SYT10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)6.01513653
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99830147
3ventricular system development (GO:0021591)4.80307877
4protein localization to synapse (GO:0035418)4.66515655
5vocalization behavior (GO:0071625)4.62693773
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59109406
7neuron cell-cell adhesion (GO:0007158)4.57877211
8axonemal dynein complex assembly (GO:0070286)4.55042033
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.51828257
10axoneme assembly (GO:0035082)4.51562195
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.49520627
12regulation of glutamate receptor signaling pathway (GO:1900449)4.49130816
13neurotransmitter-gated ion channel clustering (GO:0072578)4.40878001
14synaptic vesicle maturation (GO:0016188)4.40341505
15cilium or flagellum-dependent cell motility (GO:0001539)4.39378140
16locomotory exploration behavior (GO:0035641)4.33722206
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.29975116
18regulation of centriole replication (GO:0046599)4.26816135
19glutamate receptor signaling pathway (GO:0007215)4.26726191
20glutamate secretion (GO:0014047)4.23990219
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.21363673
22phenol-containing compound catabolic process (GO:0019336)4.21120296
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.18809261
24DNA strand elongation involved in DNA replication (GO:0006271)4.18727178
25synaptic vesicle exocytosis (GO:0016079)4.14513861
26presynaptic membrane assembly (GO:0097105)4.06235922
27kidney morphogenesis (GO:0060993)4.02993645
28Sertoli cell development (GO:0060009)4.00238803
29female mating behavior (GO:0060180)3.94080078
30DNA strand elongation (GO:0022616)3.93974020
31epithelial cilium movement (GO:0003351)3.93485855
32replication fork processing (GO:0031297)3.86246236
33telomere maintenance via semi-conservative replication (GO:0032201)3.84423754
34left/right axis specification (GO:0070986)3.79631002
35chromatin remodeling at centromere (GO:0031055)3.77593755
36DNA replication checkpoint (GO:0000076)3.77379342
37regulation of synaptic vesicle exocytosis (GO:2000300)3.74418688
38regulation of glutamate secretion (GO:0014048)3.70051380
39regulation of neuronal synaptic plasticity (GO:0048168)3.66402087
40synaptic transmission, glutamatergic (GO:0035249)3.66138075
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65352909
42presynaptic membrane organization (GO:0097090)3.64854625
43long-term memory (GO:0007616)3.58123147
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58038210
45neuron-neuron synaptic transmission (GO:0007270)3.57616565
46ribosomal small subunit assembly (GO:0000028)3.57454757
47CENP-A containing nucleosome assembly (GO:0034080)3.55778940
48postsynaptic membrane organization (GO:0001941)3.54765420
49neurotransmitter secretion (GO:0007269)3.53809425
50regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.53382744
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51589933
52long-term synaptic potentiation (GO:0060291)3.51273923
53proline transport (GO:0015824)3.51245913
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.50325528
55neuronal action potential propagation (GO:0019227)3.48538321
56hormone catabolic process (GO:0042447)3.44419977
57regulation of female receptivity (GO:0045924)3.43568768
58gamma-aminobutyric acid transport (GO:0015812)3.43303318
59response to histamine (GO:0034776)3.42887292
60thyroid hormone generation (GO:0006590)3.41534484
61resolution of meiotic recombination intermediates (GO:0000712)3.40594527
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.40505850
63regulation of synaptic vesicle transport (GO:1902803)3.40472032
64transmission of nerve impulse (GO:0019226)3.40136227
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.37325767
66centriole replication (GO:0007099)3.36861079
67exploration behavior (GO:0035640)3.36645229
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30389276
69behavioral defense response (GO:0002209)3.29511796
70behavioral fear response (GO:0001662)3.29511796
71cerebellar Purkinje cell differentiation (GO:0021702)3.28294285
72synaptic vesicle docking involved in exocytosis (GO:0016081)3.27915501
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26155467
74cellular potassium ion homeostasis (GO:0030007)3.25975557
75positive regulation of membrane potential (GO:0045838)3.22997508
76DNA replication initiation (GO:0006270)3.22674122
77negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22148774
78translesion synthesis (GO:0019985)3.21543823
79telomere maintenance via recombination (GO:0000722)3.20926281
80neuron recognition (GO:0008038)3.20389645
81layer formation in cerebral cortex (GO:0021819)3.20218858
82translational termination (GO:0006415)3.19871917
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17126213
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16215420
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16059249
86regulation of non-canonical Wnt signaling pathway (GO:2000050)3.14593403
87regulation of postsynaptic membrane potential (GO:0060078)3.13595742
88histone exchange (GO:0043486)3.11977821
89neurotransmitter transport (GO:0006836)3.11910800
90detection of calcium ion (GO:0005513)3.11675052
91mitotic recombination (GO:0006312)3.11054891
92negative regulation of amino acid transport (GO:0051956)3.10763337
93viral transcription (GO:0019083)3.09032110
94DNA replication-independent nucleosome assembly (GO:0006336)3.04579275
95DNA replication-independent nucleosome organization (GO:0034724)3.04579275
96regulation of synaptic plasticity (GO:0048167)3.04558265
97startle response (GO:0001964)3.04259984
98thyroid hormone metabolic process (GO:0042403)3.04112173
99fear response (GO:0042596)3.03132345
100cerebellar granule cell differentiation (GO:0021707)2.99054307
101dendritic spine morphogenesis (GO:0060997)2.94932140
102nonmotile primary cilium assembly (GO:0035058)2.90675290
103postreplication repair (GO:0006301)2.89689123
104axonal fasciculation (GO:0007413)2.85292846
105neuronal stem cell maintenance (GO:0097150)2.85232024
106membrane depolarization (GO:0051899)2.85132604
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85056203
108dendrite morphogenesis (GO:0048813)2.84360235
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83715020
