly progressive (HP:0003678)2.10505258
95Neoplasm of the peripheral nervous system (HP:0100007)2.10034995
96Abnormality of ocular smooth pursuit (HP:0000617)2.09234546
97Esotropia (HP:0000565)2.09136375
98Nephrogenic diabetes insipidus (HP:0009806)2.08144885
99Genital tract atresia (HP:0001827)2.08094873
100Craniofacial dystonia (HP:0012179)2.06682154
101Hemiparesis (HP:0001269)2.06018745
102Agitation (HP:0000713)2.05206417
103Hyperthyroidism (HP:0000836)2.04477429
104Choreoathetosis (HP:0001266)2.04272874
105Oligomenorrhea (HP:0000876)2.04157999
106Mitochondrial inheritance (HP:0001427)2.01953006
107Abnormality of the labia minora (HP:0012880)2.01905470
108Lower limb muscle weakness (HP:0007340)2.01092866
109Vaginal atresia (HP:0000148)2.00959690
110Neurofibrillary tangles (HP:0002185)1.99352795
111Spastic tetraplegia (HP:0002510)1.99228021
112Genetic anticipation (HP:0003743)1.98368533
113Psychosis (HP:0000709)1.98022677
114Stereotypic behavior (HP:0000733)1.97851111
115Absent speech (HP:0001344)1.95736243
116Muscular hypotonia of the trunk (HP:0008936)1.94897038
117Hypokinesia (HP:0002375)1.94325444
118Abnormality of saccadic eye movements (HP:0000570)1.94251516
119Impaired smooth pursuit (HP:0007772)1.93954567
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92527374
121Generalized myoclonic seizures (HP:0002123)1.91801244
122Impaired vibratory sensation (HP:0002495)1.91107597
123Resting tremor (HP:0002322)1.88874082
124Sleep apnea (HP:0010535)1.88169896
125Papilledema (HP:0001085)1.88064023
126Incomplete penetrance (HP:0003829)1.87873305
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87703693
128Hypoplasia of the brainstem (HP:0002365)1.87703693
129Narrow nasal bridge (HP:0000446)1.86768092
130Status epilepticus (HP:0002133)1.86612711
131Dyskinesia (HP:0100660)1.85074963
132Amyotrophic lateral sclerosis (HP:0007354)1.78298831
133Aplasia involving bones of the extremities (HP:0009825)1.74976722
134Aplasia involving bones of the upper limbs (HP:0009823)1.74976722
135Aplasia of the phalanges of the hand (HP:0009802)1.74976722
136Gait ataxia (HP:0002066)1.72786880
137Neonatal onset (HP:0003623)1.72664453
138Megalencephaly (HP:0001355)1.72520589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.07275320
2CASK3.62995403
3MAP3K123.56577715
4MAP3K93.47961163
5MAP3K43.43634600
6MAP2K73.14930870
7MARK13.14408719
8EPHA43.02976193
9MINK12.68072025
10MAP2K42.22133210
11GRK52.09433235
12DAPK22.04785383
13NTRK11.97925930
14NTRK21.94997663
15PLK21.94234564
16ARAF1.91348183
17PNCK1.78584752
18KSR21.73140000
19DAPK11.62903823
20RIPK41.62818278
21PAK61.59790464
22MAPK131.58138196
23CDK191.52106472
24CDK51.41036801
25KSR11.30479512
26PRKCG1.29870938
27MAP3K111.19688363
28NME11.15824535
29CAMK2A1.14714880
30TNIK1.10840764
31CSNK1G21.09321731
32GRK71.08425118
33PHKG11.06831352
34PHKG21.06831352
35PRPF4B1.05717873
36LATS21.02726543
37UHMK11.02327995
38SIK21.00331904
39CAMKK11.00122486
40AKT31.00102545
41SGK2230.97560685
42SGK4940.97560685
43CDK180.96946488
44ALK0.96929019
45FES0.96169937
46CDK140.95614363
47OXSR10.94638327
48CAMK2B0.93149578
49CDK150.92325973
50TSSK60.86263188
51SGK20.84674787
52BRSK10.82532488
53MAP3K130.80653895
54PTK2B0.80193872
55CDK11A0.79660481
56CAMKK20.79217630
57MAP3K20.78773002
58CSNK1G30.77507306
59PKN10.75232826
60RET0.74707866
61SIK30.74249729
62BRAF0.74161178
63MAPK120.73734824
64ADRBK20.73375357
65PRKD30.73131832
66MAPKAPK50.72384394
67PRKCE0.70325270
68STK380.66956388
69DYRK1A0.66736558
70ADRBK10.65305222
71PAK30.64100085
72CCNB10.64024785
73BMPR20.63087725
74NEK60.59618497
75CAMK2G0.59124164
76CAMK2D0.58913506
77RAF10.58095075
78CAMK10.57881901
79LMTK20.57181571
80LIMK10.57109525
81STK110.56872510
82RIPK10.56669194
83FER0.56607455
84MAP2K10.56572182
