SYT13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.64236244
2Golgi transport vesicle coating (GO:0048200)7.64236244
3endocrine pancreas development (GO:0031018)5.26189933
4protein maturation by protein folding (GO:0022417)5.04732622
5peptide hormone processing (GO:0016486)4.98796956
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.91154021
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87892799
8insulin secretion (GO:0030073)4.87691837
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.66539638
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.63674781
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.63493237
12dendritic spine morphogenesis (GO:0060997)4.53728337
13detection of calcium ion (GO:0005513)4.53541273
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.45280057
15regulation of type B pancreatic cell apoptotic process (GO:2000674)4.37916247
16type B pancreatic cell development (GO:0003323)4.33550333
17protein localization to synapse (GO:0035418)4.32648508
18vocalization behavior (GO:0071625)4.30150128
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28172517
20neuron cell-cell adhesion (GO:0007158)4.26346740
21positive regulation of insulin secretion (GO:0032024)4.25818608
22glandular epithelial cell differentiation (GO:0002067)4.23641789
23postsynaptic membrane organization (GO:0001941)4.21647507
24COPII vesicle coating (GO:0048208)4.19698796
25cellular potassium ion homeostasis (GO:0030007)4.13731277
26synaptic vesicle maturation (GO:0016188)4.09375675
27regulation of insulin secretion (GO:0050796)4.08159548
28regulation of synaptic vesicle exocytosis (GO:2000300)4.04885686
29protein retention in ER lumen (GO:0006621)4.04619066
30glandular epithelial cell development (GO:0002068)3.92192400
31cerebellar Purkinje cell layer development (GO:0021680)3.91814514
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.88497424
33glutamate receptor signaling pathway (GO:0007215)3.83010162
34vesicle coating (GO:0006901)3.79355201
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79124893
36presynaptic membrane assembly (GO:0097105)3.79057711
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78336174
38neurotransmitter-gated ion channel clustering (GO:0072578)3.75441900
39synaptic vesicle exocytosis (GO:0016079)3.71722665
40regulation of peptide hormone secretion (GO:0090276)3.71573965
41pyrimidine nucleobase catabolic process (GO:0006208)3.69653940
42synaptic transmission, glutamatergic (GO:0035249)3.69428944
43peptide hormone secretion (GO:0030072)3.69084194
44neurotransmitter transport (GO:0006836)3.67831366
45regulation of peptide secretion (GO:0002791)3.67324690
46neuron recognition (GO:0008038)3.66649545
47exocrine pancreas development (GO:0031017)3.65977232
48positive regulation of nuclease activity (GO:0032075)3.64839140
49auditory behavior (GO:0031223)3.62421708
50exploration behavior (GO:0035640)3.61736581
51axonal fasciculation (GO:0007413)3.59266007
52peptide secretion (GO:0002790)3.58885837
53chemosensory behavior (GO:0007635)3.58666746
54neuron-neuron synaptic transmission (GO:0007270)3.57674851
55nitric oxide mediated signal transduction (GO:0007263)3.57542484
56positive regulation of synapse maturation (GO:0090129)3.57029564
57regulation of synaptic vesicle transport (GO:1902803)3.53793642
58presynaptic membrane organization (GO:0097090)3.52493873
59positive regulation of peptide hormone secretion (GO:0090277)3.50049913
60regulation of glutamate receptor signaling pathway (GO:1900449)3.49423533
61nucleobase catabolic process (GO:0046113)3.49260054
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.48046487
63ER overload response (GO:0006983)3.47827988
64adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.46723272
65positive regulation of peptide secretion (GO:0002793)3.46140987
66membrane depolarization during action potential (GO:0086010)3.44874509
67transmission of nerve impulse (GO:0019226)3.43526808
68startle response (GO:0001964)3.42671267
69regulation of neurotransmitter levels (GO:0001505)3.42523613
70regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41328757
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41017026
72positive regulation of membrane potential (GO:0045838)3.40860577
73locomotory exploration behavior (GO:0035641)3.39612227
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37149875
75intra-Golgi vesicle-mediated transport (GO:0006891)3.35612585
76negative regulation of catecholamine secretion (GO:0033604)3.34218253
77cellular response to glucagon stimulus (GO:0071377)3.33489536
78sodium ion export (GO:0071436)3.32449198
79regulation of synapse structural plasticity (GO:0051823)3.29287384
80regulation of nuclease activity (GO:0032069)3.28397901
81positive regulation of neurotransmitter transport (GO:0051590)3.27476625
82activation of protein kinase A activity (GO:0034199)3.24782992
83proline transport (GO:0015824)3.24401778
84gamma-aminobutyric acid transport (GO:0015812)3.23997679
85cerebellar granule cell differentiation (GO:0021707)3.23340849
86regulation of glucocorticoid secretion (GO:2000849)3.22985779
87regulation of hormone secretion (GO:0046883)3.22349759
88protein targeting to Golgi (GO:0000042)3.22104795
89regulation of postsynaptic membrane potential (GO:0060078)3.21771767
90layer formation in cerebral cortex (GO:0021819)3.21056032
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.20480237
92glutamate secretion (GO:0014047)3.18312189
93regulation of neurotransmitter secretion (GO:0046928)3.16663103
94negative regulation of norepinephrine secretion (GO:0010700)3.16383555
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16324568
96neuronal ion channel clustering (GO:0045161)3.16125553
97sequestering of metal ion (GO:0051238)3.15944436
98inner ear receptor cell development (GO:0060119)3.15425434
99potassium ion homeostasis (GO:0055075)3.13301689
100regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12885239
101synapse assembly (GO:0007416)3.12700669
102toxin metabolic process (GO:0009404)3.11876855
103endoplasmic reticulum unfolded protein response (GO:0030968)3.11850447
104positive regulation of exocytosis (GO:0045921)3.11824902
105response to dietary excess (GO:0002021)3.10241508
106dendrite morphogenesis (GO:0048813)3.10086361
107serotonin metabolic process (GO:0042428)3.10056891
108positive regulation of neurotransmitter secretion (GO:0001956)3.09035874
109dendritic spine organization (GO:0097061)3.06109750
110L-alpha-amino acid transmembrane transport (GO:1902475)3.05513943
111cellular response to unfolded protein (GO:0034620)3.04936925
112synaptic vesicle docking involved in exocytosis (GO:0016081)3.04354610
113response to auditory stimulus (GO:0010996)3.04220096
114neuronal action potential propagation (GO:0019227)3.01999783
115protein localization to Golgi apparatus (GO:0034067)2.99331530
116positive regulation of vesicle fusion (GO:0031340)2.98250479
117regulation of synapse maturation (GO:0090128)2.97811166
118regulation of peptide transport (GO:0090087)2.97742991
119membrane depolarization (GO:0051899)2.97712231
120regulation of neurotransmitter transport (GO:0051588)2.97061457
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96863378
122cellular response to topologically incorrect protein (GO:0035967)2.96450970
123ER-nucleus signaling pathway (GO:0006984)2.96335952
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95590574
125neurotransmitter secretion (GO:0007269)2.94726057
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94360947
127response to pheromone (GO:0019236)2.92861439
128cell migration in hindbrain (GO:0021535)2.92617746
129synaptic vesicle endocytosis (GO:0048488)2.91639668
130innervation (GO:0060384)2.91129907
131negative regulation of insulin secretion (GO:0046676)2.91018460
132regulation of vesicle fusion (GO:0031338)2.90660714
133establishment of mitochondrion localization (GO:0051654)2.89508170
134columnar/cuboidal epithelial cell development (GO:0002066)2.88141386
135regulation of exocytosis (GO:0017157)2.88084118
136synaptic transmission (GO:0007268)2.87447420
137ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.87257097
138signal release (GO:0023061)2.86677733
139growth hormone secretion (GO:0030252)2.86122925
140regulation of beta-amyloid formation (GO:1902003)2.85898340
141establishment of protein localization to Golgi (GO:0072600)2.85605274
142membrane repolarization during action potential (GO:0086011)2.84871074
143regulation of dendritic spine morphogenesis (GO:0061001)2.83103170
144hormone secretion (GO:0046879)2.82756830
145regulation of synaptic transmission, glutamatergic (GO:0051966)2.81045792
146mechanosensory behavior (GO:0007638)2.80624468
147positive regulation of dendritic spine development (GO:0060999)2.79601643
148potassium ion import (GO:0010107)2.78235082
149peptide transport (GO:0015833)2.77908010
150neurofilament cytoskeleton organization (GO:0060052)2.77023535
151regulation of synaptic plasticity (GO:0048167)2.75890792
152long-term memory (GO:0007616)2.75352086
153response to ischemia (GO:0002931)2.74168513
154cellular response to vitamin D (GO:0071305)2.73595514
155cell communication by electrical coupling (GO:0010644)2.73535432
156retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73501290
157dopamine receptor signaling pathway (GO:0007212)2.73488817
158cellular sodium ion homeostasis (GO:0006883)2.73063100
159macroautophagy (GO:0016236)2.72722385
160behavioral fear response (GO:0001662)2.72427838
161behavioral defense response (GO:0002209)2.72427838
162positive regulation of synaptic transmission, GABAergic (GO:0032230)2.71013023
163synapse organization (GO:0050808)2.71012658
164positive regulation of hormone secretion (GO:0046887)2.70985432
165establishment of synaptic vesicle localization (GO:0097480)2.70358139
166regulation of amyloid precursor protein catabolic process (GO:1902991)2.69926121
167negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69417043
168epithelial cell fate commitment (GO:0072148)2.69357376
169signal peptide processing (GO:0006465)2.67881540
170positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.67204522
171regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.65904432
172hormone transport (GO:0009914)2.65801136
173neuromuscular process controlling posture (GO:0050884)2.63571120
174suckling behavior (GO:0001967)2.62844672
175regulation of neuronal synaptic plasticity (GO:0048168)2.61876581
176neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.60682467
177regulation of norepinephrine secretion (GO:0014061)2.59860161
178regulation of ARF protein signal transduction (GO:0032012)2.59607051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.19558787
2EZH2_22144423_ChIP-Seq_EOC_Human4.64663387
3REST_21632747_ChIP-Seq_MESCs_Mouse2.98949574
4GBX2_23144817_ChIP-Seq_PC3_Human2.80140954
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47361541
6* REST_18959480_ChIP-ChIP_MESCs_Mouse2.39164986
7* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36714957
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25071331
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.24635876
10IGF1R_20145208_ChIP-Seq_DFB_Human2.12543411
11DROSHA_22980978_ChIP-Seq_HELA_Human2.11370845
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11280000
13GATA1_22025678_ChIP-Seq_K562_Human2.10805659
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10527168
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09227616
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05051057
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04611648
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99466661
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.96737391
20TAF15_26573619_Chip-Seq_HEK293_Human1.91642831
21* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90812458
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89976777
23ZNF274_21170338_ChIP-Seq_K562_Hela1.89448757
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88411678
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80193932
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.78018189
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.75514233
28* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75089922
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75044436
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72869489
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72869489
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.71840878
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65233573
34RNF2_27304074_Chip-Seq_NSC_Mouse1.60297292
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.60134072
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59648445
37SMAD4_21799915_ChIP-Seq_A2780_Human1.54133655
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49263849
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47722369
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47019734
41STAT3_23295773_ChIP-Seq_U87_Human1.45082376
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41585558
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39454032
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38905932
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38318860
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.37843161
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37115009
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35891513
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33287189
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31700100
51* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30631201
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27724033
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27085686
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25812902
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25706157
56AR_19668381_ChIP-Seq_PC3_Human1.25419397
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22262224
58YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20123205
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19484969
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17847143
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16809123
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14284589
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13280534
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12982602
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12290476
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11291568
67* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10862721
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10451685
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10390457
70* TCF4_23295773_ChIP-Seq_U87_Human1.09959842
71REST_19997604_ChIP-ChIP_NEURONS_Mouse1.09729329
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09171144
73VDR_22108803_ChIP-Seq_LS180_Human1.08116253
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07438634
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07387548
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06769253
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.06660731
78SMAD3_21741376_ChIP-Seq_ESCs_Human1.06569964
79AR_21572438_ChIP-Seq_LNCaP_Human1.06059916
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05956162
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05918014
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04761002
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04761002
84* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04187408
85AR_25329375_ChIP-Seq_VCAP_Human1.02640941
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02604058
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02330990
88P300_19829295_ChIP-Seq_ESCs_Human1.02275569
89* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01460377
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98757471
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98257382
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98076892
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97288093
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96093909
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96020667
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95442606
97BCAT_22108803_ChIP-Seq_LS180_Human0.94132719
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.94101849
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93947302
100KDM2B_26808549_Chip-Seq_K562_Human0.93348463
101FUS_26573619_Chip-Seq_HEK293_Human0.92428836
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91793704
103JUN_21703547_ChIP-Seq_K562_Human0.91410600
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90535351
105CBP_20019798_ChIP-Seq_JUKART_Human0.90378525
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90378525
107* SMAD3_21741376_ChIP-Seq_EPCs_Human0.89836809
108* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89717716
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.89532107
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88491429
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.88251347
112ERG_21242973_ChIP-ChIP_JURKAT_Human0.88237046
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.88170869
114* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87851027
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87680103
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87615269
117RING1B_27294783_Chip-Seq_ESCs_Mouse0.87538749
118* TET1_21490601_ChIP-Seq_MESCs_Mouse0.87529930
119KDM2B_26808549_Chip-Seq_REH_Human0.86880973
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86205111
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84758746
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83772481
123TP53_22573176_ChIP-Seq_HFKS_Human0.82758264
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82752993
125* NANOG_18555785_Chip-Seq_ESCs_Mouse0.81410358
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80711101
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80132748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.33544494
2MP0002909_abnormal_adrenal_gland4.27144024
3MP0009780_abnormal_chondrocyte_physiolo3.90098848
4MP0002877_abnormal_melanocyte_morpholog3.85219554
5MP0000013_abnormal_adipose_tissue3.52348980
6MP0002693_abnormal_pancreas_physiology3.38891202
7MP0004043_abnormal_pH_regulation3.34252827
8MP0004859_abnormal_synaptic_plasticity3.11998565
9MP0001944_abnormal_pancreas_morphology3.07193395
10MP0010386_abnormal_urinary_bladder2.80210249
11MP0004270_analgesia2.79635639
12MP0005379_endocrine/exocrine_gland_phen2.78859781
13MP0003183_abnormal_peptide_metabolism2.69845984
14MP0003195_calcinosis2.64841266
15MP0000678_abnormal_parathyroid_gland2.53812577
16MP0003635_abnormal_synaptic_transmissio2.35676662
17MP0003122_maternal_imprinting2.33449188
18MP0005645_abnormal_hypothalamus_physiol2.20473639
19MP0005646_abnormal_pituitary_gland2.18306268
20MP0002837_dystrophic_cardiac_calcinosis2.09244037
21MP0006072_abnormal_retinal_apoptosis1.97682476
22MP0002078_abnormal_glucose_homeostasis1.91981656
23MP0003880_abnormal_central_pattern1.88280747
24MP0000778_abnormal_nervous_system1.85439050
25MP0005220_abnormal_exocrine_pancreas1.84354635
26MP0002734_abnormal_mechanical_nocicepti1.77560307
27MP0002063_abnormal_learning/memory/cond1.74296655
28MP0000003_abnormal_adipose_tissue1.70251361
29MP0008961_abnormal_basal_metabolism1.65352275
30MP0002234_abnormal_pharynx_morphology1.65246195
31MP0002572_abnormal_emotion/affect_behav1.64788405
32MP0002064_seizures1.62308951
33MP0009745_abnormal_behavioral_response1.60573686
34MP0002638_abnormal_pupillary_reflex1.59644192
35MP0002736_abnormal_nociception_after1.58237000
36MP0001986_abnormal_taste_sensitivity1.56867307
37MP0008877_abnormal_DNA_methylation1.55375210
38MP0002272_abnormal_nervous_system1.53948201
39MP0003172_abnormal_lysosome_physiology1.50525496
40MP0000569_abnormal_digit_pigmentation1.49715675
41MP0003787_abnormal_imprinting1.49548635
42MP0002733_abnormal_thermal_nociception1.48575907
43MP0001905_abnormal_dopamine_level1.48271036
44MP0004885_abnormal_endolymph1.43302411
45MP0001501_abnormal_sleep_pattern1.38484563
46MP0001765_abnormal_ion_homeostasis1.36216572
47MP0001502_abnormal_circadian_rhythm1.35401397
48MP0003879_abnormal_hair_cell1.34795986
49MP0001529_abnormal_vocalization1.33676251
50MP0000631_abnormal_neuroendocrine_gland1.30020407
