SYT14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85387690
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.68198456
3water-soluble vitamin biosynthetic process (GO:0042364)4.52642835
4behavioral response to nicotine (GO:0035095)4.16550722
5regulation of hexokinase activity (GO:1903299)4.14682223
6regulation of glucokinase activity (GO:0033131)4.14682223
7neuron cell-cell adhesion (GO:0007158)4.08699943
8synaptic vesicle exocytosis (GO:0016079)4.01420699
9synaptic vesicle maturation (GO:0016188)3.96110440
10regulation of synaptic vesicle exocytosis (GO:2000300)3.93788587
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79482547
12locomotory exploration behavior (GO:0035641)3.77945134
13COPI coating of Golgi vesicle (GO:0048205)3.77135449
14Golgi transport vesicle coating (GO:0048200)3.77135449
15vocalization behavior (GO:0071625)3.76652312
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75436402
17positive regulation of glycolytic process (GO:0045821)3.66320937
18innervation (GO:0060384)3.57449170
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.53904262
20response to pheromone (GO:0019236)3.52888740
21insulin secretion (GO:0030073)3.46982760
22kidney morphogenesis (GO:0060993)3.45929402
23detection of calcium ion (GO:0005513)3.45764376
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45022199
25regulation of glutamate receptor signaling pathway (GO:1900449)3.41335202
26regulation of synaptic vesicle transport (GO:1902803)3.38271755
27chemosensory behavior (GO:0007635)3.35367501
28inner ear receptor cell development (GO:0060119)3.34779173
29protein localization to synapse (GO:0035418)3.31479267
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30877979
31glutamate secretion (GO:0014047)3.30006673
32cerebellar Purkinje cell differentiation (GO:0021702)3.25121380
33layer formation in cerebral cortex (GO:0021819)3.23183780
34protein polyglutamylation (GO:0018095)3.22362079
35regulation of type B pancreatic cell apoptotic process (GO:2000674)3.19315672
36neurotransmitter secretion (GO:0007269)3.18833378
37inositol phosphate catabolic process (GO:0071545)3.17321129
38dendritic spine morphogenesis (GO:0060997)3.17134561
39gamma-aminobutyric acid transport (GO:0015812)3.15761927
40axonal fasciculation (GO:0007413)3.15345079
41proline transport (GO:0015824)3.15106195
42neuron recognition (GO:0008038)3.13165939
43positive regulation of protein autophosphorylation (GO:0031954)3.09571030
44positive regulation of synapse maturation (GO:0090129)3.07134323
45negative regulation of protein oligomerization (GO:0032460)3.06525031
46presynaptic membrane assembly (GO:0097105)3.06019376
47respiratory chain complex IV assembly (GO:0008535)3.01965990
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.01736586
49cellular ketone body metabolic process (GO:0046950)3.01353706
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00487955
51pyrimidine nucleobase catabolic process (GO:0006208)2.99017982
52exploration behavior (GO:0035640)2.98970905
53lactate metabolic process (GO:0006089)2.96843678
54protein targeting to Golgi (GO:0000042)2.96643504
55synaptic transmission, glutamatergic (GO:0035249)2.95435684
56reflex (GO:0060004)2.94637556
57ionotropic glutamate receptor signaling pathway (GO:0035235)2.91622128
58neuron-neuron synaptic transmission (GO:0007270)2.90060937
59regulation of neuronal synaptic plasticity (GO:0048168)2.90040091
60negative regulation of hormone biosynthetic process (GO:0032353)2.88602254
61cerebellum development (GO:0021549)2.88116967
62auditory behavior (GO:0031223)2.87148972
63nucleobase catabolic process (GO:0046113)2.86786346
64startle response (GO:0001964)2.86305788
65DNA deamination (GO:0045006)2.86108951
66nitric oxide mediated signal transduction (GO:0007263)2.86010662
67protein maturation by protein folding (GO:0022417)2.85570819
68regulation of calcium ion-dependent exocytosis (GO:0017158)2.85236128
69dentate gyrus development (GO:0021542)2.83322464
70regulation of action potential (GO:0098900)2.83302373
71activation of protein kinase A activity (GO:0034199)2.82758086
72regulation of long-term neuronal synaptic plasticity (GO:0048169)2.80071575
73cerebellar Purkinje cell layer development (GO:0021680)2.79942414
74positive regulation of membrane potential (GO:0045838)2.79512341
75vesicle transport along microtubule (GO:0047496)2.78982701
76peptide hormone processing (GO:0016486)2.77050018
77negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76528368
78regulation of feeding behavior (GO:0060259)2.76429888
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75489639
80dendrite morphogenesis (GO:0048813)2.75390705
81postsynaptic membrane organization (GO:0001941)2.75088941
82prostate gland growth (GO:0060736)2.74274326
83endocrine pancreas development (GO:0031018)2.73392343
84behavioral response to ethanol (GO:0048149)2.73277865
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73098317
86neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.72947923
87positive regulation of synaptic transmission, GABAergic (GO:0032230)2.71792022
88glutamate receptor signaling pathway (GO:0007215)2.70939414
89establishment of protein localization to Golgi (GO:0072600)2.70531867
90synaptic vesicle endocytosis (GO:0048488)2.70334805
91regulation of insulin secretion (GO:0050796)2.70165502
92ketone body metabolic process (GO:1902224)2.69435281
93neuronal action potential (GO:0019228)2.69117874
94cochlea development (GO:0090102)2.68979022
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68824218
96sulfation (GO:0051923)2.68668288
97long-term memory (GO:0007616)2.67960675
