SYT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79613911
2vocalization behavior (GO:0071625)5.46480581
3synaptic vesicle exocytosis (GO:0016079)5.45773903
4pyrimidine nucleobase catabolic process (GO:0006208)5.44111380
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.38374224
6synaptic vesicle maturation (GO:0016188)5.37241058
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24347196
8locomotory exploration behavior (GO:0035641)5.23647182
9neuronal action potential propagation (GO:0019227)5.12908110
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11554709
11glutamate secretion (GO:0014047)4.89865549
12protein localization to synapse (GO:0035418)4.84197029
13neuron cell-cell adhesion (GO:0007158)4.80467911
14regulation of synaptic vesicle exocytosis (GO:2000300)4.75490373
15regulation of glutamate receptor signaling pathway (GO:1900449)4.72017883
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.70982477
17neurotransmitter secretion (GO:0007269)4.59172691
18exploration behavior (GO:0035640)4.49216296
19nucleobase catabolic process (GO:0046113)4.47390704
20establishment of mitochondrion localization (GO:0051654)4.41363359
21glutamate receptor signaling pathway (GO:0007215)4.31568898
22regulation of synaptic vesicle transport (GO:1902803)4.21853922
23cell migration in hindbrain (GO:0021535)4.21080358
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17981900
25synaptic transmission, glutamatergic (GO:0035249)4.17194432
26regulation of neuronal synaptic plasticity (GO:0048168)4.16236212
27neuron-neuron synaptic transmission (GO:0007270)4.08425172
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04025536
29layer formation in cerebral cortex (GO:0021819)4.02301858
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.01033493
31gamma-aminobutyric acid transport (GO:0015812)3.97817107
32response to dietary excess (GO:0002021)3.96132289
33dendritic spine morphogenesis (GO:0060997)3.90458248
34cerebellar granule cell differentiation (GO:0021707)3.85448925
35neurofilament cytoskeleton organization (GO:0060052)3.82747111
36long-term memory (GO:0007616)3.82383125
37neuron recognition (GO:0008038)3.81671726
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76314476
39neurotransmitter transport (GO:0006836)3.76280335
40cellular potassium ion homeostasis (GO:0030007)3.76266203
41neuromuscular process controlling posture (GO:0050884)3.74561598
42regulation of synapse structural plasticity (GO:0051823)3.73024435
43neurotransmitter-gated ion channel clustering (GO:0072578)3.71191632
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70581740
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.69024759
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69008490
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66281006
48positive regulation of membrane potential (GO:0045838)3.62507196
49establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.62404364
50mitochondrion transport along microtubule (GO:0047497)3.62404364
51proline transport (GO:0015824)3.62321456
52transmission of nerve impulse (GO:0019226)3.61227570
53regulation of postsynaptic membrane potential (GO:0060078)3.59841647
54regulation of neurotransmitter levels (GO:0001505)3.53171581
55regulation of voltage-gated calcium channel activity (GO:1901385)3.50716064
56potassium ion homeostasis (GO:0055075)3.49857544
57regulation of dendritic spine morphogenesis (GO:0061001)3.44202372
58regulation of synapse maturation (GO:0090128)3.44007937
59axonal fasciculation (GO:0007413)3.43432476
60positive regulation of synapse assembly (GO:0051965)3.42533327
61positive regulation of synapse maturation (GO:0090129)3.40959408
62synaptic vesicle endocytosis (GO:0048488)3.37549862
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37226334
64regulation of synaptic plasticity (GO:0048167)3.36002230
65activation of protein kinase A activity (GO:0034199)3.35995880
66postsynaptic membrane organization (GO:0001941)3.32342468
67dendritic spine organization (GO:0097061)3.32294055
68cerebellar Purkinje cell differentiation (GO:0021702)3.32001280
69sodium ion export (GO:0071436)3.30381461
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29197343
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28552510
72adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.28339064
