ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	4.30327387
2	cullin deneddylation (GO:0010388)	4.09799278
3	positive regulation of mitochondrial fission (GO:0090141)	3.91692386
4	protein deneddylation (GO:0000338)	3.83742852
5	mannosylation (GO:0097502)	3.68706458
6	pyrimidine nucleobase catabolic process (GO:0006208)	3.62611227
7	protein localization to cilium (GO:0061512)	3.44867793
8	sequestering of actin monomers (GO:0042989)	3.30822825
9	intraciliary transport (GO:0042073)	3.30686515
10	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.28186790
11	ATP hydrolysis coupled proton transport (GO:0015991)	3.28186790
12	synaptic vesicle maturation (GO:0016188)	3.24077628
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19371662
14	nonmotile primary cilium assembly (GO:0035058)	3.15275060
15	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.15226515
16	termination of RNA polymerase III transcription (GO:0006386)	3.15226515
17	glycosphingolipid biosynthetic process (GO:0006688)	3.13557234
18	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.10534581
19	neuron cell-cell adhesion (GO:0007158)	3.07259174
20	neuronal action potential propagation (GO:0019227)	3.06950676
21	nucleobase catabolic process (GO:0046113)	3.04620443
22	metallo-sulfur cluster assembly (GO:0031163)	3.01428851
23	iron-sulfur cluster assembly (GO:0016226)	3.01428851
24	glutamate secretion (GO:0014047)	3.01238347
25	protein complex biogenesis (GO:0070271)	3.01133274
26	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.97799111
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.93665476
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.93665476
29	NADH dehydrogenase complex assembly (GO:0010257)	2.93665476
30	synaptic vesicle exocytosis (GO:0016079)	2.93291530
31	regulation of cilium movement (GO:0003352)	2.92905273
32	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.89886597
33	axonal fasciculation (GO:0007413)	2.89080986
34	short-term memory (GO:0007614)	2.88964320
35	establishment of mitochondrion localization (GO:0051654)	2.87956799
36	7-methylguanosine mRNA capping (GO:0006370)	2.87484138
37	neurofilament cytoskeleton organization (GO:0060052)	2.86880543
38	protein-cofactor linkage (GO:0018065)	2.86577388
39	synaptic transmission, glutamatergic (GO:0035249)	2.80010336
40	fatty acid elongation (GO:0030497)	2.79581027
41	7-methylguanosine RNA capping (GO:0009452)	2.78818916
42	RNA capping (GO:0036260)	2.78818916
43	inner mitochondrial membrane organization (GO:0007007)	2.77697245
44	vocalization behavior (GO:0071625)	2.77184639
45	startle response (GO:0001964)	2.76528281
46	regulation of feeding behavior (GO:0060259)	2.75013681
47	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.74902612
48	regulation of synaptic vesicle exocytosis (GO:2000300)	2.74009318
49	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.71358053
50	DNA damage response, detection of DNA damage (GO:0042769)	2.69576432
51	neuron-neuron synaptic transmission (GO:0007270)	2.69047091
52	respiratory electron transport chain (GO:0022904)	2.68610448
53	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.68090434
54	regulation of cellular amino acid metabolic process (GO:0006521)	2.67587344
55	regulation of mitochondrial fission (GO:0090140)	2.65907687
56	electron transport chain (GO:0022900)	2.65475908
57	inner ear receptor stereocilium organization (GO:0060122)	2.65290398
58	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.65223253
59	histone H2A acetylation (GO:0043968)	2.64932396
60	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.64734022
61	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.64580436
62	gamma-aminobutyric acid transport (GO:0015812)	2.63864920
63	neurotransmitter secretion (GO:0007269)	2.63326960
64	detection of calcium ion (GO:0005513)	2.62911015
65	positive regulation of TOR signaling (GO:0032008)	2.61815390
66	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58967222
67	protein K11-linked ubiquitination (GO:0070979)	2.58634438
68	platelet dense granule organization (GO:0060155)	2.56919883
69	establishment of viral latency (GO:0019043)	2.53895029
70	dendritic spine organization (GO:0097061)	2.53505337
71	de novo protein folding (GO:0006458)	2.52673768
72	protein insertion into membrane (GO:0051205)	2.52639285
73	protein localization to synapse (GO:0035418)	2.52506797
