SYT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.14580571
2axon ensheathment in central nervous system (GO:0032291)8.14580571
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.64297407
4fatty acid elongation (GO:0030497)5.10711026
5cellular potassium ion homeostasis (GO:0030007)5.07616941
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.05466823
7myelination (GO:0042552)5.01365178
8axon ensheathment (GO:0008366)4.99104973
9ensheathment of neurons (GO:0007272)4.99104973
10neuron cell-cell adhesion (GO:0007158)4.96686445
11long-chain fatty acid biosynthetic process (GO:0042759)4.81021570
12presynaptic membrane assembly (GO:0097105)4.71720902
13presynaptic membrane organization (GO:0097090)4.71083099
14sodium ion export (GO:0071436)4.58277852
15neurotransmitter secretion (GO:0007269)4.39028982
16neurotransmitter-gated ion channel clustering (GO:0072578)4.35107127
17neuronal action potential propagation (GO:0019227)4.26672543
18pyrimidine nucleobase catabolic process (GO:0006208)4.22480307
19regulation of synapse structural plasticity (GO:0051823)4.13611412
20transmission of nerve impulse (GO:0019226)3.92328231
21L-amino acid import (GO:0043092)3.84253921
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83156419
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66250400
24response to auditory stimulus (GO:0010996)3.66102471
25potassium ion import (GO:0010107)3.64685717
26potassium ion homeostasis (GO:0055075)3.63803085
27establishment of mitochondrion localization (GO:0051654)3.60938883
28neurotransmitter transport (GO:0006836)3.60889470
29oligodendrocyte differentiation (GO:0048709)3.58761699
30synaptic vesicle exocytosis (GO:0016079)3.57187039
31neuron recognition (GO:0008038)3.56311182
32adult walking behavior (GO:0007628)3.50528935
33positive regulation of synapse maturation (GO:0090129)3.50176413
34nucleobase catabolic process (GO:0046113)3.49788908
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.47068471
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46665964
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.45729528
38vocalization behavior (GO:0071625)3.42060723
39synaptic vesicle endocytosis (GO:0048488)3.38047173
40negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.37835593
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.37561765
42protein localization to synapse (GO:0035418)3.37000453
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.36855178
44cell communication by electrical coupling (GO:0010644)3.35589363
45glycerophospholipid catabolic process (GO:0046475)3.35243302
46regulation of neurotransmitter levels (GO:0001505)3.34866676
47regulation of collateral sprouting (GO:0048670)3.32545091
48neuromuscular synaptic transmission (GO:0007274)3.31069656
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30434467
50* regulation of neurotransmitter secretion (GO:0046928)3.30393236
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29719405
52apical protein localization (GO:0045176)3.29590726
53neuronal ion channel clustering (GO:0045161)3.28378632
54substantia nigra development (GO:0021762)3.27383913
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.27336453
56synapse assembly (GO:0007416)3.27326987
57negative regulation of protein localization to cell surface (GO:2000009)3.25577384
58cellular sodium ion homeostasis (GO:0006883)3.25300351
59glutamate receptor signaling pathway (GO:0007215)3.23171723
60positive regulation of dendritic spine development (GO:0060999)3.23087377
61cell migration in hindbrain (GO:0021535)3.23066507
62regulation of synaptic vesicle exocytosis (GO:2000300)3.22303694
63synaptic vesicle maturation (GO:0016188)3.21021329
64glutamate secretion (GO:0014047)3.20885082
65* regulation of neurotransmitter transport (GO:0051588)3.18629227
66cerebellar granule cell differentiation (GO:0021707)3.18049612
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17894506
68membrane depolarization during action potential (GO:0086010)3.17774380
69dendritic spine morphogenesis (GO:0060997)3.17697116
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16389659
71acidic amino acid transport (GO:0015800)3.14326886
72cerebellar Purkinje cell differentiation (GO:0021702)3.13644994
73axonal fasciculation (GO:0007413)3.13103838
74regulation of vesicle fusion (GO:0031338)3.12978482
75neuromuscular process controlling balance (GO:0050885)3.11642302
76central nervous system projection neuron axonogenesis (GO:0021952)3.11256229
77neuron-neuron synaptic transmission (GO:0007270)3.10951583
78* negative regulation of neurotransmitter transport (GO:0051589)3.10380792
79long-term memory (GO:0007616)3.10093222
80cerebral cortex radially oriented cell migration (GO:0021799)3.09380710
81startle response (GO:0001964)3.08725540
82myelin maintenance (GO:0043217)3.07636487
83synaptic transmission, glutamatergic (GO:0035249)3.07589383
84negative regulation of axonogenesis (GO:0050771)3.06976490
85locomotory exploration behavior (GO:0035641)3.06792563
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.06561675
87photoreceptor cell differentiation (GO:0046530)3.06437058
88eye photoreceptor cell differentiation (GO:0001754)3.06437058
89regulation of synaptic plasticity (GO:0048167)3.04741116
90asymmetric protein localization (GO:0008105)3.04219964
91positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02346145
92amino acid import (GO:0043090)3.02073760
93membrane depolarization (GO:0051899)3.01939012
94gamma-aminobutyric acid transport (GO:0015812)3.00241383
95positive regulation of action potential (GO:0045760)2.98715828
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98091465
97neuron remodeling (GO:0016322)2.95954556
98regulation of respiratory system process (GO:0044065)2.94922311
99astrocyte development (GO:0014002)2.94371293
100mating behavior (GO:0007617)2.94199542
101synapse organization (GO:0050808)2.92360048
102neurotransmitter uptake (GO:0001504)2.92067241
103response to methylmercury (GO:0051597)2.90943645
104regulation of synapse maturation (GO:0090128)2.85505037
105regulation of neuronal synaptic plasticity (GO:0048168)2.83356111
106cholesterol biosynthetic process (GO:0006695)2.81424007
107negative regulation of axon extension (GO:0030517)2.80307893
108peptidyl-tyrosine autophosphorylation (GO:0038083)2.79565454
109membrane assembly (GO:0071709)2.76511217
110postsynaptic membrane organization (GO:0001941)2.76499592
111regulation of glutamate receptor signaling pathway (GO:1900449)2.75479287
112positive regulation of synapse assembly (GO:0051965)2.74772393
113positive regulation of membrane potential (GO:0045838)2.73336332
114cellular response to epinephrine stimulus (GO:0071872)2.72853222
115response to redox state (GO:0051775)2.71042828
116regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69856719
117regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69439186
118regulation of dopamine metabolic process (GO:0042053)2.68690160
119regulation of catecholamine metabolic process (GO:0042069)2.68690160
120regulation of voltage-gated calcium channel activity (GO:1901385)2.68271997
121regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67867886
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66762276
123regulation of dendritic spine morphogenesis (GO:0061001)2.66580947
124regulation of glutamate secretion (GO:0014048)2.66244450
125regulation of synaptic vesicle transport (GO:1902803)2.65884558
126dendrite morphogenesis (GO:0048813)2.64357151
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62919714
128detection of temperature stimulus involved in sensory perception (GO:0050961)2.62822964
129detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.62822964
130membrane hyperpolarization (GO:0060081)2.60344280
131dendrite development (GO:0016358)2.60112743
132protein palmitoylation (GO:0018345)2.60067229
133positive regulation of oligodendrocyte differentiation (GO:0048714)2.59749280
134G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56929237
135long-term synaptic potentiation (GO:0060291)2.56563120
136auditory behavior (GO:0031223)2.56091613
137response to epinephrine (GO:0071871)2.55748447
138regulation of postsynaptic membrane potential (GO:0060078)2.55524854
139regulation of dendritic spine development (GO:0060998)2.55139966
140adult locomotory behavior (GO:0008344)2.52654250
141exploration behavior (GO:0035640)2.51632357
142neurotransmitter catabolic process (GO:0042135)2.51151044
143layer formation in cerebral cortex (GO:0021819)2.50885319
144mechanosensory behavior (GO:0007638)2.50555557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.54522841
2GBX2_23144817_ChIP-Seq_PC3_Human3.86040121
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95697610
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89034135
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85774610
6TAF15_26573619_Chip-Seq_HEK293_Human2.60224666
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50496932
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50496932
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.49963520
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42891222
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39556134
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37046532
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34377082
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33328959
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.31855498
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26639668
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11832634
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.11789001
19SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.11482341
20REST_21632747_ChIP-Seq_MESCs_Mouse2.02088496
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00860532
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.99309405
23AR_21572438_ChIP-Seq_LNCaP_Human1.93538806
24DROSHA_22980978_ChIP-Seq_HELA_Human1.88650309
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87205041
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79458992
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78481035
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.77538609
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72664572
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.69874265
31VDR_22108803_ChIP-Seq_LS180_Human1.65817061
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63756984
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.63516763
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60211811
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59954107
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59817367
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58047325
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57626931
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55467472
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.55317246
41P300_19829295_ChIP-Seq_ESCs_Human1.54900429
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54769826
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50972849
44ER_23166858_ChIP-Seq_MCF-7_Human1.48966368
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46690943
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46525113
47SMAD4_21799915_ChIP-Seq_A2780_Human1.45491822
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44346075
49RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43268660
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.40022036
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39795789
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38898080
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38219475
54FUS_26573619_Chip-Seq_HEK293_Human1.37770837
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34871867
56RNF2_27304074_Chip-Seq_NSC_Mouse1.31480422
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29155578
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27042401
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27029625
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23334848
61STAT3_23295773_ChIP-Seq_U87_Human1.23322635
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22414382
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20246887
64AR_19668381_ChIP-Seq_PC3_Human1.16050100
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14766495
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14234837
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13196661
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12710518
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12010795
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11662141
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11436784
72STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10924879
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.10329083
74TCF4_23295773_ChIP-Seq_U87_Human1.10025220
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.09407627
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09129603
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.08667066
78ZNF274_21170338_ChIP-Seq_K562_Hela1.08172590
79IGF1R_20145208_ChIP-Seq_DFB_Human1.08129763
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.06550754
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.05930315
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03527025
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03309834
84AR_25329375_ChIP-Seq_VCAP_Human1.02829807
85RUNX2_22187159_ChIP-Seq_PCA_Human1.02139431
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01652877
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01432562
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.00828900
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.00108069
90WT1_19549856_ChIP-ChIP_CCG9911_Human0.99016563
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98664458
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98416345
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98380555
94CMYC_18555785_Chip-Seq_ESCs_Mouse0.97138426
95AHR_22903824_ChIP-Seq_MCF-7_Human0.96213316
96* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96194562
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95900953
98ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95461410
99SOX9_26525672_Chip-Seq_HEART_Mouse0.94616317
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94466925
101GATA1_26923725_Chip-Seq_HPCs_Mouse0.94407623
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94377752
103JUN_21703547_ChIP-Seq_K562_Human0.93190826
104TAL1_26923725_Chip-Seq_HPCs_Mouse0.92717506
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92431641
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91460909
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91001994
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.90663931
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.89960801
110KDM2B_26808549_Chip-Seq_REH_Human0.88136515
111SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87759393
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87331386
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86604166
114TP53_18474530_ChIP-ChIP_U2OS_Human0.86514670
115P300_18555785_Chip-Seq_ESCs_Mouse0.86409810
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.85850250
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85396015
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85396015
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.85208563
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84828304
121P53_22387025_ChIP-Seq_ESCs_Mouse0.84619379
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84350969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.13617674
2MP0004859_abnormal_synaptic_plasticity4.13609068
3MP0004270_analgesia3.77233957
4MP0000920_abnormal_myelination3.36884900
5MP0003635_abnormal_synaptic_transmissio3.07982310
6MP0002064_seizures2.96114581
7MP0002272_abnormal_nervous_system2.87305561
8MP0009745_abnormal_behavioral_response2.82444054
9MP0001486_abnormal_startle_reflex2.74584433
10MP0009046_muscle_twitch2.73481000
11MP0001529_abnormal_vocalization2.66656063
12MP0002734_abnormal_mechanical_nocicepti2.46006726
13MP0003329_amyloid_beta_deposits2.45961394
14MP0005423_abnormal_somatic_nervous2.44875151
15MP0002063_abnormal_learning/memory/cond2.38830807
16MP0001968_abnormal_touch/_nociception2.36671781
17MP0000778_abnormal_nervous_system2.34952244
18MP0001905_abnormal_dopamine_level2.29310989
19MP0002572_abnormal_emotion/affect_behav2.28734051
20MP0004885_abnormal_endolymph2.14900269
21MP0004742_abnormal_vestibular_system2.14164371
22MP0003690_abnormal_glial_cell2.07563469
23MP0004142_abnormal_muscle_tone2.06751408
24MP0001440_abnormal_grooming_behavior2.05810277
25MP0002736_abnormal_nociception_after2.00547179
26MP0002735_abnormal_chemical_nociception1.94762342
27MP0002067_abnormal_sensory_capabilities1.88044399
28MP0001970_abnormal_pain_threshold1.84081929
29MP0002733_abnormal_thermal_nociception1.81760612
30MP0003136_yellow_coat_color1.79627428
31MP0003634_abnormal_glial_cell1.78887211
32MP0005171_absent_coat_pigmentation1.77559472
33MP0002638_abnormal_pupillary_reflex1.76615225
34MP0005409_darkened_coat_color1.73813015
35MP0002822_catalepsy1.70569539
36MP0001501_abnormal_sleep_pattern1.68832805
37MP0001485_abnormal_pinna_reflex1.68370177
38MP0006276_abnormal_autonomic_nervous1.67329114
39MP0000955_abnormal_spinal_cord1.66061107
40MP0004924_abnormal_behavior1.63026172
41MP0005386_behavior/neurological_phenoty1.63026172
42MP0008569_lethality_at_weaning1.58832737
43MP0002229_neurodegeneration1.58562647
44MP0002882_abnormal_neuron_morphology1.57065403
45MP0002184_abnormal_innervation1.50499633
46MP0002066_abnormal_motor_capabilities/c1.45424554
47MP0003632_abnormal_nervous_system1.41687405
48MP0003950_abnormal_plasma_membrane1.40273474
49MP0002557_abnormal_social/conspecific_i1.36513388
50MP0005551_abnormal_eye_electrophysiolog1.36409601
51MP0001984_abnormal_olfaction1.28017155
52MP0003631_nervous_system_phenotype1.27926070
53MP0002653_abnormal_ependyma_morphology1.25066746
54MP0000569_abnormal_digit_pigmentation1.25020757
55MP0001963_abnormal_hearing_physiology1.23770896
56MP0005410_abnormal_fertilization1.23168767
57MP0003633_abnormal_nervous_system1.20951050
58MP0002752_abnormal_somatic_nervous1.19084656
59MP0005646_abnormal_pituitary_gland1.16498594
60MP0002909_abnormal_adrenal_gland1.15778741
61MP0000604_amyloidosis1.15123026
62MP0004811_abnormal_neuron_physiology1.14235310
63MP0005645_abnormal_hypothalamus_physiol1.13724897
64MP0004145_abnormal_muscle_electrophysio1.08102530
65MP0003121_genomic_imprinting1.07566476
66MP0001188_hyperpigmentation1.07480697
67MP0002152_abnormal_brain_morphology1.06983752
68MP0001502_abnormal_circadian_rhythm1.05192833
69MP0005499_abnormal_olfactory_system1.03276938
70MP0005394_taste/olfaction_phenotype1.03276938
71MP0004858_abnormal_nervous_system1.00193082
72MP0009780_abnormal_chondrocyte_physiolo0.99094371
73MP0000462_abnormal_digestive_system0.96789663
74MP0004043_abnormal_pH_regulation0.94968650
75MP0001299_abnormal_eye_distance/0.90300741
76MP0000026_abnormal_inner_ear0.89681921
77MP0003123_paternal_imprinting0.89256779
78MP0003938_abnormal_ear_development0.84620316
79MP0000631_abnormal_neuroendocrine_gland0.83367315
80MP0005623_abnormal_meninges_morphology0.80848459
81MP0001177_atelectasis0.79480283
82MP0006072_abnormal_retinal_apoptosis0.78610690
83MP0003283_abnormal_digestive_organ0.78554770
84MP0008260_abnormal_autophagy0.78501440
85MP0010386_abnormal_urinary_bladder0.77502989
86MP0003122_maternal_imprinting0.77091186
87MP0005187_abnormal_penis_morphology0.76966608
88MP0004134_abnormal_chest_morphology0.76433834
89MP0000747_muscle_weakness0.74177445
90MP0005195_abnormal_posterior_eye0.73439457
91MP0005167_abnormal_blood-brain_barrier0.72596243
92MP0006292_abnormal_olfactory_placode0.71094689
93MP0008877_abnormal_DNA_methylation0.69620522
94MP0002069_abnormal_eating/drinking_beha0.69383823
95MP0005253_abnormal_eye_physiology0.68526381
96MP0004147_increased_porphyrin_level0.66459424
97MP0004381_abnormal_hair_follicle0.66258380
98MP0003137_abnormal_impulse_conducting0.65303858
99MP0010678_abnormal_skin_adnexa0.65201953
100MP0008874_decreased_physiological_sensi0.64672325
101MP0001664_abnormal_digestion0.64592128
102MP0002090_abnormal_vision0.64314347
103MP0000751_myopathy0.62443839
104MP0004085_abnormal_heartbeat0.62316020
105MP0001943_abnormal_respiration0.61795509
106MP0010769_abnormal_survival0.61200446
107MP0010770_preweaning_lethality0.61180640
108MP0002082_postnatal_lethality0.61180640
109MP0004133_heterotaxia0.61048528
110MP0003861_abnormal_nervous_system0.60850261
111MP0001986_abnormal_taste_sensitivity0.60825822
112MP0002751_abnormal_autonomic_nervous0.58736559
113MP0003787_abnormal_imprinting0.57712627
114MP0010768_mortality/aging0.57558729
115MP0003879_abnormal_hair_cell0.56463886
116MP0002102_abnormal_ear_morphology0.56069612
117MP0008789_abnormal_olfactory_epithelium0.55104781
118MP0000383_abnormal_hair_follicle0.54113052
119MP0000566_synostosis0.52888275
120MP0001346_abnormal_lacrimal_gland0.52689317
121MP0008872_abnormal_physiological_respon0.51540514

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.53991767
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.53991767
3Neurofibrillary tangles (HP:0002185)5.39224890
4Focal motor seizures (HP:0011153)4.84678050
5Myokymia (HP:0002411)4.62204979
6Abnormality of the corticospinal tract (HP:0002492)4.56683423
7Cerebral inclusion bodies (HP:0100314)4.24414986
8Supranuclear gaze palsy (HP:0000605)4.01561093
9Sensory axonal neuropathy (HP:0003390)3.98899504
10Peripheral hypomyelination (HP:0007182)3.84810152
11Atonic seizures (HP:0010819)3.71077449
12Focal seizures (HP:0007359)3.55068562
13Spastic gait (HP:0002064)3.54327234
14Parakeratosis (HP:0001036)3.52466248
15Hemiplegia (HP:0002301)3.51748486
16Dysmetria (HP:0001310)3.38589822
17Termporal pattern (HP:0011008)3.37654920
18Insidious onset (HP:0003587)3.37654920
19Epileptic encephalopathy (HP:0200134)3.29771381
20Polyphagia (HP:0002591)3.25210993
21Ankle clonus (HP:0011448)3.03892164
22Scanning speech (HP:0002168)2.96923296
23Intention tremor (HP:0002080)2.95673053
24Retinal dysplasia (HP:0007973)2.93178672
25Epileptiform EEG discharges (HP:0011182)2.91432516
26Mutism (HP:0002300)2.88485158
27Onion bulb formation (HP:0003383)2.86049381
28Akinesia (HP:0002304)2.82462545
29Torticollis (HP:0000473)2.81869147
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81493096
31Hyperventilation (HP:0002883)2.77857941
32Dialeptic seizures (HP:0011146)2.74881085
33Pheochromocytoma (HP:0002666)2.73041939
34Cerebral hypomyelination (HP:0006808)2.72367769
35Action tremor (HP:0002345)2.71200280
36Broad-based gait (HP:0002136)2.68137423
37EEG with generalized epileptiform discharges (HP:0011198)2.66925888
38Progressive cerebellar ataxia (HP:0002073)2.59729527
39Thickened helices (HP:0000391)2.59430994
40Absence seizures (HP:0002121)2.58987174
41Alacrima (HP:0000522)2.58152772
42Postural instability (HP:0002172)2.58135777
43Hypsarrhythmia (HP:0002521)2.57468848
44Amblyopia (HP:0000646)2.56869509
45Sleep apnea (HP:0010535)2.52137558
46Abnormality of the lower motor neuron (HP:0002366)2.49103632
47Status epilepticus (HP:0002133)2.47872083
48Neuroendocrine neoplasm (HP:0100634)2.45074019
49Papilledema (HP:0001085)2.42198953
50Gaze-evoked nystagmus (HP:0000640)2.41586088
51Leukodystrophy (HP:0002415)2.39867634
52Lower limb muscle weakness (HP:0007340)2.39668694
53Megalencephaly (HP:0001355)2.36123495
54Visual hallucinations (HP:0002367)2.34804709
55Dysdiadochokinesis (HP:0002075)2.34375809
56Focal dystonia (HP:0004373)2.33663997
57Generalized tonic-clonic seizures (HP:0002069)2.29869639
58Amyotrophic lateral sclerosis (HP:0007354)2.29841812
59Abnormality of glycolysis (HP:0004366)2.29732830
60Increased serum pyruvate (HP:0003542)2.29732830
61Progressive inability to walk (HP:0002505)2.27282807
62Limb dystonia (HP:0002451)2.26599915
63Febrile seizures (HP:0002373)2.26173075
64Slow saccadic eye movements (HP:0000514)2.24525022
65Depression (HP:0000716)2.22976575
66Obstructive sleep apnea (HP:0002870)2.22658937
67Clumsiness (HP:0002312)2.20932023
68Abnormal auditory evoked potentials (HP:0006958)2.20468578
69Urinary bladder sphincter dysfunction (HP:0002839)2.16569843
70Generalized myoclonic seizures (HP:0002123)2.16160012
71Truncal ataxia (HP:0002078)2.14160279
72Cerebral hemorrhage (HP:0001342)2.13898072
73Aplasia involving bones of the upper limbs (HP:0009823)2.10139557
74Aplasia of the phalanges of the hand (HP:0009802)2.10139557
75Aplasia involving bones of the extremities (HP:0009825)2.10139557
76Urinary urgency (HP:0000012)2.09916896
77Vaginal atresia (HP:0000148)2.08565086
78Annular pancreas (HP:0001734)2.08375308
79Genetic anticipation (HP:0003743)2.07931841
80Spastic tetraplegia (HP:0002510)2.07059038
81Split foot (HP:0001839)2.06811240
82Craniofacial dystonia (HP:0012179)2.06270907
83Specific learning disability (HP:0001328)2.06170871
84Poor eye contact (HP:0000817)2.05736623
85Spastic tetraparesis (HP:0001285)2.04780313
86Increased circulating renin level (HP:0000848)2.04337662
87Genital tract atresia (HP:0001827)2.04183155
88Anteriorly placed anus (HP:0001545)2.03254860
89Hemiparesis (HP:0001269)2.02790415
90Abnormal eating behavior (HP:0100738)2.02667602
91Fetal akinesia sequence (HP:0001989)2.02015884
92Hypoplasia of the corpus callosum (HP:0002079)2.01606818
93Decreased lacrimation (HP:0000633)2.01261086
94Anxiety (HP:0000739)2.00481834
95Tetraplegia (HP:0002445)1.99637577
96Absent speech (HP:0001344)1.99357375
97Gait imbalance (HP:0002141)1.96223725
98Autoamputation (HP:0001218)1.95784704
99Insomnia (HP:0100785)1.95158385
100Absent septum pellucidum (HP:0001331)1.94296867
101Impaired social interactions (HP:0000735)1.92631388
102Abnormal social behavior (HP:0012433)1.92631388
103Bowel incontinence (HP:0002607)1.92425328
104Bradykinesia (HP:0002067)1.91243197
105Synostosis involving the elbow (HP:0003938)1.91182666
106Humeroradial synostosis (HP:0003041)1.91182666
107Dynein arm defect of respiratory motile cilia (HP:0012255)1.91064323
108Absent/shortened dynein arms (HP:0200106)1.91064323
109Agitation (HP:0000713)1.90759327
110Impaired vibration sensation in the lower limbs (HP:0002166)1.90754289
111Acute necrotizing encephalopathy (HP:0006965)1.90681132
112Morphological abnormality of the pyramidal tract (HP:0002062)1.89145913
113CNS hypomyelination (HP:0003429)1.88495036
114Clonus (HP:0002169)1.83741845
115Spastic paraparesis (HP:0002313)1.82595304
116Stereotypic behavior (HP:0000733)1.81567545
117Drooling (HP:0002307)1.81525318
118Excessive salivation (HP:0003781)1.81525318
119Neuronal loss in central nervous system (HP:0002529)1.81012540
120Poor speech (HP:0002465)1.79813723
121Apathy (HP:0000741)1.79741110
122Incomplete penetrance (HP:0003829)1.79081527
123Abnormality of binocular vision (HP:0011514)1.78850487
124Diplopia (HP:0000651)1.78850487
125Impaired vibratory sensation (HP:0002495)1.78749414
126Medial flaring of the eyebrow (HP:0010747)1.77921166
127Abnormal large intestine physiology (HP:0012700)1.77625069
128Bronchomalacia (HP:0002780)1.76749094
129Hypoplastic pelvis (HP:0008839)1.76695649
130Type II lissencephaly (HP:0007260)1.76489008
131Metabolic alkalosis (HP:0200114)1.76141704
132Morphological abnormality of the inner ear (HP:0011390)1.75645844
133Partial agenesis of the corpus callosum (HP:0001338)1.75384396
134Blue irides (HP:0000635)1.75224072
135Delusions (HP:0000746)1.75095950
136Congenital ichthyosiform erythroderma (HP:0007431)1.74630917
137Congenital primary aphakia (HP:0007707)1.74280107
138Steppage gait (HP:0003376)1.72932241
139Abnormality of salivation (HP:0100755)1.70551644
140Failure to thrive in infancy (HP:0001531)1.70431140
141Paraplegia (HP:0010550)1.68054077
142Lissencephaly (HP:0001339)1.67905758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.67170233
2OXSR13.75037125
3CASK2.93070098
4EPHA42.83829264
5TNIK2.65026456
6CDK192.62934042
7PNCK2.45847977
8NTRK32.24305338
9BCR2.15026532
10NTRK12.09090350
11MARK11.98763253
12PKN11.93142917
13WNK41.82438896
14PAK61.79306924
15PRPF4B1.78668834
16EPHB11.74223916
17UHMK11.73861127
18MAP3K91.72574412
19CAMKK11.71741508
20MAPKAPK51.65374348
21SIK21.60924057
22MAP3K41.55402482
23PINK11.52491690
24WNK11.50181280
25CAMK2B1.47547213
26FGFR21.47344984
27NEK61.43665457
28CSNK1G31.43280616
29NTRK21.38203045
30FGR1.37541462
31ARAF1.36706835
32MAP2K71.36061634
33MINK11.32437359
34CSNK1G21.30754974
35LIMK11.28732135
36CDK51.27747175
37ROCK21.27361561
38CSNK1A1L1.23023912
39CAMKK21.20556158
40MAPK131.19849853
41ICK1.18896272
42SGK2231.16292699
43SGK4941.16292699
44CAMK2D1.14960208
45TYRO31.14954675
46SGK21.13120409
47MET1.12909110
48KSR21.11650447
49CAMK2A1.11391625
50PBK1.10048098
51CSNK1G11.04524494
52CDK141.01132702
53PHKG21.00197132
54PHKG11.00197132
55LATS20.99858902
56GRK50.97711296
57FES0.97135063
58PAK30.96611731
59PLK20.93772256
60CDK150.91783804
61DAPK20.91232634
62CDK180.90491675
63CAMK2G0.90430344
64MUSK0.90238095
65EPHA30.85265567
66MAP3K130.82363721
67RIPK40.81946619
68CDK11A0.81728826
69MARK20.77853570
70PRKCE0.76832199
71MAP2K40.75123703
72EPHB20.73370312
73MAP3K120.71756870
74CLK10.70009728
75PRKCG0.69791272
76NME10.68267066
77DYRK20.66291784
78SGK30.65772366
79PRKCQ0.65094499
80BMPR20.64896504
81GRK70.63014320
82STK110.61919037
83KSR10.61675548
84PRKCZ0.60102289
85PTK2B0.59573165
86IRAK20.58068566
87PDPK10.57358070
88FYN0.57335849
89ADRBK20.57009952
90MAP4K20.56885270
91DYRK1A0.56488374
92DAPK10.56240609
93ERBB20.53789391
94CAMK40.53773306
95MST40.53518619
96TESK20.52440519
97RIPK10.51364777
98BMPR1B0.49526137
99RPS6KA30.49501059
100ERBB40.49079655
101ALK0.48696502
102CAMK1G0.47185527
103MAP3K20.45974754
104PRKCH0.45833223
105PRKG10.45175001
106ROCK10.42568729
107DYRK1B0.42344842
108RET0.42002751
109SGK10.40347057
110CSNK1A10.38962604
111PRKD30.38936321
112STK380.38845413
113PRKACA0.37950055
114PRKD10.36842572
115MAPK120.36169061
116WNK30.35401334
117MAPK100.35005607
118MAPK150.34134209
119PRKACB0.33513877
120PDK10.33385113
121CAMK10.32678303
122CDK30.32173620
123CSNK1D0.30894044
124CSNK1E0.29464654
125PRKCA0.28891411
126ERBB30.27711113
127PRKDC0.25885553
128PRKCB0.25407025

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.29323159
2Nicotine addiction_Homo sapiens_hsa050332.93486559
3Steroid biosynthesis_Homo sapiens_hsa001002.51861497
4Fatty acid elongation_Homo sapiens_hsa000622.48652822
5GABAergic synapse_Homo sapiens_hsa047272.41603430
6Synaptic vesicle cycle_Homo sapiens_hsa047212.39026287
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34705512
8Glutamatergic synapse_Homo sapiens_hsa047242.33546901
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31892914
10Oxidative phosphorylation_Homo sapiens_hsa001902.18689027
11Morphine addiction_Homo sapiens_hsa050322.13797182
12Collecting duct acid secretion_Homo sapiens_hsa049661.98659231
13Serotonergic synapse_Homo sapiens_hsa047261.98382307
14Ether lipid metabolism_Homo sapiens_hsa005651.96277973
15Circadian entrainment_Homo sapiens_hsa047131.93447567
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89171489
17Axon guidance_Homo sapiens_hsa043601.87582017
18Long-term depression_Homo sapiens_hsa047301.73769817
19Olfactory transduction_Homo sapiens_hsa047401.71700880
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70034174
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68498376
22Salivary secretion_Homo sapiens_hsa049701.67779464
23Dopaminergic synapse_Homo sapiens_hsa047281.67645003
24Long-term potentiation_Homo sapiens_hsa047201.65829078
25Amphetamine addiction_Homo sapiens_hsa050311.65314571
26Alzheimers disease_Homo sapiens_hsa050101.59255802
27Parkinsons disease_Homo sapiens_hsa050121.55757494
28Taste transduction_Homo sapiens_hsa047421.51958049
29Cocaine addiction_Homo sapiens_hsa050301.44934470
30Cholinergic synapse_Homo sapiens_hsa047251.41751660
31Vibrio cholerae infection_Homo sapiens_hsa051101.40947475
32Gastric acid secretion_Homo sapiens_hsa049711.35744354
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35076557
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33963522
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29960507
36Cardiac muscle contraction_Homo sapiens_hsa042601.29044109
37Renin secretion_Homo sapiens_hsa049241.27171990
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23793605
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19463539
40Phototransduction_Homo sapiens_hsa047441.16493920
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16101606
42Insulin secretion_Homo sapiens_hsa049111.15680882
43Sphingolipid metabolism_Homo sapiens_hsa006001.13197641
44Calcium signaling pathway_Homo sapiens_hsa040201.10774295
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07781474
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04632755
47Oxytocin signaling pathway_Homo sapiens_hsa049211.01902288
48Gap junction_Homo sapiens_hsa045401.01796751
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00431976
50Butanoate metabolism_Homo sapiens_hsa006500.96734696
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.93680979
52ErbB signaling pathway_Homo sapiens_hsa040120.90878604
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89014250
54Sulfur metabolism_Homo sapiens_hsa009200.88959460
55Huntingtons disease_Homo sapiens_hsa050160.88830580
56cAMP signaling pathway_Homo sapiens_hsa040240.86936089
57Type II diabetes mellitus_Homo sapiens_hsa049300.83904192
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83823383
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.83734553
60Renal cell carcinoma_Homo sapiens_hsa052110.83708748
61Bile secretion_Homo sapiens_hsa049760.83695627
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.83497378
63GnRH signaling pathway_Homo sapiens_hsa049120.81959278
64Dorso-ventral axis formation_Homo sapiens_hsa043200.80703473
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78592224
66Rheumatoid arthritis_Homo sapiens_hsa053230.77816589
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77528513
68Pancreatic secretion_Homo sapiens_hsa049720.77505468
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77222083
70Ras signaling pathway_Homo sapiens_hsa040140.73827924
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73753389
72Melanogenesis_Homo sapiens_hsa049160.73451724
73Vitamin B6 metabolism_Homo sapiens_hsa007500.73316120
74Circadian rhythm_Homo sapiens_hsa047100.72794359
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72648507
76Oocyte meiosis_Homo sapiens_hsa041140.70816812
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69509377
78Protein export_Homo sapiens_hsa030600.66867169
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.65971013
80Linoleic acid metabolism_Homo sapiens_hsa005910.65439709
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60736120
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59635353
83Choline metabolism in cancer_Homo sapiens_hsa052310.59585018
84Tight junction_Homo sapiens_hsa045300.58386275
85Endocytosis_Homo sapiens_hsa041440.58329887
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57959803
87Hippo signaling pathway_Homo sapiens_hsa043900.55984654
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55780503
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55662473
90Ovarian steroidogenesis_Homo sapiens_hsa049130.55618765
91Estrogen signaling pathway_Homo sapiens_hsa049150.55039747
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.53955138
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53157248
94MAPK signaling pathway_Homo sapiens_hsa040100.50672242
95Alcoholism_Homo sapiens_hsa050340.48647039
96Hedgehog signaling pathway_Homo sapiens_hsa043400.45734159
97Phagosome_Homo sapiens_hsa041450.45094939
98Histidine metabolism_Homo sapiens_hsa003400.44527986
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44289277
100Inositol phosphate metabolism_Homo sapiens_hsa005620.40952216
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40454980
102Thyroid hormone synthesis_Homo sapiens_hsa049180.40069428
103Prion diseases_Homo sapiens_hsa050200.39328362
104Wnt signaling pathway_Homo sapiens_hsa043100.38766687
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38297938
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37805543
107Nitrogen metabolism_Homo sapiens_hsa009100.37784955
108Mineral absorption_Homo sapiens_hsa049780.36996774
109beta-Alanine metabolism_Homo sapiens_hsa004100.36968684
110Glucagon signaling pathway_Homo sapiens_hsa049220.35330148
111Dilated cardiomyopathy_Homo sapiens_hsa054140.33774702
112VEGF signaling pathway_Homo sapiens_hsa043700.33472604
113Glioma_Homo sapiens_hsa052140.32546678
114Regulation of autophagy_Homo sapiens_hsa041400.31684661
115Fatty acid biosynthesis_Homo sapiens_hsa000610.31331042
116Endometrial cancer_Homo sapiens_hsa052130.30768252
117Arginine and proline metabolism_Homo sapiens_hsa003300.30007129
118Rap1 signaling pathway_Homo sapiens_hsa040150.29892119
119Autoimmune thyroid disease_Homo sapiens_hsa053200.29524735
120Basal cell carcinoma_Homo sapiens_hsa052170.28911827
121AMPK signaling pathway_Homo sapiens_hsa041520.24794249
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24132385
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23341198

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