73long-term synaptic potentiation (GO:0060291)3.27487816
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26610781
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25471013
76neuromuscular synaptic transmission (GO:0007274)3.23790475
77regulation of neurotransmitter secretion (GO:0046928)3.22356128
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.20566831
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19287166
80neuromuscular process controlling balance (GO:0050885)3.18704996
81response to histamine (GO:0034776)3.18424144
82membrane hyperpolarization (GO:0060081)3.15367574
83presynaptic membrane assembly (GO:0097105)3.14705841
84behavioral response to cocaine (GO:0048148)3.14265221
85membrane depolarization (GO:0051899)3.13338652
86* regulation of vesicle fusion (GO:0031338)3.12803808
87synaptic vesicle transport (GO:0048489)3.12142664
88establishment of synaptic vesicle localization (GO:0097480)3.12142664
89cell communication by electrical coupling (GO:0010644)3.11946986
90positive regulation of dendritic spine development (GO:0060999)3.11856408
91membrane depolarization during action potential (GO:0086010)3.11025327
92neuronal ion channel clustering (GO:0045161)3.02926042
93glycine transport (GO:0015816)3.02483095
94synapse assembly (GO:0007416)3.01817245
95positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01692898
96innervation (GO:0060384)3.01420784
97amino acid import (GO:0043090)3.01017629
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00948861
99positive regulation of neurotransmitter transport (GO:0051590)3.00772286
100mating behavior (GO:0007617)3.00662311
101synaptic transmission (GO:0007268)3.00395963
102learning (GO:0007612)3.00385834
103response to auditory stimulus (GO:0010996)2.99969513
104auditory behavior (GO:0031223)2.99847746
105regulation of dendritic spine development (GO:0060998)2.99809580
106regulation of neurotransmitter transport (GO:0051588)2.99664706
107presynaptic membrane organization (GO:0097090)2.99268242
108axon cargo transport (GO:0008088)2.98484258
109positive regulation of neurotransmitter secretion (GO:0001956)2.98465210
110prepulse inhibition (GO:0060134)2.97773526
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96087051
112regulation of glutamate secretion (GO:0014048)2.96020140
113behavioral defense response (GO:0002209)2.94711536
114behavioral fear response (GO:0001662)2.94711536
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93747985
116positive regulation of dendritic spine morphogenesis (GO:0061003)2.92210841
117adult walking behavior (GO:0007628)2.91366490
118dendrite morphogenesis (GO:0048813)2.90304261
119startle response (GO:0001964)2.89259348
120social behavior (GO:0035176)2.89138228
121intraspecies interaction between organisms (GO:0051703)2.89138228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40847408
2GBX2_23144817_ChIP-Seq_PC3_Human3.56543986
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21128461
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18736498
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15944304
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.81683999
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76450760
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75910541
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75910541
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66507342
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60724662
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59252498
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57723534
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57029071
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.55903459
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.44042654
17DROSHA_22980978_ChIP-Seq_HELA_Human2.37309664
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34400523
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.33528924
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.32319890
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.27796878
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19896030
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.16545901
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14105102
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06973700
26TAF15_26573619_Chip-Seq_HEK293_Human2.06767821
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91408768
28AR_21572438_ChIP-Seq_LNCaP_Human1.85127667
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83798144
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79980389
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78190203
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.73872632
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72349454
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.69176365
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68314784
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62296765
37SMAD4_21799915_ChIP-Seq_A2780_Human1.60516495
38ZNF274_21170338_ChIP-Seq_K562_Hela1.50578020
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47563180
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45663088
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43027425
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41385142
43P300_19829295_ChIP-Seq_ESCs_Human1.39980585
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39524174
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38930047
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38578286
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35162520
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.34586816
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33957933
50FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31697170
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.31565635
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30093196
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28878805
54* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27604741
55IGF1R_20145208_ChIP-Seq_DFB_Human1.27333288
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.25416615
57* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25006094
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.24976083
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24936637
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24040547
61AR_25329375_ChIP-Seq_VCAP_Human1.22006380
62OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19226276
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.16776978
64AR_19668381_ChIP-Seq_PC3_Human1.15132078
65STAT3_23295773_ChIP-Seq_U87_Human1.14876554
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14732492
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14591323
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13948698
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12285736
70RNF2_27304074_Chip-Seq_NSC_Mouse1.12169667
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09772149
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07447881
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.05227998
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03819083
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.01710513
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01483124
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01455821
78TCF4_23295773_ChIP-Seq_U87_Human0.99822502
79VDR_22108803_ChIP-Seq_LS180_Human0.98825878
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98248238
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98063620
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97334067
83RUNX2_22187159_ChIP-Seq_PCA_Human0.96441959
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96183305
85YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94724480
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94029912
87ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93414822
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.93215988
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.93105192
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.92330030
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91980888
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91388307
93* KDM2B_26808549_Chip-Seq_K562_Human0.90770282
94FUS_26573619_Chip-Seq_HEK293_Human0.90746800
95BCAT_22108803_ChIP-Seq_LS180_Human0.90730530
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90458472
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.89988365
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89635319