74	glutamate receptor signaling pathway (GO:0007215)	2.52427884
75	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.52074580
76	regulation of synapse structural plasticity (GO:0051823)	2.51872686
77	DNA double-strand break processing (GO:0000729)	2.51490655
78	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.50692442
79	negative regulation of ligase activity (GO:0051352)	2.50692442
80	organelle disassembly (GO:1903008)	2.50530633
81	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50065527
82	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50065527
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.49670588
84	ATP synthesis coupled proton transport (GO:0015986)	2.49319846
85	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.49319846
86	L-methionine salvage (GO:0071267)	2.47721496
87	L-methionine biosynthetic process (GO:0071265)	2.47721496
88	amino acid salvage (GO:0043102)	2.47721496
89	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.46100911
90	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.46072827
91	righting reflex (GO:0060013)	2.42852952
92	establishment of melanosome localization (GO:0032401)	2.41720621
93	C-terminal protein amino acid modification (GO:0018410)	2.41097010
94	cilium morphogenesis (GO:0060271)	2.40653007
95	regulation of mitotic spindle checkpoint (GO:1903504)	2.40438781
96	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.40438781
97	de novo posttranslational protein folding (GO:0051084)	2.40319130
98	neurotransmitter-gated ion channel clustering (GO:0072578)	2.40252015
99	negative regulation of cation channel activity (GO:2001258)	2.39846680
100	regulation of neurotransmitter uptake (GO:0051580)	2.39044502

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.70258365
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.77148571
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54295467
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.26755896
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00452826
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.87628499
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86296439
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.72952473
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.63692572
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.60649104
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.54713260
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.45666133
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42275558
14	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.31322124
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.20512790
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.14287982
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13277913
18	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.04975772
19	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.04615527
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.04311095
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.96642360
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95396795
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.88438025
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84449503
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.82602802
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.80541664
27	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.80493278
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73367484
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72105270
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71024874
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.65944422
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.62883915
33	VDR_22108803_ChIP-Seq_LS180_Human	1.61562550
34	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.60471478
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.57443196
36	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.55789091
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.55058232
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.53232349
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51384565
40	FUS_26573619_Chip-Seq_HEK293_Human	1.49866753
41	P300_19829295_ChIP-Seq_ESCs_Human	1.47743086
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40776402
43	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.39714549
44	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.39398492
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.38511374
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.37802047
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36807814
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35492689
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33862085
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30106049
51	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.26426135
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.24346600
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22200499
54	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.18993147
55	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.17379437
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.17327339
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.12973392
58	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.11968727
59	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10711492
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09648747
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07843063
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.07707286
63	EWS_26573619_Chip-Seq_HEK293_Human	1.07397402
64	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06206192
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05716255
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05693481
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05680617
68	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03396486
69	AR_25329375_ChIP-Seq_VCAP_Human	1.03084266
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01915228
71	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.00520591
72	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.99884734
73	TTF2_22483619_ChIP-Seq_HELA_Human	0.99250716
74	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.98536155
75	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.98313022
76	XRN2_22483619_ChIP-Seq_HELA_Human	0.97879847
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97309560
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.97271825
79	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.95956165
80	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.95255468
81	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94736937
82	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.92795866
83	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.91123836
84	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.91101180
85	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.90671581
86	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.88918768
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88203185
88	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.87376485
89	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.86717972
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.84869871
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.84869871
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.83893417
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.83679992
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.83521062
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.82753350
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.82080207
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.81795845
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.80955648
99	ER_23166858_ChIP-Seq_MCF-7_Human	0.80378404
100	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.79480718

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.71953247
2	MP0004270_analgesia	3.32795689
3	MP0001529_abnormal_vocalization	3.16593123
4	MP0004859_abnormal_synaptic_plasticity	3.00069834
5	MP0002822_catalepsy	2.91432404
6	MP0003122_maternal_imprinting	2.50371177
7	MP0009046_muscle_twitch	2.40051701
8	MP0000778_abnormal_nervous_system	2.26311333
9	MP0001984_abnormal_olfaction	2.23386999
10	MP0003635_abnormal_synaptic_transmissio	2.15927085
11	MP0002272_abnormal_nervous_system	2.14902291
12	MP0003121_genomic_imprinting	2.14607257
13	MP0002735_abnormal_chemical_nociception	2.13534912
14	MP0003787_abnormal_imprinting	2.09882884
15	MP0009745_abnormal_behavioral_response	2.06047743
16	MP0002653_abnormal_ependyma_morphology	2.05539176
17	MP0002734_abnormal_mechanical_nocicepti	2.00866629
18	MP0002102_abnormal_ear_morphology	1.98144987
19	MP0006276_abnormal_autonomic_nervous	1.96396463
20	MP0002064_seizures	1.87798155
21	MP0003195_calcinosis	1.86623702
22	MP0005646_abnormal_pituitary_gland	1.83562451
23	MP0001486_abnormal_startle_reflex	1.81344394
24	MP0002063_abnormal_learning/memory/cond	1.78443731
25	MP0005499_abnormal_olfactory_system	1.78335651
26	MP0005394_taste/olfaction_phenotype	1.78335651
27	MP0002572_abnormal_emotion/affect_behav	1.74259969
28	MP0005423_abnormal_somatic_nervous	1.72441272
29	MP0002638_abnormal_pupillary_reflex	1.71863162
30	MP0002837_dystrophic_cardiac_calcinosis	1.67256564
31	MP0003011_delayed_dark_adaptation	1.66422372
32	MP0001968_abnormal_touch/_nociception	1.62763210
33	MP0008877_abnormal_DNA_methylation	1.62474935
34	MP0004142_abnormal_muscle_tone	1.62399701
35	MP0006072_abnormal_retinal_apoptosis	1.60829889
36	MP0005645_abnormal_hypothalamus_physiol	1.59997619
37	MP0002736_abnormal_nociception_after	1.55668739
38	MP0008789_abnormal_olfactory_epithelium	1.54643718
39	MP0008995_early_reproductive_senescence	1.52450946
40	MP0005551_abnormal_eye_electrophysiolog	1.52343279
41	MP0008058_abnormal_DNA_repair	1.50982074
42	MP0005084_abnormal_gallbladder_morpholo	1.43229502
43	MP0005253_abnormal_eye_physiology	1.42172003
44	MP0001970_abnormal_pain_threshold	1.41921229
45	MP0000566_synostosis	1.38897250
46	MP0002067_abnormal_sensory_capabilities	1.37742585
47	MP0003786_premature_aging	1.37288419
48	MP0000631_abnormal_neuroendocrine_gland	1.35721679
49	MP0000955_abnormal_spinal_cord	1.30517688
50	MP0002733_abnormal_thermal_nociception	1.29520093
51	MP0002184_abnormal_innervation	1.28662738
52	MP0004811_abnormal_neuron_physiology	1.27990017
53	MP0002234_abnormal_pharynx_morphology	1.26485022
54	MP0006035_abnormal_mitochondrial_morpho	1.26419016
55	MP0001502_abnormal_circadian_rhythm	1.25793843
56	MP0001905_abnormal_dopamine_level	1.24943061
57	MP0002557_abnormal_social/conspecific_i	1.23713084
58	MP0002882_abnormal_neuron_morphology	1.19530298
59	MP0009780_abnormal_chondrocyte_physiolo	1.15668196
60	MP0004147_increased_porphyrin_level	1.11638454
61	MP0002752_abnormal_somatic_nervous	1.09946601
62	MP0001188_hyperpigmentation	1.07803945
63	MP0004924_abnormal_behavior	1.05643464
64	MP0005386_behavior/neurological_phenoty	1.05643464
65	MP0004742_abnormal_vestibular_system	1.05266048
66	MP0002066_abnormal_motor_capabilities/c	1.05174946
67	MP0003123_paternal_imprinting	1.04464752
68	MP0001501_abnormal_sleep_pattern	1.03804329
69	MP0000647_abnormal_sebaceous_gland	1.03363632
70	MP0002751_abnormal_autonomic_nervous	0.99698997
71	MP0006036_abnormal_mitochondrial_physio	0.99566061
72	MP0004133_heterotaxia	0.97855295
73	MP0000026_abnormal_inner_ear	0.96213378
74	MP0003119_abnormal_digestive_system	0.96068267
75	MP0003938_abnormal_ear_development	0.95620714
76	MP0001299_abnormal_eye_distance/	0.95503623
77	MP0001986_abnormal_taste_sensitivity	0.94377597
78	MP0002229_neurodegeneration	0.91376375
79	MP0002069_abnormal_eating/drinking_beha	0.91031794
80	MP0005623_abnormal_meninges_morphology	0.86358653
81	MP0005248_abnormal_Harderian_gland	0.85818670
82	MP0005451_abnormal_body_composition	0.84541697
83	MP0003137_abnormal_impulse_conducting	0.83052859
84	MP0002152_abnormal_brain_morphology	0.82007118
85	MP0004215_abnormal_myocardial_fiber	0.81920125
86	MP0002090_abnormal_vision	0.81895458
87	MP0003221_abnormal_cardiomyocyte_apopto	0.81456168
88	MP0000049_abnormal_middle_ear	0.81314753
89	MP0003718_maternal_effect	0.78760064
90	MP0001346_abnormal_lacrimal_gland	0.77250350
91	MP0005187_abnormal_penis_morphology	0.76733677
92	MP0000427_abnormal_hair_cycle	0.76122071
93	MP0003283_abnormal_digestive_organ	0.75658712
94	MP0005171_absent_coat_pigmentation	0.75393905
95	MP0001177_atelectasis	0.75037206
96	MP0001963_abnormal_hearing_physiology	0.72936363
97	MP0000372_irregular_coat_pigmentation	0.72258107
98	MP0005195_abnormal_posterior_eye	0.72200752
99	MP0002909_abnormal_adrenal_gland	0.71635837
100	MP0000749_muscle_degeneration	0.71148552

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Polyphagia (HP:0002591)	4.08628008
2	Split foot (HP:0001839)	3.97857910
3	Abnormality of glycolysis (HP:0004366)	3.40154918
4	Acute necrotizing encephalopathy (HP:0006965)	3.40005192
5	Abnormality of the labia minora (HP:0012880)	3.35135631
6	Gait imbalance (HP:0002141)	3.28930022
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.28462653
8	Medial flaring of the eyebrow (HP:0010747)	3.25519604
9	Congenital primary aphakia (HP:0007707)	3.09843210
10	Myokymia (HP:0002411)	3.02503786
11	Progressive macrocephaly (HP:0004481)	2.92298432
12	Nephrogenic diabetes insipidus (HP:0009806)	2.91983794
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.87051576
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.87051576
15	Methylmalonic acidemia (HP:0002912)	2.85748123
16	Increased serum pyruvate (HP:0003542)	2.83335956
17	Mitochondrial inheritance (HP:0001427)	2.81720873
18	Upper limb muscle weakness (HP:0003484)	2.75538877
19	Focal motor seizures (HP:0011153)	2.75118179
20	Type II lissencephaly (HP:0007260)	2.70175508
21	Acute encephalopathy (HP:0006846)	2.67286161
22	Hepatocellular necrosis (HP:0001404)	2.66937817
23	Cholecystitis (HP:0001082)	2.65357166
24	Abnormal gallbladder physiology (HP:0012438)	2.65357166
25	Retinal dysplasia (HP:0007973)	2.60638518
26	Humeroradial synostosis (HP:0003041)	2.52683087
27	Synostosis involving the elbow (HP:0003938)	2.52683087
28	Absent speech (HP:0001344)	2.52579074
29	Cerebellar dysplasia (HP:0007033)	2.49354127
30	Genital tract atresia (HP:0001827)	2.48028010
31	Hypsarrhythmia (HP:0002521)	2.47908901
32	Amyotrophic lateral sclerosis (HP:0007354)	2.45544682
33	EEG with generalized epileptiform discharges (HP:0011198)	2.44781497
34	Febrile seizures (HP:0002373)	2.44161717
35	Hepatic necrosis (HP:0002605)	2.42693047
36	Vaginal atresia (HP:0000148)	2.42539863
37	Epileptiform EEG discharges (HP:0011182)	2.42168721
38	True hermaphroditism (HP:0010459)	2.40878873
39	Abnormal eating behavior (HP:0100738)	2.39512103
40	Molar tooth sign on MRI (HP:0002419)	2.38982135
41	Abnormality of midbrain morphology (HP:0002418)	2.38982135
42	Poor suck (HP:0002033)	2.38733751
43	Shoulder girdle muscle weakness (HP:0003547)	2.38483875
44	Increased CSF lactate (HP:0002490)	2.38408496
45	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.37185773
46	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.37185773
47	Lissencephaly (HP:0001339)	2.31583472
48	Failure to thrive in infancy (HP:0001531)	2.24407973
49	Abnormality of the hip-girdle musculature (HP:0001445)	2.24107139
50	Abnormality of the musculature of the pelvis (HP:0001469)	2.24107139
51	Atonic seizures (HP:0010819)	2.23678769
52	Abnormality of the corticospinal tract (HP:0002492)	2.23109317
53	Hypoplastic pelvis (HP:0008839)	2.22297419
54	Methylmalonic aciduria (HP:0012120)	2.19535484
55	Renal cortical cysts (HP:0000803)	2.13819289
56	Postnatal microcephaly (HP:0005484)	2.12346130
57	Impaired vibration sensation in the lower limbs (HP:0002166)	2.11659137
58	Neonatal respiratory distress (HP:0002643)	2.10697345
59	Abnormal protein N-linked glycosylation (HP:0012347)	2.09956751
60	Abnormal protein glycosylation (HP:0012346)	2.09956751
61	Abnormal glycosylation (HP:0012345)	2.09956751
62	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09956751
63	Tubulointerstitial nephritis (HP:0001970)	2.09156960
64	Cerebral edema (HP:0002181)	2.06366408
65	Esotropia (HP:0000565)	2.00114651
66	Severe muscular hypotonia (HP:0006829)	1.99575329
67	Increased corneal curvature (HP:0100692)	1.99285542
68	Keratoconus (HP:0000563)	1.99285542
69	Epileptic encephalopathy (HP:0200134)	1.98674406
70	Muscular hypotonia of the trunk (HP:0008936)	1.97604699
71	Oligodactyly (hands) (HP:0001180)	1.97105040
72	Spastic gait (HP:0002064)	1.96648180
73	Generalized myoclonic seizures (HP:0002123)	1.94360825
74	Adactyly (HP:0009776)	1.94095405
75	Scrotal hypoplasia (HP:0000046)	1.94007150
76	Optic disc pallor (HP:0000543)	1.93786771
77	Specific learning disability (HP:0001328)	1.92844254
78	Increased hepatocellular lipid droplets (HP:0006565)	1.92557535
79	Hand muscle atrophy (HP:0009130)	1.91834169
80	Broad foot (HP:0001769)	1.91101093
81	Hypothermia (HP:0002045)	1.90016531
82	Urinary urgency (HP:0000012)	1.89881658
83	Type I transferrin isoform profile (HP:0003642)	1.89123059
84	Generalized tonic-clonic seizures (HP:0002069)	1.88930854
85	Tongue fasciculations (HP:0001308)	1.86054120
86	Pancreatic fibrosis (HP:0100732)	1.85822314
87	Focal seizures (HP:0007359)	1.85339809
88	Postaxial hand polydactyly (HP:0001162)	1.85254127
89	Pelvic girdle muscle weakness (HP:0003749)	1.84850021
90	Decreased testicular size (HP:0008734)	1.84830856
91	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.84778767
92	Increased intramyocellular lipid droplets (HP:0012240)	1.83863491
93	Dialeptic seizures (HP:0011146)	1.83176707
94	Lactic acidosis (HP:0003128)	1.82121414
95	Lipid accumulation in hepatocytes (HP:0006561)	1.81090652
96	Emotional lability (HP:0000712)	1.80199080
97	Sclerocornea (HP:0000647)	1.78885713
98	Hypoplasia of the brainstem (HP:0002365)	1.78132068
99	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.78132068
100	Abnormality of the metopic suture (HP:0005556)	1.77638448

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.94136301
2	MAP2K7	3.68702288
3	CASK	3.41752886
4	MAP3K4	3.32470858
5	EPHA4	3.25751825
6	MAP4K2	3.23308003
7	BCR	2.92136203
8	MARK1	2.57546516
9	TESK1	2.35538343
10	ERBB3	2.32532659
11	LIMK1	2.24022844
12	BCKDK	2.12305540
13	CSNK1G3	2.02672289
14	CSNK1A1L	1.97569203
15	CSNK1G2	1.93895828
16	NEK1	1.85879421
17	VRK2	1.79042220
18	TESK2	1.78139859
19	TSSK6	1.77982549
20	WNK3	1.71076818
21	CSNK1G1	1.70006916
22	SRPK1	1.57434305
23	MAP3K12	1.53486949
24	EIF2AK1	1.50848301
25	SIK3	1.48295764
26	BUB1	1.45788538
27	VRK1	1.42614474
28	MINK1	1.38881820
29	DYRK2	1.36619354
30	DAPK1	1.35164765
31	MAPK13	1.29617510
32	MUSK	1.28139924
33	CDK19	1.27863589
34	EPHA3	1.27630410
35	PAK6	1.20091262
36	DAPK2	1.16223783
37	NUAK1	1.13375128
38	MAP2K4	1.09476236
39	MAPK15	1.08300141
40	PAK3	0.96600687
41	CAMKK2	0.93675480
42	GRK5	0.87427168
43	OXSR1	0.87373288
44	PRKCG	0.81158402
45	UHMK1	0.77247092
46	PLK2	0.76960757
47	PRKCE	0.74068688
48	PIM2	0.73180618
49	CDK14	0.71562386
50	CDK5	0.70207767
51	PHKG1	0.68165019
52	PHKG2	0.68165019
53	GRK7	0.67400188
54	MAP3K6	0.66494370
55	PLK3	0.66299989
56	STK16	0.65111473
57	CDK18	0.63692078
58	MKNK2	0.62798255
59	PINK1	0.62531554
60	GRK1	0.62496522
61	PBK	0.61868764
62	NTRK2	0.61263495
63	CAMK2A	0.59801352
64	FER	0.59244434
65	PRKD3	0.56380821
66	CAMK2B	0.55512873
67	NTRK3	0.55499083
68	CCNB1	0.55002933
69	MAP3K5	0.53669746
70	CDK11A	0.51374210
71	CDK15	0.51242721
72	FGFR2	0.49993921
73	PDK2	0.49356971
74	NME1	0.48994423
75	EIF2AK3	0.48530448
76	PKN1	0.47198233
77	MYLK	0.46965189
78	ADRBK2	0.46658571
79	CSNK1A1	0.45754737
80	DYRK1A	0.44547291
81	BRSK1	0.42487110
82	SIK2	0.42240117
83	NEK6	0.41788117
84	TLK1	0.40617862
85	EPHA2	0.39769079
86	PRKACA	0.37637700
87	MATK	0.34837153
88	RPS6KA5	0.34076370
89	MKNK1	0.33875658
90	AURKA	0.32727649
91	CAMK2G	0.30830638
92	MST1R	0.30512298
93	ADRBK1	0.30391266
94	PLK1	0.29334444
95	AKT2	0.28512511
96	CDK3	0.28209026
97	CSNK2A1	0.28052846
98	STK39	0.27810980
99	PTK2B	0.27687302
100	EGFR	0.27661517

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.69509494
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.35735437
3	Proteasome_Homo sapiens_hsa03050	2.92323768
4	Parkinsons disease_Homo sapiens_hsa05012	2.72341117
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.34642045
6	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.23424885
7	Nicotine addiction_Homo sapiens_hsa05033	2.17178140
8	RNA polymerase_Homo sapiens_hsa03020	2.15804036
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.12841532
10	Steroid biosynthesis_Homo sapiens_hsa00100	1.98861020
11	Vibrio cholerae infection_Homo sapiens_hsa05110	1.98790443
12	Huntingtons disease_Homo sapiens_hsa05016	1.94832731
13	Fatty acid elongation_Homo sapiens_hsa00062	1.91596610
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91556617
15	Alzheimers disease_Homo sapiens_hsa05010	1.87063055
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.85922744
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79194112
18	GABAergic synapse_Homo sapiens_hsa04727	1.75634402
19	Phototransduction_Homo sapiens_hsa04744	1.64031891
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.57098568
21	Sulfur metabolism_Homo sapiens_hsa00920	1.54416634
22	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.53012784
23	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.52198797
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49643286
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.47917437
26	Folate biosynthesis_Homo sapiens_hsa00790	1.47345358
27	Regulation of autophagy_Homo sapiens_hsa04140	1.46444074
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.42837367
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.38528369
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.38371066
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.31364201
32	Basal transcription factors_Homo sapiens_hsa03022	1.29908894
33	Propanoate metabolism_Homo sapiens_hsa00640	1.29503494
34	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.28940450
35	Cocaine addiction_Homo sapiens_hsa05030	1.25450844
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.24368957
37	Butanoate metabolism_Homo sapiens_hsa00650	1.24187337
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22861193
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.21744297
40	Amphetamine addiction_Homo sapiens_hsa05031	1.17094775
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17039304
42	Circadian entrainment_Homo sapiens_hsa04713	1.15673944
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.13850241
44	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.13726201
45	Morphine addiction_Homo sapiens_hsa05032	1.11910679
46	Circadian rhythm_Homo sapiens_hsa04710	1.08559285
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.00687415
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.99531149
49	Spliceosome_Homo sapiens_hsa03040	0.98811638
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97239649
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95343384
52	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.90775352
53	Oocyte meiosis_Homo sapiens_hsa04114	0.87854405
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87469143
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84786685
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.84130550
57	RNA transport_Homo sapiens_hsa03013	0.80162300
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79650280
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79031083
60	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.78713101
61	Insulin secretion_Homo sapiens_hsa04911	0.77492173
62	Taste transduction_Homo sapiens_hsa04742	0.76536024
63	Metabolic pathways_Homo sapiens_hsa01100	0.75572672
64	Base excision repair_Homo sapiens_hsa03410	0.75338238
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75313185
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72766452
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69261838
68	Carbon metabolism_Homo sapiens_hsa01200	0.69049782
69	Sulfur relay system_Homo sapiens_hsa04122	0.66997126
70	Peroxisome_Homo sapiens_hsa04146	0.63676438
71	Purine metabolism_Homo sapiens_hsa00230	0.63361570
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.60917821
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59654545
74	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.58622091
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.56697768
76	Caffeine metabolism_Homo sapiens_hsa00232	0.53923829
77	Olfactory transduction_Homo sapiens_hsa04740	0.53495493
78	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.52829872
79	Alcoholism_Homo sapiens_hsa05034	0.52618710
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.51729487
81	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51386903
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.50800557
83	RNA degradation_Homo sapiens_hsa03018	0.50657775
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.50159178
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.48714877
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.46662722
87	Salivary secretion_Homo sapiens_hsa04970	0.44574320
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.44084555
89	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.42870907
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39890832
91	Long-term depression_Homo sapiens_hsa04730	0.37932841
92	Axon guidance_Homo sapiens_hsa04360	0.36878645
93	Serotonergic synapse_Homo sapiens_hsa04726	0.36715799
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36410337
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33543327
96	Shigellosis_Homo sapiens_hsa05131	0.32302336
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32023082
98	Nitrogen metabolism_Homo sapiens_hsa00910	0.31327624
99	Tight junction_Homo sapiens_hsa04530	0.27478127
100	Cholinergic synapse_Homo sapiens_hsa04725	0.24706074

SYS1-DBNDD2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »