SYT15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Synaptotagmin (Syt) family of membrane trafficking proteins. Members of this family contain a transmembrane region and a C-terminal-type tandem C2 domain. Unlike related family members, the encoded protein may be involved in membrane trafficking in non-neuronal tissues. Two trancript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)4.96230375
2regulation of hippo signaling (GO:0035330)4.67069277
3behavioral response to nicotine (GO:0035095)4.37132522
4polyketide metabolic process (GO:0030638)3.96594066
5doxorubicin metabolic process (GO:0044598)3.96594066
6daunorubicin metabolic process (GO:0044597)3.96594066
7detection of molecule of bacterial origin (GO:0032490)3.94339514
8negative regulation of mast cell activation (GO:0033004)3.90297204
9lymph vessel development (GO:0001945)3.85875274
10L-fucose catabolic process (GO:0042355)3.78113777
11fucose catabolic process (GO:0019317)3.78113777
12L-fucose metabolic process (GO:0042354)3.78113777
13lymphangiogenesis (GO:0001946)3.75385636
14positive regulation of cellular amide metabolic process (GO:0034250)3.53402727
15indole-containing compound catabolic process (GO:0042436)3.49518660
16indolalkylamine catabolic process (GO:0046218)3.49518660
17tryptophan catabolic process (GO:0006569)3.49518660
18ganglion development (GO:0061548)3.42590764
19protein K11-linked deubiquitination (GO:0035871)3.42262997
20facial nerve structural organization (GO:0021612)3.41029739
21gamma-aminobutyric acid transport (GO:0015812)3.37299400
22detection of light stimulus involved in sensory perception (GO:0050962)3.37106069
23detection of light stimulus involved in visual perception (GO:0050908)3.37106069
24indolalkylamine metabolic process (GO:0006586)3.36159471
25regulation of activation of Janus kinase activity (GO:0010533)3.34230916
26kynurenine metabolic process (GO:0070189)3.27068845
27positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.26517372
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25059482
29regulation of action potential (GO:0098900)3.22374872
30tachykinin receptor signaling pathway (GO:0007217)3.20452232
31cellular ketone body metabolic process (GO:0046950)3.20257304
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19198045
33monoubiquitinated protein deubiquitination (GO:0035520)3.15758517
34tryptophan metabolic process (GO:0006568)3.11631006
35ceramide catabolic process (GO:0046514)3.10240142
36reflex (GO:0060004)3.06705260
37regulation of interleukin-8 secretion (GO:2000482)3.03330582
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.01880467
39regulation of translation, ncRNA-mediated (GO:0045974)3.01880467
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01880467
41dendritic cell chemotaxis (GO:0002407)3.00947060
42detection of external biotic stimulus (GO:0098581)3.00790806
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99108373
44positive regulation of uterine smooth muscle contraction (GO:0070474)2.96333297
45photoreceptor cell maintenance (GO:0045494)2.95638731
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95169144
47energy homeostasis (GO:0097009)2.94895210
48retina vasculature morphogenesis in camera-type eye (GO:0061299)2.93424965
49auditory receptor cell stereocilium organization (GO:0060088)2.93125125
50negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92587531
51transepithelial transport (GO:0070633)2.90260056
52polyol transport (GO:0015791)2.89920000
53cranial nerve structural organization (GO:0021604)2.88665460
54inner ear receptor stereocilium organization (GO:0060122)2.88255140
55positive regulation of action potential (GO:0045760)2.85313045
56behavioral response to ethanol (GO:0048149)2.85177398
57cornea development in camera-type eye (GO:0061303)2.84768038
58neural tube formation (GO:0001841)2.84244594
59replicative senescence (GO:0090399)2.83832166
60platelet dense granule organization (GO:0060155)2.83478588
61positive regulation of protein kinase C signaling (GO:0090037)2.83210386
62neuronal action potential (GO:0019228)2.83142011
63membrane depolarization during action potential (GO:0086010)2.82282901
64detection of other organism (GO:0098543)2.81761895
65nucleotide transmembrane transport (GO:1901679)2.81075456
66mesenchymal cell differentiation involved in kidney development (GO:0072161)2.79762913
67mesenchymal cell differentiation involved in renal system development (GO:2001012)2.79762913
68indole-containing compound metabolic process (GO:0042430)2.79676728
69regulation of cellular extravasation (GO:0002691)2.79262787
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76907184
71response to host immune response (GO:0052572)2.76907184
72sulfate transport (GO:0008272)2.75661210
73ketone body metabolic process (GO:1902224)2.75592567
74centriole assembly (GO:0098534)2.73648174
75negative regulation of myoblast differentiation (GO:0045662)2.68616786
76chemical homeostasis within a tissue (GO:0048875)2.68529080
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.68045520
78interkinetic nuclear migration (GO:0022027)2.67805623
79detection of bacterium (GO:0016045)2.67617416
80establishment of protein localization to Golgi (GO:0072600)2.66289870
81regulation of sarcomere organization (GO:0060297)2.65804772
82cellular anion homeostasis (GO:0030002)2.65376642
83serotonin metabolic process (GO:0042428)2.65333911
84superoxide metabolic process (GO:0006801)2.65003982
85adenine nucleotide transport (GO:0051503)2.64848791
86sulfate transmembrane transport (GO:1902358)2.63798966
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62606341
88regulation of antigen processing and presentation (GO:0002577)2.61921418
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61432188
90positive regulation of heat generation (GO:0031652)2.60257483
91response to pheromone (GO:0019236)2.58319981
92sulfation (GO:0051923)2.58254682
93retinal cone cell development (GO:0046549)2.57808542
94cell differentiation involved in metanephros development (GO:0072202)2.57767860
95regulation of uterine smooth muscle contraction (GO:0070472)2.57425580
96primary amino compound metabolic process (GO:1901160)2.57278565
