SYS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.94248105
2viral transcription (GO:0019083)5.87062909
3translational termination (GO:0006415)5.67263235
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.61112541
5cotranslational protein targeting to membrane (GO:0006613)5.54977879
6protein targeting to ER (GO:0045047)5.52317047
7protein localization to endoplasmic reticulum (GO:0070972)5.38809331
8ribosomal small subunit assembly (GO:0000028)5.31108175
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.27519201
10ribosomal small subunit biogenesis (GO:0042274)5.03125333
11translational elongation (GO:0006414)4.81362573
12viral life cycle (GO:0019058)4.42825641
13signal peptide processing (GO:0006465)4.23123218
14translational initiation (GO:0006413)4.20881543
15cellular protein complex disassembly (GO:0043624)4.20461690
16proteasome assembly (GO:0043248)4.18931553
17ribosomal large subunit biogenesis (GO:0042273)4.17450661
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.02373090
19translation (GO:0006412)3.88520601
20protein targeting to membrane (GO:0006612)3.80195950
21chaperone-mediated protein transport (GO:0072321)3.73745928
22maturation of SSU-rRNA (GO:0030490)3.66017988
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65725018
24GDP-mannose metabolic process (GO:0019673)3.62805079
25iron-sulfur cluster assembly (GO:0016226)3.59921367
26metallo-sulfur cluster assembly (GO:0031163)3.59921367
27regulation of cilium movement (GO:0003352)3.55890883
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.55793246
29protein complex disassembly (GO:0043241)3.54007499
30neutrophil activation involved in immune response (GO:0002283)3.52913114
31response to interferon-beta (GO:0035456)3.46056188
32axonemal dynein complex assembly (GO:0070286)3.44047783
33UDP-N-acetylglucosamine metabolic process (GO:0006047)3.39103541
34L-phenylalanine metabolic process (GO:0006558)3.36916185
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36916185
36macromolecular complex disassembly (GO:0032984)3.36012946
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.34292185
38termination of RNA polymerase III transcription (GO:0006386)3.34292185
39L-methionine salvage (GO:0071267)3.32733599
40L-methionine biosynthetic process (GO:0071265)3.32733599
41amino acid salvage (GO:0043102)3.32733599
42kynurenine metabolic process (GO:0070189)3.31331330
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29953527
44GMP metabolic process (GO:0046037)3.29539074
45respiratory chain complex IV assembly (GO:0008535)3.27405902
46L-serine metabolic process (GO:0006563)3.26422345
47mannosylation (GO:0097502)3.19354287
48macrophage differentiation (GO:0030225)3.18698587
49regulation of mitochondrial translation (GO:0070129)3.10703857
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.04616418
51L-phenylalanine catabolic process (GO:0006559)3.04616418
52tryptophan catabolic process (GO:0006569)3.01849423
53indole-containing compound catabolic process (GO:0042436)3.01849423
54indolalkylamine catabolic process (GO:0046218)3.01849423
55response to xenobiotic stimulus (GO:0009410)3.01475297
56pseudouridine synthesis (GO:0001522)3.00175489
57negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.99748914
58central nervous system myelination (GO:0022010)2.99591836
59axon ensheathment in central nervous system (GO:0032291)2.99591836
60protein targeting to mitochondrion (GO:0006626)2.99145831
61heme biosynthetic process (GO:0006783)2.98502852
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.97845559
63serine family amino acid biosynthetic process (GO:0009070)2.92066647
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88991919
65guanosine-containing compound biosynthetic process (GO:1901070)2.87545032
66ribonucleoprotein complex biogenesis (GO:0022613)2.86818264
67pteridine-containing compound biosynthetic process (GO:0042559)2.86653248
68epithelial cilium movement (GO:0003351)2.85254673
69pyrimidine-containing compound transmembrane transport (GO:0072531)2.84836859
70nuclear-transcribed mRNA catabolic process (GO:0000956)2.84293660
71protein targeting (GO:0006605)2.82466168
72establishment of protein localization to mitochondrion (GO:0072655)2.81456253
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80978324
74protein import into peroxisome matrix (GO:0016558)2.78271009
75folic acid transport (GO:0015884)2.77585047
76response to peptidoglycan (GO:0032494)2.77343977
77establishment of protein localization to membrane (GO:0090150)2.75908307
78cilium or flagellum-dependent cell motility (GO:0001539)2.75655937
79cellular copper ion homeostasis (GO:0006878)2.75279190
80positive regulation of tolerance induction (GO:0002645)2.74886826
81oligosaccharide catabolic process (GO:0009313)2.74528921
82nucleotide-sugar biosynthetic process (GO:0009226)2.74189343
83dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.73357194
84C-terminal protein lipidation (GO:0006501)2.73330562
85cilium movement (GO:0003341)2.73287544
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73075039
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73075039
88ATP synthesis coupled proton transport (GO:0015986)2.71799531
89energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71799531
90folic acid metabolic process (GO:0046655)2.71558991
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.71312511
92cellular component biogenesis (GO:0044085)2.71287865
93regulation of cellular amino acid metabolic process (GO:0006521)2.71201934
94cellular response to type I interferon (GO:0071357)2.69878982
95type I interferon signaling pathway (GO:0060337)2.69878982
96amyloid precursor protein catabolic process (GO:0042987)2.69840642
97mRNA catabolic process (GO:0006402)2.69769340
98copper ion homeostasis (GO:0055070)2.69669867
99nucleotide transmembrane transport (GO:1901679)2.69040175
100cellular metabolic compound salvage (GO:0043094)2.68649310
101GTP biosynthetic process (GO:0006183)2.68438887
102modulation by virus of host process (GO:0019054)2.67984678
103cytochrome complex assembly (GO:0017004)2.67128944
104protein deneddylation (GO:0000338)2.66535504
105regulation of podosome assembly (GO:0071801)2.66040060
106neutrophil activation (GO:0042119)2.65174461
107regulation of interferon-alpha production (GO:0032647)2.64588928
108cellular response to arsenic-containing substance (GO:0071243)2.63371070
109response to type I interferon (GO:0034340)2.62445718
110amino sugar catabolic process (GO:0046348)2.62094335
111mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60966670
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60656216
113negative regulation of ligase activity (GO:0051352)2.60656216
114autophagic vacuole fusion (GO:0000046)2.60518519
115glycine metabolic process (GO:0006544)2.59440758
116CTP metabolic process (GO:0046036)2.59322570
117CTP biosynthetic process (GO:0006241)2.59322570
118regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.58234335
119epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56128653
120regulation of RIG-I signaling pathway (GO:0039535)2.55579833
121protein complex biogenesis (GO:0070271)2.55259209
122heme metabolic process (GO:0042168)2.54990948
123protein localization to mitochondrion (GO:0070585)2.54315463
124establishment of protein localization to organelle (GO:0072594)2.54047050
125deoxyribonucleotide catabolic process (GO:0009264)2.53449148
126GPI anchor biosynthetic process (GO:0006506)2.51822129
127protein maturation by protein folding (GO:0022417)2.51208742
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51198506
129regulation of tolerance induction (GO:0002643)2.50969657
130RNA catabolic process (GO:0006401)2.50963784
131granulocyte activation (GO:0036230)2.50784464
132antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49863163
133cellular response to zinc ion (GO:0071294)2.49064588
134purine deoxyribonucleotide catabolic process (GO:0009155)2.48839489
135positive regulation of toll-like receptor signaling pathway (GO:0034123)2.47558092
136amyloid precursor protein metabolic process (GO:0042982)2.47268198
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47212533
138regulation of retinoic acid receptor signaling pathway (GO:0048385)2.47179789
139rRNA processing (GO:0006364)2.45808625
140respiratory electron transport chain (GO:0022904)2.45685505
141protein retention in ER lumen (GO:0006621)2.44865810
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44573362
143preassembly of GPI anchor in ER membrane (GO:0016254)2.44482975
144tryptophan metabolic process (GO:0006568)2.44101673
145regulation of chemokine biosynthetic process (GO:0045073)2.43236452
146protein targeting to peroxisome (GO:0006625)2.41877249
147establishment of protein localization to peroxisome (GO:0072663)2.41877249
148protein localization to peroxisome (GO:0072662)2.41877249
149negative regulation of viral entry into host cell (GO:0046597)2.41531107
150peroxisomal transport (GO:0043574)2.41418980
151regulation of metalloenzyme activity (GO:0048552)2.41385292
152mitochondrial respiratory chain complex assembly (GO:0033108)2.40913845
153copper ion transport (GO:0006825)2.40550175
154deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.40540963
155positive regulation of interferon-alpha production (GO:0032727)2.39657643
156positive regulation of interferon-beta production (GO:0032728)2.39587455
157mitochondrion degradation (GO:0000422)2.38848261
158negative regulation of chemokine production (GO:0032682)2.37348144
159cellular biogenic amine catabolic process (GO:0042402)2.37214815
160amine catabolic process (GO:0009310)2.37214815
161signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36969241
162intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36969241
163branching involved in labyrinthine layer morphogenesis (GO:0060670)2.36895927
164cullin deneddylation (GO:0010388)2.36751013
165G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.36636211
166base-excision repair, AP site formation (GO:0006285)2.35922213
167negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.34744818
168transcription from mitochondrial promoter (GO:0006390)2.34578580
169membrane lipid catabolic process (GO:0046466)2.33560208
170signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.33538634
171signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.33538634
172signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.33538634
173C-terminal protein amino acid modification (GO:0018410)2.33488926
174nonribosomal peptide biosynthetic process (GO:0019184)2.32178230
175sphingolipid catabolic process (GO:0030149)2.31612159
176phosphatidylinositol acyl-chain remodeling (GO:0036149)2.31149561
177negative regulation of T cell differentiation in thymus (GO:0033085)2.30338365
178nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.30294970
179glycosphingolipid catabolic process (GO:0046479)2.30068690
180regulation of T cell tolerance induction (GO:0002664)2.30019253
181negative regulation of protein autophosphorylation (GO:0031953)2.29069823
182positive regulation of protein homooligomerization (GO:0032464)2.28639528
183negative regulation of nitric oxide biosynthetic process (GO:0045019)2.27474189
184DNA catabolic process, exonucleolytic (GO:0000738)2.26973704
185regulation of transforming growth factor beta2 production (GO:0032909)2.26702755
186negative regulation of cell killing (GO:0031342)2.26171074
187negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26171074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.92252248
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.61005580
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42211196
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40315281
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.37525323
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.04819774
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.99807297
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93678420
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.79522410
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75557445
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60733321
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.54948649
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46902700
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46693476
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27678805
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27421033
17* VDR_23849224_ChIP-Seq_CD4+_Human2.25477213
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18147801
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14541016
20* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13857449
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11266968
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.10713804
23XRN2_22483619_ChIP-Seq_HELA_Human2.08408806
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06785379
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03274241
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00809986
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00363660
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98628752
29* GABP_19822575_ChIP-Seq_HepG2_Human1.96117364
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95512909
31DCP1A_22483619_ChIP-Seq_HELA_Human1.93953351
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92718592
33TFEB_21752829_ChIP-Seq_HELA_Human1.85654102
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85461295
35ELK1_19687146_ChIP-ChIP_HELA_Human1.83667326
36ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.79515641
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78499326
38FOXP3_21729870_ChIP-Seq_TREG_Human1.78076276
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76854558
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76679158
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.73222670
42* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71962112
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71107165
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70218818
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.67993879
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64365231
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60987110
48VDR_21846776_ChIP-Seq_THP-1_Human1.60217136
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57503086
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54333635
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.51457573
52* RXR_22158963_ChIP-Seq_LIVER_Mouse1.51214338
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46716928
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.46137086
55* ELF5_23300383_ChIP-Seq_T47D_Human1.45043998
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43549693
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43531017
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43465094
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42454499
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41989863
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41620366
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41112330
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40734191
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.39072337
65* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38464029
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38248430
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37799562
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37614936
69* SPI1_23547873_ChIP-Seq_NB4_Human1.36240563
70TTF2_22483619_ChIP-Seq_HELA_Human1.33388980
71* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33194406
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33087710
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31129479
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29381897
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28966818
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28084957
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26876945
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26194594
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24580790
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.24122401
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.23862451
82CIITA_25753668_ChIP-Seq_RAJI_Human1.23162916
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22920581
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22768136
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21959752
86GATA3_26560356_Chip-Seq_TH2_Human1.21293413
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21046622
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.20938717
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20866997
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19579168
91MAF_26560356_Chip-Seq_TH2_Human1.19477828
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19050211
93KDM5A_27292631_Chip-Seq_BREAST_Human1.18476820
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.13974369
95MYC_22102868_ChIP-Seq_BL_Human1.12664054
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.12630700
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.12493943
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12314322
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12253294
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12029765
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11045934
102SOX2_20726797_ChIP-Seq_SW620_Human1.08627027
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08426383
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08124422
105VDR_24763502_ChIP-Seq_THP-1_Human1.07417364
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07266938
107AR_20517297_ChIP-Seq_VCAP_Human1.07147801
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06791817
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06574680
110SCL_19346495_ChIP-Seq_HPC-7_Human1.06353233
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05901461
112STAT1_20625510_ChIP-Seq_HELA_Human1.05152212
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05058945
114FOXP1_21924763_ChIP-Seq_HESCs_Human1.04721388
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04349188
116GATA4_25053715_ChIP-Seq_YYC3_Human1.04259416
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04088809
118MYC_18940864_ChIP-ChIP_HL60_Human1.03952865
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03680951
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03090392
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03071734
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02687243
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02611307
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02209876
125BCOR_27268052_Chip-Seq_Bcells_Human1.01821497
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01487060
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01332474
128ESR1_21235772_ChIP-Seq_MCF-7_Human1.01081803
129PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01075028
130* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99672040
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.99313245
132MAF_26560356_Chip-Seq_TH1_Human0.99123565
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98961102
134MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98204133
135* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97767739
136STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94046696
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92223741
138MYB_26560356_Chip-Seq_TH2_Human0.92179014
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90730651
140* LXR_22158963_ChIP-Seq_LIVER_Mouse0.89347664
141ZNF274_21170338_ChIP-Seq_K562_Hela0.87904864
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86831237
143ESR2_21235772_ChIP-Seq_MCF-7_Human0.85046476
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84591157
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84499423
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84172221
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83150804
148JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81226030
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80799911
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78825689
151RUNX_20019798_ChIP-Seq_JUKART_Human0.76037929
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75303985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell5.13364895
2MP0002139_abnormal_hepatobiliary_system2.88999169
3MP0003806_abnormal_nucleotide_metabolis2.62221878
4MP0000685_abnormal_immune_system2.62012957
5MP0005083_abnormal_biliary_tract2.46206218
6MP0005365_abnormal_bile_salt2.45746562
7MP0003195_calcinosis2.37566984
8MP0001666_abnormal_nutrient_absorption2.31202643
9MP0003011_delayed_dark_adaptation2.23504810
10MP0003186_abnormal_redox_activity2.17751962
11MP0005058_abnormal_lysosome_morphology2.14878185
12MP0005671_abnormal_response_to2.12397849
13MP0009379_abnormal_foot_pigmentation2.06240966
14MP0003252_abnormal_bile_duct2.04140658
15MP0009333_abnormal_splenocyte_physiolog2.00636154
16MP0004381_abnormal_hair_follicle1.99872301
17MP0008260_abnormal_autophagy1.97476376
18MP0003693_abnormal_embryo_hatching1.95666441
19MP0003724_increased_susceptibility_to1.90254191
20MP0003866_abnormal_defecation1.89675792
21MP0003656_abnormal_erythrocyte_physiolo1.89497269
22MP0009785_altered_susceptibility_to1.89098641
23MP0005360_urolithiasis1.83492018
24MP0005332_abnormal_amino_acid1.82001789
25MP0001764_abnormal_homeostasis1.81382560
26MP0002132_abnormal_respiratory_system1.78834021
27MP0006054_spinal_hemorrhage1.77560242
28MP0005387_immune_system_phenotype1.74868850
29MP0001790_abnormal_immune_system1.74868850
30MP0001835_abnormal_antigen_presentation1.72881351
31MP0005220_abnormal_exocrine_pancreas1.70280058
32MP0006036_abnormal_mitochondrial_physio1.70224018
33MP0001533_abnormal_skeleton_physiology1.69675736
34MP0009764_decreased_sensitivity_to1.68936285
35MP0005085_abnormal_gallbladder_physiolo1.68550748
36MP0005025_abnormal_response_to1.64081569
37MP0005451_abnormal_body_composition1.60256722
38MP0005084_abnormal_gallbladder_morpholo1.59921820
39MP0002723_abnormal_immune_serum1.59040245
40MP0003763_abnormal_thymus_physiology1.58092219
41MP0003191_abnormal_cellular_cholesterol1.54247920
42MP0001800_abnormal_humoral_immune1.54072925
43MP0010234_abnormal_vibrissa_follicle1.49871958
44MP0004264_abnormal_extraembryonic_tissu1.47859456
45MP0005000_abnormal_immune_tolerance1.47518975
46MP0000920_abnormal_myelination1.47129723
47MP0003868_abnormal_feces_composition1.46955224
48MP0002277_abnormal_respiratory_mucosa1.46383796
49MP0000343_altered_response_to1.45917209
50MP0008875_abnormal_xenobiotic_pharmacok1.45017613
51MP0000490_abnormal_crypts_of1.43712137
52MP0002420_abnormal_adaptive_immunity1.42951268
53MP0010386_abnormal_urinary_bladder1.42585680
54MP0002332_abnormal_exercise_endurance1.40140145
55MP0001819_abnormal_immune_cell1.39605211
56MP0001873_stomach_inflammation1.39126722
57MP0008469_abnormal_protein_level1.39044582
58MP0009115_abnormal_fat_cell1.37942883
59MP0005075_abnormal_melanosome_morpholog1.37736307
60MP0002452_abnormal_antigen_presenting1.37506123
61MP0009643_abnormal_urine_homeostasis1.37336763
62MP0002254_reproductive_system_inflammat1.35972471
63MP0005636_abnormal_mineral_homeostasis1.35454948
64MP0003300_gastrointestinal_ulcer1.34922784
65MP0004043_abnormal_pH_regulation1.34211656
66MP0006082_CNS_inflammation1.33945912
67MP0001727_abnormal_embryo_implantation1.32412074
68MP0003786_premature_aging1.29619322
69MP0000716_abnormal_immune_system1.29399762
70MP0001853_heart_inflammation1.29156271
71MP0003075_altered_response_to1.29102272
72MP0002398_abnormal_bone_marrow1.28791370
73MP0000689_abnormal_spleen_morphology1.28663833
74MP0002693_abnormal_pancreas_physiology1.26843603
75MP0000465_gastrointestinal_hemorrhage1.26646628
76MP0005164_abnormal_response_to1.25397364
77MP0003436_decreased_susceptibility_to1.22826625
78MP0000609_abnormal_liver_physiology1.21946507
79MP0002419_abnormal_innate_immunity1.21894554
80MP0002429_abnormal_blood_cell1.21205523
81MP0002928_abnormal_bile_duct1.20271775
82MP0003303_peritoneal_inflammation1.16842872
83MP0003172_abnormal_lysosome_physiology1.16760946
84MP0003136_yellow_coat_color1.16644723
85MP0005310_abnormal_salivary_gland1.16248502
86MP0002722_abnormal_immune_system1.16220230
87MP0002118_abnormal_lipid_homeostasis1.15456887
88MP0000858_altered_metastatic_potential1.14891457
89MP0004957_abnormal_blastocyst_morpholog1.14783719
90MP0002148_abnormal_hypersensitivity_rea1.14139598
91MP0001845_abnormal_inflammatory_respons1.14019541
92MP0005464_abnormal_platelet_physiology1.13020927
93MP0003329_amyloid_beta_deposits1.10631364
94MP0003718_maternal_effect1.10469312
95MP0004019_abnormal_vitamin_homeostasis1.10119665
96MP0002405_respiratory_system_inflammati1.09862339
97MP0010155_abnormal_intestine_physiology1.09209402
98MP0000613_abnormal_salivary_gland1.07965245
99MP0001944_abnormal_pancreas_morphology1.06811425
100MP0000372_irregular_coat_pigmentation1.06688576
101MP0002653_abnormal_ependyma_morphology1.05601383
102MP0005584_abnormal_enzyme/coenzyme_acti1.05012113
103MP0001663_abnormal_digestive_system1.01502409
104MP0004133_heterotaxia1.01083534
105MP0002638_abnormal_pupillary_reflex1.00771201
106MP0001851_eye_inflammation0.99409058
107MP0010678_abnormal_skin_adnexa0.98606647
108MP0005381_digestive/alimentary_phenotyp0.98011867
109MP0008873_increased_physiological_sensi0.97914004
110MP0001661_extended_life_span0.94433527
111MP0005376_homeostasis/metabolism_phenot0.93044204
112MP0004142_abnormal_muscle_tone0.92164760
113MP0000427_abnormal_hair_cycle0.90255165
114MP0005408_hypopigmentation0.86888866
115MP0002396_abnormal_hematopoietic_system0.86775655
116MP0005165_increased_susceptibility_to0.86646486
117MP0002933_joint_inflammation0.85970620
118MP0002138_abnormal_hepatobiliary_system0.84917965
119MP0005319_abnormal_enzyme/_coenzyme0.84544905
120MP0009765_abnormal_xenobiotic_induced0.84269170
121MP0001905_abnormal_dopamine_level0.83870154
122MP0009642_abnormal_blood_homeostasis0.82811002
123MP0000703_abnormal_thymus_morphology0.81532659
124MP0004147_increased_porphyrin_level0.80703946
125MP0010329_abnormal_lipoprotein_level0.79944275
126MP0006035_abnormal_mitochondrial_morpho0.79723334
127MP0005379_endocrine/exocrine_gland_phen0.79465028
128MP0004947_skin_inflammation0.79253477
129MP0000358_abnormal_cell_content/0.77435119
130MP0000598_abnormal_liver_morphology0.77274125
131MP0001756_abnormal_urination0.76934857
132MP0006072_abnormal_retinal_apoptosis0.76925249
133MP0000604_amyloidosis0.76877936
134MP0005023_abnormal_wound_healing0.75439232
135MP0002136_abnormal_kidney_physiology0.74712475
136MP0009763_increased_sensitivity_to0.74446337
137MP0001324_abnormal_eye_pigmentation0.73038704

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.42985350
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.29661489
3Abnormal number of erythroid precursors (HP:0012131)4.24047484
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.92788894
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.92788894
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.72981288
7Abnormal respiratory epithelium morphology (HP:0012253)3.65193765
8Abnormal respiratory motile cilium morphology (HP:0005938)3.65193765
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.64992147
10Absent/shortened dynein arms (HP:0200106)3.64992147
11Macrocytic anemia (HP:0001972)3.64794876
12Abnormality of liposaccharide metabolism (HP:0010968)3.63373679
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.63373679
14Abnormality of glycolipid metabolism (HP:0010969)3.63373679
15Hepatocellular necrosis (HP:0001404)3.53164911
16Rhinitis (HP:0012384)3.50129797
17Hepatic necrosis (HP:0002605)3.45147685
18Abnormal ciliary motility (HP:0012262)3.44950010
19Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.44849614
20Abnormal respiratory motile cilium physiology (HP:0012261)3.36771851
21Cerebral hypomyelination (HP:0006808)3.27105903
223-Methylglutaconic aciduria (HP:0003535)3.22901247
23Orchitis (HP:0100796)3.14094324
24Retrobulbar optic neuritis (HP:0100654)3.04662720
25Optic neuritis (HP:0100653)3.04662720
26Loss of speech (HP:0002371)3.02250184
27Reticulocytopenia (HP:0001896)2.99976861
28Mitochondrial inheritance (HP:0001427)2.99217183
29Vacuolated lymphocytes (HP:0001922)2.96917390
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.89974972
31Spastic paraparesis (HP:0002313)2.79558495
32Myositis (HP:0100614)2.76715709
33Pallor (HP:0000980)2.76327505
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75095486
35Split foot (HP:0001839)2.74130383
36Stomatitis (HP:0010280)2.73933251
37Increased IgM level (HP:0003496)2.72830093
38Increased cerebral lipofuscin (HP:0011813)2.71211997
39Acute necrotizing encephalopathy (HP:0006965)2.70834031
40Progressive muscle weakness (HP:0003323)2.70768764
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70537053
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67919159
43Abnormal mitochondria in muscle tissue (HP:0008316)2.65522057
44Tetraparesis (HP:0002273)2.64077156
45Chronic otitis media (HP:0000389)2.62681471
46Brushfield spots (HP:0001088)2.61902459
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.61684591
48Recurrent abscess formation (HP:0002722)2.59047330
49Acute encephalopathy (HP:0006846)2.58433231
50Recurrent bacterial skin infections (HP:0005406)2.56565920
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56558529
52Agnosia (HP:0010524)2.56474312
53Hypoplasia of the uterus (HP:0000013)2.56465807
54Nasal polyposis (HP:0100582)2.54231191
55Type I transferrin isoform profile (HP:0003642)2.53941671
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52344962
57Increased CSF lactate (HP:0002490)2.49758052
58Increased intramyocellular lipid droplets (HP:0012240)2.48134179
59Aplastic anemia (HP:0001915)2.45907518
60Petechiae (HP:0000967)2.45743489
61Increased serum lactate (HP:0002151)2.45073141
62Poor head control (HP:0002421)2.44393768
63Systemic lupus erythematosus (HP:0002725)2.42428318
64Xanthomatosis (HP:0000991)2.41901286
65Progressive neurologic deterioration (HP:0002344)2.37888907
66Disinhibition (HP:0000734)2.36732075
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36428097
68Abnormal protein N-linked glycosylation (HP:0012347)2.36428097
69Abnormal protein glycosylation (HP:0012346)2.36428097
70Abnormal glycosylation (HP:0012345)2.36428097
71Bronchiectasis (HP:0002110)2.35122487
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34633012
73Dicarboxylic aciduria (HP:0003215)2.34633012
74Prolonged neonatal jaundice (HP:0006579)2.34618194
75Axonal loss (HP:0003447)2.33871745
76Reduced antithrombin III activity (HP:0001976)2.33844471
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.32815705
78Increased muscle lipid content (HP:0009058)2.32407289
79Hyperlipoproteinemia (HP:0010980)2.31141421
80Lactic acidosis (HP:0003128)2.29265866
81Renal Fanconi syndrome (HP:0001994)2.27600320
82Abnormality of macrophages (HP:0004311)2.26767888
83Generalized aminoaciduria (HP:0002909)2.25880963
84Abnormality of T cell physiology (HP:0011840)2.25733694
85Hyperglycinemia (HP:0002154)2.25442115
86IgM deficiency (HP:0002850)2.23885843
87CNS hypomyelination (HP:0003429)2.23338092
88Increased hepatocellular lipid droplets (HP:0006565)2.23129194
89Eczematoid dermatitis (HP:0000976)2.22029051
90Lipid accumulation in hepatocytes (HP:0006561)2.19154588
91Abnormality of fatty-acid metabolism (HP:0004359)2.19144529
92Lethargy (HP:0001254)2.16528030
93Megaloblastic anemia (HP:0001889)2.14515544
94Acute hepatic failure (HP:0006554)2.13892135
95Microretrognathia (HP:0000308)2.13764533
96CNS demyelination (HP:0007305)2.12610842
97Secondary amenorrhea (HP:0000869)2.11855920
98Abnormality of the nasal mucosa (HP:0000433)2.11247337
99Respiratory failure (HP:0002878)2.10112654
100Increased serum ferritin (HP:0003281)2.09803195
101Polyneuropathy (HP:0001271)2.09557672
102Purpura (HP:0000979)2.09391851
103Chronic sinusitis (HP:0011109)2.08952890
104Elevated erythrocyte sedimentation rate (HP:0003565)2.08896867
105Upper motor neuron abnormality (HP:0002127)2.08882606
106Cerebral edema (HP:0002181)2.07781075
107Abnormal rod and cone electroretinograms (HP:0008323)2.07491587
108Anorexia (HP:0002039)2.04278196
109Aplasia/hypoplasia of the uterus (HP:0008684)2.02904115
110Recurrent gram-negative bacterial infections (HP:0005420)2.02350195
111Chronic bronchitis (HP:0004469)2.00988067
112Medial flaring of the eyebrow (HP:0010747)2.00665561
113Methylmalonic aciduria (HP:0012120)1.96960640
114Abnormality of serine family amino acid metabolism (HP:0010894)1.95295583
115Abnormality of glycine metabolism (HP:0010895)1.95295583
116Paraparesis (HP:0002385)1.94766583
117Nuclear cataract (HP:0100018)1.94255674
118Tubulointerstitial nephritis (HP:0001970)1.93929983
119Hypoglycemic coma (HP:0001325)1.93767235
120Personality changes (HP:0000751)1.93543948
121Neurofibrillary tangles (HP:0002185)1.93183593
122Progressive macrocephaly (HP:0004481)1.92241925
123Abnormality of serum amino acid levels (HP:0003112)1.92183735
124Tubulointerstitial fibrosis (HP:0005576)1.90953997
125Dysostosis multiplex (HP:0000943)1.90578766
126Pancytopenia (HP:0001876)1.90371269
127Opisthotonus (HP:0002179)1.89166093
128Tubulointerstitial abnormality (HP:0001969)1.88039415
129Pulmonary infiltrates (HP:0002113)1.87243619
130Panhypogammaglobulinemia (HP:0003139)1.86534341
131IgG deficiency (HP:0004315)1.86084365
132Hypokinesia (HP:0002375)1.85874078
133Hyperphosphaturia (HP:0003109)1.84139547
134Amyloidosis (HP:0011034)1.83951222
135Prolonged partial thromboplastin time (HP:0003645)1.83741849
136Vascular calcification (HP:0004934)1.82933396
137Delayed CNS myelination (HP:0002188)1.82534460
138Glomerulonephritis (HP:0000099)1.81646014
139Exertional dyspnea (HP:0002875)1.79592148
140Abnormality of the pericardium (HP:0001697)1.79465218
141Adrenal hypoplasia (HP:0000835)1.78889820
142Leukodystrophy (HP:0002415)1.78596846
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78040354
144Microcytic anemia (HP:0001935)1.77950719
145Entropion (HP:0000621)1.77751895
146Abnormal delayed hypersensitivity skin test (HP:0002963)1.77537159
147Male infertility (HP:0003251)1.77254616
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.77121084
149Premature ovarian failure (HP:0008209)1.76822577
150Rough bone trabeculation (HP:0100670)1.75807195
151Delusions (HP:0000746)1.75666216
152Abnormality of T cells (HP:0002843)1.75139655
153Emotional lability (HP:0000712)1.74756608
154Microvesicular hepatic steatosis (HP:0001414)1.74130331
155Intrahepatic cholestasis (HP:0001406)1.73782087
156Hepatosplenomegaly (HP:0001433)1.72759417
157Choroideremia (HP:0001139)1.71605700
158Hypoglycemic seizures (HP:0002173)1.71195271
159True hermaphroditism (HP:0010459)1.71183644
160Posterior subcapsular cataract (HP:0007787)1.70867733
161Gangrene (HP:0100758)1.70536221
162Keratoconjunctivitis (HP:0001096)1.69452282
163Congenital sensorineural hearing impairment (HP:0008527)1.69088972
164Congenital primary aphakia (HP:0007707)1.67210236
165Keratoconjunctivitis sicca (HP:0001097)1.66257329
166Recurrent skin infections (HP:0001581)1.63512542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.32227312
2BCKDK3.87717801
3TESK23.64017726
4STK163.41453535
5BUB13.23123461
6TLK13.21497256
7TRIM283.11419185
8MST42.89795874
9EIF2AK12.76079198
10MAP4K12.70795391
11PDK22.62664627
12SIK32.56651214
13CDK192.35457892
14DYRK32.27511811
15TGFBR22.12946542
16ERN12.11791341
17BLK2.06067501
18EIF2AK32.01117954
19MST1R1.99533288
20MAP4K21.92225837
21FRK1.84767141
22KDR1.84262435
23RIPK11.77733524
24IRAK41.77106151
25EPHB11.73725034
26MAP3K121.73233763
27MAP2K21.72979563
28IRAK31.72726999
29WEE11.72241244
30EPHA31.69412285
31PIM21.67092692
32VRK21.64535462
33ACVR1B1.63360765
34NME11.58883509
35MAP3K111.52389811
36NEK61.51120158
37STK101.45976267
38BMPR1B1.40884892
39MAPKAPK51.39135523
40GRK71.32913440
41ZAP701.32610558
42FLT31.31170108
43INSRR1.27550310
44TBK11.22981430
45MAPK151.21073847
46ERBB41.19648722
47PBK1.17356307
48SCYL21.15524257
49RPS6KA41.13568411
50BTK1.10752462
51MUSK1.10236654
52VRK11.10195419
53MAP3K31.08506708
54JAK11.08153553
55IRAK11.07864145
56ARAF1.07604715
57NLK1.06245971
58STK391.06124019
59BRAF1.04953070
60CDK81.01735300
61ERBB30.99229743
62TEC0.98447370
63MAP3K140.95775729
64DYRK20.94162491
65TXK0.93097943
66KIT0.93027178
67GRK60.92535527
68RPS6KA50.87750053
69CLK10.86568922
70TNIK0.86341870
71ABL20.83818455
72TYK20.83818358
73IKBKE0.81820492
74TIE10.78440497
75TAOK30.76226390
76IRAK20.75879540
77EPHA20.75754513
78PINK10.75603256
79MAPKAPK30.73816326
80SYK0.72083301
81MAP2K30.71713915
82PLK30.71578437
83DYRK1B0.70693130
84DAPK30.70623444
85YES10.70210786
86HIPK20.70037920
87IKBKB0.69604976
88GRK10.69059702
89CSF1R0.67017953
90LIMK10.66487433
91CHUK0.65870427
92MAP3K100.64992698
93ILK0.64567181
94LRRK20.63440803
95AURKA0.62304259
96LYN0.59864136
97BRSK20.59846172
98MAP3K20.58997468
99PRKD20.57270094
100PAK10.56135483
101FER0.55258562
102FES0.54858120
103FGFR40.54825767
104JAK30.53842822
105ADRBK10.53651910
106BCR0.53512251
107PIK3CG0.52802611
108LCK0.52119746
109TESK10.51184728
110CSNK1A1L0.51057929
111CSNK1G30.49991933
112WNK40.49774804
113SRPK10.48713378
114MKNK20.48367957
115NUAK10.46929479
116LMTK20.46099245
117CAMK2B0.45695899
118MAPK40.45664450
119MAPK120.44968661
120MAPK110.44657795
121CAMK2G0.44483100
122HCK0.44086979
123CAMKK20.43400241
124MAP3K10.42281025
125OXSR10.41941472
126PRKCE0.40683658
127PIK3CA0.40017882
128RAF10.39536326
129PRKCI0.39099525
130JAK20.38336001
131ABL10.37447153
132ADRBK20.37418253
133MAP2K60.36685297
134PRKG20.36470479
135TAOK10.36289494
136RPS6KB20.35605240
137PAK40.35588460
138MELK0.35131077
139MOS0.34980031
140MAP3K80.34910108
141MAP3K50.34249891
142TRPM70.33645089
143CSNK1G10.33487240
144PRKCD0.31719356
145CSK0.31525272
146MAPKAPK20.31196820
147PASK0.30725174
148PRKCQ0.30466900
149FGFR20.30310651

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.98867220
2Protein export_Homo sapiens_hsa030604.03132092
3Folate biosynthesis_Homo sapiens_hsa007903.42678054
4Proteasome_Homo sapiens_hsa030503.06816127
5RNA polymerase_Homo sapiens_hsa030202.57817197
6Sulfur relay system_Homo sapiens_hsa041222.53213232
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.30140216
8Oxidative phosphorylation_Homo sapiens_hsa001902.07715529
9Pyrimidine metabolism_Homo sapiens_hsa002401.97389134
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95444032
11Parkinsons disease_Homo sapiens_hsa050121.90250345
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88843461
13Fatty acid elongation_Homo sapiens_hsa000621.82551654
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.72532128
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70823093
16DNA replication_Homo sapiens_hsa030301.70775474
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69756649
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65027592
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62486594
20Collecting duct acid secretion_Homo sapiens_hsa049661.60425089
21Vitamin B6 metabolism_Homo sapiens_hsa007501.56317330
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55768621
23Sulfur metabolism_Homo sapiens_hsa009201.49805284
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.46247173
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44817473
26Legionellosis_Homo sapiens_hsa051341.43648123
27Steroid biosynthesis_Homo sapiens_hsa001001.42453611
28Primary immunodeficiency_Homo sapiens_hsa053401.39718509
29Staphylococcus aureus infection_Homo sapiens_hsa051501.37231966
30Regulation of autophagy_Homo sapiens_hsa041401.36762041
31Other glycan degradation_Homo sapiens_hsa005111.30683213
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30653462
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29230230
34Rheumatoid arthritis_Homo sapiens_hsa053231.28097345
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22063209
36Peroxisome_Homo sapiens_hsa041461.18931869
37Pentose phosphate pathway_Homo sapiens_hsa000301.18747319
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16209427
39Alzheimers disease_Homo sapiens_hsa050101.15553410
40Spliceosome_Homo sapiens_hsa030401.14969206
41Huntingtons disease_Homo sapiens_hsa050161.10252469
42Arginine and proline metabolism_Homo sapiens_hsa003301.09308239
43Histidine metabolism_Homo sapiens_hsa003401.09033896
44Graft-versus-host disease_Homo sapiens_hsa053321.09000219
45Complement and coagulation cascades_Homo sapiens_hsa046101.08872241
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08733907
47Fat digestion and absorption_Homo sapiens_hsa049751.08630074
48Selenocompound metabolism_Homo sapiens_hsa004501.08583684
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08315523
50Purine metabolism_Homo sapiens_hsa002301.07908383
51Base excision repair_Homo sapiens_hsa034101.07861438
52Glutathione metabolism_Homo sapiens_hsa004801.06140003
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.03860644
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01952003
55Vibrio cholerae infection_Homo sapiens_hsa051101.00122901
56Linoleic acid metabolism_Homo sapiens_hsa005910.99946884
57Autoimmune thyroid disease_Homo sapiens_hsa053200.99050137
58Homologous recombination_Homo sapiens_hsa034400.97370262
59Osteoclast differentiation_Homo sapiens_hsa043800.95918455
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94995545
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.94826350
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91934929
63Vitamin digestion and absorption_Homo sapiens_hsa049770.91522738
64Nucleotide excision repair_Homo sapiens_hsa034200.90785290
65Caffeine metabolism_Homo sapiens_hsa002320.90535075
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89918657
67TNF signaling pathway_Homo sapiens_hsa046680.89301040
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88693950
69Pertussis_Homo sapiens_hsa051330.88404372
70Metabolic pathways_Homo sapiens_hsa011000.87399039
71Mineral absorption_Homo sapiens_hsa049780.86260779
72Phagosome_Homo sapiens_hsa041450.86125597
73Mismatch repair_Homo sapiens_hsa034300.84518069
74Fructose and mannose metabolism_Homo sapiens_hsa000510.84071645
75Arachidonic acid metabolism_Homo sapiens_hsa005900.83569829
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82979705
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.79742156
78Tuberculosis_Homo sapiens_hsa051520.78843958
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77258316
80Lysosome_Homo sapiens_hsa041420.76497055
81N-Glycan biosynthesis_Homo sapiens_hsa005100.76241057
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75625187
83Chemical carcinogenesis_Homo sapiens_hsa052040.74581661
84Ether lipid metabolism_Homo sapiens_hsa005650.73204236
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.72056822
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70882812
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.69540367
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.68441431
89Type I diabetes mellitus_Homo sapiens_hsa049400.68112589
90Sphingolipid metabolism_Homo sapiens_hsa006000.68010841
91beta-Alanine metabolism_Homo sapiens_hsa004100.66080848
92Hepatitis C_Homo sapiens_hsa051600.65933925
93Basal transcription factors_Homo sapiens_hsa030220.65122086
94Fatty acid degradation_Homo sapiens_hsa000710.63630901
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63595401
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63319579
97Phenylalanine metabolism_Homo sapiens_hsa003600.62976429
98Leishmaniasis_Homo sapiens_hsa051400.62123715
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61689976
100Measles_Homo sapiens_hsa051620.61248557
101Pancreatic secretion_Homo sapiens_hsa049720.60853202
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59323841
103Tryptophan metabolism_Homo sapiens_hsa003800.58220002
104Allograft rejection_Homo sapiens_hsa053300.57882331
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57453344
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55084773
107Hepatitis B_Homo sapiens_hsa051610.53915470
108Influenza A_Homo sapiens_hsa051640.53102804
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52424162
110Retinol metabolism_Homo sapiens_hsa008300.50918735
111Butanoate metabolism_Homo sapiens_hsa006500.50905909
112RNA transport_Homo sapiens_hsa030130.50674303
113Malaria_Homo sapiens_hsa051440.50543513
114Apoptosis_Homo sapiens_hsa042100.50408390
115Asthma_Homo sapiens_hsa053100.50205050
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49551388
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49036557
118Hematopoietic cell lineage_Homo sapiens_hsa046400.48460164
119Antigen processing and presentation_Homo sapiens_hsa046120.45800171
120Propanoate metabolism_Homo sapiens_hsa006400.44797518
121Galactose metabolism_Homo sapiens_hsa000520.43575297
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42456792
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40577244
124Herpes simplex infection_Homo sapiens_hsa051680.39712795
125Glycerolipid metabolism_Homo sapiens_hsa005610.39627937
126One carbon pool by folate_Homo sapiens_hsa006700.39080154
127Biosynthesis of amino acids_Homo sapiens_hsa012300.36822806
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35889027
129Nitrogen metabolism_Homo sapiens_hsa009100.32387765
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31977932
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.31721752
132Shigellosis_Homo sapiens_hsa051310.30314682
133B cell receptor signaling pathway_Homo sapiens_hsa046620.30170913

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