SYNJ2BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)5.05843907
2doxorubicin metabolic process (GO:0044598)5.05843907
3daunorubicin metabolic process (GO:0044597)5.05843907
4cellular glucuronidation (GO:0052695)4.37757132
5glucuronate metabolic process (GO:0019585)4.20615193
6uronic acid metabolic process (GO:0006063)4.20615193
7water-soluble vitamin biosynthetic process (GO:0042364)4.11692153
8response to pheromone (GO:0019236)4.07706617
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95039382
10L-phenylalanine catabolic process (GO:0006559)3.95039382
11tryptophan metabolic process (GO:0006568)3.93039688
12tryptophan catabolic process (GO:0006569)3.89619334
13indole-containing compound catabolic process (GO:0042436)3.89619334
14indolalkylamine catabolic process (GO:0046218)3.89619334
15aromatic amino acid family catabolic process (GO:0009074)3.79290917
16signal peptide processing (GO:0006465)3.74894893
17prenylation (GO:0097354)3.67053106
18protein prenylation (GO:0018342)3.67053106
19L-phenylalanine metabolic process (GO:0006558)3.58649369
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.58649369
21positive regulation of glycolytic process (GO:0045821)3.54691711
22positive regulation of mitochondrial fission (GO:0090141)3.51334783
23phospholipid efflux (GO:0033700)3.46972993
24oxaloacetate metabolic process (GO:0006107)3.40514895
25aminoglycoside antibiotic metabolic process (GO:0030647)3.36748881
26urea metabolic process (GO:0019627)3.34341065
27urea cycle (GO:0000050)3.34341065
28bile acid biosynthetic process (GO:0006699)3.34205707
29regulation of hexokinase activity (GO:1903299)3.33431579
30regulation of glucokinase activity (GO:0033131)3.33431579
31kidney morphogenesis (GO:0060993)3.31764107
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.31542294
33amine catabolic process (GO:0009310)3.25994324
34cellular biogenic amine catabolic process (GO:0042402)3.25994324
35lipid particle organization (GO:0034389)3.23791366
36nucleotide transmembrane transport (GO:1901679)3.23055309
37aldehyde catabolic process (GO:0046185)3.20056006
38high-density lipoprotein particle remodeling (GO:0034375)3.18817648
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17258472
40indolalkylamine metabolic process (GO:0006586)3.15226221
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13647016
42valine metabolic process (GO:0006573)3.11104544
43cellular ketone body metabolic process (GO:0046950)3.08768442
44misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.08533602
45lactate metabolic process (GO:0006089)3.07653991
46kynurenine metabolic process (GO:0070189)3.07567456
47production of molecular mediator involved in inflammatory response (GO:0002532)3.07280663
48cytochrome complex assembly (GO:0017004)3.06658780
49ketone body metabolic process (GO:1902224)3.04382540
50tyrosine metabolic process (GO:0006570)3.02844968
51regulation of cholesterol esterification (GO:0010872)3.01682240
52benzene-containing compound metabolic process (GO:0042537)3.00909029
53heart contraction (GO:0060047)3.00634436
54heart process (GO:0003015)3.00634436
55NAD biosynthetic process (GO:0009435)2.99857754
56xenobiotic catabolic process (GO:0042178)2.98935904
57polyol catabolic process (GO:0046174)2.96752513
58diterpenoid biosynthetic process (GO:0016102)2.95751960
59intraciliary transport (GO:0042073)2.91655815
60definitive hemopoiesis (GO:0060216)2.91255862
61nitrogen cycle metabolic process (GO:0071941)2.90402633
62coenzyme catabolic process (GO:0009109)2.89260300
63inositol phosphate catabolic process (GO:0071545)2.89010832
64protein complex biogenesis (GO:0070271)2.86965894
65succinate metabolic process (GO:0006105)2.85422589
66NAD metabolic process (GO:0019674)2.85240898
67urate metabolic process (GO:0046415)2.82886969
68reverse cholesterol transport (GO:0043691)2.81880783
69bile acid and bile salt transport (GO:0015721)2.78866330
70protein carboxylation (GO:0018214)2.78569368
71peptidyl-glutamic acid carboxylation (GO:0017187)2.78569368
72cofactor catabolic process (GO:0051187)2.77201252
73bile acid metabolic process (GO:0008206)2.77011507
74sequestering of actin monomers (GO:0042989)2.76342576
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.75990836
76purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.75990836
77nitric oxide mediated signal transduction (GO:0007263)2.75911764
78homocysteine metabolic process (GO:0050667)2.75079894
79response to interferon-beta (GO:0035456)2.74339008
80regulation of relaxation of muscle (GO:1901077)2.74195343
81regulation of protein activation cascade (GO:2000257)2.74146347
82drug transmembrane transport (GO:0006855)2.74004137
83pyrimidine nucleoside catabolic process (GO:0046135)2.73231846
84aromatic amino acid family metabolic process (GO:0009072)2.73153675
85histone-serine phosphorylation (GO:0035404)2.72147558
86complement activation, alternative pathway (GO:0006957)2.72010102
87alkaloid metabolic process (GO:0009820)2.69746065
88branched-chain amino acid catabolic process (GO:0009083)2.69696033
89regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69658619
90dopamine transport (GO:0015872)2.69450622
91glyoxylate metabolic process (GO:0046487)2.68903095
92macromolecular complex remodeling (GO:0034367)2.67512745
93plasma lipoprotein particle remodeling (GO:0034369)2.67512745
94protein-lipid complex remodeling (GO:0034368)2.67512745
95response to nitrosative stress (GO:0051409)2.67003494
96amino-acid betaine metabolic process (GO:0006577)2.66719477
97branched-chain amino acid metabolic process (GO:0009081)2.66506352
98low-density lipoprotein particle remodeling (GO:0034374)2.65383762
99keratinocyte development (GO:0003334)2.64691954
100respiratory chain complex IV assembly (GO:0008535)2.64585902
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61708938
102pyridine nucleotide biosynthetic process (GO:0019363)2.60924206
103nicotinamide nucleotide biosynthetic process (GO:0019359)2.60924206
104nucleoside diphosphate biosynthetic process (GO:0009133)2.60237805
105regulation of sarcomere organization (GO:0060297)2.59202546
106positive regulation of glycoprotein biosynthetic process (GO:0010560)2.58322703
107cysteine metabolic process (GO:0006534)2.58271791
108regulation of fibrinolysis (GO:0051917)2.57857117
109mitochondrial respiratory chain complex assembly (GO:0033108)2.57398510
110regulation of complement activation (GO:0030449)2.56940380
111reflex (GO:0060004)2.56779064
112negative regulation of protein activation cascade (GO:2000258)2.56669648
113flavonoid metabolic process (GO:0009812)2.55973815
114positive regulation of protein autophosphorylation (GO:0031954)2.55760508
115positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.55305856
116photoreceptor cell maintenance (GO:0045494)2.54843482
117arginine metabolic process (GO:0006525)2.53899516
118purine ribonucleotide transport (GO:0015868)2.53687791
119adenosine metabolic process (GO:0046085)2.53642371
120regulation of acyl-CoA biosynthetic process (GO:0050812)2.52699707
121acylglycerol homeostasis (GO:0055090)2.52322949
122triglyceride homeostasis (GO:0070328)2.52322949
123cholesterol efflux (GO:0033344)2.51791139
124oxidative phosphorylation (GO:0006119)2.51679314
125DNA double-strand break processing (GO:0000729)2.51625817
126prostate gland growth (GO:0060736)2.51171658
127negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.49618822
128negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47744498
129fucose catabolic process (GO:0019317)2.46758478
130L-fucose metabolic process (GO:0042354)2.46758478
131L-fucose catabolic process (GO:0042355)2.46758478
132righting reflex (GO:0060013)2.46632798
133phosphorylated carbohydrate dephosphorylation (GO:0046838)2.46022904
134inositol phosphate dephosphorylation (GO:0046855)2.46022904
135arginine catabolic process (GO:0006527)2.44182251
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44146158
137presynaptic membrane assembly (GO:0097105)2.43751706
138regulation of sulfur metabolic process (GO:0042762)2.42460776
139negative regulation of DNA-dependent DNA replication (GO:2000104)2.41489335
140proline transport (GO:0015824)2.40283549
141vascular smooth muscle contraction (GO:0014829)2.37561462
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.35411322
143negative regulation of neurological system process (GO:0031645)2.34241983
144peptidyl-cysteine modification (GO:0018198)2.34240935
145somite rostral/caudal axis specification (GO:0032525)2.34181679
146behavioral response to nicotine (GO:0035095)2.32420848
147S-adenosylmethionine metabolic process (GO:0046500)2.31522425
148auditory receptor cell differentiation (GO:0042491)2.28409976
149thyroid hormone metabolic process (GO:0042403)2.27441909
150L-methionine salvage (GO:0071267)2.26494268
151L-methionine biosynthetic process (GO:0071265)2.26494268
152amino acid salvage (GO:0043102)2.26494268
153zinc ion transport (GO:0006829)2.26398949
154neuron fate determination (GO:0048664)2.24636219
155endocrine pancreas development (GO:0031018)2.24543986
156dorsal/ventral axis specification (GO:0009950)2.23237365
157presynaptic membrane organization (GO:0097090)2.20837568
158cullin deneddylation (GO:0010388)2.19980274
159preassembly of GPI anchor in ER membrane (GO:0016254)2.19099937
160atrial cardiac muscle cell action potential (GO:0086014)2.18485596
161G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.18471226
162pancreas development (GO:0031016)2.18375633
163negative regulation of keratinocyte proliferation (GO:0010839)2.17733735
164rRNA methylation (GO:0031167)2.16298452
165regulation of type B pancreatic cell apoptotic process (GO:2000674)2.16076587
166platelet dense granule organization (GO:0060155)2.15912358
167fatty acid transmembrane transport (GO:1902001)2.15054691
168transcytosis (GO:0045056)2.14585927
169regulation of neurotransmitter uptake (GO:0051580)2.12972975
170cilium morphogenesis (GO:0060271)2.12135280
171insulin secretion (GO:0030073)2.11940773
172axoneme assembly (GO:0035082)2.11028495
173positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.09999838
174cilium organization (GO:0044782)2.09065093
175regulation of coenzyme metabolic process (GO:0051196)2.09028274
176regulation of cofactor metabolic process (GO:0051193)2.09028274
177regulation of cardioblast differentiation (GO:0051890)2.07506322
178positive regulation of actin filament depolymerization (GO:0030836)2.07422284
179cornea development in camera-type eye (GO:0061303)2.07172043
180cilium assembly (GO:0042384)2.06413905
181positive regulation of glycoprotein metabolic process (GO:1903020)2.06287056
182regulation of keratinocyte proliferation (GO:0010837)2.06181595
183protein localization to cilium (GO:0061512)2.05613019
184positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.05151821
185C4-dicarboxylate transport (GO:0015740)2.04805600
186vitamin biosynthetic process (GO:0009110)2.04133809
187regulation of protein glycosylation (GO:0060049)2.04073048
188regulation of energy homeostasis (GO:2000505)2.02342697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.18303576
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.71216940
3* ZNF274_21170338_ChIP-Seq_K562_Hela3.03135892
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90911957
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90584633
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.87917431
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.79298010
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.74150711
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.70467302
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63391863
11TAF15_26573619_Chip-Seq_HEK293_Human2.52407594
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45278683
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43722188
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.43259929
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42088064