98regulation of postsynaptic membrane potential (GO:0060078)2.67503034
99retinal ganglion cell axon guidance (GO:0031290)2.66856667
100regulation of vesicle fusion (GO:0031338)2.66326074
101mechanosensory behavior (GO:0007638)2.66228680
102presynaptic membrane organization (GO:0097090)2.65990641
103transmission of nerve impulse (GO:0019226)2.65616551
104protein localization to cilium (GO:0061512)2.65459946
105organelle transport along microtubule (GO:0072384)2.64624191
106positive regulation of respiratory burst (GO:0060267)2.64610011
107mating behavior (GO:0007617)2.64523673
108adaptation of signaling pathway (GO:0023058)2.64375915
109inositol phosphate dephosphorylation (GO:0046855)2.64310718
110phosphorylated carbohydrate dephosphorylation (GO:0046838)2.64310718
111righting reflex (GO:0060013)2.64280342
112membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63940514
113axoneme assembly (GO:0035082)2.63821741
114neurotransmitter transport (GO:0006836)2.62358202
115positive regulation of exocytosis (GO:0045921)2.61042635
116regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60556873
117neuronal action potential propagation (GO:0019227)2.60422924
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59873136
119membrane hyperpolarization (GO:0060081)2.59738053
120synapse assembly (GO:0007416)2.59499202
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.59489502
122peptide hormone secretion (GO:0030072)2.59104886
123hindbrain development (GO:0030902)2.59004280
124negative regulation of acute inflammatory response (GO:0002674)2.58674115
125ER overload response (GO:0006983)2.57309191
126neurotransmitter-gated ion channel clustering (GO:0072578)2.56869975
127cytochrome complex assembly (GO:0017004)2.56825942
128negative regulation of dendrite development (GO:2000171)2.56304743
129cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54633607
130pituitary gland development (GO:0021983)2.54633439
131cornea development in camera-type eye (GO:0061303)2.53329845
132signal release (GO:0023061)2.53137764
133long-term synaptic potentiation (GO:0060291)2.53047952
134regulation of glucocorticoid secretion (GO:2000849)2.52973295
135membrane depolarization during action potential (GO:0086010)2.52679868
136spinal cord motor neuron differentiation (GO:0021522)2.52574919
137serotonin metabolic process (GO:0042428)2.52064078
138suckling behavior (GO:0001967)2.51415722
139retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50652609
140regulation of neurotransmitter secretion (GO:0046928)2.50424982
141fear response (GO:0042596)2.50222893
142peptide secretion (GO:0002790)2.50070134
143magnesium ion transport (GO:0015693)2.48582391
144regulation of cilium movement (GO:0003352)2.47969158
145gamma-aminobutyric acid signaling pathway (GO:0007214)2.47856316
146L-fucose catabolic process (GO:0042355)2.47436102
147fucose catabolic process (GO:0019317)2.47436102
148L-fucose metabolic process (GO:0042354)2.47436102
149DNA double-strand break processing (GO:0000729)2.47282667
150negative regulation of telomere maintenance (GO:0032205)2.46860930
151negative regulation of catecholamine secretion (GO:0033604)2.46390260
152striatum development (GO:0021756)2.46298850
153regulation of exocytosis (GO:0017157)2.45394573
154positive regulation of peptide hormone secretion (GO:0090277)2.45258378
155cell migration in hindbrain (GO:0021535)2.44577744
156calcium ion-dependent exocytosis (GO:0017156)2.44538263
157synapse organization (GO:0050808)2.44535017
158glycerophospholipid catabolic process (GO:0046475)2.42804727
159regulation of neurotransmitter uptake (GO:0051580)2.42753856
160epithelial cilium movement (GO:0003351)2.42584988
161polyol catabolic process (GO:0046174)2.40624323
162action potential (GO:0001508)2.39723925
163negative regulation of membrane potential (GO:0045837)2.39499904
164preassembly of GPI anchor in ER membrane (GO:0016254)2.38502960
165regulation of energy homeostasis (GO:2000505)2.37564073
166tryptophan catabolic process (GO:0006569)2.37152246
167indole-containing compound catabolic process (GO:0042436)2.37152246
168indolalkylamine catabolic process (GO:0046218)2.37152246
1693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.36279965
170purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.36279965
171positive regulation of peptide secretion (GO:0002793)2.36277474
172indolalkylamine metabolic process (GO:0006586)2.36030484
173prenylation (GO:0097354)2.36016685
174protein prenylation (GO:0018342)2.36016685
175negative regulation of glycogen metabolic process (GO:0070874)2.35734323
176protein complex biogenesis (GO:0070271)2.35576876
177primary amino compound metabolic process (GO:1901160)2.35243037
178positive regulation of potassium ion transmembrane transport (GO:1901381)2.35181450
179protein K11-linked deubiquitination (GO:0035871)2.34369434
180nonmotile primary cilium assembly (GO:0035058)2.34299788
181kynurenine metabolic process (GO:0070189)2.33466493
182positive regulation of meiosis (GO:0045836)2.32006032
183positive regulation of insulin secretion (GO:0032024)2.31745711
184negative regulation of hormone metabolic process (GO:0032351)2.31287834
185positive regulation of oligodendrocyte differentiation (GO:0048714)2.31235212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70372410
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70903000
3* GBX2_23144817_ChIP-Seq_PC3_Human3.56953398
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.79378117
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.72356119
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44214189
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34068375