97positive regulation of antigen processing and presentation (GO:0002579)2.57265950
98nonmotile primary cilium assembly (GO:0035058)2.56615799
99phosphatidylinositol acyl-chain remodeling (GO:0036149)2.54480664
100sprouting angiogenesis (GO:0002040)2.54247399
101amine catabolic process (GO:0009310)2.54115553
102cellular biogenic amine catabolic process (GO:0042402)2.54115553
103adaptation of signaling pathway (GO:0023058)2.53900598
104water-soluble vitamin biosynthetic process (GO:0042364)2.53478186
105positive regulation of digestive system process (GO:0060456)2.53323215
106positive regulation by symbiont of host defense response (GO:0052509)2.52969188
107modulation by symbiont of host defense response (GO:0052031)2.52969188
108modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52969188
109modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52969188
110positive regulation by organism of defense response of other organism involved in symbiotic interact2.52969188
111modulation by symbiont of host immune response (GO:0052553)2.52969188
112positive regulation of developmental pigmentation (GO:0048087)2.52676952
113negative regulation of homotypic cell-cell adhesion (GO:0034111)2.51234255
114natural killer cell activation involved in immune response (GO:0002323)2.50639850
115regulation of platelet aggregation (GO:0090330)2.50188084
116thyroid hormone metabolic process (GO:0042403)2.49306654
117preassembly of GPI anchor in ER membrane (GO:0016254)2.49111000
118benzene-containing compound metabolic process (GO:0042537)2.48694324
119glycolipid catabolic process (GO:0019377)2.48464555
120negative regulation of nitric-oxide synthase activity (GO:0051001)2.48044642
121detection of biotic stimulus (GO:0009595)2.47780754
122protein localization to cilium (GO:0061512)2.46450154
123kidney morphogenesis (GO:0060993)2.46105704
124cellular response to ATP (GO:0071318)2.44992309
125histamine secretion (GO:0001821)2.44861448
126urinary tract smooth muscle contraction (GO:0014848)2.44694602
127signal peptide processing (GO:0006465)2.44530604
128nephron epithelium morphogenesis (GO:0072088)2.44363952
129nephron tubule morphogenesis (GO:0072078)2.44363952
130DNA deamination (GO:0045006)2.44188064
131dendritic cell migration (GO:0036336)2.43106952
132proline transport (GO:0015824)2.42878835
133dentate gyrus development (GO:0021542)2.42813789
134surfactant homeostasis (GO:0043129)2.42575361
135extracellular negative regulation of signal transduction (GO:1900116)2.42292129
136extracellular regulation of signal transduction (GO:1900115)2.42292129
137nucleotide transport (GO:0006862)2.41866975
138startle response (GO:0001964)2.40015386
139female gonad development (GO:0008585)2.39633536
140response to peptidoglycan (GO:0032494)2.39255363
141positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.39149046
142glycosphingolipid biosynthetic process (GO:0006688)2.39079582
143G-protein coupled receptor internalization (GO:0002031)2.38466976
144negative regulation of complement activation (GO:0045916)2.38062749
145adenosine metabolic process (GO:0046085)2.37882617
146lateral ventricle development (GO:0021670)2.37720061
147axoneme assembly (GO:0035082)2.37524305
148negative regulation of protein localization to cell surface (GO:2000009)2.37169507
149cyclic nucleotide catabolic process (GO:0009214)2.36936416
150venous blood vessel morphogenesis (GO:0048845)2.36601628
151cellular response to sterol (GO:0036315)2.36164927
152tyrosine phosphorylation of STAT protein (GO:0007260)2.35021323
153G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.34918625
154cilium morphogenesis (GO:0060271)2.34716944
155leukocyte tethering or rolling (GO:0050901)2.34291554
156negative regulation of systemic arterial blood pressure (GO:0003085)2.33498341
157regulation of pigment cell differentiation (GO:0050932)2.33451561
158cytoplasmic mRNA processing body assembly (GO:0033962)2.32905743
159phosphatidylserine acyl-chain remodeling (GO:0036150)2.32843151
160piRNA metabolic process (GO:0034587)2.32630353
161response to type I interferon (GO:0034340)2.32607505
162detection of mechanical stimulus involved in sensory perception (GO:0050974)2.32100637
163negative regulation of granulocyte differentiation (GO:0030853)2.31769593
164positive regulation of CREB transcription factor activity (GO:0032793)2.31591581
165photoreceptor cell development (GO:0042461)2.31457956
166positive regulation of phosphatase activity (GO:0010922)2.31120986
167regulation of neurotransmitter uptake (GO:0051580)2.29937949
168opioid receptor signaling pathway (GO:0038003)2.29921692
169negative regulation of keratinocyte proliferation (GO:0010839)2.29588876
170NAD biosynthetic process (GO:0009435)2.28866120
171negative regulation of Rho protein signal transduction (GO:0035024)2.28522262
172regulation of male gonad development (GO:2000018)2.28491511
173histone H3-K9 methylation (GO:0051567)2.28275111
174cilium organization (GO:0044782)2.28142409
175purinergic nucleotide receptor signaling pathway (GO:0035590)2.28083924
176positive regulation of interleukin-1 beta secretion (GO:0050718)2.27967313
177cilium or flagellum-dependent cell motility (GO:0001539)2.27927760
178cellular response to type I interferon (GO:0071357)2.27459033
179type I interferon signaling pathway (GO:0060337)2.27459033
180positive regulation of smooth muscle cell migration (GO:0014911)2.26956682
181DNA integration (GO:0015074)2.26954240
182peristalsis (GO:0030432)2.26221329
183sphingoid metabolic process (GO:0046519)2.25243006
184response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25130632
185response to host (GO:0075136)2.25130632
186response to host defenses (GO:0052200)2.25130632
187dopamine transport (GO:0015872)2.25010055
188cAMP catabolic process (GO:0006198)2.24734343
189glycosphingolipid catabolic process (GO:0046479)2.22704549
190lipoxygenase pathway (GO:0019372)2.22429352
191negative regulation of leukocyte chemotaxis (GO:0002689)2.22345650
192motile cilium assembly (GO:0044458)2.21940237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.10279705
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.95396196
