SYNPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerulus development (GO:0032835)7.34625480
2actin-myosin filament sliding (GO:0033275)7.16014206
3muscle filament sliding (GO:0030049)7.16014206
4sarcoplasmic reticulum calcium ion transport (GO:0070296)6.39255375
5actin-mediated cell contraction (GO:0070252)5.92850053
6myofibril assembly (GO:0030239)5.37202975
7epithelial cell differentiation involved in kidney development (GO:0035850)5.20629116
8regulation of relaxation of muscle (GO:1901077)5.12978208
9skeletal muscle contraction (GO:0003009)5.02832480
10regulation of skeletal muscle contraction (GO:0014819)4.95990346
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.95520580
12striated muscle contraction (GO:0006941)4.95396108
13cardiac muscle contraction (GO:0060048)4.88648510
14creatine metabolic process (GO:0006600)4.68074648
15regulation of axon guidance (GO:1902667)4.61628855
16actin filament-based movement (GO:0030048)4.59984502
17regulation of cell communication by electrical coupling (GO:0010649)4.57039926
18endothelial cell chemotaxis (GO:0035767)4.48273280
19regulation of actin filament-based movement (GO:1903115)4.41746056
20NADH metabolic process (GO:0006734)4.36738435
21cardiac muscle hypertrophy (GO:0003300)4.26556489
22regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.19560275
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.18349310
24negative regulation of axon guidance (GO:1902668)4.11225427
25striated muscle hypertrophy (GO:0014897)4.08807615
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03920513
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.02838780
28actomyosin structure organization (GO:0031032)4.00453086
29positive regulation of p38MAPK cascade (GO:1900745)3.99042160
30vascular endothelial growth factor signaling pathway (GO:0038084)3.95562688
31regulation of axon extension involved in axon guidance (GO:0048841)3.90034936
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.87766787
33muscle contraction (GO:0006936)3.82413110
34coronary vasculature morphogenesis (GO:0060977)3.67233493
35muscle hypertrophy (GO:0014896)3.67221102
36regulation of the force of heart contraction (GO:0002026)3.62960881
37regulation of p38MAPK cascade (GO:1900744)3.60589174
38stress fiber assembly (GO:0043149)3.58468451
39cell migration involved in sprouting angiogenesis (GO:0002042)3.58156895
40cell adhesion mediated by integrin (GO:0033627)3.51687560
41response to muscle activity (GO:0014850)3.50023527
42muscle system process (GO:0003012)3.47499230
43response to inactivity (GO:0014854)3.47413169
44neuron projection extension involved in neuron projection guidance (GO:1902284)3.46284427
45axon extension involved in axon guidance (GO:0048846)3.46284427
46cardiac muscle adaptation (GO:0014887)3.46223397
47cardiac muscle hypertrophy in response to stress (GO:0014898)3.46223397
48muscle hypertrophy in response to stress (GO:0003299)3.46223397
49plasma membrane repair (GO:0001778)3.44550048
50protein localization to endosome (GO:0036010)3.43998063
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.43726798
52skeletal muscle fiber development (GO:0048741)3.38904678
53lymphangiogenesis (GO:0001946)3.36611856
54positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.36488391
55renal filtration (GO:0097205)3.35946583
56regulation of striated muscle contraction (GO:0006942)3.30480879
57striated muscle adaptation (GO:0014888)3.29782236
58kidney mesenchyme development (GO:0072074)3.27655084
59cytoskeletal anchoring at plasma membrane (GO:0007016)3.26670906
60regulation of calcium ion transmembrane transport (GO:1903169)3.26497725
61regulation of calcium ion transmembrane transporter activity (GO:1901019)3.26497725
62activation of Rac GTPase activity (GO:0032863)3.25302674
63skeletal muscle adaptation (GO:0043501)3.22518987
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.21496773
65venous blood vessel morphogenesis (GO:0048845)3.19644379
66protein heterotrimerization (GO:0070208)3.18006572
67glycogen catabolic process (GO:0005980)3.17894513
68regulation of glomerular filtration (GO:0003093)3.15672772
69cardiac muscle tissue morphogenesis (GO:0055008)3.10615103
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07958015
71vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.07802261
72myotube cell development (GO:0014904)3.05092257
73muscle tissue morphogenesis (GO:0060415)3.04162299
74metanephric mesenchyme development (GO:0072075)3.03843577
75positive regulation of cell adhesion mediated by integrin (GO:0033630)3.01075933
76glucan catabolic process (GO:0009251)3.00671389
77adult heart development (GO:0007512)2.98359143
78positive regulation of vascular permeability (GO:0043117)2.97638758
79carnitine shuttle (GO:0006853)2.95072288
80negative regulation of calcium ion transmembrane transport (GO:1903170)2.94400097
81negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.94400097
82myoblast fusion (GO:0007520)2.91925905
83cellular response to epinephrine stimulus (GO:0071872)2.89451448
84skeletal muscle tissue development (GO:0007519)2.85956857
85angiotensin maturation (GO:0002003)2.85804912
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.85358405
87negative regulation of potassium ion transmembrane transport (GO:1901380)2.84255161
88synaptic vesicle maturation (GO:0016188)2.81735943
89regulation of membrane repolarization (GO:0060306)2.81684385
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80788562
91negative regulation of axon extension involved in axon guidance (GO:0048843)2.80701466
92detection of calcium ion (GO:0005513)2.79387335
93response to epinephrine (GO:0071871)2.79119963
94regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.77410539
95cellular polysaccharide catabolic process (GO:0044247)2.76254617
96cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.75662621
97blood vessel endothelial cell migration (GO:0043534)2.75194864
98muscle fiber development (GO:0048747)2.74981405
99relaxation of cardiac muscle (GO:0055119)2.74124479
100relaxation of muscle (GO:0090075)2.73972319
101positive regulation of axon extension (GO:0045773)2.72537365
102muscle adaptation (GO:0043500)2.71681154
103regulation of synapse structural plasticity (GO:0051823)2.70606763
104regulation of sequestering of triglyceride (GO:0010889)2.70202982
105neuronal action potential propagation (GO:0019227)2.70125536
106cardiac muscle cell development (GO:0055013)2.69434618
107glucan biosynthetic process (GO:0009250)2.67622068
108glycogen biosynthetic process (GO:0005978)2.67622068
109surfactant homeostasis (GO:0043129)2.67552835
110regulation of cardiac muscle cell contraction (GO:0086004)2.66429025
111wound healing, spreading of epidermal cells (GO:0035313)2.65438026
112negative regulation of homotypic cell-cell adhesion (GO:0034111)2.63747552
113epithelial cell-cell adhesion (GO:0090136)2.63150430
114cellular potassium ion homeostasis (GO:0030007)2.62622730
115patterning of blood vessels (GO:0001569)2.62442757
116peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.60890167
117renal system process involved in regulation of blood volume (GO:0001977)2.60516788
118syncytium formation by plasma membrane fusion (GO:0000768)2.59774542
119regulation of sodium ion transmembrane transport (GO:1902305)2.59285553
120regulation of heart contraction (GO:0008016)2.58876170
1212-oxoglutarate metabolic process (GO:0006103)2.57723730
122regulation of endothelial cell chemotaxis (GO:2001026)2.57035132
123chemical homeostasis within a tissue (GO:0048875)2.56250158
124cell communication by electrical coupling (GO:0010644)2.56052307
125fatty acid transmembrane transport (GO:1902001)2.55461061
126cardiac cell development (GO:0055006)2.55065513
127ventricular cardiac muscle cell action potential (GO:0086005)2.54639444
128lung vasculature development (GO:0060426)2.54243060
129regulation of muscle system process (GO:0090257)2.53661761
130positive regulation of myotube differentiation (GO:0010831)2.53283441
131cardiac muscle cell proliferation (GO:0060038)2.52210225
132cardiac myofibril assembly (GO:0055003)2.51448621
133regulation of heart rate (GO:0002027)2.49371121
134cell differentiation involved in kidney development (GO:0061005)2.49137265
135cell-substrate adherens junction assembly (GO:0007045)2.48636772
136focal adhesion assembly (GO:0048041)2.48636772
137locomotory exploration behavior (GO:0035641)2.48113045
138oxaloacetate metabolic process (GO:0006107)2.47026143
139negative regulation of protein localization to cell surface (GO:2000009)2.46380011
140platelet-derived growth factor receptor signaling pathway (GO:0048008)2.46025052
141ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.45885608
142regulation of vascular permeability (GO:0043114)2.45764983
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.45175759
144cardiac conduction (GO:0061337)2.44617760
145regulation of Rac protein signal transduction (GO:0035020)2.42598950
146syncytium formation (GO:0006949)2.41766973
147regulation of short-term neuronal synaptic plasticity (GO:0048172)2.41141841
148protein targeting to plasma membrane (GO:0072661)2.41101675
149branching involved in salivary gland morphogenesis (GO:0060445)2.40457451
150negative regulation of vascular permeability (GO:0043116)2.39344299
151lymph vessel development (GO:0001945)2.39234425
152sprouting angiogenesis (GO:0002040)2.38680972
153establishment of nucleus localization (GO:0040023)2.38302718
154glutamate secretion (GO:0014047)2.35821840
155regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.35606789
156retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34076945
157regulation of alkaline phosphatase activity (GO:0010692)2.33993234
158auditory receptor cell stereocilium organization (GO:0060088)2.31355410
159glomerular filtration (GO:0003094)2.29697415
160endothelium development (GO:0003158)2.29434275
161neuromuscular process controlling balance (GO:0050885)2.29141825
162activation of protein kinase A activity (GO:0034199)2.27896750
163vocalization behavior (GO:0071625)2.27003940
164camera-type eye morphogenesis (GO:0048593)2.26429074
165cell communication involved in cardiac conduction (GO:0086065)2.24925733
166actin cytoskeleton reorganization (GO:0031532)2.24878233
167endothelial cell migration (GO:0043542)2.24207740
168sodium ion export (GO:0071436)2.23866247
169collagen fibril organization (GO:0030199)2.23096258
170axonal fasciculation (GO:0007413)2.21793179
171apoptotic cell clearance (GO:0043277)2.19683503
172diaphragm development (GO:0060539)2.19086105
173skeletal muscle organ development (GO:0060538)2.18497137
174mesodermal cell differentiation (GO:0048333)2.18327209
175positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.18032461
176positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.17338269
177substrate-dependent cell migration (GO:0006929)2.17210710
178endocytic recycling (GO:0032456)2.16822627
179sarcomere organization (GO:0045214)2.15481642
180neuron recognition (GO:0008038)2.15366459
181positive regulation of adherens junction organization (GO:1903393)2.13766047
182regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.13365702
183regulation of corticosteroid hormone secretion (GO:2000846)2.13210709
184semaphorin-plexin signaling pathway (GO:0071526)2.12159332
185glomerular visceral epithelial cell development (GO:0072015)15.1132244
186glomerular epithelial cell development (GO:0072310)13.4422790
187glomerular basement membrane development (GO:0032836)11.8787693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.05180739
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.03826035
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60741159
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47028075
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47028075
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38526002
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32986492
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23424052
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21919856
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17590800
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16775340
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15710112
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.12133199
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08086561
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.06429981
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.00437990
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00064110
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98605565
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.93743973
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90692746
21* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.88575032
22* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.86990490
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.85871844
24DROSHA_22980978_ChIP-Seq_HELA_Human1.85111173
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.82977964
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80998264
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.77321161
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.76899545
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76193323
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.75604895
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.75128244
32* EZH2_27294783_Chip-Seq_ESCs_Mouse1.74874086
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70170985
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59690194
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59353573
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58168187
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56976386
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56602554
39* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52800199
40CLOCK_20551151_ChIP-Seq_293T_Human1.51981787
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49028671
42* KDM2B_26808549_Chip-Seq_K562_Human1.48265650
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46310657
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44566717
45GBX2_23144817_ChIP-Seq_PC3_Human1.44053335
46* CTCF_27219007_Chip-Seq_Bcells_Human1.43667027
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40709024
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40480525
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38151953
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.36877282
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36214388
52AHR_22903824_ChIP-Seq_MCF-7_Human1.35617530
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35365092
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34730391
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34118075
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28760589
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28595760
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27535319
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27238788
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.24417823
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24288628
62* SMAD3_21741376_ChIP-Seq_HESCs_Human1.23320811
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.22470145
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.20022944
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18544895
66RXR_22108803_ChIP-Seq_LS180_Human1.16157767
67TP53_16413492_ChIP-PET_HCT116_Human1.15968423
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15904262
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.15412652
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14366791
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13390246
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.12549378
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11926025
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11062694
75RACK7_27058665_Chip-Seq_MCF-7_Human1.10883364
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09978786
77* RXR_22158963_ChIP-Seq_LIVER_Mouse1.09705928
78* GATA2_21666600_ChIP-Seq_HMVEC_Human1.09239414
79* TBX20_22080862_ChIP-Seq_HEART_Mouse1.07601966
80* TBX20_22328084_ChIP-Seq_HEART_Mouse1.07601966
81SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06485156
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.06374384
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05901981
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05115408
85* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04892929
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04383045
87* LXR_22158963_ChIP-Seq_LIVER_Mouse1.03342737
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01705288
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01640164
90* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01125668
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.01081747
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.00852134
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00644437
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00448854
95TP53_18474530_ChIP-ChIP_U2OS_Human1.00299191
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00123774
97* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98882305
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98332048
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98329679
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98291834
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97951555
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.97518314
103CJUN_26792858_Chip-Seq_BT549_Human0.97484802
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.96990600
105* SMC4_20622854_ChIP-Seq_HELA_Human0.96788136
106* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96610294
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.96484326
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96327682
109* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96302261
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95991180
111ZNF263_19887448_ChIP-Seq_K562_Human0.95451422
112* TP53_23651856_ChIP-Seq_MEFs_Mouse0.95232868
113* LXR_22292898_ChIP-Seq_THP-1_Human0.93891276
114MYC_27129775_Chip-Seq_CORNEA_Mouse0.93544571
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.93151377
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92728058
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91925938
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91123091
119* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90501239
120* SMAD4_21799915_ChIP-Seq_A2780_Human0.90388286
121AR_19668381_ChIP-Seq_PC3_Human0.90156218
122* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89511318
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88902154
124* ISL1_27105846_Chip-Seq_CPCs_Mouse0.88715781
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88711603
126* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88603241
127KDM2B_26808549_Chip-Seq_DND41_Human0.88539901
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87655031
129* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86751209
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86095279
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85676768
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.85536531
133TCF7_22412390_ChIP-Seq_EML_Mouse0.83260005
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.82326538
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81096236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology4.96258690
2MP0004859_abnormal_synaptic_plasticity4.28576662
3MP0004084_abnormal_cardiac_muscle3.85495177
4MP0004272_abnormal_basement_membrane3.61199643
5MP0010368_abnormal_lymphatic_system3.19323078
6MP0004036_abnormal_muscle_relaxation2.85711588
7MP0005503_abnormal_tendon_morphology2.57850391
8MP0000751_myopathy2.51401845
9MP0005670_abnormal_white_adipose2.42381656
10MP0001879_abnormal_lymphatic_vessel2.41267547
11MP0004510_myositis2.19340300
12MP0002332_abnormal_exercise_endurance2.12721385
13MP0002837_dystrophic_cardiac_calcinosis2.06450952
14MP0003283_abnormal_digestive_organ1.92688585
15MP0008438_abnormal_cutaneous_collagen1.89764552
16MP0005451_abnormal_body_composition1.85647294
17MP0009384_cardiac_valve_regurgitation1.85575636
18MP0003705_abnormal_hypodermis_morpholog1.83593460
19MP0000013_abnormal_adipose_tissue1.83062044
20MP0003279_aneurysm1.79296797
21MP0000537_abnormal_urethra_morphology1.79108904
22MP0005167_abnormal_blood-brain_barrier1.78141933
23MP0000534_abnormal_ureter_morphology1.77483568
24MP0009780_abnormal_chondrocyte_physiolo1.75599154
25MP0000747_muscle_weakness1.71449906
26* MP0003635_abnormal_synaptic_transmissio1.69658197
27MP0000230_abnormal_systemic_arterial1.68357082
28MP0004233_abnormal_muscle_weight1.64550636
29MP0006138_congestive_heart_failure1.62260583
30MP0003942_abnormal_urinary_system1.61117047
31MP0005620_abnormal_muscle_contractility1.55292940
32MP0003091_abnormal_cell_migration1.53853003
33MP0000749_muscle_degeneration1.53402289
34MP0004087_abnormal_muscle_fiber1.53287075
35MP0004484_altered_response_of1.49674636
36MP0004215_abnormal_myocardial_fiber1.49133786
37MP0003566_abnormal_cell_adhesion1.47235677
38MP0008775_abnormal_heart_ventricle1.46168897
39MP0002972_abnormal_cardiac_muscle1.46030033
40MP0005666_abnormal_adipose_tissue1.45927661
41MP0002295_abnormal_pulmonary_circulatio1.45722228
42MP0008961_abnormal_basal_metabolism1.43307747
43MP0010030_abnormal_orbit_morphology1.43304437
44MP0002127_abnormal_cardiovascular_syste1.42635554
45MP0005275_abnormal_skin_tensile1.40268349
46MP0005385_cardiovascular_system_phenoty1.39253123
47MP0001544_abnormal_cardiovascular_syste1.39253123
48MP0003879_abnormal_hair_cell1.36884785
49MP0005330_cardiomyopathy1.32262026
50* MP0002063_abnormal_learning/memory/cond1.32078390
51MP0002269_muscular_atrophy1.29888586
52MP0002971_abnormal_brown_adipose1.29190925
53MP0003137_abnormal_impulse_conducting1.25887767
54MP0004130_abnormal_muscle_cell1.25123650
55MP0005187_abnormal_penis_morphology1.21819220
56MP0001958_emphysema1.19735527
57MP0004270_analgesia1.19393906
58MP0002822_catalepsy1.18109313
59MP0010630_abnormal_cardiac_muscle1.15306485
60MP0001661_extended_life_span1.15058054
61MP0004085_abnormal_heartbeat1.14055538
62MP0009745_abnormal_behavioral_response1.13398561
63MP0002128_abnormal_blood_circulation1.12591957
64MP0001299_abnormal_eye_distance/1.10205724
65MP0002108_abnormal_muscle_morphology1.10175802
66MP0000767_abnormal_smooth_muscle1.09834011
67MP0000003_abnormal_adipose_tissue1.09316264
68MP0003385_abnormal_body_wall1.09027457
69MP0003646_muscle_fatigue1.07078856
70MP0004858_abnormal_nervous_system1.06488085
71MP0002135_abnormal_kidney_morphology1.06288213
72MP0000759_abnormal_skeletal_muscle1.05638496
73MP0004185_abnormal_adipocyte_glucose1.04452844
74MP0005369_muscle_phenotype1.03269057
75MP0006036_abnormal_mitochondrial_physio1.01507352
76MP0002106_abnormal_muscle_physiology1.00756667
77MP0004145_abnormal_muscle_electrophysio0.99188376
78MP0002136_abnormal_kidney_physiology0.99133376
79MP0005409_darkened_coat_color0.96790768
80MP0005165_increased_susceptibility_to0.94655500
81MP0002064_seizures0.93178024
82MP0002896_abnormal_bone_mineralization0.92999172
83MP0002090_abnormal_vision0.91911514
84MP0003941_abnormal_skin_development0.90042603
85MP0001614_abnormal_blood_vessel0.89557279
86MP0005423_abnormal_somatic_nervous0.89013966
87MP0001486_abnormal_startle_reflex0.88845886
88MP0003115_abnormal_respiratory_system0.86650750
89MP0005595_abnormal_vascular_smooth0.86575048
90MP0005508_abnormal_skeleton_morphology0.86262563
91MP0001501_abnormal_sleep_pattern0.86059430
92MP0003950_abnormal_plasma_membrane0.85596002
93MP0003075_altered_response_to0.84527743
94MP0003828_pulmonary_edema0.83574253
95MP0000750_abnormal_muscle_regeneration0.82988840
96MP0002909_abnormal_adrenal_gland0.82979891
97MP0001440_abnormal_grooming_behavior0.82855515
98MP0000678_abnormal_parathyroid_gland0.79602104
99MP0009643_abnormal_urine_homeostasis0.79076133
100MP0005375_adipose_tissue_phenotype0.78136773
101MP0000733_abnormal_muscle_development0.78060794
102MP0002925_abnormal_cardiovascular_devel0.77976491
103MP0003880_abnormal_central_pattern0.77766543
104MP0003329_amyloid_beta_deposits0.77131600
105MP0000163_abnormal_cartilage_morphology0.77121454
106MP0005197_abnormal_uvea_morphology0.76740896
107MP0001784_abnormal_fluid_regulation0.76440313
108MP0003690_abnormal_glial_cell0.75845157
109MP0003045_fibrosis0.75546603
110MP0005535_abnormal_body_temperature0.72948581
111MP0002234_abnormal_pharynx_morphology0.72826721
112* MP0002572_abnormal_emotion/affect_behav0.72211794
113MP0009250_abnormal_appendicular_skeleto0.72088894
114MP0000579_abnormal_nail_morphology0.71294074
115MP0008569_lethality_at_weaning0.69879059
116MP0005266_abnormal_metabolism0.69445157
117MP0000266_abnormal_heart_morphology0.68020404
118MP0005166_decreased_susceptibility_to0.67076136
119MP0002734_abnormal_mechanical_nocicepti0.66372491
120MP0002272_abnormal_nervous_system0.62872486
121MP0008874_decreased_physiological_sensi0.61526647
122MP0002933_joint_inflammation0.60678966
123MP0001502_abnormal_circadian_rhythm0.59908677
124MP0002876_abnormal_thyroid_physiology0.57475177
125MP0009840_abnormal_foam_cell0.53535580
126MP0000343_altered_response_to0.53172489
127MP0000249_abnormal_blood_vessel0.51531428
128MP0002078_abnormal_glucose_homeostasis0.49127569

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)8.95644316
2Focal segmental glomerulosclerosis (HP:0000097)8.14478268
3Muscle fiber inclusion bodies (HP:0100299)7.97425739
4Nemaline bodies (HP:0003798)7.84036544
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.74821689
6Glomerulosclerosis (HP:0000096)6.21635070
7Hypoalbuminemia (HP:0003073)6.13685562
8Abnormal albumin level (HP:0012116)6.13685562
9Nephritis (HP:0000123)4.37838777
10Stage 5 chronic kidney disease (HP:0003774)4.34252156
11Distal lower limb muscle weakness (HP:0009053)4.27500291
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.26765956
13Myopathic facies (HP:0002058)4.22349373
14Round ear (HP:0100830)4.14869350
15Neck muscle weakness (HP:0000467)3.94341832
16Distal arthrogryposis (HP:0005684)3.94126958
17Rapidly progressive (HP:0003678)3.77791256
18Rhabdomyolysis (HP:0003201)3.76505182
19Myoglobinuria (HP:0002913)3.76429994
20Glomerulonephritis (HP:0000099)3.68003781
21Lymphangioma (HP:0100764)3.51793125
22Ulnar deviation of the wrist (HP:0003049)3.24306142
23Rimmed vacuoles (HP:0003805)3.13745602
24Nephrotic syndrome (HP:0000100)3.13567859
25Tubular atrophy (HP:0000092)3.13068069
26EMG: neuropathic changes (HP:0003445)3.11565264
27Broad metatarsal (HP:0001783)3.10839459
28Sudden death (HP:0001699)3.04550876
29Muscle stiffness (HP:0003552)3.03834512
30Frequent falls (HP:0002359)3.00723779
31Nonprogressive disorder (HP:0003680)2.97506587
32Lipoatrophy (HP:0100578)2.96165036
33Hypoproteinemia (HP:0003075)2.93669148
34Protrusio acetabuli (HP:0003179)2.93127752
35Muscle fiber splitting (HP:0003555)2.86341380
36Spinal rigidity (HP:0003306)2.83995059
37Dilated cardiomyopathy (HP:0001644)2.81664087
38Hip contracture (HP:0003273)2.78779185
39Hyporeflexia of lower limbs (HP:0002600)2.75479427
40Ankle contracture (HP:0006466)2.75355912
41Shallow orbits (HP:0000586)2.75167517
42Neonatal respiratory distress (HP:0002643)2.73805250
43Areflexia of lower limbs (HP:0002522)2.68607652
44Aortic aneurysm (HP:0004942)2.68294110
45Exercise-induced myalgia (HP:0003738)2.65171299
46Increased connective tissue (HP:0009025)2.56894052
47Abnormality of the foot musculature (HP:0001436)2.55371639
48Difficulty running (HP:0009046)2.50495953
49Calcaneovalgus deformity (HP:0001848)2.49727228
50Bundle branch block (HP:0011710)2.48748576
51Foot dorsiflexor weakness (HP:0009027)2.46464921
52Generalized muscle weakness (HP:0003324)2.46235155
53Proteinuria (HP:0000093)2.46127731
54Right ventricular cardiomyopathy (HP:0011663)2.43944840
55Type 1 muscle fiber predominance (HP:0003803)2.43650356
56Metaphyseal dysplasia (HP:0100255)2.43465372
57Premature rupture of membranes (HP:0001788)2.42462267
58Bulbar palsy (HP:0001283)2.41738979
59Coronal craniosynostosis (HP:0004440)2.38866120
60Slender build (HP:0001533)2.38053715
61Cerebral aneurysm (HP:0004944)2.37076155
62Increased variability in muscle fiber diameter (HP:0003557)2.36581608
63Corneal erosion (HP:0200020)2.28619471
64Myokymia (HP:0002411)2.27101795
65Difficulty climbing stairs (HP:0003551)2.24573708
66Aortic dissection (HP:0002647)2.21837446
67Exercise-induced muscle cramps (HP:0003710)2.19871535
68Deformed tarsal bones (HP:0008119)2.18561620
69Abnormality of the calf musculature (HP:0001430)2.17366629
70Atrial fibrillation (HP:0005110)2.15983306
71Aneurysm (HP:0002617)2.14388473
72Limited hip movement (HP:0008800)2.13836213
73Gowers sign (HP:0003391)2.11822885
74Obstructive sleep apnea (HP:0002870)2.11763808
75Polar cataract (HP:0010696)2.08117251
76Turricephaly (HP:0000262)2.07002347
77Abnormality of skeletal muscle fiber size (HP:0012084)2.06937446
78Hematuria (HP:0000790)2.05880476
79Visceral angiomatosis (HP:0100761)2.05713941
80Primary atrial arrhythmia (HP:0001692)2.05289580
81Calf muscle hypertrophy (HP:0008981)2.03217991
82Heart block (HP:0012722)2.00143881
83Malignant hyperthermia (HP:0002047)1.98147925
84Abnormal atrioventricular conduction (HP:0005150)1.97575174
85Venous insufficiency (HP:0005293)1.96428073
86Metaphyseal cupping (HP:0003021)1.96023572
87Distal lower limb amyotrophy (HP:0008944)1.95221200
88Atrioventricular block (HP:0001678)1.95089411
89Ventricular fibrillation (HP:0001663)1.94574338
90Limb-girdle muscle atrophy (HP:0003797)1.94148944
91EMG: myopathic abnormalities (HP:0003458)1.93514305
92Vascular tortuosity (HP:0004948)1.93280598
93Supraventricular arrhythmia (HP:0005115)1.93112027
94Hyperkalemia (HP:0002153)1.92830941
95Prolonged QT interval (HP:0001657)1.90809881
96Mildly elevated creatine phosphokinase (HP:0008180)1.90704859
97Muscle hypertrophy of the lower extremities (HP:0008968)1.90651036
98Knee flexion contracture (HP:0006380)1.90638353
99Muscular dystrophy (HP:0003560)1.89408365
100Ventricular tachycardia (HP:0004756)1.89360460
101Pterygium (HP:0001059)1.88924370
102Lower limb amyotrophy (HP:0007210)1.88866844
103Supraventricular tachycardia (HP:0004755)1.88721714
104Focal motor seizures (HP:0011153)1.87672298
105Hemangiomatosis (HP:0007461)1.87038515
106Arterial tortuosity (HP:0005116)1.84380708
107Subaortic stenosis (HP:0001682)1.84368957
108Abnormality of the left ventricular outflow tract (HP:0011103)1.84368957
109Syncope (HP:0001279)1.81934097
110Distal upper limb amyotrophy (HP:0007149)1.81486120
111Upper limb amyotrophy (HP:0009129)1.81486120
112Myotonia (HP:0002486)1.81414831
113Absent phalangeal crease (HP:0006109)1.81246331
114Increased circulating renin level (HP:0000848)1.81177804
115Waddling gait (HP:0002515)1.79805076
116Proximal amyotrophy (HP:0007126)1.79496014
117Oligomenorrhea (HP:0000876)1.79472314
118Ragged-red muscle fibers (HP:0003200)1.79159757
119Venous abnormality (HP:0002624)1.77933772
120Polycythemia (HP:0001901)1.76958332
121Weak cry (HP:0001612)1.76347674
122Abnormal finger flexion creases (HP:0006143)1.76083375
123Exostoses (HP:0100777)1.75947160
124Overgrowth (HP:0001548)1.75586107
125Abnormal EKG (HP:0003115)1.75419120
126Deep venous thrombosis (HP:0002625)1.74780509
127Persistence of primary teeth (HP:0006335)1.74545361
128Hypoplasia of the iris (HP:0007676)1.70484407
129Tubulointerstitial fibrosis (HP:0005576)1.68793327
130Ventricular arrhythmia (HP:0004308)1.66266505
131Hypoplastic ischia (HP:0003175)1.66109444
132Atrophic scars (HP:0001075)1.65558821
133Bladder diverticulum (HP:0000015)1.64797924
134Abnormality of the shoulder girdle musculature (HP:0001435)1.64653321
135Fetal akinesia sequence (HP:0001989)1.64232019
136Renal duplication (HP:0000075)1.63752430
137Asymmetric septal hypertrophy (HP:0001670)1.61786923
138Steppage gait (HP:0003376)1.59633248
139Respiratory insufficiency due to muscle weakness (HP:0002747)1.59591188
140Wrist flexion contracture (HP:0001239)1.58883821
141Abnormal tarsal ossification (HP:0008369)1.57680713
142Bronchomalacia (HP:0002780)1.56783640
143Buphthalmos (HP:0000557)1.54727607
144Scapular winging (HP:0003691)1.54562557
145Hematochezia (HP:0002573)1.54372579
146Limb-girdle muscle weakness (HP:0003325)1.52830810
147Fatigable weakness (HP:0003473)1.50471960
148Abnormality of the neuromuscular junction (HP:0003398)1.50471960
149Ankle clonus (HP:0011448)1.50112079
150Sudden cardiac death (HP:0001645)1.49740029
151Dysmetric saccades (HP:0000641)1.49310225
152Stridor (HP:0010307)1.44317809
153Abnormality of the calcaneus (HP:0008364)1.43193808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.62863437
2EPHA42.95138930
3TTN2.57846879
4TRIB32.55567958
5WNK42.55521027
6TIE12.55386800
7NTRK32.54478163
8MYLK2.44057243
9PRKD32.27467406
10PAK42.01396197
11OXSR12.00789840
12PDGFRA1.95276116
13DMPK1.85112125
14MAP3K71.74880213
15NTRK11.70251460
16KSR21.66847827
17TGFBR21.65207040
18RIPK11.64561740
19LATS21.62458206
20STK391.59092103
21PAK31.56146003
22PIK3CG1.52605525
23PAK61.48358608
24PINK11.48194868
25MAP3K91.47286656
26PHKG11.46725101
27PHKG21.46725101
28LATS11.46547697
29FER1.45802868
30PRPF4B1.41906994
31DAPK21.40488669
32DDR21.39860701
33PTK2B1.39503740
34TRPM71.31892106
35MAPKAPK31.30904928
36LMTK21.26383949
37CAMK2B1.26055134
38PRKCH1.21797099
39ROCK11.17453060
40CAMKK11.17126862
41STK381.14506863
42LIMK11.09513426
43MARK21.08053022
44MUSK1.07649252
45EPHB11.06013976
46TYRO31.04963175
47EEF2K1.04493738
48CAMK2G1.02014004
49PKN21.01650756
50MAPK71.00244455
51OBSCN0.99947283
52TAOK10.99518300
53CDK190.98570128
54MAP3K20.98553735
55BMX0.98140603
56PRKAA20.95979703
57MAP2K30.95725662
58KDR0.92945815
59NME10.91373565
60CDK50.89530148
61PAK20.86702718
62MAP2K10.86519045
63CAMK10.85173999
64MINK10.84559108
65PTK20.84185929
66ICK0.83024451
67MAP3K40.82649442
68MAP3K130.82573069
69PDPK10.82279950
70NEK90.81042309
71NEK10.80282471
72PTK60.79462978
73CAMK2D0.78703234
74MAP3K60.78045425
75TESK10.77698861
76ARAF0.76600786
77SIK10.75862980
78WNK10.75700535
79PRKAA10.75331155
80PRKD10.75322223
81RET0.74424038
82PDK20.72886287
83MAPK40.72526155
84KSR10.72207313
85PDGFRB0.69300958
86MOS0.67886489
87MAP2K60.67680993
88UHMK10.65846001
89PRKCE0.63479694
90CAMK40.63261301
91PRKD20.63181717
92PKN10.62952049
93PRKG20.62615228
94FGFR10.62390699
95MAP3K10.62008899
96CDK150.60929195
97ERN10.60553631
98MAPK120.60205523
99PDK10.59715571
100PIK3CA0.58925553
101CAMK1G0.58202342
102CDK180.57241872
103EPHA30.56001299
104SGK2230.55623081
105SGK4940.55623081
106CAMK2A0.55435703
107CDK140.55145732
108STK110.54809259
109MAP2K40.54523659
110MARK10.53813508
111ROCK20.53802411
112CDC42BPA0.53464020
113FES0.52971941
114CDK11A0.52178601
115DAPK30.51383166
116AKT20.51044281
117SGK30.49807271
118SIK20.49545925
119JAK10.49278568
120RPS6KA20.49217802
121SGK20.47980793
122FGFR40.47893108
123PLK20.47468125
124FGFR20.46666656
125FYN0.46087798
126PRKG10.45972610
127NTRK20.45765627
128SRC0.45383891
129PDK40.45075812
130PDK30.45075812
131MAPK100.43232180
132SGK10.42615416
133GRK50.41634450
134RPS6KA30.41052405
135MST1R0.40897626
136CAMKK20.40728289
137MTOR0.39218717
138MAPK110.39177998
139MET0.36868700
140RPS6KC10.34003796
141RPS6KL10.34003796

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.63937326
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.50515255
3Dilated cardiomyopathy_Homo sapiens_hsa054142.41057181
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28420935
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.16435629
6Focal adhesion_Homo sapiens_hsa045101.94207798
7Axon guidance_Homo sapiens_hsa043601.94089635
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83594682
9Renin-angiotensin system_Homo sapiens_hsa046141.75612419
10Protein digestion and absorption_Homo sapiens_hsa049741.69923458
11Arginine biosynthesis_Homo sapiens_hsa002201.67076048
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66476985
13Circadian entrainment_Homo sapiens_hsa047131.65520464
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64392073
15Gastric acid secretion_Homo sapiens_hsa049711.62450925
16Amoebiasis_Homo sapiens_hsa051461.60484014
17Long-term potentiation_Homo sapiens_hsa047201.55862983
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55684264
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52943167
20Phenylalanine metabolism_Homo sapiens_hsa003601.47014957
21Arginine and proline metabolism_Homo sapiens_hsa003301.46336807
22Oxytocin signaling pathway_Homo sapiens_hsa049211.44393410
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44303706
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43175910
25Renin secretion_Homo sapiens_hsa049241.42958443
26Olfactory transduction_Homo sapiens_hsa047401.41676950
27Salivary secretion_Homo sapiens_hsa049701.38807525
28Amphetamine addiction_Homo sapiens_hsa050311.37837930
29Insulin secretion_Homo sapiens_hsa049111.35989028
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.26145935
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25560052
32PPAR signaling pathway_Homo sapiens_hsa033201.22700915
33Synaptic vesicle cycle_Homo sapiens_hsa047211.22697341
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21209046
35Glutamatergic synapse_Homo sapiens_hsa047241.20447146
36Cholinergic synapse_Homo sapiens_hsa047251.20248137
37Small cell lung cancer_Homo sapiens_hsa052221.19298153
38Morphine addiction_Homo sapiens_hsa050321.18803039
39Calcium signaling pathway_Homo sapiens_hsa040201.17639502
40Proteoglycans in cancer_Homo sapiens_hsa052051.17101859
41cAMP signaling pathway_Homo sapiens_hsa040241.16209038
42GABAergic synapse_Homo sapiens_hsa047271.15704706
43Adherens junction_Homo sapiens_hsa045201.15238195
44Gap junction_Homo sapiens_hsa045401.15235482
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14816780
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13666231
47GnRH signaling pathway_Homo sapiens_hsa049121.13473969
48AMPK signaling pathway_Homo sapiens_hsa041521.09640411
49Glioma_Homo sapiens_hsa052141.08679856
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07679115
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07152834
52Rap1 signaling pathway_Homo sapiens_hsa040151.06913798
53Dopaminergic synapse_Homo sapiens_hsa047281.06546553
54Nicotine addiction_Homo sapiens_hsa050331.06352689
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05408857
56Fatty acid degradation_Homo sapiens_hsa000711.04886933
57Carbon metabolism_Homo sapiens_hsa012001.01086246
58Cocaine addiction_Homo sapiens_hsa050300.98740308
59VEGF signaling pathway_Homo sapiens_hsa043700.98416060
60Tight junction_Homo sapiens_hsa045300.96395822
61Estrogen signaling pathway_Homo sapiens_hsa049150.94987835
62Cardiac muscle contraction_Homo sapiens_hsa042600.93330606
63Nitrogen metabolism_Homo sapiens_hsa009100.92660903
64Melanogenesis_Homo sapiens_hsa049160.92649527
65Histidine metabolism_Homo sapiens_hsa003400.92049652
66Dorso-ventral axis formation_Homo sapiens_hsa043200.89550838
67Renal cell carcinoma_Homo sapiens_hsa052110.88731045
68Fructose and mannose metabolism_Homo sapiens_hsa000510.88538600
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87267209
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87182934
71Bladder cancer_Homo sapiens_hsa052190.87085270
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84951148
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.84563533
74Long-term depression_Homo sapiens_hsa047300.81276106
75Type II diabetes mellitus_Homo sapiens_hsa049300.79696844
76Thyroid hormone synthesis_Homo sapiens_hsa049180.78507014
77Platelet activation_Homo sapiens_hsa046110.76374820
78mTOR signaling pathway_Homo sapiens_hsa041500.75713302
79Pyruvate metabolism_Homo sapiens_hsa006200.74357850
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73764088
81Pentose phosphate pathway_Homo sapiens_hsa000300.73630642
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72903403
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71885194
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71283669
85Hippo signaling pathway_Homo sapiens_hsa043900.71220628
86Ovarian steroidogenesis_Homo sapiens_hsa049130.70474674
87Prion diseases_Homo sapiens_hsa050200.69314976
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69233253
89Ras signaling pathway_Homo sapiens_hsa040140.66301959
90ErbB signaling pathway_Homo sapiens_hsa040120.66292474
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66012049
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65447790
93Glucagon signaling pathway_Homo sapiens_hsa049220.65410572
94Endocytosis_Homo sapiens_hsa041440.64195055
95Bile secretion_Homo sapiens_hsa049760.63710545
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.63669959
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63629964
98Taste transduction_Homo sapiens_hsa047420.61732137
99Pancreatic secretion_Homo sapiens_hsa049720.59698932
100Serotonergic synapse_Homo sapiens_hsa047260.59224257
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58853461
102MAPK signaling pathway_Homo sapiens_hsa040100.57423275
103Insulin resistance_Homo sapiens_hsa049310.56938044
104Starch and sucrose metabolism_Homo sapiens_hsa005000.55710852
105beta-Alanine metabolism_Homo sapiens_hsa004100.54610276
106Wnt signaling pathway_Homo sapiens_hsa043100.54098857
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.53632967
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53044307
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.52501007
110Pancreatic cancer_Homo sapiens_hsa052120.51794905
111Circadian rhythm_Homo sapiens_hsa047100.51767742
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.51487413
113Viral myocarditis_Homo sapiens_hsa054160.51398025
114Choline metabolism in cancer_Homo sapiens_hsa052310.51018451
115Insulin signaling pathway_Homo sapiens_hsa049100.50721839
116HIF-1 signaling pathway_Homo sapiens_hsa040660.49628502
117Pathways in cancer_Homo sapiens_hsa052000.48304664
118Tyrosine metabolism_Homo sapiens_hsa003500.47905423
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47153784
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46176078
121Complement and coagulation cascades_Homo sapiens_hsa046100.43687991
122Fatty acid metabolism_Homo sapiens_hsa012120.43639558
123Biosynthesis of amino acids_Homo sapiens_hsa012300.42437372
124Galactose metabolism_Homo sapiens_hsa000520.40438780
125Propanoate metabolism_Homo sapiens_hsa006400.39435510
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36819882
127Tryptophan metabolism_Homo sapiens_hsa003800.34048372

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