SYT12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.19844995
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.14093126
3regulation of cell proliferation involved in kidney development (GO:1901722)5.12440943
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10205718
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.07126880
6locomotory exploration behavior (GO:0035641)4.91532939
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.86257561
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.83385681
9neuronal action potential propagation (GO:0019227)4.78835517
10behavioral response to nicotine (GO:0035095)4.64694444
11glutamate receptor signaling pathway (GO:0007215)4.55383488
12synaptic vesicle exocytosis (GO:0016079)4.54396024
13regulation of glutamate receptor signaling pathway (GO:1900449)4.53365664
14synaptic vesicle maturation (GO:0016188)4.51689075
15cellular potassium ion homeostasis (GO:0030007)4.51535245
16glutamate secretion (GO:0014047)4.50640803
17synaptic transmission, glutamatergic (GO:0035249)4.44390798
18cerebellar granule cell differentiation (GO:0021707)4.34318345
19regulation of synaptic vesicle exocytosis (GO:2000300)4.33072807
20response to lipoprotein particle (GO:0055094)4.32463090
21neurotransmitter-gated ion channel clustering (GO:0072578)4.32044126
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.30540824
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.23564692
24neuron-neuron synaptic transmission (GO:0007270)4.16725080
25neurotransmitter secretion (GO:0007269)4.13880938
26branching involved in labyrinthine layer morphogenesis (GO:0060670)4.08088207
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.07870821
28regulation of synaptic vesicle transport (GO:1902803)4.01733877
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00399119
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00101934
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95972903
32positive regulation of fatty acid oxidation (GO:0046321)3.90083066
33gamma-aminobutyric acid transport (GO:0015812)3.89300555
34protein localization to synapse (GO:0035418)3.85791101
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.79097674
36regulation of neuronal synaptic plasticity (GO:0048168)3.74223868
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71926352
38cerebellar Purkinje cell differentiation (GO:0021702)3.66731179
39long-term memory (GO:0007616)3.66573973
40positive regulation of synapse maturation (GO:0090129)3.66046470
41exploration behavior (GO:0035640)3.64344636
42neuron cell-cell adhesion (GO:0007158)3.64019085
43purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.59709593
443-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.59709593
45proline transport (GO:0015824)3.59661783
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59421189
47long-term synaptic potentiation (GO:0060291)3.55272790
48serotonin metabolic process (GO:0042428)3.54421416
49regulation of glomerulus development (GO:0090192)3.49587738
50regulation of postsynaptic membrane potential (GO:0060078)3.48112457
51response to parathyroid hormone (GO:0071107)3.46431109
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.45999021
53sodium ion export (GO:0071436)3.42985979
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41445939
55regulation of hippo signaling (GO:0035330)3.36439273
56regulation of synaptic plasticity (GO:0048167)3.36318117
57cell communication by electrical coupling (GO:0010644)3.34249711
58neurotransmitter transport (GO:0006836)3.32024365
59presynaptic membrane assembly (GO:0097105)3.31463891
60postsynaptic membrane organization (GO:0001941)3.31193984
61positive regulation of membrane potential (GO:0045838)3.31185593
62glycine transport (GO:0015816)3.30408154
63presynaptic membrane organization (GO:0097090)3.29900408
64regulation of neurotransmitter secretion (GO:0046928)3.27943143
65primary amino compound metabolic process (GO:1901160)3.26374160
66cellular response to ATP (GO:0071318)3.25126138
67regulation of synapse maturation (GO:0090128)3.25122970
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24734989
69activation of protein kinase A activity (GO:0034199)3.24684604
70synaptic vesicle endocytosis (GO:0048488)3.23968604
71regulation of synapse structural plasticity (GO:0051823)3.23567373
72long term synaptic depression (GO:0060292)3.23152215
73transmission of nerve impulse (GO:0019226)3.20306599
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16906267
75membrane depolarization (GO:0051899)3.16243223
76membrane depolarization during action potential (GO:0086010)3.16118086
77cellular anion homeostasis (GO:0030002)3.15557352
78sulfation (GO:0051923)3.11296156
79regulation of neurotransmitter levels (GO:0001505)3.10630774
80regulation of neurotransmitter transport (GO:0051588)3.08447153
81membrane hyperpolarization (GO:0060081)3.06811029
82auditory behavior (GO:0031223)3.06270337
83prostate gland growth (GO:0060736)3.04978200
84negative regulation of kidney development (GO:0090185)3.03044930
85neuromuscular synaptic transmission (GO:0007274)3.02495399
86response to auditory stimulus (GO:0010996)3.01696748
87cell differentiation in hindbrain (GO:0021533)3.01205968
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00587317
89prepulse inhibition (GO:0060134)3.00272244
90neuromuscular process controlling balance (GO:0050885)2.97596897
91regulation of vesicle fusion (GO:0031338)2.96848765
92regulation of voltage-gated calcium channel activity (GO:1901385)2.96835355
93L-amino acid import (GO:0043092)2.96832611
94negative regulation of dendrite morphogenesis (GO:0050774)2.94490538
95peristalsis (GO:0030432)2.94385934
96positive regulation of neurotransmitter secretion (GO:0001956)2.93668262
97learning (GO:0007612)2.92499177
98alanine transport (GO:0032328)2.91978171
99positive regulation of synaptic transmission (GO:0050806)2.91207105
100negative regulation of amino acid transport (GO:0051956)2.90405552
101regulation of calcium ion-dependent exocytosis (GO:0017158)2.90108018
102regulation of synaptic transmission (GO:0050804)2.88067901
103neuromuscular process controlling posture (GO:0050884)2.87812809
104response to histamine (GO:0034776)2.87542390
105cellular sodium ion homeostasis (GO:0006883)2.86112123
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85621838
107regulation of dendritic spine morphogenesis (GO:0061001)2.84266481
108positive regulation of neurotransmitter transport (GO:0051590)2.83213246
109potassium ion homeostasis (GO:0055075)2.79714671
110synaptic transmission (GO:0007268)2.79537630
111phosphate ion homeostasis (GO:0055062)2.78913610
112trivalent inorganic anion homeostasis (GO:0072506)2.78913610
113potassium ion import (GO:0010107)2.78333850
114cornea development in camera-type eye (GO:0061303)2.78145726
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78056771
116flavonoid metabolic process (GO:0009812)2.77009226
117mechanosensory behavior (GO:0007638)2.75913747
118adult walking behavior (GO:0007628)2.75815029
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75443200
120negative regulation of dendrite development (GO:2000171)2.75111669
121neuron recognition (GO:0008038)2.74379540
122synapse assembly (GO:0007416)2.74370242
123regulation of phospholipid biosynthetic process (GO:0071071)2.74290619
124dendritic spine morphogenesis (GO:0060997)2.73678939
125mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71554966
126mitochondrial respiratory chain complex I assembly (GO:0032981)2.71554966
127NADH dehydrogenase complex assembly (GO:0010257)2.71554966
128neuronal action potential (GO:0019228)2.71147602
129cell proliferation in forebrain (GO:0021846)2.70300428
130positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70124196
131axonal fasciculation (GO:0007413)2.70032693
132mesonephros development (GO:0001823)2.69995022
133indole-containing compound metabolic process (GO:0042430)2.69436486
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.69121201
135negative regulation of telomerase activity (GO:0051974)2.64157482
136white fat cell differentiation (GO:0050872)2.60936588
137chemosensory behavior (GO:0007635)2.60477140
138kynurenine metabolic process (GO:0070189)2.58121189
139positive regulation of triglyceride biosynthetic process (GO:0010867)2.56528649
140membrane repolarization during action potential (GO:0086011)2.56053269
141DNA deamination (GO:0045006)2.55458317
142positive regulation of fatty acid beta-oxidation (GO:0032000)2.54015559
143branching involved in salivary gland morphogenesis (GO:0060445)2.54014970
144regulation of female receptivity (GO:0045924)2.52357324
145action potential (GO:0001508)2.50502029
146serine family amino acid catabolic process (GO:0009071)2.50456220
147mitochondrion morphogenesis (GO:0070584)2.50334953
148regulation of sodium ion transmembrane transporter activity (GO:2000649)2.49138772
149startle response (GO:0001964)2.47990030
150spinal cord development (GO:0021510)2.47028101
151pharyngeal system development (GO:0060037)2.45643806
152indole-containing compound catabolic process (GO:0042436)2.43627048
153indolalkylamine catabolic process (GO:0046218)2.43627048
154tryptophan catabolic process (GO:0006569)2.43627048
155cell differentiation involved in embryonic placenta development (GO:0060706)2.43572704
156regulation of action potential (GO:0098900)2.42238301
157multicellular organismal signaling (GO:0035637)2.40352744
158water-soluble vitamin biosynthetic process (GO:0042364)2.40021297
159positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.38901117
160adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.37806410
161regulation of neurotransmitter uptake (GO:0051580)2.36035098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99149413
2GBX2_23144817_ChIP-Seq_PC3_Human3.85145474
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.76064112
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.20331306
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07719462
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04517670
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77408983
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.68427717
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64339207
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64339207
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56639983
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55087254
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48122550
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46506918
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38848006
16DROSHA_22980978_ChIP-Seq_HELA_Human2.37789047
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32167832
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30919766
19REST_21632747_ChIP-Seq_MESCs_Mouse2.28885683
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.27867520
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24247768
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.21021843
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.08881962
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.03723903
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.99639036
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98562631
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97193525
28TDRD3_21172665_ChIP-Seq_MCF-7_Human1.83846334
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82532929
30AR_21572438_ChIP-Seq_LNCaP_Human1.82164208
31TAF15_26573619_Chip-Seq_HEK293_Human1.79321789
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.75906639
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.73944952
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72514954
35SMAD4_21799915_ChIP-Seq_A2780_Human1.72197204
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69728330
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69051577
38* ESR1_20079471_ChIP-ChIP_T-47D_Human1.63903157
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62613710
40ZNF274_21170338_ChIP-Seq_K562_Hela1.61017174
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57654193
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57118619
43P300_19829295_ChIP-Seq_ESCs_Human1.54024845
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53501487
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53285686
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52462590
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48915969
48* AR_25329375_ChIP-Seq_VCAP_Human1.41254188
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.40836955
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.40285907
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.40053836
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39912544
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39630668
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38888626
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35379712
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34063983
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32677349
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31959418
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.31374015
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30894197
61* STAT3_23295773_ChIP-Seq_U87_Human1.29198795
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25427247
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23256451
64RXR_22108803_ChIP-Seq_LS180_Human1.22297633
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21751616
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20964872
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.20623644
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19916089
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19816143
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19702129
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18564111
72AR_19668381_ChIP-Seq_PC3_Human1.18022513
73* AHR_22903824_ChIP-Seq_MCF-7_Human1.17701323
74* ERA_21632823_ChIP-Seq_H3396_Human1.15892389
75TP53_18474530_ChIP-ChIP_U2OS_Human1.15888968
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15773198
77* CBX2_27304074_Chip-Seq_ESCs_Mouse1.15700033
78* RUNX1_27514584_Chip-Seq_MCF-7_Human1.15450455
79* CTCF_27219007_Chip-Seq_Bcells_Human1.14250098
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13708244
81TP53_16413492_ChIP-PET_HCT116_Human1.13551027
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13192226
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12849309
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12266715
85* TCF4_23295773_ChIP-Seq_U87_Human1.10643965
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.08988629
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.08813671
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08314170
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08070149
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06430055
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05577788
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.04951145
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.04945161
94* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03835046
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03360583
96RNF2_27304074_Chip-Seq_NSC_Mouse1.02326099
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01607720
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00589131
99BCAT_22108803_ChIP-Seq_LS180_Human1.00096203
100P53_22387025_ChIP-Seq_ESCs_Mouse0.99243677
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98805631
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98204576
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97559111
104* P68_20966046_ChIP-Seq_HELA_Human0.97262851
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96969123
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.96599041
107* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96431108
108HOXB7_26014856_ChIP-Seq_BT474_Human0.95804735
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95793984
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95793984
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.95087317
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.95074040
113ER_23166858_ChIP-Seq_MCF-7_Human0.94569280
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.94000646
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.93596902
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93585585
117SMC4_20622854_ChIP-Seq_HELA_Human0.93221792
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.93046091
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92606690
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.92568821
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92512919
122CMYC_18555785_Chip-Seq_ESCs_Mouse0.92352347
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91735729
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91030207
125IGF1R_20145208_ChIP-Seq_DFB_Human0.90467686
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90392277
127TP53_22573176_ChIP-Seq_HFKS_Human0.89440368
128GATA3_21878914_ChIP-Seq_MCF-7_Human0.87050107
129PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86734367
130* GATA3_24758297_ChIP-Seq_MCF-7_Human0.86697339
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86252371
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85288713
133RAC3_21632823_ChIP-Seq_H3396_Human0.81187865
134OCT4_19829295_ChIP-Seq_ESCs_Human0.79749587
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78392506
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77750950
137* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76259866
138E2F1_20622854_ChIP-Seq_HELA_Human0.76239162
139* CTCF_20526341_ChIP-Seq_ESCs_Human0.75281144
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.75107466
141FUS_26573619_Chip-Seq_HEK293_Human0.73985649
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71749040
143MYC_18940864_ChIP-ChIP_HL60_Human0.71074860
144NCOR_22424771_ChIP-Seq_293T_Human0.70304075
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.70269147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77375359
2MP0003880_abnormal_central_pattern4.11067633
3MP0003635_abnormal_synaptic_transmissio3.92886993
4MP0009046_muscle_twitch3.73152196
5MP0009745_abnormal_behavioral_response3.50757207
6MP0000678_abnormal_parathyroid_gland3.47033942
7MP0002063_abnormal_learning/memory/cond3.18413660
8MP0002064_seizures3.01932397
9MP0004270_analgesia2.99917735
10MP0001968_abnormal_touch/_nociception2.90934387
11MP0001501_abnormal_sleep_pattern2.80603014
12MP0002572_abnormal_emotion/affect_behav2.78283343
13MP0002272_abnormal_nervous_system2.67078503
14MP0001486_abnormal_startle_reflex2.66858492
15MP0002736_abnormal_nociception_after2.59054895
16MP0002734_abnormal_mechanical_nocicepti2.37024164
17MP0002822_catalepsy2.36266713
18MP0008569_lethality_at_weaning2.27720994
19MP0001440_abnormal_grooming_behavior2.27678918
20MP0003195_calcinosis2.24998697
21MP0002735_abnormal_chemical_nociception2.22376363
22MP0005423_abnormal_somatic_nervous2.19187136
23MP0005646_abnormal_pituitary_gland2.17566537
24MP0002067_abnormal_sensory_capabilities2.14259495
25MP0002876_abnormal_thyroid_physiology2.03601278
26MP0009780_abnormal_chondrocyte_physiolo1.91657375
27MP0001188_hyperpigmentation1.89273078
28MP0002653_abnormal_ependyma_morphology1.86965449
29MP0005386_behavior/neurological_phenoty1.74447613
30MP0004924_abnormal_behavior1.74447613
31MP0001970_abnormal_pain_threshold1.72972014
32MP0002557_abnormal_social/conspecific_i1.68950368
33MP0006292_abnormal_olfactory_placode1.68246677
34MP0002733_abnormal_thermal_nociception1.67545336
35MP0003879_abnormal_hair_cell1.66821215
36MP0002160_abnormal_reproductive_system1.66207261
37MP0002184_abnormal_innervation1.65618024
38MP0000516_abnormal_urinary_system1.63307775
39MP0005367_renal/urinary_system_phenotyp1.63307775
40MP0001984_abnormal_olfaction1.61022845
41MP0000383_abnormal_hair_follicle1.58176673
42MP0000049_abnormal_middle_ear1.55214411
43MP0003690_abnormal_glial_cell1.52738042
44MP0004858_abnormal_nervous_system1.52351561
45MP0005171_absent_coat_pigmentation1.52195127
46MP0005645_abnormal_hypothalamus_physiol1.49409325
47MP0000778_abnormal_nervous_system1.41725416
48MP0002909_abnormal_adrenal_gland1.41598908
49MP0008872_abnormal_physiological_respon1.40655027
50MP0003633_abnormal_nervous_system1.40548861
51MP0006276_abnormal_autonomic_nervous1.39507718
52MP0000013_abnormal_adipose_tissue1.38237908
53MP0002249_abnormal_larynx_morphology1.37518296
54MP0001502_abnormal_circadian_rhythm1.35894871
55MP0001177_atelectasis1.33547919
56MP0002066_abnormal_motor_capabilities/c1.32543732
57MP0004147_increased_porphyrin_level1.28252109
58MP0004811_abnormal_neuron_physiology1.27161687
59MP0003787_abnormal_imprinting1.26318428
60MP0008877_abnormal_DNA_methylation1.25368790
61MP0004145_abnormal_muscle_electrophysio1.22810408
62MP0005535_abnormal_body_temperature1.22527726
63MP0008875_abnormal_xenobiotic_pharmacok1.20434314
64MP0004142_abnormal_muscle_tone1.20177276
65MP0001348_abnormal_lacrimal_gland1.19467303
66MP0003123_paternal_imprinting1.19346591
67MP0003631_nervous_system_phenotype1.18069590
68MP0003329_amyloid_beta_deposits1.17827531
69MP0005670_abnormal_white_adipose1.15679054
70MP0002882_abnormal_neuron_morphology1.12315435
71MP0000955_abnormal_spinal_cord1.11307254
72MP0004885_abnormal_endolymph1.11117264
73MP0004742_abnormal_vestibular_system1.09849116
74MP0003938_abnormal_ear_development1.08631460
75MP0010678_abnormal_skin_adnexa1.07452881
76MP0004133_heterotaxia1.06491272
77MP0000427_abnormal_hair_cycle1.05608498
78MP0003638_abnormal_response/metabolism_1.03936025
79MP0009250_abnormal_appendicular_skeleto1.02924759
80MP0002837_dystrophic_cardiac_calcinosis1.02786283
81MP0001765_abnormal_ion_homeostasis1.02451320
82MP0005083_abnormal_biliary_tract1.00503711
83MP0002069_abnormal_eating/drinking_beha0.97404425
84MP0001529_abnormal_vocalization0.97127775
85MP0001963_abnormal_hearing_physiology0.96910270
86MP0002938_white_spotting0.96686004
87MP0004484_altered_response_of0.95828949
88MP0005389_reproductive_system_phenotype0.95443816
89MP0002098_abnormal_vibrissa_morphology0.94356469
90MP0010386_abnormal_urinary_bladder0.92488485
91MP0008874_decreased_physiological_sensi0.92239139
92MP0005394_taste/olfaction_phenotype0.92073914
93MP0005499_abnormal_olfactory_system0.92073914
94MP0005167_abnormal_blood-brain_barrier0.91561812
95MP0004381_abnormal_hair_follicle0.90599630
96MP0003119_abnormal_digestive_system0.88299589
97MP0000751_myopathy0.88182798
98MP0003646_muscle_fatigue0.87275120
99MP0002138_abnormal_hepatobiliary_system0.86469293
100MP0004130_abnormal_muscle_cell0.86188888
101MP0005174_abnormal_tail_pigmentation0.85945995
102MP0001905_abnormal_dopamine_level0.85703004
103MP0004215_abnormal_myocardial_fiber0.84686797
104MP0002152_abnormal_brain_morphology0.84241079
105MP0003936_abnormal_reproductive_system0.82750501
106MP0003632_abnormal_nervous_system0.82239331
107MP0009053_abnormal_anal_canal0.81921197
108MP0003075_altered_response_to0.81013322
109MP0003942_abnormal_urinary_system0.80987581
110MP0002751_abnormal_autonomic_nervous0.78670946
111MP0004043_abnormal_pH_regulation0.77736326
112MP0004085_abnormal_heartbeat0.77464240
113MP0002638_abnormal_pupillary_reflex0.77289768
114MP0002229_neurodegeneration0.76712551
115MP0000579_abnormal_nail_morphology0.74304674
116MP0003136_yellow_coat_color0.74188895
117MP0001986_abnormal_taste_sensitivity0.73120741
118MP0001664_abnormal_digestion0.73030595
119MP0000003_abnormal_adipose_tissue0.72677198
120MP0005195_abnormal_posterior_eye0.72630722
121MP0006072_abnormal_retinal_apoptosis0.70899240
122MP0003937_abnormal_limbs/digits/tail_de0.70750180
123MP0005551_abnormal_eye_electrophysiolog0.70534422
124MP0003045_fibrosis0.70241268
125MP0005409_darkened_coat_color0.66443693
126MP0010329_abnormal_lipoprotein_level0.62536309
127MP0003137_abnormal_impulse_conducting0.62297159
128MP0000026_abnormal_inner_ear0.59322884
129MP0005620_abnormal_muscle_contractility0.59123340
130MP0003183_abnormal_peptide_metabolism0.58378297
131MP0005595_abnormal_vascular_smooth0.58349991
132MP0002752_abnormal_somatic_nervous0.57281915
133MP0005448_abnormal_energy_balance0.56301515
134MP0001485_abnormal_pinna_reflex0.55358865
135MP0006138_congestive_heart_failure0.55335910
136MP0000631_abnormal_neuroendocrine_gland0.55197416
137MP0002971_abnormal_brown_adipose0.52539323
138MP0000920_abnormal_myelination0.52255242
139MP0005666_abnormal_adipose_tissue0.50086816

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.73351593
2Myokymia (HP:0002411)6.16279302
3Febrile seizures (HP:0002373)6.06373285
4Focal seizures (HP:0007359)5.97486655
5Epileptic encephalopathy (HP:0200134)5.49507355
6Progressive cerebellar ataxia (HP:0002073)5.24847876
7Atonic seizures (HP:0010819)5.12192827
8Action tremor (HP:0002345)4.98181042
9Visual hallucinations (HP:0002367)4.39943334
10Gaze-evoked nystagmus (HP:0000640)4.37463747
11Absence seizures (HP:0002121)4.36481394
12Generalized tonic-clonic seizures (HP:0002069)4.18375116
13Short 1st metacarpal (HP:0010034)4.07637231
14Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.07637231
15Broad-based gait (HP:0002136)4.01777356
16Hyperventilation (HP:0002883)3.96130602
17Hyperphosphatemia (HP:0002905)3.88415804
18Dialeptic seizures (HP:0011146)3.84639444
19Dysdiadochokinesis (HP:0002075)3.83783078
20Poor eye contact (HP:0000817)3.64420702
21Pendular nystagmus (HP:0012043)3.60660805
22Tetany (HP:0001281)3.57967689
23Dysmetric saccades (HP:0000641)3.54636511
24Scanning speech (HP:0002168)3.51399691
25Abnormality of the 1st metacarpal (HP:0010009)3.48244088
26Abnormal eating behavior (HP:0100738)3.33649697
27Impaired social interactions (HP:0000735)3.21174439
28Abnormal social behavior (HP:0012433)3.21174439
29Impaired smooth pursuit (HP:0007772)3.18824667
30Fetal akinesia sequence (HP:0001989)3.15137845
31Dysmetria (HP:0001310)3.03565101
32J-shaped sella turcica (HP:0002680)3.02936792
33Aplasia involving bones of the extremities (HP:0009825)3.02464762
34Aplasia involving bones of the upper limbs (HP:0009823)3.02464762
35Aplasia of the phalanges of the hand (HP:0009802)3.02464762
36Hemiplegia (HP:0002301)3.01814560
37Anxiety (HP:0000739)2.99234366
38Stenosis of the external auditory canal (HP:0000402)2.94360900
39Truncal ataxia (HP:0002078)2.91899309
40Concave nail (HP:0001598)2.91422695
41Status epilepticus (HP:0002133)2.87595882
42Absent thumb (HP:0009777)2.87400604
43Impaired vibration sensation in the lower limbs (HP:0002166)2.86776955
44Postural instability (HP:0002172)2.80541913
45Amblyopia (HP:0000646)2.80483984
46Abnormality of ocular smooth pursuit (HP:0000617)2.80273996
47Type II lissencephaly (HP:0007260)2.77546344
48Hemiparesis (HP:0001269)2.74198043
49Depression (HP:0000716)2.72645330
50Severe muscular hypotonia (HP:0006829)2.69900339
51Blue irides (HP:0000635)2.67138684
52Short phalanx of the thumb (HP:0009660)2.66062350
53Abnormality of the nasal septum (HP:0000419)2.59550632
54Intention tremor (HP:0002080)2.58607132
55Carpal bone hypoplasia (HP:0001498)2.57888849
56Congenital stationary night blindness (HP:0007642)2.56835175
57Tachypnea (HP:0002789)2.54996207
58Fused cervical vertebrae (HP:0002949)2.54590616
59Cerebellar dysplasia (HP:0007033)2.51649737
60Urinary bladder sphincter dysfunction (HP:0002839)2.50631106
61Genetic anticipation (HP:0003743)2.50179476
62Ectopic kidney (HP:0000086)2.49542484
63Short hallux (HP:0010109)2.47572475
64Diplopia (HP:0000651)2.46450821
65Abnormality of binocular vision (HP:0011514)2.46450821
66Annular pancreas (HP:0001734)2.41556144
67Incomplete penetrance (HP:0003829)2.38207198
68Pancreatic cysts (HP:0001737)2.34835269
69Drooling (HP:0002307)2.34068356
70Excessive salivation (HP:0003781)2.34068356
71Increased corneal curvature (HP:0100692)2.33155294
72Keratoconus (HP:0000563)2.33155294
73Aplasia/Hypoplasia of the hallux (HP:0008362)2.31860920
74Absent speech (HP:0001344)2.31192441
75Microretrognathia (HP:0000308)2.30990678
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29263908
77Abnormality of alanine metabolism (HP:0010916)2.29263908
78Hyperalaninemia (HP:0003348)2.29263908
79Impaired vibratory sensation (HP:0002495)2.25896601
80Abnormality of DNA repair (HP:0003254)2.25229120
81Abnormality of the lower motor neuron (HP:0002366)2.24141656
82Abnormality of calcium-phosphate metabolism (HP:0100530)2.22377509
83Abnormality of the renal collecting system (HP:0004742)2.21435125
84Morphological abnormality of the middle ear (HP:0008609)2.20931454
85Chorioretinal atrophy (HP:0000533)2.20878387
86Supranuclear gaze palsy (HP:0000605)2.20550905
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20133624
88Bradykinesia (HP:0002067)2.17126612
89Abolished electroretinogram (ERG) (HP:0000550)2.17021253
90Abnormality of the carotid arteries (HP:0005344)2.16565225
91Stereotypic behavior (HP:0000733)2.16303699
92Epileptiform EEG discharges (HP:0011182)2.15017783
93Gait ataxia (HP:0002066)2.14981963
94Short thumb (HP:0009778)2.14879870
95Torticollis (HP:0000473)2.13848548
96Protruding tongue (HP:0010808)2.11813647
97Ventricular fibrillation (HP:0001663)2.10675390
98Agitation (HP:0000713)2.09949280
99Spinal canal stenosis (HP:0003416)2.09345078
100Akinesia (HP:0002304)2.06618645
101Bundle branch block (HP:0011710)2.06330677
102Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06263932
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06002618
104Abnormality of the proximal phalanges of the hand (HP:0009834)2.04548485
105Horizontal nystagmus (HP:0000666)2.04465629
106Focal dystonia (HP:0004373)2.04195224
107Abnormal EKG (HP:0003115)2.04176452
108Bony spicule pigmentary retinopathy (HP:0007737)2.04008700
109Oligomenorrhea (HP:0000876)2.03778818
110Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.03082113
111Lower limb asymmetry (HP:0100559)2.01538900
112Polydipsia (HP:0001959)2.01295883
113Abnormal drinking behavior (HP:0030082)2.01295883
114Fair hair (HP:0002286)2.00736289
115Hypocalcemia (HP:0002901)1.99696026
116Congenital sensorineural hearing impairment (HP:0008527)1.98416828
117Attenuation of retinal blood vessels (HP:0007843)1.95656994
118Generalized hypopigmentation of hair (HP:0011358)1.93644271
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93118468
120Pheochromocytoma (HP:0002666)1.92340512
121Narrow nasal bridge (HP:0000446)1.91900896
122Prolonged QT interval (HP:0001657)1.91318727
123Abnormality of saccadic eye movements (HP:0000570)1.90550917
124True hermaphroditism (HP:0010459)1.90384843
125Pancreatic fibrosis (HP:0100732)1.89726977
126Acute necrotizing encephalopathy (HP:0006965)1.88233969
127Hypoparathyroidism (HP:0000829)1.87786318
128Nephronophthisis (HP:0000090)1.87575457
129EEG with generalized epileptiform discharges (HP:0011198)1.87061650
130Cystic liver disease (HP:0006706)1.86894120
131Lower limb amyotrophy (HP:0007210)1.86568364
132Synostosis involving the elbow (HP:0003938)1.85410867
133Humeroradial synostosis (HP:0003041)1.85410867
134Synostosis of carpal bones (HP:0005048)1.84612748
135Limb ataxia (HP:0002070)1.84485643
136Duplicated collecting system (HP:0000081)1.83721656
137Abnormal mitochondria in muscle tissue (HP:0008316)1.82290614
138Abnormality of salivation (HP:0100755)1.82217195
139Abnormality of cochlea (HP:0000375)1.81705218
140Aqueductal stenosis (HP:0002410)1.81680184
141Long nose (HP:0003189)1.81434365
142Absent radius (HP:0003974)1.81221668
143Polyphagia (HP:0002591)1.80924176
144Urinary urgency (HP:0000012)1.80288119
145Syncope (HP:0001279)1.79119561
146Inability to walk (HP:0002540)1.78285840
147Horseshoe kidney (HP:0000085)1.75088611
148Resting tremor (HP:0002322)1.74971444
149Increased circulating renin level (HP:0000848)1.74765751
150Goiter (HP:0000853)1.74085388
151Hyperthyroidism (HP:0000836)1.73260364
152Aplasia involving forearm bones (HP:0009822)1.72872771
153Absent forearm bone (HP:0003953)1.72872771
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72198612
155Ankle clonus (HP:0011448)1.72160393
156Amelogenesis imperfecta (HP:0000705)1.71805278
157Deeply set eye (HP:0000490)1.71626647
158Pointed chin (HP:0000307)1.71152040
159Abnormality of midbrain morphology (HP:0002418)1.71030725
160Molar tooth sign on MRI (HP:0002419)1.71030725
161Abnormality of the middle phalanges of the toes (HP:0010183)1.70981062
162Psychosis (HP:0000709)1.70523907
163Oligodactyly (hands) (HP:0001180)1.69950948
164Confusion (HP:0001289)1.69380471
165Craniofacial dystonia (HP:0012179)1.68937630
166Menstrual irregularities (HP:0000858)1.68337202
167Rectal fistula (HP:0100590)1.68246874
168Rectovaginal fistula (HP:0000143)1.68246874
169Sleep apnea (HP:0010535)1.68132161
170Lower limb muscle weakness (HP:0007340)1.67859356
171Bradycardia (HP:0001662)1.67013392
172Progressive inability to walk (HP:0002505)1.66940709
173Aplasia/hypoplasia of the humerus (HP:0006507)1.66585585
174Spastic gait (HP:0002064)1.66073390
175Intellectual disability, moderate (HP:0002342)1.65073547
176Short humerus (HP:0005792)1.64843586
177Abnormality of the renal cortex (HP:0011035)1.64655938
178Abnormality of the corticospinal tract (HP:0002492)1.62959767
179Hypsarrhythmia (HP:0002521)1.61950827
180Postural tremor (HP:0002174)1.60191934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.31059170
2NTRK34.17892569
3CASK3.50977923
4MAP2K72.97877973
5GRK12.84019909
6DAPK22.80327614
7MAP3K42.71416083
8MAP3K122.62093367
9PRPF4B2.58144765
10RIPK42.43985380
11MAP3K92.35175092
12ADRBK22.29335480
13MINK12.28602130
14MAPKAPK32.21497801
15PINK12.10189755
16MAP2K41.95859465
17WNK41.80721713
18TLK11.79965036
19SGK21.78468680
20CAMKK21.75763846
21BMPR1B1.73968521
22PIK3CA1.68518049
23MAP2K21.68383956
24CAMKK11.66052005
25AKT31.64813890
26DAPK11.62276540
27EPHA21.61410439
28PRKD31.59351259
29NTRK21.59119939
30PLK21.58090398
31ZAK1.56545742
32CDK191.55118581
33BMPR21.52007438
34RPS6KB21.50626194
35SGK4941.47459894
36SGK2231.47459894
37PAK61.45462212
38PRKCI1.43172772
39STK381.41020766
40SGK31.35443787
41PRKCG1.30496296
42SIK11.29936936
43TRIB31.28365036
44MARK11.26219253
45CDK51.24447863
46TNIK1.23227025
47STK391.22293103
48MAP3K131.20695158
49LMTK21.20477677
50MAP4K21.19739113
51KSR11.17993942
52CDK91.17834374
53MAPK131.17239985
54PKN21.17182612
55PRKD21.09175265
56OXSR11.04902533
57INSRR1.04753011
58MAPKAPK51.02939295
59ARAF1.01382047
60NEK61.00923406
61VRK21.00583748
62KSR20.99069815
63RIPK10.96839703
64CAMK2A0.94848965
65GRK50.94528086
66STK110.92474988
67MAP3K20.90785042
68SGK10.90114280
69PAK30.89796030
70CAMK10.88729186
71TAOK20.88393304
72CAMK2B0.86604970
73NTRK10.83835382
74SIK30.82582845
75TAOK30.81813287
76TAF10.80624523
77WNK10.79414510
78RPS6KA20.79333196
79CSNK1G20.78306697
80PRKCH0.76668329
81PTK2B0.76102276
82PRKCE0.75638583
83MAPK70.74093345
84WNK30.72625721
85MAP2K60.72279888
86CSNK1D0.71672822
87DYRK20.69991798
88CAMK2G0.69162796
89CCNB10.69064440
90CSNK1G30.68887924
91PDPK10.68679323
92UHMK10.68111436
93BRSK10.68049558
94PDK10.67756638
95FRK0.67736111
96CDK180.66333777
97CAMK1G0.66138328
98ADRBK10.62295470
99TNK20.62240437
100ERBB20.61433475
101CDK150.61412150
102SIK20.61111929
103CSNK1A1L0.60800493
104AURKA0.57337024
105TYRO30.57315827
106HIPK20.55231766
107MAP2K10.55125820
108MAPK80.54321333
109STK160.52844104
110CHUK0.52070284
111CDK80.51585283
112CAMK2D0.50590050
113CDK140.50365573
114TRIM280.50108798
115DYRK1A0.50014662
116MUSK0.49947637
117RPS6KA50.49614338
118PRKAA10.49154097
119MAPK120.48227712
120CDK11A0.48092918
121FES0.47972237
122MAP3K60.46619206
123CAMK40.45952492
124CDK30.45338671
125PHKG20.45279149
126PHKG10.45279149
127PDK20.45261176
128RPS6KA30.44820768
129BRAF0.44680075
130LATS20.44581046
131CAMK1D0.44118256
132FER0.43319897
133RET0.43302618
134CSNK1G10.41776198
135NME10.41676284
136FGFR20.40010986
137PRKACA0.39981840
138PRKCZ0.39473051
139PDK30.39280421
140PDK40.39280421
141BMX0.37865954
142PRKG10.37132846
143PRKCA0.36766581
144DAPK30.35619960
145CSNK1A10.35407282
146RPS6KB10.32079753

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.11562734
2Synaptic vesicle cycle_Homo sapiens_hsa047212.93454579
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77228284
4Circadian entrainment_Homo sapiens_hsa047132.69668034
5Glutamatergic synapse_Homo sapiens_hsa047242.62204166
6Long-term potentiation_Homo sapiens_hsa047202.60541350
7Morphine addiction_Homo sapiens_hsa050322.56601613
8GABAergic synapse_Homo sapiens_hsa047272.49440069
9Olfactory transduction_Homo sapiens_hsa047402.48767883
10Salivary secretion_Homo sapiens_hsa049702.39820784
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29406299
12Amphetamine addiction_Homo sapiens_hsa050312.27575381
13Taste transduction_Homo sapiens_hsa047422.11718381
14Gastric acid secretion_Homo sapiens_hsa049711.94325027
15Renin secretion_Homo sapiens_hsa049241.92348621
16Long-term depression_Homo sapiens_hsa047301.85635078
17Insulin secretion_Homo sapiens_hsa049111.83745327
18Dopaminergic synapse_Homo sapiens_hsa047281.83001110
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81599086
20Calcium signaling pathway_Homo sapiens_hsa040201.76896893
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76768150
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76179295
23Cholinergic synapse_Homo sapiens_hsa047251.65833426
24Oxytocin signaling pathway_Homo sapiens_hsa049211.52412038
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48682822
26Collecting duct acid secretion_Homo sapiens_hsa049661.45692345
27Serotonergic synapse_Homo sapiens_hsa047261.44501163
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42918282
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.37666932
30cAMP signaling pathway_Homo sapiens_hsa040241.37403771
31Butanoate metabolism_Homo sapiens_hsa006501.34966372
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34599123
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31668625
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31081107
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29306164
36Selenocompound metabolism_Homo sapiens_hsa004501.27837934
37Cocaine addiction_Homo sapiens_hsa050301.25936118
38Linoleic acid metabolism_Homo sapiens_hsa005911.25931837
39GnRH signaling pathway_Homo sapiens_hsa049121.19452864
40Tryptophan metabolism_Homo sapiens_hsa003801.18786074
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18512493
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16964550
43Oxidative phosphorylation_Homo sapiens_hsa001901.14578152
44Gap junction_Homo sapiens_hsa045401.13940739
45Type II diabetes mellitus_Homo sapiens_hsa049301.12233950
46Sulfur relay system_Homo sapiens_hsa041221.11514083
47ABC transporters_Homo sapiens_hsa020101.11335258
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10992119
49Sulfur metabolism_Homo sapiens_hsa009201.08623175
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06483103
51Fatty acid biosynthesis_Homo sapiens_hsa000611.02650087
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98224780
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97765705
54Histidine metabolism_Homo sapiens_hsa003400.97143538
55Vitamin B6 metabolism_Homo sapiens_hsa007500.96131618
56Melanogenesis_Homo sapiens_hsa049160.95491151
57Chemical carcinogenesis_Homo sapiens_hsa052040.93646885
58Thyroid hormone synthesis_Homo sapiens_hsa049180.90661317
59beta-Alanine metabolism_Homo sapiens_hsa004100.89387739
60Pancreatic secretion_Homo sapiens_hsa049720.88389717
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87800667
62Estrogen signaling pathway_Homo sapiens_hsa049150.86084400
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.82279898
64Caffeine metabolism_Homo sapiens_hsa002320.81799289
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81505794
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.80470078
67Glioma_Homo sapiens_hsa052140.78530810
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77291980
69Cardiac muscle contraction_Homo sapiens_hsa042600.77224046
70ErbB signaling pathway_Homo sapiens_hsa040120.76678137
71RNA polymerase_Homo sapiens_hsa030200.75634948
72Bile secretion_Homo sapiens_hsa049760.74986352
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74652369
74Circadian rhythm_Homo sapiens_hsa047100.74384256
75Ether lipid metabolism_Homo sapiens_hsa005650.73824891
76Nitrogen metabolism_Homo sapiens_hsa009100.73531314
77Dilated cardiomyopathy_Homo sapiens_hsa054140.73522735
78Fanconi anemia pathway_Homo sapiens_hsa034600.73093619
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72742505
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72255444
81Mineral absorption_Homo sapiens_hsa049780.70676424
82Hippo signaling pathway_Homo sapiens_hsa043900.70290105
83Axon guidance_Homo sapiens_hsa043600.70212075
84Homologous recombination_Homo sapiens_hsa034400.69940460
85Vibrio cholerae infection_Homo sapiens_hsa051100.69807001
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69741030
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.68624978
88Inositol phosphate metabolism_Homo sapiens_hsa005620.68190626
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67970012
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66657839
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.65853935
92Parkinsons disease_Homo sapiens_hsa050120.62149144
93Glucagon signaling pathway_Homo sapiens_hsa049220.62012075
94African trypanosomiasis_Homo sapiens_hsa051430.61856089
95Alcoholism_Homo sapiens_hsa050340.60107135
96MAPK signaling pathway_Homo sapiens_hsa040100.57260583
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56633379
98Choline metabolism in cancer_Homo sapiens_hsa052310.56594476
99Peroxisome_Homo sapiens_hsa041460.55920431
100Huntingtons disease_Homo sapiens_hsa050160.55569014
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53158522
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53051248
103Basal cell carcinoma_Homo sapiens_hsa052170.52519876
104Rap1 signaling pathway_Homo sapiens_hsa040150.49985446
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48530715
106Basal transcription factors_Homo sapiens_hsa030220.47344725
107Retinol metabolism_Homo sapiens_hsa008300.46837340
108Dorso-ventral axis formation_Homo sapiens_hsa043200.46625362
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46431941
110Glycerolipid metabolism_Homo sapiens_hsa005610.46401184
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45836982
112Ovarian steroidogenesis_Homo sapiens_hsa049130.45214640
113Phototransduction_Homo sapiens_hsa047440.44421144
114PPAR signaling pathway_Homo sapiens_hsa033200.42678815
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42318298
116Ras signaling pathway_Homo sapiens_hsa040140.40769084
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35328586
118Insulin signaling pathway_Homo sapiens_hsa049100.35186264
119Oocyte meiosis_Homo sapiens_hsa041140.34825196
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34757780
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34681026
122Arginine biosynthesis_Homo sapiens_hsa002200.34541295
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.33906955
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33032664
125Alzheimers disease_Homo sapiens_hsa050100.32011791
126Melanoma_Homo sapiens_hsa052180.30596170
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29775439
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29282333
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28776545
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.28731303
131Wnt signaling pathway_Homo sapiens_hsa043100.27972909
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27738482
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.24572716
134Non-small cell lung cancer_Homo sapiens_hsa052230.24107072
135Rheumatoid arthritis_Homo sapiens_hsa053230.22376338
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.22228635
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21186730
138AMPK signaling pathway_Homo sapiens_hsa041520.19742602

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