SYT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.03425004
2synaptic vesicle maturation (GO:0016188)5.75389976
3locomotory exploration behavior (GO:0035641)5.57386964
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.29851401
5* positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24124985
6vocalization behavior (GO:0071625)5.18432316
7synaptic vesicle exocytosis (GO:0016079)5.12288040
8glutamate secretion (GO:0014047)5.01150596
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90473695
10regulation of synaptic vesicle exocytosis (GO:2000300)4.90007301
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.74956881
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.60302839
13regulation of glutamate receptor signaling pathway (GO:1900449)4.59260576
14neuronal action potential propagation (GO:0019227)4.55670521
15regulation of synaptic vesicle transport (GO:1902803)4.35858965
16protein localization to synapse (GO:0035418)4.30397032
17neuron cell-cell adhesion (GO:0007158)4.30037912
18exploration behavior (GO:0035640)4.26197729
19neurotransmitter secretion (GO:0007269)4.20820181
20regulation of neuronal synaptic plasticity (GO:0048168)4.19528186
21layer formation in cerebral cortex (GO:0021819)4.15551456
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15138492
23synaptic transmission, glutamatergic (GO:0035249)4.13259469
24glutamate receptor signaling pathway (GO:0007215)4.09896999
25dendritic spine morphogenesis (GO:0060997)3.98850648
26regulation of synapse structural plasticity (GO:0051823)3.92982355
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88178412
28cellular potassium ion homeostasis (GO:0030007)3.84124340
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81032058
30neuron-neuron synaptic transmission (GO:0007270)3.79389322
31long-term memory (GO:0007616)3.76591577
32gamma-aminobutyric acid transport (GO:0015812)3.75098659
33proline transport (GO:0015824)3.72594476
34activation of protein kinase A activity (GO:0034199)3.66249469
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66229871
36positive regulation of membrane potential (GO:0045838)3.62603406
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.59370857
38neurotransmitter-gated ion channel clustering (GO:0072578)3.52122432
39cerebellar Purkinje cell differentiation (GO:0021702)3.50531394
40regulation of postsynaptic membrane potential (GO:0060078)3.50276892
41sodium ion export (GO:0071436)3.50123103
42potassium ion homeostasis (GO:0055075)3.48592063
43neuron recognition (GO:0008038)3.45192767
44positive regulation of synapse maturation (GO:0090129)3.44074676
45neurotransmitter transport (GO:0006836)3.42843754
46regulation of synapse maturation (GO:0090128)3.41665962
47negative regulation of dendrite morphogenesis (GO:0050774)3.40514498
48transmission of nerve impulse (GO:0019226)3.38967917
49regulation of synaptic plasticity (GO:0048167)3.38579443
50L-amino acid import (GO:0043092)3.38064535
51regulation of neurotransmitter secretion (GO:0046928)3.36651548
52membrane depolarization during action potential (GO:0086010)3.35046474
53regulation of dendritic spine morphogenesis (GO:0061001)3.33044386
54cell communication by electrical coupling (GO:0010644)3.32918861
55chemosensory behavior (GO:0007635)3.32160349
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32004752
57neuromuscular process controlling balance (GO:0050885)3.31407529
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.30122530
59detection of calcium ion (GO:0005513)3.29660886
60synaptic vesicle endocytosis (GO:0048488)3.29232368
61regulation of vesicle fusion (GO:0031338)3.27764586
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27436605
63cytoskeletal anchoring at plasma membrane (GO:0007016)3.25962132
64innervation (GO:0060384)3.22101024
65cellular sodium ion homeostasis (GO:0006883)3.19746345
66axonal fasciculation (GO:0007413)3.19703954
67amino acid import (GO:0043090)3.18439613
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18392730
69dendrite morphogenesis (GO:0048813)3.16582127
70membrane depolarization (GO:0051899)3.14981202
71regulation of neurotransmitter levels (GO:0001505)3.13902427
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.11314287
73long-term synaptic potentiation (GO:0060291)3.10717953
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10227888
75neuromuscular process controlling posture (GO:0050884)3.09963351
76auditory behavior (GO:0031223)3.09523294
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07419408
78regulation of ARF protein signal transduction (GO:0032012)3.07150698
79regulation of neurotransmitter transport (GO:0051588)3.06715428
80regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05224477
81vesicle transport along microtubule (GO:0047496)3.04911075
82dendritic spine organization (GO:0097061)3.04170412
83glycine transport (GO:0015816)3.03461055
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03230619
85postsynaptic membrane organization (GO:0001941)3.02615483
86negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02017950
87neuronal ion channel clustering (GO:0045161)3.01888808
88cell communication involved in cardiac conduction (GO:0086065)3.00638750
89central nervous system myelination (GO:0022010)3.00187798
90axon ensheathment in central nervous system (GO:0032291)3.00187798
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98941899
92positive regulation of neurotransmitter secretion (GO:0001956)2.97182882
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96591721
94membrane hyperpolarization (GO:0060081)2.96052517
95signal release (GO:0023061)2.93525324
96regulation of voltage-gated calcium channel activity (GO:1901385)2.93159946
97response to auditory stimulus (GO:0010996)2.89928254
98positive regulation of dendritic spine development (GO:0060999)2.89483727
99prepulse inhibition (GO:0060134)2.89456818
100mating behavior (GO:0007617)2.89062944
101synapse assembly (GO:0007416)2.88922685
102social behavior (GO:0035176)2.86469776
103intraspecies interaction between organisms (GO:0051703)2.86469776
104synaptic transmission (GO:0007268)2.86448374
105potassium ion import (GO:0010107)2.86425469
106positive regulation of neurotransmitter transport (GO:0051590)2.86139987
107cerebellar Purkinje cell layer development (GO:0021680)2.85864663
108cerebellar granule cell differentiation (GO:0021707)2.84619431
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84321900
110regulation of synaptic transmission (GO:0050804)2.83835083
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.83636879
112regulation of dendritic spine development (GO:0060998)2.82588128
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73984141
114cardiac conduction (GO:0061337)2.71659429
115neuromuscular synaptic transmission (GO:0007274)2.70161081
116* regulation of exocytosis (GO:0017157)2.68455176
117positive regulation of dendrite development (GO:1900006)2.68178521
118urinary tract smooth muscle contraction (GO:0014848)2.66646071
119cell differentiation in hindbrain (GO:0021533)2.66332522
120cell migration in hindbrain (GO:0021535)2.64592186
121* regulation of calcium ion-dependent exocytosis (GO:0017158)2.60680405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.18692122
2GBX2_23144817_ChIP-Seq_PC3_Human3.22380940
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06329725
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99820579
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97751934
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.77543367
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70076431
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70076431
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62826986
10DROSHA_22980978_ChIP-Seq_HELA_Human2.61458266
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.54798295
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52497011
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52408520
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51456689
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46948660
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.45242358
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41991337
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41990974
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25070792
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.24309807
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23670138
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.20956427
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.18980733
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.08429574
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06846122
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94141700
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91920473
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87558590
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84282202
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83452010
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76020004
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62315735
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60744456
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54305014
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.54300859
36AR_21572438_ChIP-Seq_LNCaP_Human1.52200488
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48325204
38ZNF274_21170338_ChIP-Seq_K562_Hela1.48090268
39TAF15_26573619_Chip-Seq_HEK293_Human1.40358467
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39011941
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.37947607
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33301571
43* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32665601
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.30524236
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29237413
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29130397
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.28764527
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25082541
49* LXR_22292898_ChIP-Seq_THP-1_Human1.25019509
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24672853
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24006063
52STAT3_23295773_ChIP-Seq_U87_Human1.23741348
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23076104
54* AR_19668381_ChIP-Seq_PC3_Human1.22320026
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.21733386
56P300_19829295_ChIP-Seq_ESCs_Human1.20557942
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19902670
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19738871
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19581033
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18951970
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.18373009
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17824051
63* KDM2B_26808549_Chip-Seq_K562_Human1.17236256
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15532918
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14262767
66AR_25329375_ChIP-Seq_VCAP_Human1.14170263
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13825865
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12217304
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12138673
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11727325
71CREB1_26743006_Chip-Seq_LNCaP_Human1.11613777
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.11520480
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.10846930
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.10504607
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09959019
76IGF1R_20145208_ChIP-Seq_DFB_Human1.09818650
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07966032
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07643737
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06278653
80TCF4_23295773_ChIP-Seq_U87_Human1.06176947
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.05507043
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05062159
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.03967704
84AHR_22903824_ChIP-Seq_MCF-7_Human1.03722016
85* SMC4_20622854_ChIP-Seq_HELA_Human1.03008068
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02832727
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00585732
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00156883
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98611775
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97940563
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97900048
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97621646
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.97480171
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97286792
95ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97050971
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97025712
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96784904
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96453917
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.95638985
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.95270895
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94896597
102RNF2_27304074_Chip-Seq_NSC_Mouse0.94702168
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94673491
104RUNX2_22187159_ChIP-Seq_PCA_Human0.93925639
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93920757
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93849934
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.91733714
108* RACK7_27058665_Chip-Seq_MCF-7_Human0.91326667
109* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90771262
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90582258