110regulation of neurotransmitter secretion (GO:0046928)2.83394910
111membrane depolarization during action potential (GO:0086010)2.83032067
112behavioral response to cocaine (GO:0048148)2.82412656
113positive regulation of synapse assembly (GO:0051965)2.81978986
114regulation of protein kinase A signaling (GO:0010738)2.80961975
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80328033
116negative regulation of astrocyte differentiation (GO:0048712)2.80172431
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79934230
118activation of protein kinase A activity (GO:0034199)2.79758470
119regulation of neurotransmitter levels (GO:0001505)2.79034513
120cochlea development (GO:0090102)2.78314379
121spermatid nucleus differentiation (GO:0007289)2.77339679
122regulation of vesicle fusion (GO:0031338)2.77338311
123glycine transport (GO:0015816)2.76792537
124DNA double-strand break processing (GO:0000729)2.75627023
125learning (GO:0007612)2.75505032
126telomere maintenance via telomere lengthening (GO:0010833)2.74254573
127pyrimidine nucleotide catabolic process (GO:0006244)2.74098447
128cell differentiation in hindbrain (GO:0021533)2.73911560
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.73381369
130seminiferous tubule development (GO:0072520)2.73297384
131regulation of synapse structural plasticity (GO:0051823)2.73010482
132synaptic transmission (GO:0007268)2.71556110
133positive regulation of synaptic transmission (GO:0050806)2.71378708
134response to auditory stimulus (GO:0010996)2.71364321
135synapse assembly (GO:0007416)2.71199252
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69638094
137striatum development (GO:0021756)2.69608742
138negative regulation of inclusion body assembly (GO:0090084)2.69527756
139ATP synthesis coupled proton transport (GO:0015986)2.68240145
140energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68240145
141auditory behavior (GO:0031223)2.67995326
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.67245126
143regulation of double-strand break repair via homologous recombination (GO:0010569)2.66538239
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66030720
145mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65627189
146cell proliferation in forebrain (GO:0021846)2.63367233
147negative regulation of DNA recombination (GO:0045910)2.61482743
148regulation of cilium movement (GO:0003352)2.60325429
149DNA strand renaturation (GO:0000733)2.60075011
150negative regulation of hormone biosynthetic process (GO:0032353)2.59085015
151kinetochore assembly (GO:0051382)2.58011132
152double-strand break repair via homologous recombination (GO:0000724)2.54736069
153photoreceptor cell maintenance (GO:0045494)2.53005344
154recombinational repair (GO:0000725)2.52894443
155detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51046355
156urinary tract smooth muscle contraction (GO:0014848)2.49900012
157convergent extension (GO:0060026)2.49752568
158prenylation (GO:0097354)2.49225497
159protein prenylation (GO:0018342)2.49225497
160translational elongation (GO:0006414)2.48698257
161DNA topological change (GO:0006265)2.48317851
162cilium morphogenesis (GO:0060271)2.47607952
163kinetochore organization (GO:0051383)2.47253586
164nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46215227
165regulation of centrosome cycle (GO:0046605)2.46108308
166SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45075632
167otic vesicle formation (GO:0030916)2.44669553
168mitotic G2/M transition checkpoint (GO:0044818)2.44585984
169ncRNA catabolic process (GO:0034661)2.44351009
170protein insertion into membrane (GO:0051205)2.43528620
171radial glial cell differentiation (GO:0060019)2.43192396
172cotranslational protein targeting to membrane (GO:0006613)2.43122848
173maturation of SSU-rRNA (GO:0030490)2.42160436
174regulation of gene silencing by RNA (GO:0060966)2.41076375
175regulation of posttranscriptional gene silencing (GO:0060147)2.41076375
176regulation of gene silencing by miRNA (GO:0060964)2.41076375
177cerebral cortex radially oriented cell migration (GO:0021799)2.40362445
178determination of left/right symmetry (GO:0007368)2.39006277
179regulation of mesoderm development (GO:2000380)2.38651469
180regulation of centrosome duplication (GO:0010824)2.38177025
181centriole assembly (GO:0098534)2.37943586
182cellular modified amino acid catabolic process (GO:0042219)2.37154156
183determination of bilateral symmetry (GO:0009855)2.36372185
184cellular protein complex disassembly (GO:0043624)2.35370843
185mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.35139971
186protein targeting to ER (GO:0045047)2.33458891
187protein complex biogenesis (GO:0070271)2.29355236
188motile cilium assembly (GO:0044458)2.29199142
189establishment of protein localization to endoplasmic reticulum (GO:0072599)2.29070391
190inner ear receptor stereocilium organization (GO:0060122)2.28925756
191pituitary gland development (GO:0021983)2.28880432
192specification of symmetry (GO:0009799)2.28796696
193protein localization to endoplasmic reticulum (GO:0070972)2.28260185
194regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.28166387
195maturation of 5.8S rRNA (GO:0000460)2.27838074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80585473
2EZH2_22144423_ChIP-Seq_EOC_Human5.65485636
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.38829396
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.10565370
5GBX2_23144817_ChIP-Seq_PC3_Human3.70326119
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00905666
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99100296
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91375790
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.90669789
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72134875
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52698687
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45637554
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43144124
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42445317
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38952719
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38952719
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.36869756
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.36483471