3ZNF274_21170338_ChIP-Seq_K562_Hela3.19771059
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88219778
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.68573113
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64264894
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58372807
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.56794608
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42619923
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.17093690
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.15761247
12FUS_26573619_Chip-Seq_HEK293_Human2.15448415
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10961755
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10770869
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05962566
16TAF15_26573619_Chip-Seq_HEK293_Human2.05492682
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.03347051
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.02173114
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92787086
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.90874187
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88844293
22EZH2_22144423_ChIP-Seq_EOC_Human1.86274052
23EWS_26573619_Chip-Seq_HEK293_Human1.86200527
24EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.85498378
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.82842923
26STAT3_18555785_Chip-Seq_ESCs_Mouse1.80330375
27E2F1_18555785_Chip-Seq_ESCs_Mouse1.79750538
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.78808506
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78067559
30P53_22387025_ChIP-Seq_ESCs_Mouse1.74860481
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74533873
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72177525
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71872540
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70456026
35NMYC_18555785_Chip-Seq_ESCs_Mouse1.69515931
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66031414
37P300_19829295_ChIP-Seq_ESCs_Human1.64505555
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64397690
39P300_18555785_Chip-Seq_ESCs_Mouse1.63912585
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63823016
41AR_25329375_ChIP-Seq_VCAP_Human1.62335294
42ZFX_18555785_Chip-Seq_ESCs_Mouse1.60050541
43EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.59583623
44SOX2_18555785_Chip-Seq_ESCs_Mouse1.58386213
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58274504
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.58168241
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.58139737
48BCAT_22108803_ChIP-Seq_LS180_Human1.57394650
49PU1_27457419_Chip-Seq_LIVER_Mouse1.57195556
50RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56881266
51AR_21572438_ChIP-Seq_LNCaP_Human1.56862014
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56750300
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56081461
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.54820109
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52638940
56DROSHA_22980978_ChIP-Seq_HELA_Human1.52589377
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.50822487
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.50361595
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49275828
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.47955730
61ESRRB_18555785_Chip-Seq_ESCs_Mouse1.46723268
62TP53_16413492_ChIP-PET_HCT116_Human1.45996972
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44791791
64CBP_20019798_ChIP-Seq_JUKART_Human1.44791791
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40483699
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40453571
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40279881
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40048730
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40038897
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39927314
71AHR_22903824_ChIP-Seq_MCF-7_Human1.39174738
72SMAD4_21799915_ChIP-Seq_A2780_Human1.38774639
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38404666
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.38209604
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35697327
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35213763
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.34297919
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32906378
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.32260188
80SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31722315
81IGF1R_20145208_ChIP-Seq_DFB_Human1.31355216
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30746761
83TP53_18474530_ChIP-ChIP_U2OS_Human1.30700752
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.30408692
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29632017
86NANOG_19829295_ChIP-Seq_ESCs_Human1.29042305
87SOX2_19829295_ChIP-Seq_ESCs_Human1.29042305
88TCF4_22108803_ChIP-Seq_LS180_Human1.28667593
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28224600
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.27994235
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.27549169
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27264304
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.26894656
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.26678199
95RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26616052
96EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26616052
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26517584
98OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26133986
99RUNX2_22187159_ChIP-Seq_PCA_Human1.25905170
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.24415465
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.23732198
102* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23432913
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21549699
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21446729
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21229680
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21229680
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19804060
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19354958
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19281292
110KDM2B_26808549_Chip-Seq_REH_Human1.19200876
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17767070
112RNF2_27304074_Chip-Seq_NSC_Mouse1.17495405
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16879514
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16421044
115STAT3_23295773_ChIP-Seq_U87_Human1.16309694
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14833562
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13788104
118CDX2_22108803_ChIP-Seq_LS180_Human1.13645862
119ER_23166858_ChIP-Seq_MCF-7_Human1.13499488
120REST_21632747_ChIP-Seq_MESCs_Mouse1.12946370
121VDR_22108803_ChIP-Seq_LS180_Human1.12738901
122TCF4_23295773_ChIP-Seq_U87_Human1.12032953
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.11858075
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11191394
125RXR_22108803_ChIP-Seq_LS180_Human1.11191336
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10829490
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10283980
128TP53_22573176_ChIP-Seq_HFKS_Human1.09336474
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09247077
130SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08759097
131SOX2_21211035_ChIP-Seq_LN229_Gbm1.08432654
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08169138
133IRF1_19129219_ChIP-ChIP_H3396_Human1.07862174
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07670598
135* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06314445
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06124300
137FOXA1_25329375_ChIP-Seq_VCAP_Human1.06114469
138FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06114469
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05528099
140FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05520502
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04143000
142SMAD3_21741376_ChIP-Seq_EPCs_Human1.04000364
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03792737
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03586934
145STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01156410
146GATA3_21878914_ChIP-Seq_MCF-7_Human1.01063644
147NOTCH1_21737748_ChIP-Seq_TLL_Human1.00429778
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99914269
149GATA1_22025678_ChIP-Seq_K562_Human0.99087086
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98511864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.35567135
2MP0000566_synostosis3.91243989
3MP0001188_hyperpigmentation3.65475479
4MP0008004_abnormal_stomach_pH3.33546191
5MP0010368_abnormal_lymphatic_system3.21902595
6MP0000569_abnormal_digit_pigmentation3.11247562
7MP0001879_abnormal_lymphatic_vessel3.01986412
8MP0001968_abnormal_touch/_nociception2.91660859
9MP0005171_absent_coat_pigmentation2.82168805
10MP0005409_darkened_coat_color2.69419458
11MP0006292_abnormal_olfactory_placode2.67841264
12MP0002277_abnormal_respiratory_mucosa2.62981749
13MP0009697_abnormal_copulation2.45777438
14MP0002148_abnormal_hypersensitivity_rea2.40112505
15MP0003136_yellow_coat_color2.31091256
16MP0002837_dystrophic_cardiac_calcinosis2.28814696
17MP0008872_abnormal_physiological_respon2.25983787
18MP0005645_abnormal_hypothalamus_physiol2.15741310
19MP0001501_abnormal_sleep_pattern2.13683003
20MP0009046_muscle_twitch2.11461072
21MP0001986_abnormal_taste_sensitivity2.06892635
22MP0010386_abnormal_urinary_bladder2.06324241
23MP0002138_abnormal_hepatobiliary_system2.05507773
24MP0002736_abnormal_nociception_after2.04955621
25MP0003941_abnormal_skin_development2.01858987
26MP0005174_abnormal_tail_pigmentation2.01530633
27MP0009745_abnormal_behavioral_response1.99833425
28MP0008995_early_reproductive_senescence1.98574180
29MP0004782_abnormal_surfactant_physiolog1.98301510
30MP0009780_abnormal_chondrocyte_physiolo1.96252868
31MP0002876_abnormal_thyroid_physiology1.95655055
32MP0004215_abnormal_myocardial_fiber1.92323421
33MP0008875_abnormal_xenobiotic_pharmacok1.89152886
34MP0003950_abnormal_plasma_membrane1.84795726
35MP0005646_abnormal_pituitary_gland1.84075094
36MP0001835_abnormal_antigen_presentation1.83194069
37MP0002638_abnormal_pupillary_reflex1.82445154
38MP0004043_abnormal_pH_regulation1.80361920
39MP0003787_abnormal_imprinting1.80361090
40MP0008775_abnormal_heart_ventricle1.79523176
41MP0000678_abnormal_parathyroid_gland1.79445741
42MP0000427_abnormal_hair_cycle1.79360353
43MP0008877_abnormal_DNA_methylation1.72820284
44MP0003646_muscle_fatigue1.72501736
45MP0009764_decreased_sensitivity_to1.71921847
46MP0000015_abnormal_ear_pigmentation1.70003268
47MP0002272_abnormal_nervous_system1.68362981
48MP0004084_abnormal_cardiac_muscle1.67555468
49MP0005670_abnormal_white_adipose1.63583321
50MP0006072_abnormal_retinal_apoptosis1.63208542
51MP0001485_abnormal_pinna_reflex1.59586493
52MP0001502_abnormal_circadian_rhythm1.52329103
53MP0002132_abnormal_respiratory_system1.51391510
54MP0000383_abnormal_hair_follicle1.51149255
55MP0009785_altered_susceptibility_to1.48655380
56MP0004145_abnormal_muscle_electrophysio1.47026100
57MP0002572_abnormal_emotion/affect_behav1.45256774
58MP0006276_abnormal_autonomic_nervous1.43881526
59MP0004885_abnormal_endolymph1.43519686
60MP0001790_abnormal_immune_system1.39296507
61MP0005387_immune_system_phenotype1.39296507
62MP0003195_calcinosis1.38049789
63MP0000230_abnormal_systemic_arterial1.36694839
64MP0004085_abnormal_heartbeat1.35000106
65MP0002733_abnormal_thermal_nociception1.33768725
66MP0002102_abnormal_ear_morphology1.31971411
67MP0005084_abnormal_gallbladder_morpholo1.31180018
68MP0002064_seizures1.30209695
69MP0004742_abnormal_vestibular_system1.29715958
70MP0003137_abnormal_impulse_conducting1.27375080
71MP0002419_abnormal_innate_immunity1.26141790
72MP0003868_abnormal_feces_composition1.25957185
73MP0003635_abnormal_synaptic_transmissio1.25547555
74MP0002557_abnormal_social/conspecific_i1.24988222
75MP0000372_irregular_coat_pigmentation1.23449791
76MP0005671_abnormal_response_to1.23236320
77MP0000631_abnormal_neuroendocrine_gland1.22835073
78MP0004484_altered_response_of1.22489633
79MP0005167_abnormal_blood-brain_barrier1.21564020
