SYPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.08524758
2ribosome assembly (GO:0042255)4.68607046
3negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.85869250
4toxin transport (GO:1901998)3.80252166
5peptidyl-proline hydroxylation (GO:0019511)3.73700017
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71411581
7ribosomal large subunit biogenesis (GO:0042273)3.66092611
8regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60955460
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.59319628
10protein hydroxylation (GO:0018126)3.57759159
11AMP metabolic process (GO:0046033)3.48652821
12formation of translation preinitiation complex (GO:0001731)3.46080719
134-hydroxyproline metabolic process (GO:0019471)3.45970414
14response to nitric oxide (GO:0071731)3.41924337
15cullin deneddylation (GO:0010388)3.40565330
16carnitine transmembrane transport (GO:1902603)3.40257532
17IMP biosynthetic process (GO:0006188)3.37539106
18IMP metabolic process (GO:0046040)3.36841506
19branched-chain amino acid catabolic process (GO:0009083)3.35935929
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35482505
21negative regulation of ligase activity (GO:0051352)3.35482505
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30134425
23labyrinthine layer development (GO:0060711)3.27869149
24carnitine transport (GO:0015879)3.25782646
25amino-acid betaine transport (GO:0015838)3.25782646
26response to nitrosative stress (GO:0051409)3.25282714
27regulation of cellular amino acid metabolic process (GO:0006521)3.24802103
28xenobiotic catabolic process (GO:0042178)3.23461170
29synapsis (GO:0007129)3.11139035
30negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.08667250
31RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05785413
32negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.05725769
33positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05164182
34protein deneddylation (GO:0000338)3.05110798
35glycerol ether metabolic process (GO:0006662)3.04122670
36ether lipid metabolic process (GO:0046485)3.03427863
37purine nucleotide salvage (GO:0032261)3.03042017
38CENP-A containing nucleosome assembly (GO:0034080)3.02678864
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98412169
40positive regulation of ligase activity (GO:0051351)2.93671267
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91216250
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86026529
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86026529
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86026529
45L-methionine salvage (GO:0071267)2.85956176
46L-methionine biosynthetic process (GO:0071265)2.85956176
47amino acid salvage (GO:0043102)2.85956176
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85699440
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85699440
50rRNA modification (GO:0000154)2.83871832
51mitotic G2 DNA damage checkpoint (GO:0007095)2.82447053
52tricarboxylic acid cycle (GO:0006099)2.80658777
53telomere maintenance via semi-conservative replication (GO:0032201)2.78668870
54regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.77464833
55quaternary ammonium group transport (GO:0015697)2.75002576
56signal transduction involved in DNA damage checkpoint (GO:0072422)2.74422797
57signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74422797
58mitotic G2/M transition checkpoint (GO:0044818)2.72164297
59protein maturation by protein folding (GO:0022417)2.70560623
60regulation of ubiquitin-protein transferase activity (GO:0051438)2.70438295
61chromatin remodeling at centromere (GO:0031055)2.69904845
62ether metabolic process (GO:0018904)2.68983619
63purine nucleobase biosynthetic process (GO:0009113)2.67677770
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66953499
65desmosome organization (GO:0002934)2.65322604
66regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.65073293
67response to X-ray (GO:0010165)2.64866576
68rRNA methylation (GO:0031167)2.64538620
69histone exchange (GO:0043486)2.62521153
70signal transduction involved in cell cycle checkpoint (GO:0072395)2.62511241
71glutathione derivative biosynthetic process (GO:1901687)2.62412167
72glutathione derivative metabolic process (GO:1901685)2.62412167
73regulation of ligase activity (GO:0051340)2.62286651
74branched-chain amino acid metabolic process (GO:0009081)2.57925548
75ribosomal small subunit assembly (GO:0000028)2.56294140
76establishment of integrated proviral latency (GO:0075713)2.54332444
77telomere maintenance via recombination (GO:0000722)2.53049324
78nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52153710
79maturation of 5.8S rRNA (GO:0000460)2.50708649
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50493523
81negative regulation of signal transduction by p53 class mediator (GO:1901797)2.49380004
82cell cycle G1/S phase transition (GO:0044843)2.49326041
83G1/S transition of mitotic cell cycle (GO:0000082)2.49326041
84piRNA metabolic process (GO:0034587)2.46953752
85oxidative phosphorylation (GO:0006119)2.46047905
86hepatocyte differentiation (GO:0070365)2.42472292
87nucleobase biosynthetic process (GO:0046112)2.38778453
88peptidyl-histidine modification (GO:0018202)2.38686822
89mitotic metaphase plate congression (GO:0007080)2.37524311
90mitotic spindle checkpoint (GO:0071174)2.35690741
91mitotic recombination (GO:0006312)2.35129551
92negative regulation of protein ubiquitination (GO:0031397)2.33594123
93somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.33111446
94somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.33111446
95isotype switching (GO:0045190)2.33111446
96regulation of cellular amine metabolic process (GO:0033238)2.32583079
97dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.32173106
98purine-containing compound salvage (GO:0043101)2.31552498
99organic cation transport (GO:0015695)2.30801231
100nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.30785764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84029719
2E2F7_22180533_ChIP-Seq_HELA_Human3.55562569
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18556514
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.16508159
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94926595
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.84488360
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82666249
8ELK1_19687146_ChIP-ChIP_HELA_Human2.51807796
9AR_21909140_ChIP-Seq_LNCAP_Human2.39563867
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.37182157
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29911496
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16569722
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06777788
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00529995
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99403780
16PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.96330543
17FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93918297
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90188651
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88604816
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88198360
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.88062159
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85989697
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83638083
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79931322
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.75913182
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74156968
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73400865
28VDR_23849224_ChIP-Seq_CD4+_Human1.72889903
29DCP1A_22483619_ChIP-Seq_HELA_Human1.68848653
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65044118
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64598566
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60241973
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60019851
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.58994284
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.58770578
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57081048
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.52050769
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50811404
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49491486
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48988107
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.48683955
42FUS_26573619_Chip-Seq_HEK293_Human1.48667139
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.48121302
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44109891
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43678046
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40214280
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39895098
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34473055
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31864507
50VDR_22108803_ChIP-Seq_LS180_Human1.30060152
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28805770
52* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27738717
53EWS_26573619_Chip-Seq_HEK293_Human1.22998790
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22925111
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22677588
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22677588
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21762781
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.21303424
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.19955415
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.19511459
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16788381
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14958087
63BRD4_25478319_ChIP-Seq_HGPS_Human1.14830135
64GATA1_22025678_ChIP-Seq_K562_Human1.11914133
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09665198
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09376697
67* GATA3_24758297_ChIP-Seq_MCF-7_Human1.09129919
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08905922
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08162352
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07537318
71* TTF2_22483619_ChIP-Seq_HELA_Human1.04782430
72CLOCK_20551151_ChIP-Seq_293T_Human1.04050472
73* SOX2_20726797_ChIP-Seq_SW620_Human1.03751294
74CDX2_22108803_ChIP-Seq_LS180_Human1.02565165
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02453137
76* ELF5_23300383_ChIP-Seq_T47D_Human1.02365412
77CJUN_26792858_Chip-Seq_BT549_Human1.02000291
78GABP_19822575_ChIP-Seq_HepG2_Human1.00866429
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98343481
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98337997
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97336510
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.97336510
83AR_20517297_ChIP-Seq_VCAP_Human0.96596310
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95721919
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94684253
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.93899182
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93851433
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.93422153
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91691747
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91556444
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91554845
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91056319
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90019350
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88257085
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87479742
96GATA4_25053715_ChIP-Seq_YYC3_Human0.86829641
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86643751
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86461340
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.86113703
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.85907082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.68641896
2MP0003941_abnormal_skin_development2.83316251
3MP0009697_abnormal_copulation2.63387505
4MP0010678_abnormal_skin_adnexa2.42311708
5MP0000383_abnormal_hair_follicle2.32359103
6MP0008058_abnormal_DNA_repair2.26764280
7MP0002396_abnormal_hematopoietic_system2.20557032
8MP0004957_abnormal_blastocyst_morpholog2.18838467
9MP0006054_spinal_hemorrhage2.15840886
10MP0000013_abnormal_adipose_tissue2.12551570
11MP0003786_premature_aging2.05008885
12MP0010234_abnormal_vibrissa_follicle2.04976671
13MP0010094_abnormal_chromosome_stability2.02109755
14MP0002132_abnormal_respiratory_system2.00076506
15MP0002796_impaired_skin_barrier1.99629720
16MP0000372_irregular_coat_pigmentation1.89951064
17MP0010352_gastrointestinal_tract_polyps1.86954880
18MP0008007_abnormal_cellular_replicative1.78802463
19MP0003718_maternal_effect1.77017313
20MP0006036_abnormal_mitochondrial_physio1.75600929
21MP0004484_altered_response_of1.75598230
22MP0003186_abnormal_redox_activity1.72899755
23MP0003950_abnormal_plasma_membrane1.70564558
24MP0002138_abnormal_hepatobiliary_system1.69637489
25MP0001661_extended_life_span1.59865904
26MP0005275_abnormal_skin_tensile1.59115314
27MP0000762_abnormal_tongue_morphology1.58462996
28MP0005084_abnormal_gallbladder_morpholo1.58187253
29MP0004264_abnormal_extraembryonic_tissu1.56738695
30MP0005330_cardiomyopathy1.56150340
31MP0002060_abnormal_skin_morphology1.55087262
32MP0004782_abnormal_surfactant_physiolog1.38826635
33MP0004233_abnormal_muscle_weight1.36251654
34MP0010368_abnormal_lymphatic_system1.36245699
35MP0000749_muscle_degeneration1.32450845
36MP0009780_abnormal_chondrocyte_physiolo1.30941090
37MP0004272_abnormal_basement_membrane1.30305414
38MP0003077_abnormal_cell_cycle1.25743520
39MP0003252_abnormal_bile_duct1.23683307
40MP0005165_increased_susceptibility_to1.23382857
41MP0000678_abnormal_parathyroid_gland1.22872696
42MP0008932_abnormal_embryonic_tissue1.22448816
43MP0003111_abnormal_nucleus_morphology1.21728174
44MP0001216_abnormal_epidermal_layer1.19231538
45MP0005332_abnormal_amino_acid1.18610705
46MP0003191_abnormal_cellular_cholesterol1.16316722
47MP0008875_abnormal_xenobiotic_pharmacok1.13853584
48MP0004215_abnormal_myocardial_fiber1.12132081
49MP0003943_abnormal_hepatobiliary_system1.11782811
50MP0005501_abnormal_skin_physiology1.11272151
51MP0008877_abnormal_DNA_methylation1.11215382
52MP0005075_abnormal_melanosome_morpholog1.10849338
53MP0002006_tumorigenesis1.09154202
54MP0004808_abnormal_hematopoietic_stem1.09018184
55MP0004084_abnormal_cardiac_muscle1.07122397
56MP0003693_abnormal_embryo_hatching1.06346243
57MP0002139_abnormal_hepatobiliary_system1.06010505
58MP0000613_abnormal_salivary_gland1.05964722
59MP0002254_reproductive_system_inflammat1.04887072
60MP0005023_abnormal_wound_healing1.03955984
61MP0002160_abnormal_reproductive_system1.02295902
62MP0005408_hypopigmentation1.02003541
63MP0000579_abnormal_nail_morphology1.00935753
64MP0001243_abnormal_dermal_layer0.95908064
65MP0001764_abnormal_homeostasis0.94877621
66MP0002166_altered_tumor_susceptibility0.94841047
67MP0010771_integument_phenotype0.94466600
68MP0002877_abnormal_melanocyte_morpholog0.87800135
69MP0009643_abnormal_urine_homeostasis0.87631692
70MP0002837_dystrophic_cardiac_calcinosis0.87271894
71MP0002282_abnormal_trachea_morphology0.86625110
72MP0005083_abnormal_biliary_tract0.86209538
73MP0000627_abnormal_mammary_gland0.86104084
74MP0000465_gastrointestinal_hemorrhage0.84061531
75MP0005360_urolithiasis0.83391946
76MP0001881_abnormal_mammary_gland0.83211229
77MP0000350_abnormal_cell_proliferation0.83079126
78MP0005380_embryogenesis_phenotype0.82306765
79MP0001672_abnormal_embryogenesis/_devel0.82306765
80MP0000467_abnormal_esophagus_morphology0.81698942
81MP0000358_abnormal_cell_content/0.80011003
82MP0000598_abnormal_liver_morphology0.79800430
83MP0000377_abnormal_hair_follicle0.79247719
84MP0001666_abnormal_nutrient_absorption0.78981947
85MP0003984_embryonic_growth_retardation0.76833079
86MP0004036_abnormal_muscle_relaxation0.75445032
87MP0002088_abnormal_embryonic_growth/wei0.75292030
88MP0003315_abnormal_perineum_morphology0.74583794
89MP0005085_abnormal_gallbladder_physiolo0.74566723
90MP0002269_muscular_atrophy0.74475391
91MP0001191_abnormal_skin_condition0.73243131
92MP0002086_abnormal_extraembryonic_tissu0.72987569
93MP0005367_renal/urinary_system_phenotyp0.72499386
94MP0000516_abnormal_urinary_system0.72499386
95MP0005395_other_phenotype0.72403643
96MP0009931_abnormal_skin_appearance0.71718008
97MP0000681_abnormal_thyroid_gland0.70888254
98MP0008438_abnormal_cutaneous_collagen0.70689332
99MP0001697_abnormal_embryo_size0.68869366
100MP0003566_abnormal_cell_adhesion0.68224717

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.25137025
2Reduced antithrombin III activity (HP:0001976)4.30932248
3Type I transferrin isoform profile (HP:0003642)3.86362005
4Right ventricular cardiomyopathy (HP:0011663)3.74216912
5Palpitations (HP:0001962)3.49802869
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.39747366
7Abnormal protein N-linked glycosylation (HP:0012347)3.39747366
8Abnormal protein glycosylation (HP:0012346)3.39747366
9Abnormal glycosylation (HP:0012345)3.39747366
10Hypoglycemic seizures (HP:0002173)3.17153068
11Exercise-induced muscle cramps (HP:0003710)2.83642531
12Increased serum pyruvate (HP:0003542)2.76338403
13Alopecia of scalp (HP:0002293)2.69091274
14Sparse eyelashes (HP:0000653)2.60919758
15Abnormality of glycolysis (HP:0004366)2.54911041
16Central scotoma (HP:0000603)2.52531712
17Abnormality of the fetal cardiovascular system (HP:0010948)2.48850262
18Abnormal umbilical cord blood vessels (HP:0011403)2.48850262
19Single umbilical artery (HP:0001195)2.48850262
20Abnormality of fatty-acid metabolism (HP:0004359)2.45477792
21Plantar hyperkeratosis (HP:0007556)2.44056200
22Metaphyseal dysplasia (HP:0100255)2.43232352
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.40101147
24Abnormality of methionine metabolism (HP:0010901)2.38829831
25Symptomatic seizures (HP:0011145)2.35726464
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.35645955
27Posterior subcapsular cataract (HP:0007787)2.35165395
28Hyperalaninemia (HP:0003348)2.33982985
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33982985
30Abnormality of alanine metabolism (HP:0010916)2.33982985
31Rhabdomyolysis (HP:0003201)2.32063336
32Abnormality of the umbilical cord (HP:0010881)2.29841434
33Short middle phalanx of the 5th finger (HP:0004220)2.24792529
34Hyperammonemia (HP:0001987)2.21945514
35Conjunctival hamartoma (HP:0100780)2.21819806
36Myoglobinuria (HP:0002913)2.21581765
37Microglossia (HP:0000171)2.20857749
38Dyschromatopsia (HP:0007641)2.15846117
39Abnormalities of placenta or umbilical cord (HP:0001194)2.15360902
40B lymphocytopenia (HP:0010976)2.14777883
41Fragile nails (HP:0001808)2.14609031
42Abnormality of urine glucose concentration (HP:0011016)2.14332547
43Glycosuria (HP:0003076)2.14332547
44Palmoplantar hyperkeratosis (HP:0000972)2.11954791
45Hypoglycemic coma (HP:0001325)2.10225558
46Renal Fanconi syndrome (HP:0001994)2.07863398
47Tetraparesis (HP:0002273)2.07447333
48Amniotic constriction ring (HP:0009775)2.06811712
49Abnormality of placental membranes (HP:0011409)2.06811712
50Abnormality of serum amino acid levels (HP:0003112)2.06651259
51Palmar hyperkeratosis (HP:0010765)2.03777022
52Prolonged partial thromboplastin time (HP:0003645)2.03103408
53Intrahepatic cholestasis (HP:0001406)2.01806600
54Hyperinsulinemic hypoglycemia (HP:0000825)2.01581259
55Pancreatic islet-cell hyperplasia (HP:0004510)2.01258126
56Abnormality of B cell number (HP:0010975)2.01068670
57Loss of speech (HP:0002371)1.99477777
58Acute encephalopathy (HP:0006846)1.99081170
59Lethargy (HP:0001254)1.97165998
60Abnormal auditory evoked potentials (HP:0006958)1.95980256
61Hypoplasia of the uterus (HP:0000013)1.95326709
62Confusion (HP:0001289)1.95162041
63Popliteal pterygium (HP:0009756)1.94874061
64Polycythemia (HP:0001901)1.94335659
65Lower limb hyperreflexia (HP:0002395)1.93680587
66Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.92037536
67Acute necrotizing encephalopathy (HP:0006965)1.91377736
68Nemaline bodies (HP:0003798)1.90876362
69Lip pit (HP:0100267)1.90393073
70Methylmalonic acidemia (HP:0002912)1.87698469
71Rhabdomyosarcoma (HP:0002859)1.85142507
72Cerebral edema (HP:0002181)1.84923601
73Steatorrhea (HP:0002570)1.84655799
74Abnormality of the intrinsic pathway (HP:0010989)1.83075820
75Gout (HP:0001997)1.81176323
76Median cleft lip (HP:0000161)1.80470279
77Erythroderma (HP:0001019)1.80039771
78Increased hepatocellular lipid droplets (HP:0006565)1.79985358
79Ankle contracture (HP:0006466)1.79443235
80Neck muscle weakness (HP:0000467)1.79412890
81Patchy hypopigmentation of hair (HP:0011365)1.78904644
82Congenital, generalized hypertrichosis (HP:0004540)1.78707714
83Abnormal hemoglobin (HP:0011902)1.78633384
84Abnormal pupillary function (HP:0007686)1.78524505
85Scotoma (HP:0000575)1.77740000
86Progressive macrocephaly (HP:0004481)1.76236090
87Increased CSF lactate (HP:0002490)1.75296745
88Testicular atrophy (HP:0000029)1.74834934
89Lipid accumulation in hepatocytes (HP:0006561)1.73836247
90Muscle fiber inclusion bodies (HP:0100299)1.73771347
91Abnormal mitochondria in muscle tissue (HP:0008316)1.72701169
92Distal arthrogryposis (HP:0005684)1.72357190
93Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70679178
94Abnormality of vitamin B metabolism (HP:0004340)1.70303010
95Congenital ichthyosiform erythroderma (HP:0007431)1.67744039
96Adrenal hypoplasia (HP:0000835)1.67656975
97Aplasia/hypoplasia of the uterus (HP:0008684)1.66611099
98Abnormality of macular pigmentation (HP:0008002)1.65647985
99Sensory axonal neuropathy (HP:0003390)1.65205029
100Hyperglycinuria (HP:0003108)1.65117884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.34062527
2EIF2AK33.86649388
3MST43.69027279
4SCYL22.92079601
5EIF2AK12.70842975
6MST1R2.47267415
7BUB12.39578154
8MAP3K122.22700107
9NEK12.15402995
10NME22.15112487
11BMPR1B2.07305235
12TSSK62.00041913
13NUAK11.92153295
14BRSK21.89573229
15TRIM281.87609389
16FLT31.86813183
17TGFBR11.82490191
18WEE11.78652564
19BCKDK1.74001139
20TTK1.69154622
21LATS11.63759300
22PLK41.56922276
23MET1.56427334
24ERBB31.42903072
25MYLK1.42378520
26BMPR21.41729790
27PLK31.38089104
28VRK21.37294968
29EPHA21.37025141
30MKNK11.31607575
31RPS6KB21.27893241
32TAOK31.24124930
33STK161.23936372
34MAP4K21.21429635
35NEK91.17381026
36STK31.09565290
37ACVR1B1.08064272
38EIF2AK21.07696617
39CDK81.07485614
40NLK1.03606702
41KIT1.02940804
42MAPKAPK31.02711657
43TAF11.02518076
44CLK11.01647942
45MAP3K61.01064508
46PAK41.00964196
47SRPK11.00781368
48MKNK20.99650696
49PDK20.94580912
50PRKG20.94281632
51TRPM70.86811301
52STK38L0.85441355
53CDK30.78530385
54GRK10.77718891
55FER0.76410575
56PLK10.75982442
57PINK10.75532654
58PLK20.72907349
59MAPK70.72474150
60LIMK10.71540372
61ERBB40.69754209
62OBSCN0.64899867
63MAP3K30.62615848
64STK390.62244683
65BRSK10.61876973
66MAP2K30.60938057
67PASK0.58168749
68SIK30.55962486
69LMTK20.55821213
70VRK10.55621090
71TIE10.54496340
72FRK0.52519634
73PTK20.51667218
74RPS6KA40.50686652
75BCR0.48032002
76STK100.47981245
77DAPK10.47029122
78CDK90.45402306
79ZAK0.45382745
80OXSR10.45294400
81ABL20.44653901
82CDK60.42957237
83PAK20.39241374
84STK40.39080724
85FGFR10.38094924
86AURKB0.36985216
87WNK30.36952485
88CSF1R0.35854829
89PRKCE0.34921838
90CSNK1G10.34496866
91TBK10.33953996
92ILK0.33941863
93CDK70.30305551
94MAP2K60.30077756
95TGFBR20.29347165
96CSNK2A10.29253945
97CDC70.27464551
98PNCK0.25602019
99STK240.24715398
100PRKCI0.23163876

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.34967050
2Fatty acid elongation_Homo sapiens_hsa000622.82204280
3Protein export_Homo sapiens_hsa030602.74128841
4Propanoate metabolism_Homo sapiens_hsa006402.51691049
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35398580
6DNA replication_Homo sapiens_hsa030302.33973990
7Non-homologous end-joining_Homo sapiens_hsa034502.27402750
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20654635
9Mismatch repair_Homo sapiens_hsa034302.14581294
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05435060
11Vitamin B6 metabolism_Homo sapiens_hsa007501.98572409
12RNA degradation_Homo sapiens_hsa030181.84029366
13Glutathione metabolism_Homo sapiens_hsa004801.81726548
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.77850817
15Pyruvate metabolism_Homo sapiens_hsa006201.61943990
16N-Glycan biosynthesis_Homo sapiens_hsa005101.60108267
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60082924
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59567922
19Sulfur metabolism_Homo sapiens_hsa009201.59063267
20One carbon pool by folate_Homo sapiens_hsa006701.57825403
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57357052
22RNA transport_Homo sapiens_hsa030131.54734964
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53569047
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53156990
25Homologous recombination_Homo sapiens_hsa034401.50415179
26Peroxisome_Homo sapiens_hsa041461.46494047
27Nucleotide excision repair_Homo sapiens_hsa034201.46004977
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45865643
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44788892
30Retinol metabolism_Homo sapiens_hsa008301.43451761
31Carbon metabolism_Homo sapiens_hsa012001.39800212
32Fatty acid degradation_Homo sapiens_hsa000711.38363369
33Base excision repair_Homo sapiens_hsa034101.37388503
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34586304
35Pyrimidine metabolism_Homo sapiens_hsa002401.34393437
36Fanconi anemia pathway_Homo sapiens_hsa034601.26939247
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25806966
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20067197
39RNA polymerase_Homo sapiens_hsa030201.18017766
40Chemical carcinogenesis_Homo sapiens_hsa052041.17730597
41Ribosome_Homo sapiens_hsa030101.17233432
42Fatty acid metabolism_Homo sapiens_hsa012121.12304894
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10515188
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.08455854
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03184337
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01794607
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98758836
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98397986
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97130965
50Butanoate metabolism_Homo sapiens_hsa006500.93459544
51Selenocompound metabolism_Homo sapiens_hsa004500.93038765
52Purine metabolism_Homo sapiens_hsa002300.92159552
53p53 signaling pathway_Homo sapiens_hsa041150.92141335
54Basal transcription factors_Homo sapiens_hsa030220.91178633
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.90218995
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89379349
57Arachidonic acid metabolism_Homo sapiens_hsa005900.87598966
58beta-Alanine metabolism_Homo sapiens_hsa004100.85462722
59Folate biosynthesis_Homo sapiens_hsa007900.84361743
60Tryptophan metabolism_Homo sapiens_hsa003800.83493686
61Metabolic pathways_Homo sapiens_hsa011000.80876619
62Linoleic acid metabolism_Homo sapiens_hsa005910.79963431
63Cell cycle_Homo sapiens_hsa041100.78005945
64Biosynthesis of amino acids_Homo sapiens_hsa012300.77169563
65Sphingolipid metabolism_Homo sapiens_hsa006000.76187818
66Arginine and proline metabolism_Homo sapiens_hsa003300.75256035
67Pentose phosphate pathway_Homo sapiens_hsa000300.74474934
68Caffeine metabolism_Homo sapiens_hsa002320.73948843
69Starch and sucrose metabolism_Homo sapiens_hsa005000.73907444
70Vitamin digestion and absorption_Homo sapiens_hsa049770.73824720
71Steroid biosynthesis_Homo sapiens_hsa001000.73410446
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.72878076
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72560813
74Ether lipid metabolism_Homo sapiens_hsa005650.72372949
75Spliceosome_Homo sapiens_hsa030400.69916181
76Asthma_Homo sapiens_hsa053100.67056032
77Legionellosis_Homo sapiens_hsa051340.66864491
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66387500
79Tyrosine metabolism_Homo sapiens_hsa003500.65284253
80Parkinsons disease_Homo sapiens_hsa050120.62923670
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55416408
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53420653
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.52548370
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52301558
85Oxidative phosphorylation_Homo sapiens_hsa001900.48856176
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47296092
87Nitrogen metabolism_Homo sapiens_hsa009100.43717934
88Fat digestion and absorption_Homo sapiens_hsa049750.43342984
89Phenylalanine metabolism_Homo sapiens_hsa003600.39361395
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36957185
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34706917
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33778100
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.32403951
94Antigen processing and presentation_Homo sapiens_hsa046120.31724331
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.31166038
96Huntingtons disease_Homo sapiens_hsa050160.29734011
97Histidine metabolism_Homo sapiens_hsa003400.29667714
98Arginine biosynthesis_Homo sapiens_hsa002200.29331937
99Complement and coagulation cascades_Homo sapiens_hsa046100.27662691
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27639860

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