SYNRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.18583202
2negative regulation of cell killing (GO:0031342)6.17846922
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.17846922
4negative T cell selection (GO:0043383)5.72650321
5regulation of B cell receptor signaling pathway (GO:0050855)5.71721389
6negative thymic T cell selection (GO:0045060)5.47249371
7regulation of gamma-delta T cell differentiation (GO:0045586)5.03198046
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02003218
9positive T cell selection (GO:0043368)4.95874349
10regulation of gamma-delta T cell activation (GO:0046643)4.88490432
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.78869909
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.66615795
13histone H3-K4 trimethylation (GO:0080182)4.56390397
14axon ensheathment in central nervous system (GO:0032291)4.44990018
15central nervous system myelination (GO:0022010)4.44990018
16antigen processing and presentation of endogenous antigen (GO:0019883)4.44520934
17cellular response to interleukin-15 (GO:0071350)4.35113871
18positive thymic T cell selection (GO:0045059)4.33825002
19response to interleukin-15 (GO:0070672)4.31945371
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.27929756
21neuron cell-cell adhesion (GO:0007158)4.26384079
22T cell selection (GO:0045058)4.23336976
23positive regulation of granulocyte differentiation (GO:0030854)4.21109771
24negative regulation of T cell mediated immunity (GO:0002710)4.02219123
25tolerance induction (GO:0002507)3.96405680
26thymic T cell selection (GO:0045061)3.95034410
27B cell receptor signaling pathway (GO:0050853)3.92730947
28interferon-gamma production (GO:0032609)3.81315645
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.80092706
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.76350000
31locomotory exploration behavior (GO:0035641)3.76177876
32histone H3-K36 demethylation (GO:0070544)3.75785437
33T cell migration (GO:0072678)3.65981725
34presynaptic membrane assembly (GO:0097105)3.60422807
35negative regulation of protein localization to cell surface (GO:2000009)3.55614168
36leukocyte aggregation (GO:0070486)3.55514334
37transmission of nerve impulse (GO:0019226)3.55083303
38regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50147035
39phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.49255592
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.49250376
41neuron recognition (GO:0008038)3.47461914
42neuronal action potential propagation (GO:0019227)3.46494751
43presynaptic membrane organization (GO:0097090)3.44309339
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.43175983
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42586107
46regulation of isotype switching to IgG isotypes (GO:0048302)3.36847127
47regulation of vesicle fusion (GO:0031338)3.34953662
48regulation of B cell differentiation (GO:0045577)3.32101851
49vocalization behavior (GO:0071625)3.32038092
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.31492374
51synaptic vesicle maturation (GO:0016188)3.29294706
52regulation of alpha-beta T cell proliferation (GO:0046640)3.27349721
53negative regulation of neurotransmitter transport (GO:0051589)3.26791348
54dendritic spine morphogenesis (GO:0060997)3.24718973
55regulation of T cell tolerance induction (GO:0002664)3.21507088
56myelination (GO:0042552)3.18743443
57negative regulation of leukocyte mediated immunity (GO:0002704)3.15614741
58axon ensheathment (GO:0008366)3.15089878
59ensheathment of neurons (GO:0007272)3.15089878
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15051605
61antigen receptor-mediated signaling pathway (GO:0050851)3.14997288
62axonal fasciculation (GO:0007413)3.14811172
63chemosensory behavior (GO:0007635)3.14539165
64synaptic vesicle exocytosis (GO:0016079)3.11761272
65peptidyl-lysine trimethylation (GO:0018023)3.11537952
66long-chain fatty acid biosynthetic process (GO:0042759)3.10839108
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.10614547
68protein localization to synapse (GO:0035418)3.09166782
69negative regulation of neurotransmitter secretion (GO:0046929)3.07689488
70nerve growth factor signaling pathway (GO:0038180)3.07447683
71positive regulation of B cell differentiation (GO:0045579)3.05494454
72glutamate receptor signaling pathway (GO:0007215)3.04641232
73regulation of T cell mediated cytotoxicity (GO:0001914)3.03925876
74L-amino acid import (GO:0043092)3.03769607
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.01715415
76neuronal ion channel clustering (GO:0045161)3.00571115
77regulation of glutamate receptor signaling pathway (GO:1900449)3.00405828
78regulation of granulocyte differentiation (GO:0030852)2.99955399
79mast cell activation (GO:0045576)2.99364347
80regulation of regulatory T cell differentiation (GO:0045589)2.99014584
81protein targeting to Golgi (GO:0000042)2.98277512
82T cell receptor signaling pathway (GO:0050852)2.98151509
83regulation of synaptic vesicle exocytosis (GO:2000300)2.97692327
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.97134578
85regulation of natural killer cell mediated immunity (GO:0002715)2.97134578
86negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95851982
87regulation of tolerance induction (GO:0002643)2.94867914
88dendrite morphogenesis (GO:0048813)2.94725231
89peptidyl-tyrosine autophosphorylation (GO:0038083)2.93465579
90exploration behavior (GO:0035640)2.90408460
91cellular extravasation (GO:0045123)2.89834436
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89099896
93layer formation in cerebral cortex (GO:0021819)2.88770948
94positive regulation of tolerance induction (GO:0002645)2.88457061
95histone H3-K4 methylation (GO:0051568)2.87379056
96Peyers patch development (GO:0048541)2.86535687
97mucosal-associated lymphoid tissue development (GO:0048537)2.86535687
98photoreceptor cell differentiation (GO:0046530)2.83553826
99eye photoreceptor cell differentiation (GO:0001754)2.83553826
100cerebellar Purkinje cell differentiation (GO:0021702)2.81301074
101B cell homeostasis (GO:0001782)2.79425590
102mating behavior (GO:0007617)2.79134372
103adult walking behavior (GO:0007628)2.78403550
104detection of calcium ion (GO:0005513)2.78260588
105oligodendrocyte differentiation (GO:0048709)2.77204827
106alpha-beta T cell differentiation (GO:0046632)2.76864635
107interkinetic nuclear migration (GO:0022027)2.76559066
108positive regulation of defense response to virus by host (GO:0002230)2.76193398
109regulation of dendritic spine morphogenesis (GO:0061001)2.76005805
110positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75526928
111regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75225769
112modulation by symbiont of host immune response (GO:0052553)2.74959357
113positive regulation by symbiont of host defense response (GO:0052509)2.74959357
114modulation by symbiont of host defense response (GO:0052031)2.74959357
115modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74959357
116modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74959357
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.74959357
118T cell homeostasis (GO:0043029)2.73539249
119histone H3-K9 modification (GO:0061647)2.73394827
120neuron-neuron synaptic transmission (GO:0007270)2.73128194
121response to type I interferon (GO:0034340)2.72300706
122positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72286892
123long-term memory (GO:0007616)2.71084983
124T cell costimulation (GO:0031295)2.70329285
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68687551
126glutamate secretion (GO:0014047)2.68538198
127negative regulation of axon extension (GO:0030517)2.68404553
128cellular response to ethanol (GO:0071361)2.68396695
129positive regulation of humoral immune response (GO:0002922)2.67574375
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67235358
131synaptic transmission, glutamatergic (GO:0035249)2.67181369
132lymphocyte costimulation (GO:0031294)2.66702288
133regulation of leukocyte mediated cytotoxicity (GO:0001910)2.66502682
134negative regulation of adaptive immune response (GO:0002820)2.66499056
135type I interferon signaling pathway (GO:0060337)2.65169728
136cellular response to type I interferon (GO:0071357)2.65169728
137regulation of neuronal synaptic plasticity (GO:0048168)2.65120396
138establishment of protein localization to Golgi (GO:0072600)2.64795000
139antigen processing and presentation via MHC class Ib (GO:0002475)2.64227065
140cellular response to epinephrine stimulus (GO:0071872)2.63982906
141lymph node development (GO:0048535)2.63067557
142macrophage activation involved in immune response (GO:0002281)2.60780736
143regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59345155
144retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59285294
145regulation of cell killing (GO:0031341)2.59179540
146regulation of MHC class I biosynthetic process (GO:0045343)2.58920347
147regulation of alpha-beta T cell activation (GO:0046634)2.58461340
148protein K48-linked deubiquitination (GO:0071108)2.58184300
149negative regulation of axonogenesis (GO:0050771)2.58181224
150suckling behavior (GO:0001967)2.57856250
151protein K11-linked deubiquitination (GO:0035871)2.57594426
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56552243
153regulation of interleukin-2 biosynthetic process (GO:0045076)2.54755296
154vesicle transport along microtubule (GO:0047496)2.54612961
155T cell differentiation (GO:0030217)2.53811688
156synaptic vesicle endocytosis (GO:0048488)2.53497068
157alpha-beta T cell activation (GO:0046631)2.53490781
158negative regulation of B cell proliferation (GO:0030889)2.53070535
159regulation of mast cell activation (GO:0033003)2.53060827
160positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51575975
161cell migration in hindbrain (GO:0021535)2.51274260
162regulation of postsynaptic membrane potential (GO:0060078)2.50753083
163cellular response to monoamine stimulus (GO:0071868)2.50135487
164cellular response to catecholamine stimulus (GO:0071870)2.50135487
165positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.49922823
166mast cell degranulation (GO:0043303)2.49613888
167mast cell activation involved in immune response (GO:0002279)2.49613888
168negative regulation of inclusion body assembly (GO:0090084)2.49382820
169negative regulation of cAMP-mediated signaling (GO:0043951)2.48996650
170long-term synaptic potentiation (GO:0060291)2.48701851
171negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.48435627
172detection of other organism (GO:0098543)2.47893657
173microglial cell activation (GO:0001774)2.47584728
174positive regulation of membrane potential (GO:0045838)2.47261398
175positive regulation of synaptic transmission, GABAergic (GO:0032230)2.47215348
176response to epinephrine (GO:0071871)2.46947317
177immunoglobulin mediated immune response (GO:0016064)2.46740128
178regulation of synaptic vesicle transport (GO:1902803)2.45133708
179cerebral cortex radially oriented cell migration (GO:0021799)2.45064318
180calcium ion import (GO:0070509)2.44346982
181asymmetric protein localization (GO:0008105)2.43259839
182activated T cell proliferation (GO:0050798)2.43216007
183regulation of ARF protein signal transduction (GO:0032012)2.43133796
184regulation of dendritic spine development (GO:0060998)2.42608195
185cellular potassium ion homeostasis (GO:0030007)2.42491557
186limb bud formation (GO:0060174)2.42407626
187synapse assembly (GO:0007416)2.41464378
188membrane depolarization during action potential (GO:0086010)2.40413780
189postsynaptic membrane organization (GO:0001941)2.40103693
190apical protein localization (GO:0045176)2.39919324
191synapse organization (GO:0050808)2.39542757
192response to monoamine (GO:0071867)2.38934045
193response to catecholamine (GO:0071869)2.38934045
194membrane hyperpolarization (GO:0060081)2.37614650
195membrane depolarization (GO:0051899)2.37458967
196amino acid import (GO:0043090)2.37166519
197organelle transport along microtubule (GO:0072384)2.36241353
198fatty acid elongation (GO:0030497)2.35614681
199regulation of long-term neuronal synaptic plasticity (GO:0048169)2.35103362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.28383532
2EZH2_22144423_ChIP-Seq_EOC_Human4.89791714
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.63465336
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.36234997
5RUNX_20019798_ChIP-Seq_JUKART_Human3.34921264
6GBX2_23144817_ChIP-Seq_PC3_Human3.12027833
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67995631
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61863996
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.58166968
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54924553
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51344528
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50922521
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44952937
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44754367
15MYB_26560356_Chip-Seq_TH2_Human2.41545252
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34807667
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17415410
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17415410
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16809787
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15809500
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.15723994
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13415919
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13350889
24DROSHA_22980978_ChIP-Seq_HELA_Human2.07182708
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06748426
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05267365
27* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03185801
28REST_21632747_ChIP-Seq_MESCs_Mouse2.02509829
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00920087
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00271022
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.00165253
32SCL_19346495_ChIP-Seq_HPC-7_Human1.98459632
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97335707
34* GATA3_27048872_Chip-Seq_THYMUS_Human1.94283179
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93117714
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.91923771
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.90808667
38MYB_26560356_Chip-Seq_TH1_Human1.89095712
39TAF15_26573619_Chip-Seq_HEK293_Human1.87594806
40AR_21572438_ChIP-Seq_LNCaP_Human1.85622476
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81356352
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.80536067
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.80234370
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.74123449
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73255936
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69314521
47MAF_26560356_Chip-Seq_TH1_Human1.63805976
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58484685
49* UTX_26944678_Chip-Seq_JUKART_Human1.57299320
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54781494
51SPI1_23127762_ChIP-Seq_K562_Human1.54474197
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53618240
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53168684
54* SMAD4_21799915_ChIP-Seq_A2780_Human1.52134428
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51541574
56* GATA3_26560356_Chip-Seq_TH2_Human1.51253857
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.51022265
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50159595
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.50021701
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49283975
61VDR_24787735_ChIP-Seq_THP-1_Human1.48595495
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48346809
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.47988282
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43512048
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41746154
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39742032
67MYC_22102868_ChIP-Seq_BL_Human1.38856422
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37822015
69P300_19829295_ChIP-Seq_ESCs_Human1.37674656
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.37533841
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37408975
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35542544
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34680809
74VDR_22108803_ChIP-Seq_LS180_Human1.34641459
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.34344761
76CIITA_25753668_ChIP-Seq_RAJI_Human1.34299537
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34088210
78AHR_22903824_ChIP-Seq_MCF-7_Human1.33497566
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32627111
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32265727
81STAT3_23295773_ChIP-Seq_U87_Human1.29876039
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.29046124
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28850610
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28050394
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27536680
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26852911
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.26822028
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23902020
89* TCF4_23295773_ChIP-Seq_U87_Human1.22160682
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21681830
91MAF_26560356_Chip-Seq_TH2_Human1.21120674
92ZNF274_21170338_ChIP-Seq_K562_Hela1.20335508
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17592942
94IGF1R_20145208_ChIP-Seq_DFB_Human1.17480416
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.17331775
96* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16154547
97* SMRT_27268052_Chip-Seq_Bcells_Human1.15711550
98* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15674323
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15420153
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15419542
101SPI1_23547873_ChIP-Seq_NB4_Human1.15305936
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15121320
103FUS_26573619_Chip-Seq_HEK293_Human1.15018686
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14964897
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14668792
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14201745
107TCF7_22412390_ChIP-Seq_EML_Mouse1.13828743
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13504252
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.12327696
110VDR_24763502_ChIP-Seq_THP-1_Human1.11818382
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.10394269
112RNF2_27304074_Chip-Seq_NSC_Mouse1.09018484
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08430339
114AR_25329375_ChIP-Seq_VCAP_Human1.07826686
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07487257
116* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07469929
117RUNX2_22187159_ChIP-Seq_PCA_Human1.07303113
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.06921377
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.06883015
120TP53_16413492_ChIP-PET_HCT116_Human1.06032328
121ER_23166858_ChIP-Seq_MCF-7_Human1.04512057
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04111421
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02924363
124GATA1_19941827_ChIP-Seq_MEL_Mouse1.02726099
125RUNX1_22412390_ChIP-Seq_EML_Mouse1.02601346
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02596407
127AR_19668381_ChIP-Seq_PC3_Human1.02530940
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02268301
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01280659
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01280659
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01016680
132GATA1_22025678_ChIP-Seq_K562_Human1.00870588
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00846992
134WDR5_24793694_ChIP-Seq_LNCAP_Human1.00430805
135TP53_18474530_ChIP-ChIP_U2OS_Human0.98317270
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97523744
137* BCAT_22108803_ChIP-Seq_LS180_Human0.97511220
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97421900
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.96981512
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96592084
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96582128
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96523404
143KDM2B_26808549_Chip-Seq_REH_Human0.96293342
144KDM2B_26808549_Chip-Seq_DND41_Human0.96087795
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96068720
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95898480
147* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95863737
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.95002316
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94680617
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.94310267
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93807409
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.93752999
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92700234
154YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92599560
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92575964
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90653259
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88823653
158GATA3_26560356_Chip-Seq_TH1_Human0.87469592
159PU_27001747_Chip-Seq_BMDM_Mouse0.87274365
160MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87269065
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86482226
162* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83066020
163GATA1_19941826_ChIP-Seq_K562_Human0.79008312
164* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77111691
165TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77032726
166* FLI1_21867929_ChIP-Seq_TH2_Mouse0.76824498
167VDR_21846776_ChIP-Seq_THP-1_Human0.76114167
168NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74628850
169IRF1_19129219_ChIP-ChIP_H3396_Human0.74610659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.40242577
2MP0004859_abnormal_synaptic_plasticity4.39378474
3MP0003763_abnormal_thymus_physiology4.18774697
4MP0005671_abnormal_response_to4.09063203
5MP0004270_analgesia3.72743095
6MP0000569_abnormal_digit_pigmentation3.43154870
7MP0001835_abnormal_antigen_presentation3.41085506
8MP0001800_abnormal_humoral_immune3.38807677
9MP0003635_abnormal_synaptic_transmissio3.12976334
10MP0003724_increased_susceptibility_to3.12102077
11MP0000685_abnormal_immune_system2.96474290
12MP0001486_abnormal_startle_reflex2.72320171
13MP0009745_abnormal_behavioral_response2.72231363
14MP0001790_abnormal_immune_system2.69439617
15MP0005387_immune_system_phenotype2.69439617
16MP0002064_seizures2.66130223
17MP0003436_decreased_susceptibility_to2.65780493
18MP0005000_abnormal_immune_tolerance2.60044802
19MP0002723_abnormal_immune_serum2.58048100
20MP0005423_abnormal_somatic_nervous2.54103058
21MP0002420_abnormal_adaptive_immunity2.52788382
22MP0002272_abnormal_nervous_system2.50485488
23MP0005310_abnormal_salivary_gland2.49060209
24MP0001819_abnormal_immune_cell2.47130136
25MP0002063_abnormal_learning/memory/cond2.47088021
26MP0002452_abnormal_antigen_presenting2.42532449
27MP0000920_abnormal_myelination2.39902250
28MP0002572_abnormal_emotion/affect_behav2.30690810
29MP0002734_abnormal_mechanical_nocicepti2.26916935
30MP0009046_muscle_twitch2.26701571
31MP0003300_gastrointestinal_ulcer2.17305578
32MP0005025_abnormal_response_to2.13130540
33MP0002398_abnormal_bone_marrow2.12290733
34MP0004145_abnormal_muscle_electrophysio2.10192103
35MP0001968_abnormal_touch/_nociception2.09240118
36MP0000778_abnormal_nervous_system2.08364088
37MP0004742_abnormal_vestibular_system2.08150194
38MP0002166_altered_tumor_susceptibility2.06410913
39MP0000703_abnormal_thymus_morphology2.05869920
40MP0001440_abnormal_grooming_behavior2.04356946
41MP0000716_abnormal_immune_system2.04173765
42MP0001501_abnormal_sleep_pattern1.99574042
43MP0002405_respiratory_system_inflammati1.98366023
44MP0002419_abnormal_innate_immunity1.96505696
45MP0006082_CNS_inflammation1.95604406
46MP0005409_darkened_coat_color1.89001380
47MP0000689_abnormal_spleen_morphology1.83940201
48MP0009780_abnormal_chondrocyte_physiolo1.83274677
49MP0001873_stomach_inflammation1.80225537
50MP0002067_abnormal_sensory_capabilities1.79373772
51MP0003303_peritoneal_inflammation1.78812067
52MP0009785_altered_susceptibility_to1.78688396
53MP0004885_abnormal_endolymph1.75544111
54MP0001970_abnormal_pain_threshold1.75223544
55MP0002735_abnormal_chemical_nociception1.71020433
56MP0002722_abnormal_immune_system1.69812197
57MP0003329_amyloid_beta_deposits1.69513200
58MP0001529_abnormal_vocalization1.69496954
59MP0002733_abnormal_thermal_nociception1.69240335
60MP0005075_abnormal_melanosome_morpholog1.68469335
61MP0008569_lethality_at_weaning1.66502482
62MP0002736_abnormal_nociception_after1.63991867
63MP0003866_abnormal_defecation1.63792161
64MP0000015_abnormal_ear_pigmentation1.62922846
65MP0005551_abnormal_eye_electrophysiolog1.60895727
66MP0006276_abnormal_autonomic_nervous1.60878946
67MP0006072_abnormal_retinal_apoptosis1.59803240
68MP0010155_abnormal_intestine_physiology1.59412509
69MP0002184_abnormal_innervation1.58953154
70MP0008877_abnormal_DNA_methylation1.57831755
71MP0003787_abnormal_imprinting1.57234087
72MP0008057_abnormal_DNA_replication1.55211223
73MP0009333_abnormal_splenocyte_physiolog1.53555910
74MP0005386_behavior/neurological_phenoty1.52976433
75MP0004924_abnormal_behavior1.52976433
76MP0002882_abnormal_neuron_morphology1.52835575
77MP0000955_abnormal_spinal_cord1.52662572
78MP0002557_abnormal_social/conspecific_i1.51485508
79MP0001905_abnormal_dopamine_level1.51462539
80MP0002822_catalepsy1.51335159
81MP0002229_neurodegeneration1.50848503
82MP0004130_abnormal_muscle_cell1.50083329
83MP0003690_abnormal_glial_cell1.47469510
84MP0005645_abnormal_hypothalamus_physiol1.47223582
85MP0002429_abnormal_blood_cell1.47151695
86MP0003634_abnormal_glial_cell1.46245223
87MP0003172_abnormal_lysosome_physiology1.42358763
88MP0001485_abnormal_pinna_reflex1.38569990
89MP0004947_skin_inflammation1.37581679
90MP0002909_abnormal_adrenal_gland1.37105694
91MP0004142_abnormal_muscle_tone1.35858148
92MP0001845_abnormal_inflammatory_respons1.34476251
93MP0002138_abnormal_hepatobiliary_system1.33503809
94MP0002066_abnormal_motor_capabilities/c1.31356768
95MP0008961_abnormal_basal_metabolism1.30314287
96MP0001502_abnormal_circadian_rhythm1.30073233
97MP0002006_tumorigenesis1.26398138
98MP0004811_abnormal_neuron_physiology1.21481393
99MP0005174_abnormal_tail_pigmentation1.20517371
100MP0002148_abnormal_hypersensitivity_rea1.19311890
101MP0002837_dystrophic_cardiac_calcinosis1.18764102
102MP0005410_abnormal_fertilization1.16904337
103MP0001984_abnormal_olfaction1.15452857
104MP0002396_abnormal_hematopoietic_system1.15043319
105MP0005379_endocrine/exocrine_gland_phen1.14909254
106MP0003136_yellow_coat_color1.13195293
107MP0005464_abnormal_platelet_physiology1.11851323
108MP0001348_abnormal_lacrimal_gland1.11735857
109MP0001963_abnormal_hearing_physiology1.10980049
110MP0003633_abnormal_nervous_system1.10783021
111MP0005253_abnormal_eye_physiology1.10485922
112MP0005646_abnormal_pituitary_gland1.08761783
113MP0002752_abnormal_somatic_nervous1.07666879
114MP0000465_gastrointestinal_hemorrhage1.06839399
115MP0004381_abnormal_hair_follicle1.06181907
116MP0001851_eye_inflammation1.05474196
117MP0009764_decreased_sensitivity_to1.03210599
118MP0003631_nervous_system_phenotype1.03192230
119MP0002933_joint_inflammation1.02932016
120MP0010386_abnormal_urinary_bladder1.01116380
121MP0002152_abnormal_brain_morphology1.00503631
122MP0003646_muscle_fatigue0.99540559
123MP0001533_abnormal_skeleton_physiology0.98463477
124MP0004043_abnormal_pH_regulation0.98274567
125MP0002928_abnormal_bile_duct0.97389056
126MP0000013_abnormal_adipose_tissue0.97281797
127MP0001299_abnormal_eye_distance/0.94729657
128MP0003632_abnormal_nervous_system0.93831947
129MP0000631_abnormal_neuroendocrine_gland0.92893505
130MP0005171_absent_coat_pigmentation0.92391280
131MP0003183_abnormal_peptide_metabolism0.91652342
132MP0003950_abnormal_plasma_membrane0.90216762
133MP0001986_abnormal_taste_sensitivity0.89913647
134MP0000751_myopathy0.89275396
135MP0000747_muscle_weakness0.88424329
136MP0003045_fibrosis0.88366455
137MP0004085_abnormal_heartbeat0.87034166
138MP0000462_abnormal_digestive_system0.86835193
139MP0002653_abnormal_ependyma_morphology0.85196408
140MP0010678_abnormal_skin_adnexa0.85161189
141MP0001346_abnormal_lacrimal_gland0.84625848
142MP0002998_abnormal_bone_remodeling0.82592339
143MP0002069_abnormal_eating/drinking_beha0.82329326
144MP0001663_abnormal_digestive_system0.81705934
145MP0003879_abnormal_hair_cell0.81673596
146MP0005535_abnormal_body_temperature0.80823400
147MP0004883_abnormal_blood_vessel0.80606315
148MP0000026_abnormal_inner_ear0.79270829
149MP0008469_abnormal_protein_level0.78655019
150MP0004484_altered_response_of0.78300712
151MP0002090_abnormal_vision0.76088943
152MP0002234_abnormal_pharynx_morphology0.75625446
153MP0003828_pulmonary_edema0.75536583
154MP0009278_abnormal_bone_marrow0.74548043
155MP0000371_diluted_coat_color0.74257781
156MP0009115_abnormal_fat_cell0.73423543
157MP0005195_abnormal_posterior_eye0.72925597
158MP0003938_abnormal_ear_development0.72268301
159MP0000383_abnormal_hair_follicle0.71512684
160MP0001765_abnormal_ion_homeostasis0.71488972
161MP0002693_abnormal_pancreas_physiology0.71007254
162MP0004858_abnormal_nervous_system0.70964792
163MP0004185_abnormal_adipocyte_glucose0.70607234
164MP0003122_maternal_imprinting0.69236905
165MP0002009_preneoplasia0.69097587
166MP0001177_atelectasis0.68707707
167MP0000427_abnormal_hair_cycle0.66217909
168MP0004808_abnormal_hematopoietic_stem0.63343123
169MP0002876_abnormal_thyroid_physiology0.62950731
170MP0002095_abnormal_skin_pigmentation0.60579593
171MP0004264_abnormal_extraembryonic_tissu0.55127900
172MP0002136_abnormal_kidney_physiology0.53909549
173MP0000858_altered_metastatic_potential0.50974195
174MP0003656_abnormal_erythrocyte_physiolo0.50943966
175MP0002277_abnormal_respiratory_mucosa0.50053785
176MP0002132_abnormal_respiratory_system0.49845061
177MP0000249_abnormal_blood_vessel0.48412928
178MP0009763_increased_sensitivity_to0.47591497
179MP0005397_hematopoietic_system_phenotyp0.46851554
180MP0001545_abnormal_hematopoietic_system0.46851554
181MP0000470_abnormal_stomach_morphology0.45290544

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.17860956
2Abnormality of T cell number (HP:0011839)4.80370624
3Focal motor seizures (HP:0011153)4.68868986
4Neurofibrillary tangles (HP:0002185)4.54690749
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.37970390
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.37970390
7Eczematoid dermatitis (HP:0000976)4.22331460
8Supranuclear gaze palsy (HP:0000605)4.13926695
9Myokymia (HP:0002411)4.08115399
10Cerebral inclusion bodies (HP:0100314)4.05248487
11Recurrent fungal infections (HP:0002841)4.00129886
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.92636852
13Focal seizures (HP:0007359)3.85051861
14Elevated erythrocyte sedimentation rate (HP:0003565)3.72842289
15Abnormality of the corticospinal tract (HP:0002492)3.71325347
16Recurrent cutaneous fungal infections (HP:0011370)3.70897080
17Chronic mucocutaneous candidiasis (HP:0002728)3.70897080
18Retrobulbar optic neuritis (HP:0100654)3.65239444
19Optic neuritis (HP:0100653)3.65239444
20Myositis (HP:0100614)3.62157219
21Visual hallucinations (HP:0002367)3.61555216
22Abnormality of T cells (HP:0002843)3.52088911
23Severe combined immunodeficiency (HP:0004430)3.44208990
24Panhypogammaglobulinemia (HP:0003139)3.42756591
25Progressive cerebellar ataxia (HP:0002073)3.41901533
26Atonic seizures (HP:0010819)3.37781687
27Recurrent bacterial skin infections (HP:0005406)3.36613842
28Gastrointestinal infarctions (HP:0005244)3.36288536
29Stomatitis (HP:0010280)3.27453428
30Peripheral hypomyelination (HP:0007182)3.25939782
31Orchitis (HP:0100796)3.24669840
32Insidious onset (HP:0003587)3.23996360
33Termporal pattern (HP:0011008)3.23996360
34Dysmetria (HP:0001310)3.21605303
35Sensory axonal neuropathy (HP:0003390)3.20873123
36Pustule (HP:0200039)3.16710851
37Recurrent bronchitis (HP:0002837)3.15479073
38Vasculitis (HP:0002633)3.14131470
39Abnormality of the fingertips (HP:0001211)3.12865628
40Action tremor (HP:0002345)3.11845262
41Abnormality of eosinophils (HP:0001879)3.11713494
42Broad-based gait (HP:0002136)3.05193483
43Meningitis (HP:0001287)3.03577997
44Recurrent viral infections (HP:0004429)3.01676144
45Lymphopenia (HP:0001888)3.01472271
46Spontaneous hematomas (HP:0007420)3.01024835
47Absence seizures (HP:0002121)3.00170167
48Leukocytosis (HP:0001974)2.97525147
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.96780608
50Spastic gait (HP:0002064)2.93533325
51Encephalitis (HP:0002383)2.93101978
52IgG deficiency (HP:0004315)2.88738671
53Dialeptic seizures (HP:0011146)2.83986566
54Recurrent abscess formation (HP:0002722)2.83215939
55Epileptic encephalopathy (HP:0200134)2.81120215
56Keratoconjunctivitis (HP:0001096)2.79278981
57Absent/shortened dynein arms (HP:0200106)2.78169466
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.78169466
59Intention tremor (HP:0002080)2.76199081
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.73259287
61Thyroiditis (HP:0100646)2.71938320
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70972164
63Agammaglobulinemia (HP:0004432)2.70422271
64Eosinophilia (HP:0001880)2.68508370
65Recurrent skin infections (HP:0001581)2.67067062
66Abnormality of macrophages (HP:0004311)2.61696085
67Abnormal ciliary motility (HP:0012262)2.61119348
68Stomach cancer (HP:0012126)2.61094317
69Gaze-evoked nystagmus (HP:0000640)2.58715439
70Urinary bladder sphincter dysfunction (HP:0002839)2.55554820
71Inflammation of the large intestine (HP:0002037)2.54343720
72Mediastinal lymphadenopathy (HP:0100721)2.54212056
73Onion bulb formation (HP:0003383)2.52631609
74Granulocytopenia (HP:0001913)2.51496740
75Keratoconjunctivitis sicca (HP:0001097)2.51118833
76Drooling (HP:0002307)2.49873682
77Excessive salivation (HP:0003781)2.49873682
78Combined immunodeficiency (HP:0005387)2.49726027
79Truncal ataxia (HP:0002078)2.49680443
80Chest pain (HP:0100749)2.49658100
81Hemoptysis (HP:0002105)2.49575452
82Chronic diarrhea (HP:0002028)2.49436483
83Pulmonary infiltrates (HP:0002113)2.45544713
84Chronic hepatic failure (HP:0100626)2.43889525
85Dysdiadochokinesis (HP:0002075)2.43720354
86Ankle clonus (HP:0011448)2.43282510
87Abnormal respiratory motile cilium physiology (HP:0012261)2.42603143
88Increased circulating renin level (HP:0000848)2.41009092
89Parakeratosis (HP:0001036)2.39792964
90Gastrointestinal inflammation (HP:0004386)2.39609210
91Febrile seizures (HP:0002373)2.38865713
92Anxiety (HP:0000739)2.36229140
93Increased IgE level (HP:0003212)2.35972831
94Generalized tonic-clonic seizures (HP:0002069)2.32164806
95Autoimmune hemolytic anemia (HP:0001890)2.32048572
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30329277
97Hemiplegia (HP:0002301)2.30263265
98Widely spaced teeth (HP:0000687)2.30043487
99Hypoplasia of the thymus (HP:0000778)2.26915328
100Abnormality of T cell physiology (HP:0011840)2.26728477
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26318682
102Bowel incontinence (HP:0002607)2.25569893
103IgM deficiency (HP:0002850)2.25376278
104Alacrima (HP:0000522)2.24348680
105Akinesia (HP:0002304)2.21354657
106Gastrointestinal stroma tumor (HP:0100723)2.20371285
107Muscle hypertrophy of the lower extremities (HP:0008968)2.20198612
108Lower limb muscle weakness (HP:0007340)2.18528548
109Hyperventilation (HP:0002883)2.17868391
110Autoimmune thrombocytopenia (HP:0001973)2.17225713
111Basal cell carcinoma (HP:0002671)2.15596790
112Papilledema (HP:0001085)2.15107114
113Urinary urgency (HP:0000012)2.14620847
114Impaired vibration sensation in the lower limbs (HP:0002166)2.13642506
115Verrucae (HP:0200043)2.13492410
116Papilloma (HP:0012740)2.13492410
117Gingivitis (HP:0000230)2.09897653
118Depression (HP:0000716)2.09798116
119Neuronal loss in central nervous system (HP:0002529)2.08929747
120Recurrent sinusitis (HP:0011108)2.08904908
121Scanning speech (HP:0002168)2.07725564
122Hypoplastic nipples (HP:0002557)2.06398756
123Retinal dysplasia (HP:0007973)2.06272455
124Abnormality of calcium-phosphate metabolism (HP:0100530)2.05537988
125Chin dimple (HP:0010751)2.05197446
126Abnormal respiratory motile cilium morphology (HP:0005938)2.04314533
127Abnormal respiratory epithelium morphology (HP:0012253)2.04314533
128Colitis (HP:0002583)2.03882403
129Amblyopia (HP:0000646)2.03432190
130Rapidly progressive (HP:0003678)2.02938358
131Abnormal large intestine physiology (HP:0012700)2.02376195
132Abnormality of B cell number (HP:0010975)2.01799313
133Prolonged bleeding time (HP:0003010)2.00166234
134Recurrent gram-negative bacterial infections (HP:0005420)2.00034163
135Hyporeflexia of lower limbs (HP:0002600)1.95632246
136Postural tremor (HP:0002174)1.95097740
137Abnormality of binocular vision (HP:0011514)1.94879443
138Diplopia (HP:0000651)1.94879443
139Truncal obesity (HP:0001956)1.94554224
140Decreased lacrimation (HP:0000633)1.93438917
141Agitation (HP:0000713)1.92195016
142Hyperthyroidism (HP:0000836)1.91914823
143Bronchitis (HP:0012387)1.91785864
144IgA deficiency (HP:0002720)1.91503881
145Clumsiness (HP:0002312)1.91403839
146Postural instability (HP:0002172)1.90956967
147Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90671494
148Slow saccadic eye movements (HP:0000514)1.90435852
149Gingival bleeding (HP:0000225)1.88324963
150Abnormality of salivation (HP:0100755)1.87299715
151Psychosis (HP:0000709)1.85963047
152Genetic anticipation (HP:0003743)1.85306441
153Pheochromocytoma (HP:0002666)1.84908905
154Epileptiform EEG discharges (HP:0011182)1.84370825
155Pulmonary embolism (HP:0002204)1.84052062
156Decreased circulating renin level (HP:0003351)1.83090667
157Obstructive lung disease (HP:0006536)1.82431385
158Chronic obstructive pulmonary disease (HP:0006510)1.82431385
159Central scotoma (HP:0000603)1.82160971
160EEG with generalized epileptiform discharges (HP:0011198)1.81894005
161Thickened helices (HP:0000391)1.81800243
162Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81770722
163Hemiparesis (HP:0001269)1.81249652
164Sepsis (HP:0100806)1.80441408
165Limb dystonia (HP:0002451)1.80081473
166Hypochromic anemia (HP:0001931)1.80034690
167Protruding tongue (HP:0010808)1.79999236
168Arterial thrombosis (HP:0004420)1.79359353
169Insomnia (HP:0100785)1.79120769
170Lymphoma (HP:0002665)1.78251952
171Exotropia (HP:0000577)1.78100716
172Anosmia (HP:0000458)1.78039317
173Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77608995
174Hematochezia (HP:0002573)1.75622076
175Neoplasm of the tracheobronchial system (HP:0100552)1.73786398
176Hypsarrhythmia (HP:0002521)1.73312570
177Neonatal hypoglycemia (HP:0001998)1.73308235
178Abnormal eating behavior (HP:0100738)1.73110552
179Hyperkalemia (HP:0002153)1.72398713
180Mutism (HP:0002300)1.72305390
181Prominent nose (HP:0000448)1.71268780
182Rhinitis (HP:0012384)1.71086527
183Blue irides (HP:0000635)1.70451453
184Anorexia (HP:0002039)1.70391232
185Decreased motor nerve conduction velocity (HP:0003431)1.69731684
186Recurrent pneumonia (HP:0006532)1.69581977
187Absent speech (HP:0001344)1.68392458
188Epistaxis (HP:0000421)1.68335355
189Congenital stationary night blindness (HP:0007642)1.68010478
190Metabolic alkalosis (HP:0200114)1.67816489
191Keratitis (HP:0000491)1.67447212
192Ulnar claw (HP:0001178)1.66623436
193Abnormality of the pleura (HP:0002103)1.66527536
194Joint swelling (HP:0001386)1.66351863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.88870436
2STK393.47516319
3NTRK33.34607885
4EPHA42.93809199
5PNCK2.93335509
6TXK2.85151707
7BLK2.73053020
8FRK2.63123583
9MAP3K92.32221914
10MAP3K42.23535954
11MARK12.22429143
12OXSR12.07169828
13CDK121.96594140
14WNK41.93091750
15TYK21.90586476
16RIPK41.89805456
17CAMKK21.89719230
18BTK1.78434311
19NTRK11.77764936
20WNK11.75898959
21GRK61.74054556
22CAMK1G1.70974916
23ITK1.70863662
24CASK1.69958148
25JAK11.68694215
26PKN11.67271288
27FGR1.64870235
28SYK1.62492904
29MAP3K21.62329851
30CSK1.57958800
31SGK21.56673731
32INSRR1.56491106
33TNIK1.55764780
34IKBKE1.55065399
35FES1.53949524
36NTRK21.51790484
37UHMK11.51729212
38TYRO31.51256489
39NLK1.47696766
40MAP3K101.43428221
41ZAP701.41728084
42EPHB11.40756879
43MAP3K141.39834767
44TNK21.38942430
45IRAK21.35998950
46KSR21.34149536
47LCK1.31179357
48PRPF4B1.29160435
49CDK51.28674735
50JAK31.26671926
51MAP2K71.25074769
52PRKD31.24996842
53MAPK151.21804662
54PAK61.21564835
55HCK1.20607311
56CSF1R1.19940457
57IRAK41.19484836
58LYN1.16518998
59MARK31.15908741
60FGFR31.14790980
61SIK21.13484997
62TEC1.12526108
63MINK11.11850807
64MAP3K131.11040509
65MAPK131.09535777
66SGK31.08499435
67PRKD21.08378313
68DMPK1.08104670
69SGK2231.07881394
70SGK4941.07881394
71GRK51.05600332
72PAK31.05508182
73MARK21.05396413
74GRK71.05314486
75BRD41.05219546
76ICK1.05003166
77MAP2K41.04899880
78PHKG21.03673010
79PHKG11.03673010
80PASK1.01143268
81PRKCH1.00041342
82FGFR20.99444896
83MAP4K20.98052837
84CAMK2B0.96908866
85STK110.96161332
86CAMK2A0.95952906
87MAPKAPK50.95819400
88CSNK1G20.94698056
89CDK190.94306413
90CSNK1A1L0.89512886
91STK380.88205363
92AKT30.87925064
93ROCK20.87350559
94EPHA30.86172621
95KIT0.86124590
96PTK2B0.85660639
97PRKCQ0.84984477
98SIK30.82958200
99IRAK10.82831908
100CSNK1G30.82555559
101JAK20.81422156
102PIM10.81287898
103BCR0.80767859
104NEK60.80133044
105CAMK40.78285278
106FGFR40.78235562
107DYRK1B0.77889480
108RET0.75973564
109TAOK10.75714358
110MET0.75614925
111CAMK2D0.73597340
112CLK10.73462858
113FYN0.73441087
114HIPK20.72915942
115CDC42BPA0.72836594
116PIK3CG0.70546098
117MAP3K10.70242544
118MELK0.69310187
119IKBKB0.67953331
120CSNK1G10.66602283
121ACVR1B0.66401815
122SGK10.66261497
123ADRBK20.66119051
124PRKCE0.65601535
125MAPK70.65029504
126PDGFRB0.64312434
127CAMK10.63894678
128DYRK1A0.63866139
129BMPR20.63658582
130YES10.63467260
131DAPK20.63121040
132CDK40.61116342
133ERN10.59782674
134PDPK10.58827779
135PRKD10.56360422
136NME10.55712687
137CDK30.55498817
138FER0.53795592
139MAP3K70.53316916
140CHUK0.53090576
141PLK20.52696181
142CAMK1D0.50264052
143MAPK120.48713767
144PDK10.48659491
145TAOK30.47797766
146TBK10.47180460
147PRKCG0.45629236
148PRKG10.45077270
149CDK140.44782135
150PRKAA20.44678900
151MAPK110.44046241
152CDK60.43444651
153KSR10.42828498
154CAMKK10.41546854
155MAPK100.41458873
156PRKACA0.41305093
157BMPR1B0.39904909
158MAP2K30.39667598
159CDK150.39526629
160PRKCZ0.38996851
161RPS6KA60.37455338

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.30246207
2Nicotine addiction_Homo sapiens_hsa050332.49585871
3Graft-versus-host disease_Homo sapiens_hsa053322.38436456
4Glutamatergic synapse_Homo sapiens_hsa047242.27222041
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.25001882
6Allograft rejection_Homo sapiens_hsa053302.24566134
7Autoimmune thyroid disease_Homo sapiens_hsa053202.23442496
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20469975
9GABAergic synapse_Homo sapiens_hsa047272.10255378
10Morphine addiction_Homo sapiens_hsa050322.08847748
11Circadian entrainment_Homo sapiens_hsa047132.06905752
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.05155757
13Long-term potentiation_Homo sapiens_hsa047202.01136688
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95891477
15Amphetamine addiction_Homo sapiens_hsa050311.92563312
16Osteoclast differentiation_Homo sapiens_hsa043801.89512532
17Serotonergic synapse_Homo sapiens_hsa047261.85910945
18Phototransduction_Homo sapiens_hsa047441.83483888
19Dopaminergic synapse_Homo sapiens_hsa047281.82465525
20Renin secretion_Homo sapiens_hsa049241.80587283
21Salivary secretion_Homo sapiens_hsa049701.79908269
22Synaptic vesicle cycle_Homo sapiens_hsa047211.77832601
23Insulin secretion_Homo sapiens_hsa049111.76275814
24Long-term depression_Homo sapiens_hsa047301.74099099
25Taste transduction_Homo sapiens_hsa047421.73022090
26Axon guidance_Homo sapiens_hsa043601.72728127
27Cholinergic synapse_Homo sapiens_hsa047251.69588311
28Olfactory transduction_Homo sapiens_hsa047401.67671462
29Gastric acid secretion_Homo sapiens_hsa049711.67389154
30Leishmaniasis_Homo sapiens_hsa051401.66917985
31Measles_Homo sapiens_hsa051621.66638129
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.63516316
33Dorso-ventral axis formation_Homo sapiens_hsa043201.60886388
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56057385
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.54470685
36Cocaine addiction_Homo sapiens_hsa050301.53819306
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53362785
38Staphylococcus aureus infection_Homo sapiens_hsa051501.53037208
39Hematopoietic cell lineage_Homo sapiens_hsa046401.49337252
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46584028
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44102577
42Type II diabetes mellitus_Homo sapiens_hsa049301.42698849
43Oxytocin signaling pathway_Homo sapiens_hsa049211.42596274
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37401140
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33646716
46Asthma_Homo sapiens_hsa053101.33564379
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31767606
48Antigen processing and presentation_Homo sapiens_hsa046121.29590895
49GnRH signaling pathway_Homo sapiens_hsa049121.29568268
50Collecting duct acid secretion_Homo sapiens_hsa049661.28295006
51Calcium signaling pathway_Homo sapiens_hsa040201.27066834
52Viral myocarditis_Homo sapiens_hsa054161.26897533
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25145423
54Tuberculosis_Homo sapiens_hsa051521.24808098
55FoxO signaling pathway_Homo sapiens_hsa040681.24280321
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23380092
57Acute myeloid leukemia_Homo sapiens_hsa052211.22680795
58Pancreatic secretion_Homo sapiens_hsa049721.21531070
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21336461
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18390924
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17655643
62Ether lipid metabolism_Homo sapiens_hsa005651.17196527
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.15165789
64cAMP signaling pathway_Homo sapiens_hsa040241.14084534
65Herpes simplex infection_Homo sapiens_hsa051681.13121898
66Toxoplasmosis_Homo sapiens_hsa051451.13081822
67Estrogen signaling pathway_Homo sapiens_hsa049151.09995307
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09518571
69Influenza A_Homo sapiens_hsa051641.08741053
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08612445
71Prolactin signaling pathway_Homo sapiens_hsa049171.08106462
72Choline metabolism in cancer_Homo sapiens_hsa052311.04545434
73Hepatitis B_Homo sapiens_hsa051611.04312575
74Regulation of autophagy_Homo sapiens_hsa041401.03569999
75Cardiac muscle contraction_Homo sapiens_hsa042601.03343818
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02112065
77ErbB signaling pathway_Homo sapiens_hsa040121.01164360
78Gap junction_Homo sapiens_hsa045400.98924845
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.96957910
80Alzheimers disease_Homo sapiens_hsa050100.94599509
81TNF signaling pathway_Homo sapiens_hsa046680.93186335
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91691663
83Vibrio cholerae infection_Homo sapiens_hsa051100.91634638
84Melanogenesis_Homo sapiens_hsa049160.91455328
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.91298095
86Renal cell carcinoma_Homo sapiens_hsa052110.90413448
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89196398
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.85507902
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.84402027
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83992082
91MAPK signaling pathway_Homo sapiens_hsa040100.81786571
92Colorectal cancer_Homo sapiens_hsa052100.81390816
93Glioma_Homo sapiens_hsa052140.81154333
94Oxidative phosphorylation_Homo sapiens_hsa001900.81070113
95Endometrial cancer_Homo sapiens_hsa052130.81015993
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80743813
97Ras signaling pathway_Homo sapiens_hsa040140.80685809
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79951794
99Hepatitis C_Homo sapiens_hsa051600.79661269
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77862659
101Notch signaling pathway_Homo sapiens_hsa043300.75927038
102Inositol phosphate metabolism_Homo sapiens_hsa005620.75490922
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74261997
104Malaria_Homo sapiens_hsa051440.73642262
105Chronic myeloid leukemia_Homo sapiens_hsa052200.73596785
106Thyroid hormone synthesis_Homo sapiens_hsa049180.70723085
107Prostate cancer_Homo sapiens_hsa052150.70234245
108Pancreatic cancer_Homo sapiens_hsa052120.69566839
109Dilated cardiomyopathy_Homo sapiens_hsa054140.69142112
110VEGF signaling pathway_Homo sapiens_hsa043700.68769524
111ABC transporters_Homo sapiens_hsa020100.65562858
112mTOR signaling pathway_Homo sapiens_hsa041500.63164466
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.62872011
114Sphingolipid metabolism_Homo sapiens_hsa006000.62650192
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61928361
116Apoptosis_Homo sapiens_hsa042100.61835599
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59186117
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58537431
119T cell receptor signaling pathway_Homo sapiens_hsa046600.57898015
120Fatty acid elongation_Homo sapiens_hsa000620.57168338
121Viral carcinogenesis_Homo sapiens_hsa052030.57006284
122Wnt signaling pathway_Homo sapiens_hsa043100.56983958
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56890823
124Ovarian steroidogenesis_Homo sapiens_hsa049130.54993761
125Endocytosis_Homo sapiens_hsa041440.54993396
126Caffeine metabolism_Homo sapiens_hsa002320.54784007
127Insulin resistance_Homo sapiens_hsa049310.54726607
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53864763
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53170469
130Epstein-Barr virus infection_Homo sapiens_hsa051690.51960607
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51131722
132Lysine degradation_Homo sapiens_hsa003100.50843501
133HTLV-I infection_Homo sapiens_hsa051660.50282113
134Sulfur metabolism_Homo sapiens_hsa009200.49867829
135Chemokine signaling pathway_Homo sapiens_hsa040620.49740937
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49394788
137Phagosome_Homo sapiens_hsa041450.49056871
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.48663082
139Prion diseases_Homo sapiens_hsa050200.48641608
140Circadian rhythm_Homo sapiens_hsa047100.48507085
141Tight junction_Homo sapiens_hsa045300.46003171
142Rheumatoid arthritis_Homo sapiens_hsa053230.44907828
143Steroid biosynthesis_Homo sapiens_hsa001000.44191979
144Rap1 signaling pathway_Homo sapiens_hsa040150.43895828
145B cell receptor signaling pathway_Homo sapiens_hsa046620.43712839
146African trypanosomiasis_Homo sapiens_hsa051430.43391408
147Glucagon signaling pathway_Homo sapiens_hsa049220.43339907
148Type I diabetes mellitus_Homo sapiens_hsa049400.41143346
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40225617
150Linoleic acid metabolism_Homo sapiens_hsa005910.40042498
151Platelet activation_Homo sapiens_hsa046110.39468037
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39438696
153Parkinsons disease_Homo sapiens_hsa050120.38581494
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38319095
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37896537
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37388625
157Alcoholism_Homo sapiens_hsa050340.36999466
158Mineral absorption_Homo sapiens_hsa049780.34998274
159Non-small cell lung cancer_Homo sapiens_hsa052230.34718244

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