16VDR_22108803_ChIP-Seq_LS180_Human2.39498856
17GBX2_23144817_ChIP-Seq_PC3_Human2.28991996
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26443432
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24987946
20IGF1R_20145208_ChIP-Seq_DFB_Human2.17154730
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.16787354
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15626089
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15407211
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13500516
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.05413642
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04318737
27GATA1_22025678_ChIP-Seq_K562_Human1.96045534
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93227349
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.85146751
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84853512
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78251702
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77072882
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76977015
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.75685207
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74319547
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72622673
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71070251
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.69202778
39P300_19829295_ChIP-Seq_ESCs_Human1.68572246
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66945682
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64548801
42ELK1_19687146_ChIP-ChIP_HELA_Human1.63559747
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.62752603
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62072705
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59483653
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59228664
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59228664
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57723091
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.57609151
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57360007
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56486536
52STAT3_23295773_ChIP-Seq_U87_Human1.55711524
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.54178993
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53437959
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52841337
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48365729
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48172580
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47964015
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47801778
60P53_22387025_ChIP-Seq_ESCs_Mouse1.46656703
61AR_25329375_ChIP-Seq_VCAP_Human1.45643451
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.43113537
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42125971
64FUS_26573619_Chip-Seq_HEK293_Human1.41468508
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.40495936
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40198495
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40184179
68CDX2_22108803_ChIP-Seq_LS180_Human1.39599154
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38785284
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37186744
71TCF4_23295773_ChIP-Seq_U87_Human1.36343326
72RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34686712
73EWS_26573619_Chip-Seq_HEK293_Human1.34281842
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32841155
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32703027
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32249520
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31377752
78TCF4_22108803_ChIP-Seq_LS180_Human1.30671844
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.29543936
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28939898
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.26800170
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25327389
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.25057316
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.24903813
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24761039
86NANOG_19829295_ChIP-Seq_ESCs_Human1.24306738
87SOX2_19829295_ChIP-Seq_ESCs_Human1.24306738
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24075677
89* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23402128
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.23327025
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23312700
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22956576
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22492424
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22058957
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21987391
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19602503
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19303313
98RUNX2_22187159_ChIP-Seq_PCA_Human1.18803870
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18641480
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.18244482
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.18046167
102HTT_18923047_ChIP-ChIP_STHdh_Human1.17042853
103P300_18555785_Chip-Seq_ESCs_Mouse1.16745635
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15989973
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15342473
106OCT4_18555785_Chip-Seq_ESCs_Mouse1.14886986
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.14571714
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.13231234
109SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13220766
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10393506
111PU1_27457419_Chip-Seq_LIVER_Mouse1.10180907
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10091401
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09783482
114AR_20517297_ChIP-Seq_VCAP_Human1.09437559
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08799587
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08522908