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88933290
100JUN_21703547_ChIP-Seq_K562_Human0.88387844
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88213056
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87658989
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.86314105
104CTCF_27219007_Chip-Seq_Bcells_Human0.86283210
105* OCT4_19829295_ChIP-Seq_ESCs_Human0.86278358
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86128088
107AHR_22903824_ChIP-Seq_MCF-7_Human0.85866273
108* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84006854
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83758518
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83284955
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83284955
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.82308299
113NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79963216
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79811619
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77451648
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75768297
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.74392442
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73312727
119ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73115804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.98981953
2MP0003880_abnormal_central_pattern5.15987098
3MP0003635_abnormal_synaptic_transmissio4.11557555
4MP0004270_analgesia3.54903253
5MP0009745_abnormal_behavioral_response3.41482405
6MP0009046_muscle_twitch3.23237754
7MP0002063_abnormal_learning/memory/cond3.21721360
8MP0002064_seizures3.16508083
9MP0001968_abnormal_touch/_nociception2.99286959
10MP0005423_abnormal_somatic_nervous2.79866045
11MP0002572_abnormal_emotion/affect_behav2.76615216
12MP0002272_abnormal_nervous_system2.75372570
13MP0002822_catalepsy2.67704106
14MP0001486_abnormal_startle_reflex2.64075757
15MP0002734_abnormal_mechanical_nocicepti2.63650234
16MP0002736_abnormal_nociception_after2.45123400
17MP0001501_abnormal_sleep_pattern2.37290862
18MP0002735_abnormal_chemical_nociception2.31589229
19MP0001440_abnormal_grooming_behavior2.25790137
20MP0006276_abnormal_autonomic_nervous2.19685130
21MP0002733_abnormal_thermal_nociception2.11982494
22MP0002067_abnormal_sensory_capabilities2.03977143
23MP0001970_abnormal_pain_threshold2.02398871
24MP0003329_amyloid_beta_deposits1.97909485
25MP0002184_abnormal_innervation1.96260310
26MP0009780_abnormal_chondrocyte_physiolo1.89517473
27MP0008569_lethality_at_weaning1.85233798
28MP0004924_abnormal_behavior1.79792696
29MP0005386_behavior/neurological_phenoty1.79792696
30MP0002557_abnormal_social/conspecific_i1.79722506
31MP0004142_abnormal_muscle_tone1.72064663
32MP0000778_abnormal_nervous_system1.71931767
33MP0002909_abnormal_adrenal_gland1.71129114
34MP0001529_abnormal_vocalization1.68540883
35MP0000955_abnormal_spinal_cord1.64177776
36MP0004811_abnormal_neuron_physiology1.63666153
37MP0001984_abnormal_olfaction1.60176319
38MP0004858_abnormal_nervous_system1.57677072
39MP0003123_paternal_imprinting1.54535652
40MP0003121_genomic_imprinting1.46712497
41MP0003879_abnormal_hair_cell1.45360422
42MP0002066_abnormal_motor_capabilities/c1.44682432
43MP0002882_abnormal_neuron_morphology1.42789078
44MP0005646_abnormal_pituitary_gland1.42672332
45MP0001905_abnormal_dopamine_level1.33492077
46MP0005645_abnormal_hypothalamus_physiol1.32676410
47MP0001502_abnormal_circadian_rhythm1.29828364
48MP0004147_increased_porphyrin_level1.29076364
49MP0003122_maternal_imprinting1.28624907
50MP0003787_abnormal_imprinting1.28094028
51MP0004885_abnormal_endolymph1.28084262
52MP0008877_abnormal_DNA_methylation1.24811517
53MP0003633_abnormal_nervous_system1.21687979
54MP0001188_hyperpigmentation1.20144114
55MP0004145_abnormal_muscle_electrophysio1.13425147
56MP0002837_dystrophic_cardiac_calcinosis1.13201606
57MP0002229_neurodegeneration1.10898860
58MP0003631_nervous_system_phenotype1.07356952
59MP0002152_abnormal_brain_morphology1.05276236
60MP0000751_myopathy1.05150630
61MP0010386_abnormal_urinary_bladder1.04208422
62MP0001986_abnormal_taste_sensitivity1.03570448
63MP0008872_abnormal_physiological_respon1.02850562
64MP0005535_abnormal_body_temperature1.01650023
65MP0005187_abnormal_penis_morphology1.00968316
66MP0005551_abnormal_eye_electrophysiolog1.00164610
67MP0002069_abnormal_eating/drinking_beha0.95854988
68MP0004742_abnormal_vestibular_system0.95459452
69MP0005409_darkened_coat_color0.91480771
70MP0000604_amyloidosis0.90917409
71MP0008874_decreased_physiological_sensi0.89554995
72MP0004085_abnormal_heartbeat0.87403902
73MP0000013_abnormal_adipose_tissue0.86497694
74MP0001963_abnormal_hearing_physiology0.86221777
75MP0005394_taste/olfaction_phenotype0.86140637
76MP0005499_abnormal_olfactory_system0.86140637
77MP0003634_abnormal_glial_cell0.85354932
78MP0002752_abnormal_somatic_nervous0.83925272
79MP0003690_abnormal_glial_cell0.83206851
80MP0003632_abnormal_nervous_system0.82860899
81MP0002638_abnormal_pupillary_reflex0.82653494
82MP0004133_heterotaxia0.81904270
83MP0003283_abnormal_digestive_organ0.80706481
84MP0001664_abnormal_digestion0.78938958
85MP0000920_abnormal_myelination0.78140591
86MP0002090_abnormal_vision0.71974839
87MP0001485_abnormal_pinna_reflex0.71161581
88MP0003137_abnormal_impulse_conducting0.70182860
89MP0000631_abnormal_neuroendocrine_gland0.68883497
90MP0001177_atelectasis0.68080305
91MP0005623_abnormal_meninges_morphology0.67887042
92MP0002876_abnormal_thyroid_physiology0.64619644
93MP0003075_altered_response_to0.63793117
94MP0004215_abnormal_myocardial_fiber0.63649036
95MP0008961_abnormal_basal_metabolism0.59576803
96MP0002653_abnormal_ependyma_morphology0.59079455
97MP0003119_abnormal_digestive_system0.58808546
98MP0004484_altered_response_of0.58721668
99MP0006072_abnormal_retinal_apoptosis0.58199529
100MP0001299_abnormal_eye_distance/0.57255016
101MP0003938_abnormal_ear_development0.56956976
102MP0002102_abnormal_ear_morphology0.56695682
103MP0004233_abnormal_muscle_weight0.56021214
104MP0000026_abnormal_inner_ear0.55578417
105MP0004043_abnormal_pH_regulation0.55385826
106MP0001346_abnormal_lacrimal_gland0.54489368
107MP0001943_abnormal_respiration0.53327609
108MP0003878_abnormal_ear_physiology0.53142415
109MP0005377_hearing/vestibular/ear_phenot0.53142415
110MP0000579_abnormal_nail_morphology0.52225861
111MP0003956_abnormal_body_size0.51063033
112MP0010769_abnormal_survival0.50004276
113MP0000747_muscle_weakness0.49431240
114MP0003861_abnormal_nervous_system0.49261099
115MP0002082_postnatal_lethality0.48916182
116MP0010770_preweaning_lethality0.48916182
117MP0010768_mortality/aging0.46776691

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.68271210
2Myokymia (HP:0002411)6.84856254
3Focal seizures (HP:0007359)5.90113205
4Visual hallucinations (HP:0002367)5.46114429
5Atonic seizures (HP:0010819)5.14955056
6Epileptic encephalopathy (HP:0200134)4.83700131
7Febrile seizures (HP:0002373)4.65022423
8Absence seizures (HP:0002121)4.47730454
9Progressive cerebellar ataxia (HP:0002073)4.33643111
10Dialeptic seizures (HP:0011146)4.07548958
11Supranuclear gaze palsy (HP:0000605)4.06899859
12Generalized tonic-clonic seizures (HP:0002069)4.05045150
13Action tremor (HP:0002345)3.85393486
14Hyperventilation (HP:0002883)3.45750865
15Broad-based gait (HP:0002136)3.36917764
16Anxiety (HP:0000739)3.21137429
17Dysdiadochokinesis (HP:0002075)3.20403974
18Cerebral hypomyelination (HP:0006808)3.18396933
19Amblyopia (HP:0000646)3.09656308
20Gaze-evoked nystagmus (HP:0000640)3.09353528
21Depression (HP:0000716)3.09228576
22Neurofibrillary tangles (HP:0002185)3.09161369
23Poor eye contact (HP:0000817)3.08934255
24Dysmetria (HP:0001310)3.07794972
25Ankle clonus (HP:0011448)3.07606164
26Cerebral inclusion bodies (HP:0100314)3.05814899
27Truncal ataxia (HP:0002078)3.02747209
28Impaired vibration sensation in the lower limbs (HP:0002166)2.99715089
29Abnormal eating behavior (HP:0100738)2.99312414
30Hemiparesis (HP:0001269)2.91431414
31Mutism (HP:0002300)2.89505797
32Impaired social interactions (HP:0000735)2.88160499
33Abnormal social behavior (HP:0012433)2.88160499
34Status epilepticus (HP:0002133)2.79082842
35Scanning speech (HP:0002168)2.77822250
36Urinary bladder sphincter dysfunction (HP:0002839)2.77323805
37Epileptiform EEG discharges (HP:0011182)2.67261515
38Progressive inability to walk (HP:0002505)2.64833549
39Drooling (HP:0002307)2.62985830
40Excessive salivation (HP:0003781)2.62985830
41Spastic gait (HP:0002064)2.62273513
42Postural instability (HP:0002172)2.59510486
43EEG with generalized epileptiform discharges (HP:0011198)2.58596201
44Limb dystonia (HP:0002451)2.55604107
45Impaired smooth pursuit (HP:0007772)2.52823140
46Torticollis (HP:0000473)2.50381845
47Pheochromocytoma (HP:0002666)2.48724023
48Urinary urgency (HP:0000012)2.46468948
49Polyphagia (HP:0002591)2.46065092
50Peripheral hypomyelination (HP:0007182)2.45274788
51Diplopia (HP:0000651)2.43745121
52Abnormality of binocular vision (HP:0011514)2.43745121
53Hypsarrhythmia (HP:0002521)2.43675728
54Intention tremor (HP:0002080)2.42703832
55Focal dystonia (HP:0004373)2.40693662
56Generalized myoclonic seizures (HP:0002123)2.39634640
57Ulnar claw (HP:0001178)2.39431844
58Hemiplegia (HP:0002301)2.38635720
59Bradykinesia (HP:0002067)2.38129275
60Abnormality of the lower motor neuron (HP:0002366)2.38017376
61Abnormality of the corticospinal tract (HP:0002492)2.35870013
62Megalencephaly (HP:0001355)2.34577948
63Sleep apnea (HP:0010535)2.33694218
64Split foot (HP:0001839)2.32358227
65Insidious onset (HP:0003587)2.32212921
66Termporal pattern (HP:0011008)2.32212921
67Abnormality of the labia minora (HP:0012880)2.30882739
68Genetic anticipation (HP:0003743)2.29315294
69Ventricular fibrillation (HP:0001663)2.28649580
70CNS hypomyelination (HP:0003429)2.27317088
71Agitation (HP:0000713)2.25002578
72Degeneration of the lateral corticospinal tracts (HP:0002314)2.20901252
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20901252
74Absent speech (HP:0001344)2.20350985
75Spastic tetraplegia (HP:0002510)2.19608658
76Papilledema (HP:0001085)2.17731027
77Craniofacial dystonia (HP:0012179)2.17348922
78Delusions (HP:0000746)2.17199382
79Abnormality of ocular smooth pursuit (HP:0000617)2.16499424
80Stereotypic behavior (HP:0000733)2.14675957
81Neuroendocrine neoplasm (HP:0100634)2.14406001
82Psychosis (HP:0000709)2.12670636
83Inability to walk (HP:0002540)2.12449817
84Hypoplasia of the brainstem (HP:0002365)2.06611425
85Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06611425
86Lissencephaly (HP:0001339)2.05981205
87Lower limb muscle weakness (HP:0007340)2.04869974
88Fetal akinesia sequence (HP:0001989)2.04565407
89Impaired vibratory sensation (HP:0002495)1.97678730
90Neuronal loss in central nervous system (HP:0002529)1.96917960
91Apathy (HP:0000741)1.94134991
92Gait ataxia (HP:0002066)1.93302569
93Amyotrophic lateral sclerosis (HP:0007354)1.91673628
94Failure to thrive in infancy (HP:0001531)1.88286311
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88097558
96Incomplete penetrance (HP:0003829)1.87319168
97Cortical dysplasia (HP:0002539)1.85612128
98Dysmetric saccades (HP:0000641)1.83586229
99Pachygyria (HP:0001302)1.82239430
100Rapidly progressive (HP:0003678)1.82175492
101Hypoventilation (HP:0002791)1.81400607
102Hypoplasia of the corpus callosum (HP:0002079)1.79250121
103Retinal dysplasia (HP:0007973)1.78381448
104Esotropia (HP:0000565)1.78062448
105Morphological abnormality of the pyramidal tract (HP:0002062)1.77164401
106Abnormality of salivation (HP:0100755)1.76524375
107Rigidity (HP:0002063)1.75882164
108Insomnia (HP:0100785)1.74725294
109Clonus (HP:0002169)1.74569286
110Akinesia (HP:0002304)1.73886153
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73487613
112Lower limb asymmetry (HP:0100559)1.73134585
113Blue irides (HP:0000635)1.73020523
114Restlessness (HP:0000711)1.72339628
115Muscular hypotonia of the trunk (HP:0008936)1.71897823
116Gait imbalance (HP:0002141)1.71740458
117Unsteady gait (HP:0002317)1.71508117
118Specific learning disability (HP:0001328)1.71383317
119Abnormality of saccadic eye movements (HP:0000570)1.71288237
120Poor suck (HP:0002033)1.70389564
121Diminished motivation (HP:0000745)1.69679345
122Abnormal EKG (HP:0003115)1.69629304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.62150220
2EPHA44.26627795
3MAP3K93.73236206
4MAP3K43.16690074
5MARK13.15809217
6MINK12.98693962
7MAP2K72.61153434
8MAP3K122.52759125
9DYRK22.22618099
10DAPK22.12580447
11NTRK22.11801687
12PAK62.10994540
13MAP2K42.10723332
14CASK2.04849341
15RIPK41.97855799
16NTRK11.79974189
17KSR21.79444005
18TNIK1.68239570
19PNCK1.65000360
20GRK51.55870096
21PRKD31.55119178
22CAMKK11.54731603
23SIK21.54654657
24CDK51.50586867
25MAPK131.43417670
26KSR11.42317512
27DAPK11.39774004
28ARAF1.39575433
29CDK191.38748327
30STK381.34505755
31PLK21.30044722
32PRKCG1.27997428
33AKT31.26915524
34FES1.25868751
35CSNK1G31.24913279
36PHKG11.24543352
37PHKG21.24543352
38BRAF1.19089247
39UHMK11.16376972
40CAMK2A1.12139977
41CSNK1A1L1.11196948
42PRPF4B1.06931377
43CAMKK21.01747304
44CAMK2B0.96492415
45NME10.96160652
46OXSR10.93119705
47LMTK20.90324907
48CSNK1G10.90320073
49MAP3K20.89827202
50TRIM280.89644437
51PAK30.87316601
52CAMK1D0.85705990
53CDK180.85632509
54LATS20.85242391
55MAP3K130.85062782
56BMPR20.84485453
57CDK150.84152461
58CDK140.83836246
59STK110.83132049
60CSNK1G20.82959452
61MAP4K20.80934663
62DYRK1A0.79626767
63PINK10.78251578
64SGK2230.77922907
65SGK4940.77922907
66TYRO30.77705096
67CAMK10.77148653
68CAMK40.76830771
69RAF10.73237742
70CDK11A0.73175382
71PRKCH0.71035910
72PTK2B0.70074312
73WNK10.68000587
74BRSK10.67568498
75MARK20.67001922
76RET0.65716983
77CAMK2G0.65573700
78TAOK10.61566504
79TNK20.61330740
80CAMK2D0.61203585
81CSNK1E0.60877836
82PRKCE0.60097822
83LIMK10.59901236
84FGR0.59631094
85SGK10.57766283
86FER0.57644586
87MAP3K110.57120308
88GRK70.55852420
89PDPK10.55848401
90CDC42BPA0.54398446
91SGK20.53688292
92WNK30.53170317
93MUSK0.52494982
94MAP3K10.52118431
95PDK10.52091102
96PRKCZ0.50612071
97TESK10.50422063
98STK390.48943095
99ROCK20.47101697
100RPS6KA20.44537152
101NEK60.44477349
102MAP2K10.44449739
103WNK40.43976059
104RPS6KA30.43880293
105MAP3K60.43437258
106SCYL20.42943673
107DYRK1B0.42782877
108PRKG10.41527915
109FYN0.40895704
110BCR0.40844247
111MAPK100.40763996
112MAPK120.40745496
113SGK30.40555364
114CSNK1A10.40102857
115ALK0.38400486
116CAMK1G0.37022811
117PRKACA0.36362405
118CSNK1D0.35757547
119SIK30.35028505
120DAPK30.34978755
121PKN10.34584522
122PRKCA0.32741840
123PRKCB0.29332063
124AURKA0.29318364
125GSK3B0.28460735
126MAPK80.27006003
127PRKCI0.26851426

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08276767
2Synaptic vesicle cycle_Homo sapiens_hsa047213.40518792
3GABAergic synapse_Homo sapiens_hsa047272.77976610
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75991385
5Long-term potentiation_Homo sapiens_hsa047202.59756037
6Circadian entrainment_Homo sapiens_hsa047132.59619418
7Glutamatergic synapse_Homo sapiens_hsa047242.54614152
8Olfactory transduction_Homo sapiens_hsa047402.52193629
9Morphine addiction_Homo sapiens_hsa050322.49331718
10Amphetamine addiction_Homo sapiens_hsa050312.48440128
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32015519
12Dopaminergic synapse_Homo sapiens_hsa047282.16919403
13Salivary secretion_Homo sapiens_hsa049702.14530870
14Insulin secretion_Homo sapiens_hsa049112.09952452
15Taste transduction_Homo sapiens_hsa047421.99620687
16Cholinergic synapse_Homo sapiens_hsa047251.90534720
17Gastric acid secretion_Homo sapiens_hsa049711.83987116
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76722530
19Serotonergic synapse_Homo sapiens_hsa047261.74455287
20Cocaine addiction_Homo sapiens_hsa050301.74176567
21Collecting duct acid secretion_Homo sapiens_hsa049661.72550721
22Renin secretion_Homo sapiens_hsa049241.67997560
23Long-term depression_Homo sapiens_hsa047301.66713508
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65519147
25Calcium signaling pathway_Homo sapiens_hsa040201.60486120
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58981822
27Oxytocin signaling pathway_Homo sapiens_hsa049211.52801783
28Cardiac muscle contraction_Homo sapiens_hsa042601.37812665
29GnRH signaling pathway_Homo sapiens_hsa049121.36876178
30Gap junction_Homo sapiens_hsa045401.28360958
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26810026
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21643083
33Oxidative phosphorylation_Homo sapiens_hsa001901.21171465
34cAMP signaling pathway_Homo sapiens_hsa040241.19594254
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17326858
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16103874
37Vibrio cholerae infection_Homo sapiens_hsa051101.12921762
38Alzheimers disease_Homo sapiens_hsa050101.09843220
39Pancreatic secretion_Homo sapiens_hsa049721.06972033
40Estrogen signaling pathway_Homo sapiens_hsa049151.05955344
41Axon guidance_Homo sapiens_hsa043601.04919319
42Type II diabetes mellitus_Homo sapiens_hsa049301.04730126
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02261501
44Melanogenesis_Homo sapiens_hsa049160.96340569
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95599690
46Parkinsons disease_Homo sapiens_hsa050120.95432605
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92970554
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91297236
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.87358978
50Glioma_Homo sapiens_hsa052140.87098874
51ErbB signaling pathway_Homo sapiens_hsa040120.85231391
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85129364
53Phototransduction_Homo sapiens_hsa047440.84531533
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84525564
55Nitrogen metabolism_Homo sapiens_hsa009100.77430644
56Thyroid hormone synthesis_Homo sapiens_hsa049180.77298965
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72844022
58Oocyte meiosis_Homo sapiens_hsa041140.69641057
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.67222616
60Glucagon signaling pathway_Homo sapiens_hsa049220.65919205
61Vitamin B6 metabolism_Homo sapiens_hsa007500.64702608
62Dorso-ventral axis formation_Homo sapiens_hsa043200.63368492
63Bile secretion_Homo sapiens_hsa049760.62215505
64Choline metabolism in cancer_Homo sapiens_hsa052310.60519900
65Huntingtons disease_Homo sapiens_hsa050160.59884209
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59770968
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59608663
68Dilated cardiomyopathy_Homo sapiens_hsa054140.59338771
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56472481
70MAPK signaling pathway_Homo sapiens_hsa040100.55461522
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55116541
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52978380
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51870041
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50581616
75Regulation of autophagy_Homo sapiens_hsa041400.49910611
76Butanoate metabolism_Homo sapiens_hsa006500.48364058
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48278929
78Prion diseases_Homo sapiens_hsa050200.47429241
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47283590
80Ras signaling pathway_Homo sapiens_hsa040140.46607670
81VEGF signaling pathway_Homo sapiens_hsa043700.46460368
82Circadian rhythm_Homo sapiens_hsa047100.46098382
83Type I diabetes mellitus_Homo sapiens_hsa049400.46034022
84Steroid biosynthesis_Homo sapiens_hsa001000.44656776
85Alcoholism_Homo sapiens_hsa050340.43106118
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.41358720
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.40938112
88Arginine biosynthesis_Homo sapiens_hsa002200.40614083
89Rap1 signaling pathway_Homo sapiens_hsa040150.40444357
90Inositol phosphate metabolism_Homo sapiens_hsa005620.38017483
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37280172
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37019243
93Ether lipid metabolism_Homo sapiens_hsa005650.36506949
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35030074
95African trypanosomiasis_Homo sapiens_hsa051430.31860068
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31698283
97Arginine and proline metabolism_Homo sapiens_hsa003300.31484272
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31453596
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31440929
100Insulin signaling pathway_Homo sapiens_hsa049100.30659786
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29847197
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29365208
103Ovarian steroidogenesis_Homo sapiens_hsa049130.28383268
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27885592
105Endocytosis_Homo sapiens_hsa041440.27752801
106Wnt signaling pathway_Homo sapiens_hsa043100.27685507
107beta-Alanine metabolism_Homo sapiens_hsa004100.27645704
108AMPK signaling pathway_Homo sapiens_hsa041520.26919502
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.25802635
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25508426
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25372851
112Phenylalanine metabolism_Homo sapiens_hsa003600.24532044
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24506235
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23407002
115Renal cell carcinoma_Homo sapiens_hsa052110.23360000
116Hippo signaling pathway_Homo sapiens_hsa043900.23140699
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21133843
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19326748

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »