SYT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.54279173
2vocalization behavior (GO:0071625)5.91520618
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.90453682
4synaptic vesicle maturation (GO:0016188)5.83125895
5* synaptic vesicle exocytosis (GO:0016079)5.71411052
6locomotory exploration behavior (GO:0035641)5.54343026
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.46337610
8* glutamate secretion (GO:0014047)5.39580833
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.29395056
10regulation of synaptic vesicle exocytosis (GO:2000300)5.25938713
11protein localization to synapse (GO:0035418)5.24354356
12regulation of glutamate receptor signaling pathway (GO:1900449)5.12656543
13neuron cell-cell adhesion (GO:0007158)5.00325571
14* positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98383226
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.80370632
16neuronal action potential propagation (GO:0019227)4.71665130
17regulation of synaptic vesicle transport (GO:1902803)4.71262378
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.71245791
19* neurotransmitter secretion (GO:0007269)4.59872512
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.56609994
21L-amino acid import (GO:0043092)4.54906873
22exploration behavior (GO:0035640)4.52776229
23cerebellar granule cell differentiation (GO:0021707)4.50003452
24regulation of neuronal synaptic plasticity (GO:0048168)4.47099692
25glutamate receptor signaling pathway (GO:0007215)4.38608315
26synaptic transmission, glutamatergic (GO:0035249)4.35610068
27neurotransmitter-gated ion channel clustering (GO:0072578)4.28931276
28neuron-neuron synaptic transmission (GO:0007270)4.28800777
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.21218252
30amino acid import (GO:0043090)4.20788651
31neuronal ion channel clustering (GO:0045161)4.16731112
32positive regulation of synapse maturation (GO:0090129)4.09509324
33regulation of synapse structural plasticity (GO:0051823)4.07548227
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.06733826
35layer formation in cerebral cortex (GO:0021819)4.03758603
36long-term memory (GO:0007616)3.98735560
37positive regulation of membrane potential (GO:0045838)3.97870069
38gamma-aminobutyric acid transport (GO:0015812)3.97714715
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95825328
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.95358186
41cellular potassium ion homeostasis (GO:0030007)3.95086758
42regulation of postsynaptic membrane potential (GO:0060078)3.90793004
43proline transport (GO:0015824)3.88480019
44potassium ion homeostasis (GO:0055075)3.80725893
45* neurotransmitter transport (GO:0006836)3.80028825
46synaptic vesicle endocytosis (GO:0048488)3.78374453
47dendritic spine morphogenesis (GO:0060997)3.77532842
48central nervous system myelination (GO:0022010)3.75216006
49axon ensheathment in central nervous system (GO:0032291)3.75216006
50long-term synaptic potentiation (GO:0060291)3.74300728
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73354096
52regulation of synaptic plasticity (GO:0048167)3.72180843
53neuron recognition (GO:0008038)3.68283045
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66229072
55regulation of neurotransmitter secretion (GO:0046928)3.65854433
56cell communication by electrical coupling (GO:0010644)3.56593189
57potassium ion import (GO:0010107)3.56531422
58response to histamine (GO:0034776)3.56027662
59positive regulation of neurotransmitter secretion (GO:0001956)3.53821464
60positive regulation of neurotransmitter transport (GO:0051590)3.53325833
61regulation of dendritic spine morphogenesis (GO:0061001)3.52653402
62* regulation of neurotransmitter levels (GO:0001505)3.51311327
63acidic amino acid transport (GO:0015800)3.47318896
64negative regulation of dendrite morphogenesis (GO:0050774)3.47265715
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43583306
66cellular sodium ion homeostasis (GO:0006883)3.41989703
67cerebellar Purkinje cell differentiation (GO:0021702)3.41149737
68regulation of neurotransmitter transport (GO:0051588)3.39973299
69establishment of mitochondrion localization (GO:0051654)3.39951352
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.39468268
71activation of protein kinase A activity (GO:0034199)3.39251330
72behavioral response to cocaine (GO:0048148)3.37689768
73presynaptic membrane assembly (GO:0097105)3.37453322
74sodium ion export (GO:0071436)3.36983905
75postsynaptic membrane organization (GO:0001941)3.35595961
76* regulation of synaptic transmission, glutamatergic (GO:0051966)3.34106063
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.33513180
78neurotransmitter uptake (GO:0001504)3.32998367
79transmission of nerve impulse (GO:0019226)3.32123813
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31362228
81neuromuscular synaptic transmission (GO:0007274)3.30971172
82membrane depolarization (GO:0051899)3.30728991
83axonal fasciculation (GO:0007413)3.29730736
84membrane hyperpolarization (GO:0060081)3.28916534
85* regulation of vesicle fusion (GO:0031338)3.28564643
86cell migration in hindbrain (GO:0021535)3.27597406
87mating behavior (GO:0007617)3.22539759
88learning (GO:0007612)3.19416557
89regulation of synapse maturation (GO:0090128)3.18797384
90* establishment of synaptic vesicle localization (GO:0097480)3.17660003
91* synaptic vesicle transport (GO:0048489)3.17660003
92synapse assembly (GO:0007416)3.17481323
93innervation (GO:0060384)3.16965133
94intraspecies interaction between organisms (GO:0051703)3.15610039
95social behavior (GO:0035176)3.15610039
96behavioral defense response (GO:0002209)3.15131367
97behavioral fear response (GO:0001662)3.15131367
98regulation of voltage-gated calcium channel activity (GO:1901385)3.14638175
99positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14095086
100* synaptic transmission (GO:0007268)3.13886950
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13347361
102membrane depolarization during action potential (GO:0086010)3.13146841
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12210427
104neuromuscular process controlling posture (GO:0050884)3.11736781
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11054084
106presynaptic membrane organization (GO:0097090)3.10323426
107neuromuscular process controlling balance (GO:0050885)3.10169184
108regulation of dendritic spine development (GO:0060998)3.09578177
109adult walking behavior (GO:0007628)3.08687694
110auditory behavior (GO:0031223)3.07666667
111prepulse inhibition (GO:0060134)3.06697127
112* regulation of synaptic transmission (GO:0050804)3.06523503
113fear response (GO:0042596)3.05738976
114response to auditory stimulus (GO:0010996)3.05597590
115L-glutamate transport (GO:0015813)3.04934337
116* positive regulation of synaptic transmission (GO:0050806)3.03537562
117cell communication involved in cardiac conduction (GO:0086065)3.01331808
118cell differentiation in hindbrain (GO:0021533)2.99705614
119positive regulation of dendritic spine development (GO:0060999)2.97943685
120startle response (GO:0001964)2.96289863
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96241884
122vesicle transport along microtubule (GO:0047496)2.95784703
123long term synaptic depression (GO:0060292)2.95690069
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.92614627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.28649725
2GBX2_23144817_ChIP-Seq_PC3_Human3.87104360
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23180747
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12374275
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10257229
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.80058637
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70534354
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70534354
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67993825
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64031135
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.58225975
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55842120
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53521915
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52047739
15DROSHA_22980978_ChIP-Seq_HELA_Human2.49637385
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47288380
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.46375325
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.26941358
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.26868062
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22797747
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.18167342
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.13868481
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12285700
24TAF15_26573619_Chip-Seq_HEK293_Human2.11451286
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03422867
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99559954
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97276814
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97081399
29AR_21572438_ChIP-Seq_LNCaP_Human1.87726284
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87400040
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82082125
32* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.78708115
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.74874327
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74002314
35* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73032836
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62043536
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59006212
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.52815937
39* P300_19829295_ChIP-Seq_ESCs_Human1.48762949
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48693581
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44751963
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40033242
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.39727532
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36497844
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36374285
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.36341296
47ZNF274_21170338_ChIP-Seq_K562_Hela1.35920353
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35907636
49* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34299340
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31358634
51* AR_25329375_ChIP-Seq_VCAP_Human1.31321698
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27198733
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.27055788
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26286798
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.26263421
56IGF1R_20145208_ChIP-Seq_DFB_Human1.25575379
57STAT3_23295773_ChIP-Seq_U87_Human1.25379403
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24738783
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24151222
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23765570
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.22881930
62* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22722414
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21001430
64* AR_19668381_ChIP-Seq_PC3_Human1.19756943
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18809874
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14813527
67* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14368968
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13773293
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13470928
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13151778
71TCF4_23295773_ChIP-Seq_U87_Human1.12552956
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10113193
73* FUS_26573619_Chip-Seq_HEK293_Human1.08606926
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07704640
75RNF2_27304074_Chip-Seq_NSC_Mouse1.07051026
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07037348
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.05868696
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.04940650
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.04716654
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04667418
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04560743
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04029226
83KDM2B_26808549_Chip-Seq_K562_Human1.03752475
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03735332
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03710616
86* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02620923
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00875922
88* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00707530
89* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00363425
90RUNX2_22187159_ChIP-Seq_PCA_Human1.00078194
91AHR_22903824_ChIP-Seq_MCF-7_Human0.99758529
92VDR_22108803_ChIP-Seq_LS180_Human0.99358011
93TP53_16413492_ChIP-PET_HCT116_Human0.98472815
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95945849
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95626393
96BCAT_22108803_ChIP-Seq_LS180_Human0.94962145
97ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94125578
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.93704471
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93663025
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.92971618
101SOX9_26525672_Chip-Seq_HEART_Mouse0.92647711
102* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92356501
103* JUN_21703547_ChIP-Seq_K562_Human0.92118426
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90765667
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90765667
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90680371
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90363568
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89555038
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89514150
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.88999858
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.88722503
112* ER_23166858_ChIP-Seq_MCF-7_Human0.87565555
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86639844
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86410009
115TP53_18474530_ChIP-ChIP_U2OS_Human0.86287307
116CTCF_27219007_Chip-Seq_Bcells_Human0.85951659
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81958549
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81892092
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81841574
120* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80157697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.61669899
2MP0003880_abnormal_central_pattern5.13593014
3* MP0003635_abnormal_synaptic_transmissio4.27077257
4MP0004270_analgesia3.64205359
5MP0009745_abnormal_behavioral_response3.59381958
6MP0002063_abnormal_learning/memory/cond3.42944981
7MP0002064_seizures3.36510981
8MP0009046_muscle_twitch3.29713197
9MP0002822_catalepsy3.18812912
10MP0001968_abnormal_touch/_nociception3.07316829
11MP0002572_abnormal_emotion/affect_behav2.93191601
12MP0002272_abnormal_nervous_system2.68443468
13MP0005423_abnormal_somatic_nervous2.67653660
14MP0002734_abnormal_mechanical_nocicepti2.64272215
15MP0001486_abnormal_startle_reflex2.60312799
16MP0001501_abnormal_sleep_pattern2.55445201
17MP0002736_abnormal_nociception_after2.37703722
18MP0002735_abnormal_chemical_nociception2.18660150
19MP0001440_abnormal_grooming_behavior2.16210540
20MP0002067_abnormal_sensory_capabilities2.01338881
21MP0002733_abnormal_thermal_nociception2.00520897
22MP0001970_abnormal_pain_threshold1.94925242
23MP0008569_lethality_at_weaning1.83008895
24MP0005386_behavior/neurological_phenoty1.82629043
25MP0004924_abnormal_behavior1.82629043
26MP0009780_abnormal_chondrocyte_physiolo1.81724483
27MP0003329_amyloid_beta_deposits1.81079016
28MP0002184_abnormal_innervation1.78375265
29MP0006276_abnormal_autonomic_nervous1.77016702
30MP0003879_abnormal_hair_cell1.75331260
31MP0002557_abnormal_social/conspecific_i1.75125997
32MP0004811_abnormal_neuron_physiology1.70302061
33MP0001984_abnormal_olfaction1.69961121
34MP0002909_abnormal_adrenal_gland1.68221063
35MP0000778_abnormal_nervous_system1.61525338
36MP0005646_abnormal_pituitary_gland1.61191939
37MP0004858_abnormal_nervous_system1.59569745
38MP0001905_abnormal_dopamine_level1.57009084
39MP0001529_abnormal_vocalization1.55053591
40MP0005551_abnormal_eye_electrophysiolog1.43890525
41MP0000955_abnormal_spinal_cord1.42481559
42MP0002066_abnormal_motor_capabilities/c1.41420426
43MP0002882_abnormal_neuron_morphology1.40698227
44MP0003123_paternal_imprinting1.40054531
45MP0003787_abnormal_imprinting1.40021749
46MP0001502_abnormal_circadian_rhythm1.33812667
47MP0003633_abnormal_nervous_system1.30391066
48MP0001188_hyperpigmentation1.27501396
49MP0008872_abnormal_physiological_respon1.23360766
50MP0005645_abnormal_hypothalamus_physiol1.19228975
51MP0010386_abnormal_urinary_bladder1.16948263
52MP0003122_maternal_imprinting1.16748557
53MP0004885_abnormal_endolymph1.15905192
54MP0004142_abnormal_muscle_tone1.15071467
55MP0003631_nervous_system_phenotype1.12486268
56MP0004147_increased_porphyrin_level1.09124702
57MP0008877_abnormal_DNA_methylation1.08058857
58MP0002152_abnormal_brain_morphology1.04498487
59MP0002229_neurodegeneration1.02977289
