SYT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55044650
2regulation of posttranscriptional gene silencing (GO:0060147)5.40145464
3regulation of gene silencing by miRNA (GO:0060964)5.40145464
4regulation of gene silencing by RNA (GO:0060966)5.40145464
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35820990
6synaptic vesicle maturation (GO:0016188)5.35560077
7locomotory exploration behavior (GO:0035641)5.16950074
8regulation of synapse structural plasticity (GO:0051823)5.10982085
9vocalization behavior (GO:0071625)5.01367835
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.93806565
11prepulse inhibition (GO:0060134)4.87228725
12synaptic vesicle exocytosis (GO:0016079)4.76993270
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.63446505
14protein localization to synapse (GO:0035418)4.52937898
15regulation of synaptic vesicle exocytosis (GO:2000300)4.51868365
16adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.50888981
17regulation of glutamate receptor signaling pathway (GO:1900449)4.45198424
18positive regulation of synaptic transmission, GABAergic (GO:0032230)4.42729464
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.42585798
20negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.41492096
21striatum development (GO:0021756)4.37131321
22regulation of neuronal synaptic plasticity (GO:0048168)4.30840664
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.27801033
24neuronal action potential propagation (GO:0019227)4.27238746
25synaptic transmission, dopaminergic (GO:0001963)4.25320939
26pre-miRNA processing (GO:0031054)4.23734830
27establishment of integrated proviral latency (GO:0075713)4.21341975
28neurotransmitter secretion (GO:0007269)4.18434391
29glutamate secretion (GO:0014047)4.16802287
30neuron cell-cell adhesion (GO:0007158)4.16026790
31ionotropic glutamate receptor signaling pathway (GO:0035235)4.11797049
32presynaptic membrane assembly (GO:0097105)4.06274047
33dopamine receptor signaling pathway (GO:0007212)4.06265558
34L-serine metabolic process (GO:0006563)4.05371343
35synaptic vesicle docking involved in exocytosis (GO:0016081)4.04096542
36neurotransmitter-gated ion channel clustering (GO:0072578)4.02791372
37regulation of synaptic vesicle transport (GO:1902803)4.01052439
38positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.98870291
39exploration behavior (GO:0035640)3.96383086
40negative regulation of dendrite morphogenesis (GO:0050774)3.96247402
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95555874
42auditory behavior (GO:0031223)3.95255185
43negative regulation of dendrite development (GO:2000171)3.90811172
44neuron-neuron synaptic transmission (GO:0007270)3.90143636
45negative regulation of translation, ncRNA-mediated (GO:0040033)3.89991844
46regulation of translation, ncRNA-mediated (GO:0045974)3.89991844
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.89991844
48presynaptic membrane organization (GO:0097090)3.87554303
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.84541393
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.84541393
51neuromuscular process controlling balance (GO:0050885)3.79128562
52transmission of nerve impulse (GO:0019226)3.78775414
53synaptic transmission, glutamatergic (GO:0035249)3.78497230
54layer formation in cerebral cortex (GO:0021819)3.78328683
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.75517439
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73582831
57DNA damage response, detection of DNA damage (GO:0042769)3.72233892
58DNA unwinding involved in DNA replication (GO:0006268)3.71711758
59gamma-aminobutyric acid transport (GO:0015812)3.71657961
60pyrimidine nucleobase catabolic process (GO:0006208)3.71053333
61chromatin remodeling at centromere (GO:0031055)3.70663343
62negative regulation of DNA recombination (GO:0045910)3.70533224
63neuronal action potential (GO:0019228)3.69873812
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68117086
65neuronal ion channel clustering (GO:0045161)3.66616361
66adenosine receptor signaling pathway (GO:0001973)3.65145926
67behavioral response to cocaine (GO:0048148)3.61930072
68response to auditory stimulus (GO:0010996)3.61666075
69positive regulation of membrane potential (GO:0045838)3.61657500
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61078521
71dendritic spine morphogenesis (GO:0060997)3.59922643
72regulation of collateral sprouting (GO:0048670)3.59004351
73response to amphetamine (GO:0001975)3.58959488
74glutamate receptor signaling pathway (GO:0007215)3.58394666
75regulation of dendritic spine morphogenesis (GO:0061001)3.56190829
76membrane depolarization during action potential (GO:0086010)3.55970411
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54716586
78regulation of mitotic spindle checkpoint (GO:1903504)3.54716586
79regulation of sarcomere organization (GO:0060297)3.50509467
80postsynaptic membrane organization (GO:0001941)3.50361662
81regulation of postsynaptic membrane potential (GO:0060078)3.49006132
82peristalsis (GO:0030432)3.48346401
83DNA double-strand break processing (GO:0000729)3.47936312
84regulation of glutamate secretion (GO:0014048)3.47834148
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.47674471
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.47674471
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.47674471
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.47674471
89negative regulation of sister chromatid segregation (GO:0033046)3.47674471
90long-term memory (GO:0007616)3.47606923
91regulation of timing of cell differentiation (GO:0048505)3.43727323
92positive regulation of neurotransmitter transport (GO:0051590)3.42823793
93regulation of synaptic plasticity (GO:0048167)3.40391737
94activation of protein kinase A activity (GO:0034199)3.39742982
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.39522924
96proline transport (GO:0015824)3.37800440
97negative regulation of chromosome segregation (GO:0051985)3.36071613
98regulation of development, heterochronic (GO:0040034)3.35531044
99behavioral defense response (GO:0002209)3.35500312
100behavioral fear response (GO:0001662)3.35500312
101membrane hyperpolarization (GO:0060081)3.35297597
102negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34134636
103regulation of cell fate specification (GO:0042659)3.32905976
104cell migration in hindbrain (GO:0021535)3.32534719
105heterochromatin organization (GO:0070828)3.32216383
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29550927
107substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.29119997
108substrate-independent telencephalic tangential migration (GO:0021826)3.29119997
109CENP-A containing nucleosome assembly (GO:0034080)3.27651737
110mating behavior (GO:0007617)3.27470620
111neurotransmitter transport (GO:0006836)3.27078326
112membrane depolarization (GO:0051899)3.26803092
113regulation of helicase activity (GO:0051095)3.25152752
114paraxial mesoderm development (GO:0048339)3.24552670
115neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.23638459
116glycine transport (GO:0015816)3.23379277
117regulation of synaptic transmission, GABAergic (GO:0032228)3.21653960
118establishment of viral latency (GO:0019043)3.20288493
119long-term synaptic potentiation (GO:0060291)3.19607220
120DNA strand elongation involved in DNA replication (GO:0006271)3.18257036
121cAMP catabolic process (GO:0006198)3.17319101
122regulation of telomere maintenance via telomerase (GO:0032210)3.16311280
123cellular potassium ion homeostasis (GO:0030007)3.15108831
124regulation of neurotransmitter levels (GO:0001505)3.14782103
125positive regulation of neurotransmitter secretion (GO:0001956)3.14699317
126regulation of female receptivity (GO:0045924)3.14337251
127regulation of protein kinase A signaling (GO:0010738)3.13277369
128vesicle transport along microtubule (GO:0047496)3.12662363
129regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.12470735
130regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.12470735
131neuron recognition (GO:0008038)3.12390924
132neuromuscular process (GO:0050905)3.10431983
133neuromuscular process controlling posture (GO:0050884)3.10051125
134protein-cofactor linkage (GO:0018065)3.09349804
135synapse assembly (GO:0007416)3.08881959
136learning (GO:0007612)3.08860809
137visual learning (GO:0008542)3.07052261
138mechanosensory behavior (GO:0007638)3.05232542
139histone exchange (GO:0043486)3.05212134
140regulation of neurotransmitter transport (GO:0051588)3.04597106
141regulation of neurotransmitter secretion (GO:0046928)3.04213069
142neurofilament cytoskeleton organization (GO:0060052)3.03255860
143mitotic spindle checkpoint (GO:0071174)3.02533098
144lung-associated mesenchyme development (GO:0060484)3.02508940
145positive regulation of synapse maturation (GO:0090129)3.01754447
146mitotic spindle assembly checkpoint (GO:0007094)3.00236050
147DNA strand elongation (GO:0022616)2.94302810
148spindle assembly checkpoint (GO:0071173)2.92813057
149lateral sprouting from an epithelium (GO:0060601)2.92226119
150regulation of inclusion body assembly (GO:0090083)2.89484898
151spindle checkpoint (GO:0031577)2.88083339
152regulation of mitotic sister chromatid separation (GO:0010965)2.87847314
153regulation of mitotic sister chromatid segregation (GO:0033047)2.87847314
154regulation of sister chromatid segregation (GO:0033045)2.87847314
155outer ear morphogenesis (GO:0042473)2.87716886
156negative regulation of mitosis (GO:0045839)2.86577646
157regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86541307
158regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86541307
159single strand break repair (GO:0000012)2.86061751
160otic vesicle formation (GO:0030916)2.78541608
161nonmotile primary cilium assembly (GO:0035058)2.77511703
162nucleobase catabolic process (GO:0046113)2.77440866
163establishment of protein localization to mitochondrial membrane (GO:0090151)2.76131680
164DNA replication checkpoint (GO:0000076)2.75471562
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71380012
166regulation of cell fate commitment (GO:0010453)2.70793138
167DNA replication-independent nucleosome organization (GO:0034724)2.69539532
168DNA replication-independent nucleosome assembly (GO:0006336)2.69539532
169negative regulation of inclusion body assembly (GO:0090084)2.67465959
170histone arginine methylation (GO:0034969)2.65786277
171cell fate commitment involved in formation of primary germ layer (GO:0060795)2.60505947
172negative regulation of telomere maintenance (GO:0032205)2.59949706
173regulation of axon regeneration (GO:0048679)2.57926884
174regulation of neuron projection regeneration (GO:0070570)2.57926884
175regulation of telomere maintenance (GO:0032204)2.57429859
176protein localization to kinetochore (GO:0034501)2.56236092
177regulation of mitochondrial translation (GO:0070129)2.54993811
178inner ear receptor cell development (GO:0060119)2.54388865
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.52421247
180negative regulation of nuclear division (GO:0051784)2.52236936
181telomere maintenance via telomerase (GO:0007004)2.52173404
182regulation of chromosome segregation (GO:0051983)2.50808194
183negative regulation of telomerase activity (GO:0051974)2.50580875
184anterior/posterior axis specification, embryo (GO:0008595)2.49731137
185lysine catabolic process (GO:0006554)2.47927480
186lysine metabolic process (GO:0006553)2.47927480
187positive regulation of SMAD protein import into nucleus (GO:0060391)2.47352137
188histone mRNA metabolic process (GO:0008334)2.46302962
189L-alpha-amino acid transmembrane transport (GO:1902475)2.46042536
190serotonin metabolic process (GO:0042428)2.44788293
191kidney morphogenesis (GO:0060993)2.44629925
192negative regulation of DNA-dependent DNA replication (GO:2000104)2.42950841
193ATP-dependent chromatin remodeling (GO:0043044)2.42772894
194negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.40437002
195regulation of chemokine-mediated signaling pathway (GO:0070099)2.38659455
196serine family amino acid biosynthetic process (GO:0009070)2.38270135
197cerebral cortex radially oriented cell migration (GO:0021799)2.38148935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.55724863
2E2F7_22180533_ChIP-Seq_HELA_Human5.43502632
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.05794364
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.72485730
5GBX2_23144817_ChIP-Seq_PC3_Human3.36041488
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19871275
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11937216
8POU5F1_16153702_ChIP-ChIP_HESCs_Human3.08515994
9* RARB_27405468_Chip-Seq_BRAIN_Mouse3.08441228
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02998564
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.02991935
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.02991935
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.02991935
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77455012
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77455012
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73058153
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.66782527
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.63027638
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62056015
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59608508
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54110398
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53048551
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.48587712
24SOX2_16153702_ChIP-ChIP_HESCs_Human2.43981155
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39733986
26DROSHA_22980978_ChIP-Seq_HELA_Human2.39572675
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27361002
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27101123
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26900788
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.19011796
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18744080
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16111030
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15347060
34* EED_16625203_ChIP-ChIP_MESCs_Mouse2.13663651
35AR_21572438_ChIP-Seq_LNCaP_Human2.12158138
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11069983
37E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04876665
38IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03606913
39NANOG_16153702_ChIP-ChIP_HESCs_Human2.01333210
40* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98245406
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98220334
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97284746
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90739951
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86585008
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86585008
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.85771794
47TAF15_26573619_Chip-Seq_HEK293_Human1.85722945
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85441129
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85353779
50EWS_26573619_Chip-Seq_HEK293_Human1.68364320
51FUS_26573619_Chip-Seq_HEK293_Human1.67263366
52* ERG_21242973_ChIP-ChIP_JURKAT_Human1.65266225
53* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62207271
54VDR_22108803_ChIP-Seq_LS180_Human1.61886923
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61329397
56SMAD4_21799915_ChIP-Seq_A2780_Human1.60400568
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59637360
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59263710
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.57527041
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.55757247
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.50288747
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48765413
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46968026
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46810287
65MYC_18940864_ChIP-ChIP_HL60_Human1.46765849
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46103493
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42217006
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40877750
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.38084755
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37576661
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.37492722
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37321429
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35537948
74POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.34990501
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33580673
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.33035564
77ELK1_19687146_ChIP-ChIP_HELA_Human1.30343183
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30247189
79* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29930967
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.29862377
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.29414951
82IRF1_19129219_ChIP-ChIP_H3396_Human1.28790547
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.28465508
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28428586
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28414203
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27881559
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27542429
88P300_19829295_ChIP-Seq_ESCs_Human1.27508638
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27192721
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25791209
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25744168
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25392102
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.24217308
94AR_19668381_ChIP-Seq_PC3_Human1.23771213
95* STAT3_23295773_ChIP-Seq_U87_Human1.21717245
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21303464
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20717602
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20380216
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20071862
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.19634954
101KDM2B_26808549_Chip-Seq_K562_Human1.19104253
102AHR_22903824_ChIP-Seq_MCF-7_Human1.19059187
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18914407
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17930396
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.16447137
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16299224
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16016940
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15497897
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.15309540
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14955495
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14863635
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14685236
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14418872
114ZNF274_21170338_ChIP-Seq_K562_Hela1.14323768
115ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13889624
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13308263
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.12975898
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.12340647
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11250516
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10330460
121TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10149006
122AR_25329375_ChIP-Seq_VCAP_Human1.10113847
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09852543
124* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09578059
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08412622
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.07750325
127PIAS1_25552417_ChIP-Seq_VCAP_Human1.07328590
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06911455
129WT1_19549856_ChIP-ChIP_CCG9911_Human1.06858311
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06773535
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06695211
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05717172
133* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04962579
134* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04044137
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03901184
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03236108
137* TCF4_23295773_ChIP-Seq_U87_Human1.02485881
138RNF2_27304074_Chip-Seq_NSC_Mouse1.02212226
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01468094
140SMAD3_21741376_ChIP-Seq_ESCs_Human1.00890944
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99844424
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99509451
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.99249054
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98608951
145RUNX2_22187159_ChIP-Seq_PCA_Human0.98401543
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96650278
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.95720703
148TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95604888
149ETS1_20019798_ChIP-Seq_JURKAT_Human0.94756206
150* CTCF_27219007_Chip-Seq_Bcells_Human0.94165193
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93428430
152HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93338445
153* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93201575
154BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92879152
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.92055717
156NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91639519
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91450252
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91219516
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89766246
160IGF1R_20145208_ChIP-Seq_DFB_Human0.88316028
161* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87573488
162* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87209005
163TET1_21490601_ChIP-Seq_MESCs_Mouse0.86963185
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86679053
165PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86127258
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85971156
167FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85873097
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.85493301
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85438947
170JUN_21703547_ChIP-Seq_K562_Human0.84985948
171ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84867376
172* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84608449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.32594807
2MP0004859_abnormal_synaptic_plasticity5.70411711
3MP0003880_abnormal_central_pattern4.18466812
4MP0003635_abnormal_synaptic_transmissio3.96163997
5MP0004270_analgesia3.69178529
6MP0001968_abnormal_touch/_nociception3.66583196
7MP0008877_abnormal_DNA_methylation3.61959489
8MP0009745_abnormal_behavioral_response3.38461698
9MP0002063_abnormal_learning/memory/cond3.23729033
10MP0002735_abnormal_chemical_nociception2.96832128
11MP0002736_abnormal_nociception_after2.93635613
12MP0002064_seizures2.92378690
13MP0006292_abnormal_olfactory_placode2.88901799
14MP0009046_muscle_twitch2.87452263
15MP0003136_yellow_coat_color2.83962082
16MP0002734_abnormal_mechanical_nocicepti2.77234712
17MP0005423_abnormal_somatic_nervous2.66236666
18MP0002572_abnormal_emotion/affect_behav2.65540892
19MP0002272_abnormal_nervous_system2.63974099
20MP0002254_reproductive_system_inflammat2.58648823
21MP0001486_abnormal_startle_reflex2.53725741
22MP0005171_absent_coat_pigmentation2.50148527
23MP0002733_abnormal_thermal_nociception2.49122256
24MP0003941_abnormal_skin_development2.46890465
25MP0003195_calcinosis2.45932600
26MP0002102_abnormal_ear_morphology2.36374505
27MP0001970_abnormal_pain_threshold2.31936855
28MP0010094_abnormal_chromosome_stability2.31582921
29MP0008057_abnormal_DNA_replication2.27280551
30MP0001529_abnormal_vocalization2.14366499
31MP0008058_abnormal_DNA_repair2.10879055
32MP0000049_abnormal_middle_ear2.08985206
33MP0009697_abnormal_copulation2.07208494
34MP0003890_abnormal_embryonic-extraembry2.00654014
35MP0000566_synostosis2.00029241
36MP0009672_abnormal_birth_weight2.00012594
37MP0002909_abnormal_adrenal_gland1.98245488
38MP0004858_abnormal_nervous_system1.96964913
39MP0001501_abnormal_sleep_pattern1.96065886
40MP0003121_genomic_imprinting1.94766566
41MP0008789_abnormal_olfactory_epithelium1.94484361
42MP0002067_abnormal_sensory_capabilities1.94168839
43MP0003718_maternal_effect1.93575005
44MP0006276_abnormal_autonomic_nervous1.88990001
45MP0005386_behavior/neurological_phenoty1.88824997
46MP0004924_abnormal_behavior1.88824997
47MP0002184_abnormal_innervation1.85946638
48MP0003111_abnormal_nucleus_morphology1.84189491
49MP0004811_abnormal_neuron_physiology1.82540581
50MP0004133_heterotaxia1.75156321
51MP0002557_abnormal_social/conspecific_i1.74260065
52MP0008569_lethality_at_weaning1.72260537
53MP0005646_abnormal_pituitary_gland1.71834617
54MP0004957_abnormal_blastocyst_morpholog1.69065969
55MP0001984_abnormal_olfaction1.66907149
56MP0001293_anophthalmia1.65945183
57MP0001440_abnormal_grooming_behavior1.63837637
58MP0003693_abnormal_embryo_hatching1.60986167
59MP0003567_abnormal_fetal_cardiomyocyte1.59308203
60MP0000778_abnormal_nervous_system1.58575894
61MP0005377_hearing/vestibular/ear_phenot1.58418943
62MP0003878_abnormal_ear_physiology1.58418943
63MP0003879_abnormal_hair_cell1.58040010
64MP0000955_abnormal_spinal_cord1.55515376
65MP0000372_irregular_coat_pigmentation1.55250809
66MP0009780_abnormal_chondrocyte_physiolo1.54251871
67MP0003937_abnormal_limbs/digits/tail_de1.49553961
68MP0008932_abnormal_embryonic_tissue1.49167923
69MP0006072_abnormal_retinal_apoptosis1.44743869
70MP0003329_amyloid_beta_deposits1.41337589
71MP0002233_abnormal_nose_morphology1.40818794
72MP0003119_abnormal_digestive_system1.40420042
73MP0003787_abnormal_imprinting1.36941976
74MP0001188_hyperpigmentation1.36624280
75MP0002066_abnormal_motor_capabilities/c1.35406594
76MP0002882_abnormal_neuron_morphology1.35061780
77MP0009278_abnormal_bone_marrow1.31740437
78MP0004885_abnormal_endolymph1.29108798
79MP0003938_abnormal_ear_development1.25007482
80MP0010030_abnormal_orbit_morphology1.24282401
81MP0003633_abnormal_nervous_system1.24115222
82MP0000647_abnormal_sebaceous_gland1.23672915
83MP0001286_abnormal_eye_development1.22538938
84MP0003077_abnormal_cell_cycle1.21297280
85MP0002697_abnormal_eye_size1.18616355
86MP0001905_abnormal_dopamine_level1.13043139
87MP0000569_abnormal_digit_pigmentation1.12940508
88MP0008007_abnormal_cellular_replicative1.12475575
89MP0005409_darkened_coat_color1.11573951
90MP0002085_abnormal_embryonic_tissue1.11308722
91MP0004142_abnormal_muscle_tone1.10728473
92MP0006035_abnormal_mitochondrial_morpho1.09233607
93MP0009703_decreased_birth_body1.07854004
94MP0001177_atelectasis1.06377121
95MP0008874_decreased_physiological_sensi1.04279121
96MP0002084_abnormal_developmental_patter1.02811623
97MP0002111_abnormal_tail_morphology1.02207986
98MP0005645_abnormal_hypothalamus_physiol1.01624578
99MP0003631_nervous_system_phenotype1.01549807
100MP0008872_abnormal_physiological_respon1.01507944
101MP0003123_paternal_imprinting1.01157585
102MP0003122_maternal_imprinting1.00835702
103MP0003755_abnormal_palate_morphology0.99747458
104MP0004085_abnormal_heartbeat0.98096402
105MP0000751_myopathy0.97834871
106MP0002152_abnormal_brain_morphology0.97614137
107MP0004197_abnormal_fetal_growth/weight/0.94710069
108MP0001502_abnormal_circadian_rhythm0.94698123
109MP0000579_abnormal_nail_morphology0.94278101
110MP0002069_abnormal_eating/drinking_beha0.92830926
111MP0008961_abnormal_basal_metabolism0.92616107
112MP0002229_neurodegeneration0.92244614
113MP0000013_abnormal_adipose_tissue0.92185162
114MP0002938_white_spotting0.91384276
115MP0000428_abnormal_craniofacial_morphol0.91340238
116MP0003283_abnormal_digestive_organ0.86547977
117MP0003186_abnormal_redox_activity0.84198721
118MP0005167_abnormal_blood-brain_barrier0.82317468
119MP0003075_altered_response_to0.82234738
120MP0005253_abnormal_eye_physiology0.81458603
121MP0001730_embryonic_growth_arrest0.81437763
122MP0003634_abnormal_glial_cell0.78783325
123MP0001299_abnormal_eye_distance/0.78103971
124MP0005499_abnormal_olfactory_system0.76659509
125MP0005394_taste/olfaction_phenotype0.76659509
126MP0000537_abnormal_urethra_morphology0.76133094
127MP0001485_abnormal_pinna_reflex0.76028118
128MP0000026_abnormal_inner_ear0.75846123
129MP0002081_perinatal_lethality0.75370505
130MP0002752_abnormal_somatic_nervous0.73291983
131MP0004742_abnormal_vestibular_system0.73191117
132MP0001986_abnormal_taste_sensitivity0.72757432
133MP0002751_abnormal_autonomic_nervous0.72524560
134MP0004215_abnormal_myocardial_fiber0.71751015
135MP0001963_abnormal_hearing_physiology0.70944057
136MP0005535_abnormal_body_temperature0.70884066
137MP0000920_abnormal_myelination0.70697305
138MP0003137_abnormal_impulse_conducting0.70030999
139MP0003690_abnormal_glial_cell0.69038076
140MP0010234_abnormal_vibrissa_follicle0.68849803
141MP0000631_abnormal_neuroendocrine_gland0.67403991
142MP0000534_abnormal_ureter_morphology0.63961776
143MP0002638_abnormal_pupillary_reflex0.62977420
144MP0003632_abnormal_nervous_system0.61968187
145MP0005551_abnormal_eye_electrophysiolog0.61452684
146MP0002090_abnormal_vision0.61418487
147MP0004145_abnormal_muscle_electrophysio0.60092217
148MP0001664_abnormal_digestion0.59861303
149MP0001943_abnormal_respiration0.57849091
150MP0000604_amyloidosis0.56424582
151MP0002653_abnormal_ependyma_morphology0.56255214
152MP0010386_abnormal_urinary_bladder0.50101457
153MP0003956_abnormal_body_size0.49159431
154MP0003861_abnormal_nervous_system0.48075122
155MP0010769_abnormal_survival0.46749872
156MP0002082_postnatal_lethality0.46482708
157MP0010770_preweaning_lethality0.46482708
158MP0010768_mortality/aging0.43037490
159MP0004036_abnormal_muscle_relaxation0.37250140

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.94154436
2Focal motor seizures (HP:0011153)6.89616317
3Focal seizures (HP:0007359)5.56003300
4Abnormality of the labia minora (HP:0012880)5.49978340
5Stenosis of the external auditory canal (HP:0000402)4.57584720
6Action tremor (HP:0002345)4.42216768
7Visual hallucinations (HP:0002367)4.15055729
8Epileptic encephalopathy (HP:0200134)4.00708104
9Septo-optic dysplasia (HP:0100842)4.00671583
10Ankle clonus (HP:0011448)3.83364239
11Febrile seizures (HP:0002373)3.77837495
12Atonic seizures (HP:0010819)3.75899231
13Colon cancer (HP:0003003)3.66199951
14Torticollis (HP:0000473)3.59500198
15Ependymoma (HP:0002888)3.57832387
16Progressive cerebellar ataxia (HP:0002073)3.50525779
17Poor eye contact (HP:0000817)3.42978459
18Absence seizures (HP:0002121)3.40988510
19Generalized tonic-clonic seizures (HP:0002069)3.40729346
20Depression (HP:0000716)3.34910603
21Impaired vibration sensation in the lower limbs (HP:0002166)3.32167906
22Impaired social interactions (HP:0000735)3.25143668
23Abnormal social behavior (HP:0012433)3.25143668
24Focal dystonia (HP:0004373)3.20541130
25Anxiety (HP:0000739)3.19645266
26Dialeptic seizures (HP:0011146)3.17730760
27Broad-based gait (HP:0002136)3.17632193
28Urinary bladder sphincter dysfunction (HP:0002839)3.16282008
29Hepatoblastoma (HP:0002884)3.14893903
30Supranuclear gaze palsy (HP:0000605)3.14202928
31Gaze-evoked nystagmus (HP:0000640)3.11765371
32Aplasia/Hypoplasia of the sternum (HP:0006714)3.11498028
33Annular pancreas (HP:0001734)3.11408004
34Craniofacial dystonia (HP:0012179)3.09645219
35Truncal ataxia (HP:0002078)3.07495016
36Urinary urgency (HP:0000012)3.05106718
37Resting tremor (HP:0002322)3.02752694
38Absent septum pellucidum (HP:0001331)3.02559531
39Maternal diabetes (HP:0009800)3.01984365
40Optic nerve hypoplasia (HP:0000609)2.95830039
41Dysdiadochokinesis (HP:0002075)2.93154169
42Scanning speech (HP:0002168)2.89898602
43Insidious onset (HP:0003587)2.86271265
44Termporal pattern (HP:0011008)2.86271265
45Abnormality of the septum pellucidum (HP:0007375)2.86236652
46Papilledema (HP:0001085)2.85736986
47Hypothermia (HP:0002045)2.85034828
48Limb dystonia (HP:0002451)2.81479122
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.78453995
50Abnormal eating behavior (HP:0100738)2.78281983
51Agnosia (HP:0010524)2.75070859
52Medulloblastoma (HP:0002885)2.67144818
53Progressive inability to walk (HP:0002505)2.66601163
54Pheochromocytoma (HP:0002666)2.65186874
55Postural instability (HP:0002172)2.64591424
56Esophageal atresia (HP:0002032)2.64318878
57Dysmetria (HP:0001310)2.64030800
58Spastic gait (HP:0002064)2.63676537
59Birth length less than 3rd percentile (HP:0003561)2.62620150
60Amblyopia (HP:0000646)2.62208416
61Stereotypic behavior (HP:0000733)2.61305532
62Mutism (HP:0002300)2.58519651
63Hyperventilation (HP:0002883)2.53594940
64Pendular nystagmus (HP:0012043)2.53584447
65Pointed chin (HP:0000307)2.51642731
66Dysmetric saccades (HP:0000641)2.51535840
67Glioma (HP:0009733)2.49816354
68Spinal muscular atrophy (HP:0007269)2.45040144
69Impaired smooth pursuit (HP:0007772)2.44702580
70Bilateral microphthalmos (HP:0007633)2.42178058
71Hyperglycinuria (HP:0003108)2.41271832
72Choanal stenosis (HP:0000452)2.38495187
73Abnormality of the astrocytes (HP:0100707)2.37324278
74Astrocytoma (HP:0009592)2.37324278
75Gastrointestinal atresia (HP:0002589)2.36828827
76Bradykinesia (HP:0002067)2.35563055
77Abnormality of the lower motor neuron (HP:0002366)2.35078260
78Abnormality of cochlea (HP:0000375)2.34512847
79Abnormality of pain sensation (HP:0010832)2.33901423
80Impaired pain sensation (HP:0007328)2.33901423
81Lower limb amyotrophy (HP:0007210)2.32925927
82Failure to thrive in infancy (HP:0001531)2.32565217
83Abnormal hair whorl (HP:0010721)2.31931867
84Homocystinuria (HP:0002156)2.27202749
85Abnormality of homocysteine metabolism (HP:0010919)2.27202749
86Megalencephaly (HP:0001355)2.26911134
87Ulnar claw (HP:0001178)2.25338932
88Diastasis recti (HP:0001540)2.25147189
89Neuroendocrine neoplasm (HP:0100634)2.23723584
90Breast aplasia (HP:0100783)2.23475048
91Morphological abnormality of the inner ear (HP:0011390)2.22724145
92Cortical dysplasia (HP:0002539)2.22558747
93Prolonged QT interval (HP:0001657)2.22366899
94Impaired vibratory sensation (HP:0002495)2.21059635
95Hyperglycinemia (HP:0002154)2.19837855
96Ankyloglossia (HP:0010296)2.19742557
97Intention tremor (HP:0002080)2.17807233
98Fetal akinesia sequence (HP:0001989)2.17706725
99Lower limb muscle weakness (HP:0007340)2.16935984
100Abnormality of the corticospinal tract (HP:0002492)2.16927104
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.15739127
102Rhabdomyosarcoma (HP:0002859)2.15709498
103Excessive salivation (HP:0003781)2.15504160
104Drooling (HP:0002307)2.15504160
105Hypoplastic female external genitalia (HP:0012815)2.14754082
106Epileptiform EEG discharges (HP:0011182)2.14621717
107Meckel diverticulum (HP:0002245)2.13597299
108EEG with generalized epileptiform discharges (HP:0011198)2.13385841
109Labial hypoplasia (HP:0000066)2.12352904
110Humeroradial synostosis (HP:0003041)2.11241206
111Synostosis involving the elbow (HP:0003938)2.11241206
112Clonus (HP:0002169)2.10923394
113Hypsarrhythmia (HP:0002521)2.09722858
114Genetic anticipation (HP:0003743)2.09351234
115Partial duplication of thumb phalanx (HP:0009944)2.09249980
116Abnormality of ocular smooth pursuit (HP:0000617)2.09130670
117Abnormal EKG (HP:0003115)2.08956458
118Peripheral hypomyelination (HP:0007182)2.08810846
119Hammertoe (HP:0001765)2.06678216
120Incomplete penetrance (HP:0003829)2.06240411
121Ventricular fibrillation (HP:0001663)2.05815603
122Aplasia/Hypoplasia of the breasts (HP:0010311)2.05171600
123Abnormality of serine family amino acid metabolism (HP:0010894)2.04111742
124Abnormality of glycine metabolism (HP:0010895)2.04111742
125Hemiparesis (HP:0001269)2.04022667
126Broad foot (HP:0001769)2.03874342
127Split foot (HP:0001839)2.03444213
128Abolished electroretinogram (ERG) (HP:0000550)2.02537838
129Intestinal atresia (HP:0011100)2.02395753
130Broad thumb (HP:0011304)2.01341106
131Hypoventilation (HP:0002791)2.00151451
132Growth hormone deficiency (HP:0000824)1.98408459
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97023174
134Bronchomalacia (HP:0002780)1.96935993
135Genital tract atresia (HP:0001827)1.95095710
136Insomnia (HP:0100785)1.93430825
137Neurofibrillary tangles (HP:0002185)1.93429503
138Patellar aplasia (HP:0006443)1.93206227
139Abnormality of the ileum (HP:0001549)1.92510200
140Neoplasm of the peripheral nervous system (HP:0100007)1.91673381
141Anophthalmia (HP:0000528)1.91606466
142Status epilepticus (HP:0002133)1.91447508
143Onion bulb formation (HP:0003383)1.90437342
144Spastic diplegia (HP:0001264)1.88438105
145Neuronal loss in central nervous system (HP:0002529)1.88224566
146Lower limb asymmetry (HP:0100559)1.87222585
147Vaginal atresia (HP:0000148)1.86694765
148Facial cleft (HP:0002006)1.85575472
149Bladder neoplasm (HP:0009725)1.84440884
150Bladder carcinoma (HP:0002862)1.84440884
151Spinal canal stenosis (HP:0003416)1.84209549
152Abnormality of serum amino acid levels (HP:0003112)1.83874873
153Abnormal lung lobation (HP:0002101)1.83284307
154Absent speech (HP:0001344)1.82942934
155Nephroblastoma (Wilms tumor) (HP:0002667)1.80609794
156Abnormality of the clitoris (HP:0000056)1.80427930
157Inability to walk (HP:0002540)1.80157607
158Biliary tract neoplasm (HP:0100574)1.79923398
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.79390036
160Malignant gastrointestinal tract tumors (HP:0006749)1.77890160
161Gastrointestinal carcinoma (HP:0002672)1.77890160
162Blue irides (HP:0000635)1.77586572
163Hemivertebrae (HP:0002937)1.77464221
164Hypoplasia of the brainstem (HP:0002365)1.77441568
165Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77441568
166Aqueductal stenosis (HP:0002410)1.76460683
167Generalized hypotonia (HP:0001290)1.76427223
168Cerebral inclusion bodies (HP:0100314)1.76052919
169Myelomeningocele (HP:0002475)1.75341907
170Polyphagia (HP:0002591)1.75341049
171Abnormality of chromosome stability (HP:0003220)1.75002426
172Hemiplegia (HP:0002301)1.74812467
173Partial duplication of the phalanx of hand (HP:0009999)1.74260590
174Lissencephaly (HP:0001339)1.73500985
175Renal hypoplasia (HP:0000089)1.71784173
176Chromsome breakage (HP:0040012)1.71405465
177Abnormality of the carotid arteries (HP:0005344)1.70985455
178Rigidity (HP:0002063)1.70316551
179Aplasia/Hypoplasia of the patella (HP:0006498)1.70102288
180Triphalangeal thumb (HP:0001199)1.69183793
181Rectal fistula (HP:0100590)1.68206270
182Rectovaginal fistula (HP:0000143)1.68206270
183Bifid tongue (HP:0010297)1.68129536
184Scrotal hypoplasia (HP:0000046)1.67785127
185Cutaneous syndactyly (HP:0012725)1.67758270
186Embryonal renal neoplasm (HP:0011794)1.67415414
187Micropenis (HP:0000054)1.66050497
188Aplasia/Hypoplasia of the uvula (HP:0010293)1.65386737
189Carpal bone hypoplasia (HP:0001498)1.64365440
190Absent eyebrow (HP:0002223)1.64062342
191Cutaneous finger syndactyly (HP:0010554)1.63884922
192Neoplasm of striated muscle (HP:0009728)1.63855342
193Stomach cancer (HP:0012126)1.63316304
194Glossoptosis (HP:0000162)1.62822075
195Abnormality of the antihelix (HP:0009738)1.60940797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.25630620
2NTRK34.35925277
3CAMK1D4.12977789
4MAP3K93.72514984
5TSSK63.56474628
6CAMK1G3.49595251
7CDC73.35089403
8MINK12.76685748
9MARK12.74847534
10MAP3K42.64137987
11KSR22.59763945
12PRKD32.57652644
13STK38L2.43926902
14RIPK42.34338556
15NTRK12.33601467
16DAPK22.33408525
17DYRK22.24834499
18MAP2K72.12582085
19MKNK22.09905401
20TTK2.01902018
21CAMKK12.01876317
22KSR11.96321010
23PLK31.95991091
24ZAK1.92506266
25MKNK11.86084895
26BUB11.85474815
27NTRK21.84414838
28PAK61.81633093
29CASK1.77018301
30ARAF1.74660649
31CAMKK21.61750043
32MAPK131.60116595
33MAP2K41.57034695
34CDK51.56751193
35SIK31.46103681
36SRPK11.45536153
37TRIM281.43301761
38MAP3K21.43080834
39VRK11.41853619
40MAP3K101.40847985
41MAP3K121.40567755
42PLK41.39519928
43TAF11.37628869
44SIK21.34271383
45FES1.33315244
46TAOK11.32628728
47BMPR1B1.32477041
48PLK11.32141780
49TNIK1.32119788
50SGK2231.27430614
51SGK4941.27430614
52DAPK11.25140015
53DYRK31.23501323
54UHMK11.20624136
55MAP3K131.20372949
56SGK21.19504809
57MAP4K21.13870272
58CSNK1G11.11057486
59RET1.08331941
60TYRO31.06221017
61WEE11.03953773
62PRPF4B1.02583701
63CDK191.02097944
64VRK21.01979402
65PRKCH1.01653725
66SGK31.00526624
67LMTK20.99880096
68PRKCG0.99249554
69CSNK1G30.98604016
70NME10.95486709
71GRK50.95329627
72MAPK150.93779384
73CDK180.89833017
74STK380.89670609
75INSRR0.88249670
76CDK140.88116998
77PLK20.87820912
78PHKG20.87284173
79PHKG10.87284173
80CHEK20.87219131
81PINK10.86956398
82CSNK1A1L0.86567411
83RAF10.86024932
84MAPKAPK50.84855046
85BRSK20.83639145
86CAMK2A0.83194029
87NUAK10.82928098
88STK110.81964162
89CDK150.81471244
90EPHB20.81158218
91ATR0.79647220
92BCKDK0.78976886
93FGFR10.77276310
94TAOK30.76141321
95LATS20.75259878
96BMX0.74160895
97MARK20.74071863
98ATM0.73073235
99SGK10.71489138
100CDK11A0.70199590
101DMPK0.68577443
102MAP3K10.68081927
103MAP2K10.67989185
104CAMK10.67647867
105RPS6KA20.65627864
106PNCK0.64428117
107BMPR20.64238040
108PTK2B0.62353771
109ADRBK20.62249644
110CSNK1E0.61359001
111NEK20.61063706
112BCR0.61063593
113LIMK10.61058046
114CAMK2B0.60649473
115DDR20.59750324
116ALK0.59555294
117PDPK10.59334943
118CSNK1G20.58558557
119PDK10.58277818
120CDC42BPA0.58276024
121CDK30.57967284
122NEK10.56859162
123WNK10.56282417
124GRK10.55896500
125NLK0.55571375
126BRSK10.55118785
127PRKCZ0.55012696
128TIE10.54910189
129CAMK40.54385172
130EIF2AK10.53175315
131SCYL20.51823421
132CDK10.51210552
133CSNK1D0.50524721
134RPS6KA30.48909677
135TNK20.48235154
136MAPK100.47917175
137OXSR10.47792130
138CDK20.46668078
139PRKCE0.46371299
140DYRK1A0.45462507
141PRKDC0.45060548
142BRAF0.44622336
143EGFR0.43790436
144EIF2AK30.43126847
145CSNK2A10.42619376
146MAPK90.42364201
147PAK30.41800801
148RPS6KA10.41665322
149FGFR20.41532582
150FYN0.41198595
151AURKB0.39389600
152TEC0.39060007
153NEK60.37819774
154PASK0.36315276
155CAMK2G0.35331465
156CSNK2A20.35175965
157CHEK10.35079325
158EIF2AK20.34673128
159ROCK10.34501818
160MAPK80.32798392
161* PRKCB0.31943478
162GSK3B0.31646147
163AURKA0.31061787
164TGFBR10.30889519
165INSR0.30692888
166PRKACA0.29277329
167WNK30.29140514
168CAMK2D0.28575333
169CSNK1A10.28187496

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.33045045
2Mismatch repair_Homo sapiens_hsa034303.15968013
3Synaptic vesicle cycle_Homo sapiens_hsa047213.13798933
4DNA replication_Homo sapiens_hsa030303.04694978
5Nicotine addiction_Homo sapiens_hsa050333.02368042
6Morphine addiction_Homo sapiens_hsa050322.66002681
7GABAergic synapse_Homo sapiens_hsa047272.63243569
8Circadian entrainment_Homo sapiens_hsa047132.60847582
9Amphetamine addiction_Homo sapiens_hsa050312.47368428
10Long-term potentiation_Homo sapiens_hsa047202.44752017
11Glutamatergic synapse_Homo sapiens_hsa047242.43606655
12Selenocompound metabolism_Homo sapiens_hsa004502.38692349
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37155998
14Dopaminergic synapse_Homo sapiens_hsa047282.37038126
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35694323
16Non-homologous end-joining_Homo sapiens_hsa034502.35061080
17RNA polymerase_Homo sapiens_hsa030202.31099120
18Proteasome_Homo sapiens_hsa030502.21578584
19Cocaine addiction_Homo sapiens_hsa050302.18255327
20Spliceosome_Homo sapiens_hsa030402.18110397
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15111310
22Cholinergic synapse_Homo sapiens_hsa047252.15046319
23Fanconi anemia pathway_Homo sapiens_hsa034602.05848677
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03835502
25Cysteine and methionine metabolism_Homo sapiens_hsa002702.03346172
26Salivary secretion_Homo sapiens_hsa049702.00224685
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95339269
28Cell cycle_Homo sapiens_hsa041101.94656973
29RNA transport_Homo sapiens_hsa030131.94208464
30Insulin secretion_Homo sapiens_hsa049111.88051416
31Protein export_Homo sapiens_hsa030601.85232228
32Steroid biosynthesis_Homo sapiens_hsa001001.82304473
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78005705
34One carbon pool by folate_Homo sapiens_hsa006701.76544057
35Renin secretion_Homo sapiens_hsa049241.74814017
36Taste transduction_Homo sapiens_hsa047421.69211057
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68359845
38Gastric acid secretion_Homo sapiens_hsa049711.68114677
39Serotonergic synapse_Homo sapiens_hsa047261.64255069
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60862614
41Oxidative phosphorylation_Homo sapiens_hsa001901.60721817
42Parkinsons disease_Homo sapiens_hsa050121.60402974
43Oxytocin signaling pathway_Homo sapiens_hsa049211.59480798
44Homologous recombination_Homo sapiens_hsa034401.59294820
45Long-term depression_Homo sapiens_hsa047301.58801020
46Calcium signaling pathway_Homo sapiens_hsa040201.58010707
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56555733
48Gap junction_Homo sapiens_hsa045401.54699016
49RNA degradation_Homo sapiens_hsa030181.53381606
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52277210
51Huntingtons disease_Homo sapiens_hsa050161.44206586
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42089079
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41545523
54GnRH signaling pathway_Homo sapiens_hsa049121.40384088
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37931645
56Basal transcription factors_Homo sapiens_hsa030221.31436427
57mRNA surveillance pathway_Homo sapiens_hsa030151.30728497
58cAMP signaling pathway_Homo sapiens_hsa040241.27005841
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24392448
60Nucleotide excision repair_Homo sapiens_hsa034201.21529899
61Base excision repair_Homo sapiens_hsa034101.19846992
62Glioma_Homo sapiens_hsa052141.19288253
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17814865
64Collecting duct acid secretion_Homo sapiens_hsa049661.17498622
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15636651
66Basal cell carcinoma_Homo sapiens_hsa052171.14510424
67Type II diabetes mellitus_Homo sapiens_hsa049301.13874642
68Propanoate metabolism_Homo sapiens_hsa006401.13248422
69Axon guidance_Homo sapiens_hsa043601.08437520
70Estrogen signaling pathway_Homo sapiens_hsa049151.06495621
71ErbB signaling pathway_Homo sapiens_hsa040121.04563693
72Melanogenesis_Homo sapiens_hsa049161.03409563
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03164283
74Sulfur relay system_Homo sapiens_hsa041221.02871082
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01574162
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01361206
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98754885
78Phototransduction_Homo sapiens_hsa047440.98482070
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95998365
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95210145
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.93830456
82Dorso-ventral axis formation_Homo sapiens_hsa043200.93766549
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93189376
84Oocyte meiosis_Homo sapiens_hsa041140.92129980
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.91120017
86Hippo signaling pathway_Homo sapiens_hsa043900.90838268
87Tight junction_Homo sapiens_hsa045300.89718017
88Pyruvate metabolism_Homo sapiens_hsa006200.88994635
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87848008
90Nitrogen metabolism_Homo sapiens_hsa009100.85526598
91Vitamin digestion and absorption_Homo sapiens_hsa049770.84156301
92Alzheimers disease_Homo sapiens_hsa050100.82961178
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.82709181
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82568630
95Cardiac muscle contraction_Homo sapiens_hsa042600.82387784
96Biosynthesis of amino acids_Homo sapiens_hsa012300.81570756
97Retinol metabolism_Homo sapiens_hsa008300.81113513
98Hedgehog signaling pathway_Homo sapiens_hsa043400.80457019
99Adherens junction_Homo sapiens_hsa045200.80399125
100Vibrio cholerae infection_Homo sapiens_hsa051100.78610077
101Purine metabolism_Homo sapiens_hsa002300.75744625
102Alcoholism_Homo sapiens_hsa050340.75730419
103Ribosome_Homo sapiens_hsa030100.75662089
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74805671
105Thyroid hormone synthesis_Homo sapiens_hsa049180.74732821
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73312503
107Non-small cell lung cancer_Homo sapiens_hsa052230.73297918
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73066757
109Rap1 signaling pathway_Homo sapiens_hsa040150.72796455
110Pancreatic secretion_Homo sapiens_hsa049720.72527042
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71657328
112MAPK signaling pathway_Homo sapiens_hsa040100.70745471
113Dilated cardiomyopathy_Homo sapiens_hsa054140.69558749
114Choline metabolism in cancer_Homo sapiens_hsa052310.68343141
115Vitamin B6 metabolism_Homo sapiens_hsa007500.66776910
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65179438
117Endometrial cancer_Homo sapiens_hsa052130.64983417
118Glutathione metabolism_Homo sapiens_hsa004800.64615338
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64100329
120Arginine and proline metabolism_Homo sapiens_hsa003300.62501996
121VEGF signaling pathway_Homo sapiens_hsa043700.62400983
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62388402
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61562516
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61408645
125Pyrimidine metabolism_Homo sapiens_hsa002400.60207987
126Ras signaling pathway_Homo sapiens_hsa040140.59415841
127Type I diabetes mellitus_Homo sapiens_hsa049400.58753815
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57363505
129mTOR signaling pathway_Homo sapiens_hsa041500.56668325
130Mineral absorption_Homo sapiens_hsa049780.56603543
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56425957
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.53231209
133Endocytosis_Homo sapiens_hsa041440.52153769
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50334597
135Glucagon signaling pathway_Homo sapiens_hsa049220.50162531
136TGF-beta signaling pathway_Homo sapiens_hsa043500.49347009
137Insulin signaling pathway_Homo sapiens_hsa049100.47703108
138Bile secretion_Homo sapiens_hsa049760.47378806
139Lysine degradation_Homo sapiens_hsa003100.46721306
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46687761
141Thyroid cancer_Homo sapiens_hsa052160.46436343
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43905410
143Chemokine signaling pathway_Homo sapiens_hsa040620.43757298
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43430637
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43332361
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42955096
147Prion diseases_Homo sapiens_hsa050200.42534079
148Inositol phosphate metabolism_Homo sapiens_hsa005620.41684364
149Metabolic pathways_Homo sapiens_hsa011000.41567936
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40970383
151Renal cell carcinoma_Homo sapiens_hsa052110.40685489
152Wnt signaling pathway_Homo sapiens_hsa043100.40532571
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39796614
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39765705
155Arginine biosynthesis_Homo sapiens_hsa002200.38046919
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37926664
157p53 signaling pathway_Homo sapiens_hsa041150.37886635
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37562995
159SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34540742
160Colorectal cancer_Homo sapiens_hsa052100.34032865
161Circadian rhythm_Homo sapiens_hsa047100.33628034
162Tryptophan metabolism_Homo sapiens_hsa003800.32785305
163Ovarian steroidogenesis_Homo sapiens_hsa049130.32267392
164Central carbon metabolism in cancer_Homo sapiens_hsa052300.31788485
165Platelet activation_Homo sapiens_hsa046110.30770701
166Ether lipid metabolism_Homo sapiens_hsa005650.29518253
167Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29109563
168Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28848827
169beta-Alanine metabolism_Homo sapiens_hsa004100.28817307
170Melanoma_Homo sapiens_hsa052180.28808568
171Fatty acid elongation_Homo sapiens_hsa000620.28624752

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