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90186503
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.89963950
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87724363
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.87534001
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87293280
116* TET1_21490601_ChIP-Seq_MESCs_Mouse0.87119655
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85859957
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85859957
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85231560
120* CTCF_27219007_Chip-Seq_Bcells_Human0.83940522
121* PRDM14_20953172_ChIP-Seq_ESCs_Human0.83790638
122* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83655779
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83639889
124* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83091833
125TP53_16413492_ChIP-PET_HCT116_Human0.82792208
126BCAT_22108803_ChIP-Seq_LS180_Human0.82740080
127RXR_22158963_ChIP-Seq_LIVER_Mouse0.82324882
128OCT4_19829295_ChIP-Seq_ESCs_Human0.81003366
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80715694
130NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80485081
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79711174
132DPY_21335234_ChIP-Seq_ESCs_Mouse0.73922219
133* KLF4_19829295_ChIP-Seq_ESCs_Human0.70745792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.43122579
2MP0003880_abnormal_central_pattern4.49551674
3MP0003635_abnormal_synaptic_transmissio4.07226313
4MP0004270_analgesia3.85620052
5MP0009745_abnormal_behavioral_response3.23113866
6MP0002063_abnormal_learning/memory/cond3.17087203
7MP0002064_seizures3.00545053
8MP0009046_muscle_twitch2.99702431
9MP0001968_abnormal_touch/_nociception2.94642108
10MP0002734_abnormal_mechanical_nocicepti2.75816289
11MP0002572_abnormal_emotion/affect_behav2.67987699
12MP0005423_abnormal_somatic_nervous2.64997258
13MP0002272_abnormal_nervous_system2.59767749
14MP0003123_paternal_imprinting2.47388063
15MP0001486_abnormal_startle_reflex2.40542774
16MP0002909_abnormal_adrenal_gland2.36100301
17MP0009780_abnormal_chondrocyte_physiolo2.33043645
18MP0002735_abnormal_chemical_nociception2.32863865
19MP0002822_catalepsy2.26134162
20MP0002736_abnormal_nociception_after2.24073867
21MP0001501_abnormal_sleep_pattern2.22403459
22MP0002733_abnormal_thermal_nociception2.18422323
23MP0001440_abnormal_grooming_behavior2.08010419
24MP0001970_abnormal_pain_threshold2.07087863
25MP0002067_abnormal_sensory_capabilities1.96668017
26MP0008569_lethality_at_weaning1.94424869
27MP0002184_abnormal_innervation1.86899017
28MP0004858_abnormal_nervous_system1.79621610
29MP0002557_abnormal_social/conspecific_i1.74341953
30MP0004811_abnormal_neuron_physiology1.71573045
31MP0001984_abnormal_olfaction1.69333980
32MP0003329_amyloid_beta_deposits1.67884866
33MP0000778_abnormal_nervous_system1.64536672
34MP0003879_abnormal_hair_cell1.63444204
35MP0004924_abnormal_behavior1.63032336
36MP0005386_behavior/neurological_phenoty1.63032336
37MP0000955_abnormal_spinal_cord1.58892290
38MP0005646_abnormal_pituitary_gland1.56405785
39MP0003283_abnormal_digestive_organ1.54906303
40MP0006276_abnormal_autonomic_nervous1.54833543
41MP0005645_abnormal_hypothalamus_physiol1.44188428
42MP0004145_abnormal_muscle_electrophysio1.42248620
43MP0002882_abnormal_neuron_morphology1.39340406
44* MP0002066_abnormal_motor_capabilities/c1.37673672
45MP0003787_abnormal_imprinting1.37654748
46MP0000566_synostosis1.33732714
47MP0003633_abnormal_nervous_system1.33388086
48MP0004885_abnormal_endolymph1.31042279
49MP0010386_abnormal_urinary_bladder1.23061865
50MP0002837_dystrophic_cardiac_calcinosis1.22361848
51MP0001502_abnormal_circadian_rhythm1.21740442
52MP0000013_abnormal_adipose_tissue1.20692942
53MP0002139_abnormal_hepatobiliary_system1.13891297
54MP0003122_maternal_imprinting1.13807584
55MP0004043_abnormal_pH_regulation1.13377239
56MP0003195_calcinosis1.12814837
57MP0003631_nervous_system_phenotype1.09328980
58MP0005409_darkened_coat_color1.08548487
59MP0000751_myopathy1.07739612
60MP0008961_abnormal_basal_metabolism1.07602820
61MP0002152_abnormal_brain_morphology1.05353728
62MP0001188_hyperpigmentation1.02539201
63MP0004142_abnormal_muscle_tone1.01758585
64MP0002229_neurodegeneration0.99179752
65MP0001529_abnormal_vocalization0.99083172
66MP0001905_abnormal_dopamine_level0.98469022
67MP0004085_abnormal_heartbeat0.96465094
68MP0002069_abnormal_eating/drinking_beha0.96013719
69MP0003868_abnormal_feces_composition0.95960717
70MP0005535_abnormal_body_temperature0.93619777
71MP0005365_abnormal_bile_salt0.93066893
72MP0010329_abnormal_lipoprotein_level0.88931675
73MP0004742_abnormal_vestibular_system0.87770087
74MP0000569_abnormal_digit_pigmentation0.86826342
75MP0004215_abnormal_myocardial_fiber0.86318595
76MP0001666_abnormal_nutrient_absorption0.85730312
77MP0002638_abnormal_pupillary_reflex0.85113580
78MP0000631_abnormal_neuroendocrine_gland0.82777157
79MP0000462_abnormal_digestive_system0.82723163
80MP0005551_abnormal_eye_electrophysiolog0.81932091
81MP0003634_abnormal_glial_cell0.81901166
82MP0008872_abnormal_physiological_respon0.80164504
83MP0008874_decreased_physiological_sensi0.80089400
84MP0001485_abnormal_pinna_reflex0.78872111
85MP0005499_abnormal_olfactory_system0.78576912
86MP0005394_taste/olfaction_phenotype0.78576912
87MP0005085_abnormal_gallbladder_physiolo0.78446782
88MP0003121_genomic_imprinting0.77731135
89MP0001348_abnormal_lacrimal_gland0.77462463
90MP0003632_abnormal_nervous_system0.76865920
91MP0003075_altered_response_to0.75168185
92MP0002234_abnormal_pharynx_morphology0.75100107
93MP0002078_abnormal_glucose_homeostasis0.75088178
94MP0001963_abnormal_hearing_physiology0.74031123
95MP0000579_abnormal_nail_morphology0.73601250
96MP0003137_abnormal_impulse_conducting0.72986951
97MP0001177_atelectasis0.72840838
98MP0005187_abnormal_penis_morphology0.72646531
99MP0002693_abnormal_pancreas_physiology0.72381414
100MP0005448_abnormal_energy_balance0.70808064
101MP0001346_abnormal_lacrimal_gland0.70515726
102MP0002752_abnormal_somatic_nervous0.70392649
103MP0004484_altered_response_of0.69643583
104MP0003690_abnormal_glial_cell0.68977874
105MP0006072_abnormal_retinal_apoptosis0.68068557
106MP0001664_abnormal_digestion0.67660747
107MP0002876_abnormal_thyroid_physiology0.67109234
108MP0000920_abnormal_myelination0.66886183
109MP0001299_abnormal_eye_distance/0.65484937
110MP0001944_abnormal_pancreas_morphology0.63102417
111MP0000604_amyloidosis0.62477780
112MP0003172_abnormal_lysosome_physiology0.61165235
113MP0003953_abnormal_hormone_level0.60746618
114MP0002090_abnormal_vision0.60249794
115MP0002089_abnormal_postnatal_growth/wei0.60052842
116MP0010234_abnormal_vibrissa_follicle0.59800329
117MP0001765_abnormal_ion_homeostasis0.59248210
118MP0008877_abnormal_DNA_methylation0.59172230
119MP0002118_abnormal_lipid_homeostasis0.58598114
120MP0005167_abnormal_blood-brain_barrier0.57187560
121MP0004019_abnormal_vitamin_homeostasis0.56875543
122MP0000639_abnormal_adrenal_gland0.56754138
123MP0003183_abnormal_peptide_metabolism0.56075722

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.15404850
2Myokymia (HP:0002411)6.36920899
3Visual hallucinations (HP:0002367)5.56247868
4Focal seizures (HP:0007359)5.56233063
5Atonic seizures (HP:0010819)4.50116586
6Progressive cerebellar ataxia (HP:0002073)4.49244766
7Epileptic encephalopathy (HP:0200134)4.44718768
8Febrile seizures (HP:0002373)4.23955050
9Action tremor (HP:0002345)4.23080606
10Absence seizures (HP:0002121)4.03688191
11Generalized tonic-clonic seizures (HP:0002069)3.80175435
12Dialeptic seizures (HP:0011146)3.68303149
13Supranuclear gaze palsy (HP:0000605)3.60676727
14Gaze-evoked nystagmus (HP:0000640)3.43406029
15Broad-based gait (HP:0002136)3.37979433
16Papilledema (HP:0001085)3.36536852
17Depression (HP:0000716)3.29277926
18Poor eye contact (HP:0000817)3.29026892
19Akinesia (HP:0002304)3.21079661
20Hypoglycemic seizures (HP:0002173)3.20565188
21Ankle clonus (HP:0011448)3.19479337
22Dysdiadochokinesis (HP:0002075)3.06463601
23Anxiety (HP:0000739)3.06206690
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.05648806
25Dysmetria (HP:0001310)3.05179057
26Impaired vibration sensation in the lower limbs (HP:0002166)3.02219034
27Truncal ataxia (HP:0002078)3.02164556
28Amblyopia (HP:0000646)3.00167949
29Hyperinsulinemic hypoglycemia (HP:0000825)2.97526087
30Impaired smooth pursuit (HP:0007772)2.95848122
31Abnormal social behavior (HP:0012433)2.95540553
32Impaired social interactions (HP:0000735)2.95540553
33Genetic anticipation (HP:0003743)2.89690497
34Agitation (HP:0000713)2.84013929
35Ventricular fibrillation (HP:0001663)2.81653938
36Urinary bladder sphincter dysfunction (HP:0002839)2.80929512
37Hemiparesis (HP:0001269)2.75921326
38Epileptiform EEG discharges (HP:0011182)2.74941612
39Abnormality of aromatic amino acid family metabolism (HP:0004338)2.71902007
40Abnormality of the lower motor neuron (HP:0002366)2.68575964
41Hyperventilation (HP:0002883)2.68499591
42EEG with generalized epileptiform discharges (HP:0011198)2.67385413
43Postural instability (HP:0002172)2.65989868
44Sleep apnea (HP:0010535)2.57892036
45Hypsarrhythmia (HP:0002521)2.56048912
46Abnormal eating behavior (HP:0100738)2.55413287
47Drooling (HP:0002307)2.55397510
48Excessive salivation (HP:0003781)2.55397510
49Mutism (HP:0002300)2.55244168
50Hypoglycemic coma (HP:0001325)2.54818469
51Abnormality of ocular smooth pursuit (HP:0000617)2.53563359
52Increased circulating renin level (HP:0000848)2.50402706
53Cerebral inclusion bodies (HP:0100314)2.49086102
54Hemiplegia (HP:0002301)2.48003443
55Neurofibrillary tangles (HP:0002185)2.47785589
56Diplopia (HP:0000651)2.47231692
57Abnormality of binocular vision (HP:0011514)2.47231692
58Pheochromocytoma (HP:0002666)2.46251585
59Intention tremor (HP:0002080)2.44659397
60Spastic gait (HP:0002064)2.42198669
61Scanning speech (HP:0002168)2.41197193
62Bundle branch block (HP:0011710)2.40775977
63Bronchomalacia (HP:0002780)2.39583031
64Dysmetric saccades (HP:0000641)2.36086706
65Tetraplegia (HP:0002445)2.34792114
66Megalencephaly (HP:0001355)2.31667769
67Stereotypic behavior (HP:0000733)2.31498569
68Bradykinesia (HP:0002067)2.28745900
69Urinary urgency (HP:0000012)2.27665519
70Torticollis (HP:0000473)2.27069029
71Limb dystonia (HP:0002451)2.26897599
72Deep venous thrombosis (HP:0002625)2.25480763
73Termporal pattern (HP:0011008)2.24043780
74Insidious onset (HP:0003587)2.24043780
75Cerebral hypomyelination (HP:0006808)2.20730377
76Absent speech (HP:0001344)2.18060845
77Progressive inability to walk (HP:0002505)2.18042098
78Focal dystonia (HP:0004373)2.16429076
79Insomnia (HP:0100785)2.13191856
80Status epilepticus (HP:0002133)2.10491241
81Ketoacidosis (HP:0001993)2.08801956
82Abnormality of the corticospinal tract (HP:0002492)2.08348230
83Hyperthyroidism (HP:0000836)2.05555727
84Neuroendocrine neoplasm (HP:0100634)2.03541722
85Rigidity (HP:0002063)2.01824416
86Abnormal EKG (HP:0003115)2.01300145
87Insulin-resistant diabetes mellitus (HP:0000831)2.01138342
88Impaired vibratory sensation (HP:0002495)2.01057218
89Postural tremor (HP:0002174)1.99868356
90Gait ataxia (HP:0002066)1.99580318
91Prolonged partial thromboplastin time (HP:0003645)1.97929334
92Neuronal loss in central nervous system (HP:0002529)1.97034555
93Hyperparathyroidism (HP:0000843)1.96425678
94Lower limb muscle weakness (HP:0007340)1.95798052
95Prolonged QT interval (HP:0001657)1.94700541
96Heart block (HP:0012722)1.94159766
97Pointed chin (HP:0000307)1.93434095
98Abnormality of calcium-phosphate metabolism (HP:0100530)1.92248731
99Hyperglycemia (HP:0003074)1.92161248
100Amyotrophic lateral sclerosis (HP:0007354)1.91834701
101Annular pancreas (HP:0001734)1.91707067
102Syncope (HP:0001279)1.90942504
103Diminished movement (HP:0002374)1.90816875
104Psychosis (HP:0000709)1.90239486
105Late onset (HP:0003584)1.90104177
106Obstructive sleep apnea (HP:0002870)1.87853036
107Fetal akinesia sequence (HP:0001989)1.87699965
108Macroorchidism (HP:0000053)1.86869471
109Craniofacial dystonia (HP:0012179)1.85542191
110Delusions (HP:0000746)1.83926173
111Generalized myoclonic seizures (HP:0002123)1.83815714
112Morphological abnormality of the pyramidal tract (HP:0002062)1.83778129
113Symptomatic seizures (HP:0011145)1.83140968
114Enlarged penis (HP:0000040)1.83009905
115Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82493971
116Clonus (HP:0002169)1.82235967
117Rapidly progressive (HP:0003678)1.81458020
118Hypoventilation (HP:0002791)1.81423187
119Apathy (HP:0000741)1.81054123
120Hypercortisolism (HP:0001578)1.80816377
121Failure to thrive in infancy (HP:0001531)1.80433663
122Abnormal atrioventricular conduction (HP:0005150)1.79822647
123Decreased circulating renin level (HP:0003351)1.79476263
124Blue irides (HP:0000635)1.79008326
125Lower limb asymmetry (HP:0100559)1.78538831
126Hyperphosphatemia (HP:0002905)1.76090701
127Incomplete penetrance (HP:0003829)1.74643223
128Abnormality of salivation (HP:0100755)1.74177720
129Spastic tetraparesis (HP:0001285)1.73858161
130Abnormality of saccadic eye movements (HP:0000570)1.73132727
131Polyphagia (HP:0002591)1.70919810
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70457171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.69600439
2EPHA43.87426188
3MAP3K93.84077953
4MARK12.88472792
5MAP3K42.86648432
6DAPK22.63367620
7PRKD32.58520333
8MINK12.49572768
9MAP2K72.29335044
10PAK62.24632132
11KSR22.20739916
12RIPK42.03982699
13NTRK12.03277195
14CAMKK11.95791790
15NTRK21.91660424
16MAP2K41.78068283
17MAP3K21.76745294
18TRIB31.55957503
19GRK51.55752599
20CDK51.55571616
21SIK21.48637312
22MAP3K121.47055517
23DAPK11.45406954
24CAMKK21.45227011
25UHMK11.43513027
26STK381.41617586
27PNCK1.40870144
28TNIK1.39304958
29KSR11.35579492
30MAPK131.32948805
31CASK1.28899318
32PRKCG1.19139536
33PHKG11.18952406
34PHKG21.18952406
35PLK21.18779348
36PRPF4B1.17679448
37SIK11.16802576
38ARAF1.14178297
39FGFR21.13849316
40TESK11.09191335
41FES1.04654312
42TYRO31.03346180
43PRKCH1.03317067
44CAMK1D1.02527075
45RET1.02327451
46AKT31.00341201
47CAMK2A0.99690564
48CDK190.99124394
49STK110.96840930
50CAMK10.94366406
51PAK30.93877145
52MAP3K10.92737085
53CAMK2B0.92661727
54INSRR0.90167896
55MAP2K60.89246534
56TAOK10.88787887
57SGK2230.86691296
58SGK4940.86691296
59CDC42BPA0.86395389
60MAP3K130.83216005
61ALK0.82686584
62MARK20.81415344
63WNK10.79572667
64CDK150.77120196
65LMTK20.77084041
66CDK180.76809043
67PTK2B0.76721130
68PINK10.76373170
69RIPK10.75918601
70CDK140.75407565
71BMPR20.75366460
72SGK20.73349457
73DYRK1A0.71127254
74LATS20.70307863
75SGK10.70121744
76SGK30.68016273
77CDK11A0.66360354
78CSNK1G20.66328677
79CAMK2D0.65715617
80EEF2K0.65642497
81PDK10.65064765
82CAMK1G0.65058927
83EPHA20.63802982
84PDPK10.62630356
85ERBB20.60599232
86RAF10.58420528
87DAPK30.57205996
88MAPK120.57190385
89PKN20.56263706
90FER0.56091792
91ICK0.54794501
92SCYL20.54721902
93PRKCE0.54418132
94OXSR10.53983095
95WNK40.53290385
96HIPK20.52857622
97PTK20.52611202
98CAMK40.51902493
99PRKAA10.51860475
100RPS6KA30.51838021
101MAP3K70.50805253
102WNK30.49387707
103NME10.48351536
104FRK0.47178043
105CAMK2G0.46656955
106PRKCZ0.45928279
107PRKG20.45455586
108FYN0.44483479
109LIMK10.43867000
110NEK60.43397634
111MAPK100.43175963
112TNK20.41394059
113MAP3K110.40935173
114PRKD20.40540763
115IRAK20.40394585
116DMPK0.40004345
117MAPK80.39724494
118RPS6KA20.39212254
119MAP2K10.38705593
120PDGFRA0.35426577
121BRSK10.33070379
122PRKCB0.32618944

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39909799
2Synaptic vesicle cycle_Homo sapiens_hsa047213.03104037
3Long-term potentiation_Homo sapiens_hsa047202.71337706
4Circadian entrainment_Homo sapiens_hsa047132.66705578
5Olfactory transduction_Homo sapiens_hsa047402.64216900
6Glutamatergic synapse_Homo sapiens_hsa047242.57770342
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56839832
8GABAergic synapse_Homo sapiens_hsa047272.52893747
9Amphetamine addiction_Homo sapiens_hsa050312.48607404
10Insulin secretion_Homo sapiens_hsa049112.43483071
11Morphine addiction_Homo sapiens_hsa050322.34877041
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30721422
13Dopaminergic synapse_Homo sapiens_hsa047282.13468300
14Salivary secretion_Homo sapiens_hsa049702.11174109
15Taste transduction_Homo sapiens_hsa047421.97136389
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95318383
17Cholinergic synapse_Homo sapiens_hsa047251.91245898
18Gastric acid secretion_Homo sapiens_hsa049711.88928305
19Vitamin B6 metabolism_Homo sapiens_hsa007501.82258132
20Long-term depression_Homo sapiens_hsa047301.71702028
21Cocaine addiction_Homo sapiens_hsa050301.70894929
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69975601
23Type II diabetes mellitus_Homo sapiens_hsa049301.65433305
24Renin secretion_Homo sapiens_hsa049241.62201946
25Serotonergic synapse_Homo sapiens_hsa047261.58723047
26Oxytocin signaling pathway_Homo sapiens_hsa049211.58472816
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54877672
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54231245
29Calcium signaling pathway_Homo sapiens_hsa040201.53418934
30GnRH signaling pathway_Homo sapiens_hsa049121.48377070
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44729948
32Arginine biosynthesis_Homo sapiens_hsa002201.32167562
33cAMP signaling pathway_Homo sapiens_hsa040241.29979416
34Gap junction_Homo sapiens_hsa045401.29789821
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26500136
36Estrogen signaling pathway_Homo sapiens_hsa049151.25656663
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23422696
38Collecting duct acid secretion_Homo sapiens_hsa049661.22227623
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17215580
40Pancreatic secretion_Homo sapiens_hsa049721.15234851
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13194690
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13116332
43Histidine metabolism_Homo sapiens_hsa003401.12096061
44Glioma_Homo sapiens_hsa052141.06804714
45Melanogenesis_Homo sapiens_hsa049161.05138197
46Butanoate metabolism_Homo sapiens_hsa006501.02361538
47Cardiac muscle contraction_Homo sapiens_hsa042601.01991257
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.99428047
49Dorso-ventral axis formation_Homo sapiens_hsa043200.97426233
50Vibrio cholerae infection_Homo sapiens_hsa051100.96825578
51Thyroid hormone synthesis_Homo sapiens_hsa049180.95756788
52Phenylalanine metabolism_Homo sapiens_hsa003600.95425581
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95256081
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94936722
55Axon guidance_Homo sapiens_hsa043600.94550802
56ErbB signaling pathway_Homo sapiens_hsa040120.93268782
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90842421
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89793352
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.83643652
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.83266035
61Nitrogen metabolism_Homo sapiens_hsa009100.79858867
62beta-Alanine metabolism_Homo sapiens_hsa004100.79671189
63Dilated cardiomyopathy_Homo sapiens_hsa054140.78897077
64Oocyte meiosis_Homo sapiens_hsa041140.78817063
65Arginine and proline metabolism_Homo sapiens_hsa003300.77584935
66Type I diabetes mellitus_Homo sapiens_hsa049400.77260490
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76831458
68Glucagon signaling pathway_Homo sapiens_hsa049220.72141653
69Phototransduction_Homo sapiens_hsa047440.71615614
70Fatty acid biosynthesis_Homo sapiens_hsa000610.68579769
71ABC transporters_Homo sapiens_hsa020100.68363233
72Choline metabolism in cancer_Homo sapiens_hsa052310.68181102
73MAPK signaling pathway_Homo sapiens_hsa040100.66545833
74AMPK signaling pathway_Homo sapiens_hsa041520.65133713
75VEGF signaling pathway_Homo sapiens_hsa043700.64900129
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64216791
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.63979587
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.63965246
79mTOR signaling pathway_Homo sapiens_hsa041500.62081876
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59448399
81Inositol phosphate metabolism_Homo sapiens_hsa005620.58466712
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57090900
83Circadian rhythm_Homo sapiens_hsa047100.56428311
84Ras signaling pathway_Homo sapiens_hsa040140.53483089
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51199610
86Rap1 signaling pathway_Homo sapiens_hsa040150.49916394
87Bile secretion_Homo sapiens_hsa049760.49502478
88Complement and coagulation cascades_Homo sapiens_hsa046100.48927073
89Insulin signaling pathway_Homo sapiens_hsa049100.48580440
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.48522838
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48306511
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46937008
93Alcoholism_Homo sapiens_hsa050340.46654525
94Tight junction_Homo sapiens_hsa045300.46009931
95Ovarian steroidogenesis_Homo sapiens_hsa049130.45552872
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44805833
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44575671
98Prion diseases_Homo sapiens_hsa050200.44496410
99Endocytosis_Homo sapiens_hsa041440.44298000
100Endometrial cancer_Homo sapiens_hsa052130.44276096
101Tyrosine metabolism_Homo sapiens_hsa003500.43406611
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43200104
103PPAR signaling pathway_Homo sapiens_hsa033200.42050716
104Fatty acid degradation_Homo sapiens_hsa000710.40958868
105Wnt signaling pathway_Homo sapiens_hsa043100.40650893
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40245065
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39025840
108Renal cell carcinoma_Homo sapiens_hsa052110.38965894
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38575621
110Fatty acid metabolism_Homo sapiens_hsa012120.38408075
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38145766
112Alzheimers disease_Homo sapiens_hsa050100.37799057
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37392095
114Non-small cell lung cancer_Homo sapiens_hsa052230.37037498
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36173366
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35951095
117Prolactin signaling pathway_Homo sapiens_hsa049170.34648139
118Retinol metabolism_Homo sapiens_hsa008300.34642751
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33953563
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.33598795
121Tryptophan metabolism_Homo sapiens_hsa003800.33142380
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32683729
123Chemokine signaling pathway_Homo sapiens_hsa040620.30676045
124Insulin resistance_Homo sapiens_hsa049310.30615871
125African trypanosomiasis_Homo sapiens_hsa051430.29145629
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23016498
127Mineral absorption_Homo sapiens_hsa049780.22495024

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