SYNJ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)4.70119005
2skin morphogenesis (GO:0043589)4.46563382
3synaptic vesicle maturation (GO:0016188)3.92052174
4chondrocyte proliferation (GO:0035988)3.78620561
5central nervous system myelination (GO:0022010)3.70567060
6axon ensheathment in central nervous system (GO:0032291)3.70567060
7retina vasculature morphogenesis in camera-type eye (GO:0061299)3.64803999
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55667199
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.54847096
10regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54147497
11actin filament depolymerization (GO:0030042)3.39290853
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.34395676
13glutamate secretion (GO:0014047)3.31426667
14sodium ion export (GO:0071436)3.29017339
15regulation of plasminogen activation (GO:0010755)3.28834009
16synaptic vesicle exocytosis (GO:0016079)3.28565690
17substrate-dependent cell migration (GO:0006929)3.25026810
18neuronal action potential propagation (GO:0019227)3.24537191
19negative regulation of fibrinolysis (GO:0051918)3.23333429
20COPII vesicle coating (GO:0048208)3.23309727
21COPI coating of Golgi vesicle (GO:0048205)3.22376179
22Golgi transport vesicle coating (GO:0048200)3.22376179
23plasma membrane repair (GO:0001778)3.19119248
24potassium ion import (GO:0010107)3.18355606
25membrane tubulation (GO:0097320)3.17996483
26mesodermal cell differentiation (GO:0048333)3.15334973
27regulation of synaptic vesicle exocytosis (GO:2000300)3.14521876
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14102394
29response to gravity (GO:0009629)3.13656662
30negative regulation of fatty acid transport (GO:2000192)3.10540536
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08138887
32creatine metabolic process (GO:0006600)3.08051715
33endodermal cell differentiation (GO:0035987)3.06225062
34cellular potassium ion homeostasis (GO:0030007)3.03621580
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01601920
36positive regulation of extracellular matrix organization (GO:1903055)3.01484374
37locomotory exploration behavior (GO:0035641)3.01132868
38vocalization behavior (GO:0071625)3.00960859
39L-amino acid import (GO:0043092)3.00896755
40regulation of voltage-gated calcium channel activity (GO:1901385)3.00728448
41wound healing, spreading of epidermal cells (GO:0035313)3.00027103
42negative regulation of potassium ion transmembrane transport (GO:1901380)2.98939183
43protein localization to endosome (GO:0036010)2.98659546
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.98658533
45regulation of cell communication by electrical coupling (GO:0010649)2.96891621
46cell-substrate junction assembly (GO:0007044)2.94402713
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91770581
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91052065
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90278087
50negative regulation of protein localization to cell surface (GO:2000009)2.87949734
51protein retention in ER lumen (GO:0006621)2.85232596
52regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84275612
53regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.84003102
54endocardial cushion development (GO:0003197)2.83450566
55cytoskeletal anchoring at plasma membrane (GO:0007016)2.83270041
56regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81278628
57regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.81156300
58ensheathment of neurons (GO:0007272)2.80986472
59axon ensheathment (GO:0008366)2.80986472
60myelination (GO:0042552)2.80044144
61macroautophagy (GO:0016236)2.79503665
62hypotonic response (GO:0006971)2.79394057
63regulation of calcium ion transmembrane transport (GO:1903169)2.77209979
64regulation of calcium ion transmembrane transporter activity (GO:1901019)2.77209979
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77136255
66cardiac myofibril assembly (GO:0055003)2.76273459
67hemidesmosome assembly (GO:0031581)2.75436968
68positive regulation of fibroblast migration (GO:0010763)2.75289783
69collagen fibril organization (GO:0030199)2.74144872
70positive regulation of blood vessel endothelial cell migration (GO:0043536)2.73622016
71positive regulation of osteoblast proliferation (GO:0033690)2.71017501
72cell migration involved in sprouting angiogenesis (GO:0002042)2.70240698
73regulation of synaptic vesicle transport (GO:1902803)2.69649728
74regulation of glutamate receptor signaling pathway (GO:1900449)2.69370178
75regulation of fibrinolysis (GO:0051917)2.69116816
76substrate adhesion-dependent cell spreading (GO:0034446)2.67996652
77cell communication involved in cardiac conduction (GO:0086065)2.67802676
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.67793908
79vesicle coating (GO:0006901)2.67634486
80regulation of synapse structural plasticity (GO:0051823)2.67084529
81endothelial cell morphogenesis (GO:0001886)2.63537226
82membrane depolarization during action potential (GO:0086010)2.63171325
83sarcomere organization (GO:0045214)2.63128480
84protein carboxylation (GO:0018214)2.62922451
85peptidyl-glutamic acid carboxylation (GO:0017187)2.62922451
86regulation of actin filament-based movement (GO:1903115)2.62486491
87myofibril assembly (GO:0030239)2.62483279
88sarcoplasmic reticulum calcium ion transport (GO:0070296)2.62273722
89positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.61424109
90cell communication by electrical coupling (GO:0010644)2.61392738
91potassium ion homeostasis (GO:0055075)2.60913832
92response to hepatocyte growth factor (GO:0035728)2.56535422
93cellular response to hepatocyte growth factor stimulus (GO:0035729)2.56535422
94desmosome organization (GO:0002934)2.56511622
95basement membrane organization (GO:0071711)2.55547284
96regulation of ARF protein signal transduction (GO:0032012)2.55366128
97nerve growth factor signaling pathway (GO:0038180)2.55073118
98endocytic recycling (GO:0032456)2.54969403
99protein hydroxylation (GO:0018126)2.54933098
100regulation of relaxation of muscle (GO:1901077)2.54803337
101regulation of cholesterol homeostasis (GO:2000188)2.54576172
102regulation of membrane repolarization (GO:0060306)2.53593417
103cardiac conduction (GO:0061337)2.52397801
104glomerular visceral epithelial cell development (GO:0072015)2.51020030
105sequestering of extracellular ligand from receptor (GO:0035581)2.49821586
106regulation of cardiac muscle cell contraction (GO:0086004)2.49504466
107regulation of transforming growth factor beta1 production (GO:0032908)2.49417905
108focal adhesion assembly (GO:0048041)2.49357084
109cell-substrate adherens junction assembly (GO:0007045)2.49357084
110glutamate receptor signaling pathway (GO:0007215)2.48105128
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46769917
112cerebellar granule cell differentiation (GO:0021707)2.44232354
113sprouting angiogenesis (GO:0002040)2.44134852
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.43103157
115adherens junction assembly (GO:0034333)2.42826589
116negative regulation of dendrite morphogenesis (GO:0050774)2.42131097
117peptidyl-tyrosine autophosphorylation (GO:0038083)2.41373861
118detection of calcium ion (GO:0005513)2.41275295
119cell volume homeostasis (GO:0006884)2.40922784
120positive regulation of potassium ion transport (GO:0043268)2.40911918
121blood vessel maturation (GO:0001955)2.40450942
122pericardium development (GO:0060039)2.39592617
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39422545
124protein localization to synapse (GO:0035418)2.38836613
125insulin-like growth factor receptor signaling pathway (GO:0048009)2.38467588
126ventricular cardiac muscle cell action potential (GO:0086005)2.38351834
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37688685
128regulation of cation channel activity (GO:2001257)2.37129324
129regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36736502
130activation of protein kinase A activity (GO:0034199)2.36509488
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36025916
132cellular response to vitamin D (GO:0071305)2.35830157
133long-chain fatty acid biosynthetic process (GO:0042759)2.34341739
134cellular response to epinephrine stimulus (GO:0071872)2.34168272
135synaptic transmission, glutamatergic (GO:0035249)2.34130068
136positive regulation of endothelial cell migration (GO:0010595)2.34095965
137glycine transport (GO:0015816)2.33996994
138neuromuscular junction development (GO:0007528)2.33830240
139asymmetric protein localization (GO:0008105)2.33596284
140regulation of neuronal synaptic plasticity (GO:0048168)2.33553144
141regulation of extracellular matrix disassembly (GO:0010715)2.32741549
142relaxation of cardiac muscle (GO:0055119)2.32614979
143regulation of heart rate by cardiac conduction (GO:0086091)2.31555490
144lymphangiogenesis (GO:0001946)2.31418352
145peptidyl-proline hydroxylation (GO:0019511)2.31391291
146positive regulation of epithelial cell migration (GO:0010634)2.31243756
147positive regulation of muscle hypertrophy (GO:0014742)2.30007941
148positive regulation of cardiac muscle hypertrophy (GO:0010613)2.30007941
149regulation of dendritic spine morphogenesis (GO:0061001)2.29412877
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.28392888
151regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.28242936
152cellular zinc ion homeostasis (GO:0006882)2.27931612
153regulation of postsynaptic membrane potential (GO:0060078)2.27423275
154negative regulation of inclusion body assembly (GO:0090084)2.27275987
155regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.26931009
156vesicle transport along microtubule (GO:0047496)2.26797443
157myelin maintenance (GO:0043217)2.26795879
158protein targeting to Golgi (GO:0000042)2.26740052
159membrane raft organization (GO:0031579)2.26320032
160cardiac muscle contraction (GO:0060048)2.26214425
161cellular response to vitamin (GO:0071295)2.26137128
162negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.26102120
163Golgi to endosome transport (GO:0006895)2.25438971
164stress fiber assembly (GO:0043149)2.25047880
165positive regulation of potassium ion transmembrane transport (GO:1901381)2.24842957
166multicellular organismal signaling (GO:0035637)2.23984764
167synaptic vesicle endocytosis (GO:0048488)2.23842644
168cortical actin cytoskeleton organization (GO:0030866)2.23498381
169response to epinephrine (GO:0071871)2.23430413
170activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.22659711
171regulation of dendritic spine development (GO:0060998)2.22490149
172membrane depolarization (GO:0051899)2.22482249
173regulation of type B pancreatic cell apoptotic process (GO:2000674)2.21859211
174neuron-neuron synaptic transmission (GO:0007270)2.21836105
175negative regulation of sodium ion transport (GO:0010766)2.18778675
176blood vessel endothelial cell migration (GO:0043534)2.17744138
177inositol phosphate-mediated signaling (GO:0048016)2.17714592
178endothelial cell proliferation (GO:0001935)2.17247040
179regulation of early endosome to late endosome transport (GO:2000641)2.16757699
180smooth muscle tissue development (GO:0048745)2.16429468
181semaphorin-plexin signaling pathway (GO:0071526)2.15827240
182intestinal cholesterol absorption (GO:0030299)2.15381361
183positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.14963516
184activation of Rac GTPase activity (GO:0032863)2.14930810
185regulation of transforming growth factor beta2 production (GO:0032909)2.14427807
186cytoskeleton-dependent cytokinesis (GO:0061640)2.14229014
187platelet degranulation (GO:0002576)2.14215322
188embryonic retina morphogenesis in camera-type eye (GO:0060059)2.13149628
189SMAD protein complex assembly (GO:0007183)2.12196781
190regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.11799148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.19322461
2GBX2_23144817_ChIP-Seq_PC3_Human2.63742859
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55961393
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52438337
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.49968060
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.43901509
7* DROSHA_22980978_ChIP-Seq_HELA_Human2.43766883
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35818591
9* BRD4_25478319_ChIP-Seq_HGPS_Human2.35196588
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22781201
11* CJUN_26792858_Chip-Seq_BT549_Human2.20282624
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14730011
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14595768
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.13036045
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99440935
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94575268
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92214801
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92214801
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87997985
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.87509295
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85834257
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83143172
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82742863
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82742863
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81313232
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80043505
27JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79534329
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74428996
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.73451804
30* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72641478
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70831641
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.68840627
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67632518
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67369314
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65612087
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64268249
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64155403
38CLOCK_20551151_ChIP-Seq_293T_Human1.64061001
39JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64054234
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.61004372
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.55749641
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52008383
43* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51918320
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51656530
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.51544430
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47427593
47AR_21572438_ChIP-Seq_LNCaP_Human1.44479038
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44170816
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42485177
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.39984647
51* TP53_23651856_ChIP-Seq_MEFs_Mouse1.39758691
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38307691
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37313420
54* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37302459
55REST_21632747_ChIP-Seq_MESCs_Mouse1.36717697
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.36521409
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35379383
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35376288
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34888439
60TP53_22127205_ChIP-Seq_IMR90_Human1.34573798
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.33756303
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33559519
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32671110
64* AHR_22903824_ChIP-Seq_MCF-7_Human1.32045421
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30206775
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29207818
67SMAD4_21799915_ChIP-Seq_A2780_Human1.27800938
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26724719
69TP53_16413492_ChIP-PET_HCT116_Human1.26027105
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24987183
71* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23484292
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.23071474
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22791046
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22413964
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22006274
76* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21746141
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21018090
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18917636
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18063971
80ATF3_27146783_Chip-Seq_COLON_Human1.14817099
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.14753601
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14681234
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14263308
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.13881455
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13847099
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13751286
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.13655307
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.13180283
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12856735
90* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11865026
91* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11865026
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11557899
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.11254488
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.11201940
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10951472
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10601175
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10347186
98SOX2_20726797_ChIP-Seq_SW620_Human1.10010951
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.09698546
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08987634
101SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08874557
102TBX20_22080862_ChIP-Seq_HEART_Mouse1.08584373
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.08584373
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07976827
105TET1_21490601_ChIP-Seq_MESCs_Mouse1.07836932
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.07179116
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.06136098
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05673445
109* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05007720
110STAT3_23295773_ChIP-Seq_U87_Human1.04854951
111* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04297764
112SMAD3_21741376_ChIP-Seq_HESCs_Human1.03778773
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01863903
114* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01601859
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00252874
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00145454
117TCF4_23295773_ChIP-Seq_U87_Human0.99979453
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99660234
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99300090
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.98457819
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97755084
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97242906
123AR_25329375_ChIP-Seq_VCAP_Human0.97193154
124* TP63_23658742_ChIP-Seq_EP156T_Human0.97182331
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.96174556
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95052482
127TP53_18474530_ChIP-ChIP_U2OS_Human0.94928727
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94916165
129* KDM2B_26808549_Chip-Seq_K562_Human0.94423726
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94366752
131* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93945236
132AR_19668381_ChIP-Seq_PC3_Human0.93414468
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.93345228
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93332316
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92873022
136* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92737326
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92499285
138ER_23166858_ChIP-Seq_MCF-7_Human0.92456935
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92155805
140TAF15_26573619_Chip-Seq_HEK293_Human0.91633166
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91416650
142* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91257970
143RXR_22158963_ChIP-Seq_LIVER_Mouse0.91219970
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.90947565
145RXR_22108803_ChIP-Seq_LS180_Human0.90940081
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.89749895
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89267009
148RING1B_27294783_Chip-Seq_ESCs_Mouse0.88738147
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88393774
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87882460
151RACK7_27058665_Chip-Seq_MCF-7_Human0.87294777
152* GATA2_21666600_ChIP-Seq_HMVEC_Human0.86162180
153P300_19829295_ChIP-Seq_ESCs_Human0.85923358
154* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85141464
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85024978
156SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84157592
157* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83095759
158* PRDM14_20953172_ChIP-Seq_ESCs_Human0.81422726
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81172127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.65434780
2MP0010368_abnormal_lymphatic_system3.75568991
3MP0003705_abnormal_hypodermis_morpholog3.60081389
4MP0004272_abnormal_basement_membrane3.37605627
5MP0003880_abnormal_central_pattern3.29187190
6MP0003566_abnormal_cell_adhesion3.19336037
7MP0000751_myopathy3.15357545
8MP0004270_analgesia2.91896317
9MP0002837_dystrophic_cardiac_calcinosis2.70824980
10MP0003635_abnormal_synaptic_transmissio2.55135680
11MP0003279_aneurysm2.54824846
12MP0000920_abnormal_myelination2.41821523
13MP0001958_emphysema2.39681570
14MP0004084_abnormal_cardiac_muscle2.37399007
15MP0004510_myositis2.35067611
16MP0004036_abnormal_muscle_relaxation2.32620715
17MP0005257_abnormal_intraocular_pressure2.32310097
18MP0000749_muscle_degeneration2.30138915
19MP0010352_gastrointestinal_tract_polyps2.26734218
20MP0002064_seizures2.25384747
21MP0009046_muscle_twitch2.21866015
22MP0003329_amyloid_beta_deposits2.15261878
23MP0002877_abnormal_melanocyte_morpholog2.13899528
24MP0009745_abnormal_behavioral_response2.07402250
25MP0005023_abnormal_wound_healing2.05352156
26MP0009780_abnormal_chondrocyte_physiolo2.05267271
27MP0006054_spinal_hemorrhage2.03761122
28MP0005623_abnormal_meninges_morphology2.02570982
29MP0002272_abnormal_nervous_system1.97905331
30MP0004145_abnormal_muscle_electrophysio1.90697310
31MP0004215_abnormal_myocardial_fiber1.89075451
32MP0001486_abnormal_startle_reflex1.86934653
33MP0002063_abnormal_learning/memory/cond1.82499515
34MP0001346_abnormal_lacrimal_gland1.73819604
35MP0003690_abnormal_glial_cell1.73176261
36MP0008569_lethality_at_weaning1.71688688
37MP0002734_abnormal_mechanical_nocicepti1.69405171
38MP0009384_cardiac_valve_regurgitation1.68983985
39MP0000767_abnormal_smooth_muscle1.68698254
40MP0003950_abnormal_plasma_membrane1.67763701
41MP0004087_abnormal_muscle_fiber1.67630825
42MP0004130_abnormal_muscle_cell1.67077258
43MP0005330_cardiomyopathy1.66323060
44MP0000747_muscle_weakness1.60354750
45MP0003879_abnormal_hair_cell1.58940890
46MP0002896_abnormal_bone_mineralization1.58126086
47MP0003646_muscle_fatigue1.58046430
48MP0009840_abnormal_foam_cell1.57209043
49MP0005275_abnormal_skin_tensile1.56968291
50MP0001348_abnormal_lacrimal_gland1.56836795
51MP0003045_fibrosis1.52477869
52MP0002572_abnormal_emotion/affect_behav1.50306120
53MP0005620_abnormal_muscle_contractility1.48474495
54MP0002972_abnormal_cardiac_muscle1.47864770
55MP0004484_altered_response_of1.47304282
56MP0005409_darkened_coat_color1.38440269
57MP0008438_abnormal_cutaneous_collagen1.37545742
58MP0008004_abnormal_stomach_pH1.37530415
59MP0001968_abnormal_touch/_nociception1.36464345
60MP0000604_amyloidosis1.36291046
61MP0003283_abnormal_digestive_organ1.36046503
62MP0002254_reproductive_system_inflammat1.35609674
63MP0003868_abnormal_feces_composition1.34469659
64MP0005503_abnormal_tendon_morphology1.34361130
65MP0002735_abnormal_chemical_nociception1.34288657
66MP0001879_abnormal_lymphatic_vessel1.33901762
67MP0003633_abnormal_nervous_system1.33209301
68MP0001440_abnormal_grooming_behavior1.33195368
69MP0001501_abnormal_sleep_pattern1.32223874
70MP0002106_abnormal_muscle_physiology1.31066954
71MP0003137_abnormal_impulse_conducting1.30515557
72MP0005410_abnormal_fertilization1.26852329
73MP0008775_abnormal_heart_ventricle1.25074882
74MP0002060_abnormal_skin_morphology1.25048419
75MP0001849_ear_inflammation1.24910240
76MP0004085_abnormal_heartbeat1.23852968
77MP0004185_abnormal_adipocyte_glucose1.20585830
78MP0001915_intracranial_hemorrhage1.19847414
79MP0004885_abnormal_endolymph1.19265656
80MP0000759_abnormal_skeletal_muscle1.18326312
81MP0002295_abnormal_pulmonary_circulatio1.18302802
82MP0005369_muscle_phenotype1.16193232
83MP0005310_abnormal_salivary_gland1.16066682
84MP0003075_altered_response_to1.15873071
85MP0003634_abnormal_glial_cell1.15839160
86MP0005595_abnormal_vascular_smooth1.15393044
87MP0004134_abnormal_chest_morphology1.14911314
88MP0001970_abnormal_pain_threshold1.14489976
89MP0004742_abnormal_vestibular_system1.13750382
90MP0002067_abnormal_sensory_capabilities1.12781797
91MP0002089_abnormal_postnatal_growth/wei1.12312188
92MP0003191_abnormal_cellular_cholesterol1.11503669
93MP0000534_abnormal_ureter_morphology1.10696318
94MP0010386_abnormal_urinary_bladder1.10341274
95MP0001299_abnormal_eye_distance/1.10121342
96MP0002736_abnormal_nociception_after1.09610593
97MP0003631_nervous_system_phenotype1.08729174
98MP0002269_muscular_atrophy1.07646954
99MP0001485_abnormal_pinna_reflex1.07218269
100MP0002909_abnormal_adrenal_gland1.07163474
101MP0005423_abnormal_somatic_nervous1.04147907
102MP0002168_other_aberrant_phenotype1.03735025
103MP0001243_abnormal_dermal_layer1.03343113
104MP0000733_abnormal_muscle_development1.03198397
105MP0004858_abnormal_nervous_system1.02045064
106MP0000003_abnormal_adipose_tissue1.00098418
107MP0005165_increased_susceptibility_to0.98101009
108MP0004233_abnormal_muscle_weight0.97575647
109MP0002066_abnormal_motor_capabilities/c0.96859640
110MP0005360_urolithiasis0.96651776
111MP0002229_neurodegeneration0.96479157
112MP0004924_abnormal_behavior0.95560416
113MP0005386_behavior/neurological_phenoty0.95560416
114MP0002090_abnormal_vision0.94923848
115MP0001502_abnormal_circadian_rhythm0.94644652
116MP0005171_absent_coat_pigmentation0.94081554
117MP0000750_abnormal_muscle_regeneration0.92845790
118MP0005076_abnormal_cell_differentiation0.92581623
119MP0002933_joint_inflammation0.91041034
120MP0003123_paternal_imprinting0.90995335
121MP0000013_abnormal_adipose_tissue0.90923147
122MP0002822_catalepsy0.90800887
123MP0005508_abnormal_skeleton_morphology0.90599757
124MP0006138_congestive_heart_failure0.89697428
125MP0008874_decreased_physiological_sensi0.89149305
126MP0004811_abnormal_neuron_physiology0.88750792
127MP0003300_gastrointestinal_ulcer0.88640819
128MP0002925_abnormal_cardiovascular_devel0.88460239
129MP0010630_abnormal_cardiac_muscle0.88078458
130MP0002128_abnormal_blood_circulation0.87991687
131MP0002733_abnormal_thermal_nociception0.87532664
132MP0003091_abnormal_cell_migration0.87305506
133MP0000569_abnormal_digit_pigmentation0.87061234
134MP0002108_abnormal_muscle_morphology0.86932683
135MP0003172_abnormal_lysosome_physiology0.85474019
136MP0002882_abnormal_neuron_morphology0.85366924
137MP0000778_abnormal_nervous_system0.84905815
138MP0001544_abnormal_cardiovascular_syste0.84067640
139MP0005385_cardiovascular_system_phenoty0.84067640
140MP0005375_adipose_tissue_phenotype0.84039282
141MP0003632_abnormal_nervous_system0.83066113
142MP0005645_abnormal_hypothalamus_physiol0.82542004
143MP0001542_abnormal_bone_strength0.82456154
144MP0010678_abnormal_skin_adnexa0.82301007
145MP0001614_abnormal_blood_vessel0.81870483
146MP0005164_abnormal_response_to0.79856498
147MP0000428_abnormal_craniofacial_morphol0.77534835
148MP0001270_distended_abdomen0.74749664
149MP0005621_abnormal_cell_physiology0.74503393
150MP0003252_abnormal_bile_duct0.73763631
151MP0003943_abnormal_hepatobiliary_system0.71049364
152MP0003385_abnormal_body_wall0.69979417
153MP0000762_abnormal_tongue_morphology0.67458073
154MP0000163_abnormal_cartilage_morphology0.66565864
155MP0000462_abnormal_digestive_system0.64362074
156MP0003828_pulmonary_edema0.64357082
157MP0003942_abnormal_urinary_system0.62274971
158MP0003941_abnormal_skin_development0.60526535
159MP0010329_abnormal_lipoprotein_level0.58562497
160MP0003115_abnormal_respiratory_system0.57716994
161MP0003935_abnormal_craniofacial_develop0.56777877
162MP0002086_abnormal_extraembryonic_tissu0.55730970

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.89621194
2Premature rupture of membranes (HP:0001788)5.77632188
3Focal motor seizures (HP:0011153)4.29497981
4Hyporeflexia of lower limbs (HP:0002600)4.28132718
5Aortic dissection (HP:0002647)4.09428996
6Vascular tortuosity (HP:0004948)4.08186263
7Sudden death (HP:0001699)3.99909290
8Muscle hypertrophy of the lower extremities (HP:0008968)3.76953869
9Muscle fiber splitting (HP:0003555)3.70565561
10Exercise-induced myalgia (HP:0003738)3.66042715
11Calf muscle hypertrophy (HP:0008981)3.65567732
12Myokymia (HP:0002411)3.53235045
13Aortic aneurysm (HP:0004942)3.52832676
14Exercise-induced muscle cramps (HP:0003710)3.37398850
15Neurofibrillary tangles (HP:0002185)3.37051047
16Cervical subluxation (HP:0003308)3.27143871
17Difficulty running (HP:0009046)3.25421706
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.21663209
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.21663209
20Abnormality of the calf musculature (HP:0001430)3.21517907
21Atrial fibrillation (HP:0005110)3.18570715
22Right ventricular cardiomyopathy (HP:0011663)3.17694035
23Cardiovascular calcification (HP:0011915)3.16054502
24Supranuclear gaze palsy (HP:0000605)3.16051322
25Bundle branch block (HP:0011710)3.15907371
26Focal seizures (HP:0007359)3.14777502
27Mitral stenosis (HP:0001718)3.11851064
28Syncope (HP:0001279)3.09135619
29EMG: myopathic abnormalities (HP:0003458)3.06425935
30Ventricular fibrillation (HP:0001663)3.03767113
31Ankle contracture (HP:0006466)3.00646106
32Wormian bones (HP:0002645)2.99187649
33Spondylolisthesis (HP:0003302)2.97131661
34Shallow orbits (HP:0000586)2.93430834
35Cerebral inclusion bodies (HP:0100314)2.92656581
36Primary atrial arrhythmia (HP:0001692)2.92310828
37Prolonged QT interval (HP:0001657)2.90816079
38Dysmetria (HP:0001310)2.89597719
39Lower limb amyotrophy (HP:0007210)2.87145912
40Onion bulb formation (HP:0003383)2.83228466
41Cerebral aneurysm (HP:0004944)2.78875460
42Epileptic encephalopathy (HP:0200134)2.77370331
43Ankle clonus (HP:0011448)2.73544703
44Atrophic scars (HP:0001075)2.72645947
45Distal lower limb amyotrophy (HP:0008944)2.72428092
46Deep venous thrombosis (HP:0002625)2.71572312
47Supraventricular tachycardia (HP:0004755)2.70954967
48Spinal rigidity (HP:0003306)2.70128302
49Short nail (HP:0001799)2.69616513
50Ventricular tachycardia (HP:0004756)2.69600402
51Atonic seizures (HP:0010819)2.68545289
52Vascular calcification (HP:0004934)2.65984354
53Supraventricular arrhythmia (HP:0005115)2.65049039
54Vertebral compression fractures (HP:0002953)2.64313792
55Fragile skin (HP:0001030)2.62406285
56Ventricular arrhythmia (HP:0004308)2.60085086
57Insidious onset (HP:0003587)2.57095339
58Termporal pattern (HP:0011008)2.57095339
59Abnormality of the corticospinal tract (HP:0002492)2.51563820
60Abnormality of dentin (HP:0010299)2.51436579
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.50886300
62Osteolytic defects of the hand bones (HP:0009699)2.50886300
63Increased variability in muscle fiber diameter (HP:0003557)2.50768783
64Intention tremor (HP:0002080)2.46892840
65Action tremor (HP:0002345)2.46459948
66Distal upper limb amyotrophy (HP:0007149)2.46166861
67Upper limb amyotrophy (HP:0009129)2.46166861
68Type 1 muscle fiber predominance (HP:0003803)2.43394590
69Broad face (HP:0000283)2.42492133
70Bladder diverticulum (HP:0000015)2.42080639
71Abnormality of carpal bone ossification (HP:0006257)2.40934049
72Spastic gait (HP:0002064)2.40378792
73Gaze-evoked nystagmus (HP:0000640)2.40175854
74Scapular winging (HP:0003691)2.37625702
75Dysmetric saccades (HP:0000641)2.34892181
76Urinary bladder sphincter dysfunction (HP:0002839)2.33373443
77Urinary urgency (HP:0000012)2.31090898
78Abnormality of the acetabulum (HP:0003170)2.30683071
79Neonatal short-limb short stature (HP:0008921)2.30492651
80Soft skin (HP:0000977)2.30210837
81Visual hallucinations (HP:0002367)2.29895022
82Mitral regurgitation (HP:0001653)2.28781385
83Overgrowth (HP:0001548)2.28480384
84Gowers sign (HP:0003391)2.27911657
85Follicular hyperkeratosis (HP:0007502)2.24471605
86Increased connective tissue (HP:0009025)2.23976744
87Absence seizures (HP:0002121)2.23300689
88Lower limb muscle weakness (HP:0007340)2.22944091
89Aneurysm (HP:0002617)2.22930355
90Blue sclerae (HP:0000592)2.21748548
91Muscle fiber inclusion bodies (HP:0100299)2.21726337
92Impaired vibration sensation in the lower limbs (HP:0002166)2.21605531
93Rapidly progressive (HP:0003678)2.20160056
94Ulnar bowing (HP:0003031)2.18622975
95Postural instability (HP:0002172)2.18588160
96Mitral valve prolapse (HP:0001634)2.18492281
97Dysdiadochokinesis (HP:0002075)2.18065494
98Scanning speech (HP:0002168)2.16934222
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.16528206
100Abnormality of skeletal muscle fiber size (HP:0012084)2.16273372
101Abnormal ossification of hand bones (HP:0005921)2.15920634
102Pheochromocytoma (HP:0002666)2.12619504
103Hand muscle atrophy (HP:0009130)2.11760506
104Coxa vara (HP:0002812)2.11332382
105Spinal cord compression (HP:0002176)2.10510444
106Difficulty climbing stairs (HP:0003551)2.09998306
107Abnormal EKG (HP:0003115)2.09615647
108Dialeptic seizures (HP:0011146)2.08926578
109Foot dorsiflexor weakness (HP:0009027)2.08437332
110Sensory axonal neuropathy (HP:0003390)2.08388061
111Aortic regurgitation (HP:0001659)2.07747998
112Progressive cerebellar ataxia (HP:0002073)2.07398834
113Myotonia (HP:0002486)2.07140803
114Menorrhagia (HP:0000132)2.05235133
115Generalized tonic-clonic seizures (HP:0002069)2.03911811
116Dilatation of the ascending aorta (HP:0005111)2.02124481
117Asymmetric septal hypertrophy (HP:0001670)1.99866877
118Aplasia involving bones of the extremities (HP:0009825)1.99287798
119Aplasia involving bones of the upper limbs (HP:0009823)1.99287798
120Aplasia of the phalanges of the hand (HP:0009802)1.99287798
121Hyperextensible skin (HP:0000974)1.98024869
122Bradycardia (HP:0001662)1.97698647
123Joint laxity (HP:0001388)1.96981526
124Flat acetabular roof (HP:0003180)1.96079774
125Broad metatarsal (HP:0001783)1.95450638
126Arterial tortuosity (HP:0005116)1.93819142
127Lipoatrophy (HP:0100578)1.92661526
128Heart block (HP:0012722)1.92625400
129Abnormality of the foot musculature (HP:0001436)1.92585211
130Abnormal delivery (HP:0001787)1.90845705
131Abnormal hand bone ossification (HP:0010660)1.90834211
132Peritonitis (HP:0002586)1.90734904
133Delayed closure of the anterior fontanelle (HP:0001476)1.90623465
134Round ear (HP:0100830)1.90190294
135Hyperacusis (HP:0010780)1.89684722
136Abnormal atrioventricular conduction (HP:0005150)1.89533575
137Wrist flexion contracture (HP:0001239)1.89129352
138Depression (HP:0000716)1.87537292
139Glucose intolerance (HP:0000833)1.87489634
140Dilated cardiomyopathy (HP:0001644)1.87420575
141Myoglobinuria (HP:0002913)1.87404205
142Abnormality of oral frenula (HP:0000190)1.87323271
143Achilles tendon contracture (HP:0001771)1.87103880
144Renal duplication (HP:0000075)1.86674935
145Broad-based gait (HP:0002136)1.86394049
146Disproportionate tall stature (HP:0001519)1.85869916
147Frequent falls (HP:0002359)1.85593103
148Febrile seizures (HP:0002373)1.84898378
149Slow saccadic eye movements (HP:0000514)1.84758570
150Bowel diverticulosis (HP:0005222)1.84394294
151Subaortic stenosis (HP:0001682)1.84333930
152Abnormality of the left ventricular outflow tract (HP:0011103)1.84333930
153Akinesia (HP:0002304)1.84081857
154Truncal ataxia (HP:0002078)1.83430414
155Abnormality of saccadic eye movements (HP:0000570)1.81761055
156Hypoalphalipoproteinemia (HP:0003233)1.80534352
157Hypoplastic ischia (HP:0003175)1.80375725
158Abnormality of the Achilles tendon (HP:0005109)1.80175191
159Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80174222
160Axonal loss (HP:0003447)1.80129041
161Nemaline bodies (HP:0003798)1.79789784
162Peripheral hypomyelination (HP:0007182)1.78978975
163Flared iliac wings (HP:0002869)1.78367478
164Neck muscle weakness (HP:0000467)1.78354445
165Relative macrocephaly (HP:0004482)1.76742510
166Dislocated radial head (HP:0003083)1.76174042
167Insomnia (HP:0100785)1.76017327
168Long toe (HP:0010511)1.75945299
169Striae distensae (HP:0001065)1.75896507
170Elbow flexion contracture (HP:0002987)1.75657680
171Bronchomalacia (HP:0002780)1.75427770
172Obstructive sleep apnea (HP:0002870)1.75420822
173Mild short stature (HP:0003502)1.74180298
174Genu recurvatum (HP:0002816)1.73661800
175Tibial bowing (HP:0002982)1.73587989
176Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71822534
177Mildly elevated creatine phosphokinase (HP:0008180)1.71064105
178Bowing of the arm (HP:0006488)1.70847905
179Bowed forearm bones (HP:0003956)1.70847905
180Syringomyelia (HP:0003396)1.70478401
181Spinal cord lesions (HP:0100561)1.70478401
182Urinary glycosaminoglycan excretion (HP:0003541)1.69582976
183Mucopolysacchariduria (HP:0008155)1.69582976
184Protruding ear (HP:0000411)1.68526291
185Ovoid vertebral bodies (HP:0003300)1.67810073
186Asymmetry of the thorax (HP:0001555)1.67610209
187Abnormality of the common coagulation pathway (HP:0010990)1.67344189
188Neonatal death (HP:0003811)1.67334098
189Osteoarthritis (HP:0002758)1.66419946
190Abnormality of the nasal septum (HP:0000419)1.64920845
191Biconcave vertebral bodies (HP:0004586)1.64436430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.30129628
2EPHA23.04032570
3EPHA42.77861275
4TTN2.74486451
5TIE12.57005524
6MST1R2.39210514
7IRAK32.34784258
8OXSR12.30478240
9DAPK22.28589783
10PAK62.27096304
11AKT32.14471904
12CDK122.10737668
13DMPK2.07701054
14EPHB12.07686359
15PRKD31.95930417
16MAP3K91.91256309
17PRPF4B1.88934767
18NTRK31.82379527
19LATS21.81243368
20NTRK11.77440013
21FGFR41.70498791
22MAP3K41.68003985
23OBSCN1.66692640
24CDK191.66473646
25MAP3K131.61039395
26WNK11.59964413
27LMTK21.53964470
28RIPK41.53759081
29PHKG21.51645562
30PHKG11.51645562
31LATS11.50582081
32MAP3K71.43381511
33TGFBR21.41326298
34KSR21.40701865
35ERBB41.40578944
36PKN11.39022448
37TESK11.37974864
38PAK21.37582506
39PTK2B1.35275676
40FGFR31.34729847
41PDK31.29186616
42PDK41.29186616
43WNK41.27947083
44PAK31.23951855
45PRKCH1.18960602
46ROCK21.17986334
47CDK51.17005558
48CAMK2D1.16693768
49SCYL21.16616558
50MAP3K121.14540672
51CAMKK11.14452361
52RIPK11.12648402
53MTOR1.11243207
54TYRO31.09741815
55PAK41.07126170
56DDR21.05951893
57PDPK11.04256338
58PDK11.04013186
59ICK1.03765349
60PDK20.99333624
61STK38L0.98937238
62PRKG20.97988305
63FGFR20.97608757
64CAMK2B0.97088405
65TRIB30.96911179
66STK380.96573362
67MAP2K40.96382214
68MAPKAPK50.96333642
69NEK90.95940045
70EEF2K0.95850410
71CAMK2A0.95762307
72PRKD20.92867333
73CDK80.92707349
74TRPM70.90554679
75MINK10.89666315
76FER0.89564808
77SGK2230.88501359
78SGK4940.88501359
79BCR0.88176522
80CAMK1G0.85580333
81RET0.85038479
82MELK0.84559928
83MOS0.84352441
84ERN10.83742037
85DAPK30.83608762
86STK110.81791402
87MAPK110.80771832
88MAP3K20.80390615
89MET0.79586867
90FGR0.78984243
91CAMK10.77494455
92PIK3CA0.76618852
93CDC42BPA0.76272268
94PRKD10.75826154
95CAMK2G0.73812759
96MAPKAPK30.71916179
97MYLK0.70908046
98FGFR10.70616848
99UHMK10.70543125
100PRKCQ0.70332284
101PLK20.70007971
102JAK10.67580416
103CASK0.67080364
104PDGFRA0.66511616
105SGK10.65928358
106NEK60.65394588
107CAMK1D0.64603508
108MARK20.63063900
109PDGFRB0.62782464
110BMX0.62702908
111MAP2K70.62058873
112PRKCE0.61873499
113FYN0.61793906
114STK30.61721209
115PINK10.61608555
116MAP2K10.61486009
117NTRK20.60675846
118MAP3K10.59738989
119SIK20.57581430
120ROCK10.56688557
121FES0.56271431
122EIF2AK10.52030539
123BRSK10.51881880
124CDK150.51621959
125SIK10.51096716
126CDK140.49390883
127CDK180.47813997
128PKN20.47188860
129GRK50.46737197
130NME10.46291429
131SGK30.46211690
132CLK10.45938897
133RPS6KA20.44727184
134PTK20.44661220
135DAPK10.44423478
136BRD40.44267473
137MAPK120.44132634
138MAPK100.44064960
139CAMKK20.43304969
140LIMK10.41483167
141CDK90.40934544
142BMPR1B0.40367668
143NEK10.40218877
144PRKAA20.37557971
145ILK0.36168383
146PRKAA10.35847969

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.09130369
2Dilated cardiomyopathy_Homo sapiens_hsa054141.97320391
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.92664574
4Circadian entrainment_Homo sapiens_hsa047131.91454697
5Salivary secretion_Homo sapiens_hsa049701.86799132
6Nicotine addiction_Homo sapiens_hsa050331.81133769
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.79899483
8Gastric acid secretion_Homo sapiens_hsa049711.78605300
9Olfactory transduction_Homo sapiens_hsa047401.76937838
10Glutamatergic synapse_Homo sapiens_hsa047241.71082177
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70843461
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67775263
13Morphine addiction_Homo sapiens_hsa050321.67002976
14Long-term potentiation_Homo sapiens_hsa047201.66763913
15Adherens junction_Homo sapiens_hsa045201.66510798
16GABAergic synapse_Homo sapiens_hsa047271.65576887
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64955080
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53175640
19Amphetamine addiction_Homo sapiens_hsa050311.51965890
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51051572
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49559982
22Insulin secretion_Homo sapiens_hsa049111.48405620
23Cardiac muscle contraction_Homo sapiens_hsa042601.44844864
24Oxytocin signaling pathway_Homo sapiens_hsa049211.43611008
25Calcium signaling pathway_Homo sapiens_hsa040201.41903020
26Renin secretion_Homo sapiens_hsa049241.39703083
27Nitrogen metabolism_Homo sapiens_hsa009101.38257083
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35762601
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29268788
30Cholinergic synapse_Homo sapiens_hsa047251.28339865
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25482322
32Dopaminergic synapse_Homo sapiens_hsa047281.19240776
33Circadian rhythm_Homo sapiens_hsa047101.18908906
34Collecting duct acid secretion_Homo sapiens_hsa049661.16947704
35* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14972426
36Type II diabetes mellitus_Homo sapiens_hsa049301.14701051
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.14586120
38Hippo signaling pathway_Homo sapiens_hsa043901.14253186
39Complement and coagulation cascades_Homo sapiens_hsa046101.14116892
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12687393
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11932709
42GnRH signaling pathway_Homo sapiens_hsa049121.11102649
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10992679
44cAMP signaling pathway_Homo sapiens_hsa040241.10443360
45Dorso-ventral axis formation_Homo sapiens_hsa043201.08048449
46Bladder cancer_Homo sapiens_hsa052191.06992841
47Small cell lung cancer_Homo sapiens_hsa052221.05253160
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04235732
49TGF-beta signaling pathway_Homo sapiens_hsa043501.03999442
50Chronic myeloid leukemia_Homo sapiens_hsa052201.03205439
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01896042
52Long-term depression_Homo sapiens_hsa047301.01873864
53mTOR signaling pathway_Homo sapiens_hsa041501.00042042
54Serotonergic synapse_Homo sapiens_hsa047260.99600955
55MicroRNAs in cancer_Homo sapiens_hsa052060.98964309
56Pancreatic secretion_Homo sapiens_hsa049720.98051054
57Axon guidance_Homo sapiens_hsa043600.97734083
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97420947
59Vibrio cholerae infection_Homo sapiens_hsa051100.97164163
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96980610
61ErbB signaling pathway_Homo sapiens_hsa040120.93942762
62Sphingolipid metabolism_Homo sapiens_hsa006000.92953688
63Vitamin B6 metabolism_Homo sapiens_hsa007500.91509189
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90727166
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.89509402
66Gap junction_Homo sapiens_hsa045400.89267741
67Cocaine addiction_Homo sapiens_hsa050300.87542716
68Taste transduction_Homo sapiens_hsa047420.87291015
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86377735
70Estrogen signaling pathway_Homo sapiens_hsa049150.85721280
71Pancreatic cancer_Homo sapiens_hsa052120.84447651
72Bile secretion_Homo sapiens_hsa049760.84134027
73Protein digestion and absorption_Homo sapiens_hsa049740.84106130
74N-Glycan biosynthesis_Homo sapiens_hsa005100.83065605
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82841855
76Glioma_Homo sapiens_hsa052140.81956537
77Endocytosis_Homo sapiens_hsa041440.79363488
78Lysine degradation_Homo sapiens_hsa003100.79268887
79Prion diseases_Homo sapiens_hsa050200.79035319
80Renal cell carcinoma_Homo sapiens_hsa052110.77086763
81Other glycan degradation_Homo sapiens_hsa005110.76904357
82Focal adhesion_Homo sapiens_hsa045100.75961986
83MAPK signaling pathway_Homo sapiens_hsa040100.75116499
84VEGF signaling pathway_Homo sapiens_hsa043700.74504753
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.74460427
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.74325196
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73796662
88Amoebiasis_Homo sapiens_hsa051460.72950852
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72131331
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.69855549
91Non-small cell lung cancer_Homo sapiens_hsa052230.69854558
92Fatty acid elongation_Homo sapiens_hsa000620.68893261
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68815343
94Tight junction_Homo sapiens_hsa045300.68355876
95Melanoma_Homo sapiens_hsa052180.67638592
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66196259
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66170159
98Thyroid cancer_Homo sapiens_hsa052160.65946204
99Ras signaling pathway_Homo sapiens_hsa040140.65809900
100Rheumatoid arthritis_Homo sapiens_hsa053230.64485280
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.64478394
102ECM-receptor interaction_Homo sapiens_hsa045120.63955289
103ABC transporters_Homo sapiens_hsa020100.63718396
104Thyroid hormone synthesis_Homo sapiens_hsa049180.63664234
105Fatty acid biosynthesis_Homo sapiens_hsa000610.63373819
106Melanogenesis_Homo sapiens_hsa049160.61905859
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61659496
108* Inositol phosphate metabolism_Homo sapiens_hsa005620.59677338
109Endometrial cancer_Homo sapiens_hsa052130.58864289
110Rap1 signaling pathway_Homo sapiens_hsa040150.58657580
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57973556
112Glucagon signaling pathway_Homo sapiens_hsa049220.57328316
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.57086017
114Choline metabolism in cancer_Homo sapiens_hsa052310.53785172
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53266785
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52044898
117Chemokine signaling pathway_Homo sapiens_hsa040620.51881937
118Ether lipid metabolism_Homo sapiens_hsa005650.51494941
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.51366111
120Proteoglycans in cancer_Homo sapiens_hsa052050.51016489
121Salmonella infection_Homo sapiens_hsa051320.50638914
122Phagosome_Homo sapiens_hsa041450.50442893
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47558191
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46361618
125African trypanosomiasis_Homo sapiens_hsa051430.46129360
126Lysosome_Homo sapiens_hsa041420.45568768
127Osteoclast differentiation_Homo sapiens_hsa043800.44519251
128Platelet activation_Homo sapiens_hsa046110.42345808
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41915246
130Mineral absorption_Homo sapiens_hsa049780.41210138
131Ovarian steroidogenesis_Homo sapiens_hsa049130.40559320
132Propanoate metabolism_Homo sapiens_hsa006400.40368664
133Insulin resistance_Homo sapiens_hsa049310.39559874

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