8VDR_22108803_ChIP-Seq_LS180_Human2.32814373
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25410687
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25365277
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.18225110
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16371698
13IGF1R_20145208_ChIP-Seq_DFB_Human2.14701235
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.11567997
15* REST_18959480_ChIP-ChIP_MESCs_Mouse2.09764306
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08171156
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05293547
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01391649
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.95198498
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88239766
21ZNF274_21170338_ChIP-Seq_K562_Hela1.86694824
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86357654
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85828651
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85168254
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80475521
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79134609
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79134609
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77376995
29SMAD4_21799915_ChIP-Seq_A2780_Human1.77263182
30DROSHA_22980978_ChIP-Seq_HELA_Human1.76468580
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.75751678
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75476454
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73246681
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69968922
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.67386098
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.67143403
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66483703
38* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65493503
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65035393
40FUS_26573619_Chip-Seq_HEK293_Human1.64187128
41ER_23166858_ChIP-Seq_MCF-7_Human1.63934317
42TAF15_26573619_Chip-Seq_HEK293_Human1.60400695
43STAT3_23295773_ChIP-Seq_U87_Human1.60390544
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59128709
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58352780
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57643848
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57390515
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54991125
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54292416
50P300_19829295_ChIP-Seq_ESCs_Human1.51014155
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49540056
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47632758
53CBP_20019798_ChIP-Seq_JUKART_Human1.47632758
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.45976691
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.45796811
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.45070020
57RNF2_27304074_Chip-Seq_NSC_Mouse1.44710630
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43845838
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42685026
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40481531
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.39550029
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39038259
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38557653
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38449910
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36967664
66* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36813898
67* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33611916
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.32217267
69* TCF4_23295773_ChIP-Seq_U87_Human1.31604681
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30644295
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29934069
72* AR_19668381_ChIP-Seq_PC3_Human1.29751796
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28657394
74* EZH2_27294783_Chip-Seq_NPCs_Mouse1.27711981
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27679797
76* NFE2_27457419_Chip-Seq_LIVER_Mouse1.27568465
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26579317
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26278564
79* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23544892
80* P53_22387025_ChIP-Seq_ESCs_Mouse1.23178936
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23044254
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22987152
83TP53_22573176_ChIP-Seq_HFKS_Human1.22906152
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21611175
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20502627
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.18766649
87* TCF4_22108803_ChIP-Seq_LS180_Human1.17593179
88MYC_18940864_ChIP-ChIP_HL60_Human1.17270660
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17109993
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16264388
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.15835828
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15347941
93NANOG_19829295_ChIP-Seq_ESCs_Human1.15219839
94SOX2_19829295_ChIP-Seq_ESCs_Human1.15219839
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13560285
96RUNX2_22187159_ChIP-Seq_PCA_Human1.11953919
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11672184
98* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11480793
99* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10793076
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10313755
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.09604803
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09131669
103* NANOG_18555785_Chip-Seq_ESCs_Mouse1.07920597