85MAPK100.56322283
86PDK30.55043284
87PDK40.55043284
88FGR0.54384312
89CAMK40.53802056
90RPS6KA30.53401388
91CAMK1G0.52704988
92PRKCH0.52214778
93TNK20.51960088
94BCR0.50595268
95SGK10.50574196
96WNK30.49355244
97SGK30.48193306
98MAP3K10.47879227
99TYRO30.47827589
100RPS6KA20.47761237
101NEK10.46052208
102TESK10.44338889
103PDK10.44165053
104PRKCZ0.42842052
105MARK20.40581085
106ROCK20.40109840
107DAPK30.39890374
108PINK10.39794636
109MAP3K60.39218503
110CSNK1E0.38877422
111CSNK1G10.38418798
112PRKG20.36932882
113GRK60.36373289
114DYRK20.36367725
115PRKACA0.36203749
116PRKCA0.33765509
117DMPK0.33361352
118MAPK80.32726015
119FYN0.31523748
120CAMK1D0.31302079
121CSNK1D0.29136566
122PDPK10.27335929
123PRKG10.26776745
124GSK3B0.26087314
125CSNK1A10.24422837
126CSNK1A1L0.23618348
127PRKCB0.23123334

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.10669398
2Nicotine addiction_Homo sapiens_hsa050334.03245060
3Collecting duct acid secretion_Homo sapiens_hsa049662.88240142
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72853423
5GABAergic synapse_Homo sapiens_hsa047272.67822752
6Olfactory transduction_Homo sapiens_hsa047402.57974694
7Amphetamine addiction_Homo sapiens_hsa050312.49170629
8Circadian entrainment_Homo sapiens_hsa047132.45564302
9Morphine addiction_Homo sapiens_hsa050322.43278289
10Long-term potentiation_Homo sapiens_hsa047202.36795840
11Dopaminergic synapse_Homo sapiens_hsa047282.29769984
12Glutamatergic synapse_Homo sapiens_hsa047242.27148911
13Oxidative phosphorylation_Homo sapiens_hsa001902.10502279
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10334395
15Taste transduction_Homo sapiens_hsa047421.98250401
16Cocaine addiction_Homo sapiens_hsa050301.93631453
17Serotonergic synapse_Homo sapiens_hsa047261.92684673
18Salivary secretion_Homo sapiens_hsa049701.92102704
19Insulin secretion_Homo sapiens_hsa049111.85328138
20Cholinergic synapse_Homo sapiens_hsa047251.83403517
21Vibrio cholerae infection_Homo sapiens_hsa051101.82298629
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78539047
23Parkinsons disease_Homo sapiens_hsa050121.71367007
24Long-term depression_Homo sapiens_hsa047301.67447013
25Renin secretion_Homo sapiens_hsa049241.63406034
26Gastric acid secretion_Homo sapiens_hsa049711.60123832
27Vitamin B6 metabolism_Homo sapiens_hsa007501.54863113
28Calcium signaling pathway_Homo sapiens_hsa040201.49980466
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48485319
30Alzheimers disease_Homo sapiens_hsa050101.47259531
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42082793
32Cardiac muscle contraction_Homo sapiens_hsa042601.41134840
33Oxytocin signaling pathway_Homo sapiens_hsa049211.37570356
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36510248
35Gap junction_Homo sapiens_hsa045401.29789389
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28743676
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26706960
38GnRH signaling pathway_Homo sapiens_hsa049121.25389454
39Huntingtons disease_Homo sapiens_hsa050161.08496861
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06935997
41Phototransduction_Homo sapiens_hsa047441.00955052
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00884044
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99332650
44Estrogen signaling pathway_Homo sapiens_hsa049150.98481153
45Axon guidance_Homo sapiens_hsa043600.97502311
46cAMP signaling pathway_Homo sapiens_hsa040240.96989427
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96457541
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90570398
49Melanogenesis_Homo sapiens_hsa049160.86073179
50ErbB signaling pathway_Homo sapiens_hsa040120.82991773
51Type II diabetes mellitus_Homo sapiens_hsa049300.81907974
52Glioma_Homo sapiens_hsa052140.78813808
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78683331
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.77777392
55Oocyte meiosis_Homo sapiens_hsa041140.77339079
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77038772
57Rheumatoid arthritis_Homo sapiens_hsa053230.76567126
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65633500
59Alcoholism_Homo sapiens_hsa050340.63283061
60Thyroid hormone synthesis_Homo sapiens_hsa049180.61958803
61Pancreatic secretion_Homo sapiens_hsa049720.60218255
62Phagosome_Homo sapiens_hsa041450.58693570
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57953777
64Type I diabetes mellitus_Homo sapiens_hsa049400.56891244
65Dorso-ventral axis formation_Homo sapiens_hsa043200.56452741
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55334135
67MAPK signaling pathway_Homo sapiens_hsa040100.53934704
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53435785
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53051774
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.50018353
71Dilated cardiomyopathy_Homo sapiens_hsa054140.49915947
72Glucagon signaling pathway_Homo sapiens_hsa049220.49072798
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47704753
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47096933
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46505822
76Choline metabolism in cancer_Homo sapiens_hsa052310.43619767
77Ras signaling pathway_Homo sapiens_hsa040140.42933702
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42900632
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.42297766
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42132055
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39978915
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39082679
83Arginine biosynthesis_Homo sapiens_hsa002200.38702282
84Arginine and proline metabolism_Homo sapiens_hsa003300.37223718
85Inositol phosphate metabolism_Homo sapiens_hsa005620.35083103
86Prion diseases_Homo sapiens_hsa050200.34356244
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33815032
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.32949091
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32674553
90African trypanosomiasis_Homo sapiens_hsa051430.31424357
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31324270
92Rap1 signaling pathway_Homo sapiens_hsa040150.30957204
93Insulin signaling pathway_Homo sapiens_hsa049100.30945667
94Pyruvate metabolism_Homo sapiens_hsa006200.30234694
95Butanoate metabolism_Homo sapiens_hsa006500.30171092
96Endocytosis_Homo sapiens_hsa041440.29233823
97Hippo signaling pathway_Homo sapiens_hsa043900.28348524
98Regulation of autophagy_Homo sapiens_hsa041400.26910571
99AMPK signaling pathway_Homo sapiens_hsa041520.26735032
100VEGF signaling pathway_Homo sapiens_hsa043700.25676400
101Ovarian steroidogenesis_Homo sapiens_hsa049130.24467661
102Circadian rhythm_Homo sapiens_hsa047100.23725293
103Wnt signaling pathway_Homo sapiens_hsa043100.23496685
104mTOR signaling pathway_Homo sapiens_hsa041500.23082492
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22924999
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22920330
107Bile secretion_Homo sapiens_hsa049760.22845815
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.22845710
109Renal cell carcinoma_Homo sapiens_hsa052110.21911597
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21713288
111Tight junction_Homo sapiens_hsa045300.19721052
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19606893
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17304300
114Folate biosynthesis_Homo sapiens_hsa007900.16918776
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15256700

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