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27958318
20REST_21632747_ChIP-Seq_MESCs_Mouse2.26805684
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.24289608
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23668351
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22521267
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18173831
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.17157502
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08946319
27DROSHA_22980978_ChIP-Seq_HELA_Human2.07778470
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.06814365
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.02528196
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99583226
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.97965190
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97733075
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.93917727
34AR_21572438_ChIP-Seq_LNCaP_Human1.93726291
35TAF15_26573619_Chip-Seq_HEK293_Human1.92010943
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.90291600
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89852711
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.89773385
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89536720
40ELK1_19687146_ChIP-ChIP_HELA_Human1.86386470
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82112643
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.75965222
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74941892
44* P300_19829295_ChIP-Seq_ESCs_Human1.72110687
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.70562147
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66789879
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64672536
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63577018
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62579865
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62433816
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62211120
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60610419
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.59394455
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56883717
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54044927
56FUS_26573619_Chip-Seq_HEK293_Human1.54036498
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.53076423
58IRF1_19129219_ChIP-ChIP_H3396_Human1.51991424
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49513500
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.49431454
61MYC_18940864_ChIP-ChIP_HL60_Human1.48310320
62RNF2_27304074_Chip-Seq_NSC_Mouse1.46930703
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.45539708
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.44376997
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.42333751
66AR_25329375_ChIP-Seq_VCAP_Human1.41958722
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40909842
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40267310
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38608978
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37626031
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36050929
72* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35934156
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35580546
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35406397
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34886832
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34349067
77TP53_22573176_ChIP-Seq_HFKS_Human1.32632980
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.31616826
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31413588
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.31322122
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.31064594
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31025494
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29600483
84* STAT3_23295773_ChIP-Seq_U87_Human1.28787248
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.27986438
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27503769
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26448538
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26001148
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23389110
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22686669
91ER_23166858_ChIP-Seq_MCF-7_Human1.21525674
92BCAT_22108803_ChIP-Seq_LS180_Human1.19765682
93* AHR_22903824_ChIP-Seq_MCF-7_Human1.19510353
94* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19349692
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.19214376
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19006105
97AR_21909140_ChIP-Seq_LNCAP_Human1.18165914
98* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17732080
99ZNF274_21170338_ChIP-Seq_K562_Hela1.17068001
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16849901
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15890881
102* TCF4_23295773_ChIP-Seq_U87_Human1.15657727
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15207346
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14773295
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14483047
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.12900932
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.12077895
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11580308
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10869273
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10686131
111* AR_19668381_ChIP-Seq_PC3_Human1.10414906
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08881577
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.08669921
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08030946
115TP53_18474530_ChIP-ChIP_U2OS_Human1.07274367
116IGF1R_20145208_ChIP-Seq_DFB_Human1.06454852
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05950483
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04994198
119VDR_22108803_ChIP-Seq_LS180_Human1.04331346
120* CBP_20019798_ChIP-Seq_JUKART_Human1.03218874
121* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03218874
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02798272
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02738643
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02648744
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02020462
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02020462
127TP53_16413492_ChIP-PET_HCT116_Human0.99850571
128SOX9_26525672_Chip-Seq_HEART_Mouse0.99407399
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99310940
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.97505931
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96989265
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.96869682
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96342969
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.96126274
135* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95712230
136MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95396774
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95325754
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95205595
139* RXR_22108803_ChIP-Seq_LS180_Human0.95143322
140TCF4_22108803_ChIP-Seq_LS180_Human0.94559087
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93953347
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.93936806
143EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93009141
144* JUN_21703547_ChIP-Seq_K562_Human0.92572410
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92269818
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92114449
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.91262146
148EWS_26573619_Chip-Seq_HEK293_Human0.91100271
149VDR_23849224_ChIP-Seq_CD4+_Human0.90702035
150* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90668500
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90482260
152MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87659398
153FOXP3_21729870_ChIP-Seq_TREG_Human0.87574648
154TTF2_22483619_ChIP-Seq_HELA_Human0.87560480
155FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85539708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.27838923
2MP0003880_abnormal_central_pattern4.67267515
3MP0003635_abnormal_synaptic_transmissio3.72409670
4MP0009745_abnormal_behavioral_response3.53712127
5MP0001968_abnormal_touch/_nociception3.22329871
6MP0002064_seizures3.12767054
7MP0004270_analgesia3.03494212
8MP0002063_abnormal_learning/memory/cond3.00574722
9MP0003121_genomic_imprinting2.95411423
10MP0003941_abnormal_skin_development2.94022512
11MP0009046_muscle_twitch2.91072378
12MP0005646_abnormal_pituitary_gland2.86423245
13MP0001440_abnormal_grooming_behavior2.83837680
14MP0002736_abnormal_nociception_after2.82351529
15MP0002572_abnormal_emotion/affect_behav2.77829492
16MP0002938_white_spotting2.77463560
17MP0005408_hypopigmentation2.55534928
18MP0002272_abnormal_nervous_system2.53528290
19MP0002734_abnormal_mechanical_nocicepti2.43648550
20MP0002822_catalepsy2.37966798
21MP0001501_abnormal_sleep_pattern2.37092833
22MP0001486_abnormal_startle_reflex2.29133458
23MP0005423_abnormal_somatic_nervous2.22919691
24MP0003890_abnormal_embryonic-extraembry2.20523945
25MP0008058_abnormal_DNA_repair2.13921882
26MP0005377_hearing/vestibular/ear_phenot2.12274541
27MP0003878_abnormal_ear_physiology2.12274541
28MP0009379_abnormal_foot_pigmentation2.11441912
29MP0002735_abnormal_chemical_nociception2.07463961
30MP0003122_maternal_imprinting2.05805319
31MP0002067_abnormal_sensory_capabilities1.95832383
32MP0001293_anophthalmia1.93930442
33MP0008004_abnormal_stomach_pH1.92659776
34MP0004147_increased_porphyrin_level1.92071724
35MP0008877_abnormal_DNA_methylation1.89254604
36MP0003937_abnormal_limbs/digits/tail_de1.87602155
37MP0009780_abnormal_chondrocyte_physiolo1.87461061
38MP0006276_abnormal_autonomic_nervous1.85640563
39MP0001905_abnormal_dopamine_level1.85231707
40MP0001502_abnormal_circadian_rhythm1.84940016
41MP0004142_abnormal_muscle_tone1.84332684
42MP0002557_abnormal_social/conspecific_i1.82562048
43MP0010094_abnormal_chromosome_stability1.81423181
44MP0001970_abnormal_pain_threshold1.81408139
45MP0000569_abnormal_digit_pigmentation1.80714597
46MP0002102_abnormal_ear_morphology1.80212607
47MP0002733_abnormal_thermal_nociception1.78567917
48MP0001984_abnormal_olfaction1.75623084
49MP0000778_abnormal_nervous_system1.73752535
50MP0005386_behavior/neurological_phenoty1.73244097
51MP0004924_abnormal_behavior1.73244097
52MP0008569_lethality_at_weaning1.68202906
53MP0000049_abnormal_middle_ear1.65077063
54MP0008932_abnormal_embryonic_tissue1.61234677
55MP0008995_early_reproductive_senescence1.53366350
56MP0002233_abnormal_nose_morphology1.51059695
57MP0004885_abnormal_endolymph1.50386949
58MP0008789_abnormal_olfactory_epithelium1.45656242
59MP0002184_abnormal_innervation1.44595482
60MP0002234_abnormal_pharynx_morphology1.42223883
61MP0001529_abnormal_vocalization1.41150123
62MP0003879_abnormal_hair_cell1.40179411
63MP0004957_abnormal_blastocyst_morpholog1.38882009
64MP0009697_abnormal_copulation1.36923531
65MP0003787_abnormal_imprinting1.35927139
66MP0002249_abnormal_larynx_morphology1.35855094
67MP0003329_amyloid_beta_deposits1.35840711
68MP0003136_yellow_coat_color1.35768150
69MP0004858_abnormal_nervous_system1.33658897
70MP0010030_abnormal_orbit_morphology1.33214379
71MP0002909_abnormal_adrenal_gland1.33167090
72MP0003690_abnormal_glial_cell1.32989490
73MP0002882_abnormal_neuron_morphology1.32638258
74MP0003283_abnormal_digestive_organ1.31116149
75MP0005645_abnormal_hypothalamus_physiol1.30348791
76MP0001188_hyperpigmentation1.30259737
77MP0000955_abnormal_spinal_cord1.22698820
78MP0002282_abnormal_trachea_morphology1.22151795
79MP0002066_abnormal_motor_capabilities/c1.21819602
80MP0003693_abnormal_embryo_hatching1.21437957
81MP0001286_abnormal_eye_development1.21431936
82MP0004145_abnormal_muscle_electrophysio1.21378529
83MP0005551_abnormal_eye_electrophysiolog1.19812303
84MP0004811_abnormal_neuron_physiology1.19394118
85MP0003111_abnormal_nucleus_morphology1.18497713
86MP0008057_abnormal_DNA_replication1.18142674
87MP0003633_abnormal_nervous_system1.17682022
88MP0002876_abnormal_thyroid_physiology1.17044984
89MP0002837_dystrophic_cardiac_calcinosis1.15039172
90MP0005171_absent_coat_pigmentation1.13311189
91MP0002697_abnormal_eye_size1.07131063
92MP0002152_abnormal_brain_morphology1.07078554
93MP0002084_abnormal_developmental_patter1.05831670
94MP0000751_myopathy1.04811117
95MP0000534_abnormal_ureter_morphology1.03420548
96MP0003935_abnormal_craniofacial_develop1.01863641
97MP0008872_abnormal_physiological_respon1.00425154
98MP0001929_abnormal_gametogenesis0.99946602
99MP0003755_abnormal_palate_morphology0.98880842
100MP0003631_nervous_system_phenotype0.98411716
101MP0003718_maternal_effect0.98159838
102MP0002160_abnormal_reproductive_system0.97152918
103MP0003634_abnormal_glial_cell0.96896588
104MP0003567_abnormal_fetal_cardiomyocyte0.96033041
105MP0010386_abnormal_urinary_bladder0.95226463
106MP0002210_abnormal_sex_determination0.94409239
107MP0002127_abnormal_cardiovascular_syste0.92077741
108MP0006072_abnormal_retinal_apoptosis0.91305124
109MP0004133_heterotaxia0.90806758
110MP0003698_abnormal_male_reproductive0.90368145
111MP0004085_abnormal_heartbeat0.90308987
112MP0003936_abnormal_reproductive_system0.89897877
113MP0001963_abnormal_hearing_physiology0.89843274
114MP0002069_abnormal_eating/drinking_beha0.89006743
115MP0002085_abnormal_embryonic_tissue0.88130003
116MP0000432_abnormal_head_morphology0.86187964
117MP0002116_abnormal_craniofacial_bone0.85213078
118MP0005380_embryogenesis_phenotype0.85070843
119MP0001672_abnormal_embryogenesis/_devel0.85070843
120MP0005195_abnormal_posterior_eye0.84990406
121MP0004197_abnormal_fetal_growth/weight/0.84862585
122MP0004742_abnormal_vestibular_system0.84319183
123MP0005623_abnormal_meninges_morphology0.84209953
124MP0002229_neurodegeneration0.84202421
125MP0003077_abnormal_cell_cycle0.83838874
126MP0002088_abnormal_embryonic_growth/wei0.83785748
127MP0009703_decreased_birth_body0.83763871
128MP0002111_abnormal_tail_morphology0.83567202
129MP0000428_abnormal_craniofacial_morphol0.83476319
130MP0002752_abnormal_somatic_nervous0.83452560
131MP0009672_abnormal_birth_weight0.82472345
132MP0003938_abnormal_ear_development0.82086408
133MP0000653_abnormal_sex_gland0.81881497
134MP0003984_embryonic_growth_retardation0.81109806
135MP0000631_abnormal_neuroendocrine_gland0.80485405
136MP0002638_abnormal_pupillary_reflex0.80023160
137MP0001145_abnormal_male_reproductive0.79385098
138MP0002653_abnormal_ependyma_morphology0.78167269
139MP0001485_abnormal_pinna_reflex0.78126679
140MP0000427_abnormal_hair_cycle0.76027842
141MP0005391_vision/eye_phenotype0.75830479
142MP0000372_irregular_coat_pigmentation0.75691581
143MP0001177_atelectasis0.74084881
144MP0005535_abnormal_body_temperature0.73228569
145MP0008874_decreased_physiological_sensi0.73210189
146MP0003632_abnormal_nervous_system0.72987613
147MP0003385_abnormal_body_wall0.72709703
148MP0005499_abnormal_olfactory_system0.72055177
149MP0005394_taste/olfaction_phenotype0.72055177
150MP0000026_abnormal_inner_ear0.72045347
151MP0002090_abnormal_vision0.71968201
152MP0005409_darkened_coat_color0.71375445
153MP0003137_abnormal_impulse_conducting0.66499502
154MP0000013_abnormal_adipose_tissue0.66426049
155MP0003075_altered_response_to0.65776038
156MP0004215_abnormal_myocardial_fiber0.63112887
157MP0009384_cardiac_valve_regurgitation0.62669477
158MP0006292_abnormal_olfactory_placode0.62217795
159MP0000920_abnormal_myelination0.61620422
160MP0001664_abnormal_digestion0.60990142
161MP0004484_altered_response_of0.58613998
162MP0001943_abnormal_respiration0.58600311
163MP0005253_abnormal_eye_physiology0.57371634
164MP0008961_abnormal_basal_metabolism0.56146995
165MP0003861_abnormal_nervous_system0.55342999

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.23687686
2Abnormal respiratory motile cilium physiology (HP:0012261)7.38397051
3Abnormal ciliary motility (HP:0012262)6.63158642
4Focal motor seizures (HP:0011153)6.35575351
5Rhinitis (HP:0012384)6.25704014
6Abnormal respiratory motile cilium morphology (HP:0005938)5.19889555
7Abnormal respiratory epithelium morphology (HP:0012253)5.19889555
8Absent/shortened dynein arms (HP:0200106)4.85887094
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.85887094
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.75619894
11Myokymia (HP:0002411)4.53975696
12Chromsome breakage (HP:0040012)4.45707618
13Chronic bronchitis (HP:0004469)4.43747336
14Focal seizures (HP:0007359)3.99729419
15Increased hepatocellular lipid droplets (HP:0006565)3.98602858
16Lipid accumulation in hepatocytes (HP:0006561)3.79355362
17Epileptic encephalopathy (HP:0200134)3.75734080
18Reticulocytopenia (HP:0001896)3.63563706
19Visual hallucinations (HP:0002367)3.48033353
20Pancreatic cysts (HP:0001737)3.40449408
21Septo-optic dysplasia (HP:0100842)3.25813913
22Atonic seizures (HP:0010819)3.15140732
23Renal Fanconi syndrome (HP:0001994)3.13837646
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.12845490
25Progressive cerebellar ataxia (HP:0002073)3.11924023
26Meckel diverticulum (HP:0002245)3.10337746
27Hyperventilation (HP:0002883)3.09072081
28Pancreatic fibrosis (HP:0100732)3.02535143
29Abnormality of the ileum (HP:0001549)3.00293383
30Dialeptic seizures (HP:0011146)2.98450583
31Abnormality of chromosome stability (HP:0003220)2.92266635
32Gait imbalance (HP:0002141)2.90924027
33Absence seizures (HP:0002121)2.90255470
34Febrile seizures (HP:0002373)2.83767618
35Generalized tonic-clonic seizures (HP:0002069)2.79440426
36Medial flaring of the eyebrow (HP:0010747)2.78971706
37True hermaphroditism (HP:0010459)2.78903257
38Abnormal eating behavior (HP:0100738)2.75300055
39Colon cancer (HP:0003003)2.71884248
40Aplasia involving bones of the extremities (HP:0009825)2.71031975
41Aplasia involving bones of the upper limbs (HP:0009823)2.71031975
42Aplasia of the phalanges of the hand (HP:0009802)2.71031975
43Abnormality of the preputium (HP:0100587)2.70731832
44Asplenia (HP:0001746)2.66274486
45Congenital primary aphakia (HP:0007707)2.65790333
46Broad-based gait (HP:0002136)2.65567551
47Abnormality of the carotid arteries (HP:0005344)2.64395636
48Tubular atrophy (HP:0000092)2.64255145
49Dysdiadochokinesis (HP:0002075)2.64078385
50Bronchiectasis (HP:0002110)2.60221984
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.56295912
52Abnormality of cochlea (HP:0000375)2.54927650
53Supernumerary spleens (HP:0009799)2.52502336
54Chronic hepatic failure (HP:0100626)2.52045418
55Gaze-evoked nystagmus (HP:0000640)2.52032663
56Ectopic kidney (HP:0000086)2.49484770
57Rhabdomyosarcoma (HP:0002859)2.48570522
58Cystic liver disease (HP:0006706)2.42727219
59Polyphagia (HP:0002591)2.41406298
60Median cleft lip (HP:0000161)2.41000445
61Nephrogenic diabetes insipidus (HP:0009806)2.38619312
62Truncal ataxia (HP:0002078)2.37278159
63Enlarged kidneys (HP:0000105)2.36506451
64Growth hormone deficiency (HP:0000824)2.36121804
65Triphalangeal thumb (HP:0001199)2.31714367
66Action tremor (HP:0002345)2.30681851
67Genital tract atresia (HP:0001827)2.30080894
68Anophthalmia (HP:0000528)2.28392209
69Abnormality of binocular vision (HP:0011514)2.27261298
70Diplopia (HP:0000651)2.27261298
71Molar tooth sign on MRI (HP:0002419)2.26234478
72Abnormality of midbrain morphology (HP:0002418)2.26234478
73Central scotoma (HP:0000603)2.25912540
74Vaginal atresia (HP:0000148)2.23872435
75Dysmetria (HP:0001310)2.21404590
76Renal dysplasia (HP:0000110)2.20834604
77Polydipsia (HP:0001959)2.20828846
78Abnormal drinking behavior (HP:0030082)2.20828846
79Tubulointerstitial nephritis (HP:0001970)2.20771657
80Abnormality of cells of the erythroid lineage (HP:0012130)2.20644502
81Abnormality of the diencephalon (HP:0010662)2.20166871
82Infertility (HP:0000789)2.19981596
83Cerebellar dysplasia (HP:0007033)2.18309421
84Anxiety (HP:0000739)2.18260731
85Supranuclear gaze palsy (HP:0000605)2.16080135
86Impaired vibration sensation in the lower limbs (HP:0002166)2.15245632
87Depression (HP:0000716)2.14926575
88Exertional dyspnea (HP:0002875)2.13707813
89Abnormality of the duodenum (HP:0002246)2.13445778
90Absent septum pellucidum (HP:0001331)2.12574862
91Abnormal hair whorl (HP:0010721)2.12297243
92Genetic anticipation (HP:0003743)2.11252795
93Abnormality of the labia minora (HP:0012880)2.10039014
94Amblyopia (HP:0000646)2.09418447
95Abnormality of the renal medulla (HP:0100957)2.09078312
96Excessive salivation (HP:0003781)2.07755948
97Drooling (HP:0002307)2.07755948
98Optic nerve hypoplasia (HP:0000609)2.07287278
99Tubulointerstitial fibrosis (HP:0005576)2.06932036
100Abnormality of dentin (HP:0010299)2.06353436
101Small intestinal stenosis (HP:0012848)2.04664261
102Duodenal stenosis (HP:0100867)2.04664261
103Tubulointerstitial abnormality (HP:0001969)2.04609631
104Papillary thyroid carcinoma (HP:0002895)2.04417772
105Abnormality of the renal cortex (HP:0011035)2.04415958
106Hyperthyroidism (HP:0000836)2.03785918
107Hemiparesis (HP:0001269)2.02679575
108Respiratory difficulties (HP:0002880)2.02455442
109Morphological abnormality of the inner ear (HP:0011390)2.01654337
110Facial shape deformation (HP:0011334)2.01404327
111Potter facies (HP:0002009)2.01404327
112Specific learning disability (HP:0001328)2.00971520
113Sloping forehead (HP:0000340)2.00526408
114Oligodactyly (hands) (HP:0001180)2.00225079
115Narrow nasal bridge (HP:0000446)1.99357996
116Vitreoretinal degeneration (HP:0000655)1.98750067
117Mitochondrial inheritance (HP:0001427)1.97361840
118Abnormal number of erythroid precursors (HP:0012131)1.96915161
119Occipital encephalocele (HP:0002085)1.95805795
120Poor coordination (HP:0002370)1.95150676
121Absent radius (HP:0003974)1.94844798
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94466577
123Hypoplastic pelvis (HP:0008839)1.94378253
124Horizontal nystagmus (HP:0000666)1.93519724
125Nephronophthisis (HP:0000090)1.93508321
126Acute necrotizing encephalopathy (HP:0006965)1.93479531
127Abnormality of renal resorption (HP:0011038)1.93074190
128Scanning speech (HP:0002168)1.93051687
129Duplicated collecting system (HP:0000081)1.92690680
130Increased intramyocellular lipid droplets (HP:0012240)1.92279512
131Abnormality of the dental root (HP:0006486)1.92152452
132Taurodontia (HP:0000679)1.92152452
133Abnormality of permanent molar morphology (HP:0011071)1.92152452
134Absent thumb (HP:0009777)1.90149379
135Urinary bladder sphincter dysfunction (HP:0002839)1.89864721
136Abnormality of the renal collecting system (HP:0004742)1.88364747
137Aplasia involving forearm bones (HP:0009822)1.88002870
138Absent forearm bone (HP:0003953)1.88002870
139Blue irides (HP:0000635)1.86657040
140Hemiplegia (HP:0002301)1.85348849
141Duplication of thumb phalanx (HP:0009942)1.81523722
142Bile duct proliferation (HP:0001408)1.81485419
143Abnormal biliary tract physiology (HP:0012439)1.81485419
144Abnormality of the nasal septum (HP:0000419)1.81179335
145Abnormality of the corticospinal tract (HP:0002492)1.80722928
146Psychosis (HP:0000709)1.80714697
147Tracheoesophageal fistula (HP:0002575)1.80604379
148Increased CSF lactate (HP:0002490)1.80163571
149Agitation (HP:0000713)1.79929372
150Abnormality of DNA repair (HP:0003254)1.79766519
151Neoplasm of striated muscle (HP:0009728)1.79475700
152Partial agenesis of the corpus callosum (HP:0001338)1.79379636
153Postural instability (HP:0002172)1.79312929
154Abnormality of molar (HP:0011077)1.78951871
155Abnormality of molar morphology (HP:0011070)1.78951871
156Congenital hepatic fibrosis (HP:0002612)1.78820738
157Chronic sinusitis (HP:0011109)1.78014595
158Abnormality of the septum pellucidum (HP:0007375)1.76961272
159Bifid tongue (HP:0010297)1.76578491
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.76462188
161Epileptiform EEG discharges (HP:0011182)1.76347411
162Oligodactyly (HP:0012165)1.75666947
163Diastasis recti (HP:0001540)1.75397192
164Birth length less than 3rd percentile (HP:0003561)1.74976985
165Horseshoe kidney (HP:0000085)1.74549964
166Abnormality of the lower motor neuron (HP:0002366)1.73578425
167Impaired smooth pursuit (HP:0007772)1.73431976
168Hyperphosphaturia (HP:0003109)1.72984662
169Renovascular hypertension (HP:0100817)1.72851003
170Abnormality of the dental pulp (HP:0006479)1.72230574
171Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72218535
172Degeneration of the lateral corticospinal tracts (HP:0002314)1.72218535
173Preaxial foot polydactyly (HP:0001841)1.71881796
174Neurofibrillary tangles (HP:0002185)1.71438438
175Broad distal phalanx of finger (HP:0009836)1.71263430
176Acute encephalopathy (HP:0006846)1.71112461
177Abnormal lung lobation (HP:0002101)1.70987443
178Torticollis (HP:0000473)1.70973649
179Postaxial foot polydactyly (HP:0001830)1.70888685
180Volvulus (HP:0002580)1.70754486
181Intestinal atresia (HP:0011100)1.70303364
182Dysmetric saccades (HP:0000641)1.68902926
183Intention tremor (HP:0002080)1.68835291
184Protruding tongue (HP:0010808)1.68171757
185Termporal pattern (HP:0011008)1.66742837
186Insidious onset (HP:0003587)1.66742837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.02665906
2CDC74.27150761
3PNCK3.87431834
4TNIK3.65284224
5EPHA43.33332285
6CASK3.09646845
7OBSCN3.07576660
8MAPK153.05980043
9MAP2K72.90203393
10MAP3K42.71976944
11ZAK2.60524942
12PLK42.57775184
13MARK12.37532509
14NTRK22.36118176
15MAP3K122.27986438
16MAP4K22.24619731
17PKN22.23418109
18MAP3K92.16982843
19NLK2.15439332
20MINK12.14919769
21TRIM281.97186365
22TTK1.96228145
23BCKDK1.90640027
24WNK31.86869131
25EPHB21.84625360
26BMPR1B1.77826705
27MAPK131.77696016
28DYRK21.76456227
29CCNB11.75775561
30DAPK21.69116051
31MAP2K41.66550022
32PIK3CA1.63304866
33STK161.57744340
34PRKCG1.55986798
35PASK1.55153434
36PRPF4B1.53790899
37FES1.53667814
38MKNK11.53629409
39PLK31.50470988
40NUAK11.45489836
41PBK1.42573868
42GRK51.35490037
43CDK51.33620632
44MKNK21.32359989
45BRSK21.32055768
46FLT31.30825352
47PAK61.30772760
48CHEK21.29940755
49SRPK11.29936629
50DAPK11.29849674
51VRK11.27039255
52CDK191.25887854
53RIPK41.25320641
54PLK21.24594487
55OXSR11.24117303
56MAP3K101.23231891
57CAMK2A1.21454318
58VRK21.20061523
59SGK2231.15920421
60SGK4941.15920421
61CAMK2B1.14212288
62PTK2B1.14203048
63SGK21.12710312
64NTRK11.09489948
65FRK1.09026083
66WEE11.05923756
67PRKD31.04415161
68PLK11.03562655
69AKT31.02140927
70ATR1.01520635
71ARAF1.00320985
72GRK10.99467132
73EIF2AK30.98863215
74DMPK0.96217682
75UHMK10.95737146
76CHEK10.95380529
77SIK20.93806084
78SIK30.89923263
79CAMKK10.88605446
80TAF10.88595343
81ADRBK20.88071389
82PRKCE0.87814148
83CAMKK20.85108155
84CDK30.84224737
85CSNK1G20.84075051
86LATS10.83188486
87BCR0.82123991
88NEK60.82041655
89TGFBR10.81209180
90KSR10.80011431
91CSNK1G10.79581351
92ALK0.79533167
93CDK40.78229489
94PHKG10.78227466
95PHKG20.78227466
96AURKB0.77594095
97FGFR10.77384791
98CAMK2D0.77069652
99PRKCH0.75915758
100MAPKAPK50.75742090
101BMPR20.75166625
102TSSK60.74218653
103MUSK0.73967436
104CDK180.73927866
105PAK30.71349772
106CDK150.69465915
107NME10.68810362
108STK40.68458985
109CAMK10.68087681
110SGK30.68010435
111CDK140.67908643
112MAP3K130.66880873
113FER0.66585830
114ATM0.66231321
115CDC42BPA0.65922530
116INSRR0.64298126
117KSR20.63252033
118CAMK1G0.62944268
119DYRK30.62542485
120CAMK2G0.62398307
121CDK11A0.61713876
122SGK10.60359289
123RPS6KA40.58388642
124LMTK20.57391591
125STK38L0.56197043
126TYRO30.55115030
127STK110.54547140
128DYRK1A0.53497411
129STK390.52595871
130AURKA0.51694832
131NEK20.51663726
132ACVR1B0.51061251
133ADRBK10.50771121
134RPS6KA20.50592402
135TNK20.50537970
136ROCK20.50284838
137PRKG10.49948216
138CDK10.48831316
139RPS6KA30.48569715
140EIF2AK20.47558961
141PRKACA0.47112187
142MARK20.46765226
143STK30.46159380
144SCYL20.46012390
145MAP3K60.45956203
146MAPK120.45563063
147CDK80.45222744
148TIE10.43867067
149FYN0.43471461
150FGR0.43264406
151GRK70.42529873
152MAPK70.41303203
153PRKDC0.40982429
154MYLK0.40732702
155PRKCA0.39234925
156ERBB30.37782347
157CSNK2A10.36523032
158PKN10.36437899
159CDK20.36274297
160CSNK1E0.36149380
161PRKACB0.34946861
162MELK0.34316941
163PRKCB0.34078678
164CSNK1A10.33961311
165CAMK40.33563247
166ROCK10.31773702
167CSNK2A20.30434564
168NEK10.30031805
169MST40.30007903

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94046864
2DNA replication_Homo sapiens_hsa030303.67161579
3Homologous recombination_Homo sapiens_hsa034403.36447238
4Mismatch repair_Homo sapiens_hsa034303.13293976
5Ribosome_Homo sapiens_hsa030103.11888083
6Fanconi anemia pathway_Homo sapiens_hsa034603.08437989
7Synaptic vesicle cycle_Homo sapiens_hsa047212.99992316
8GABAergic synapse_Homo sapiens_hsa047272.95983084
9Circadian entrainment_Homo sapiens_hsa047132.93323722
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76062674
11Morphine addiction_Homo sapiens_hsa050322.63729199
12Olfactory transduction_Homo sapiens_hsa047402.63657796
13Glutamatergic synapse_Homo sapiens_hsa047242.57210694
14Amphetamine addiction_Homo sapiens_hsa050312.53112861
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.41450186
16Long-term potentiation_Homo sapiens_hsa047202.37552546
17RNA polymerase_Homo sapiens_hsa030202.25943062
18Collecting duct acid secretion_Homo sapiens_hsa049662.15004044
19One carbon pool by folate_Homo sapiens_hsa006702.14708237
20RNA degradation_Homo sapiens_hsa030182.11974167
21Insulin secretion_Homo sapiens_hsa049112.01942680
22Dopaminergic synapse_Homo sapiens_hsa047282.01763649
23Cocaine addiction_Homo sapiens_hsa050301.93315790
24Salivary secretion_Homo sapiens_hsa049701.93047035
25Gastric acid secretion_Homo sapiens_hsa049711.85370354
26Proteasome_Homo sapiens_hsa030501.83395337
27Taste transduction_Homo sapiens_hsa047421.81340433
28Serotonergic synapse_Homo sapiens_hsa047261.81159271
29Basal transcription factors_Homo sapiens_hsa030221.75145603
30Cholinergic synapse_Homo sapiens_hsa047251.73254807
31RNA transport_Homo sapiens_hsa030131.72425031
32Long-term depression_Homo sapiens_hsa047301.71860731
33Renin secretion_Homo sapiens_hsa049241.69502879
34Calcium signaling pathway_Homo sapiens_hsa040201.67309749
35Oxidative phosphorylation_Homo sapiens_hsa001901.65367574
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65047660
37Nucleotide excision repair_Homo sapiens_hsa034201.61043772
38Non-homologous end-joining_Homo sapiens_hsa034501.60851748
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60761764
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56694871
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54501873
42Base excision repair_Homo sapiens_hsa034101.49344952
43Oxytocin signaling pathway_Homo sapiens_hsa049211.48727990
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48667131
45Pyrimidine metabolism_Homo sapiens_hsa002401.45476749
46Hedgehog signaling pathway_Homo sapiens_hsa043401.41761352
47Vibrio cholerae infection_Homo sapiens_hsa051101.41372564
48Spliceosome_Homo sapiens_hsa030401.37390733
49Cardiac muscle contraction_Homo sapiens_hsa042601.36906706
50GnRH signaling pathway_Homo sapiens_hsa049121.32064140
51Sulfur relay system_Homo sapiens_hsa041221.31369573
52Cell cycle_Homo sapiens_hsa041101.29423917
53Steroid biosynthesis_Homo sapiens_hsa001001.29396974
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28462496
55cAMP signaling pathway_Homo sapiens_hsa040241.26658316
56Basal cell carcinoma_Homo sapiens_hsa052171.26037033
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25612901
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23332243
59Huntingtons disease_Homo sapiens_hsa050161.23085791
60Folate biosynthesis_Homo sapiens_hsa007901.22482257
61Alzheimers disease_Homo sapiens_hsa050101.22295288
62Purine metabolism_Homo sapiens_hsa002301.21812700
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.18844661
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17834848
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17817981
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17620778
67Gap junction_Homo sapiens_hsa045401.15573692
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14624957
69mRNA surveillance pathway_Homo sapiens_hsa030151.14243438
70Estrogen signaling pathway_Homo sapiens_hsa049151.13575658
71Propanoate metabolism_Homo sapiens_hsa006401.11952562
72Parkinsons disease_Homo sapiens_hsa050121.11345849
73Phototransduction_Homo sapiens_hsa047441.11220392
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10095315
75Protein export_Homo sapiens_hsa030601.09128015
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04885632
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02759282
78Primary bile acid biosynthesis_Homo sapiens_hsa001201.00552654
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98796046
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97915135
81Axon guidance_Homo sapiens_hsa043600.96839989
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.96818453
83Glutathione metabolism_Homo sapiens_hsa004800.92878636
84Melanogenesis_Homo sapiens_hsa049160.91749405
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91273050
86Circadian rhythm_Homo sapiens_hsa047100.88639874
87Linoleic acid metabolism_Homo sapiens_hsa005910.86177248
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84296615
89Type II diabetes mellitus_Homo sapiens_hsa049300.83762010
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79860974
91Hippo signaling pathway_Homo sapiens_hsa043900.78581259
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78386108
93ErbB signaling pathway_Homo sapiens_hsa040120.76264793
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76001729
95Peroxisome_Homo sapiens_hsa041460.74478119
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74188460
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73980453
98Dilated cardiomyopathy_Homo sapiens_hsa054140.72632001
99Fatty acid metabolism_Homo sapiens_hsa012120.71693329
100Thyroid hormone synthesis_Homo sapiens_hsa049180.70382706
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69381430
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69038237
103Ether lipid metabolism_Homo sapiens_hsa005650.68337468
104Selenocompound metabolism_Homo sapiens_hsa004500.67822569
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67728123
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67305991
107Pancreatic secretion_Homo sapiens_hsa049720.67245060
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66845630
109Glycerolipid metabolism_Homo sapiens_hsa005610.66600954
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65941934
111Glioma_Homo sapiens_hsa052140.65822744
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64811749
113TGF-beta signaling pathway_Homo sapiens_hsa043500.64530800
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.64081635
115Butanoate metabolism_Homo sapiens_hsa006500.63724859
116Ovarian steroidogenesis_Homo sapiens_hsa049130.63140578
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.61175523
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59875603
119Rheumatoid arthritis_Homo sapiens_hsa053230.59065178
120Caffeine metabolism_Homo sapiens_hsa002320.57434710
121Choline metabolism in cancer_Homo sapiens_hsa052310.57054158
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56970976
123Metabolic pathways_Homo sapiens_hsa011000.56966854
124Prion diseases_Homo sapiens_hsa050200.56518294
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56208873
126Retinol metabolism_Homo sapiens_hsa008300.54632432
127MAPK signaling pathway_Homo sapiens_hsa040100.54354359
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53770949
129Fat digestion and absorption_Homo sapiens_hsa049750.53584187
130Tight junction_Homo sapiens_hsa045300.52709875
131Type I diabetes mellitus_Homo sapiens_hsa049400.47867386
132Ras signaling pathway_Homo sapiens_hsa040140.47362030
133Dorso-ventral axis formation_Homo sapiens_hsa043200.47167329
134Chemical carcinogenesis_Homo sapiens_hsa052040.47071781
135Protein digestion and absorption_Homo sapiens_hsa049740.46530788
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46501645
137Bile secretion_Homo sapiens_hsa049760.45888159
138Fatty acid degradation_Homo sapiens_hsa000710.45799575
139Glucagon signaling pathway_Homo sapiens_hsa049220.42882580
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41858645
141Alcoholism_Homo sapiens_hsa050340.41045433
142Oocyte meiosis_Homo sapiens_hsa041140.40910278
143Pyruvate metabolism_Homo sapiens_hsa006200.40690491
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.39613345
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38605796
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37633706
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37380210
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36655679
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36584996
150Phagosome_Homo sapiens_hsa041450.36104810
151Wnt signaling pathway_Homo sapiens_hsa043100.34429522
152Rap1 signaling pathway_Homo sapiens_hsa040150.33684038
153Tryptophan metabolism_Homo sapiens_hsa003800.32761769
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31276948
155Arachidonic acid metabolism_Homo sapiens_hsa005900.31100629
156Nitrogen metabolism_Homo sapiens_hsa009100.28708692
157Mineral absorption_Homo sapiens_hsa049780.28535067
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27268194
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25485545
160Fatty acid biosynthesis_Homo sapiens_hsa000610.24868650
161Inositol phosphate metabolism_Homo sapiens_hsa005620.24814911
162African trypanosomiasis_Homo sapiens_hsa051430.23879741
163Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23843211
164Renal cell carcinoma_Homo sapiens_hsa052110.23439962
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.22246938
166Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21524759
167Neurotrophin signaling pathway_Homo sapiens_hsa047220.21082160

Most similar genes based on co-expression Upload to Enrichr

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