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.07704315
105* AR_25329375_ChIP-Seq_VCAP_Human1.07196166
106* E2F1_18555785_Chip-Seq_ESCs_Mouse1.06632617
107* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06436022
108PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05919265
109* SMAD4_21741376_ChIP-Seq_EPCs_Human1.05721046
110* STAT3_18555785_Chip-Seq_ESCs_Mouse1.05461217
111* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05338676
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04886253
113* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04694215
114* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04452677
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04425415
116* CRX_20693478_ChIP-Seq_RETINA_Mouse1.04379971
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04058728
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03430262
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03430262
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03422904
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03013821
122IRF1_19129219_ChIP-ChIP_H3396_Human1.02868213
123* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02668864
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01973486
125* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01675358
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.01553818
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00593689
128* P300_18555785_Chip-Seq_ESCs_Mouse1.00257715
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00085554
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99757145
131RING1B_27294783_Chip-Seq_ESCs_Mouse0.99687721
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99607921
133REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96226267
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96065828
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95749937
136BCAT_22108803_ChIP-Seq_LS180_Human0.95566930
137AR_21572438_ChIP-Seq_LNCaP_Human0.95363615
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95281984
139SOX9_26525672_Chip-Seq_HEART_Mouse0.95172467
140EWS_26573619_Chip-Seq_HEK293_Human0.94850708
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94844131
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.94064774
143SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93362707
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91353436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.75312219
2MP0004270_analgesia3.24901450
3MP0009780_abnormal_chondrocyte_physiolo2.93435721
4MP0003635_abnormal_synaptic_transmissio2.78716715
5MP0003880_abnormal_central_pattern2.71902389
6MP0002102_abnormal_ear_morphology2.67783009
7MP0003122_maternal_imprinting2.67581841
8MP0003195_calcinosis2.66209036
9MP0002909_abnormal_adrenal_gland2.64837744
10MP0003283_abnormal_digestive_organ2.51171829
11MP0002063_abnormal_learning/memory/cond2.33426440
12MP0006072_abnormal_retinal_apoptosis2.23512550
13MP0003787_abnormal_imprinting2.11871642
14MP0002734_abnormal_mechanical_nocicepti2.09593379
15MP0009745_abnormal_behavioral_response2.07173539
16MP0004043_abnormal_pH_regulation2.05213063
17MP0002572_abnormal_emotion/affect_behav2.02854323
18MP0005646_abnormal_pituitary_gland1.94896440
19MP0002064_seizures1.90993806
20MP0010386_abnormal_urinary_bladder1.88026389
21MP0005423_abnormal_somatic_nervous1.86972307
22MP0005645_abnormal_hypothalamus_physiol1.86565319
23MP0001486_abnormal_startle_reflex1.78424506
24MP0003890_abnormal_embryonic-extraembry1.76581702
25MP0002272_abnormal_nervous_system1.74381673
26MP0001968_abnormal_touch/_nociception1.74201379
27MP0009046_muscle_twitch1.73954753
28MP0002638_abnormal_pupillary_reflex1.73814429
29MP0000631_abnormal_neuroendocrine_gland1.73416044
30MP0003121_genomic_imprinting1.71959907
31MP0002184_abnormal_innervation1.69095753
32MP0002693_abnormal_pancreas_physiology1.66187292
33MP0000778_abnormal_nervous_system1.65393295
34MP0005551_abnormal_eye_electrophysiolog1.63818374
35MP0000013_abnormal_adipose_tissue1.63034219
36MP0002733_abnormal_thermal_nociception1.62106056
37MP0001944_abnormal_pancreas_morphology1.61763201
38MP0002557_abnormal_social/conspecific_i1.61006237
39MP0006276_abnormal_autonomic_nervous1.60322844
40MP0003183_abnormal_peptide_metabolism1.56363851
41MP0003123_paternal_imprinting1.55320812
42MP0002160_abnormal_reproductive_system1.54653094
43MP0002877_abnormal_melanocyte_morpholog1.54239471
44MP0001502_abnormal_circadian_rhythm1.53249158
45MP0002163_abnormal_gland_morphology1.53132637
46MP0005187_abnormal_penis_morphology1.52405935
47MP0001984_abnormal_olfaction1.51927814
48MP0003011_delayed_dark_adaptation1.51611534
49MP0002067_abnormal_sensory_capabilities1.49941039
50MP0004811_abnormal_neuron_physiology1.48587648
51MP0002822_catalepsy1.47287810
52MP0002837_dystrophic_cardiac_calcinosis1.45204652
53MP0002735_abnormal_chemical_nociception1.42930117
54MP0004142_abnormal_muscle_tone1.41285010
55MP0005386_behavior/neurological_phenoty1.40188390
56MP0004924_abnormal_behavior1.40188390
57MP0005253_abnormal_eye_physiology1.39091442
58MP0000955_abnormal_spinal_cord1.38884860
59MP0003879_abnormal_hair_cell1.38635220
60MP0001970_abnormal_pain_threshold1.37451181
61MP0001188_hyperpigmentation1.36886531
62MP0001529_abnormal_vocalization1.36750985
63MP0005379_endocrine/exocrine_gland_phen1.36736404
64MP0002234_abnormal_pharynx_morphology1.34303918
65MP0002882_abnormal_neuron_morphology1.32021104
66MP0002938_white_spotting1.31355904
67MP0010234_abnormal_vibrissa_follicle1.31229157
68MP0008872_abnormal_physiological_respon1.30322509
69MP0008961_abnormal_basal_metabolism1.27506464
70MP0000678_abnormal_parathyroid_gland1.27446540
71MP0001440_abnormal_grooming_behavior1.27203737
72MP0001501_abnormal_sleep_pattern1.25691368
73MP0000516_abnormal_urinary_system1.23596505
74MP0005367_renal/urinary_system_phenotyp1.23596505
75MP0002928_abnormal_bile_duct1.20292361
76MP0000427_abnormal_hair_cycle1.20210354
77MP0005389_reproductive_system_phenotype1.16280506
78MP0003119_abnormal_digestive_system1.15839533
79MP0004858_abnormal_nervous_system1.15648062
80MP0005499_abnormal_olfactory_system1.14434663
81MP0005394_taste/olfaction_phenotype1.14434663
82MP0001986_abnormal_taste_sensitivity1.13991252
83MP0006292_abnormal_olfactory_placode1.12995057
84MP0002152_abnormal_brain_morphology1.12794918
85MP0001299_abnormal_eye_distance/1.11064580
86MP0004134_abnormal_chest_morphology1.10396065
87MP0004145_abnormal_muscle_electrophysio1.10149183
88MP0008569_lethality_at_weaning1.10135833
89MP0002653_abnormal_ependyma_morphology1.07394924
90MP0002751_abnormal_autonomic_nervous1.06060144
91MP0002876_abnormal_thyroid_physiology1.05966052
92MP0001905_abnormal_dopamine_level1.05645843
93MP0002736_abnormal_nociception_after1.04583086
94MP0002066_abnormal_motor_capabilities/c1.04508470
95MP0008877_abnormal_DNA_methylation1.03306407
96MP0002229_neurodegeneration1.00389993
97MP0000569_abnormal_digit_pigmentation0.99371711
98MP0005084_abnormal_gallbladder_morpholo0.98560595
99MP0003646_muscle_fatigue0.95586801
100MP0002078_abnormal_glucose_homeostasis0.95291528
101MP0008789_abnormal_olfactory_epithelium0.94150837
102MP0004885_abnormal_endolymph0.92990776
103MP0003937_abnormal_limbs/digits/tail_de0.92575935
104MP0004233_abnormal_muscle_weight0.91746360
105MP0000049_abnormal_middle_ear0.91403185
106MP0003861_abnormal_nervous_system0.88539116
107MP0002069_abnormal_eating/drinking_beha0.88173153
108MP0001485_abnormal_pinna_reflex0.87757217
109MP0002254_reproductive_system_inflammat0.87145600
110MP0004085_abnormal_heartbeat0.85844538
111MP0004133_heterotaxia0.84371702
112MP0002752_abnormal_somatic_nervous0.84229041
113MP0004215_abnormal_myocardial_fiber0.81484664
114MP0005195_abnormal_posterior_eye0.80136317
115MP0000639_abnormal_adrenal_gland0.79572134
116MP0003137_abnormal_impulse_conducting0.79251058
117MP0010678_abnormal_skin_adnexa0.78798161
118MP0000003_abnormal_adipose_tissue0.77428191
119MP0001963_abnormal_hearing_physiology0.76340064
120MP0002090_abnormal_vision0.74503175
121MP0004742_abnormal_vestibular_system0.74369285
122MP0005220_abnormal_exocrine_pancreas0.72904975
123MP0003953_abnormal_hormone_level0.72506026
124MP0003938_abnormal_ear_development0.72156012
125MP0004264_abnormal_extraembryonic_tissu0.70734113
126MP0009703_decreased_birth_body0.70642946
127MP0003633_abnormal_nervous_system0.67077953
128MP0005535_abnormal_body_temperature0.66312473
129MP0002896_abnormal_bone_mineralization0.65938755

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.27534022
2Focal motor seizures (HP:0011153)4.04221477
3Visual hallucinations (HP:0002367)3.69202347
4Hyperinsulinemic hypoglycemia (HP:0000825)3.63891534
5Hypothermia (HP:0002045)3.60613130
6Epileptic encephalopathy (HP:0200134)3.44811628
7Focal seizures (HP:0007359)3.41677486
8Pancreatic cysts (HP:0001737)3.35637559
9Ketoacidosis (HP:0001993)3.33361064
10Pancreatic fibrosis (HP:0100732)3.27636428
11Methylmalonic acidemia (HP:0002912)3.21225239
12Atonic seizures (HP:0010819)3.16753423
13Absence seizures (HP:0002121)3.14217999
14Febrile seizures (HP:0002373)3.13111917
15Epileptiform EEG discharges (HP:0011182)3.10749231
16EEG with generalized epileptiform discharges (HP:0011198)3.09155929
17Hypoglycemic seizures (HP:0002173)3.08413347
18Agitation (HP:0000713)2.98882203
19Hypoglycemic coma (HP:0001325)2.98234781
20Hypsarrhythmia (HP:0002521)2.97513012
21True hermaphroditism (HP:0010459)2.90636967
22Dialeptic seizures (HP:0011146)2.88442101
23Drooling (HP:0002307)2.83574803
24Excessive salivation (HP:0003781)2.83574803
25Nephronophthisis (HP:0000090)2.82322581
26Symptomatic seizures (HP:0011145)2.79761181
27Papilledema (HP:0001085)2.79452579
28Molar tooth sign on MRI (HP:0002419)2.76647578
29Abnormality of midbrain morphology (HP:0002418)2.76647578
30Osteomalacia (HP:0002749)2.70260450
31Progressive cerebellar ataxia (HP:0002073)2.67889897
32Myokymia (HP:0002411)2.67612586
33Abnormality of calcium-phosphate metabolism (HP:0100530)2.65926398
34Neoplasm of the adrenal cortex (HP:0100641)2.57526512
35Generalized tonic-clonic seizures (HP:0002069)2.56082048
36Abolished electroretinogram (ERG) (HP:0000550)2.55368115
37Macroorchidism (HP:0000053)2.52813072
38Methylmalonic aciduria (HP:0012120)2.46391028
39Insomnia (HP:0100785)2.45944038
40Gait imbalance (HP:0002141)2.45351168
41Hyperventilation (HP:0002883)2.43863761
42Pendular nystagmus (HP:0012043)2.43402009
43Abnormality of the renal cortex (HP:0011035)2.41876659
44Depression (HP:0000716)2.41069293
45Ketosis (HP:0001946)2.38998195
46Progressive inability to walk (HP:0002505)2.37995998
47Abnormality of the metopic suture (HP:0005556)2.37042031
48Prominent metopic ridge (HP:0005487)2.36153505
49Furrowed tongue (HP:0000221)2.34909694
50Abnormality of the renal medulla (HP:0100957)2.34379137
51Broad-based gait (HP:0002136)2.29448394
52Papillary thyroid carcinoma (HP:0002895)2.28017854
53Pancreatic islet-cell hyperplasia (HP:0004510)2.27927958
54Congenital stationary night blindness (HP:0007642)2.27363309
55Failure to thrive in infancy (HP:0001531)2.25655741
56Volvulus (HP:0002580)2.25003780
57Progressive macrocephaly (HP:0004481)2.24612229
58Renal cortical cysts (HP:0000803)2.24258815
59Hamartoma of the eye (HP:0010568)2.23570838
60Protruding tongue (HP:0010808)2.23316766
61Action tremor (HP:0002345)2.22430775
62Insulin-resistant diabetes mellitus (HP:0000831)2.21267995
63Central scotoma (HP:0000603)2.19862918
64Congenital primary aphakia (HP:0007707)2.19516227
65Inability to walk (HP:0002540)2.16903431
66Conjunctival hamartoma (HP:0100780)2.16835029
67Abnormality of vitamin B metabolism (HP:0004340)2.16505509
68Bony spicule pigmentary retinopathy (HP:0007737)2.16072459
69Decreased circulating renin level (HP:0003351)2.15745820
70Abnormal rod and cone electroretinograms (HP:0008323)2.13684200
71Thyroiditis (HP:0100646)2.12563350
72Hemiparesis (HP:0001269)2.12359420
73Pheochromocytoma (HP:0002666)2.08328661
74Hypomagnesemia (HP:0002917)2.07576994
75Abnormality of the pancreatic islet cells (HP:0006476)2.07486105
76Abnormality of endocrine pancreas physiology (HP:0012093)2.07486105
77Attenuation of retinal blood vessels (HP:0007843)2.05820450
78Type II diabetes mellitus (HP:0005978)2.05158559
79Anxiety (HP:0000739)2.05126604
80Cystic liver disease (HP:0006706)2.04844403
81Type II lissencephaly (HP:0007260)2.04402099
82Hyperglycemia (HP:0003074)2.04062663
83* Truncal ataxia (HP:0002078)2.02742332
84Amyotrophic lateral sclerosis (HP:0007354)2.00793664
85Muscular hypotonia of the trunk (HP:0008936)1.99202197
86Absent eyebrow (HP:0002223)1.98764189
87Ankle clonus (HP:0011448)1.96443375
88Nephrogenic diabetes insipidus (HP:0009806)1.94954193
89Absent speech (HP:0001344)1.94324447
90Polydipsia (HP:0001959)1.94014060
91Abnormal drinking behavior (HP:0030082)1.94014060
92Medial flaring of the eyebrow (HP:0010747)1.93454558
93Abnormality of the lower motor neuron (HP:0002366)1.93369791
94Gaze-evoked nystagmus (HP:0000640)1.92957738
95Amblyopia (HP:0000646)1.92416496
96Poor eye contact (HP:0000817)1.91455035
97Male pseudohermaphroditism (HP:0000037)1.90746262
98Chronic hepatic failure (HP:0100626)1.90719076
99Limb dystonia (HP:0002451)1.90326642
100Optic nerve hypoplasia (HP:0000609)1.89071331
101Increased corneal curvature (HP:0100692)1.88064082
102Keratoconus (HP:0000563)1.88064082
103Goiter (HP:0000853)1.87720585
104Aqueductal stenosis (HP:0002410)1.87239980
105Resting tremor (HP:0002322)1.87079091
106Genital tract atresia (HP:0001827)1.86355138
107Acute necrotizing encephalopathy (HP:0006965)1.85313093
108Dysdiadochokinesis (HP:0002075)1.85236092
109Vaginal atresia (HP:0000148)1.84595601
110Hyperthyroidism (HP:0000836)1.84552677
111Polyphagia (HP:0002591)1.84420961
112Sclerocornea (HP:0000647)1.83418052
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81797776
114Aplasia/hypoplasia of the uterus (HP:0008684)1.81433956
115Enlarged penis (HP:0000040)1.81154064
116Abnormal pancreas size (HP:0012094)1.80616567
117Labial hypoplasia (HP:0000066)1.80513142
118Late onset (HP:0003584)1.80057605
119Lissencephaly (HP:0001339)1.78932447
120Congenital sensorineural hearing impairment (HP:0008527)1.77987265
121Abnormal social behavior (HP:0012433)1.77852209
122Impaired social interactions (HP:0000735)1.77852209
123Genetic anticipation (HP:0003743)1.77718022
124Obsessive-compulsive behavior (HP:0000722)1.77478946
125Hematochezia (HP:0002573)1.77353929
126Menstrual irregularities (HP:0000858)1.76778642
127Ankyloglossia (HP:0010296)1.76555455
128Cortical visual impairment (HP:0100704)1.76485280
129Thyroid-stimulating hormone excess (HP:0002925)1.76132852
130Colon cancer (HP:0003003)1.75883517
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.75765757
132Specific learning disability (HP:0001328)1.75535209
133Abnormality of salivation (HP:0100755)1.74417252
134Hepatoblastoma (HP:0002884)1.74349467
135Abnormality of macular pigmentation (HP:0008002)1.73908802
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.73779134
137Hypoplasia of the fovea (HP:0007750)1.73779134
138Impaired vibration sensation in the lower limbs (HP:0002166)1.73330556
139* Impaired smooth pursuit (HP:0007772)1.72835216
140Truncal obesity (HP:0001956)1.72736765
141Chorioretinal atrophy (HP:0000533)1.71865718
142Abnormality of the labia minora (HP:0012880)1.71729188
143Large for gestational age (HP:0001520)1.71618377
144Severe muscular hypotonia (HP:0006829)1.71158905
145Gastrointestinal atresia (HP:0002589)1.69894742
146Neoplasm of the heart (HP:0100544)1.69722912
147Increased circulating renin level (HP:0000848)1.69143953
148Hypokalemia (HP:0002900)1.68843093
149Neuroendocrine neoplasm (HP:0100634)1.68171191
150Aplasia/Hypoplasia of the spleen (HP:0010451)1.68100741
151Thyroid carcinoma (HP:0002890)1.65546159
152Restlessness (HP:0000711)1.65249989
153Hypochromic microcytic anemia (HP:0004840)1.64982497
154Gastroesophageal reflux (HP:0002020)1.64929744
155Intestinal atresia (HP:0011100)1.64373081
156Bradykinesia (HP:0002067)1.64261645
157Postural tremor (HP:0002174)1.63788160
158Bifid tongue (HP:0010297)1.62743169
159Anteriorly placed anus (HP:0001545)1.59328758
160Postural instability (HP:0002172)1.58993094
161Hypoplastic female external genitalia (HP:0012815)1.58009687
162Urinary bladder sphincter dysfunction (HP:0002839)1.57450463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.37862431
2MARK13.36216665
3INSRR3.28153638
4MAP3K42.96539205
5MAP3K92.57627459
6WNK32.49858726
7PRKD32.43325147
8ADRBK22.40658844
9CASK2.39047148
10GRK12.38613701
11EPHA42.36378095
12MAP3K22.16804982
13PINK12.06177662
14MAP4K22.04595959
15PASK2.02561588
16MAP2K72.01716839
17TRIM281.89105590
18MINK11.87552923
19UHMK11.87410959
20AKT31.84491565
21PNCK1.74829478
22NTRK11.73553154
23NTRK21.73235587
24BMPR1B1.73215638
25KSR11.67310962
26SCYL21.59082406
27NUAK11.55302872
28HIPK21.50913244
29MAP2K41.49485518
30ZAK1.46526185
31MAPK131.45967699
32DAPK21.45685011
33CSNK1G11.43643317
34CAMKK21.43565501
35FRK1.38142151
36CDC42BPA1.35366183
37BRD41.33215107
38PAK61.30704684
39MST41.25839195
40OXSR11.24641547
41CDK51.22537859
42STK391.18079584
43CSNK1G31.17599117
44WNK41.17144041
45KSR21.16286829
46SGK2231.15464948
47SGK4941.15464948
48SGK21.14796295
49GRK51.11715555
50DAPK11.06673911
51MKNK21.04528370
52CAMKK11.03070398
53ERBB31.01666800
54BCR1.00110726
55ACVR1B0.99316165
56DYRK1A0.97797720
57PLK20.97250028
58MAPK150.97177391
59NLK0.96688897
60RET0.95837077
61CDK120.95738122
62WNK10.94397091
63PDGFRA0.93959937
64PRKCG0.90353984
65SIK20.87243307
66PAK30.86658660
67TLK10.85572943
68TAOK30.85162730
69CAMK1G0.81535454
70SGK30.81498862
71EPHA30.79304214
72SGK10.76628171
73CDK30.75384245
74PRKCH0.75176379
75DYRK20.74956964
76BRSK10.74630681
77BCKDK0.74535275
78PLK30.74107118
79TNIK0.71704218
80STK38L0.70966698
81CAMK2A0.70730347
82CAMK2B0.70495061
83CSNK1G20.69514231
84BRAF0.65153766
85STK160.64933191
86MAP2K60.60360622
87FGFR20.59428152
88STK110.59385739
89CSNK1A10.59149493
90MAP3K10.58131064
91VRK10.57415627
92CDC70.57293939
93MAPK100.57196623
94MAP3K120.56707598
95PTK20.56601809
96MARK20.54123684
97RPS6KA30.53938908
98CDK140.53924994
99DYRK1B0.53046518
100PLK40.52556684
101STK380.52531097
102TYRO30.52133112
103PTK2B0.51706038
104PRKAA10.51467081
105PRKACA0.51398645
106YES10.51273171
107PRPF4B0.51099160
108PRKDC0.50546464
109ALK0.50245722
110CAMK2D0.49936519
111PRKCE0.49476294
112CSNK1E0.49442752
113CDK180.49170558
114GSK3B0.48321341
115FER0.47682032
116ADRBK10.46625245
117SIK30.46197570
118PRKCZ0.46142592
119PHKG10.44361607
120PHKG20.44361607
121CSNK1A1L0.44255629
122CDK150.44130600
123PLK10.44093396
124CSNK1D0.43041776
125PKN10.42551738
126MELK0.42032133
127BMPR20.41838658
128RPS6KA20.41730521
129PRKD20.41572316
130TIE10.41496670
131MAPK140.41123095
132FGFR30.41041822
133PRKCB0.40544807
134RPS6KB10.38453893
135CDK10.37385218
136PRKAA20.36274288
137ATM0.35338005
138STK30.34953166
139PRKCA0.34674505
140LIMK10.34360917
141BRSK20.34129872
142RPS6KA50.33433753
143PRKG10.32888632
144PRKACB0.32128839
145CAMK10.32011896
146DYRK30.31218273
147TEC0.29451927
148ABL10.27320320

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.60352070
2Insulin secretion_Homo sapiens_hsa049113.03507344
3Nicotine addiction_Homo sapiens_hsa050332.87818910
4Synaptic vesicle cycle_Homo sapiens_hsa047212.61268517
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55600509
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44793259
7Amphetamine addiction_Homo sapiens_hsa050312.38242879
8GABAergic synapse_Homo sapiens_hsa047272.37788432
9Circadian entrainment_Homo sapiens_hsa047132.32219907
10Long-term potentiation_Homo sapiens_hsa047202.31378516
11Butanoate metabolism_Homo sapiens_hsa006502.23221856
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22963254
13Phototransduction_Homo sapiens_hsa047442.21806943
14Type II diabetes mellitus_Homo sapiens_hsa049302.16216051
15Dopaminergic synapse_Homo sapiens_hsa047282.15169221
16Morphine addiction_Homo sapiens_hsa050322.11828471
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03565483
18Oxidative phosphorylation_Homo sapiens_hsa001902.02266591
19Glutamatergic synapse_Homo sapiens_hsa047242.01753909
20Cocaine addiction_Homo sapiens_hsa050302.00880489
21Selenocompound metabolism_Homo sapiens_hsa004501.95771944
22Olfactory transduction_Homo sapiens_hsa047401.95032970
23Taste transduction_Homo sapiens_hsa047421.85478723
24Cholinergic synapse_Homo sapiens_hsa047251.78408367
25Serotonergic synapse_Homo sapiens_hsa047261.77761353
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70077221
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63525660
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60982028
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52240503
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48148987
31Long-term depression_Homo sapiens_hsa047301.46452345
32Salivary secretion_Homo sapiens_hsa049701.43395902
33Renin secretion_Homo sapiens_hsa049241.42275679
34Vibrio cholerae infection_Homo sapiens_hsa051101.42231418
35Tryptophan metabolism_Homo sapiens_hsa003801.35956262
36Collecting duct acid secretion_Homo sapiens_hsa049661.35791597
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33138674
38Basal transcription factors_Homo sapiens_hsa030221.32565144
39Circadian rhythm_Homo sapiens_hsa047101.31306497
40Alcoholism_Homo sapiens_hsa050341.28889806
41GnRH signaling pathway_Homo sapiens_hsa049121.28805452
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27166909
43Parkinsons disease_Homo sapiens_hsa050121.26325014
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26016487
45Protein export_Homo sapiens_hsa030601.23902520
46Type I diabetes mellitus_Homo sapiens_hsa049401.23198169
47RNA polymerase_Homo sapiens_hsa030201.22579342
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21595782
49Homologous recombination_Homo sapiens_hsa034401.18764794
50Gastric acid secretion_Homo sapiens_hsa049711.18276846
51Oxytocin signaling pathway_Homo sapiens_hsa049211.18170175
52Estrogen signaling pathway_Homo sapiens_hsa049151.18087907
53Gap junction_Homo sapiens_hsa045401.17855639
54Vitamin B6 metabolism_Homo sapiens_hsa007501.16837370
55Thyroid hormone synthesis_Homo sapiens_hsa049181.16750076
56Propanoate metabolism_Homo sapiens_hsa006401.14358675
57Linoleic acid metabolism_Homo sapiens_hsa005911.13602015
58Ether lipid metabolism_Homo sapiens_hsa005651.13158893
59RNA degradation_Homo sapiens_hsa030181.12467626
60Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12463150
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12259204