80MP0001970_abnormal_pain_threshold1.21225400
81MP0004924_abnormal_behavior1.19026416
82MP0005386_behavior/neurological_phenoty1.19026416
83MP0001851_eye_inflammation1.18251265
84MP0002063_abnormal_learning/memory/cond1.17625319
85MP0003828_pulmonary_edema1.16640014
86MP0002653_abnormal_ependyma_morphology1.15639408
87MP0002067_abnormal_sensory_capabilities1.15611680
88MP0002928_abnormal_bile_duct1.15087353
89MP0000681_abnormal_thyroid_gland1.14321609
90MP0008058_abnormal_DNA_repair1.12674783
91MP0003045_fibrosis1.12553054
92MP0004130_abnormal_muscle_cell1.12504603
93MP0009384_cardiac_valve_regurgitation1.10161858
94MP0008260_abnormal_autophagy1.09523924
95MP0005647_abnormal_sex_gland1.06199739
96MP0004019_abnormal_vitamin_homeostasis1.05791649
97MP0010155_abnormal_intestine_physiology1.05064490
98MP0001984_abnormal_olfaction1.04687755
99MP0005310_abnormal_salivary_gland0.99703865
100MP0005551_abnormal_eye_electrophysiolog0.99700346
101MP0003880_abnormal_central_pattern0.99683807
102MP0002735_abnormal_chemical_nociception0.98234792
103MP0005025_abnormal_response_to0.97974224
104MP0005379_endocrine/exocrine_gland_phen0.97249503
105MP0002693_abnormal_pancreas_physiology0.96250546
106MP0004036_abnormal_muscle_relaxation0.95298136
107MP0004147_increased_porphyrin_level0.94155800
108MP0005195_abnormal_posterior_eye0.93612552
109MP0002938_white_spotting0.93427954
110MP0005000_abnormal_immune_tolerance0.92010502
111MP0005253_abnormal_eye_physiology0.89689365
112MP0010329_abnormal_lipoprotein_level0.89402283
113MP0002734_abnormal_mechanical_nocicepti0.89008077
114MP0004133_heterotaxia0.86297189
115MP0005503_abnormal_tendon_morphology0.86282250
116MP0001664_abnormal_digestion0.86005415
117MP0001756_abnormal_urination0.85468696
118MP0000026_abnormal_inner_ear0.85311146
119MP0002184_abnormal_innervation0.83933659
120MP0001440_abnormal_grooming_behavior0.83832599
121MP0002229_neurodegeneration0.83499094
122MP0006054_spinal_hemorrhage0.83252486
123MP0000613_abnormal_salivary_gland0.82258298
124MP0001186_pigmentation_phenotype0.82077991
125MP0002998_abnormal_bone_remodeling0.81277170
126MP0003011_delayed_dark_adaptation0.80759076
127MP0003878_abnormal_ear_physiology0.80715747
128MP0005377_hearing/vestibular/ear_phenot0.80715747
129MP0000778_abnormal_nervous_system0.80631892
130MP0006138_congestive_heart_failure0.79031103
131MP0001486_abnormal_startle_reflex0.78474485
132MP0001800_abnormal_humoral_immune0.77896192
133MP0002009_preneoplasia0.77850846
134MP0004381_abnormal_hair_follicle0.77848714
135MP0002723_abnormal_immune_serum0.77787284
136MP0000639_abnormal_adrenal_gland0.77728204
137MP0002127_abnormal_cardiovascular_syste0.77676174
138MP0003252_abnormal_bile_duct0.77515268
139MP0010678_abnormal_skin_adnexa0.77162856
140MP0000013_abnormal_adipose_tissue0.76947425
141MP0005075_abnormal_melanosome_morpholog0.76409408
142MP0005620_abnormal_muscle_contractility0.75500707
143MP0002452_abnormal_antigen_presenting0.75231493
144MP0002752_abnormal_somatic_nervous0.74857972
145MP0005165_increased_susceptibility_to0.74425779
146MP0008057_abnormal_DNA_replication0.74079419
147MP0000371_diluted_coat_color0.73766765
148MP0005410_abnormal_fertilization0.72248600
149MP0003937_abnormal_limbs/digits/tail_de0.72239392
150MP0005595_abnormal_vascular_smooth0.72232659
151MP0001873_stomach_inflammation0.70306594
152MP0000343_altered_response_to0.69491466
153MP0005220_abnormal_exocrine_pancreas0.69251812
154MP0004142_abnormal_muscle_tone0.67886990
155MP0002163_abnormal_gland_morphology0.67872564
156MP0000470_abnormal_stomach_morphology0.67505526
157MP0005367_renal/urinary_system_phenotyp0.67367594
158MP0000516_abnormal_urinary_system0.67367594
159MP0001119_abnormal_female_reproductive0.67032936
160MP0001346_abnormal_lacrimal_gland0.66755687
161MP0001819_abnormal_immune_cell0.66314371
162MP0001963_abnormal_hearing_physiology0.66043315
163MP0003879_abnormal_hair_cell0.64430935
164MP0002420_abnormal_adaptive_immunity0.63935179
165MP0001270_distended_abdomen0.62347363
166MP0001845_abnormal_inflammatory_respons0.61921391
167MP0000490_abnormal_crypts_of0.61231802
168MP0002168_other_aberrant_phenotype0.59908022
169MP0002095_abnormal_skin_pigmentation0.59823795
170MP0005390_skeleton_phenotype0.58242677

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.02124593
2Hyperventilation (HP:0002883)4.30974045
3Pancreatic fibrosis (HP:0100732)4.22694878
4Abnormality of midbrain morphology (HP:0002418)4.09821666
5Molar tooth sign on MRI (HP:0002419)4.09821666
6Chromsome breakage (HP:0040012)4.00732937
7Genetic anticipation (HP:0003743)3.89777543
8Chronic hepatic failure (HP:0100626)3.75146307
9Nephronophthisis (HP:0000090)3.65288271
10Duplicated collecting system (HP:0000081)3.61562335
11Medial flaring of the eyebrow (HP:0010747)3.43018046
12Osteomalacia (HP:0002749)3.35522663
13Abnormality of the renal medulla (HP:0100957)3.34911393
14Abnormality of the renal collecting system (HP:0004742)3.30113005
15Progressive cerebellar ataxia (HP:0002073)3.24032978
16Prostate neoplasm (HP:0100787)3.23258493
17Abnormality of alanine metabolism (HP:0010916)3.10649052
18Hyperalaninemia (HP:0003348)3.10649052
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.10649052
20Gaze-evoked nystagmus (HP:0000640)3.10049936
21Renal cortical cysts (HP:0000803)3.08232836
22Febrile seizures (HP:0002373)3.07903532
23Congenital sensorineural hearing impairment (HP:0008527)3.06272557
24Alveolar cell carcinoma (HP:0006519)3.04793962
25Attenuation of retinal blood vessels (HP:0007843)3.00385443
26Cystic liver disease (HP:0006706)3.00089761
27Abolished electroretinogram (ERG) (HP:0000550)2.98232068
28Large for gestational age (HP:0001520)2.95418037
29Tubular atrophy (HP:0000092)2.85162234
30Hypothermia (HP:0002045)2.84515139
31Absent eyebrow (HP:0002223)2.80613442
32Neoplasm of the tracheobronchial system (HP:0100552)2.74655899
33Hypoplasia of the fovea (HP:0007750)2.74391260
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.74391260
35Hypergonadotropic hypogonadism (HP:0000815)2.74140195
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.74043995
37Absent/shortened dynein arms (HP:0200106)2.74043995
38Abnormal ciliary motility (HP:0012262)2.71955672
39Gait imbalance (HP:0002141)2.67772643
40True hermaphroditism (HP:0010459)2.67626657
41Pendular nystagmus (HP:0012043)2.66711752
42Congenital stationary night blindness (HP:0007642)2.65220335
43Genital tract atresia (HP:0001827)2.64322012
44Hyperphosphatemia (HP:0002905)2.59223495
45Inability to walk (HP:0002540)2.59110510
46Type II lissencephaly (HP:0007260)2.58111605
47Abnormal drinking behavior (HP:0030082)2.56774060
48Polydipsia (HP:0001959)2.56774060
49Congenital primary aphakia (HP:0007707)2.55842671
50Tachypnea (HP:0002789)2.52579373
51Stomach cancer (HP:0012126)2.50377101
52Bile duct proliferation (HP:0001408)2.46175606
53Abnormal biliary tract physiology (HP:0012439)2.46175606
54Abnormal respiratory motile cilium morphology (HP:0005938)2.45482901
55Abnormal respiratory epithelium morphology (HP:0012253)2.45482901
56Hemiparesis (HP:0001269)2.44891047
57Septo-optic dysplasia (HP:0100842)2.41369085
58Vaginal atresia (HP:0000148)2.41114395
59Abnormal rod and cone electroretinograms (HP:0008323)2.36515959
60Broad-based gait (HP:0002136)2.34795025
61Patchy hypopigmentation of hair (HP:0011365)2.34313804
62Abnormality of DNA repair (HP:0003254)2.32779896
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.32069625
64Nephrogenic diabetes insipidus (HP:0009806)2.31393173
65Tubulointerstitial nephritis (HP:0001970)2.30947020
66White forelock (HP:0002211)2.30424512
67Unilateral renal agenesis (HP:0000122)2.30400722
68Aplasia cutis congenita (HP:0001057)2.29357794
69Decreased central vision (HP:0007663)2.27865039
70Intestinal atresia (HP:0011100)2.27312567
71Furrowed tongue (HP:0000221)2.25914190
72Keratoconus (HP:0000563)2.25325965
73Increased corneal curvature (HP:0100692)2.25325965
74Focal seizures (HP:0007359)2.25273431
75Widely spaced teeth (HP:0000687)2.24082434
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.22210241
77Decreased circulating renin level (HP:0003351)2.21132628
78Abnormality of calcium-phosphate metabolism (HP:0100530)2.20254927
79Abnormality of the dental pulp (HP:0006479)2.19641349
80Retrobulbar optic neuritis (HP:0100654)2.18408744
81Optic neuritis (HP:0100653)2.18408744
82Clumsiness (HP:0002312)2.17689000
83Sclerocornea (HP:0000647)2.16963499
84Clubbing of toes (HP:0100760)2.16919526
85Abnormality of the fovea (HP:0000493)2.16910284
86Progressive inability to walk (HP:0002505)2.15815651
87Abnormality of the renal cortex (HP:0011035)2.15702431
88Chorioretinal atrophy (HP:0000533)2.15377890
89Abnormal respiratory motile cilium physiology (HP:0012261)2.14965272
90Ectopic kidney (HP:0000086)2.14401252
91Type I transferrin isoform profile (HP:0003642)2.14242852
92Conical tooth (HP:0000698)2.12031170
93Joint hemorrhage (HP:0005261)2.10728580
94Abnormality of incisor morphology (HP:0011063)2.10724521
95Submucous cleft hard palate (HP:0000176)2.10695039
96Thyroiditis (HP:0100646)2.10646672
97Cheilitis (HP:0100825)2.09827670
98Lip pit (HP:0100267)2.09724752
99Absent speech (HP:0001344)2.07971084
100Cerebellar dysplasia (HP:0007033)2.07274070
101Fair hair (HP:0002286)2.06425818
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05749044
103Symptomatic seizures (HP:0011145)2.05081935
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03649664
105Polyuria (HP:0000103)2.03410312
106Hypoplastic iliac wings (HP:0002866)2.02979804
107Abnormal hair whorl (HP:0010721)2.02122875
108Abnormality of B cell number (HP:0010975)2.01595419
109Median cleft lip (HP:0000161)2.01505172
110Optic nerve hypoplasia (HP:0000609)2.00448970
111Abnormality of molar (HP:0011077)1.98519266
112Abnormality of molar morphology (HP:0011070)1.98519266
113Abnormality of renal resorption (HP:0011038)1.98195517
114Recurrent abscess formation (HP:0002722)1.97769199
115Recurrent pneumonia (HP:0006532)1.97645731
116Tetany (HP:0001281)1.97512077
117Portal hypertension (HP:0001409)1.96221791
118Abnormality of the hepatic vasculature (HP:0006707)1.95191281
119Epileptic encephalopathy (HP:0200134)1.95041091
120Amelogenesis imperfecta (HP:0000705)1.95028680
121Poor coordination (HP:0002370)1.93152292
122Morphological abnormality of the middle ear (HP:0008609)1.90739705
123Tubulointerstitial fibrosis (HP:0005576)1.89292868
124Postaxial foot polydactyly (HP:0001830)1.89245169
125Abnormality of the pons (HP:0007361)1.89234148
126Ketoacidosis (HP:0001993)1.88880541
127Vascular calcification (HP:0004934)1.87923386
128Reduced antithrombin III activity (HP:0001976)1.87862668
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87613371
130Short foot (HP:0001773)1.87550940
131Hypoproteinemia (HP:0003075)1.86904922
132Orchitis (HP:0100796)1.86810138
133Generalized hypopigmentation of hair (HP:0011358)1.86460967
134Bulbous nose (HP:0000414)1.84583161
135Parakeratosis (HP:0001036)1.84161024
136Pulmonary artery stenosis (HP:0004415)1.83640218
137Protruding tongue (HP:0010808)1.83374906
138Congenital hepatic fibrosis (HP:0002612)1.82515151
139Severe visual impairment (HP:0001141)1.82152475
140Nonimmune hydrops fetalis (HP:0001790)1.82041163
141Pancreatic cysts (HP:0001737)1.81927468
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.80467108
143Distal lower limb muscle weakness (HP:0009053)1.80299787
144Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78901009
145Metaphyseal dysplasia (HP:0100255)1.77684123
146Lissencephaly (HP:0001339)1.77570167
147Hypoplastic ischia (HP:0003175)1.77537463
148Upper limb muscle weakness (HP:0003484)1.77449460
149Capillary hemangiomas (HP:0005306)1.76493035
150Ectropion (HP:0000656)1.76073160
151Tubulointerstitial abnormality (HP:0001969)1.75995123
152Postaxial hand polydactyly (HP:0001162)1.75452620
153Anencephaly (HP:0002323)1.75381798
154Palpebral edema (HP:0100540)1.74736365
155Abnormality of homocysteine metabolism (HP:0010919)1.74535807
156Homocystinuria (HP:0002156)1.74535807
157Abnormal delayed hypersensitivity skin test (HP:0002963)1.74406762
158B lymphocytopenia (HP:0010976)1.74383472
159Atonic seizures (HP:0010819)1.73956239
160Spontaneous hematomas (HP:0007420)1.73526347
161Male pseudohermaphroditism (HP:0000037)1.72451498
162Abnormality of the ischium (HP:0003174)1.72221137
163Hypoplasia of the iris (HP:0007676)1.72211991
164Drooling (HP:0002307)1.71785384
165Abnormality of the prostate (HP:0008775)1.71266348
166Conjugated hyperbilirubinemia (HP:0002908)1.70821453
167Gingivitis (HP:0000230)1.70617700
168Left ventricular hypertrophy (HP:0001712)1.70427163
169Adactyly (HP:0009776)1.70214556
170Severe muscular hypotonia (HP:0006829)1.70190427
171Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69945535
172Neoplasm of the lung (HP:0100526)1.69809247
173Ketosis (HP:0001946)1.69348391
174Abnormality of the pubic bones (HP:0003172)1.69135936
175Type 2 muscle fiber atrophy (HP:0003554)1.69082756
176Abnormality of the preputium (HP:0100587)1.69062322
177Bony spicule pigmentary retinopathy (HP:0007737)1.67898750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.65576753
2ZAK3.75182341
3KDR3.33600564
4IRAK33.16716407
5CASK2.80465694
6MAP3K142.68575231
7SIK32.31985028
8INSRR2.25614336
9MAP4K22.25188604
10AKT32.23187260
11TAOK32.22956827
12IRAK42.11982785
13TXK2.11021871
14GRK12.06317575
15WNK41.94137905
16BRSK21.91252948
17ACVR1B1.88873388
18EIF2AK21.87803493
19WNK31.84299302
20TGFBR21.80246545
21SGK21.78444872
22PRPF4B1.76366344
23STK161.74861732
24TNIK1.73219629
25STK391.57802251
26MAPK151.55841863
27BMPR21.52230665
28IKBKE1.49973637
29TEC1.48293294
30MAP3K41.43548056
31OXSR11.42502887
32PAK31.42219811
33ADRBK21.41914451
34YES11.40150460
35NEK61.33386405
36CAMKK21.28344611
37BRD41.26182875
38ADRBK11.17776754
39MAPK131.16814863
40MAP2K71.14724546
41GRK71.14249044
42SGK2231.12410653
43SGK4941.12410653
44FGFR21.12039273
45STK38L1.11855356
46MARK11.11554612
47PTK2B1.11445033
48ERBB31.07933825
49PLK41.07207824
50BMPR1B1.07135852
51SGK31.05846662
52CDK31.05400707
53CSNK1A1L1.02820861
54IKBKB1.02372426
55NUAK10.99439071
56TAOK20.98476146
57BCR0.96486033
58JAK10.95271715
59PBK0.94783892
60PIK3CG0.94386860
61CHUK0.89719473
62MAP3K70.89485325
63PRKCG0.88318432
64CDK80.87388139
65PINK10.87235826
66JAK30.84937487
67CLK10.84555096
68MUSK0.83282698
69TGFBR10.82712929
70NEK90.82544740
71CAMK10.82510579
72CSNK1G10.81144281
73EPHA40.81003047
74FER0.80713463
75BLK0.78011543
76PIK3CA0.76024098
77STK30.74837935
78EPHA20.74441936
79FRK0.74159111
80MAPK70.73503933
81EPHB20.72143589
82ITK0.71921574
83LATS10.71111255
84MKNK20.70551879
85OBSCN0.69783026
86EPHA30.69343607
87TNK20.66570606
88TRPM70.66017805
89IRAK10.65510223
90CSNK1G20.65477545
91BTK0.62813821
92PRKCE0.59016249
93CSNK1G30.58781216
94TRIM280.58382154
95BCKDK0.55747653
96STK380.55674308
97MAPKAPK30.53492876
98NLK0.53067529
99TLK10.52860305
100PRKAA10.52274883
101LYN0.52217000
102DAPK20.51287263
103MYLK0.51189958
104NTRK30.50777027
105SGK10.49856874
106DYRK1A0.49720099
107STK110.48658387
108GRK50.48011013
109CAMK40.47545272
110MST40.47296083
111MAPK110.46964364
112CDK120.46650734
113TYK20.46094000
114MAPK120.44482480
115IRAK20.44251757
116CAMK1D0.44212148
117WNK10.44116537
118PRKCI0.43882642
119LIMK10.43844154
120HCK0.43150102
121TBK10.42203071
122KIT0.42058545
123PKN10.41493953
124SIK20.40565927
125CAMK1G0.40182720
126PHKG20.39861114
127PHKG10.39861114
128CSNK1D0.39272246
129NME20.38851086
130NME10.38004380
131PLK20.37561881
132CDK90.37422173
133FLT30.37049441
134MAP2K10.37006172
135IGF1R0.36716135
136SRPK10.36306915
137PIM10.34194753
138ERBB20.33921677
139ABL10.33178704
140PRKCQ0.32577687
141SYK0.32384247
142STK240.31831691
143RPS6KB10.28421536
144PRKCH0.28238773
145CSK0.27878891
146PRKACA0.27756768
147VRK10.27411005
148BRAF0.27319825
149PRKAA20.27295305
150CAMK2A0.26799716
151MKNK10.25722840
152PRKG10.25718235
153AKT10.25026707
154MAP2K20.24954908
155PRKCD0.24839520

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.49318559
2Butanoate metabolism_Homo sapiens_hsa006502.47111521
3Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.27923944
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.17556968
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10437788
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07692163
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06562194
8Autoimmune thyroid disease_Homo sapiens_hsa053202.00286959
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.99922396
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94802325
11Fanconi anemia pathway_Homo sapiens_hsa034601.91594968
12Malaria_Homo sapiens_hsa051441.86340477
13Selenocompound metabolism_Homo sapiens_hsa004501.86058186
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81356967
15Arachidonic acid metabolism_Homo sapiens_hsa005901.79268304
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78851061
17Tryptophan metabolism_Homo sapiens_hsa003801.78131515
18Phototransduction_Homo sapiens_hsa047441.75250249
19Vitamin digestion and absorption_Homo sapiens_hsa049771.71624045
20Rheumatoid arthritis_Homo sapiens_hsa053231.67875895
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66857192
22Sphingolipid metabolism_Homo sapiens_hsa006001.63376525
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.62325576
24Other glycan degradation_Homo sapiens_hsa005111.61981374
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61701729
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.61272066
27Taste transduction_Homo sapiens_hsa047421.60939020
28African trypanosomiasis_Homo sapiens_hsa051431.53615693
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53300693
30Circadian rhythm_Homo sapiens_hsa047101.52760754
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51909430
32Allograft rejection_Homo sapiens_hsa053301.50585049
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49723320
34Hematopoietic cell lineage_Homo sapiens_hsa046401.48581648
35Nicotine addiction_Homo sapiens_hsa050331.46671098
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46229082
37ABC transporters_Homo sapiens_hsa020101.42946834
38Measles_Homo sapiens_hsa051621.41235251
39Staphylococcus aureus infection_Homo sapiens_hsa051501.40628961
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33498137
41Pancreatic secretion_Homo sapiens_hsa049721.31421842
42Dorso-ventral axis formation_Homo sapiens_hsa043201.31238130
43Ovarian steroidogenesis_Homo sapiens_hsa049131.30561940
44Caffeine metabolism_Homo sapiens_hsa002321.30493617
45Regulation of autophagy_Homo sapiens_hsa041401.29687025
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25215198
47Morphine addiction_Homo sapiens_hsa050321.25169939
48Propanoate metabolism_Homo sapiens_hsa006401.23493237
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20707924
50Graft-versus-host disease_Homo sapiens_hsa053321.20389324
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16425525
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14976413
53Chemical carcinogenesis_Homo sapiens_hsa052041.10805123
54Primary immunodeficiency_Homo sapiens_hsa053401.07178649
55Asthma_Homo sapiens_hsa053101.05813398
56Histidine metabolism_Homo sapiens_hsa003401.05612639
57Homologous recombination_Homo sapiens_hsa034401.05611069
58Renin secretion_Homo sapiens_hsa049241.05099291
59Glycerolipid metabolism_Homo sapiens_hsa005611.04281406
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.04031970
61Linoleic acid metabolism_Homo sapiens_hsa005911.03707106
62Influenza A_Homo sapiens_hsa051641.01024086
63Protein digestion and absorption_Homo sapiens_hsa049740.99013120
64Leishmaniasis_Homo sapiens_hsa051400.98850850
65Herpes simplex infection_Homo sapiens_hsa051680.98110678
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96515640
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.95371203
68TNF signaling pathway_Homo sapiens_hsa046680.94139530
69Non-homologous end-joining_Homo sapiens_hsa034500.92045496
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.90930309
71Collecting duct acid secretion_Homo sapiens_hsa049660.90843367
72Oxytocin signaling pathway_Homo sapiens_hsa049210.90247021
73Pertussis_Homo sapiens_hsa051330.88816388
74Lysine degradation_Homo sapiens_hsa003100.88397281
75Insulin secretion_Homo sapiens_hsa049110.86683860
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84849018
77Peroxisome_Homo sapiens_hsa041460.83154857
78Calcium signaling pathway_Homo sapiens_hsa040200.82661126
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82080645
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81866633
81Serotonergic synapse_Homo sapiens_hsa047260.81542587
82Phagosome_Homo sapiens_hsa041450.79865810
83Type I diabetes mellitus_Homo sapiens_hsa049400.79013893
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.77598197
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.74825206
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73380301
87Legionellosis_Homo sapiens_hsa051340.73171082
88Protein export_Homo sapiens_hsa030600.72566891
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72301622
90Long-term depression_Homo sapiens_hsa047300.70760220
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69588801
92Osteoclast differentiation_Homo sapiens_hsa043800.68912396
93Ether lipid metabolism_Homo sapiens_hsa005650.67905454
94Gastric acid secretion_Homo sapiens_hsa049710.66422922
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64989701
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64369900
97Fat digestion and absorption_Homo sapiens_hsa049750.64013726
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62687138
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62202450
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62185854
101Dopaminergic synapse_Homo sapiens_hsa047280.62154750
102Cholinergic synapse_Homo sapiens_hsa047250.62152012
103Fatty acid degradation_Homo sapiens_hsa000710.61644461
104RNA degradation_Homo sapiens_hsa030180.61607175
105Chemokine signaling pathway_Homo sapiens_hsa040620.61561375
106Tuberculosis_Homo sapiens_hsa051520.61479694
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61421160
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60791025
109Lysosome_Homo sapiens_hsa041420.60609659
110Olfactory transduction_Homo sapiens_hsa047400.60493959
111Fatty acid biosynthesis_Homo sapiens_hsa000610.60150827
112Circadian entrainment_Homo sapiens_hsa047130.59598910
113Amphetamine addiction_Homo sapiens_hsa050310.59421850
114beta-Alanine metabolism_Homo sapiens_hsa004100.57459797
115Hepatitis C_Homo sapiens_hsa051600.55856337
116Retinol metabolism_Homo sapiens_hsa008300.53965075
117One carbon pool by folate_Homo sapiens_hsa006700.52612002
118Complement and coagulation cascades_Homo sapiens_hsa046100.52502502
119cAMP signaling pathway_Homo sapiens_hsa040240.52038858
120Sulfur metabolism_Homo sapiens_hsa009200.50777149
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49569099
122Phenylalanine metabolism_Homo sapiens_hsa003600.49280421
123Purine metabolism_Homo sapiens_hsa002300.49170406
124Mineral absorption_Homo sapiens_hsa049780.48034252
125Steroid biosynthesis_Homo sapiens_hsa001000.47795831
126Apoptosis_Homo sapiens_hsa042100.47565112
127RNA polymerase_Homo sapiens_hsa030200.47470637
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47326609
129Cardiac muscle contraction_Homo sapiens_hsa042600.46883003
130Dilated cardiomyopathy_Homo sapiens_hsa054140.46176130
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46012960
132Cocaine addiction_Homo sapiens_hsa050300.44742991
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44210647
134ECM-receptor interaction_Homo sapiens_hsa045120.43297422
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43256402
136Ras signaling pathway_Homo sapiens_hsa040140.41926864
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.41674482
138Basal transcription factors_Homo sapiens_hsa030220.41447839
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40815778
140Fatty acid metabolism_Homo sapiens_hsa012120.40639058
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40623125
142Glutamatergic synapse_Homo sapiens_hsa047240.40442778
143Toxoplasmosis_Homo sapiens_hsa051450.39476088
144GABAergic synapse_Homo sapiens_hsa047270.37259792
145Platelet activation_Homo sapiens_hsa046110.35773801
146Prolactin signaling pathway_Homo sapiens_hsa049170.34520852
147Salivary secretion_Homo sapiens_hsa049700.34416659
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34318309
149Type II diabetes mellitus_Homo sapiens_hsa049300.32964654

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