

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.08524758 |
| 2 | ribosome assembly (GO:0042255) | 4.68607046 |
| 3 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.85869250 |
| 4 | toxin transport (GO:1901998) | 3.80252166 |
| 5 | peptidyl-proline hydroxylation (GO:0019511) | 3.73700017 |
| 6 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.71411581 |
| 7 | ribosomal large subunit biogenesis (GO:0042273) | 3.66092611 |
| 8 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.60955460 |
| 9 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.59319628 |
| 10 | protein hydroxylation (GO:0018126) | 3.57759159 |
| 11 | AMP metabolic process (GO:0046033) | 3.48652821 |
| 12 | formation of translation preinitiation complex (GO:0001731) | 3.46080719 |
| 13 | 4-hydroxyproline metabolic process (GO:0019471) | 3.45970414 |
| 14 | response to nitric oxide (GO:0071731) | 3.41924337 |
| 15 | cullin deneddylation (GO:0010388) | 3.40565330 |
| 16 | carnitine transmembrane transport (GO:1902603) | 3.40257532 |
| 17 | IMP biosynthetic process (GO:0006188) | 3.37539106 |
| 18 | IMP metabolic process (GO:0046040) | 3.36841506 |
| 19 | branched-chain amino acid catabolic process (GO:0009083) | 3.35935929 |
| 20 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.35482505 |
| 21 | negative regulation of ligase activity (GO:0051352) | 3.35482505 |
| 22 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.30134425 |
| 23 | labyrinthine layer development (GO:0060711) | 3.27869149 |
| 24 | carnitine transport (GO:0015879) | 3.25782646 |
| 25 | amino-acid betaine transport (GO:0015838) | 3.25782646 |
| 26 | response to nitrosative stress (GO:0051409) | 3.25282714 |
| 27 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.24802103 |
| 28 | xenobiotic catabolic process (GO:0042178) | 3.23461170 |
| 29 | synapsis (GO:0007129) | 3.11139035 |
| 30 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) | 3.08667250 |
| 31 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.05785413 |
| 32 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 3.05725769 |
| 33 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.05164182 |
| 34 | protein deneddylation (GO:0000338) | 3.05110798 |
| 35 | glycerol ether metabolic process (GO:0006662) | 3.04122670 |
| 36 | ether lipid metabolic process (GO:0046485) | 3.03427863 |
| 37 | purine nucleotide salvage (GO:0032261) | 3.03042017 |
| 38 | CENP-A containing nucleosome assembly (GO:0034080) | 3.02678864 |
| 39 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.98412169 |
| 40 | positive regulation of ligase activity (GO:0051351) | 2.93671267 |
| 41 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.91216250 |
| 42 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.86026529 |
| 43 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.86026529 |
| 44 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.86026529 |
| 45 | L-methionine salvage (GO:0071267) | 2.85956176 |
| 46 | L-methionine biosynthetic process (GO:0071265) | 2.85956176 |
| 47 | amino acid salvage (GO:0043102) | 2.85956176 |
| 48 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.85699440 |
| 49 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.85699440 |
| 50 | rRNA modification (GO:0000154) | 2.83871832 |
| 51 | mitotic G2 DNA damage checkpoint (GO:0007095) | 2.82447053 |
| 52 | tricarboxylic acid cycle (GO:0006099) | 2.80658777 |
| 53 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.78668870 |
| 54 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.77464833 |
| 55 | quaternary ammonium group transport (GO:0015697) | 2.75002576 |
| 56 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.74422797 |
| 57 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.74422797 |
| 58 | mitotic G2/M transition checkpoint (GO:0044818) | 2.72164297 |
| 59 | protein maturation by protein folding (GO:0022417) | 2.70560623 |
| 60 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.70438295 |
| 61 | chromatin remodeling at centromere (GO:0031055) | 2.69904845 |
| 62 | ether metabolic process (GO:0018904) | 2.68983619 |
| 63 | purine nucleobase biosynthetic process (GO:0009113) | 2.67677770 |
| 64 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.66953499 |
| 65 | desmosome organization (GO:0002934) | 2.65322604 |
| 66 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253) | 2.65073293 |
| 67 | response to X-ray (GO:0010165) | 2.64866576 |
| 68 | rRNA methylation (GO:0031167) | 2.64538620 |
| 69 | histone exchange (GO:0043486) | 2.62521153 |
| 70 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.62511241 |
| 71 | glutathione derivative biosynthetic process (GO:1901687) | 2.62412167 |
| 72 | glutathione derivative metabolic process (GO:1901685) | 2.62412167 |
| 73 | regulation of ligase activity (GO:0051340) | 2.62286651 |
| 74 | branched-chain amino acid metabolic process (GO:0009081) | 2.57925548 |
| 75 | ribosomal small subunit assembly (GO:0000028) | 2.56294140 |
| 76 | establishment of integrated proviral latency (GO:0075713) | 2.54332444 |
| 77 | telomere maintenance via recombination (GO:0000722) | 2.53049324 |
| 78 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.52153710 |
| 79 | maturation of 5.8S rRNA (GO:0000460) | 2.50708649 |
| 80 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.50493523 |
| 81 | negative regulation of signal transduction by p53 class mediator (GO:1901797) | 2.49380004 |
| 82 | cell cycle G1/S phase transition (GO:0044843) | 2.49326041 |
| 83 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.49326041 |
| 84 | piRNA metabolic process (GO:0034587) | 2.46953752 |
| 85 | oxidative phosphorylation (GO:0006119) | 2.46047905 |
| 86 | hepatocyte differentiation (GO:0070365) | 2.42472292 |
| 87 | nucleobase biosynthetic process (GO:0046112) | 2.38778453 |
| 88 | peptidyl-histidine modification (GO:0018202) | 2.38686822 |
| 89 | mitotic metaphase plate congression (GO:0007080) | 2.37524311 |
| 90 | mitotic spindle checkpoint (GO:0071174) | 2.35690741 |
| 91 | mitotic recombination (GO:0006312) | 2.35129551 |
| 92 | negative regulation of protein ubiquitination (GO:0031397) | 2.33594123 |
| 93 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.33111446 |
| 94 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.33111446 |
| 95 | isotype switching (GO:0045190) | 2.33111446 |
| 96 | regulation of cellular amine metabolic process (GO:0033238) | 2.32583079 |
| 97 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.32173106 |
| 98 | purine-containing compound salvage (GO:0043101) | 2.31552498 |
| 99 | organic cation transport (GO:0015695) | 2.30801231 |
| 100 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288) | 2.30785764 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.84029719 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.55562569 |
| 3 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.18556514 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.16508159 |
| 5 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.94926595 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.84488360 |
| 7 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.82666249 |
| 8 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.51807796 |
| 9 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.39563867 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.37182157 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.29911496 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.16569722 |
| 13 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.06777788 |
| 14 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.00529995 |
| 15 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.99403780 |
| 16 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.96330543 |
| 17 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.93918297 |
| 18 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.90188651 |
| 19 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.88604816 |
| 20 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.88198360 |
| 21 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.88062159 |
| 22 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.85989697 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.83638083 |
| 24 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.79931322 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.75913182 |
| 26 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.74156968 |
| 27 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.73400865 |
| 28 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.72889903 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.68848653 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.65044118 |
| 31 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.64598566 |
| 32 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.60241973 |
| 33 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.60019851 |
| 34 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.58994284 |
| 35 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.58770578 |
| 36 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.57081048 |
| 37 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.52050769 |
| 38 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.50811404 |
| 39 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.49491486 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.48988107 |
| 41 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.48683955 |
| 42 | FUS_26573619_Chip-Seq_HEK293_Human | 1.48667139 |
| 43 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.48121302 |
| 44 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.44109891 |
| 45 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.43678046 |
| 46 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.40214280 |
| 47 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.39895098 |
| 48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.34473055 |
| 49 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.31864507 |
| 50 | VDR_22108803_ChIP-Seq_LS180_Human | 1.30060152 |
| 51 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.28805770 |
| 52 | * FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.27738717 |
| 53 | EWS_26573619_Chip-Seq_HEK293_Human | 1.22998790 |
| 54 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.22925111 |
| 55 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.22677588 |
| 56 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.22677588 |
| 57 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.21762781 |
| 58 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.21303424 |
| 59 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.19955415 |
| 60 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.19511459 |
| 61 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.16788381 |
| 62 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.14958087 |
| 63 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.14830135 |
| 64 | GATA1_22025678_ChIP-Seq_K562_Human | 1.11914133 |
| 65 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.09665198 |
| 66 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.09376697 |
| 67 | * GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.09129919 |
| 68 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.08905922 |
| 69 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.08162352 |
| 70 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.07537318 |
| 71 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.04782430 |
| 72 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.04050472 |
| 73 | * SOX2_20726797_ChIP-Seq_SW620_Human | 1.03751294 |
| 74 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.02565165 |
| 75 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.02453137 |
| 76 | * ELF5_23300383_ChIP-Seq_T47D_Human | 1.02365412 |
| 77 | CJUN_26792858_Chip-Seq_BT549_Human | 1.02000291 |
| 78 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.00866429 |
| 79 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.98343481 |
| 80 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.98337997 |
| 81 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.97336510 |
| 82 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.97336510 |
| 83 | AR_20517297_ChIP-Seq_VCAP_Human | 0.96596310 |
| 84 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.95721919 |
| 85 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.94684253 |
| 86 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.93899182 |
| 87 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.93851433 |
| 88 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.93422153 |
| 89 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.91691747 |
| 90 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.91556444 |
| 91 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.91554845 |
| 92 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.91056319 |
| 93 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.90019350 |
| 94 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.88257085 |
| 95 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.87479742 |
| 96 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.86829641 |
| 97 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.86643751 |
| 98 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.86461340 |
| 99 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.86113703 |
| 100 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.85907082 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 4.68641896 |
| 2 | MP0003941_abnormal_skin_development | 2.83316251 |
| 3 | MP0009697_abnormal_copulation | 2.63387505 |
| 4 | MP0010678_abnormal_skin_adnexa | 2.42311708 |
| 5 | MP0000383_abnormal_hair_follicle | 2.32359103 |
| 6 | MP0008058_abnormal_DNA_repair | 2.26764280 |
| 7 | MP0002396_abnormal_hematopoietic_system | 2.20557032 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.18838467 |
| 9 | MP0006054_spinal_hemorrhage | 2.15840886 |
| 10 | MP0000013_abnormal_adipose_tissue | 2.12551570 |
| 11 | MP0003786_premature_aging | 2.05008885 |
| 12 | MP0010234_abnormal_vibrissa_follicle | 2.04976671 |
| 13 | MP0010094_abnormal_chromosome_stability | 2.02109755 |
| 14 | MP0002132_abnormal_respiratory_system | 2.00076506 |
| 15 | MP0002796_impaired_skin_barrier | 1.99629720 |
| 16 | MP0000372_irregular_coat_pigmentation | 1.89951064 |
| 17 | MP0010352_gastrointestinal_tract_polyps | 1.86954880 |
| 18 | MP0008007_abnormal_cellular_replicative | 1.78802463 |
| 19 | MP0003718_maternal_effect | 1.77017313 |
| 20 | MP0006036_abnormal_mitochondrial_physio | 1.75600929 |
| 21 | MP0004484_altered_response_of | 1.75598230 |
| 22 | MP0003186_abnormal_redox_activity | 1.72899755 |
| 23 | MP0003950_abnormal_plasma_membrane | 1.70564558 |
| 24 | MP0002138_abnormal_hepatobiliary_system | 1.69637489 |
| 25 | MP0001661_extended_life_span | 1.59865904 |
| 26 | MP0005275_abnormal_skin_tensile | 1.59115314 |
| 27 | MP0000762_abnormal_tongue_morphology | 1.58462996 |
| 28 | MP0005084_abnormal_gallbladder_morpholo | 1.58187253 |
| 29 | MP0004264_abnormal_extraembryonic_tissu | 1.56738695 |
| 30 | MP0005330_cardiomyopathy | 1.56150340 |
| 31 | MP0002060_abnormal_skin_morphology | 1.55087262 |
| 32 | MP0004782_abnormal_surfactant_physiolog | 1.38826635 |
| 33 | MP0004233_abnormal_muscle_weight | 1.36251654 |
| 34 | MP0010368_abnormal_lymphatic_system | 1.36245699 |
| 35 | MP0000749_muscle_degeneration | 1.32450845 |
| 36 | MP0009780_abnormal_chondrocyte_physiolo | 1.30941090 |
| 37 | MP0004272_abnormal_basement_membrane | 1.30305414 |
| 38 | MP0003077_abnormal_cell_cycle | 1.25743520 |
| 39 | MP0003252_abnormal_bile_duct | 1.23683307 |
| 40 | MP0005165_increased_susceptibility_to | 1.23382857 |
| 41 | MP0000678_abnormal_parathyroid_gland | 1.22872696 |
| 42 | MP0008932_abnormal_embryonic_tissue | 1.22448816 |
| 43 | MP0003111_abnormal_nucleus_morphology | 1.21728174 |
| 44 | MP0001216_abnormal_epidermal_layer | 1.19231538 |
| 45 | MP0005332_abnormal_amino_acid | 1.18610705 |
| 46 | MP0003191_abnormal_cellular_cholesterol | 1.16316722 |
| 47 | MP0008875_abnormal_xenobiotic_pharmacok | 1.13853584 |
| 48 | MP0004215_abnormal_myocardial_fiber | 1.12132081 |
| 49 | MP0003943_abnormal_hepatobiliary_system | 1.11782811 |
| 50 | MP0005501_abnormal_skin_physiology | 1.11272151 |
| 51 | MP0008877_abnormal_DNA_methylation | 1.11215382 |
| 52 | MP0005075_abnormal_melanosome_morpholog | 1.10849338 |
| 53 | MP0002006_tumorigenesis | 1.09154202 |
| 54 | MP0004808_abnormal_hematopoietic_stem | 1.09018184 |
| 55 | MP0004084_abnormal_cardiac_muscle | 1.07122397 |
| 56 | MP0003693_abnormal_embryo_hatching | 1.06346243 |
| 57 | MP0002139_abnormal_hepatobiliary_system | 1.06010505 |
| 58 | MP0000613_abnormal_salivary_gland | 1.05964722 |
| 59 | MP0002254_reproductive_system_inflammat | 1.04887072 |
| 60 | MP0005023_abnormal_wound_healing | 1.03955984 |
| 61 | MP0002160_abnormal_reproductive_system | 1.02295902 |
| 62 | MP0005408_hypopigmentation | 1.02003541 |
| 63 | MP0000579_abnormal_nail_morphology | 1.00935753 |
| 64 | MP0001243_abnormal_dermal_layer | 0.95908064 |
| 65 | MP0001764_abnormal_homeostasis | 0.94877621 |
| 66 | MP0002166_altered_tumor_susceptibility | 0.94841047 |
| 67 | MP0010771_integument_phenotype | 0.94466600 |
| 68 | MP0002877_abnormal_melanocyte_morpholog | 0.87800135 |
| 69 | MP0009643_abnormal_urine_homeostasis | 0.87631692 |
| 70 | MP0002837_dystrophic_cardiac_calcinosis | 0.87271894 |
| 71 | MP0002282_abnormal_trachea_morphology | 0.86625110 |
| 72 | MP0005083_abnormal_biliary_tract | 0.86209538 |
| 73 | MP0000627_abnormal_mammary_gland | 0.86104084 |
| 74 | MP0000465_gastrointestinal_hemorrhage | 0.84061531 |
| 75 | MP0005360_urolithiasis | 0.83391946 |
| 76 | MP0001881_abnormal_mammary_gland | 0.83211229 |
| 77 | MP0000350_abnormal_cell_proliferation | 0.83079126 |
| 78 | MP0005380_embryogenesis_phenotype | 0.82306765 |
| 79 | MP0001672_abnormal_embryogenesis/_devel | 0.82306765 |
| 80 | MP0000467_abnormal_esophagus_morphology | 0.81698942 |
| 81 | MP0000358_abnormal_cell_content/ | 0.80011003 |
| 82 | MP0000598_abnormal_liver_morphology | 0.79800430 |
| 83 | MP0000377_abnormal_hair_follicle | 0.79247719 |
| 84 | MP0001666_abnormal_nutrient_absorption | 0.78981947 |
| 85 | MP0003984_embryonic_growth_retardation | 0.76833079 |
| 86 | MP0004036_abnormal_muscle_relaxation | 0.75445032 |
| 87 | MP0002088_abnormal_embryonic_growth/wei | 0.75292030 |
| 88 | MP0003315_abnormal_perineum_morphology | 0.74583794 |
| 89 | MP0005085_abnormal_gallbladder_physiolo | 0.74566723 |
| 90 | MP0002269_muscular_atrophy | 0.74475391 |
| 91 | MP0001191_abnormal_skin_condition | 0.73243131 |
| 92 | MP0002086_abnormal_extraembryonic_tissu | 0.72987569 |
| 93 | MP0005367_renal/urinary_system_phenotyp | 0.72499386 |
| 94 | MP0000516_abnormal_urinary_system | 0.72499386 |
| 95 | MP0005395_other_phenotype | 0.72403643 |
| 96 | MP0009931_abnormal_skin_appearance | 0.71718008 |
| 97 | MP0000681_abnormal_thyroid_gland | 0.70888254 |
| 98 | MP0008438_abnormal_cutaneous_collagen | 0.70689332 |
| 99 | MP0001697_abnormal_embryo_size | 0.68869366 |
| 100 | MP0003566_abnormal_cell_adhesion | 0.68224717 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Onycholysis (HP:0001806) | 5.25137025 |
| 2 | Reduced antithrombin III activity (HP:0001976) | 4.30932248 |
| 3 | Type I transferrin isoform profile (HP:0003642) | 3.86362005 |
| 4 | Right ventricular cardiomyopathy (HP:0011663) | 3.74216912 |
| 5 | Palpitations (HP:0001962) | 3.49802869 |
| 6 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.39747366 |
| 7 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.39747366 |
| 8 | Abnormal protein glycosylation (HP:0012346) | 3.39747366 |
| 9 | Abnormal glycosylation (HP:0012345) | 3.39747366 |
| 10 | Hypoglycemic seizures (HP:0002173) | 3.17153068 |
| 11 | Exercise-induced muscle cramps (HP:0003710) | 2.83642531 |
| 12 | Increased serum pyruvate (HP:0003542) | 2.76338403 |
| 13 | Alopecia of scalp (HP:0002293) | 2.69091274 |
| 14 | Sparse eyelashes (HP:0000653) | 2.60919758 |
| 15 | Abnormality of glycolysis (HP:0004366) | 2.54911041 |
| 16 | Central scotoma (HP:0000603) | 2.52531712 |
| 17 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.48850262 |
| 18 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.48850262 |
| 19 | Single umbilical artery (HP:0001195) | 2.48850262 |
| 20 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.45477792 |
| 21 | Plantar hyperkeratosis (HP:0007556) | 2.44056200 |
| 22 | Metaphyseal dysplasia (HP:0100255) | 2.43232352 |
| 23 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.40101147 |
| 24 | Abnormality of methionine metabolism (HP:0010901) | 2.38829831 |
| 25 | Symptomatic seizures (HP:0011145) | 2.35726464 |
| 26 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.35645955 |
| 27 | Posterior subcapsular cataract (HP:0007787) | 2.35165395 |
| 28 | Hyperalaninemia (HP:0003348) | 2.33982985 |
| 29 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.33982985 |
| 30 | Abnormality of alanine metabolism (HP:0010916) | 2.33982985 |
| 31 | Rhabdomyolysis (HP:0003201) | 2.32063336 |
| 32 | Abnormality of the umbilical cord (HP:0010881) | 2.29841434 |
| 33 | Short middle phalanx of the 5th finger (HP:0004220) | 2.24792529 |
| 34 | Hyperammonemia (HP:0001987) | 2.21945514 |
| 35 | Conjunctival hamartoma (HP:0100780) | 2.21819806 |
| 36 | Myoglobinuria (HP:0002913) | 2.21581765 |
| 37 | Microglossia (HP:0000171) | 2.20857749 |
| 38 | Dyschromatopsia (HP:0007641) | 2.15846117 |
| 39 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.15360902 |
| 40 | B lymphocytopenia (HP:0010976) | 2.14777883 |
| 41 | Fragile nails (HP:0001808) | 2.14609031 |
| 42 | Abnormality of urine glucose concentration (HP:0011016) | 2.14332547 |
| 43 | Glycosuria (HP:0003076) | 2.14332547 |
| 44 | Palmoplantar hyperkeratosis (HP:0000972) | 2.11954791 |
| 45 | Hypoglycemic coma (HP:0001325) | 2.10225558 |
| 46 | Renal Fanconi syndrome (HP:0001994) | 2.07863398 |
| 47 | Tetraparesis (HP:0002273) | 2.07447333 |
| 48 | Amniotic constriction ring (HP:0009775) | 2.06811712 |
| 49 | Abnormality of placental membranes (HP:0011409) | 2.06811712 |
| 50 | Abnormality of serum amino acid levels (HP:0003112) | 2.06651259 |
| 51 | Palmar hyperkeratosis (HP:0010765) | 2.03777022 |
| 52 | Prolonged partial thromboplastin time (HP:0003645) | 2.03103408 |
| 53 | Intrahepatic cholestasis (HP:0001406) | 2.01806600 |
| 54 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.01581259 |
| 55 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.01258126 |
| 56 | Abnormality of B cell number (HP:0010975) | 2.01068670 |
| 57 | Loss of speech (HP:0002371) | 1.99477777 |
| 58 | Acute encephalopathy (HP:0006846) | 1.99081170 |
| 59 | Lethargy (HP:0001254) | 1.97165998 |
| 60 | Abnormal auditory evoked potentials (HP:0006958) | 1.95980256 |
| 61 | Hypoplasia of the uterus (HP:0000013) | 1.95326709 |
| 62 | Confusion (HP:0001289) | 1.95162041 |
| 63 | Popliteal pterygium (HP:0009756) | 1.94874061 |
| 64 | Polycythemia (HP:0001901) | 1.94335659 |
| 65 | Lower limb hyperreflexia (HP:0002395) | 1.93680587 |
| 66 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.92037536 |
| 67 | Acute necrotizing encephalopathy (HP:0006965) | 1.91377736 |
| 68 | Nemaline bodies (HP:0003798) | 1.90876362 |
| 69 | Lip pit (HP:0100267) | 1.90393073 |
| 70 | Methylmalonic acidemia (HP:0002912) | 1.87698469 |
| 71 | Rhabdomyosarcoma (HP:0002859) | 1.85142507 |
| 72 | Cerebral edema (HP:0002181) | 1.84923601 |
| 73 | Steatorrhea (HP:0002570) | 1.84655799 |
| 74 | Abnormality of the intrinsic pathway (HP:0010989) | 1.83075820 |
| 75 | Gout (HP:0001997) | 1.81176323 |
| 76 | Median cleft lip (HP:0000161) | 1.80470279 |
| 77 | Erythroderma (HP:0001019) | 1.80039771 |
| 78 | Increased hepatocellular lipid droplets (HP:0006565) | 1.79985358 |
| 79 | Ankle contracture (HP:0006466) | 1.79443235 |
| 80 | Neck muscle weakness (HP:0000467) | 1.79412890 |
| 81 | Patchy hypopigmentation of hair (HP:0011365) | 1.78904644 |
| 82 | Congenital, generalized hypertrichosis (HP:0004540) | 1.78707714 |
| 83 | Abnormal hemoglobin (HP:0011902) | 1.78633384 |
| 84 | Abnormal pupillary function (HP:0007686) | 1.78524505 |
| 85 | Scotoma (HP:0000575) | 1.77740000 |
| 86 | Progressive macrocephaly (HP:0004481) | 1.76236090 |
| 87 | Increased CSF lactate (HP:0002490) | 1.75296745 |
| 88 | Testicular atrophy (HP:0000029) | 1.74834934 |
| 89 | Lipid accumulation in hepatocytes (HP:0006561) | 1.73836247 |
| 90 | Muscle fiber inclusion bodies (HP:0100299) | 1.73771347 |
| 91 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.72701169 |
| 92 | Distal arthrogryposis (HP:0005684) | 1.72357190 |
| 93 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.70679178 |
| 94 | Abnormality of vitamin B metabolism (HP:0004340) | 1.70303010 |
| 95 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.67744039 |
| 96 | Adrenal hypoplasia (HP:0000835) | 1.67656975 |
| 97 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.66611099 |
| 98 | Abnormality of macular pigmentation (HP:0008002) | 1.65647985 |
| 99 | Sensory axonal neuropathy (HP:0003390) | 1.65205029 |
| 100 | Hyperglycinuria (HP:0003108) | 1.65117884 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PBK | 5.34062527 |
| 2 | EIF2AK3 | 3.86649388 |
| 3 | MST4 | 3.69027279 |
| 4 | SCYL2 | 2.92079601 |
| 5 | EIF2AK1 | 2.70842975 |
| 6 | MST1R | 2.47267415 |
| 7 | BUB1 | 2.39578154 |
| 8 | MAP3K12 | 2.22700107 |
| 9 | NEK1 | 2.15402995 |
| 10 | NME2 | 2.15112487 |
| 11 | BMPR1B | 2.07305235 |
| 12 | TSSK6 | 2.00041913 |
| 13 | NUAK1 | 1.92153295 |
| 14 | BRSK2 | 1.89573229 |
| 15 | TRIM28 | 1.87609389 |
| 16 | FLT3 | 1.86813183 |
| 17 | TGFBR1 | 1.82490191 |
| 18 | WEE1 | 1.78652564 |
| 19 | BCKDK | 1.74001139 |
| 20 | TTK | 1.69154622 |
| 21 | LATS1 | 1.63759300 |
| 22 | PLK4 | 1.56922276 |
| 23 | MET | 1.56427334 |
| 24 | ERBB3 | 1.42903072 |
| 25 | MYLK | 1.42378520 |
| 26 | BMPR2 | 1.41729790 |
| 27 | PLK3 | 1.38089104 |
| 28 | VRK2 | 1.37294968 |
| 29 | EPHA2 | 1.37025141 |
| 30 | MKNK1 | 1.31607575 |
| 31 | RPS6KB2 | 1.27893241 |
| 32 | TAOK3 | 1.24124930 |
| 33 | STK16 | 1.23936372 |
| 34 | MAP4K2 | 1.21429635 |
| 35 | NEK9 | 1.17381026 |
| 36 | STK3 | 1.09565290 |
| 37 | ACVR1B | 1.08064272 |
| 38 | EIF2AK2 | 1.07696617 |
| 39 | CDK8 | 1.07485614 |
| 40 | NLK | 1.03606702 |
| 41 | KIT | 1.02940804 |
| 42 | MAPKAPK3 | 1.02711657 |
| 43 | TAF1 | 1.02518076 |
| 44 | CLK1 | 1.01647942 |
| 45 | MAP3K6 | 1.01064508 |
| 46 | PAK4 | 1.00964196 |
| 47 | SRPK1 | 1.00781368 |
| 48 | MKNK2 | 0.99650696 |
| 49 | PDK2 | 0.94580912 |
| 50 | PRKG2 | 0.94281632 |
| 51 | TRPM7 | 0.86811301 |
| 52 | STK38L | 0.85441355 |
| 53 | CDK3 | 0.78530385 |
| 54 | GRK1 | 0.77718891 |
| 55 | FER | 0.76410575 |
| 56 | PLK1 | 0.75982442 |
| 57 | PINK1 | 0.75532654 |
| 58 | PLK2 | 0.72907349 |
| 59 | MAPK7 | 0.72474150 |
| 60 | LIMK1 | 0.71540372 |
| 61 | ERBB4 | 0.69754209 |
| 62 | OBSCN | 0.64899867 |
| 63 | MAP3K3 | 0.62615848 |
| 64 | STK39 | 0.62244683 |
| 65 | BRSK1 | 0.61876973 |
| 66 | MAP2K3 | 0.60938057 |
| 67 | PASK | 0.58168749 |
| 68 | SIK3 | 0.55962486 |
| 69 | LMTK2 | 0.55821213 |
| 70 | VRK1 | 0.55621090 |
| 71 | TIE1 | 0.54496340 |
| 72 | FRK | 0.52519634 |
| 73 | PTK2 | 0.51667218 |
| 74 | RPS6KA4 | 0.50686652 |
| 75 | BCR | 0.48032002 |
| 76 | STK10 | 0.47981245 |
| 77 | DAPK1 | 0.47029122 |
| 78 | CDK9 | 0.45402306 |
| 79 | ZAK | 0.45382745 |
| 80 | OXSR1 | 0.45294400 |
| 81 | ABL2 | 0.44653901 |
| 82 | CDK6 | 0.42957237 |
| 83 | PAK2 | 0.39241374 |
| 84 | STK4 | 0.39080724 |
| 85 | FGFR1 | 0.38094924 |
| 86 | AURKB | 0.36985216 |
| 87 | WNK3 | 0.36952485 |
| 88 | CSF1R | 0.35854829 |
| 89 | PRKCE | 0.34921838 |
| 90 | CSNK1G1 | 0.34496866 |
| 91 | TBK1 | 0.33953996 |
| 92 | ILK | 0.33941863 |
| 93 | CDK7 | 0.30305551 |
| 94 | MAP2K6 | 0.30077756 |
| 95 | TGFBR2 | 0.29347165 |
| 96 | CSNK2A1 | 0.29253945 |
| 97 | CDC7 | 0.27464551 |
| 98 | PNCK | 0.25602019 |
| 99 | STK24 | 0.24715398 |
| 100 | PRKCI | 0.23163876 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.34967050 |
| 2 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.82204280 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.74128841 |
| 4 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.51691049 |
| 5 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.35398580 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.33973990 |
| 7 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.27402750 |
| 8 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.20654635 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.14581294 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.05435060 |
| 11 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.98572409 |
| 12 | RNA degradation_Homo sapiens_hsa03018 | 1.84029366 |
| 13 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.81726548 |
| 14 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.77850817 |
| 15 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.61943990 |
| 16 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.60108267 |
| 17 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.60082924 |
| 18 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.59567922 |
| 19 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.59063267 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.57825403 |
| 21 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.57357052 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.54734964 |
| 23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.53569047 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.53156990 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 1.50415179 |
| 26 | Peroxisome_Homo sapiens_hsa04146 | 1.46494047 |
| 27 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.46004977 |
| 28 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.45865643 |
| 29 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.44788892 |
| 30 | Retinol metabolism_Homo sapiens_hsa00830 | 1.43451761 |
| 31 | Carbon metabolism_Homo sapiens_hsa01200 | 1.39800212 |
| 32 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.38363369 |
| 33 | Base excision repair_Homo sapiens_hsa03410 | 1.37388503 |
| 34 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.34586304 |
| 35 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.34393437 |
| 36 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.26939247 |
| 37 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.25806966 |
| 38 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.20067197 |
| 39 | RNA polymerase_Homo sapiens_hsa03020 | 1.18017766 |
| 40 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.17730597 |
| 41 | Ribosome_Homo sapiens_hsa03010 | 1.17233432 |
| 42 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.12304894 |
| 43 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.10515188 |
| 44 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.08455854 |
| 45 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.03184337 |
| 46 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.01794607 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.98758836 |
| 48 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.98397986 |
| 49 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.97130965 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.93459544 |
| 51 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.93038765 |
| 52 | Purine metabolism_Homo sapiens_hsa00230 | 0.92159552 |
| 53 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.92141335 |
| 54 | Basal transcription factors_Homo sapiens_hsa03022 | 0.91178633 |
| 55 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.90218995 |
| 56 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.89379349 |
| 57 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.87598966 |
| 58 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.85462722 |
| 59 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.84361743 |
| 60 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.83493686 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.80876619 |
| 62 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.79963431 |
| 63 | Cell cycle_Homo sapiens_hsa04110 | 0.78005945 |
| 64 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.77169563 |
| 65 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.76187818 |
| 66 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.75256035 |
| 67 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74474934 |
| 68 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.73948843 |
| 69 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.73907444 |
| 70 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.73824720 |
| 71 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.73410446 |
| 72 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.72878076 |
| 73 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.72560813 |
| 74 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.72372949 |
| 75 | Spliceosome_Homo sapiens_hsa03040 | 0.69916181 |
| 76 | Asthma_Homo sapiens_hsa05310 | 0.67056032 |
| 77 | Legionellosis_Homo sapiens_hsa05134 | 0.66864491 |
| 78 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.66387500 |
| 79 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.65284253 |
| 80 | Parkinsons disease_Homo sapiens_hsa05012 | 0.62923670 |
| 81 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.55416408 |
| 82 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.53420653 |
| 83 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.52548370 |
| 84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.52301558 |
| 85 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.48856176 |
| 86 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.47296092 |
| 87 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.43717934 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.43342984 |
| 89 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.39361395 |
| 90 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.36957185 |
| 91 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.34706917 |
| 92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.33778100 |
| 93 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.32403951 |
| 94 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.31724331 |
| 95 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.31166038 |
| 96 | Huntingtons disease_Homo sapiens_hsa05016 | 0.29734011 |
| 97 | Histidine metabolism_Homo sapiens_hsa00340 | 0.29667714 |
| 98 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.29331937 |
| 99 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.27662691 |
| 100 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.27639860 |

