SYNJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.03968968
2synaptic vesicle exocytosis (GO:0016079)5.53088369
3synaptic vesicle maturation (GO:0016188)5.45585913
4locomotory exploration behavior (GO:0035641)5.40663497
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.39553088
6vocalization behavior (GO:0071625)5.33499660
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20289280
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.13304779
9glutamate secretion (GO:0014047)5.09278244
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.03499728
11regulation of synaptic vesicle exocytosis (GO:2000300)4.91119932
12regulation of glutamate receptor signaling pathway (GO:1900449)4.88297318
13protein localization to synapse (GO:0035418)4.67321715
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.61595062
15neuron cell-cell adhesion (GO:0007158)4.55513348
16neuronal action potential propagation (GO:0019227)4.47821614
17cerebellar granule cell differentiation (GO:0021707)4.46972034
18glutamate receptor signaling pathway (GO:0007215)4.43739858
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.41496465
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40289543
21exploration behavior (GO:0035640)4.36123718
22neurotransmitter secretion (GO:0007269)4.34522337
23regulation of neuronal synaptic plasticity (GO:0048168)4.30888913
24synaptic transmission, glutamatergic (GO:0035249)4.30139854
25* regulation of synaptic vesicle transport (GO:1902803)4.21928735
26neuron-neuron synaptic transmission (GO:0007270)4.12584836
27regulation of ARF protein signal transduction (GO:0032012)4.11854160
28amino acid import (GO:0043090)3.91199978
29long-term memory (GO:0007616)3.89316445
30regulation of excitatory postsynaptic membrane potential (GO:0060079)3.85214931
31regulation of synapse structural plasticity (GO:0051823)3.83694568
32gamma-aminobutyric acid transport (GO:0015812)3.81655422
33cellular potassium ion homeostasis (GO:0030007)3.80061360
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.79373817
35proline transport (GO:0015824)3.75951943
36neurotransmitter-gated ion channel clustering (GO:0072578)3.75195234
37potassium ion homeostasis (GO:0055075)3.69158873
38regulation of postsynaptic membrane potential (GO:0060078)3.68553976
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68247120
40neuron recognition (GO:0008038)3.64631821
41layer formation in cerebral cortex (GO:0021819)3.63863048
42positive regulation of membrane potential (GO:0045838)3.62541218
43regulation of synaptic plasticity (GO:0048167)3.61180663
44long-term synaptic potentiation (GO:0060291)3.60535769
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59226182
46* neurotransmitter transport (GO:0006836)3.58279790
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52623586
48response to histamine (GO:0034776)3.49338886
49dendritic spine morphogenesis (GO:0060997)3.48503159
50potassium ion import (GO:0010107)3.47443073
51* synaptic vesicle endocytosis (GO:0048488)3.46531932
52cerebellar Purkinje cell differentiation (GO:0021702)3.42009275
53positive regulation of synapse maturation (GO:0090129)3.39524318
54regulation of neurotransmitter secretion (GO:0046928)3.38555644
55negative regulation of dendrite morphogenesis (GO:0050774)3.37850763
56regulation of neurotransmitter levels (GO:0001505)3.37469576
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.34898832
58transmission of nerve impulse (GO:0019226)3.33724562
59sodium ion export (GO:0071436)3.33286460
60regulation of vesicle fusion (GO:0031338)3.33218171
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31058376
62regulation of dendritic spine morphogenesis (GO:0061001)3.30556412
63activation of protein kinase A activity (GO:0034199)3.29993237
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26567978
65axonal fasciculation (GO:0007413)3.24934383
66neuromuscular process controlling posture (GO:0050884)3.21255133
67behavioral defense response (GO:0002209)3.21025000
68behavioral fear response (GO:0001662)3.21025000
69cellular sodium ion homeostasis (GO:0006883)3.20553393
70vesicle transport along microtubule (GO:0047496)3.20420598
71presynaptic membrane assembly (GO:0097105)3.18834797
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18660177
73regulation of voltage-gated calcium channel activity (GO:1901385)3.17763156
74membrane depolarization (GO:0051899)3.17697586
75postsynaptic membrane organization (GO:0001941)3.14142579
76membrane depolarization during action potential (GO:0086010)3.13476095
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12985837
78positive regulation of neurotransmitter secretion (GO:0001956)3.12273807
79regulation of neurotransmitter transport (GO:0051588)3.11768446
80cell differentiation in hindbrain (GO:0021533)3.11484179
81neuromuscular process controlling balance (GO:0050885)3.11479949
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09039955
83positive regulation of neurotransmitter transport (GO:0051590)3.08639222
84startle response (GO:0001964)3.07773645
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06866219
86regulation of exocytosis (GO:0017157)3.03852483
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03710507
88fear response (GO:0042596)3.03504817
89innervation (GO:0060384)3.03210250
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01621295
91membrane hyperpolarization (GO:0060081)2.99817263
92* learning (GO:0007612)2.99687377
93dendrite morphogenesis (GO:0048813)2.99378747
94* regulation of synaptic transmission (GO:0050804)2.98817510
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98314932
96synaptic transmission (GO:0007268)2.98040011
97intraspecies interaction between organisms (GO:0051703)2.97121399
98social behavior (GO:0035176)2.97121399
99presynaptic membrane organization (GO:0097090)2.96767352
100response to auditory stimulus (GO:0010996)2.96508534
101detection of calcium ion (GO:0005513)2.95616275
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95513680
103regulation of clathrin-mediated endocytosis (GO:2000369)2.95341185
104positive regulation of dendritic spine development (GO:0060999)2.93999695
105synapse assembly (GO:0007416)2.93859956
106L-amino acid import (GO:0043092)2.92354577
107central nervous system myelination (GO:0022010)2.92337548
108axon ensheathment in central nervous system (GO:0032291)2.92337548
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90524398
110* positive regulation of synaptic transmission (GO:0050806)2.89137618
111regulation of dendritic spine development (GO:0060998)2.88422300
112chemosensory behavior (GO:0007635)2.87839033
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.85473801
114adult walking behavior (GO:0007628)2.85275961
115neuronal ion channel clustering (GO:0045161)2.84987187
116cell communication by electrical coupling (GO:0010644)2.84246340
117mating behavior (GO:0007617)2.84191940
118regulation of synapse maturation (GO:0090128)2.83502730
119behavioral response to cocaine (GO:0048148)2.83444041
120* synaptic vesicle transport (GO:0048489)2.80398673
121* establishment of synaptic vesicle localization (GO:0097480)2.80398673
122negative regulation of neurotransmitter transport (GO:0051589)2.79106477
123clathrin coat assembly (GO:0048268)2.77836443
124cytoskeletal anchoring at plasma membrane (GO:0007016)2.75373885
125serotonin metabolic process (GO:0042428)2.73736391
126positive regulation of Rap GTPase activity (GO:0032854)2.72953647
127regulation of Rap GTPase activity (GO:0032317)2.71234266
128acidic amino acid transport (GO:0015800)2.67647955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97095838
2GBX2_23144817_ChIP-Seq_PC3_Human3.77096654
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01942303
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91399049
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91132241
6REST_21632747_ChIP-Seq_MESCs_Mouse2.64293309
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55642836
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50611642
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50611642
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41826905
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41725040
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41382930
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41081630
14DROSHA_22980978_ChIP-Seq_HELA_Human2.39471559
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.38966659
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33132369
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.20938825
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18910179
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.09369431
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.09244561
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07527133
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.03491902
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.01822905
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91720328
25AR_21572438_ChIP-Seq_LNCaP_Human1.86542408
26TAF15_26573619_Chip-Seq_HEK293_Human1.83006714
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82225222
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81913491
29SMAD4_21799915_ChIP-Seq_A2780_Human1.81068001
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75495331
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75000171
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74606523
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74004480
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68884594
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66055246
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.60582889
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58040256
38P300_19829295_ChIP-Seq_ESCs_Human1.55495697
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52467118
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52121810
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51701836
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41874969
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37014434
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36557740
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36446023
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.35948289
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.35268912
48IGF1R_20145208_ChIP-Seq_DFB_Human1.35140389
49* AR_25329375_ChIP-Seq_VCAP_Human1.34365739
50* STAT3_23295773_ChIP-Seq_U87_Human1.33064977
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29438440
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29335632
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28937791
54KDM2B_26808549_Chip-Seq_K562_Human1.26883708
55ZNF274_21170338_ChIP-Seq_K562_Hela1.24911068
56* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24556520
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.23515381
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.22488064
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22152016
60AR_19668381_ChIP-Seq_PC3_Human1.21772525
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20444356
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20011539
63* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19729360
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18591520
65TCF4_23295773_ChIP-Seq_U87_Human1.17747824
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17269150
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15823047
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15634787
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15285998
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.15239804
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15130515
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14791921
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.14576701
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13550437
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.13073306
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.11173310
77TP53_16413492_ChIP-PET_HCT116_Human1.10638950
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09380683
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09262164
80AHR_22903824_ChIP-Seq_MCF-7_Human1.09190103
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07790587
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06291148
83RUNX2_22187159_ChIP-Seq_PCA_Human1.05188322
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05121906
85FUS_26573619_Chip-Seq_HEK293_Human1.05052402
86RNF2_27304074_Chip-Seq_NSC_Mouse1.04626895
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03674953
88ER_23166858_ChIP-Seq_MCF-7_Human1.03672431
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02646446
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01266071
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01216185
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00256901
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99853256
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99001942
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97811639
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97400578
97ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96901526
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.96877144
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.96664093
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.95906960
101JUN_21703547_ChIP-Seq_K562_Human0.95466977
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95143518
103RING1B_27294783_Chip-Seq_NPCs_Mouse0.94896644
104ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94673918
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94614955
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94614955
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94327369
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93959009
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93449792
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92942920
111TP53_18474530_ChIP-ChIP_U2OS_Human0.92590145
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92583675
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92304344
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91808486
115RXR_22108803_ChIP-Seq_LS180_Human0.91487480
116* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91097937
117BCAT_22108803_ChIP-Seq_LS180_Human0.90799406
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90415448
119* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90257747
120FLI1_21867929_ChIP-Seq_TH2_Mouse0.90195150
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89483387
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89471434
123KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89139825
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88512324
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87331126
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86176395
127KDM2B_26808549_Chip-Seq_REH_Human0.85777931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.61733948
2MP0003880_abnormal_central_pattern5.14263168
3* MP0003635_abnormal_synaptic_transmissio4.20481263
4MP0004270_analgesia3.60176644
5MP0009745_abnormal_behavioral_response3.52265507
6MP0002063_abnormal_learning/memory/cond3.40552468
7* MP0002064_seizures3.28341856
8MP0009046_muscle_twitch3.25099353
9MP0001968_abnormal_touch/_nociception3.05285263
10MP0002572_abnormal_emotion/affect_behav2.92683947
11MP0005423_abnormal_somatic_nervous2.68098822
12MP0001501_abnormal_sleep_pattern2.66973025
13MP0002272_abnormal_nervous_system2.65995575
14MP0002822_catalepsy2.62905401
15MP0001486_abnormal_startle_reflex2.54772980
16MP0002734_abnormal_mechanical_nocicepti2.52553251
17MP0002736_abnormal_nociception_after2.42202811
18MP0002735_abnormal_chemical_nociception2.38261943
19MP0001440_abnormal_grooming_behavior2.27826243
20MP0002067_abnormal_sensory_capabilities2.04696836
21MP0002733_abnormal_thermal_nociception2.04277608
22MP0001970_abnormal_pain_threshold1.95929807
23MP0006276_abnormal_autonomic_nervous1.83864046
24MP0005386_behavior/neurological_phenoty1.83620974
25MP0004924_abnormal_behavior1.83620974
26MP0008569_lethality_at_weaning1.79493684
27MP0003329_amyloid_beta_deposits1.79216594
28MP0009780_abnormal_chondrocyte_physiolo1.79003839
29MP0002184_abnormal_innervation1.73767754
30MP0003787_abnormal_imprinting1.73311243
31MP0002557_abnormal_social/conspecific_i1.72688617
32MP0004858_abnormal_nervous_system1.71840327
33MP0000778_abnormal_nervous_system1.71119313
34MP0004811_abnormal_neuron_physiology1.70609538
35MP0005646_abnormal_pituitary_gland1.69477431
36MP0002909_abnormal_adrenal_gland1.65027499
37MP0003879_abnormal_hair_cell1.52172892
38MP0001984_abnormal_olfaction1.51477861
39MP0000569_abnormal_digit_pigmentation1.49114987
40MP0005645_abnormal_hypothalamus_physiol1.45889686
41MP0000955_abnormal_spinal_cord1.42880274
42MP0004885_abnormal_endolymph1.42510268
43MP0002882_abnormal_neuron_morphology1.40431069
44* MP0002066_abnormal_motor_capabilities/c1.39771395
45MP0003633_abnormal_nervous_system1.38967461
46MP0001502_abnormal_circadian_rhythm1.35501553
47MP0008877_abnormal_DNA_methylation1.33212784
48MP0001905_abnormal_dopamine_level1.31983185
49MP0001529_abnormal_vocalization1.31066767
50MP0003122_maternal_imprinting1.29290618
51MP0004142_abnormal_muscle_tone1.27757357
52MP0001188_hyperpigmentation1.23944323
53MP0005551_abnormal_eye_electrophysiolog1.20160171
54MP0003631_nervous_system_phenotype1.15986759
55MP0002229_neurodegeneration1.09511850
56MP0004510_myositis1.04584256
57MP0002152_abnormal_brain_morphology1.02776910
58MP0010386_abnormal_urinary_bladder1.00094884
59MP0008872_abnormal_physiological_respon0.99033920
60MP0005535_abnormal_body_temperature0.96676223
61MP0008874_decreased_physiological_sensi0.95990289
62MP0004742_abnormal_vestibular_system0.95740190
63MP0000604_amyloidosis0.94973614
64MP0003690_abnormal_glial_cell0.94319634
65MP0001986_abnormal_taste_sensitivity0.94113897
66MP0002069_abnormal_eating/drinking_beha0.91325581
67MP0003172_abnormal_lysosome_physiology0.90228143
68MP0003075_altered_response_to0.89913364
69MP0004145_abnormal_muscle_electrophysio0.89344047
70MP0003634_abnormal_glial_cell0.87733687
71MP0003303_peritoneal_inflammation0.87208490
72MP0001348_abnormal_lacrimal_gland0.84243586
73MP0001963_abnormal_hearing_physiology0.82217260
74MP0003123_paternal_imprinting0.81844765
75MP0001177_atelectasis0.81659274
76MP0000920_abnormal_myelination0.80312018
77MP0000751_myopathy0.79975081
78MP0003632_abnormal_nervous_system0.79651752
79MP0002837_dystrophic_cardiac_calcinosis0.78416202
80MP0002090_abnormal_vision0.78230827
81MP0004130_abnormal_muscle_cell0.76717319
82MP0004085_abnormal_heartbeat0.76486193
83MP0003183_abnormal_peptide_metabolism0.74982348
84MP0002638_abnormal_pupillary_reflex0.74569184
85MP0002876_abnormal_thyroid_physiology0.74475985
86MP0005394_taste/olfaction_phenotype0.73338615
87MP0005499_abnormal_olfactory_system0.73338615
88MP0008961_abnormal_basal_metabolism0.72489473
89MP0002752_abnormal_somatic_nervous0.72388682
90MP0008260_abnormal_autophagy0.72361093
91MP0003121_genomic_imprinting0.71112441
92MP0004484_altered_response_of0.70273703
93MP0003724_increased_susceptibility_to0.69363608
94MP0000013_abnormal_adipose_tissue0.68693518
95MP0000015_abnormal_ear_pigmentation0.68143210
96MP0004147_increased_porphyrin_level0.67377635
97MP0005167_abnormal_blood-brain_barrier0.66538218
98MP0005409_darkened_coat_color0.66170715
99MP0003045_fibrosis0.65094248
100MP0000631_abnormal_neuroendocrine_gland0.64404281
101MP0004215_abnormal_myocardial_fiber0.63756991
102MP0001485_abnormal_pinna_reflex0.58060065
103MP0001664_abnormal_digestion0.57447626
104MP0005166_decreased_susceptibility_to0.55575046
105MP0006072_abnormal_retinal_apoptosis0.50819977
106MP0005253_abnormal_eye_physiology0.50020380
107MP0001943_abnormal_respiration0.49891529
108MP0005174_abnormal_tail_pigmentation0.49581846
109MP0003283_abnormal_digestive_organ0.49103085
110MP0002332_abnormal_exercise_endurance0.47978072
111* MP0010769_abnormal_survival0.47266864
112MP0003956_abnormal_body_size0.46825097
113MP0004043_abnormal_pH_regulation0.46174006
114* MP0010770_preweaning_lethality0.46026575
115* MP0002082_postnatal_lethality0.46026575
116MP0001765_abnormal_ion_homeostasis0.45795655
117* MP0010768_mortality/aging0.45405057
118MP0005388_respiratory_system_phenotype0.44905621
119MP0002133_abnormal_respiratory_system0.44905621
120MP0002083_premature_death0.44388447

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.07859192
2Myokymia (HP:0002411)6.40205856
3Focal seizures (HP:0007359)5.97971276
4Visual hallucinations (HP:0002367)5.36500464
5Epileptic encephalopathy (HP:0200134)5.21764423
6Febrile seizures (HP:0002373)4.94889801
7Atonic seizures (HP:0010819)4.91968597
8Progressive cerebellar ataxia (HP:0002073)4.57619356
9Absence seizures (HP:0002121)4.47157710
10Generalized tonic-clonic seizures (HP:0002069)4.15607440
11Dialeptic seizures (HP:0011146)4.11723430
12Action tremor (HP:0002345)3.78048048
13Broad-based gait (HP:0002136)3.73957217
14Hyperventilation (HP:0002883)3.72073580
15Gaze-evoked nystagmus (HP:0000640)3.46035275
16Poor eye contact (HP:0000817)3.44850294
17Dysmetria (HP:0001310)3.22321997
18Dysdiadochokinesis (HP:0002075)3.20477627
19Truncal ataxia (HP:0002078)3.19173539
20Impaired social interactions (HP:0000735)3.18514243
21Abnormal social behavior (HP:0012433)3.18514243
22Depression (HP:0000716)3.16520948
23Urinary bladder sphincter dysfunction (HP:0002839)3.15366274
24Impaired vibration sensation in the lower limbs (HP:0002166)3.13611163
25Papilledema (HP:0001085)3.12898808
26Excessive salivation (HP:0003781)3.08157934
27Drooling (HP:0002307)3.08157934
28Mutism (HP:0002300)3.03813622
29Ankle clonus (HP:0011448)3.01548590
30Tetraplegia (HP:0002445)2.99628865
31Anxiety (HP:0000739)2.97079339
32Genetic anticipation (HP:0003743)2.96950735
33* Supranuclear gaze palsy (HP:0000605)2.96692642
34Amblyopia (HP:0000646)2.95683667
35Progressive inability to walk (HP:0002505)2.93470423
36Abnormal eating behavior (HP:0100738)2.93346703
37Abnormality of binocular vision (HP:0011514)2.86108248
38Diplopia (HP:0000651)2.86108248
39Impaired smooth pursuit (HP:0007772)2.84116520
40Cerebral inclusion bodies (HP:0100314)2.82505557
41Apathy (HP:0000741)2.79699777
42Neurofibrillary tangles (HP:0002185)2.76419295
43Peripheral hypomyelination (HP:0007182)2.72872696
44Absent speech (HP:0001344)2.71395635
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70125069
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.66801808
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.66801808
48Hemiparesis (HP:0001269)2.66033216
49Akinesia (HP:0002304)2.62970480
50Slow saccadic eye movements (HP:0000514)2.59662290
51Diminished motivation (HP:0000745)2.58916902
52Epileptiform EEG discharges (HP:0011182)2.49529146
53Spastic gait (HP:0002064)2.49402471
54* Postural instability (HP:0002172)2.49019579
55Urinary urgency (HP:0000012)2.47978621
56Scanning speech (HP:0002168)2.47926966
57Abnormality of ocular smooth pursuit (HP:0000617)2.44853616
58Stereotypic behavior (HP:0000733)2.43547475
59Annular pancreas (HP:0001734)2.42926331
60* Rigidity (HP:0002063)2.40642027
61Clonus (HP:0002169)2.34036781
62Hemiplegia (HP:0002301)2.33761659
63EEG with generalized epileptiform discharges (HP:0011198)2.31436877
64Inability to walk (HP:0002540)2.31380950
65Limb dystonia (HP:0002451)2.30502114
66Status epilepticus (HP:0002133)2.29656931
67Polyphagia (HP:0002591)2.27723270
68Insidious onset (HP:0003587)2.27341586
69Termporal pattern (HP:0011008)2.27341586
70Generalized myoclonic seizures (HP:0002123)2.27189660
71Intention tremor (HP:0002080)2.25915449
72* Bradykinesia (HP:0002067)2.25854273
73Dysmetric saccades (HP:0000641)2.24601827
74Pheochromocytoma (HP:0002666)2.23517888
75Blue irides (HP:0000635)2.22973024
76Protruding tongue (HP:0010808)2.22115118
77Torticollis (HP:0000473)2.21570623
78Abnormality of the corticospinal tract (HP:0002492)2.20289171
79Abnormality of the lower motor neuron (HP:0002366)2.18672926
80Impaired vibratory sensation (HP:0002495)2.16309713
81Lower limb muscle weakness (HP:0007340)2.15705626
82Abnormality of salivation (HP:0100755)2.15589368
83Hypsarrhythmia (HP:0002521)2.14938642
84Fetal akinesia sequence (HP:0001989)2.14919559
85Inappropriate behavior (HP:0000719)2.13421508
86Psychosis (HP:0000709)2.11112773
87Spastic tetraparesis (HP:0001285)2.07568376
88Memory impairment (HP:0002354)2.07544586
89Focal dystonia (HP:0004373)2.07213669
90Papillary thyroid carcinoma (HP:0002895)2.06298161
91Agitation (HP:0000713)2.05801625
92Cerebral hypomyelination (HP:0006808)2.03741734
93Increased circulating renin level (HP:0000848)2.03162639
94Gait ataxia (HP:0002066)2.01340004
95Morphological abnormality of the pyramidal tract (HP:0002062)2.01089941
96Neuronal loss in central nervous system (HP:0002529)2.00832614
97Ocular albinism (HP:0001107)1.97434457
98Bundle branch block (HP:0011710)1.94722996
99Ventricular fibrillation (HP:0001663)1.94698653
100Neuroendocrine neoplasm (HP:0100634)1.94215641
101Abnormality of saccadic eye movements (HP:0000570)1.91416751
102Gait imbalance (HP:0002141)1.90295741
103Thickened helices (HP:0000391)1.89618855
104Widely spaced teeth (HP:0000687)1.89434594
105Sleep apnea (HP:0010535)1.88887218
106Iris hypopigmentation (HP:0007730)1.87135726
107Decreased motor nerve conduction velocity (HP:0003431)1.86845047
108Generalized hypopigmentation of hair (HP:0011358)1.85551772
109Incomplete penetrance (HP:0003829)1.85530972
110Postural tremor (HP:0002174)1.84087257
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81380769
112Lower limb amyotrophy (HP:0007210)1.81109687
113Rapidly progressive (HP:0003678)1.78154196
114Obstructive sleep apnea (HP:0002870)1.78093465
115Failure to thrive in infancy (HP:0001531)1.76893890
116Craniofacial dystonia (HP:0012179)1.76662032
117Specific learning disability (HP:0001328)1.73983868
118Hypoventilation (HP:0002791)1.73224572
119Abnormal hair whorl (HP:0010721)1.71942620
120Amyotrophic lateral sclerosis (HP:0007354)1.70897792
121Delusions (HP:0000746)1.70747316
122Clumsiness (HP:0002312)1.70336814
123Abnormal EKG (HP:0003115)1.70192952
124Aqueductal stenosis (HP:0002410)1.70032192
125Megalencephaly (HP:0001355)1.69371944
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68586145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.01810297
2EPHA44.18147662
3MAP3K93.80706748
4MAP3K43.19890855
5RIPK42.90208863
6MAP2K72.74139073
7MINK12.59628735
8MARK12.58670742
9MAP3K122.31752706
10DAPK22.19794091
11KSR22.06498331
12CASK2.03347793
13PAK62.02962521
14MAP2K41.99794887
15NTRK21.92845741
16PLK21.72792335
17PNCK1.70226536
18NTRK11.66627363
19MAP3K131.65118928
20TNIK1.59841497
21ARAF1.58924321
22CAMKK11.58039801
23PRKD31.56682695
24KSR11.54668639
25DAPK11.50112506
26CDK51.49180622
27GRK51.48223497
28FES1.46285993
29SIK21.44378163
30STK381.35766955
31BMPR21.30191441
32PRPF4B1.26110586
33CDK191.22163211
34PRKCG1.17634765
35MAPK131.15249537
36CAMK2A1.12708779
37RIPK11.12114607
38MAP3K21.09295711
39CAMKK21.07856321
40MAP3K110.95644928
41PTK2B0.95482840
42SGK2230.93939905
43SGK4940.93939905
44MAPK120.92413909
45RAF10.92295848
46SGK20.91272872
47CAMK2B0.90759284
48CAMK10.90381054
49UHMK10.89623618
50CAMK1D0.85511050
51STK110.85179430
52SGK10.82653628
53TYRO30.78763861
54SGK30.78282434
55CDK180.76848206
56RET0.76049479
57OXSR10.74599557
58CDK140.74435556
59CDK150.74311123
60PRKCH0.74282326
61CAMK1G0.73144526
62FGR0.72084279
63LATS20.71929824
64TAOK10.71247652
65JAK20.69539992
66PDK10.69208664
67DYRK1A0.69081899
68PHKG20.69064160
69PHKG10.69064160
70JAK10.68639263
71PINK10.66313181
72PAK30.65508192
73CDK120.64976422
74MAP3K10.64524961
75CSNK1G20.63628889
76CDK11A0.63223273
77TNK20.62971520
78MARK20.62407489
79PDPK10.61585792
80NME10.60804645
81PRKCE0.57592329
82CAMK2D0.54450841
83AKT30.49879483
84WNK10.49711675
85BRD40.48993672
86MAP3K50.48971656
87RPS6KA30.48971094
88CAMK2G0.48869878
89YES10.47549260
90BLK0.47508108
91MAP3K60.46836901
92SIK30.46391018
93PRKCZ0.46182742
94FYN0.46002396
95MAPK100.45972522
96ALK0.45698405
97LMTK20.45296328
98GRK70.43938144
99MOS0.43339627
100NEK60.41386635
101IRAK20.38730579
102CAMK40.38133338
103CDC42BPA0.37769793
104MAP3K70.36838015
105SYK0.36151830
106BRAF0.35184033
107DMPK0.34724511
108FER0.33849130
109WNK30.33541634
110PRKCB0.33206476
111MAP2K10.32252894
112SCYL20.31456922
113MAPKAPK50.31305867
114PRKG10.30668695

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82285876
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26549194
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71087191
4Long-term potentiation_Homo sapiens_hsa047202.70849471
5GABAergic synapse_Homo sapiens_hsa047272.65787292
6Olfactory transduction_Homo sapiens_hsa047402.63881665
7Circadian entrainment_Homo sapiens_hsa047132.63164721
8Glutamatergic synapse_Homo sapiens_hsa047242.54403149
9Morphine addiction_Homo sapiens_hsa050322.49772127
10Amphetamine addiction_Homo sapiens_hsa050312.46381002
11Salivary secretion_Homo sapiens_hsa049702.16444300
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14505060
13Dopaminergic synapse_Homo sapiens_hsa047282.12838798
14Insulin secretion_Homo sapiens_hsa049111.95170983
15Gastric acid secretion_Homo sapiens_hsa049711.82487073
16Cholinergic synapse_Homo sapiens_hsa047251.82048802
17Taste transduction_Homo sapiens_hsa047421.79588373
18Serotonergic synapse_Homo sapiens_hsa047261.75412174
19Collecting duct acid secretion_Homo sapiens_hsa049661.74679896
20Long-term depression_Homo sapiens_hsa047301.74677453
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74346456
22Renin secretion_Homo sapiens_hsa049241.70884781
23Cocaine addiction_Homo sapiens_hsa050301.60498458
24Oxytocin signaling pathway_Homo sapiens_hsa049211.59302078
25Calcium signaling pathway_Homo sapiens_hsa040201.57945092
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51013769
27GnRH signaling pathway_Homo sapiens_hsa049121.42668721
28Phototransduction_Homo sapiens_hsa047441.35462094
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35397567
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34334053
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28920219
32cAMP signaling pathway_Homo sapiens_hsa040241.26188386
33Type II diabetes mellitus_Homo sapiens_hsa049301.22741595
34Gap junction_Homo sapiens_hsa045401.21418046
35* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15006867
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10974804
37Estrogen signaling pathway_Homo sapiens_hsa049151.08060380
38Glioma_Homo sapiens_hsa052141.06890218
39Vibrio cholerae infection_Homo sapiens_hsa051101.05834129
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03529031
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00637183
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00193362
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99478289
44Axon guidance_Homo sapiens_hsa043600.98615699
45ErbB signaling pathway_Homo sapiens_hsa040120.98039764
46Dorso-ventral axis formation_Homo sapiens_hsa043200.95901290
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92571309
48Melanogenesis_Homo sapiens_hsa049160.92109584
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.88799005
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85699562
51Pancreatic secretion_Homo sapiens_hsa049720.84221436
52Cardiac muscle contraction_Homo sapiens_hsa042600.81360468
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.80003118
54Type I diabetes mellitus_Homo sapiens_hsa049400.78397040
55Choline metabolism in cancer_Homo sapiens_hsa052310.75503769
56Thyroid hormone synthesis_Homo sapiens_hsa049180.74663687
57Oocyte meiosis_Homo sapiens_hsa041140.74416393
58MAPK signaling pathway_Homo sapiens_hsa040100.74216680
59Osteoclast differentiation_Homo sapiens_hsa043800.67857389
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67213582
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.65361506
62Prolactin signaling pathway_Homo sapiens_hsa049170.63899174
63Dilated cardiomyopathy_Homo sapiens_hsa054140.63816073
64African trypanosomiasis_Homo sapiens_hsa051430.63706428
65VEGF signaling pathway_Homo sapiens_hsa043700.62943104
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62311566
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58722214
68B cell receptor signaling pathway_Homo sapiens_hsa046620.57745774
69Ras signaling pathway_Homo sapiens_hsa040140.57551532
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.54728129
71Phagosome_Homo sapiens_hsa041450.52454776
72Glucagon signaling pathway_Homo sapiens_hsa049220.50834546
73Rap1 signaling pathway_Homo sapiens_hsa040150.50425681
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50271200
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50064059
76Rheumatoid arthritis_Homo sapiens_hsa053230.49890913
77Circadian rhythm_Homo sapiens_hsa047100.48880924
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48718541
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48173905
80Chemokine signaling pathway_Homo sapiens_hsa040620.48155292
81T cell receptor signaling pathway_Homo sapiens_hsa046600.48033410
82HIF-1 signaling pathway_Homo sapiens_hsa040660.47838502
83Fatty acid biosynthesis_Homo sapiens_hsa000610.47480717
84* Inositol phosphate metabolism_Homo sapiens_hsa005620.46282441
85Platelet activation_Homo sapiens_hsa046110.45565487
86Nitrogen metabolism_Homo sapiens_hsa009100.45555706
87Endocytosis_Homo sapiens_hsa041440.45362727
88mTOR signaling pathway_Homo sapiens_hsa041500.44041893
89Prion diseases_Homo sapiens_hsa050200.43864083
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42836740
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42187938
92FoxO signaling pathway_Homo sapiens_hsa040680.41017262
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40072714
94Alcoholism_Homo sapiens_hsa050340.39982572
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39882812
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39257635
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38976437
98Regulation of autophagy_Homo sapiens_hsa041400.38780281
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38686720
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37862367
101Amoebiasis_Homo sapiens_hsa051460.36419858
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36213479
103Alzheimers disease_Homo sapiens_hsa050100.35376273
104Non-small cell lung cancer_Homo sapiens_hsa052230.34836320
105Ovarian steroidogenesis_Homo sapiens_hsa049130.34674944
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34484943
107Bile secretion_Homo sapiens_hsa049760.34090686
108Renal cell carcinoma_Homo sapiens_hsa052110.33350923
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33262192
110Tuberculosis_Homo sapiens_hsa051520.30841758
111Insulin signaling pathway_Homo sapiens_hsa049100.30736454
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30350411
113Wnt signaling pathway_Homo sapiens_hsa043100.30337853
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29416895
115Endometrial cancer_Homo sapiens_hsa052130.28735035
116Salmonella infection_Homo sapiens_hsa051320.28384297

Most similar genes based on co-expression Upload to Enrichr

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