60MP0003121_genomic_imprinting1.00254817
61MP0000751_myopathy0.99915980
62MP0002837_dystrophic_cardiac_calcinosis0.99435539
63MP0008874_decreased_physiological_sensi0.97470423
64MP0002090_abnormal_vision0.96773827
65MP0001986_abnormal_taste_sensitivity0.96384897
66MP0005535_abnormal_body_temperature0.93831242
67* MP0002069_abnormal_eating/drinking_beha0.90945705
68MP0004145_abnormal_muscle_electrophysio0.90901824
69MP0000569_abnormal_digit_pigmentation0.89024146
70MP0001177_atelectasis0.86560945
71MP0000013_abnormal_adipose_tissue0.85633144
72MP0005499_abnormal_olfactory_system0.84300611
73MP0005394_taste/olfaction_phenotype0.84300611
74MP0004085_abnormal_heartbeat0.83325057
75MP0004742_abnormal_vestibular_system0.82397425
76MP0002638_abnormal_pupillary_reflex0.81721396
77MP0001963_abnormal_hearing_physiology0.81703226
78MP0004215_abnormal_myocardial_fiber0.80405346
79MP0000604_amyloidosis0.80375975
80MP0003632_abnormal_nervous_system0.77702555
81MP0002752_abnormal_somatic_nervous0.77438846
82MP0003075_altered_response_to0.74108050
83MP0002876_abnormal_thyroid_physiology0.73768894
84MP0001664_abnormal_digestion0.72910979
85MP0004484_altered_response_of0.71875736
86MP0000631_abnormal_neuroendocrine_gland0.70656355
87MP0004233_abnormal_muscle_weight0.69213626
88MP0003634_abnormal_glial_cell0.68648351
89MP0001348_abnormal_lacrimal_gland0.65537483
90MP0003861_abnormal_nervous_system0.65397575
91MP0008961_abnormal_basal_metabolism0.64425035
92MP0004510_myositis0.63879121
93MP0001346_abnormal_lacrimal_gland0.63319895
94MP0005409_darkened_coat_color0.62879492
95MP0006072_abnormal_retinal_apoptosis0.62385436
96MP0005623_abnormal_meninges_morphology0.60914277
97MP0005253_abnormal_eye_physiology0.59434222
98MP0005187_abnormal_penis_morphology0.59344568
99MP0003690_abnormal_glial_cell0.59133290
100MP0000026_abnormal_inner_ear0.57489885
101MP0001299_abnormal_eye_distance/0.55781327
102MP0000920_abnormal_myelination0.55736005
103MP0001943_abnormal_respiration0.53784044
104MP0010234_abnormal_vibrissa_follicle0.53513080
105MP0003137_abnormal_impulse_conducting0.52063634
106MP0003938_abnormal_ear_development0.50129779
107MP0003956_abnormal_body_size0.49740401
108* MP0010769_abnormal_survival0.49718477
109MP0003283_abnormal_digestive_organ0.48938782
110* MP0010770_preweaning_lethality0.48671125
111* MP0002082_postnatal_lethality0.48671125
112MP0001485_abnormal_pinna_reflex0.48020321
113MP0005167_abnormal_blood-brain_barrier0.47349922
114* MP0010768_mortality/aging0.46622160
115MP0004043_abnormal_pH_regulation0.44901612
116MP0000639_abnormal_adrenal_gland0.43171526
117MP0000579_abnormal_nail_morphology0.42841898

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.58417653
2Myokymia (HP:0002411)6.66949935
3Focal seizures (HP:0007359)6.20556645
4Visual hallucinations (HP:0002367)5.61546019
5Epileptic encephalopathy (HP:0200134)5.56204851
6Atonic seizures (HP:0010819)5.25889722
7Febrile seizures (HP:0002373)5.00886224
8Absence seizures (HP:0002121)4.73902387
9Progressive cerebellar ataxia (HP:0002073)4.47091328
10Dialeptic seizures (HP:0011146)4.31166477
11Generalized tonic-clonic seizures (HP:0002069)4.25609376
12Hyperventilation (HP:0002883)3.98547551
13Broad-based gait (HP:0002136)3.76420420
14Gaze-evoked nystagmus (HP:0000640)3.56508642
15Poor eye contact (HP:0000817)3.54469474
16Action tremor (HP:0002345)3.53881130
17Impaired vibration sensation in the lower limbs (HP:0002166)3.30778488
18Dysdiadochokinesis (HP:0002075)3.27791578
19Cerebral hypomyelination (HP:0006808)3.26491438
20Amblyopia (HP:0000646)3.26180731
21Depression (HP:0000716)3.24956922
22Impaired social interactions (HP:0000735)3.24581770
23Abnormal social behavior (HP:0012433)3.24581770
24Supranuclear gaze palsy (HP:0000605)3.23391123
25Truncal ataxia (HP:0002078)3.10014364
26Ankle clonus (HP:0011448)3.06988989
27Dysmetria (HP:0001310)3.05557961
28Anxiety (HP:0000739)3.00763514
29Urinary bladder sphincter dysfunction (HP:0002839)3.00364338
30Postural instability (HP:0002172)2.92546671
31Mutism (HP:0002300)2.89350043
32Limb dystonia (HP:0002451)2.88120405
33Abnormal eating behavior (HP:0100738)2.87003550
34Progressive inability to walk (HP:0002505)2.82000676
35Drooling (HP:0002307)2.80250579
36Excessive salivation (HP:0003781)2.80250579
37Papilledema (HP:0001085)2.80176092
38Akinesia (HP:0002304)2.77243494
39Tetraplegia (HP:0002445)2.76869871
40Epileptiform EEG discharges (HP:0011182)2.74034740
41Impaired smooth pursuit (HP:0007772)2.66651809
42Genetic anticipation (HP:0003743)2.65384785
43Cerebral inclusion bodies (HP:0100314)2.65369877
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.63984923
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.63984923
46Bradykinesia (HP:0002067)2.62180916
47Absent speech (HP:0001344)2.58976850
48EEG with generalized epileptiform discharges (HP:0011198)2.57803714
49Abnormality of binocular vision (HP:0011514)2.55661877
50Diplopia (HP:0000651)2.55661877
51Abnormality of the lower motor neuron (HP:0002366)2.55341894
52Inability to walk (HP:0002540)2.53800818
53Clonus (HP:0002169)2.52040344
54Hemiparesis (HP:0001269)2.51753140
55Status epilepticus (HP:0002133)2.50968271
56Urinary urgency (HP:0000012)2.50393950
57Pheochromocytoma (HP:0002666)2.47174840
58Scanning speech (HP:0002168)2.46822405
59Torticollis (HP:0000473)2.46649223
60Obstructive sleep apnea (HP:0002870)2.45593862
61Sleep apnea (HP:0010535)2.44964244
62Morphological abnormality of the pyramidal tract (HP:0002062)2.40843960
63Neurofibrillary tangles (HP:0002185)2.40814076
64Peripheral hypomyelination (HP:0007182)2.39850403
65Stereotypic behavior (HP:0000733)2.39698741
66Dysmetric saccades (HP:0000641)2.39451064
67Focal dystonia (HP:0004373)2.38670557
68Spastic gait (HP:0002064)2.38259453
69Abnormality of ocular smooth pursuit (HP:0000617)2.36770654
70Hypsarrhythmia (HP:0002521)2.36434573
71Generalized myoclonic seizures (HP:0002123)2.33490672
72Fetal akinesia sequence (HP:0001989)2.33249356
73Apathy (HP:0000741)2.33032682
74Hemiplegia (HP:0002301)2.32839997
75Impaired vibratory sensation (HP:0002495)2.28309778
76Termporal pattern (HP:0011008)2.25375453
77Insidious onset (HP:0003587)2.25375453
78Polyphagia (HP:0002591)2.23299892
79CNS hypomyelination (HP:0003429)2.22835184
80Intention tremor (HP:0002080)2.19603149
81Spastic tetraplegia (HP:0002510)2.17244472
82Neuroendocrine neoplasm (HP:0100634)2.16726325
83Spastic tetraparesis (HP:0001285)2.13212343
84Central scotoma (HP:0000603)2.09847805
85Diminished motivation (HP:0000745)2.09218168
86Delusions (HP:0000746)2.08575281
87Choreoathetosis (HP:0001266)2.07991453
88Craniofacial dystonia (HP:0012179)2.07944840
89Gait ataxia (HP:0002066)2.04370041
90Ventricular fibrillation (HP:0001663)2.04081864
91Blue irides (HP:0000635)2.03845492
92Insomnia (HP:0100785)2.03018573
93Protruding tongue (HP:0010808)2.02197894
94Lower limb muscle weakness (HP:0007340)2.00128559
95Abnormality of the corticospinal tract (HP:0002492)1.99988327
96Incomplete penetrance (HP:0003829)1.98660226
97Gait imbalance (HP:0002141)1.98500699
98Abnormality of macular pigmentation (HP:0008002)1.91818610
99Hypoventilation (HP:0002791)1.91628980
100Split foot (HP:0001839)1.90264250
101Abnormality of salivation (HP:0100755)1.89467808
102Rigidity (HP:0002063)1.88629796
103Agitation (HP:0000713)1.88436478
104Annular pancreas (HP:0001734)1.85326384
105Megalencephaly (HP:0001355)1.85115599
106Psychosis (HP:0000709)1.82199059
107Specific learning disability (HP:0001328)1.82191027
108Resting tremor (HP:0002322)1.81696316
109Neuronal loss in central nervous system (HP:0002529)1.79004260
110Inappropriate behavior (HP:0000719)1.77983122
111Paraplegia (HP:0010550)1.77916999
112Failure to thrive in infancy (HP:0001531)1.77059633
113Congenital stationary night blindness (HP:0007642)1.74966507
114Rapidly progressive (HP:0003678)1.73130001
115Hypoplasia of the corpus callosum (HP:0002079)1.72790300
116Amyotrophic lateral sclerosis (HP:0007354)1.71650957
117Spastic paraplegia (HP:0001258)1.69366340
118Hyperthyroidism (HP:0000836)1.69307488
119Unsteady gait (HP:0002317)1.67619924
120Muscular hypotonia of the trunk (HP:0008936)1.65962170
121Abnormality of saccadic eye movements (HP:0000570)1.65822670
122Generalized hypopigmentation of hair (HP:0011358)1.65755072
123Neoplasm of the peripheral nervous system (HP:0100007)1.65728324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.47841460
2NTRK34.40564684
3MAP3K93.84023172
4MAP3K43.25167698
5MAP2K72.81751074
6DAPK22.79195926
7MINK12.56338474
8MARK12.53933319
9MAP3K122.43799615
10CASK2.32936836
11RIPK42.28229024
12PAK62.22554729
13MAP2K42.09795618
14KSR22.06034345
15DAPK11.87299438
16NTRK11.86894831
17NTRK21.85872623
18PNCK1.81441212
19PLK21.76087569
20CAMKK11.70274340
21GRK51.68638007
22PRKD31.64133616
23CDK191.62876462
24KSR11.57765982
25ARAF1.56445507
26CDK51.52534963
27TNIK1.38623859
28SIK21.34870914
29MAP3K131.32319448
30PRPF4B1.29986285
31STK381.26805604
32PRKCG1.24474414
33FES1.22842781
34MAPK131.16621644
35CAMKK21.14258968
36CAMK2A1.08655723
37MAP3K21.01562518
38PTK2B0.97487318
39CAMK10.97091585
40BMPR20.97035868
41CCNB10.94085634
42CDK180.93060965
43UHMK10.91553329
44CDK150.90953271
45TYRO30.90181840
46RAF10.90122216
47CDK140.87904548
48CAMK2B0.86325204
49OXSR10.85276206
50SGK2230.82160387
51SGK4940.82160387
52NME10.81841449
53LATS20.81328008
54STK110.81194325
55CDK11A0.79185483
56TAOK10.76956687
57RET0.76675670
58CSNK1G20.75756981
59PINK10.73766042
60DYRK1A0.72733656
61PKN10.71594254
62SGK20.71107757
63PRKCH0.68431211
64SGK10.68164622
65PHKG10.67937197
66PHKG20.67937197
67LIMK10.66379168
68PAK30.65206650
69DYRK20.62138979
70PDK10.61940560
71RIPK10.60122819
72MAP3K10.59340948
73CAMK1G0.58161241
74BCR0.56429849
75FGR0.55353037
76CAMK2D0.55308025
77SGK30.55280450
78AKT30.55024997
79TNK20.54254448
80PRKCE0.54168333
81PDPK10.53944710
82CSNK1G30.52348992
83MAP3K60.51206022
84ALK0.49419415
85MAP3K110.49211637
86MAPKAPK50.47288585
87MARK20.47243912
88CAMK2G0.46890159
89DAPK30.46308064
90PRKCZ0.46152194
91BRSK10.46075116
92NEK10.45897714
93FER0.45852081
94MAP2K10.45738901
95RPS6KA30.45193675
96MAP3K70.44348028
97CSNK1A1L0.43959156
98BRAF0.41961145
99CAMK40.40798749
100FYN0.39785960
101MAPK100.37906940
102CSNK1E0.37416699
103WNK10.36036503
104PRKCA0.35186799
105FGFR20.34900416
106LMTK20.34691575
107MAPK120.34218177
108CSNK1D0.33503064
109PRKG10.33195569
110PRKACA0.32817116
111PRKCB0.32060423
112TESK10.31842324
113CSNK1G10.31767961
114SIK30.30907758
115WNK30.30667312
116ROCK20.30502331
117NEK60.30389035
118CDC42BPA0.30279955
119CSNK1A10.29478334
120TRIM280.29060012

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97058777
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.58707265
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84138435
4GABAergic synapse_Homo sapiens_hsa047272.81664417
5Olfactory transduction_Homo sapiens_hsa047402.74544358
6Circadian entrainment_Homo sapiens_hsa047132.72599788
7Long-term potentiation_Homo sapiens_hsa047202.70515029
8Amphetamine addiction_Homo sapiens_hsa050312.59943478
9Glutamatergic synapse_Homo sapiens_hsa047242.59041576
10Morphine addiction_Homo sapiens_hsa050322.57724321
11Dopaminergic synapse_Homo sapiens_hsa047282.25378705
12Salivary secretion_Homo sapiens_hsa049702.24490699
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20996593
14Insulin secretion_Homo sapiens_hsa049112.04442964
15Cholinergic synapse_Homo sapiens_hsa047251.94423848
16Collecting duct acid secretion_Homo sapiens_hsa049661.93433021
17Gastric acid secretion_Homo sapiens_hsa049711.85888722
18Taste transduction_Homo sapiens_hsa047421.82169009
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80908367
20Serotonergic synapse_Homo sapiens_hsa047261.78695668
21Renin secretion_Homo sapiens_hsa049241.74070606
22Long-term depression_Homo sapiens_hsa047301.71068125
23Cocaine addiction_Homo sapiens_hsa050301.69082789
24Oxytocin signaling pathway_Homo sapiens_hsa049211.67914568
25Calcium signaling pathway_Homo sapiens_hsa040201.64005383
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61925758
27Phototransduction_Homo sapiens_hsa047441.44630933
28GnRH signaling pathway_Homo sapiens_hsa049121.41004109
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31585575
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30481111
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29197478
32Gap junction_Homo sapiens_hsa045401.28934569
33cAMP signaling pathway_Homo sapiens_hsa040241.21085342
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17772616
35Vibrio cholerae infection_Homo sapiens_hsa051101.15827170
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15261268
37Vitamin B6 metabolism_Homo sapiens_hsa007501.11967065
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11262400
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10466527
40Estrogen signaling pathway_Homo sapiens_hsa049151.08677738
41Cardiac muscle contraction_Homo sapiens_hsa042601.08283948
42Type II diabetes mellitus_Homo sapiens_hsa049301.07574610
43Glioma_Homo sapiens_hsa052141.04020213
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02666917
45Melanogenesis_Homo sapiens_hsa049160.96086562
46ErbB signaling pathway_Homo sapiens_hsa040120.94781585
47Axon guidance_Homo sapiens_hsa043600.94488581
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90515479
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90028089
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84867574
51Pancreatic secretion_Homo sapiens_hsa049720.84045608
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82985719
53Oocyte meiosis_Homo sapiens_hsa041140.80848110
54Thyroid hormone synthesis_Homo sapiens_hsa049180.73863171
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.72729371
56Dorso-ventral axis formation_Homo sapiens_hsa043200.71960847
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68267043
58Dilated cardiomyopathy_Homo sapiens_hsa054140.67940674
59MAPK signaling pathway_Homo sapiens_hsa040100.65691345
60Choline metabolism in cancer_Homo sapiens_hsa052310.63513302
61Nitrogen metabolism_Homo sapiens_hsa009100.61117155
62Type I diabetes mellitus_Homo sapiens_hsa049400.60145110
63Glucagon signaling pathway_Homo sapiens_hsa049220.58268820
64Alzheimers disease_Homo sapiens_hsa050100.57995062
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57352820
66VEGF signaling pathway_Homo sapiens_hsa043700.56336443
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53613638
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53528933
69Alcoholism_Homo sapiens_hsa050340.51445829
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51007532
71African trypanosomiasis_Homo sapiens_hsa051430.50883832
72Ras signaling pathway_Homo sapiens_hsa040140.50871799
73Circadian rhythm_Homo sapiens_hsa047100.50690222
74Inositol phosphate metabolism_Homo sapiens_hsa005620.49804721
75Oxidative phosphorylation_Homo sapiens_hsa001900.49152655
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.48705499
77Rap1 signaling pathway_Homo sapiens_hsa040150.46803505
78Bile secretion_Homo sapiens_hsa049760.43939224
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.43853804
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42489795
81mTOR signaling pathway_Homo sapiens_hsa041500.42451981
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42101612
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41424613
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37035080
85Endocytosis_Homo sapiens_hsa041440.36165375
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35461796
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34407898
88Wnt signaling pathway_Homo sapiens_hsa043100.33695466
89Rheumatoid arthritis_Homo sapiens_hsa053230.33629057
90Fatty acid biosynthesis_Homo sapiens_hsa000610.33023117
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32914185
92Prion diseases_Homo sapiens_hsa050200.31940869
93Parkinsons disease_Homo sapiens_hsa050120.31348215
94Non-small cell lung cancer_Homo sapiens_hsa052230.31296397
95Arginine and proline metabolism_Homo sapiens_hsa003300.30400944
96Insulin signaling pathway_Homo sapiens_hsa049100.30009612
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29115755
98Renal cell carcinoma_Homo sapiens_hsa052110.28366860
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27649109
100Regulation of autophagy_Homo sapiens_hsa041400.27107426
101Ovarian steroidogenesis_Homo sapiens_hsa049130.26864155
102Arginine biosynthesis_Homo sapiens_hsa002200.26498899
103Endometrial cancer_Homo sapiens_hsa052130.26301801
104Hippo signaling pathway_Homo sapiens_hsa043900.25983362
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25761999
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25590531
107AMPK signaling pathway_Homo sapiens_hsa041520.23049755
108beta-Alanine metabolism_Homo sapiens_hsa004100.22869531
109Tight junction_Homo sapiens_hsa045300.22661936
110Mineral absorption_Homo sapiens_hsa049780.22498396
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21673767
112Histidine metabolism_Homo sapiens_hsa003400.21534958
113Butanoate metabolism_Homo sapiens_hsa006500.19276708

Most similar genes based on co-expression Upload to Enrichr

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