SYNGR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein. The gene belongs to the synaptogyrin gene family. Like other members of the family the protein contains four transmembrane regions. The exact function of this protein is unclear. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.98350385
2cell wall macromolecule metabolic process (GO:0044036)9.98350385
3binding of sperm to zona pellucida (GO:0007339)9.89058806
4axonemal dynein complex assembly (GO:0070286)9.85296924
5multicellular organism reproduction (GO:0032504)9.51934917
6cell-cell recognition (GO:0009988)9.47671916
7spermatid development (GO:0007286)9.29819145
8motile cilium assembly (GO:0044458)9.24563288
9epithelial cilium movement (GO:0003351)8.94074512
10plasma membrane fusion (GO:0045026)8.92250557
11male meiosis (GO:0007140)8.55559718
12synaptonemal complex organization (GO:0070193)8.39133261
13synaptonemal complex assembly (GO:0007130)8.16075153
14reproduction (GO:0000003)8.03199364
15regulation of cilium movement (GO:0003352)7.97925958
16cilium movement (GO:0003341)7.41702170
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.36941125
18negative regulation of inclusion body assembly (GO:0090084)6.76443505
19single fertilization (GO:0007338)6.63835609
20DNA methylation involved in gamete generation (GO:0043046)6.59881638
21spermatogenesis (GO:0007283)6.42797222
22male gamete generation (GO:0048232)6.40859304
23sperm capacitation (GO:0048240)6.33998927
24male meiosis I (GO:0007141)6.23845952
25microtubule depolymerization (GO:0007019)6.15436848
26fertilization (GO:0009566)5.97587379
27gamete generation (GO:0007276)5.90421997
28chromosome organization involved in meiosis (GO:0070192)5.83963345
29organic cation transport (GO:0015695)5.59428338
30regulation of type B pancreatic cell apoptotic process (GO:2000674)5.55088141
31meiotic nuclear division (GO:0007126)5.54258940
32regulation of inclusion body assembly (GO:0090083)5.50375140
33germ cell development (GO:0007281)5.46260073
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.29198922
35lactate metabolic process (GO:0006089)5.18977534
36meiosis I (GO:0007127)5.15722407
37chromosome condensation (GO:0030261)5.08057849
38regulation of glucokinase activity (GO:0033131)4.96987004
39regulation of hexokinase activity (GO:1903299)4.96987004
40DNA packaging (GO:0006323)4.92256979
41endocrine pancreas development (GO:0031018)4.86360618
42meiotic cell cycle (GO:0051321)4.80879631
43seminiferous tubule development (GO:0072520)4.77295515
44ventricular system development (GO:0021591)4.73933779
45insulin secretion (GO:0030073)4.68519721
46regulation of microtubule-based movement (GO:0060632)4.68151145
47inositol phosphate catabolic process (GO:0071545)4.63892819
48calcium ion-dependent exocytosis (GO:0017156)4.63137106
49multicellular organismal reproductive process (GO:0048609)4.61750528
50positive regulation of glycolytic process (GO:0045821)4.52453258
51cellular ketone body metabolic process (GO:0046950)4.49058407
52positive regulation of insulin secretion (GO:0032024)4.47844588
53microtubule severing (GO:0051013)4.41508020
54cell recognition (GO:0008037)4.40120748
55phosphorylated carbohydrate dephosphorylation (GO:0046838)4.32685251
56inositol phosphate dephosphorylation (GO:0046855)4.32685251
57left/right pattern formation (GO:0060972)4.25842951
58chaperone-mediated protein complex assembly (GO:0051131)4.08892010
59spermatid nucleus differentiation (GO:0007289)4.03160394
60positive regulation of peptide hormone secretion (GO:0090277)4.01493596
61respiratory chain complex IV assembly (GO:0008535)3.99955408
62gene silencing by RNA (GO:0031047)3.99344847
63ketone body metabolic process (GO:1902224)3.94099344
64glycerol ether metabolic process (GO:0006662)3.93786360
65regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.86166873
66positive regulation of peptide secretion (GO:0002793)3.85580613
67peptide hormone processing (GO:0016486)3.84390526
68negative regulation of protein oligomerization (GO:0032460)3.83921876
69positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.81759340
70cytochrome complex assembly (GO:0017004)3.81252834
71meiotic cell cycle process (GO:1903046)3.76408619
72L-alpha-amino acid transmembrane transport (GO:1902475)3.74331759
73glandular epithelial cell differentiation (GO:0002067)3.74330676
74water-soluble vitamin biosynthetic process (GO:0042364)3.72368425
75regulation of spindle checkpoint (GO:0090231)3.70489993
76epithelial cell fate commitment (GO:0072148)3.70460733
77multicellular organismal development (GO:0007275)3.69772345
78nitric oxide mediated signal transduction (GO:0007263)3.68043725
79negative regulation of execution phase of apoptosis (GO:1900118)3.63647746
80ether metabolic process (GO:0018904)3.62391856
81protein localization to cilium (GO:0061512)3.61436017
82negative regulation of hormone biosynthetic process (GO:0032353)3.60645895
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.59251154
84genitalia morphogenesis (GO:0035112)3.55157695
85protein polyglutamylation (GO:0018095)3.53207700
86regulation of meiosis I (GO:0060631)3.51179728
87regulation of insulin secretion (GO:0050796)3.50671599
88single strand break repair (GO:0000012)3.50514868
89positive regulation of meiosis (GO:0045836)3.50189882
90synapsis (GO:0007129)3.49539347
91detection of calcium ion (GO:0005513)3.48282135
92mitotic sister chromatid cohesion (GO:0007064)3.39925817
93monoubiquitinated protein deubiquitination (GO:0035520)3.38521395
94polyol catabolic process (GO:0046174)3.37076460
95glycerophospholipid catabolic process (GO:0046475)3.36964204
96regulation of energy homeostasis (GO:2000505)3.35359646
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32777182
98positive regulation of meiotic cell cycle (GO:0051446)3.23557179
99regulation of peptide hormone secretion (GO:0090276)3.21110380
100microtubule polymerization or depolymerization (GO:0031109)3.19297247
101macroautophagy (GO:0016236)3.18883728
102nucleus organization (GO:0006997)3.18803182
103positive regulation of gluconeogenesis (GO:0045722)3.17802264
104carnitine transport (GO:0015879)3.16087897
105amino-acid betaine transport (GO:0015838)3.16087897
106gene silencing (GO:0016458)3.15803285
107protein refolding (GO:0042026)3.14539885
108regulation of peptide secretion (GO:0002791)3.13260819
109negative regulation of organelle assembly (GO:1902116)3.12927056
110COPII vesicle coating (GO:0048208)3.12801803
111nuclear pore complex assembly (GO:0051292)3.12226489
112zinc ion homeostasis (GO:0055069)3.09680445
113carnitine transmembrane transport (GO:1902603)3.09549516
114peptide hormone secretion (GO:0030072)3.09377367
115negative regulation of hormone metabolic process (GO:0032351)3.08297592
116nitric oxide biosynthetic process (GO:0006809)3.07893139
117positive regulation of calcium ion import (GO:0090280)3.05140560
118signal peptide processing (GO:0006465)3.02419580
119intraciliary transport (GO:0042073)3.01924431
120protein complex biogenesis (GO:0070271)3.00749802
121protein localization to chromosome, centromeric region (GO:0071459)2.99082705
122chemosensory behavior (GO:0007635)2.98926128
123fatty acid homeostasis (GO:0055089)2.97642039
124peptide secretion (GO:0002790)2.97231634
125positive regulation of hormone secretion (GO:0046887)2.95843519
126negative regulation of gluconeogenesis (GO:0045721)2.90865846
127DNA replication-dependent nucleosome organization (GO:0034723)2.90862526
128DNA replication-dependent nucleosome assembly (GO:0006335)2.90862526
129regulation of centriole replication (GO:0046599)2.89922211
130axoneme assembly (GO:0035082)2.86752349
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85543581
132L-phenylalanine catabolic process (GO:0006559)2.85543581
133potassium ion export (GO:0071435)2.84523829
134regulation of hormone secretion (GO:0046883)2.83466299
135sexual reproduction (GO:0019953)2.82624930
136interferon-gamma secretion (GO:0072643)2.81921363
137glycolytic process (GO:0006096)2.81794016
138sequestering of actin monomers (GO:0042989)2.81642610
139microtubule-based movement (GO:0007018)2.80539015
140regulation of histone H3-K9 methylation (GO:0051570)2.79270771
141response to glucose (GO:0009749)2.74767204
142pteridine-containing compound biosynthetic process (GO:0042559)2.73774038
143protein targeting to Golgi (GO:0000042)2.73067678
144regulation of oxidative phosphorylation (GO:0002082)2.72794966
145histone exchange (GO:0043486)2.72374369
146intestinal cholesterol absorption (GO:0030299)2.71087263
147DNA alkylation (GO:0006305)2.70884783
148DNA methylation (GO:0006306)2.70884783
149positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69557276
150L-phenylalanine metabolic process (GO:0006558)2.69504178
151erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69504178
152protein K11-linked deubiquitination (GO:0035871)2.68364501
153xenobiotic catabolic process (GO:0042178)2.68309870
154cilium organization (GO:0044782)2.68274915
155establishment of protein localization to Golgi (GO:0072600)2.67527234
156protein localization to Golgi apparatus (GO:0034067)2.67332578
157nodal signaling pathway (GO:0038092)2.67026887
158neuron fate specification (GO:0048665)2.66904799
159positive regulation of histone H3-K4 methylation (GO:0051571)2.66599407
160regulation of acrosome reaction (GO:0060046)2.66441958
161brain morphogenesis (GO:0048854)2.65182791
162C-terminal protein lipidation (GO:0006501)2.64871253
163sister chromatid cohesion (GO:0007062)2.64394801
164positive regulation of protein autophosphorylation (GO:0031954)2.63764344
165sex differentiation (GO:0007548)2.63387964
166preassembly of GPI anchor in ER membrane (GO:0016254)2.63282740
167RNA localization (GO:0006403)2.62231632
168platelet dense granule organization (GO:0060155)2.62006248
169intra-Golgi vesicle-mediated transport (GO:0006891)2.61625636
170alditol metabolic process (GO:0019400)2.61416294
171nuclear pore organization (GO:0006999)2.61180818
172auditory receptor cell differentiation (GO:0042491)2.60896995
173cilium morphogenesis (GO:0060271)2.60822955
174C-terminal protein amino acid modification (GO:0018410)2.60110482
175response to hexose (GO:0009746)2.59577673
176keratinocyte development (GO:0003334)2.59564943
177phenylpropanoid metabolic process (GO:0009698)2.58933746
178mitochondrial respiratory chain complex assembly (GO:0033108)2.58387233
179mannosylation (GO:0097502)2.58315998
180protein maturation by protein folding (GO:0022417)2.57708091
181toxin transport (GO:1901998)2.56794397
182regulation of mitochondrial translation (GO:0070129)2.56645262
183adaptation of signaling pathway (GO:0023058)2.53999608
184sperm motility (GO:0030317)12.2823139
185fusion of sperm to egg plasma membrane (GO:0007342)11.8309495
186acrosome reaction (GO:0007340)10.9313744
187cilium or flagellum-dependent cell motility (GO:0001539)10.8486326
188sperm-egg recognition (GO:0035036)10.6007958
189piRNA metabolic process (GO:0034587)10.2708098
190acrosome assembly (GO:0001675)10.1577083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.57569896
2EZH2_22144423_ChIP-Seq_EOC_Human4.10511968
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.52465771
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.10898864
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.04047230
6CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.79383869
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61739035
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55155184
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46578940
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.42275935
11GBX2_23144817_ChIP-Seq_PC3_Human2.30395897
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25409877
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20890659
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11899939
15VDR_22108803_ChIP-Seq_LS180_Human2.11028031
16* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2883070
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98355813
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.96236732
19IGF1R_20145208_ChIP-Seq_DFB_Human1.96192938
20HTT_18923047_ChIP-ChIP_STHdh_Human1.94954987
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89700581
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87920445
23FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87093872
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85527924
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.84012974
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78175925
27BCAT_22108803_ChIP-Seq_LS180_Human1.76194400
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75907027
29FUS_26573619_Chip-Seq_HEK293_Human1.70929491
30ZNF274_21170338_ChIP-Seq_K562_Hela1.69841851
31TP53_22573176_ChIP-Seq_HFKS_Human1.66160975
32STAT1_17558387_ChIP-Seq_HELA_Human1.63005459
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62016075
34SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61613685
35P300_19829295_ChIP-Seq_ESCs_Human1.60082942
36GATA3_21867929_ChIP-Seq_CD8_Mouse1.59640599
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57558820
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57346820
39FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57065305
40SMAD4_21799915_ChIP-Seq_A2780_Human1.54031839
41ER_23166858_ChIP-Seq_MCF-7_Human1.51047253
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.49919426
43AR_25329375_ChIP-Seq_VCAP_Human1.49719119
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.47001334
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47001334
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46271711
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45066660
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.44953962
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43387069
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.42516472
51STAT3_23295773_ChIP-Seq_U87_Human1.42418107
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41415179
53KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40464709
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40286890
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.37712070
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37421805
57TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.36658865
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36078858
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35440505
60SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34739266
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34237951
62TAF15_26573619_Chip-Seq_HEK293_Human1.34158315
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.33070208
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.32768898
65TCF4_23295773_ChIP-Seq_U87_Human1.28483222
66* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28027918
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27898063
68P53_21459846_ChIP-Seq_SAOS-2_Human1.27700175
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26750056
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26483102
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.26145309
72P53_22387025_ChIP-Seq_ESCs_Mouse1.25689886
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25638030
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24890762
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.24719250
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.24341994
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23303109
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23199322
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.23129124
80SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.22357674
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.22036298
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21963247
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.21291000
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.21279940
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.19312834
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18573700
87AR_20517297_ChIP-Seq_VCAP_Human1.18295428
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.17982703
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.17649737
90EWS_26573619_Chip-Seq_HEK293_Human1.17533995
91* CDX2_22108803_ChIP-Seq_LS180_Human1.17131971
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17001850
93* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16861561
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15963662
95* YY1_22570637_ChIP-Seq_MALME-3M_Human1.15445637
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15435826
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14994917
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14793246
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14172984
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13772717
101NCOR_22424771_ChIP-Seq_293T_Human1.13686702
102RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13679426
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.13362853
104CTCF_18555785_Chip-Seq_ESCs_Mouse1.13308715
105NANOG_19829295_ChIP-Seq_ESCs_Human1.13218660
106SOX2_19829295_ChIP-Seq_ESCs_Human1.13218660
107* SMAD4_21741376_ChIP-Seq_EPCs_Human1.12279777
108EST1_17652178_ChIP-ChIP_JURKAT_Human1.11667652
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11566211
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11476932
111CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11207131
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.10721893
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10480080
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.10389613
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.09797772
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09255734
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09242211
118CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09188909
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.08540706
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07784357
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07040038
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.06840448
123ERG_20517297_ChIP-Seq_VCAP_Human1.05991222
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05906818
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05845464
126LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05408412
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.05251501
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05240110
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05187466
130MYC_19829295_ChIP-Seq_ESCs_Human1.05183653
131RNF2_27304074_Chip-Seq_NSC_Mouse1.04220747
132P300_18555785_Chip-Seq_ESCs_Mouse1.04084098
133CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03902123
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03615245
135KDM2B_26808549_Chip-Seq_REH_Human1.03307214
136TCF4_22108803_ChIP-Seq_LS180_Human1.02734026
137GF1_26923725_Chip-Seq_HPCs_Mouse1.02250505
138CTCF_26484167_Chip-Seq_Bcells_Mouse1.02054919
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01561777
140CBP_20019798_ChIP-Seq_JUKART_Human1.01561777
141PHF8_20622854_ChIP-Seq_HELA_Human1.01510503
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01259762
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01063698
144CTCF_20526341_ChIP-Seq_ESCs_Human1.00744076
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.00499434
146NFE2_27457419_Chip-Seq_LIVER_Mouse1.00278223
147MYC_27129775_Chip-Seq_CORNEA_Mouse1.00212080
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98969458
149BCOR_27268052_Chip-Seq_Bcells_Human0.98961063
150RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98771724
151RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98715645
152RUNX2_22187159_ChIP-Seq_PCA_Human0.98233474
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.97470064
154ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96763305
155GATA3_21878914_ChIP-Seq_MCF-7_Human0.96600792
156FLI1_21867929_ChIP-Seq_CD8_Mouse0.96439125
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96355841
158* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95860364
159RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95587098
160FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94902468
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93899207
162SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93653044
163GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93318376
164BCL6_27268052_Chip-Seq_Bcells_Human0.93023727
165SOX2_21211035_ChIP-Seq_LN229_Human0.93014001
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91588225
167PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90954907
168NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90693435
169PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90159802
170JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89938847
171EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89349720
172RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88953704
173FLI1_21867929_ChIP-Seq_TH2_Mouse0.87777209
174TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87670489
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87670489
176PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87605747
177STAT1_20625510_ChIP-Seq_HELA_Human0.86388932
178RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86371351
179REST_21632747_ChIP-Seq_MESCs_Mouse0.85975445
180E2F1_20622854_ChIP-Seq_HELA_Human0.85281039
181* NANOG_20526341_ChIP-Seq_ESCs_Human0.84361599
182TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79649670
183SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78860487
184NFYB_21822215_ChIP-Seq_K562_Human0.78763771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.84680508
2MP0001929_abnormal_gametogenesis5.60320377
3MP0008877_abnormal_DNA_methylation5.49284991
4MP0002837_dystrophic_cardiac_calcinosis4.28113126
5MP0003195_calcinosis4.24521912
6MP0009780_abnormal_chondrocyte_physiolo4.21245614
7MP0002909_abnormal_adrenal_gland3.98981308
8MP0002210_abnormal_sex_determination3.87943255
9MP0003787_abnormal_imprinting3.71739188
10MP0001145_abnormal_male_reproductive3.28003549
11MP0002161_abnormal_fertility/fecundity3.24812025
12MP0005379_endocrine/exocrine_gland_phen3.11082659
13MP0000013_abnormal_adipose_tissue2.98645546
14MP0000653_abnormal_sex_gland2.84853947
15MP0002163_abnormal_gland_morphology2.81177212
16MP0002693_abnormal_pancreas_physiology2.76055180
17MP0003283_abnormal_digestive_organ2.75880963
18MP0001944_abnormal_pancreas_morphology2.75213281
19MP0002653_abnormal_ependyma_morphology2.66161962
20MP0003122_maternal_imprinting2.58541139
21MP0003123_paternal_imprinting2.53890615
22MP0002876_abnormal_thyroid_physiology2.35546444
23MP0005645_abnormal_hypothalamus_physiol2.28130166
24MP0005670_abnormal_white_adipose2.27965161
25MP0010234_abnormal_vibrissa_follicle2.22113911
26MP0006072_abnormal_retinal_apoptosis2.19385800
27MP0002160_abnormal_reproductive_system2.01096052
28MP0005410_abnormal_fertilization14.9344598
29MP0002254_reproductive_system_inflammat1.96843835
30MP0010094_abnormal_chromosome_stability1.92880660
31MP0005646_abnormal_pituitary_gland1.88536708
32MP0010329_abnormal_lipoprotein_level1.86457521
33MP0002078_abnormal_glucose_homeostasis1.81446926
34MP0008058_abnormal_DNA_repair1.78222883
35MP0003172_abnormal_lysosome_physiology1.72410534
36MP0005332_abnormal_amino_acid1.68279979
37MP0005084_abnormal_gallbladder_morpholo1.65682706
38MP0001756_abnormal_urination1.64123528
39MP0003646_muscle_fatigue1.63457732
40MP0002139_abnormal_hepatobiliary_system1.62353868
41MP0003121_genomic_imprinting1.55031486
42MP0001986_abnormal_taste_sensitivity1.50942315
43MP0004233_abnormal_muscle_weight1.49408535
44MP0008057_abnormal_DNA_replication1.48627565
45MP0005220_abnormal_exocrine_pancreas1.48439687
46MP0003111_abnormal_nucleus_morphology1.47278420
47MP0004019_abnormal_vitamin_homeostasis1.44762652
48MP0004270_analgesia1.36195934
49MP0008995_early_reproductive_senescence1.36177240
50MP0000003_abnormal_adipose_tissue1.33557311
51MP0005448_abnormal_energy_balance1.32053764
52MP0005623_abnormal_meninges_morphology1.29222255
53MP0010386_abnormal_urinary_bladder1.21798215
54MP0009745_abnormal_behavioral_response1.21258239
55MP0003953_abnormal_hormone_level1.20150642
56MP0005367_renal/urinary_system_phenotyp1.17282986
57MP0000516_abnormal_urinary_system1.17282986
58MP0004885_abnormal_endolymph1.16957637
59MP0005551_abnormal_eye_electrophysiolog1.16874962
60MP0002638_abnormal_pupillary_reflex1.15257082
61MP0003786_premature_aging1.14854007
62MP0005535_abnormal_body_temperature1.12376056
63MP0002064_seizures1.07436651
64MP0008007_abnormal_cellular_replicative1.05167037
65MP0002282_abnormal_trachea_morphology1.05043387
66MP0005389_reproductive_system_phenotype1.03263881
67MP0002118_abnormal_lipid_homeostasis0.99837137
68MP0000639_abnormal_adrenal_gland0.99690229
69MP0003077_abnormal_cell_cycle0.98996028
70MP0005397_hematopoietic_system_phenotyp0.98932284
71MP0001545_abnormal_hematopoietic_system0.98932284
72MP0000631_abnormal_neuroendocrine_gland0.98598808
73MP0004043_abnormal_pH_regulation0.97113071
74MP0002557_abnormal_social/conspecific_i0.92790723
75MP0002272_abnormal_nervous_system0.92776870
76MP0005377_hearing/vestibular/ear_phenot0.92558369
77MP0003878_abnormal_ear_physiology0.92558369
78MP0003693_abnormal_embryo_hatching0.92547783
79MP0009278_abnormal_bone_marrow0.92444239
80MP0005647_abnormal_sex_gland0.91228707
81MP0001501_abnormal_sleep_pattern0.85690916
82MP0004924_abnormal_behavior0.85391331
83MP0005386_behavior/neurological_phenoty0.85391331
84MP0002229_neurodegeneration0.83831284
85MP0002090_abnormal_vision0.83630901
86MP0001502_abnormal_circadian_rhythm0.82520623
87MP0000427_abnormal_hair_cycle0.82004064
88MP0001905_abnormal_dopamine_level0.79571049
89MP0001730_embryonic_growth_arrest0.79041350
90MP0004142_abnormal_muscle_tone0.78849830
91MP0009643_abnormal_urine_homeostasis0.78822120
92MP0002572_abnormal_emotion/affect_behav0.77368994
93MP0005365_abnormal_bile_salt0.76915327
94MP0003633_abnormal_nervous_system0.76501906
95MP0001970_abnormal_pain_threshold0.75998189
96MP0000358_abnormal_cell_content/0.75873834
97MP0010307_abnormal_tumor_latency0.75610230
98MP0001984_abnormal_olfaction0.75304912
99MP0005452_abnormal_adipose_tissue0.75245764
100MP0010678_abnormal_skin_adnexa0.74667302
101MP0004808_abnormal_hematopoietic_stem0.74377332
102MP0005075_abnormal_melanosome_morpholog0.73075074
103MP0003115_abnormal_respiratory_system0.72035811
104MP0002938_white_spotting0.71300113
105MP0001765_abnormal_ion_homeostasis0.69613989
106MP0008872_abnormal_physiological_respon0.68822196
107MP0008875_abnormal_xenobiotic_pharmacok0.68775832
108MP0001666_abnormal_nutrient_absorption0.68256569
109MP0002295_abnormal_pulmonary_circulatio0.67722030
110MP0005058_abnormal_lysosome_morphology0.66442315
111MP0001968_abnormal_touch/_nociception0.66067972
112MP0003699_abnormal_female_reproductive0.62814561
113MP0004957_abnormal_blastocyst_morpholog0.62336977
114MP0002269_muscular_atrophy0.58976607
115MP0003011_delayed_dark_adaptation0.58549189
116MP0001119_abnormal_female_reproductive0.57796274
117MP0009046_muscle_twitch0.56354621
118MP0002234_abnormal_pharynx_morphology0.55716939
119MP0000313_abnormal_cell_death0.55389711
120MP0001293_anophthalmia0.51385783
121MP0001697_abnormal_embryo_size0.50277415
122MP0000569_abnormal_digit_pigmentation0.49661904
123MP0008932_abnormal_embryonic_tissue0.48458094
124MP0001672_abnormal_embryogenesis/_devel0.47130044
125MP0005380_embryogenesis_phenotype0.47130044
126MP0002928_abnormal_bile_duct0.45940581
127MP0002084_abnormal_developmental_patter0.45725009
128MP0006036_abnormal_mitochondrial_physio0.43633722
129MP0005636_abnormal_mineral_homeostasis0.42112839
130MP0005666_abnormal_adipose_tissue0.41129901
131MP0001324_abnormal_eye_pigmentation0.40907344
132MP0001764_abnormal_homeostasis0.40892719
133MP0002080_prenatal_lethality0.40467104
134MP0008961_abnormal_basal_metabolism0.37770727
135MP0003984_embryonic_growth_retardation0.37546728
136MP0002085_abnormal_embryonic_tissue0.37380559
137MP0001727_abnormal_embryo_implantation0.37262996
138MP0009115_abnormal_fat_cell0.35324830
139MP0000350_abnormal_cell_proliferation0.35065170
140MP0004133_heterotaxia0.34924332
141MP0002088_abnormal_embryonic_growth/wei0.34847839
142MP0000015_abnormal_ear_pigmentation0.31970330
143MP0004197_abnormal_fetal_growth/weight/0.31471222
144MP0006035_abnormal_mitochondrial_morpho0.31443019
145MP0003942_abnormal_urinary_system0.30538802
146MP0003861_abnormal_nervous_system0.30519493
147MP0000534_abnormal_ureter_morphology0.30289338
148MP0005391_vision/eye_phenotype0.28930770
149MP0003936_abnormal_reproductive_system0.26726828
150MP0003329_amyloid_beta_deposits0.26338539
151MP0002019_abnormal_tumor_incidence0.26270766
152MP0005253_abnormal_eye_physiology0.26157778
153MP0002102_abnormal_ear_morphology0.25496338
154MP0003045_fibrosis0.25249113
155MP0009672_abnormal_birth_weight0.24728996
156MP0005174_abnormal_tail_pigmentation0.24277381
157MP0002405_respiratory_system_inflammati0.23759929
158MP0002132_abnormal_respiratory_system0.23353370
159MP0002092_abnormal_eye_morphology0.23244329
160MP0001849_ear_inflammation0.23015262
161MP0004036_abnormal_muscle_relaxation0.22676018
162MP0002971_abnormal_brown_adipose0.21934353
163MP0001661_extended_life_span0.21893689
164MP0002169_no_abnormal_phenotype0.21577761
165MP0002873_normal_phenotype0.21237742
166MP0003879_abnormal_hair_cell0.20650269
167MP0002086_abnormal_extraembryonic_tissu0.20511457
168MP0008770_decreased_survivor_rate0.17933103
169MP0009703_decreased_birth_body0.17866193
170MP0002152_abnormal_brain_morphology0.17815231
171MP0000703_abnormal_thymus_morphology0.16768713
172MP0002970_abnormal_white_adipose0.16745462
173MP0000001_mammalian_phenotype0.16147158

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.95088609
2Abnormal respiratory motile cilium morphology (HP:0005938)8.91546051
3Abnormal respiratory epithelium morphology (HP:0012253)8.91546051
4Rhinitis (HP:0012384)7.67063634
5Chronic bronchitis (HP:0004469)7.03281604
6Infertility (HP:0000789)6.81344076
7Abnormal ciliary motility (HP:0012262)6.80666261
8Nasal polyposis (HP:0100582)6.55852992
9Hypoglycemic seizures (HP:0002173)6.37945595
10Hyperinsulinemic hypoglycemia (HP:0000825)5.79588519
11Hypoglycemic coma (HP:0001325)5.65704053
12Abnormality of the nasal mucosa (HP:0000433)5.33917806
13Hyperglycemia (HP:0003074)4.95659865
14Ketoacidosis (HP:0001993)4.70456872
15Bronchiectasis (HP:0002110)4.51720693
16Nephronophthisis (HP:0000090)4.51054568
17Bronchitis (HP:0012387)4.44562082
18Male infertility (HP:0003251)4.37829072
19Symptomatic seizures (HP:0011145)4.26991109
20Intestinal atresia (HP:0011100)3.86490335
21Abnormal spermatogenesis (HP:0008669)3.72206943
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.71082895
23Hypothermia (HP:0002045)3.57946490
24Abnormality of endocrine pancreas physiology (HP:0012093)3.56731376
25Abnormality of the pancreatic islet cells (HP:0006476)3.56731376
26Ketosis (HP:0001946)3.50042726
27Large for gestational age (HP:0001520)3.40360029
28Abnormality of the renal medulla (HP:0100957)3.34132518
29Recurrent otitis media (HP:0000403)3.27891583
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23147412
31Hypomagnesemia (HP:0002917)3.20348361
32Late onset (HP:0003584)3.19507503
33Gonadotropin excess (HP:0000837)3.11905440
34Impulsivity (HP:0100710)3.11629314
35EEG with generalized epileptiform discharges (HP:0011198)3.07223044
36Hemiparesis (HP:0001269)3.07155592
37Congenital malformation of the right heart (HP:0011723)3.06789450
38Double outlet right ventricle (HP:0001719)3.06789450
39Insulin-resistant diabetes mellitus (HP:0000831)3.04041754
40Epileptiform EEG discharges (HP:0011182)2.99385786
41Recurrent sinusitis (HP:0011108)2.93472959
42Hypsarrhythmia (HP:0002521)2.93429241
43Abnormality of the lower motor neuron (HP:0002366)2.93159855
44Abnormality of calcium-phosphate metabolism (HP:0100530)2.89880273
45Tubular atrophy (HP:0000092)2.82076952
46Azoospermia (HP:0000027)2.77795646
47Hypokinesia (HP:0002375)2.74874500
48Recurrent bronchitis (HP:0002837)2.72082401
49Tubulointerstitial nephritis (HP:0001970)2.69995143
50Enlarged penis (HP:0000040)2.64718897
51Progressive macrocephaly (HP:0004481)2.64702682
52Abnormality of vitamin B metabolism (HP:0004340)2.62548689
53Molar tooth sign on MRI (HP:0002419)2.62258694
54Abnormality of midbrain morphology (HP:0002418)2.62258694
55Agitation (HP:0000713)2.62144223
56Prominent metopic ridge (HP:0005487)2.54947036
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53671636
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53671636
59Acute necrotizing encephalopathy (HP:0006965)2.44836532
60Increased circulating renin level (HP:0000848)2.41694252
61Abnormality of magnesium homeostasis (HP:0004921)2.39293378
62Tubulointerstitial abnormality (HP:0001969)2.33840822
63Hepatic necrosis (HP:0002605)2.32340414
64Pancreatic islet-cell hyperplasia (HP:0004510)2.31625224
65Medial flaring of the eyebrow (HP:0010747)2.31577445
66Abnormality of the metopic suture (HP:0005556)2.30806335
67Muscular hypotonia of the trunk (HP:0008936)2.30565186
68Abnormality of vitamin metabolism (HP:0100508)2.28774810
69Hyperphosphatemia (HP:0002905)2.28461772
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25073718
71Glycosuria (HP:0003076)2.24225617
72Abnormality of urine glucose concentration (HP:0011016)2.24225617
73Mitochondrial inheritance (HP:0001427)2.22964873
74Abnormal gallbladder physiology (HP:0012438)2.20379219
75Cholecystitis (HP:0001082)2.20379219
76Amyotrophic lateral sclerosis (HP:0007354)2.19696482
77Hyperthyroidism (HP:0000836)2.19262645
78Tongue fasciculations (HP:0001308)2.15976327
79Menstrual irregularities (HP:0000858)2.14716219
80Hypoalbuminemia (HP:0003073)2.14257695
81Abnormal albumin level (HP:0012116)2.14257695
82Progressive inability to walk (HP:0002505)2.13736176
83Proximal tubulopathy (HP:0000114)2.13667002
84Postaxial foot polydactyly (HP:0001830)2.09963988
85Increased CSF lactate (HP:0002490)2.09253194
86Acute encephalopathy (HP:0006846)2.05506625
87Fibular hypoplasia (HP:0003038)2.04344068
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03123280
89Diminished movement (HP:0002374)2.02215409
90Abnormal mitochondria in muscle tissue (HP:0008316)2.01787479
91Aplasia/hypoplasia of the uterus (HP:0008684)2.01554410
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7763346
93Absent/shortened dynein arms (HP:0200106)12.5225598
94Dynein arm defect of respiratory motile cilia (HP:0012255)12.5225598
95Abnormal pancreas size (HP:0012094)1.98925562
96Renal Fanconi syndrome (HP:0001994)1.98425284
97Hyperphosphaturia (HP:0003109)1.97204019
98Testicular neoplasm (HP:0010788)1.95430722
99Spastic tetraparesis (HP:0001285)1.95011789
100Stage 5 chronic kidney disease (HP:0003774)1.94811973
101Gaze-evoked nystagmus (HP:0000640)1.94074235
102Heterotopia (HP:0002282)1.92587868
103Pancreatic cysts (HP:0001737)1.92506892
104Poor suck (HP:0002033)1.91820018
105Short ribs (HP:0000773)1.89257174
106Tubulointerstitial fibrosis (HP:0005576)1.88638113
107Hepatoblastoma (HP:0002884)1.86690591
108Oculomotor apraxia (HP:0000657)1.86508498
109Methylmalonic acidemia (HP:0002912)1.84859535
110Abnormality of the renal cortex (HP:0011035)1.84324026
111Neoplasm of the adrenal cortex (HP:0100641)1.83293969
112Polyphagia (HP:0002591)1.82275731
113Albinism (HP:0001022)1.82083196
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.81744701
115Hypoplasia of the fovea (HP:0007750)1.81744701
116Vacuolated lymphocytes (HP:0001922)1.81741241
117Neuroendocrine neoplasm (HP:0100634)1.77803653
118Congenital hepatic fibrosis (HP:0002612)1.77708893
119Impaired proprioception (HP:0010831)1.76490062
120Type I diabetes mellitus (HP:0100651)1.76246812
121Abnormal biliary tract morphology (HP:0012440)1.76237706
122Anxiety (HP:0000739)1.76122701
123Ventricular fibrillation (HP:0001663)1.75977269
124Absent epiphyses (HP:0010577)1.73937554
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73937554
126Muscle fibrillation (HP:0010546)1.73926035
127Polydipsia (HP:0001959)1.73642501
128Abnormal drinking behavior (HP:0030082)1.73642501
129Testicular atrophy (HP:0000029)1.73615030
130Unilateral renal agenesis (HP:0000122)1.73226562
131Hypobetalipoproteinemia (HP:0003563)1.73044787
132Abnormality of the basal ganglia (HP:0002134)1.72962415
133Renal cortical cysts (HP:0000803)1.70950172
134Tetany (HP:0001281)1.70419688
135Abnormal sex determination (HP:0012244)1.69052011
136Sex reversal (HP:0012245)1.69052011
137Insulin resistance (HP:0000855)1.68865314
138Increased hepatocellular lipid droplets (HP:0006565)1.68702243
139Increased CSF protein (HP:0002922)1.68374796
140Supernumerary spleens (HP:0009799)1.68201950
141Conjunctival hamartoma (HP:0100780)1.67619681
142Vascular calcification (HP:0004934)1.67600381
143Renal dysplasia (HP:0000110)1.66759300
144Abnormality of the anterior horn cell (HP:0006802)1.65434253
145Degeneration of anterior horn cells (HP:0002398)1.65434253
146Dyschromatopsia (HP:0007641)1.65379135
147Facial cleft (HP:0002006)1.61638228
148Bell-shaped thorax (HP:0001591)1.59497810
149Bile duct proliferation (HP:0001408)1.58295554
150Abnormal biliary tract physiology (HP:0012439)1.58295554
151Abnormality of dentin (HP:0010299)1.57956031
152Upper motor neuron abnormality (HP:0002127)1.55935281
153Chronic sinusitis (HP:0011109)1.55491812
154Choroideremia (HP:0001139)1.54842920
155Short thorax (HP:0010306)1.53182352
156Postaxial hand polydactyly (HP:0001162)1.50747953
157Cystic liver disease (HP:0006706)1.50734505
158Microglossia (HP:0000171)1.46174613
159Deformed sella turcica (HP:0002681)1.45567684
160Cerebellar dysplasia (HP:0007033)1.42557719
161Broad distal phalanx of finger (HP:0009836)1.42340740
162Abnormality of renal excretion (HP:0011036)1.39617210
163Renovascular hypertension (HP:0100817)1.36291797
164Absent frontal sinuses (HP:0002688)1.35883837
165Abnormality of the dental root (HP:0006486)1.35051997
166Taurodontia (HP:0000679)1.35051997
167Abnormality of permanent molar morphology (HP:0011071)1.35051997
168Easy fatigability (HP:0003388)1.34160666
169Sensory axonal neuropathy (HP:0003390)1.33876839
170Decreased central vision (HP:0007663)1.33495580
171Sloping forehead (HP:0000340)1.32015891
172Aplasia/Hypoplasia of the fibula (HP:0006492)1.30479766
173Aplasia/Hypoplasia of the lens (HP:0008063)1.29944844
174Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.29390946
175Short femoral neck (HP:0100864)1.29129955
176J-shaped sella turcica (HP:0002680)1.28798487
177Hemorrhage of the eye (HP:0011885)1.27006815
178Median cleft lip (HP:0000161)1.25768316
179Abnormality of molar morphology (HP:0011070)1.23901467
180Abnormality of molar (HP:0011077)1.23901467
181Nephropathy (HP:0000112)1.22593953
182Congenital primary aphakia (HP:0007707)1.21775856
183Aplasia/Hypoplasia of the tongue (HP:0010295)1.21577934
184Abnormality of the dental pulp (HP:0006479)1.20927318
185Abnormal urine output (HP:0012590)1.20053042
186Gait imbalance (HP:0002141)1.18732339
187Abnormality of ocular smooth pursuit (HP:0000617)1.18490407
188Loss of speech (HP:0002371)1.17956945
189Pancreatic fibrosis (HP:0100732)1.17172218
19011 pairs of ribs (HP:0000878)1.16320969
191Decreased electroretinogram (ERG) amplitude (HP:0000654)1.14217335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.99495920
2PDK47.99495920
3FRK7.38520079
4TESK16.02201247
5PDK25.09017038
6PRKD34.75391145
7ICK4.48213372
8MST43.31741195
9PHKG13.08064190
10PHKG23.08064190
11FGFR23.03951357
12NTRK32.44478898
13NEK22.40355775
14DAPK22.29002300
15MAP4K22.22267756
16PTK2B2.15885571
17PAK32.13017020
18WNK42.07007425
19TRPM71.94041765
20GRK11.91425993
21STK391.88342657
22PNCK1.87740060
23ADRBK21.74811874
24MAP3K41.72401263
25STK381.57564314
26FGFR31.52770114
27FER1.49355518
28DYRK1B1.45036871
29INSRR1.38936492
30MAP3K21.38576800
31OXSR11.35175450
32CDC71.34258000
33PRKCE1.30244378
34TNIK1.29203430
35NLK1.27914537
36TTK1.22596909
37PLK21.21972136
38CSNK1G11.20565587
39PRKCI1.17442787
40WNK31.14188075
41MAPKAPK31.05317886
42STK31.05003346
43HIPK21.04594061
44MAPK151.04144992
45PASK1.03669655
46CASK1.02305336
47DYRK31.01687243
48CDK120.99180585
49WNK10.95851068
50CCNB10.95320945
51PRKAA20.94933285
52WEE10.94913410
53ACVR1B0.94332130
54TYRO30.92919765
55PDK10.92090609
56MAPK130.88614434
57STK240.88173551
58CHEK20.85537665
59CAMK2D0.80506556
60CSNK1G30.77846336
61EEF2K0.76316352
62MKNK20.73707147
63ATR0.72829744
64TESK20.72583771
65CSNK1G20.71320560
66UHMK10.71167364
67MAP3K120.69507080
68EPHA30.68523011
69CHEK10.66989072
70TNK20.66288970
71PINK10.66248880
72BCKDK0.64340986
73AKT30.60975300
74PLK10.58745148
75ERBB30.55794507
76MAP2K70.55411078
77ADRBK10.53481324
78BUB10.52806145
79PRKD20.52709726
80PLK40.52380380
81CSNK1A1L0.50469520
82IRAK10.49111530
83ATM0.48485961
84NUAK10.47992948
85MAPK110.47805253
86GSK3A0.47786248
87CDK30.47759457
88SGK30.45465063
89CSNK1A10.45236026
90PDPK10.43778490
91PRKACB0.43141712
92PAK10.42453408
93PTK20.42158545
94MTOR0.42059381
95STK38L0.41307930
96PRKACA0.40971327
97EIF2AK30.39057621
98TRIM280.38280234
99MAP2K40.37119315
100SGK10.36342377
101BRSK20.36020855
102MAP3K100.35656589
103SGK20.35633937
104PRKCH0.35629622
105BRAF0.34655944
106ZAK0.33876672
107CHUK0.32695888
108MAP2K10.32575230
109LIMK10.32247650
110PRKCA0.32070188
111PRKG10.30903307
112CAMK2A0.30845885
113BRSK10.30247947
114STK100.30053052
115PAK20.29567976
116CAMK1G0.29134479
117MUSK0.28529028
118PAK40.28437520
119FLT30.26286804
120NTRK20.25610729
121CDK70.25464366
122PIM10.22328471
123STK40.22190489
124AURKA0.21492711
125MARK20.20082982
126BMPR1B0.19945790
127CDK20.19106485
128CDK40.18366636
129LMTK20.18289555
130PRKAA10.17501096
131AURKB0.17185483
132TAOK10.16171080
133RPS6KB10.16081569
134CDK10.15873871
135MAP2K60.15082194
136CAMKK10.14838128
137PRKCG0.14667778
138RIPK40.13334267
139RPS6KA10.13041555
140CSNK2A10.12496486
141IRAK20.11865262
142EIF2AK10.11823934
143YES10.11334750
144MARK30.10130619
145BRD40.09476204
146CDK60.09245247
147GSK3B0.08536517
148VRK10.08436792
149CDK150.08329986
150CLK10.08127878
151TLK10.07836538
152CDK11A0.06385845
153ZAP700.05640637
154CDK180.05336514
155PRKDC0.05220138
156MAP4K10.04948909
157TRIB30.04769193
158CSNK2A20.04623811
159SRPK10.04049393
160MAPKAPK50.03672633
161MAP3K80.03591591
162STK110.02999378
163CSF1R0.02639490
164PLK30.02258409
165MAPK80.01630015
166PRKCZ0.01584858
167CDK140.01160560
168CDK90.00544491
169CSNK1D0.00034228

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.96241288
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.05443249
3Vitamin B6 metabolism_Homo sapiens_hsa007503.86288028
4Fatty acid biosynthesis_Homo sapiens_hsa000613.71797982
5Pyruvate metabolism_Homo sapiens_hsa006203.50364187
6Basal transcription factors_Homo sapiens_hsa030223.25412545
7Protein export_Homo sapiens_hsa030603.08849596
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87906469
9Insulin secretion_Homo sapiens_hsa049112.87847377
10Linoleic acid metabolism_Homo sapiens_hsa005912.78765398
11Fanconi anemia pathway_Homo sapiens_hsa034602.77429404
12Selenocompound metabolism_Homo sapiens_hsa004502.72307034
13Butanoate metabolism_Homo sapiens_hsa006502.70985283
14Sulfur metabolism_Homo sapiens_hsa009202.46864451
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42711831
16Glucagon signaling pathway_Homo sapiens_hsa049222.39122396
17Propanoate metabolism_Homo sapiens_hsa006402.34910049
18Collecting duct acid secretion_Homo sapiens_hsa049662.31181719
19Dorso-ventral axis formation_Homo sapiens_hsa043202.30237606
20Pentose phosphate pathway_Homo sapiens_hsa000302.28920311
21Oxidative phosphorylation_Homo sapiens_hsa001902.25314401
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22987855
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13998300
24Oocyte meiosis_Homo sapiens_hsa041142.02036273
25Fatty acid elongation_Homo sapiens_hsa000621.97541273
26RNA transport_Homo sapiens_hsa030131.96002572
27DNA replication_Homo sapiens_hsa030301.93681458
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91614030
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.80501575
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78576993
31mRNA surveillance pathway_Homo sapiens_hsa030151.75145225
32Glycerolipid metabolism_Homo sapiens_hsa005611.70104891
33Folate biosynthesis_Homo sapiens_hsa007901.68647302
34Homologous recombination_Homo sapiens_hsa034401.68046602
35Regulation of autophagy_Homo sapiens_hsa041401.63313419
36Circadian rhythm_Homo sapiens_hsa047101.61713901
37Type I diabetes mellitus_Homo sapiens_hsa049401.56486963
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54508005
39Fructose and mannose metabolism_Homo sapiens_hsa000511.51136729
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.50515404
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.50376672
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.47543163
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47326225
44Type II diabetes mellitus_Homo sapiens_hsa049301.46246739
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45943006
46Antigen processing and presentation_Homo sapiens_hsa046121.40085002
47Huntingtons disease_Homo sapiens_hsa050161.37603713
48Carbon metabolism_Homo sapiens_hsa012001.36609400
49PPAR signaling pathway_Homo sapiens_hsa033201.35191384
50Tryptophan metabolism_Homo sapiens_hsa003801.34232332
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32393160
52Cell cycle_Homo sapiens_hsa041101.27858543
53beta-Alanine metabolism_Homo sapiens_hsa004101.26776549
54Synaptic vesicle cycle_Homo sapiens_hsa047211.26027754
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24256105
56Purine metabolism_Homo sapiens_hsa002301.22639866
57Fat digestion and absorption_Homo sapiens_hsa049751.22182974
58Peroxisome_Homo sapiens_hsa041461.21641581
59Vibrio cholerae infection_Homo sapiens_hsa051101.21496298
60Base excision repair_Homo sapiens_hsa034101.20777198
61Ether lipid metabolism_Homo sapiens_hsa005651.16452947
62Parkinsons disease_Homo sapiens_hsa050121.15661434
63Systemic lupus erythematosus_Homo sapiens_hsa053221.14122971
64Mismatch repair_Homo sapiens_hsa034301.13980356
65Amphetamine addiction_Homo sapiens_hsa050311.10642534
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10353567
67Biosynthesis of amino acids_Homo sapiens_hsa012301.06366803
68Fatty acid metabolism_Homo sapiens_hsa012121.05682858
69Pyrimidine metabolism_Homo sapiens_hsa002401.02681426
70Alzheimers disease_Homo sapiens_hsa050101.01115255
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98077967
72Phototransduction_Homo sapiens_hsa047440.97163220
73Glutathione metabolism_Homo sapiens_hsa004800.96755829
74Fatty acid degradation_Homo sapiens_hsa000710.95082105
75Cardiac muscle contraction_Homo sapiens_hsa042600.93978127
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.90670093
77Mineral absorption_Homo sapiens_hsa049780.90007635
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89685092
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86405092
80Other glycan degradation_Homo sapiens_hsa005110.85525218
81Nucleotide excision repair_Homo sapiens_hsa034200.85036453
82Hedgehog signaling pathway_Homo sapiens_hsa043400.81213090
83RNA degradation_Homo sapiens_hsa030180.80202412
84Sphingolipid metabolism_Homo sapiens_hsa006000.79028199
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78600390
86Non-homologous end-joining_Homo sapiens_hsa034500.78518877
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78067323
88Circadian entrainment_Homo sapiens_hsa047130.77465527
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73980898
90Spliceosome_Homo sapiens_hsa030400.73461086
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72736796
92Legionellosis_Homo sapiens_hsa051340.71487157
93Arachidonic acid metabolism_Homo sapiens_hsa005900.70637483
94Dopaminergic synapse_Homo sapiens_hsa047280.67903223
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66825232
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.64658666
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64051942
98Ovarian steroidogenesis_Homo sapiens_hsa049130.63281849
99Lysosome_Homo sapiens_hsa041420.62553737
100ABC transporters_Homo sapiens_hsa020100.60804707
101Renin secretion_Homo sapiens_hsa049240.60151414
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59343419
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59172646
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58197010
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56854615
106Salivary secretion_Homo sapiens_hsa049700.56478504
107Retinol metabolism_Homo sapiens_hsa008300.55559368
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55410161
109Viral carcinogenesis_Homo sapiens_hsa052030.53487515
110Pancreatic secretion_Homo sapiens_hsa049720.53432495
111Alcoholism_Homo sapiens_hsa050340.53336440
112Nitrogen metabolism_Homo sapiens_hsa009100.52545626
113Steroid biosynthesis_Homo sapiens_hsa001000.51745303
114Chemical carcinogenesis_Homo sapiens_hsa052040.51524767
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50911188
116Estrogen signaling pathway_Homo sapiens_hsa049150.50850050
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.49198683
118Serotonergic synapse_Homo sapiens_hsa047260.48902809
119One carbon pool by folate_Homo sapiens_hsa006700.48569600
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47178380
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.46754456
122GABAergic synapse_Homo sapiens_hsa047270.44135757
123p53 signaling pathway_Homo sapiens_hsa041150.44133891
124RNA polymerase_Homo sapiens_hsa030200.43008666
125N-Glycan biosynthesis_Homo sapiens_hsa005100.41974479
126Long-term depression_Homo sapiens_hsa047300.40733317
127AMPK signaling pathway_Homo sapiens_hsa041520.40618867
128Insulin resistance_Homo sapiens_hsa049310.39924928
129VEGF signaling pathway_Homo sapiens_hsa043700.39187544
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39104436
131Endocytosis_Homo sapiens_hsa041440.38833185
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38491512
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37997902
134Caffeine metabolism_Homo sapiens_hsa002320.37330947
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37142333
136Long-term potentiation_Homo sapiens_hsa047200.37053990
137Metabolic pathways_Homo sapiens_hsa011000.36904799
138Arginine and proline metabolism_Homo sapiens_hsa003300.36593747
139Glutamatergic synapse_Homo sapiens_hsa047240.36534711
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36517396
141Epstein-Barr virus infection_Homo sapiens_hsa051690.35878104
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35560734
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35327336
144Proteasome_Homo sapiens_hsa030500.34885767
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34560841
146Sulfur relay system_Homo sapiens_hsa041220.29250609
147Thyroid hormone synthesis_Homo sapiens_hsa049180.23758193
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23039958
149Inositol phosphate metabolism_Homo sapiens_hsa005620.21068423
150Bile secretion_Homo sapiens_hsa049760.20662879
151Basal cell carcinoma_Homo sapiens_hsa052170.20203216
152HTLV-I infection_Homo sapiens_hsa051660.20179603
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19993715
154B cell receptor signaling pathway_Homo sapiens_hsa046620.19528121
155Herpes simplex infection_Homo sapiens_hsa051680.18582352
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18384244
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17126029
158HIF-1 signaling pathway_Homo sapiens_hsa040660.13726879
159Renin-angiotensin system_Homo sapiens_hsa046140.13695462
160Wnt signaling pathway_Homo sapiens_hsa043100.11989029
161Influenza A_Homo sapiens_hsa051640.11630755

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