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.08197596
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.08146093
119ER_23166858_ChIP-Seq_MCF-7_Human1.07907706
120SOX2_20726797_ChIP-Seq_SW620_Human1.07662754
121STAT1_17558387_ChIP-Seq_HELA_Human1.06548414
122SMAD4_21799915_ChIP-Seq_A2780_Human1.06357345
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05345902
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05171719
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04969015
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04969015
127GABP_17652178_ChIP-ChIP_JURKAT_Human1.04567133
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04503313
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.04489776
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03877065
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03772573
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03390704
133CBX2_27304074_Chip-Seq_ESCs_Mouse1.03307568
134SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03259818
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02814797
136ZFX_18555785_Chip-Seq_ESCs_Mouse1.02022704
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01494570
138PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01096668
139TBL1_22424771_ChIP-Seq_293T_Human1.00569283
140AHR_22903824_ChIP-Seq_MCF-7_Human0.99804554
141JUN_21703547_ChIP-Seq_K562_Human0.99703408
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99421011
143STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98757633
144SOX2_21211035_ChIP-Seq_LN229_Gbm0.98675489
145BCAT_22108803_ChIP-Seq_LS180_Human0.96977562
146IRF1_19129219_ChIP-ChIP_H3396_Human0.95766594
147CBP_20019798_ChIP-Seq_JUKART_Human0.94883121
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94883121
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94171068
150LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93532281
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.93420677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.15302981
2MP0005360_urolithiasis4.69683783
3MP0008875_abnormal_xenobiotic_pharmacok4.59836358
4MP0009697_abnormal_copulation4.43722841
5MP0005085_abnormal_gallbladder_physiolo4.22498774
6MP0002876_abnormal_thyroid_physiology3.67363269
7MP0005365_abnormal_bile_salt3.41669270
8MP0008057_abnormal_DNA_replication3.10259142
9MP0003806_abnormal_nucleotide_metabolis2.90656524
10MP0003195_calcinosis2.79756115
11MP0004782_abnormal_surfactant_physiolog2.72111379
12MP0008877_abnormal_DNA_methylation2.54705062
13MP0005084_abnormal_gallbladder_morpholo2.52915437
14MP0001764_abnormal_homeostasis2.41480695
15MP0009780_abnormal_chondrocyte_physiolo2.35746888
16MP0003252_abnormal_bile_duct2.33306145
17MP0003183_abnormal_peptide_metabolism2.29014470
18MP0003186_abnormal_redox_activity2.18015434
19MP0002102_abnormal_ear_morphology2.16397593
20MP0010329_abnormal_lipoprotein_level2.10000035
21MP0004147_increased_porphyrin_level2.09608446
22MP0005646_abnormal_pituitary_gland2.04042626
23MP0003787_abnormal_imprinting2.02906954
24MP0003943_abnormal_hepatobiliary_system2.01882699
25MP0006072_abnormal_retinal_apoptosis1.94991435
26MP0010234_abnormal_vibrissa_follicle1.79841400
27MP0002938_white_spotting1.73661244
28MP0004145_abnormal_muscle_electrophysio1.71970216
29MP0005332_abnormal_amino_acid1.71882626
30MP0003724_increased_susceptibility_to1.67858060
31MP0004215_abnormal_myocardial_fiber1.65327316
32MP0005187_abnormal_penis_morphology1.62073708
33MP0001666_abnormal_nutrient_absorption1.60731329
34MP0004043_abnormal_pH_regulation1.60179060
35MP0001835_abnormal_antigen_presentation1.59412466
36MP0010368_abnormal_lymphatic_system1.58103247
37MP0005408_hypopigmentation1.53988969
38MP0000427_abnormal_hair_cycle1.53339762
39MP0003191_abnormal_cellular_cholesterol1.52424587
40MP0002138_abnormal_hepatobiliary_system1.51419089
41MP0006054_spinal_hemorrhage1.50060024
42MP0005253_abnormal_eye_physiology1.48943702
43MP0002909_abnormal_adrenal_gland1.48040781
44MP0003283_abnormal_digestive_organ1.47333773
45MP0002877_abnormal_melanocyte_morpholog1.45561833
46MP0005551_abnormal_eye_electrophysiolog1.45471370
47MP0004270_analgesia1.42416994
48MP0000749_muscle_degeneration1.41775871
49MP0000372_irregular_coat_pigmentation1.41095449
50MP0003890_abnormal_embryonic-extraembry1.38692655
51MP0002009_preneoplasia1.38077461
52MP0002132_abnormal_respiratory_system1.36782017
53MP0003122_maternal_imprinting1.34822767
54MP0000569_abnormal_digit_pigmentation1.33289284
55MP0009785_altered_susceptibility_to1.32618580
56MP0004885_abnormal_endolymph1.31900384
57MP0002254_reproductive_system_inflammat1.29918436
58MP0005319_abnormal_enzyme/_coenzyme1.29719339
59MP0006036_abnormal_mitochondrial_physio1.29023830
60MP0001984_abnormal_olfaction1.27701084
61MP0005645_abnormal_hypothalamus_physiol1.27190544
62MP0003718_maternal_effect1.24426440
63MP0003121_genomic_imprinting1.19925614
64MP0005248_abnormal_Harderian_gland1.19729678
65MP0010678_abnormal_skin_adnexa1.19526703
66MP0001986_abnormal_taste_sensitivity1.19010012
67MP0002638_abnormal_pupillary_reflex1.17902131
68MP0005171_absent_coat_pigmentation1.17487580
69MP0002234_abnormal_pharynx_morphology1.17438065
70MP0005584_abnormal_enzyme/coenzyme_acti1.15711810
71MP0002751_abnormal_autonomic_nervous1.15538550
72MP0004019_abnormal_vitamin_homeostasis1.14997042
73MP0001879_abnormal_lymphatic_vessel1.14840908
74MP0003119_abnormal_digestive_system1.14067160
75MP0002736_abnormal_nociception_after1.13440891
76MP0009764_decreased_sensitivity_to1.13219807
77MP0009046_muscle_twitch1.12208882
78MP0001944_abnormal_pancreas_morphology1.11444435
79MP0000566_synostosis1.10408600
80MP0003136_yellow_coat_color1.10318262
81MP0000631_abnormal_neuroendocrine_gland1.07088034
82MP0000647_abnormal_sebaceous_gland1.06581298
83MP0002837_dystrophic_cardiac_calcinosis1.06269267
84MP0010386_abnormal_urinary_bladder1.06134296
85MP0004133_heterotaxia1.05406269
86MP0003011_delayed_dark_adaptation1.03447768
87MP0002148_abnormal_hypersensitivity_rea1.02813933
88MP0001542_abnormal_bone_strength1.01852306
89MP0000013_abnormal_adipose_tissue1.01353247
90MP0003941_abnormal_skin_development1.01225719
91MP0002163_abnormal_gland_morphology0.99202067
92MP0008872_abnormal_physiological_respon0.99059268
93MP0005266_abnormal_metabolism0.98609832
94MP0004085_abnormal_heartbeat0.98056550
95MP0001968_abnormal_touch/_nociception0.98025636
96MP0005083_abnormal_biliary_tract0.96656315
97MP0004084_abnormal_cardiac_muscle0.96199042
98MP0005503_abnormal_tendon_morphology0.95267061
99MP0000383_abnormal_hair_follicle0.94490842
100MP0001485_abnormal_pinna_reflex0.93812916
101MP0000681_abnormal_thyroid_gland0.93458157
102MP0003868_abnormal_feces_composition0.93129025
103MP0002118_abnormal_lipid_homeostasis0.92543645
104MP0005647_abnormal_sex_gland0.92465747
105MP0004924_abnormal_behavior0.90884878
106MP0005386_behavior/neurological_phenoty0.90884878
107MP0002127_abnormal_cardiovascular_syste0.90171209
108MP0005464_abnormal_platelet_physiology0.89667418
109MP0001188_hyperpigmentation0.89209745
110MP0008469_abnormal_protein_level0.88818824
111MP0000613_abnormal_salivary_gland0.87810340
112MP0005620_abnormal_muscle_contractility0.86797293
113MP0000230_abnormal_systemic_arterial0.85611982
114MP0005376_homeostasis/metabolism_phenot0.85533204
115MP0002272_abnormal_nervous_system0.85266386
116MP0003279_aneurysm0.82807214
117MP0003937_abnormal_limbs/digits/tail_de0.82747125
118MP0001853_heart_inflammation0.82710798
119MP0001486_abnormal_startle_reflex0.82222225
120MP0001661_extended_life_span0.81786588
121MP0002972_abnormal_cardiac_muscle0.80574695
122MP0009643_abnormal_urine_homeostasis0.80036941
123MP0009745_abnormal_behavioral_response0.79326289
124MP0000609_abnormal_liver_physiology0.79314956
125MP0005395_other_phenotype0.78722649
126MP0002166_altered_tumor_susceptibility0.77662283
127MP0005671_abnormal_response_to0.76008621
128MP0006292_abnormal_olfactory_placode0.75890855
129MP0005394_taste/olfaction_phenotype0.75160827
130MP0005499_abnormal_olfactory_system0.75160827
131MP0002693_abnormal_pancreas_physiology0.75147981
132MP0000598_abnormal_liver_morphology0.73928415
133MP0008775_abnormal_heart_ventricle0.73599647
134MP0005174_abnormal_tail_pigmentation0.72904976
135MP0001177_atelectasis0.72730716
136MP0003646_muscle_fatigue0.72520413
137MP0002078_abnormal_glucose_homeostasis0.72470060
138MP0002928_abnormal_bile_duct0.69593803
139MP0005025_abnormal_response_to0.69135938
140MP0006276_abnormal_autonomic_nervous0.68000202
141MP0000516_abnormal_urinary_system0.67059893
142MP0005367_renal/urinary_system_phenotyp0.67059893
143MP0005636_abnormal_mineral_homeostasis0.66314184
144MP0009642_abnormal_blood_homeostasis0.65864104
145MP0001756_abnormal_urination0.65060940
146MP0009765_abnormal_xenobiotic_induced0.64761467
147MP0005220_abnormal_exocrine_pancreas0.64759630
148MP0005379_endocrine/exocrine_gland_phen0.64514998
149MP0004808_abnormal_hematopoietic_stem0.64064267
150MP0002160_abnormal_reproductive_system0.63582533
151MP0004484_altered_response_of0.63490580
152MP0009763_increased_sensitivity_to0.63339158
153MP0000343_altered_response_to0.62729411
154MP0006035_abnormal_mitochondrial_morpho0.61587970
155MP0002419_abnormal_innate_immunity0.61365695
156MP0001790_abnormal_immune_system0.61107384
157MP0005387_immune_system_phenotype0.61107384
158MP0003763_abnormal_thymus_physiology0.60591513
159MP0000538_abnormal_urinary_bladder0.59736021
160MP0005535_abnormal_body_temperature0.59082187
161MP0004036_abnormal_muscle_relaxation0.58938695

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)4.29799776
2Abnormality of the anterior horn cell (HP:0006802)4.29799776
3Hypothermia (HP:0002045)4.18035594
4Renal cortical cysts (HP:0000803)4.03634961
5Prolonged partial thromboplastin time (HP:0003645)3.82019854
6Gaze-evoked nystagmus (HP:0000640)3.71533384
7Generalized aminoaciduria (HP:0002909)3.69732258
8Intestinal atresia (HP:0011100)3.54319910
9Abnormality of the lower motor neuron (HP:0002366)3.41952396
10Pancreatic cysts (HP:0001737)3.41915623
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.34572591
12Amyotrophic lateral sclerosis (HP:0007354)3.26792459
13Hypobetalipoproteinemia (HP:0003563)3.10325340
14Joint hemorrhage (HP:0005261)3.08424788
15Hepatic necrosis (HP:0002605)3.00904880
16Calf muscle hypertrophy (HP:0008981)2.99734606
17Fat malabsorption (HP:0002630)2.99462262
18Abnormality of monocarboxylic acid metabolism (HP:0010996)2.98254122
19Abnormality of fatty-acid metabolism (HP:0004359)2.94646219
20Intrahepatic cholestasis (HP:0001406)2.93767649
21Hypoglycemic coma (HP:0001325)2.89194948
22Hyperinsulinemic hypoglycemia (HP:0000825)2.87981219
23Abnormality of the intrinsic pathway (HP:0010989)2.87661827
24Proximal tubulopathy (HP:0000114)2.87305486
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87094302
26Chronic hepatic failure (HP:0100626)2.84061088
27Conjugated hyperbilirubinemia (HP:0002908)2.83801945
28Abnormality of urine glucose concentration (HP:0011016)2.82251923
29Glycosuria (HP:0003076)2.82251923
30Abnormal hair whorl (HP:0010721)2.79997039
31Muscle hypertrophy of the lower extremities (HP:0008968)2.77135494
32Steatorrhea (HP:0002570)2.75736822
33Alveolar cell carcinoma (HP:0006519)2.73556138
34Medial flaring of the eyebrow (HP:0010747)2.70113002
35Hypoplasia of the thymus (HP:0000778)2.63270712
36Abnormal mitochondria in muscle tissue (HP:0008316)2.62532811
37Deep venous thrombosis (HP:0002625)2.62327140
38Fair hair (HP:0002286)2.60480343
39Abnormality of methionine metabolism (HP:0010901)2.58374330
40Abnormality of the renal cortex (HP:0011035)2.57971593
41Reduced antithrombin III activity (HP:0001976)2.57223505
42Abnormality of the common coagulation pathway (HP:0010990)2.57088818
43Acute necrotizing encephalopathy (HP:0006965)2.55863670
44Acute encephalopathy (HP:0006846)2.53984489
45Large for gestational age (HP:0001520)2.51177823
46Hepatocellular necrosis (HP:0001404)2.46591376
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46356171
48Spontaneous abortion (HP:0005268)2.45687968
49Hyperventilation (HP:0002883)2.45666696
50Cerebral edema (HP:0002181)2.45345562
51Nausea (HP:0002018)2.44788151
52Hyperglycemia (HP:0003074)2.43999719
53Acanthocytosis (HP:0001927)2.41495271
54Nephronophthisis (HP:0000090)2.39124443
55Mitochondrial inheritance (HP:0001427)2.35456684
56Metabolic acidosis (HP:0001942)2.35339813
57Abnormality of midbrain morphology (HP:0002418)2.35272071
58Molar tooth sign on MRI (HP:0002419)2.35272071
59Progressive macrocephaly (HP:0004481)2.34787510
60Abnormality of vitamin B metabolism (HP:0004340)2.32923383
61Neoplasm of the adrenal cortex (HP:0100641)2.30760463
62Abnormality of pyrimidine metabolism (HP:0004353)2.29945334
63Hypolipoproteinemia (HP:0010981)2.29780995
64Neoplasm of the adrenal gland (HP:0100631)2.27785055
65Abnormality of the renal medulla (HP:0100957)2.27721341
66Increased CSF lactate (HP:0002490)2.27325740
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25452555
68Abolished electroretinogram (ERG) (HP:0000550)2.25323768
69Abnormality of the labia minora (HP:0012880)2.24831155
70Aplastic anemia (HP:0001915)2.23299246
71Enlarged kidneys (HP:0000105)2.21835658
72Hyperlipoproteinemia (HP:0010980)2.17987645
73Patchy hypopigmentation of hair (HP:0011365)2.17424485
74Hyperammonemia (HP:0001987)2.14687957
75Lethargy (HP:0001254)2.14171864
76Neonatal hypoglycemia (HP:0001998)2.14013002
77Xanthomatosis (HP:0000991)2.13253504
78Hyperglycinemia (HP:0002154)2.12501348
79Neoplasm of the tracheobronchial system (HP:0100552)2.11688993
80Hyperbilirubinemia (HP:0002904)2.11450862
81Conjunctival telangiectasia (HP:0000524)2.10567163
82Ependymoma (HP:0002888)2.10436773
83Cystic liver disease (HP:0006706)2.10258047
84Type I transferrin isoform profile (HP:0003642)2.07311331
85Abnormality of the fovea (HP:0000493)2.06958489
86Dicarboxylic aciduria (HP:0003215)2.05654028
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05654028
88Autoimmune thrombocytopenia (HP:0001973)2.05020736
89Volvulus (HP:0002580)2.04428515
90Atrophy/Degeneration involving motor neurons (HP:0007373)2.04164903
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03814697
92Furrowed tongue (HP:0000221)2.03534068
93Upper motor neuron abnormality (HP:0002127)2.02976837
94Aplasia/Hypoplasia of the fovea (HP:0008060)2.02404863
95Hypoplasia of the fovea (HP:0007750)2.02404863
96Acute hepatic failure (HP:0006554)1.99294122
97Hypomagnesemia (HP:0002917)1.98896602
98Methylmalonic acidemia (HP:0002912)1.97179333
99Renal tubular dysfunction (HP:0000124)1.96960275
100Complement deficiency (HP:0004431)1.96664657
101Distal lower limb muscle weakness (HP:0009053)1.96185998
102Ketosis (HP:0001946)1.95677288
103Astrocytoma (HP:0009592)1.95313610
104Abnormality of the astrocytes (HP:0100707)1.95313610
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.95079466
106Congenital primary aphakia (HP:0007707)1.94877952
107Recurrent gram-negative bacterial infections (HP:0005420)1.94806514
108Genital tract atresia (HP:0001827)1.94432457
109Pancreatic fibrosis (HP:0100732)1.94046840
110Hamartoma of the eye (HP:0010568)1.93827890
111Abnormality of macular pigmentation (HP:0008002)1.93578345
112Osteomalacia (HP:0002749)1.93401213
113Gait imbalance (HP:0002141)1.93063006
114Abnormal pancreas size (HP:0012094)1.92386128
115Pancreatic islet-cell hyperplasia (HP:0004510)1.92322082
116Enlarged penis (HP:0000040)1.92046383
117Hyperglycinuria (HP:0003108)1.90904934
1183-Methylglutaconic aciduria (HP:0003535)1.90691061
119Exercise intolerance (HP:0003546)1.89912061
120Thyroiditis (HP:0100646)1.89707676
121Congenital sensorineural hearing impairment (HP:0008527)1.87822921
122Ketoacidosis (HP:0001993)1.87315246
123Hypoalphalipoproteinemia (HP:0003233)1.87188143
124Nephrogenic diabetes insipidus (HP:0009806)1.86849400
125Lipid accumulation in hepatocytes (HP:0006561)1.86452451
126Abnormality of the calf musculature (HP:0001430)1.86434011
127Gastrointestinal atresia (HP:0002589)1.86152667
128Methylmalonic aciduria (HP:0012120)1.85488878
129Abnormality of serum amino acid levels (HP:0003112)1.85335379
130Abnormality of nucleobase metabolism (HP:0010932)1.84814460
131Generalized hypopigmentation of hair (HP:0011358)1.84300979
132Impaired proprioception (HP:0010831)1.83977292
133Bile duct proliferation (HP:0001408)1.83712904
134Abnormal biliary tract physiology (HP:0012439)1.83712904
135Cerebral palsy (HP:0100021)1.83400172
136B lymphocytopenia (HP:0010976)1.83212973
137Abnormality of B cell number (HP:0010975)1.83212973
138Abnormality of vitamin metabolism (HP:0100508)1.83081978
139Polydipsia (HP:0001959)1.82993353
140Abnormal drinking behavior (HP:0030082)1.82993353
141Lactic acidosis (HP:0003128)1.82917778
142Vaginal atresia (HP:0000148)1.82737505
143Type II lissencephaly (HP:0007260)1.82063537
144Exercise-induced muscle cramps (HP:0003710)1.82010669
145Palpitations (HP:0001962)1.81348800
146Tubular atrophy (HP:0000092)1.80079801
147Glioma (HP:0009733)1.79671443
148Hemiparesis (HP:0001269)1.78508314
149Oculomotor apraxia (HP:0000657)1.76916216
150Microvesicular hepatic steatosis (HP:0001414)1.76672836
151Abnormality of the pancreatic islet cells (HP:0006476)1.76047570
152Abnormality of endocrine pancreas physiology (HP:0012093)1.76047570
153Broad-based gait (HP:0002136)1.74576373
154Hypoglycemic seizures (HP:0002173)1.74481617
155Oligomenorrhea (HP:0000876)1.74269799
156Epiphyseal stippling (HP:0010655)1.73113103
157True hermaphroditism (HP:0010459)1.72863021
158Abnormality of serine family amino acid metabolism (HP:0010894)1.71664450
159Abnormality of glycine metabolism (HP:0010895)1.71664450
160Aqueductal stenosis (HP:0002410)1.71585443
161Hepatocellular carcinoma (HP:0001402)1.71574111
162Joint swelling (HP:0001386)1.71362980
163Abnormality of the vitamin B12 metabolism (HP:0004341)1.71297485
164Tubulointerstitial nephritis (HP:0001970)1.71204713
165Congenital stationary night blindness (HP:0007642)1.71159318
166Symptomatic seizures (HP:0011145)1.70626560
167Abnormality of incisor morphology (HP:0011063)1.70543322
168Male pseudohermaphroditism (HP:0000037)1.69830563
169Decreased circulating renin level (HP:0003351)1.67290674
170Insulin-resistant diabetes mellitus (HP:0000831)1.67221368
171Delayed gross motor development (HP:0002194)1.65330825
172Occipital encephalocele (HP:0002085)1.65052807
173Congenital hepatic fibrosis (HP:0002612)1.64830841
174Postaxial hand polydactyly (HP:0001162)1.62269223
175Abnormality of the vasculature of the conjunctiva (HP:0008054)1.61582142
176Absent speech (HP:0001344)1.59968929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.33645274
2CASK3.20944468
3MAP3K123.13871743
4BMPR23.07589506
5WNK33.00108149
6ERBB32.98912439
7MAP3K142.92452085
8ZAK2.75057655
9TNIK2.53850140
10AKT32.50689314
11SIK32.49234723
12MYLK2.43303452
13MAP4K22.37796130
14STK38L2.26452882
15FGFR22.21724062
16TXK2.20539484
17TRIM282.08569051
18MST41.91804150
19PAK31.85366888
20STK391.85271704
21PHKG11.82364686
22PHKG21.82364686
23EIF2AK31.81042679
24SGK21.70969464
25OXSR11.67339409
26MAP2K71.65796808
27PIK3CA1.62154542
28OBSCN1.60093888
29NEK91.46143474
30TIE11.44948723
31TSSK61.44433832
32BCR1.41868316
33MKNK11.38566103
34SRPK11.38250144
35INSRR1.35830481
36NUAK11.34251797
37CDK81.33890153
38YES11.30530335
39ADRBK21.30042983
40MAP3K41.28662394
41BCKDK1.27466364
42PRPF4B1.25882241
43IRAK41.25820567
44CSNK1G11.24596455
45ACVR1B1.22830082
46TEC1.21661892
47STK241.19207571
48PLK21.18635338
49MKNK21.17287310
50FLT31.15245855
51PINK11.14272666
52MUSK1.10840227
53NEK61.09438496
54WNK41.07917602
55STK31.07398730
56CDK61.06684682
57JAK31.03134352
58MAPK131.03042578
59PDK21.01656366
60IKBKE0.98403953
61SGK30.97499012
62CSNK1G20.97346592
63CSNK1G30.97024779
64TRPM70.96242475
65TNK20.93874204
66GRK70.92381148
67BRSK20.91669371
68EIF2AK20.91044769
69PNCK0.90976346
70CHUK0.89481461
71LMTK20.86884856
72TAF10.86400193
73CAMKK20.86315448
74CSNK1A1L0.83488683
75TAOK20.83424257
76TYK20.83092872
77IKBKB0.81177555
78EIF2AK10.79605580
79PIK3CG0.79182739
80IRAK30.76937982
81RPS6KB10.76230804
82PLK40.73233534
83MAP2K60.72183717
84BMPR1B0.71558412
85FGFR30.69545189
86LATS10.69186013
87SGK4940.68972503
88SGK2230.68972503
89JAK10.68531209
90PRKAA20.66876923
91CCNB10.65915354
92MAP3K110.65562880
93NLK0.64312872
94PRKCG0.64018317
95PRKG20.63393799
96CDK30.62344723
97EPHA40.62335118
98MARK10.62327227
99MAP2K30.61538893
100MAP3K30.61401869
101PIM10.60295085
102PRKCI0.58635599
103NTRK30.56701261
104MAP2K40.55908036
105CAMK2D0.54726978
106PRKCE0.53968068
107BTK0.53765816
108PLK10.53550743
109PRKAA10.52552103
110WEE10.52211173
111VRK10.50884943
112EPHB20.49889856
113PDK40.49318008
114PDK30.49318008
115PIM20.49235525
116MAPK70.46945854
117TGFBR20.46751564
118CSNK1A10.45153646
119MAP4K10.45134505
120SYK0.44371313
121RPS6KA60.44212795
122IGF1R0.42412830
123PLK30.42150698
124CAMK2A0.41243024
125FGFR10.40345304
126PRKG10.40072641
127MAP3K50.39863597
128ATM0.39601717
129FER0.39253502
130PRKCQ0.38536201
131MAPK120.37241859
132MAPKAPK50.36549031
133CSNK1D0.36094776
134TGFBR10.35932854
135DAPK20.35342313
136ADRBK10.34824918
137STK110.34757911
138GRK10.33873110
139PRKACA0.33873088
140PRKCD0.33078361
141LIMK10.32905788
142MINK10.32716826
143TLK10.32337956
144CSNK2A10.32313228
145MAPK30.31863577
146PTK2B0.31793044
147PRKACB0.31381891
148TBK10.31028969
149STK160.30727536
150CSNK1E0.30460975
151MAP2K10.30417690
152BUB10.30333964
153ERBB40.30195599
154NEK10.29883813

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000403.30885538
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.29591542
3Caffeine metabolism_Homo sapiens_hsa002323.28410482
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11427449
5Drug metabolism - other enzymes_Homo sapiens_hsa009832.58878804
6Peroxisome_Homo sapiens_hsa041462.39733335
7Vitamin B6 metabolism_Homo sapiens_hsa007502.39515352
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37681332
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31615991
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.26524844
11Chemical carcinogenesis_Homo sapiens_hsa052042.23809111
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.23413259
13Protein export_Homo sapiens_hsa030602.23277463
14Starch and sucrose metabolism_Homo sapiens_hsa005002.16925824
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14262805
16Propanoate metabolism_Homo sapiens_hsa006402.13234981
17Sulfur metabolism_Homo sapiens_hsa009202.01283899
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.97175524
19Complement and coagulation cascades_Homo sapiens_hsa046101.95892517
20Retinol metabolism_Homo sapiens_hsa008301.88964450
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88356225
22Fatty acid degradation_Homo sapiens_hsa000711.85504718
23Tryptophan metabolism_Homo sapiens_hsa003801.83291119
24Arginine biosynthesis_Homo sapiens_hsa002201.80854190
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78942137
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72556553
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71746386
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68437141
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67948293
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63258639
31Phenylalanine metabolism_Homo sapiens_hsa003601.61563059
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61044879
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47793716
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46329108
35Phototransduction_Homo sapiens_hsa047441.46219996
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.43275434
37beta-Alanine metabolism_Homo sapiens_hsa004101.41609884
38Histidine metabolism_Homo sapiens_hsa003401.39621219
39Circadian rhythm_Homo sapiens_hsa047101.36554350
40Nitrogen metabolism_Homo sapiens_hsa009101.34593120
41Tyrosine metabolism_Homo sapiens_hsa003501.28745522
42Insulin secretion_Homo sapiens_hsa049111.27501318
43Linoleic acid metabolism_Homo sapiens_hsa005911.27040970
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25697839
45Pyruvate metabolism_Homo sapiens_hsa006201.25459476
46Oxidative phosphorylation_Homo sapiens_hsa001901.24528074
47Fatty acid elongation_Homo sapiens_hsa000621.23616297
48ABC transporters_Homo sapiens_hsa020101.21959443
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20607504
50Galactose metabolism_Homo sapiens_hsa000521.20525191
51Fatty acid metabolism_Homo sapiens_hsa012121.08258414
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04326554
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03685766
54Butanoate metabolism_Homo sapiens_hsa006501.03288971
55Steroid biosynthesis_Homo sapiens_hsa001001.02957124
56Ether lipid metabolism_Homo sapiens_hsa005651.01182102
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00979725
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00640523
59RNA polymerase_Homo sapiens_hsa030200.98359463
60PPAR signaling pathway_Homo sapiens_hsa033200.98341847
61Parkinsons disease_Homo sapiens_hsa050120.96217481
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95831716
63Non-homologous end-joining_Homo sapiens_hsa034500.91199547
64Carbon metabolism_Homo sapiens_hsa012000.90164822
65Collecting duct acid secretion_Homo sapiens_hsa049660.89960018
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89369845
67Folate biosynthesis_Homo sapiens_hsa007900.87332747
68Homologous recombination_Homo sapiens_hsa034400.86716712
69Vitamin digestion and absorption_Homo sapiens_hsa049770.86199325
70Fanconi anemia pathway_Homo sapiens_hsa034600.86142738
71Selenocompound metabolism_Homo sapiens_hsa004500.85542474
72Staphylococcus aureus infection_Homo sapiens_hsa051500.82563214
73Proteasome_Homo sapiens_hsa030500.81044329
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77866989
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.77129065
76Allograft rejection_Homo sapiens_hsa053300.76908947
77Cardiac muscle contraction_Homo sapiens_hsa042600.76885430
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76434187
79Regulation of autophagy_Homo sapiens_hsa041400.76121440
80Glutathione metabolism_Homo sapiens_hsa004800.74161400
81Mineral absorption_Homo sapiens_hsa049780.72018622
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71194133
83Rheumatoid arthritis_Homo sapiens_hsa053230.70807732
84Arachidonic acid metabolism_Homo sapiens_hsa005900.69385424
85Metabolic pathways_Homo sapiens_hsa011000.68921133
86Glucagon signaling pathway_Homo sapiens_hsa049220.68348091
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.68016906
88Renin secretion_Homo sapiens_hsa049240.66921186
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66846370
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66250736
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62673491
92Fructose and mannose metabolism_Homo sapiens_hsa000510.61908816
93Taste transduction_Homo sapiens_hsa047420.61632046
94Circadian entrainment_Homo sapiens_hsa047130.61157689
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59894890
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59300274
97Alzheimers disease_Homo sapiens_hsa050100.59299794
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.58947088
99Autoimmune thyroid disease_Homo sapiens_hsa053200.58163709
100Nicotine addiction_Homo sapiens_hsa050330.55604034
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54711785
102Tight junction_Homo sapiens_hsa045300.54493454
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53838502
104Graft-versus-host disease_Homo sapiens_hsa053320.53370439
105TGF-beta signaling pathway_Homo sapiens_hsa043500.51853578
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51819540
107Salivary secretion_Homo sapiens_hsa049700.51511279
108Olfactory transduction_Homo sapiens_hsa047400.50594481
109Serotonergic synapse_Homo sapiens_hsa047260.50175195
110Sphingolipid metabolism_Homo sapiens_hsa006000.50085269
111Amphetamine addiction_Homo sapiens_hsa050310.49992507
112One carbon pool by folate_Homo sapiens_hsa006700.49777908
113Biosynthesis of amino acids_Homo sapiens_hsa012300.48759232
114Glycerolipid metabolism_Homo sapiens_hsa005610.48723219
115Huntingtons disease_Homo sapiens_hsa050160.47960107
116Legionellosis_Homo sapiens_hsa051340.46892047
117Oocyte meiosis_Homo sapiens_hsa041140.46809092
118Vibrio cholerae infection_Homo sapiens_hsa051100.46354162
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45851347
120Bile secretion_Homo sapiens_hsa049760.45629131
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.45563652
122Fat digestion and absorption_Homo sapiens_hsa049750.44249353
123Hippo signaling pathway_Homo sapiens_hsa043900.43815313
124Hedgehog signaling pathway_Homo sapiens_hsa043400.42356894
125RNA degradation_Homo sapiens_hsa030180.42042304
126Thyroid cancer_Homo sapiens_hsa052160.41417779
127Purine metabolism_Homo sapiens_hsa002300.41065980
128Primary immunodeficiency_Homo sapiens_hsa053400.37973757
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36162195
130Phagosome_Homo sapiens_hsa041450.35410994
131Pentose phosphate pathway_Homo sapiens_hsa000300.33050283
132Arginine and proline metabolism_Homo sapiens_hsa003300.32206429
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32095909
134Basal transcription factors_Homo sapiens_hsa030220.29388645
135Pyrimidine metabolism_Homo sapiens_hsa002400.29361882
136Measles_Homo sapiens_hsa051620.29274435
137Type I diabetes mellitus_Homo sapiens_hsa049400.25592609
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.21926754
139Antigen processing and presentation_Homo sapiens_hsa046120.21025350
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.17731786
141African trypanosomiasis_Homo sapiens_hsa051430.17407091

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