51MP0009046_muscle_twitch1.28587676
52MP0001970_abnormal_pain_threshold1.27927101
53MP0001188_hyperpigmentation1.27498519
54MP0003953_abnormal_hormone_level1.25839649
55MP0005535_abnormal_body_temperature1.24373769
56MP0002896_abnormal_bone_mineralization1.21804082
57MP0004145_abnormal_muscle_electrophysio1.21290121
58MP0000955_abnormal_spinal_cord1.17109708
59MP0004264_abnormal_extraembryonic_tissu1.15925954
60MP0002557_abnormal_social/conspecific_i1.15677951
61MP0000462_abnormal_digestive_system1.14109231
62MP0003631_nervous_system_phenotype1.13705846
63MP0002876_abnormal_thyroid_physiology1.11395647
64MP0002928_abnormal_bile_duct1.11043424
65MP0001486_abnormal_startle_reflex1.09848911
66MP0008569_lethality_at_weaning1.06064458
67MP0002067_abnormal_sensory_capabilities1.04779117
68MP0006276_abnormal_autonomic_nervous1.04598680
69MP0002184_abnormal_innervation1.04594999
70MP0004811_abnormal_neuron_physiology1.04322432
71MP0004742_abnormal_vestibular_system1.04212427
72MP0003868_abnormal_feces_composition1.02135720
73MP0002152_abnormal_brain_morphology1.01506224
74MP0005423_abnormal_somatic_nervous1.01499989
75MP0001968_abnormal_touch/_nociception0.99677832
76MP0003329_amyloid_beta_deposits0.98047199
77MP0002735_abnormal_chemical_nociception0.96001456
78MP0001984_abnormal_olfaction0.95175531
79MP0001299_abnormal_eye_distance/0.94803252
80MP0003690_abnormal_glial_cell0.94258312
81MP0003959_abnormal_lean_body0.93362657
82MP0002069_abnormal_eating/drinking_beha0.91260782
83MP0003633_abnormal_nervous_system0.89087993
84MP0003300_gastrointestinal_ulcer0.88798928
85MP0004142_abnormal_muscle_tone0.88198059
86MP0005386_behavior/neurological_phenoty0.87740344
87MP0004924_abnormal_behavior0.87740344
88MP0002163_abnormal_gland_morphology0.87228404
89MP0004858_abnormal_nervous_system0.87153474
90MP0003632_abnormal_nervous_system0.86657567
91MP0004510_myositis0.86050184
92MP0001440_abnormal_grooming_behavior0.85660873
93MP0003119_abnormal_digestive_system0.85369658
94MP0005253_abnormal_eye_physiology0.84078125
95MP0002066_abnormal_motor_capabilities/c0.82901678
96MP0005448_abnormal_energy_balance0.81802549
97MP0002882_abnormal_neuron_morphology0.81687076
98MP0002229_neurodegeneration0.80374237
99MP0001963_abnormal_hearing_physiology0.78383636
100MP0003045_fibrosis0.76666792
101MP0001270_distended_abdomen0.76665084
102MP0005310_abnormal_salivary_gland0.76421564
103MP0008872_abnormal_physiological_respon0.76298490
104MP0000639_abnormal_adrenal_gland0.76003883
105MP0005187_abnormal_penis_morphology0.75264735
106MP0000613_abnormal_salivary_gland0.75087360
107MP0002752_abnormal_somatic_nervous0.74374332
108MP0000230_abnormal_systemic_arterial0.73460217
109MP0000920_abnormal_myelination0.72615869
110MP0004085_abnormal_heartbeat0.71575700
111MP0003123_paternal_imprinting0.70786167
112MP0005058_abnormal_lysosome_morphology0.68498425
113MP0001664_abnormal_digestion0.68107674
114MP0001177_atelectasis0.67666632
115MP0003121_genomic_imprinting0.67396661
116MP0002102_abnormal_ear_morphology0.66884973
117MP0002822_catalepsy0.66541548
118MP0005551_abnormal_eye_electrophysiolog0.66270096
119MP0002090_abnormal_vision0.65341065
120MP0005375_adipose_tissue_phenotype0.64977968
121MP0003634_abnormal_glial_cell0.64603962
122MP0002082_postnatal_lethality0.63656026
123MP0010770_preweaning_lethality0.63656026
124MP0004133_heterotaxia0.63399731
125MP0001485_abnormal_pinna_reflex0.61319104
126MP0010769_abnormal_survival0.60265572
127MP0010768_mortality/aging0.57065378
128MP0000026_abnormal_inner_ear0.55935926

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.11176777
2Hyperinsulinemic hypoglycemia (HP:0000825)7.04273261
3Hypoglycemic seizures (HP:0002173)6.12008619
4Symptomatic seizures (HP:0011145)5.65284407
5Limb dystonia (HP:0002451)5.24561973
6Hypoglycemic coma (HP:0001325)4.69687910
7Abnormality of calcium-phosphate metabolism (HP:0100530)4.60882391
8Insulin-resistant diabetes mellitus (HP:0000831)4.57900952
9Hyperglycemia (HP:0003074)4.34072761
10Visual hallucinations (HP:0002367)4.21867225
11Abnormality of endocrine pancreas physiology (HP:0012093)4.21818136
12Abnormality of the pancreatic islet cells (HP:0006476)4.21818136
13Pancreatic islet-cell hyperplasia (HP:0004510)4.18160069
14Action tremor (HP:0002345)4.11041971
15Large for gestational age (HP:0001520)4.07633354
16Decreased circulating renin level (HP:0003351)3.83304935
17Ketoacidosis (HP:0001993)3.79573976
18Agitation (HP:0000713)3.75412801
19Late onset (HP:0003584)3.51894302
20Papilledema (HP:0001085)3.42105412
21Abnormal pancreas size (HP:0012094)3.36773609
22Ankle clonus (HP:0011448)3.34439885
23EEG with generalized epileptiform discharges (HP:0011198)3.20118079
24Abnormal eating behavior (HP:0100738)3.14533572
25Epileptiform EEG discharges (HP:0011182)3.14363838
26Drooling (HP:0002307)3.12578745
27Mutism (HP:0002300)3.12378512
28Akinesia (HP:0002304)3.11742220
29Polyphagia (HP:0002591)3.11562444
30Hypsarrhythmia (HP:0002521)3.10397006
31Focal motor seizures (HP:0011153)3.09120128
32Urinary glycosaminoglycan excretion (HP:0003541)3.06999164
33Mucopolysacchariduria (HP:0008155)3.06999164
34Hyperparathyroidism (HP:0000843)3.03741496
35Hyperventilation (HP:0002883)2.99101250
36Broad-based gait (HP:0002136)2.98566256
37Hypokalemia (HP:0002900)2.95179806
38Torticollis (HP:0000473)2.92071895
39Diplopia (HP:0000651)2.90119579
40Abnormality of binocular vision (HP:0011514)2.90119579
41Dysostosis multiplex (HP:0000943)2.89887878
42Excessive salivation (HP:0003781)2.89701154
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88010962
44Abnormality of polysaccharide metabolism (HP:0011012)2.88010962
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88010962
46Spastic gait (HP:0002064)2.74931660
47Pheochromocytoma (HP:0002666)2.73498907
48Atonic seizures (HP:0010819)2.72119085
49Retinal atrophy (HP:0001105)2.72046310
50Urinary bladder sphincter dysfunction (HP:0002839)2.64218179
51Abnormality of renin-angiotensin system (HP:0000847)2.64089401
52Unilateral renal agenesis (HP:0000122)2.63466000
53Menstrual irregularities (HP:0000858)2.62405264
54Hypercortisolism (HP:0001578)2.54086917
55Abnormality of the corticospinal tract (HP:0002492)2.52001646
56Intention tremor (HP:0002080)2.51160452
57Osteomalacia (HP:0002749)2.51110383
58Status epilepticus (HP:0002133)2.49651985
59Absence seizures (HP:0002121)2.46516389
60Focal dystonia (HP:0004373)2.44432735
61Insulin resistance (HP:0000855)2.44290990
62Depression (HP:0000716)2.43952306
63Sleep apnea (HP:0010535)2.43099153
64Prominent metopic ridge (HP:0005487)2.42980630
65Increased circulating renin level (HP:0000848)2.42849495
66Abnormality of potassium homeostasis (HP:0011042)2.40983530
67Epileptic encephalopathy (HP:0200134)2.39193397
68Neuroendocrine neoplasm (HP:0100634)2.34359023
69Impaired vibration sensation in the lower limbs (HP:0002166)2.32021212
70Urinary urgency (HP:0000012)2.31329961
71Postural instability (HP:0002172)2.31070078
72Dysdiadochokinesis (HP:0002075)2.29603526
73Focal seizures (HP:0007359)2.29448540
74Poor eye contact (HP:0000817)2.27112224
75Dysmetria (HP:0001310)2.24181931
76Absent speech (HP:0001344)2.23675193
77Anxiety (HP:0000739)2.22659834
78Amblyopia (HP:0000646)2.22125681
79Restlessness (HP:0000711)2.21161702
80Hyperkalemia (HP:0002153)2.20601182
81Craniofacial dystonia (HP:0012179)2.20468167
82Fetal akinesia sequence (HP:0001989)2.16328972
83Dialeptic seizures (HP:0011146)2.16143527
84Conjugated hyperbilirubinemia (HP:0002908)2.15919054
85Diminished movement (HP:0002374)2.14376524
86Morphological abnormality of the pyramidal tract (HP:0002062)2.13457214
87Failure to thrive in infancy (HP:0001531)2.12858862
88Hyperphosphatemia (HP:0002905)2.12566764
89Congenital glaucoma (HP:0001087)2.12513796
90Genetic anticipation (HP:0003743)2.12190842
91Generalized tonic-clonic seizures (HP:0002069)2.12085428
92Cortical visual impairment (HP:0100704)2.10434387
93Supranuclear gaze palsy (HP:0000605)2.10398236
94Dysautonomia (HP:0002459)2.10126325
95Abnormality of the metopic suture (HP:0005556)2.09756222
96Hyperactive renin-angiotensin system (HP:0000841)2.06836206
97Impaired smooth pursuit (HP:0007772)2.05240741
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04938725
99Degeneration of the lateral corticospinal tracts (HP:0002314)2.04938725
100Gait imbalance (HP:0002141)2.03314690
101Neoplasm of the heart (HP:0100544)2.02789353
102Poor suck (HP:0002033)2.02588369
103Macroorchidism (HP:0000053)2.01761290
104Bradykinesia (HP:0002067)1.99080151
105Gaze-evoked nystagmus (HP:0000640)1.98141636
106Truncal ataxia (HP:0002078)1.97832981
107Spastic tetraplegia (HP:0002510)1.95960016
108Adrenal overactivity (HP:0002717)1.95341446
109Hypomagnesemia (HP:0002917)1.94832323
110Generalized myoclonic seizures (HP:0002123)1.94597092
111Abnormal social behavior (HP:0012433)1.91037325
112Impaired social interactions (HP:0000735)1.91037325
113Hypothermia (HP:0002045)1.89063346
114Hypotension (HP:0002615)1.88766523
115Generalized aminoaciduria (HP:0002909)1.88740659
116Postural tremor (HP:0002174)1.87614932
117Impaired vibratory sensation (HP:0002495)1.87315131
118Inability to walk (HP:0002540)1.85124843
119Amyotrophic lateral sclerosis (HP:0007354)1.84676797
120Lower limb muscle weakness (HP:0007340)1.84392572
121Progressive cerebellar ataxia (HP:0002073)1.82315980
122Hemiparesis (HP:0001269)1.81494841
123Ketosis (HP:0001946)1.80110870
124Type II lissencephaly (HP:0007260)1.78161151
125Clonus (HP:0002169)1.77421329
126Abnormality of the fovea (HP:0000493)1.76769830
127Exocrine pancreatic insufficiency (HP:0001738)1.76524962
128Muscular hypotonia of the trunk (HP:0008936)1.76332673
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.75737945
130Hypoplasia of the fovea (HP:0007750)1.75737945
131Hemiplegia (HP:0002301)1.75395299
132Chronic bronchitis (HP:0004469)1.74858739
133Inappropriate behavior (HP:0000719)1.73507925
134Limb hypertonia (HP:0002509)1.73082359
135Global brain atrophy (HP:0002283)1.73021256
136Hypophosphatemia (HP:0002148)1.72485204
137Hyperthyroidism (HP:0000836)1.72444107
138Growth hormone excess (HP:0000845)1.72151821
139Progressive neurologic deterioration (HP:0002344)1.71204796
140Abnormality of the intrinsic pathway (HP:0010989)1.68341710