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11922780
63Nitrogen metabolism_Homo sapiens_hsa009101.11747840
64Oocyte meiosis_Homo sapiens_hsa041141.10079656
65Dorso-ventral axis formation_Homo sapiens_hsa043201.07732003
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07132628
67cAMP signaling pathway_Homo sapiens_hsa040241.01553581
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01507046
69Glucagon signaling pathway_Homo sapiens_hsa049221.00811049
70Pancreatic secretion_Homo sapiens_hsa049721.00206071
71Calcium signaling pathway_Homo sapiens_hsa040201.00086627
72Fatty acid elongation_Homo sapiens_hsa000620.99746636
73Peroxisome_Homo sapiens_hsa041460.99736643
74Melanogenesis_Homo sapiens_hsa049160.98108948
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97846709
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96523827
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95185163
78Glioma_Homo sapiens_hsa052140.94524393
79ErbB signaling pathway_Homo sapiens_hsa040120.93034933
80Alzheimers disease_Homo sapiens_hsa050100.92560749
81Fanconi anemia pathway_Homo sapiens_hsa034600.91353150
82Caffeine metabolism_Homo sapiens_hsa002320.90833044
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90416794
84mTOR signaling pathway_Homo sapiens_hsa041500.88962811
85Axon guidance_Homo sapiens_hsa043600.88300610
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86940861
87Retinol metabolism_Homo sapiens_hsa008300.84511417
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.84073027
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.82528564
90Steroid biosynthesis_Homo sapiens_hsa001000.80643194
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78732775
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78149008
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77002980
94Huntingtons disease_Homo sapiens_hsa050160.75052863
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73048416
96Chemical carcinogenesis_Homo sapiens_hsa052040.72926608
97Non-homologous end-joining_Homo sapiens_hsa034500.72595976
98Wnt signaling pathway_Homo sapiens_hsa043100.70902118
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70578274
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69165031
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68446482
102Endometrial cancer_Homo sapiens_hsa052130.67999835
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67130262
104Inositol phosphate metabolism_Homo sapiens_hsa005620.65460308
105Ovarian steroidogenesis_Homo sapiens_hsa049130.64402420
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.64268945
107N-Glycan biosynthesis_Homo sapiens_hsa005100.63647932
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63569366
109Fatty acid metabolism_Homo sapiens_hsa012120.61981880
110ABC transporters_Homo sapiens_hsa020100.61970811
111Insulin signaling pathway_Homo sapiens_hsa049100.61755461
112Purine metabolism_Homo sapiens_hsa002300.60563698
113Prolactin signaling pathway_Homo sapiens_hsa049170.60351193
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60187416
115MAPK signaling pathway_Homo sapiens_hsa040100.59714118
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59426832
117Choline metabolism in cancer_Homo sapiens_hsa052310.58464715
118One carbon pool by folate_Homo sapiens_hsa006700.58181581
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58117332
120beta-Alanine metabolism_Homo sapiens_hsa004100.56934476
121Folate biosynthesis_Homo sapiens_hsa007900.56395334
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56089915
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.55875858
124Hedgehog signaling pathway_Homo sapiens_hsa043400.54850333
125Metabolic pathways_Homo sapiens_hsa011000.52800582
126mRNA surveillance pathway_Homo sapiens_hsa030150.47925788
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47717001
128Ras signaling pathway_Homo sapiens_hsa040140.47461247
129Renal cell carcinoma_Homo sapiens_hsa052110.46791386
130Dilated cardiomyopathy_Homo sapiens_hsa054140.46595832
131Fatty acid degradation_Homo sapiens_hsa000710.46487554
132Regulation of autophagy_Homo sapiens_hsa041400.45592923
133Sulfur metabolism_Homo sapiens_hsa009200.45568631
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45297150
135Prion diseases_Homo sapiens_hsa050200.44611500
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44156894
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.43990449
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42462727
139AMPK signaling pathway_Homo sapiens_hsa041520.42331843
140Mineral absorption_Homo sapiens_hsa049780.41410662
141Colorectal cancer_Homo sapiens_hsa052100.41256697
142Glycerolipid metabolism_Homo sapiens_hsa005610.39840206
143Cardiac muscle contraction_Homo sapiens_hsa042600.39521425
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39480150
145Fat digestion and absorption_Homo sapiens_hsa049750.38746585
146Starch and sucrose metabolism_Homo sapiens_hsa005000.38063662
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37150505
148Non-small cell lung cancer_Homo sapiens_hsa052230.36803529
149FoxO signaling pathway_Homo sapiens_hsa040680.36386113
150Melanoma_Homo sapiens_hsa052180.35396806
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35150482
152Insulin resistance_Homo sapiens_hsa049310.33083595
153Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30372659
154Hippo signaling pathway_Homo sapiens_hsa043900.29481041
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27967950
156Rap1 signaling pathway_Homo sapiens_hsa040150.27555847

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