141Megalencephaly (HP:0001355)1.67475081
142Gout (HP:0001997)1.67082655
143Cerebral inclusion bodies (HP:0100314)1.65645791
144Neurofibrillary tangles (HP:0002185)1.65111248
145Testicular neoplasm (HP:0010788)1.64810922
146Abdominal distention (HP:0003270)1.64161088
147Febrile seizures (HP:0002373)1.64149015
148Resting tremor (HP:0002322)1.64138860
149Generalized hyperpigmentation (HP:0007440)1.64117299
150Hyperphosphaturia (HP:0003109)1.64047326
151Hypocalcemia (HP:0002901)1.63684410
152Myokymia (HP:0002411)1.62986285
153Ventricular fibrillation (HP:0001663)1.61751227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.91294563
2PASK4.17965608
3MAPK153.83699221
4NTRK33.83492710
5PRKD33.40249247
6TAOK33.01080299
7MAP3K22.86757488
8HIPK22.66286188
9WNK32.52558543
10UHMK12.26842190
11NTRK12.24630166
12CAMKK22.17470811
13PHKG11.99695871
14PHKG21.99695871
15FRK1.98739596
16MAP3K11.90842010
17SIK21.87959761
18MAP3K91.84883375
19WNK41.80030602
20SCYL21.75055403
21MAP3K41.69241464
22PINK11.58558348
23CDC42BPA1.47078551
24PRKCH1.41074937
25CAMKK11.38503791
26EPHA41.38030819
27DYRK21.36254840
28PDGFRA1.35143231
29DAPK21.25998256
30PAK61.24767152
31KSR21.22619000
32MINK11.19909507
33MAP2K71.18054290
34PAK31.16476075
35LATS21.14616706
36BCR1.07489844
37MARK11.06097188
38CDK51.05217557
39PRKD21.03190937
40OXSR11.02281529
41PTK21.01211173
42GRK50.95989929
43TYRO30.95762477
44FER0.92496883
45FLT30.92334952
46RET0.91345801
47CDK190.88992983
48PNCK0.88171936
49EPHA30.88161547
50WNK10.87904312
51NTRK20.85919371
52AKT30.85576832
53ERN10.79018480
54PRKCG0.78117500
55MAP2K40.77200054
56FGFR20.76238844
57CAMK2D0.75787281
58CDK140.73549188
59CDK180.73335287
60CAMK2B0.72701012
61CDK150.72599044
62BRSK10.70711597
63IRAK10.70631585
64PRKCE0.70184120
65DAPK10.69695260
66MARK20.67374326
67DYRK1B0.67346134
68LMTK20.66680934
69BRSK20.66110035
70TNIK0.65242866
71PKN10.64937328
72MAP2K60.64886033
73PTK60.64509068
74PRKCZ0.63907151
75DYRK1A0.62886035
76BRAF0.62571819
77CDK11A0.62336860
78CSNK1G30.62305731
79ALK0.61903814
80CAMK2A0.60515999
81SGK4940.60214994
82SGK2230.60214994
83ERBB30.59892689
84IRAK20.59662536
85TAOK10.59053227
86RIPK10.57331949
87TRIB30.57199354
88CSNK1G10.56256908
89PIK3CG0.54251913
90IRAK30.53354929
91CASK0.53271250
92ARAF0.51560504
93BRD40.51379533
94FES0.50382392
95MAPK130.49619651
96STK380.49222935
97CAMK40.48839176
98CAMK2G0.48729158
99TESK10.47649635
100PRKAA10.46483342
101KSR10.46109866
102SGK20.45736863
103ADRBK20.45398127
104STK390.45308836
105CAMK10.44753530
106MAP3K120.44463750
107EIF2AK30.44344005
108PRPF4B0.44136763
109CAMK1G0.43993160
110STK110.43311868
111SGK10.42817667
112RPS6KA30.42261126
113RPS6KA20.42111216
114JAK20.41771534
115CSNK1E0.41088854
116BMPR20.41005215
117PRKG10.39621509
118CSNK1A10.39439627
119MAPK120.39183581
120MAPK100.38748824
121PRKACG0.38283249
122RIPK40.37985130
123SGK30.37690355
124PRKACA0.36912936
125NEK60.36560195
126PRKD10.36247411
127CSNK1A1L0.35148002
128PDPK10.34309781
129FYN0.33646345
130PRKCI0.32955258
131PRKCA0.32583358
132LIMK10.32233626
133PLK20.32139633
134CSNK1G20.32120974
135NME10.31999952
136TRIM280.31151714
137PRKCB0.28683522

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.61636470
2Insulin secretion_Homo sapiens_hsa049113.59908470
3Protein export_Homo sapiens_hsa030603.12682016
4Type II diabetes mellitus_Homo sapiens_hsa049302.52524293
5Synaptic vesicle cycle_Homo sapiens_hsa047212.33283435
6Amphetamine addiction_Homo sapiens_hsa050312.18950381
7Type I diabetes mellitus_Homo sapiens_hsa049402.18447927
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.16195726
9Cocaine addiction_Homo sapiens_hsa050302.01345987
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98739208
11GABAergic synapse_Homo sapiens_hsa047271.97201673
12Vibrio cholerae infection_Homo sapiens_hsa051101.95192683
13Long-term potentiation_Homo sapiens_hsa047201.94528332
14Circadian entrainment_Homo sapiens_hsa047131.85758938
15Sulfur metabolism_Homo sapiens_hsa009201.83882801
16Taste transduction_Homo sapiens_hsa047421.81437819
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77589803
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.72140349
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71265286
20Dopaminergic synapse_Homo sapiens_hsa047281.70208653
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68371595
22Nicotine addiction_Homo sapiens_hsa050331.67861380
23Morphine addiction_Homo sapiens_hsa050321.60122946
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60050516
25Cholinergic synapse_Homo sapiens_hsa047251.50094626
26Glutamatergic synapse_Homo sapiens_hsa047241.49369888
27Pancreatic secretion_Homo sapiens_hsa049721.38182747
28Serotonergic synapse_Homo sapiens_hsa047261.37276012
29Collecting duct acid secretion_Homo sapiens_hsa049661.36478539
30Olfactory transduction_Homo sapiens_hsa047401.25968596
31Renin secretion_Homo sapiens_hsa049241.21905274
32Phototransduction_Homo sapiens_hsa047441.18522767
33Circadian rhythm_Homo sapiens_hsa047101.15563071
34Glucagon signaling pathway_Homo sapiens_hsa049221.14983218
35Estrogen signaling pathway_Homo sapiens_hsa049151.14822530
36Thyroid hormone synthesis_Homo sapiens_hsa049181.13002912
37N-Glycan biosynthesis_Homo sapiens_hsa005101.11199827
38Gastric acid secretion_Homo sapiens_hsa049711.10574567
39Salivary secretion_Homo sapiens_hsa049701.10242423
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10222403
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09310181
42Axon guidance_Homo sapiens_hsa043601.04055349
43Long-term depression_Homo sapiens_hsa047301.03016753
44Lysosome_Homo sapiens_hsa041420.97856117
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94100823
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92890053
47Vitamin B6 metabolism_Homo sapiens_hsa007500.90788102
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89584098
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.88262647
50GnRH signaling pathway_Homo sapiens_hsa049120.87356849
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86408944
52cAMP signaling pathway_Homo sapiens_hsa040240.85855855
53Oxytocin signaling pathway_Homo sapiens_hsa049210.85173052
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.84921576
55Gap junction_Homo sapiens_hsa045400.84154857
56Bile secretion_Homo sapiens_hsa049760.81021267
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79943433
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78921312
59Calcium signaling pathway_Homo sapiens_hsa040200.78699106
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76937562
61Prion diseases_Homo sapiens_hsa050200.76738213
62Dorso-ventral axis formation_Homo sapiens_hsa043200.72083039
63Prolactin signaling pathway_Homo sapiens_hsa049170.72029134
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69755837
65Melanogenesis_Homo sapiens_hsa049160.69733969
66Regulation of autophagy_Homo sapiens_hsa041400.67963472
67Insulin resistance_Homo sapiens_hsa049310.65217986
68Alcoholism_Homo sapiens_hsa050340.63499707
69Glioma_Homo sapiens_hsa052140.61884517
70mTOR signaling pathway_Homo sapiens_hsa041500.61755556
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61123625
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60090703
73Insulin signaling pathway_Homo sapiens_hsa049100.59267255
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58959166
75Oxidative phosphorylation_Homo sapiens_hsa001900.57977067
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55327437
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52809165
78Selenocompound metabolism_Homo sapiens_hsa004500.52708114
79Inositol phosphate metabolism_Homo sapiens_hsa005620.52264691
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51761998
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50487129
82Mineral absorption_Homo sapiens_hsa049780.49291261
83Ether lipid metabolism_Homo sapiens_hsa005650.47312400
84ErbB signaling pathway_Homo sapiens_hsa040120.46708178
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46665357
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46614867
87ABC transporters_Homo sapiens_hsa020100.44980130
88Rap1 signaling pathway_Homo sapiens_hsa040150.44160647
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.43611344
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43086043
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41684290
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40701292
93Other glycan degradation_Homo sapiens_hsa005110.40309438
94Tryptophan metabolism_Homo sapiens_hsa003800.39946373
95Dilated cardiomyopathy_Homo sapiens_hsa054140.38445117
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38021463
97Butanoate metabolism_Homo sapiens_hsa006500.36039475
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35401715
99Galactose metabolism_Homo sapiens_hsa000520.35095713
100MAPK signaling pathway_Homo sapiens_hsa040100.34892410
101beta-Alanine metabolism_Homo sapiens_hsa004100.34620921
102Cardiac muscle contraction_Homo sapiens_hsa042600.33190410
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.32582859
104Parkinsons disease_Homo sapiens_hsa050120.32533451
105Ovarian steroidogenesis_Homo sapiens_hsa049130.32403731
106Sphingolipid metabolism_Homo sapiens_hsa006000.32300667
107Endometrial cancer_Homo sapiens_hsa052130.30353779
108Oocyte meiosis_Homo sapiens_hsa041140.29577251
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29222866
110Endocytosis_Homo sapiens_hsa041440.28649801
111Renal cell carcinoma_Homo sapiens_hsa052110.28499540
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27643474
113Histidine metabolism_Homo sapiens_hsa003400.26897982
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26418294
115Ras signaling pathway_Homo sapiens_hsa040140.26343370
116Tight junction_Homo sapiens_hsa045300.26113485
117Protein digestion and absorption_Homo sapiens_hsa049740.25780303
118AMPK signaling pathway_Homo sapiens_hsa041520.25635274
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25600513
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.25337133
121Choline metabolism in cancer_Homo sapiens_hsa052310.24370776
122Alzheimers disease_Homo sapiens_hsa050100.24089288

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »