SYT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of gastrointestinal epithelium (GO:0030277)9.63466895
2hemidesmosome assembly (GO:0031581)7.62650636
3epithelial structure maintenance (GO:0010669)7.40264504
4citrulline biosynthetic process (GO:0019240)6.37186218
5hypotonic response (GO:0006971)6.24607807
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.15551263
7one-carbon compound transport (GO:0019755)5.01186670
8establishment of skin barrier (GO:0061436)4.99388892
9regulation of water loss via skin (GO:0033561)4.93015799
10semaphorin-plexin signaling pathway (GO:0071526)4.84570405
11hair cycle (GO:0042633)4.76243670
12molting cycle (GO:0042303)4.76243670
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.72771710
14protein autoprocessing (GO:0016540)4.68971296
15regulation of ruffle assembly (GO:1900027)4.54319937
16regulation of phospholipase A2 activity (GO:0032429)4.54126317
17activation of Rac GTPase activity (GO:0032863)4.49741368
18extracellular fibril organization (GO:0043206)4.48641924
19glutathione derivative metabolic process (GO:1901685)4.45020131
20glutathione derivative biosynthetic process (GO:1901687)4.45020131
21citrulline metabolic process (GO:0000052)4.42634414
22multicellular organismal water homeostasis (GO:0050891)4.42387174
23peptidyl-tyrosine autophosphorylation (GO:0038083)4.37682160
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.34506306
25digestion (GO:0007586)4.32443225
26membrane budding (GO:0006900)4.30706284
27regulation of Cdc42 GTPase activity (GO:0043088)4.30691328
28neutrophil activation involved in immune response (GO:0002283)4.29450773
29endocrine hormone secretion (GO:0060986)4.26525813
30parturition (GO:0007567)4.24137687
31establishment of apical/basal cell polarity (GO:0035089)4.21601342
32O-glycan processing (GO:0016266)4.16753053
33negative regulation of keratinocyte proliferation (GO:0010839)4.06557031
34fibril organization (GO:0097435)4.04630444
35cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.02997337
36chondrocyte development (GO:0002063)4.01428946
37positive regulation of osteoblast proliferation (GO:0033690)4.00244032
38cell adhesion mediated by integrin (GO:0033627)3.92967425
39keratan sulfate catabolic process (GO:0042340)3.92518844
40keratinocyte proliferation (GO:0043616)3.85869778
41lung vasculature development (GO:0060426)3.81563110
42desmosome organization (GO:0002934)3.74946890
43digestive tract morphogenesis (GO:0048546)3.74637293
44digestive system process (GO:0022600)3.65610233
45protein retention in ER lumen (GO:0006621)3.65316931
46negative regulation of chondrocyte differentiation (GO:0032331)3.65224848
47peptidyl-proline hydroxylation (GO:0019511)3.64331882
48endothelial cell morphogenesis (GO:0001886)3.63276987
49endodermal cell differentiation (GO:0035987)3.62471963
50positive regulation of Cdc42 GTPase activity (GO:0043089)3.60652789
51nucleotide-sugar biosynthetic process (GO:0009226)3.57159124
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56074699
53peptidyl-arginine modification (GO:0018195)3.55678653
54water homeostasis (GO:0030104)3.54344683
55regulation of clathrin-mediated endocytosis (GO:2000369)3.52987034
56positive regulation of extracellular matrix organization (GO:1903055)3.51003608
57establishment of tissue polarity (GO:0007164)3.50042066
58establishment of planar polarity (GO:0001736)3.50042066
59apoptotic process involved in morphogenesis (GO:0060561)3.49990401
60cartilage condensation (GO:0001502)3.49654894
61cell aggregation (GO:0098743)3.49654894
62regulation of cholesterol biosynthetic process (GO:0045540)3.49527151
63establishment of monopolar cell polarity (GO:0061162)3.48603580
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.48603580
65regulation of proton transport (GO:0010155)3.46146676
66embryonic foregut morphogenesis (GO:0048617)3.43033666
67interferon-gamma secretion (GO:0072643)3.40240056
68mesodermal cell differentiation (GO:0048333)3.37544074
69behavioral response to ethanol (GO:0048149)3.36061981
70cell-substrate junction assembly (GO:0007044)3.35434408
71lipopolysaccharide metabolic process (GO:0008653)3.32193258
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31758805
73lung epithelium development (GO:0060428)3.29697454
74negative regulation of osteoblast proliferation (GO:0033689)3.27616713
75collagen fibril organization (GO:0030199)3.24754899
76notochord development (GO:0030903)3.23303378
77Rho protein signal transduction (GO:0007266)3.22678092
78Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.22321481
79wound healing, spreading of epidermal cells (GO:0035313)3.21807021
80cardiac right ventricle morphogenesis (GO:0003215)3.20930320
81negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.20596864
82positive regulation of histone deacetylation (GO:0031065)3.19790618
83negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.16589897
84keratinocyte development (GO:0003334)3.15970376
85behavioral response to pain (GO:0048266)3.15661046
86branching involved in mammary gland duct morphogenesis (GO:0060444)3.15472168
87keratinization (GO:0031424)3.14880819
88regulation of voltage-gated calcium channel activity (GO:1901385)3.12030275
89urogenital system development (GO:0001655)3.11008270
90cell-cell junction maintenance (GO:0045217)3.06715606
91morphogenesis of embryonic epithelium (GO:0016331)3.06712390
92regulation of establishment of planar polarity (GO:0090175)3.05570810
93ectoderm development (GO:0007398)3.04181030
94epidermis development (GO:0008544)3.03565594
95protein hydroxylation (GO:0018126)3.03407144
96hepatocyte apoptotic process (GO:0097284)3.01722935
97intermediate filament organization (GO:0045109)3.00237364
98cyclooxygenase pathway (GO:0019371)3.00142156
99positive regulation of p38MAPK cascade (GO:1900745)2.98559731
100dendritic spine morphogenesis (GO:0060997)2.97094000
101regulation of integrin-mediated signaling pathway (GO:2001044)2.96514143
102epithelial cell-cell adhesion (GO:0090136)2.95303183
103endothelial cell chemotaxis (GO:0035767)2.93755188
104intestinal epithelial cell development (GO:0060576)2.92672927
105embryonic camera-type eye development (GO:0031076)2.92489909
106skin morphogenesis (GO:0043589)2.92013146
107endosome organization (GO:0007032)2.91724511
108extracellular matrix disassembly (GO:0022617)2.91480250
109positive regulation of actin filament depolymerization (GO:0030836)2.91355575
110positive regulation of mast cell activation involved in immune response (GO:0033008)2.90395529
111positive regulation of mast cell degranulation (GO:0043306)2.90395529
112COPI coating of Golgi vesicle (GO:0048205)2.90024136
113Golgi transport vesicle coating (GO:0048200)2.90024136
114positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.89671898
115protein O-linked glycosylation (GO:0006493)2.88717987
116dendritic spine organization (GO:0097061)2.87230652
117negative regulation of cartilage development (GO:0061037)2.87076587
118regulation of apoptotic process involved in morphogenesis (GO:1902337)2.87024504
119extracellular matrix assembly (GO:0085029)2.84760312
120regulation of apoptotic cell clearance (GO:2000425)2.84701524
121membrane raft organization (GO:0031579)2.84632925
122asymmetric protein localization (GO:0008105)2.83853817
123UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83167383
124cell volume homeostasis (GO:0006884)2.82439482
125regulation of keratinocyte proliferation (GO:0010837)2.82028087
126regulation of hair follicle development (GO:0051797)2.81323003
1274-hydroxyproline metabolic process (GO:0019471)2.79486875
128cellular response to fluid shear stress (GO:0071498)2.78716926
129regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78462419
130ventricular cardiac muscle cell action potential (GO:0086005)2.78438008
131cell differentiation involved in embryonic placenta development (GO:0060706)2.77933439
132positive regulation of epidermis development (GO:0045684)2.77748591
133regulation of transforming growth factor beta1 production (GO:0032908)2.77040552
134epithelial cell fate commitment (GO:0072148)2.76314019
135activation of JUN kinase activity (GO:0007257)2.74609159
136sulfation (GO:0051923)2.73523188
1373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.73226823
138purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.73226823
139regulation of glucocorticoid secretion (GO:2000849)2.72486932
140positive regulation of leukocyte degranulation (GO:0043302)2.72040637
141atrioventricular valve morphogenesis (GO:0003181)2.71163723
142peptide cross-linking (GO:0018149)2.69596211
143cell junction assembly (GO:0034329)2.69488589
144regulation of cholesterol metabolic process (GO:0090181)2.69468413
145cell-substrate adherens junction assembly (GO:0007045)2.68918313
146focal adhesion assembly (GO:0048041)2.68918313
147glutathione biosynthetic process (GO:0006750)2.67567324
148negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.66601444
149L-serine transport (GO:0015825)2.66265090
150signal complex assembly (GO:0007172)2.66057732
151collagen metabolic process (GO:0032963)2.65873712
152adherens junction assembly (GO:0034333)2.65218462
153lung secretory cell differentiation (GO:0061140)2.64310372
154cytoskeletal anchoring at plasma membrane (GO:0007016)2.64199666
155multicellular organismal catabolic process (GO:0044243)2.62616008
156apoptotic cell clearance (GO:0043277)2.62413201
157epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62380688
158regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.61636709
159cell junction organization (GO:0034330)2.61562597
160phosphatidylserine metabolic process (GO:0006658)2.61431863
161multicellular organismal metabolic process (GO:0044236)2.59892708
162keratinocyte differentiation (GO:0030216)2.59442844
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.59065909
164neutrophil activation (GO:0042119)2.59022729
165response to iron ion (GO:0010039)2.57855345
166collagen catabolic process (GO:0030574)2.56556447
167nitric oxide biosynthetic process (GO:0006809)2.55556689
168regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.54686170
169chondrocyte proliferation (GO:0035988)2.54287031
170regulation of membrane protein ectodomain proteolysis (GO:0051043)2.52296035
171serine transport (GO:0032329)2.51946504
172renal system development (GO:0072001)2.51369400
173limb bud formation (GO:0060174)2.49806907
174regulation of metalloenzyme activity (GO:0048552)2.48341335
175regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46918089
176negative regulation of interleukin-8 production (GO:0032717)2.44422408
177cellular response to arsenic-containing substance (GO:0071243)2.44359514
178lung lobe morphogenesis (GO:0060463)2.43897447
179regulation of heart rate by cardiac conduction (GO:0086091)2.43774716
180multicellular organismal macromolecule metabolic process (GO:0044259)2.43743865
181cellular response to osmotic stress (GO:0071470)2.43166857
182regulation of plasminogen activation (GO:0010755)2.42510994
183positive regulation of protein localization to plasma membrane (GO:1903078)2.39711988
184positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.39173862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.30695911
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.34131665
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.55136904
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.24005159
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01704600
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.57292129
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.54630479
8ESR1_15608294_ChIP-ChIP_MCF-7_Human3.12290735
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.96391444
10* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.88664040
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.61658648
12SOX2_20726797_ChIP-Seq_SW620_Human2.60789444
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.50420925
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.50420925
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.37775237
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.27452096
17* GATA4_25053715_ChIP-Seq_YYC3_Human2.21922057
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15245671
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13281053
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96178596
21GATA6_25053715_ChIP-Seq_YYC3_Human1.88849408
22CJUN_26792858_Chip-Seq_BT549_Human1.88621227
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86828241
24KLF5_25053715_ChIP-Seq_YYC3_Human1.86001406
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85942253
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.85466821
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82736370
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.82294085
29CLOCK_20551151_ChIP-Seq_293T_Human1.81877250
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78793195
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77340907
32* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71161303
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71056301
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69604551
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67452448
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65686234
37RACK7_27058665_Chip-Seq_MCF-7_Human1.63884870
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61548235
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.60976404
40P68_20966046_ChIP-Seq_HELA_Human1.60296537
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.59758336
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59474695
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59474695
44TP63_22573176_ChIP-Seq_HFKS_Human1.59043090
45CTCF_27219007_Chip-Seq_Bcells_Human1.58524208
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58210266
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57921154
48KDM2B_26808549_Chip-Seq_K562_Human1.56992207
49JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53829055
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.53259422
51* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50841605
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50522163
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50448234
54SMC4_20622854_ChIP-Seq_HELA_Human1.50264955
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49358633
56ATF3_27146783_Chip-Seq_COLON_Human1.48945102
57* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47870138
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45718748
59* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44480508
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42313487
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40482140
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39259389
63* SA1_27219007_Chip-Seq_ERYTHROID_Human1.39181110
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.38767223
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37734219
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.36959625
67* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36845366
68* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32120100
69GATA3_24758297_ChIP-Seq_MCF-7_Human1.32085960
70KDM2B_26808549_Chip-Seq_DND41_Human1.31429754
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30413498
72CREB1_26743006_Chip-Seq_LNCaP_Human1.29075028
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28981304
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28806019
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.28738415
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.28472949
77VDR_21846776_ChIP-Seq_THP-1_Human1.28200210
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27156468
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23982240
80TCF7_22412390_ChIP-Seq_EML_Mouse1.23936884
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23020419
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.22911527
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22481772
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.22031340
85AHR_22903824_ChIP-Seq_MCF-7_Human1.18060109
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17382448
87TP53_22127205_ChIP-Seq_IMR90_Human1.17065731
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.16869554
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15137720
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15041282
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14812544
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13980164
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.13713031
94* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11484218
95GATA1_22025678_ChIP-Seq_K562_Human1.10974390
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10457318
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10371048
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10216479
99* LXR_22292898_ChIP-Seq_THP-1_Human1.09740609
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08281270
101EGR1_19032775_ChIP-ChIP_M12_Human1.08106432
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.07129846
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06817821
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06614535
105BCL6_27268052_Chip-Seq_Bcells_Human1.06118169
106* BCOR_27268052_Chip-Seq_Bcells_Human1.05383477
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03357413
108BRD4_25478319_ChIP-Seq_HGPS_Human1.02592998
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01654147
110RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01166604
111RXR_22158963_ChIP-Seq_LIVER_Mouse1.00605231
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99588536
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99558483
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99502032
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99433681
116JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99237065
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98338433
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96584827
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.96376401
120LXR_22158963_ChIP-Seq_LIVER_Mouse0.94122756
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93508840
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93418214
123VDR_24763502_ChIP-Seq_THP-1_Human0.93299689
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.93148751
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92512219
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92203943
127ZNF263_19887448_ChIP-Seq_K562_Human0.91972344
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.91864945
129SA1_27219007_Chip-Seq_Bcells_Human0.91800025
130* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90932321
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90181968
132VDR_24787735_ChIP-Seq_THP-1_Human0.89997473
133FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89661908
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89594249
135* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89547257
136ELF5_23300383_ChIP-Seq_T47D_Human0.88621571
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87993699
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.87967149
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.87967149
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87615742
141E2F1_20622854_ChIP-Seq_HELA_Human0.87012797
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86544002
143TP63_23658742_ChIP-Seq_EP156T_Human0.86511413
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85507787
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.83940751
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83034478
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82834417
148PHF8_20622854_ChIP-Seq_HELA_Human0.82122735
149FOXA2_19822575_ChIP-Seq_HepG2_Human0.81363708
150AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80904821
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80254984
152AR_21909140_ChIP-Seq_LNCAP_Human0.79447464
153ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76162029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.27593288
2MP0004381_abnormal_hair_follicle4.01647237
3MP0005367_renal/urinary_system_phenotyp3.89278676
4MP0000516_abnormal_urinary_system3.89278676
5MP0001873_stomach_inflammation3.74174149
6MP0001664_abnormal_digestion3.34233191
7MP0010386_abnormal_urinary_bladder3.03971570
8MP0005409_darkened_coat_color2.99705474
9MP0000470_abnormal_stomach_morphology2.63783307
10MP0010234_abnormal_vibrissa_follicle2.59313698
11MP0003806_abnormal_nucleotide_metabolis2.40347674
12MP0005275_abnormal_skin_tensile2.28402928
13MP0001542_abnormal_bone_strength2.25566732
14MP0003566_abnormal_cell_adhesion2.08605510
15MP0002282_abnormal_trachea_morphology2.05246183
16MP0008004_abnormal_stomach_pH10.9232389
17MP0009780_abnormal_chondrocyte_physiolo1.88923945
18MP0003705_abnormal_hypodermis_morpholog1.83110698
19MP0004264_abnormal_extraembryonic_tissu1.82857138
20MP0000537_abnormal_urethra_morphology1.77754509
21MP0003941_abnormal_skin_development1.76756026
22MP0004134_abnormal_chest_morphology1.74162810
23MP0006054_spinal_hemorrhage1.73359988
24MP0001663_abnormal_digestive_system1.57583332
25MP0005381_digestive/alimentary_phenotyp1.56922585
26MP0010030_abnormal_orbit_morphology1.56335262
27MP0002254_reproductive_system_inflammat1.55692712
28MP0009384_cardiac_valve_regurgitation1.53414221
29MP0002796_impaired_skin_barrier1.52264263
30MP0002060_abnormal_skin_morphology1.51991301
31MP0000762_abnormal_tongue_morphology1.51344707
32MP0002896_abnormal_bone_mineralization1.47395250
33MP0008438_abnormal_cutaneous_collagen1.44022974
34MP0000462_abnormal_digestive_system1.39488045
35MP0001849_ear_inflammation1.39193514
36MP0000538_abnormal_urinary_bladder1.38143258
37MP0005171_absent_coat_pigmentation1.38078133
38MP0002249_abnormal_larynx_morphology1.37870409
39MP0002933_joint_inflammation1.35689687
40MP0000163_abnormal_cartilage_morphology1.28992484
41MP0001216_abnormal_epidermal_layer1.28803333
42MP0010352_gastrointestinal_tract_polyps1.27235751
43MP0005023_abnormal_wound_healing1.27041253
44MP0001958_emphysema1.25471718
45MP0000678_abnormal_parathyroid_gland1.25339849
46MP0003453_abnormal_keratinocyte_physiol1.25010107
47MP0004272_abnormal_basement_membrane1.24657144
48MP0001533_abnormal_skeleton_physiology1.23655804
49MP0005083_abnormal_biliary_tract1.20212878
50MP0000534_abnormal_ureter_morphology1.19913334
51MP0004947_skin_inflammation1.15276933
52MP0000569_abnormal_digit_pigmentation1.11137609
53MP0000013_abnormal_adipose_tissue1.09937916
54MP0006138_congestive_heart_failure1.06152806
55MP0001666_abnormal_nutrient_absorption1.04575602
56MP0005075_abnormal_melanosome_morpholog1.04240502
57MP0002909_abnormal_adrenal_gland1.03371509
58MP0003045_fibrosis1.02934011
59MP0001756_abnormal_urination1.02674238
60MP0000477_abnormal_intestine_morphology1.00881609
61MP0002113_abnormal_skeleton_development1.00244080
62MP0004782_abnormal_surfactant_physiolog0.99509721
63MP0005058_abnormal_lysosome_morphology0.98447931
64MP0005360_urolithiasis0.98322099
65MP0003283_abnormal_digestive_organ0.97871476
66MP0002089_abnormal_postnatal_growth/wei0.97069831
67MP0000427_abnormal_hair_cycle0.97021588
68MP0005165_increased_susceptibility_to0.95936232
69MP0002234_abnormal_pharynx_morphology0.95567249
70MP0005670_abnormal_white_adipose0.95336528
71MP0010678_abnormal_skin_adnexa0.94389761
72MP0005503_abnormal_tendon_morphology0.92743330
73MP0003436_decreased_susceptibility_to0.91858775
74MP0000467_abnormal_esophagus_morphology0.91583235
75MP0003186_abnormal_redox_activity0.91504364
76MP0005501_abnormal_skin_physiology0.91368963
77MP0001299_abnormal_eye_distance/0.91154060
78MP0000751_myopathy0.90754916
79MP0002115_abnormal_skeleton_extremities0.90237613
80MP0003191_abnormal_cellular_cholesterol0.90073232
81MP0008875_abnormal_xenobiotic_pharmacok0.89802675
82MP0003795_abnormal_bone_structure0.89292115
83MP0000003_abnormal_adipose_tissue0.88950916
84MP0010155_abnormal_intestine_physiology0.88571069
85MP0009053_abnormal_anal_canal0.88174594
86MP0000367_abnormal_coat/_hair0.87408044
87MP0001340_abnormal_eyelid_morphology0.87099194
88MP0008789_abnormal_olfactory_epithelium0.85832861
89MP0005166_decreased_susceptibility_to0.85797406
90MP0005390_skeleton_phenotype0.85064774
91MP0003300_gastrointestinal_ulcer0.84774598
92MP0005330_cardiomyopathy0.83302403
93MP0002877_abnormal_melanocyte_morpholog0.83086843
94MP0004185_abnormal_adipocyte_glucose0.82816162
95MP0001243_abnormal_dermal_layer0.81840854
96MP0002998_abnormal_bone_remodeling0.80382184
97MP0001853_heart_inflammation0.80051498
98MP0000685_abnormal_immune_system0.78330244
99MP0003091_abnormal_cell_migration0.78215724
100MP0010771_integument_phenotype0.78085912
101MP0002098_abnormal_vibrissa_morphology0.77580535
102MP0004484_altered_response_of0.74917558
103MP0001765_abnormal_ion_homeostasis0.74532281
104MP0000343_altered_response_to0.73273601
105MP0000465_gastrointestinal_hemorrhage0.70923829
106MP0009643_abnormal_urine_homeostasis0.70338284
107MP0009250_abnormal_appendicular_skeleto0.70212172
108MP0009931_abnormal_skin_appearance0.69638676
109MP0003866_abnormal_defecation0.69481556
110MP0005076_abnormal_cell_differentiation0.69353935
111MP0001270_distended_abdomen0.68029796
112MP0003183_abnormal_peptide_metabolism0.67054857
113MP0003172_abnormal_lysosome_physiology0.66900734
114MP0009785_altered_susceptibility_to0.66769548
115MP0000579_abnormal_nail_morphology0.65320057
116MP0000858_altered_metastatic_potential0.64446594
117MP0003115_abnormal_respiratory_system0.62748885
118MP0003075_altered_response_to0.61173660
119MP0005464_abnormal_platelet_physiology0.60849194
120MP0004019_abnormal_vitamin_homeostasis0.59948738
121MP0005508_abnormal_skeleton_morphology0.59892755
122MP0000627_abnormal_mammary_gland0.59773697
123MP0004883_abnormal_blood_vessel0.59579317
124MP0002419_abnormal_innate_immunity0.59473767
125MP0003755_abnormal_palate_morphology0.58080522
126MP0005375_adipose_tissue_phenotype0.58066060
127MP0003119_abnormal_digestive_system0.57719402
128MP0008260_abnormal_autophagy0.57353360
129MP0001851_eye_inflammation0.57015908
130MP0001881_abnormal_mammary_gland0.56700516
131MP0000383_abnormal_hair_follicle0.55732639
132MP0001348_abnormal_lacrimal_gland0.55655606
133MP0002136_abnormal_kidney_physiology0.55568942
134MP0005499_abnormal_olfactory_system0.55523366
135MP0005394_taste/olfaction_phenotype0.55523366
136MP0000767_abnormal_smooth_muscle0.54734600
137MP0003448_altered_tumor_morphology0.54283525
138MP0000377_abnormal_hair_follicle0.53453562
139MP0005164_abnormal_response_to0.52862787
140MP0004858_abnormal_nervous_system0.52497642
141MP0000432_abnormal_head_morphology0.52199969
142MP0000733_abnormal_muscle_development0.50331510
143MP0002109_abnormal_limb_morphology0.50159537
144MP0002932_abnormal_joint_morphology0.49981792
145MP0005408_hypopigmentation0.49116238
146MP0000639_abnormal_adrenal_gland0.48790289
147MP0000647_abnormal_sebaceous_gland0.48246656
148MP0002111_abnormal_tail_morphology0.47683595
149MP0005666_abnormal_adipose_tissue0.47576021

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)6.65438027
2Epiphyseal dysplasia (HP:0002656)6.31300771
3Irregular epiphyses (HP:0010582)5.21770869
4Alopecia of scalp (HP:0002293)5.09203460
5Pili torti (HP:0003777)4.92496748
6Right ventricular cardiomyopathy (HP:0011663)4.83149923
7Thick nail (HP:0001805)4.77878859
8Flat acetabular roof (HP:0003180)4.76498347
9Vitreoretinal degeneration (HP:0000655)4.69396590
10Abnormality of nail color (HP:0100643)4.56838777
11Abnormal tarsal ossification (HP:0008369)4.51470785
12Cupped ribs (HP:0000887)4.45410201
13Plantar hyperkeratosis (HP:0007556)4.23973830
14Abnormal foot bone ossification (HP:0010675)4.23848289
15Onycholysis (HP:0001806)4.19478570
16Hypoplastic ischia (HP:0003175)4.04756691
17Pterygium (HP:0001059)3.95626236
18Atrophic scars (HP:0001075)3.91604428
19Obstructive sleep apnea (HP:0002870)3.75096555
20Aortic aneurysm (HP:0004942)3.73669677
21Abnormal hair laboratory examination (HP:0003328)3.68141556
22Lip pit (HP:0100267)3.64731088
23Milia (HP:0001056)3.61066387
24Ridged nail (HP:0001807)3.60367690
25Abnormality of the salivary glands (HP:0010286)3.60237362
26Hypotrichosis (HP:0001006)3.59723699
27Abnormality of the ischium (HP:0003174)3.46301274
28Cervical subluxation (HP:0003308)3.40126483
29Flat capital femoral epiphysis (HP:0003370)3.39391691
30Small epiphyses (HP:0010585)3.35106748
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.28803357
32Palmoplantar hyperkeratosis (HP:0000972)3.27336457
33Aortic dissection (HP:0002647)3.25411237
34Abnormality of the neuromuscular junction (HP:0003398)3.25149040
35Fatigable weakness (HP:0003473)3.25149040
36Neonatal short-limb short stature (HP:0008921)3.24351518
37Hydroxyprolinuria (HP:0003080)3.17049676
38Abnormality of proline metabolism (HP:0010907)3.17049676
39Absent frontal sinuses (HP:0002688)3.13873596
40Thin bony cortex (HP:0002753)3.08840551
41Palmar hyperkeratosis (HP:0010765)3.01567909
42Ankle contracture (HP:0006466)2.95054414
43Abnormal blistering of the skin (HP:0008066)2.93812795
44Genu varum (HP:0002970)2.89138493
45Distal upper limb amyotrophy (HP:0007149)2.85416610
46Upper limb amyotrophy (HP:0009129)2.85416610
47Natal tooth (HP:0000695)2.81690241
48Flattened epiphyses (HP:0003071)2.79176128
49Advanced eruption of teeth (HP:0006288)2.76890831
50Nasolacrimal duct obstruction (HP:0000579)2.76307526
51Abnormality of the 2nd finger (HP:0004100)2.76150521
52Malnutrition (HP:0004395)2.75895992
53Easy fatigability (HP:0003388)2.72634950
54Hypoplasia of dental enamel (HP:0006297)2.72347509
55Aplasia cutis congenita (HP:0001057)2.70485241
56Ulnar bowing (HP:0003031)2.69693129
57Osteoarthritis (HP:0002758)2.68387269
58Abnormal vertebral ossification (HP:0100569)2.67588644
59Radial bowing (HP:0002986)2.65810185
60Mildly elevated creatine phosphokinase (HP:0008180)2.65637479
61Broad face (HP:0000283)2.63079708
62Abnormality of carpal bone ossification (HP:0006257)2.62355975
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.60575565
64Hyperactive renin-angiotensin system (HP:0000841)2.56854946
65Popliteal pterygium (HP:0009756)2.56226075
66Metaphyseal cupping (HP:0003021)2.53846099
67Abnormal ossification of hand bones (HP:0005921)2.52419114
68Distal lower limb amyotrophy (HP:0008944)2.52280132
69Delayed epiphyseal ossification (HP:0002663)2.48987881
70Alacrima (HP:0000522)2.48430633
71Coxa vara (HP:0002812)2.44233247
72Barrel-shaped chest (HP:0001552)2.43175246
73Abnormality of the distal phalanges of the toes (HP:0010182)2.42052269
74Acanthosis nigricans (HP:0000956)2.40059138
75Abnormality of the odontoid process (HP:0003310)2.35935975
76Short femoral neck (HP:0100864)2.34157979
77Beaking of vertebral bodies (HP:0004568)2.33349136
78Platyspondyly (HP:0000926)2.31650882
79Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.29927286
80Vertebral hypoplasia (HP:0008417)2.29927286
81Shallow orbits (HP:0000586)2.27696324
82Abnormality of the proximal phalanges of the hand (HP:0009834)2.26703081
83Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.25492238
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.24646609
85Osteolytic defects of the hand bones (HP:0009699)2.24646609
86Diaphragmatic weakness (HP:0009113)2.24174095
87Hypoplasia of the odontoid process (HP:0003311)2.23945189
88Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.23334295
89Selective tooth agenesis (HP:0001592)2.23327098
90Protuberant abdomen (HP:0001538)2.22004160
91Glossoptosis (HP:0000162)2.21961602
92Gastrointestinal dysmotility (HP:0002579)2.18979473
93Abnormality of the frontal sinuses (HP:0002687)2.17133600
94Bulbar palsy (HP:0001283)2.17045086
95Sparse scalp hair (HP:0002209)2.16180881
96Lumbar hyperlordosis (HP:0002938)2.13962095
97Stridor (HP:0010307)2.12095748
98Dry hair (HP:0011359)2.11605845
99Hypoplastic labia majora (HP:0000059)2.10574879
100Stillbirth (HP:0003826)2.10253614
101Spinal cord compression (HP:0002176)2.09339703
102Focal segmental glomerulosclerosis (HP:0000097)2.09282445
103Follicular hyperkeratosis (HP:0007502)2.09065151
104Scapular winging (HP:0003691)2.08863263
105Mesomelia (HP:0003027)2.08651994
106Limited elbow extension (HP:0001377)2.07902615
107Erythema (HP:0010783)2.07751022
108Abdominal distention (HP:0003270)2.07404670
109Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.07137538
110Abnormality of femoral epiphyses (HP:0006499)2.07137538
111Abnormality of the calcaneus (HP:0008364)2.04717647
112Vertebral clefting (HP:0008428)2.04572628
113Hypoplasia of the iris (HP:0007676)2.03785551
114Exostoses (HP:0100777)2.03630233
115Woolly hair (HP:0002224)2.02875715
116Joint stiffness (HP:0001387)2.02032222
117Cerebral aneurysm (HP:0004944)2.01489752
118Abnormality of the lacrimal duct (HP:0011481)2.01152768
119Waddling gait (HP:0002515)2.00365065
120Neonatal death (HP:0003811)1.99949359
121Decreased lacrimation (HP:0000633)1.99513320
122Severe Myopia (HP:0011003)1.98796739
123Aplasia/hypoplasia of the femur (HP:0005613)1.98376025
124Vertebral compression fractures (HP:0002953)1.98092354
125Thoracolumbar scoliosis (HP:0002944)1.97652427
126Chronic bronchitis (HP:0004469)1.97414362
127Anonychia (HP:0001798)1.96853328
128Hip contracture (HP:0003273)1.95830619
129Fragile skin (HP:0001030)1.94267541
130Metaphyseal irregularity (HP:0003025)1.94026532
131Abnormal hand bone ossification (HP:0010660)1.92872946
132Distal lower limb muscle weakness (HP:0009053)1.92631512
133Abnormal cartilage morphology (HP:0002763)1.92257068
134Hand muscle atrophy (HP:0009130)1.92190864
135Increased connective tissue (HP:0009025)1.91932604
136Bronchomalacia (HP:0002780)1.91311357
137Ovoid vertebral bodies (HP:0003300)1.90905347
138Arthropathy (HP:0003040)1.90074734
139Abnormality of the acetabulum (HP:0003170)1.89053965
140Amelogenesis imperfecta (HP:0000705)1.88961664
141Premature rupture of membranes (HP:0001788)1.88536265
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87939089
143Absent epiphyses (HP:0010577)1.87939089
144Bowed forearm bones (HP:0003956)1.87690145
145Bowing of the arm (HP:0006488)1.87690145
146Abnormality of permanent molar morphology (HP:0011071)1.87650472
147Abnormality of the dental root (HP:0006486)1.87650472
148Taurodontia (HP:0000679)1.87650472
149Glomerulosclerosis (HP:0000096)1.87119024
150Laryngomalacia (HP:0001601)1.87027573
151Nail dystrophy (HP:0008404)1.86208373
152White forelock (HP:0002211)1.85946663
153Type 1 muscle fiber predominance (HP:0003803)1.85784485
154Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85590976
155Aplasia involving bones of the extremities (HP:0009825)1.84704638
156Aplasia involving bones of the upper limbs (HP:0009823)1.84704638
157Aplasia of the phalanges of the hand (HP:0009802)1.84704638
158Frequent falls (HP:0002359)1.84634733
159Mild short stature (HP:0003502)1.84462575
160Abnormality of the labia majora (HP:0012881)1.83893422
161Down-sloping shoulders (HP:0200021)1.83658706
162J-shaped sella turcica (HP:0002680)1.81227359
163Sparse eyelashes (HP:0000653)1.80424538
164Abnormality of molar (HP:0011077)1.76980108
165Abnormality of molar morphology (HP:0011070)1.76980108
166Hypodontia (HP:0000668)1.76375346
167Peripheral hypomyelination (HP:0007182)1.74171102
168Curly hair (HP:0002212)1.71453725
169Corneal erosion (HP:0200020)1.70606984
170Thin ribs (HP:0000883)1.69497422
171Renal salt wasting (HP:0000127)1.67584654
172Abnormality of the thoracic spine (HP:0100711)1.66982230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.75844122
2EPHA24.74891420
3TTN4.47496350
4MUSK4.33592053
5ERBB44.20052776
6MST1R3.95564589
7MAP3K33.16480086
8FRK3.06409815
9MAPK153.03501750
10DDR23.00357539
11MYLK2.95495232
12MAP3K62.71930461
13ERBB32.20428449
14NME22.16168635
15TESK11.98365253
16TRPM71.96014107
17FER1.94500566
18PTK61.88433948
19PRKG21.87525527
20TRIB31.86923464
21MET1.78118625
22TAOK11.76064531
23TNK21.65912751
24MAP2K31.59303345
25EPHB21.53928507
26MAPKAPK31.49032981
27NUAK11.46092515
28RIPK11.44126760
29PTK21.39270506
30LIMK11.34320450
31LRRK21.32211421
32PKN21.31034112
33PIK3CG1.30676693
34NME11.28862906
35STK101.26197420
36SMG11.24897519
37NTRK11.20622635
38PIM21.19969106
39PRKD21.19534014
40PRKD31.17427282
41MAP3K111.15337332
42PAK41.14226803
43EPHB11.12230033
44PDGFRA1.09350613
45ERN11.07985421
46PAK21.04954285
47FLT31.04725676
48DMPK1.04527808
49LMTK21.04236934
50IRAK31.01703493
51MAP3K20.99677946
52STK380.95816839
53DAPK20.94703656
54MAP2K10.94671939
55PRKCI0.92675673
56SIK30.92407628
57EEF2K0.91803494
58MARK20.91221827
59RPS6KB20.88073730
60ICK0.86041845
61PAK30.78894545
62MAP3K70.78183151
63MAP3K140.74797872
64LATS10.74464903
65TBK10.73741499
66TAOK20.72110570
67ILK0.68777591
68ROCK10.68601137
69BMX0.67959530
70PIK3CA0.65889031
71KSR20.65029389
72PAK10.60592938
73MAP3K130.56394779
74ROCK20.56144459
75MTOR0.55153419
76RPS6KA20.54312560
77FYN0.52136630
78CAMK2G0.51844774
79MAP3K80.51748159
80MAP4K10.49727068
81MAPKAPK20.49122310
82NEK60.48852472
83RAF10.47702547
84FGR0.47667510
85TGFBR20.47450143
86STK30.47306207
87PTK2B0.46815629
88MATK0.45013643
89DAPK10.44767621
90CSK0.44305219
91EGFR0.44280764
92SRC0.43677569
93FGFR40.42476762
94MAP3K10.41857700
95JAK30.40407708
96GSK3A0.40113937
97CAMK2D0.39981880
98FGFR30.39974272
99PDGFRB0.39867992
100ARAF0.38481171
101GRK50.38427055
102CDK60.38275182
103STK240.37826879
104MAP2K20.37824384
105SCYL20.37671367
106HIPK20.35658633
107RIPK40.35551990
108DAPK30.35165009
109ERBB20.34874548
110LATS20.34364346
111NTRK30.33713319
112BCKDK0.31115271
113MAPK80.30757164
114RPS6KA40.30247544
115CDK90.29339221
116ZAP700.29004011
117ABL10.28627276
118RPS6KA10.26994412
119MAP2K60.26015070
120BCR0.25889008
121STK38L0.25724546
122NEK90.25678126
123SIK10.25537783
124MAP3K90.25469579
125TGFBR10.24703193
126CHUK0.23940719
127PRKD10.22409841
128IGF1R0.21876029
129KSR10.21623712
130IRAK20.20263106
131PLK20.20212451
132RPS6KA60.19700953
133CAMK2B0.19688187
134CDC42BPA0.19123700
135RPS6KC10.18374984
136RPS6KL10.18374984
137MAP3K50.17928923
138PRKCD0.17882266
139MAPK70.17869108
140PRKAA20.16350667
141MAPK30.13907435

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.07854312
2Notch signaling pathway_Homo sapiens_hsa043303.71461256
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.67316903
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.26556960
5ECM-receptor interaction_Homo sapiens_hsa045123.23209237
6Chemical carcinogenesis_Homo sapiens_hsa052043.21694796
7Sulfur metabolism_Homo sapiens_hsa009203.10088398
8Glutathione metabolism_Homo sapiens_hsa004802.69241880
9Bladder cancer_Homo sapiens_hsa052192.54656504
10Gastric acid secretion_Homo sapiens_hsa049712.46726774
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.41359867
12Phenylalanine metabolism_Homo sapiens_hsa003602.38144881
13Collecting duct acid secretion_Homo sapiens_hsa049662.37222378
14Axon guidance_Homo sapiens_hsa043602.01121023
15Histidine metabolism_Homo sapiens_hsa003401.87072682
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86821243
17Focal adhesion_Homo sapiens_hsa045101.79080019
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.77099165
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71603703
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64015618
21Proteoglycans in cancer_Homo sapiens_hsa052051.59051017
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56576325
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56498910
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55427467
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53655977
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43589708
27Protein digestion and absorption_Homo sapiens_hsa049741.31463740
28Fat digestion and absorption_Homo sapiens_hsa049751.30967372
29Small cell lung cancer_Homo sapiens_hsa052221.28408343
30Glycerolipid metabolism_Homo sapiens_hsa005611.27393152
31Other glycan degradation_Homo sapiens_hsa005111.26093656
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.25099532
33Galactose metabolism_Homo sapiens_hsa000521.24106430
34Mineral absorption_Homo sapiens_hsa049781.23852056
35TNF signaling pathway_Homo sapiens_hsa046681.23555506
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21201101
37Adherens junction_Homo sapiens_hsa045201.19431258
38Vitamin digestion and absorption_Homo sapiens_hsa049771.18627065
39Toxoplasmosis_Homo sapiens_hsa051451.15771473
40ErbB signaling pathway_Homo sapiens_hsa040121.15382976
41Amoebiasis_Homo sapiens_hsa051461.14904370
42ABC transporters_Homo sapiens_hsa020101.13631639
43Shigellosis_Homo sapiens_hsa051311.09280026
44Tight junction_Homo sapiens_hsa045301.07443204
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06810963
46Pertussis_Homo sapiens_hsa051331.05018854
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.04421114
48Insulin signaling pathway_Homo sapiens_hsa049101.02966142
49Tyrosine metabolism_Homo sapiens_hsa003501.02835812
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.02643599
51Fructose and mannose metabolism_Homo sapiens_hsa000510.99867074
52Malaria_Homo sapiens_hsa051440.99444927
53beta-Alanine metabolism_Homo sapiens_hsa004100.98055529
54Insulin resistance_Homo sapiens_hsa049310.93982083
55Inositol phosphate metabolism_Homo sapiens_hsa005620.93545432
56Thyroid hormone synthesis_Homo sapiens_hsa049180.92076770
57Salmonella infection_Homo sapiens_hsa051320.91781997
58Leishmaniasis_Homo sapiens_hsa051400.91118254
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91034511
60Choline metabolism in cancer_Homo sapiens_hsa052310.89737477
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88907905
62Hippo signaling pathway_Homo sapiens_hsa043900.88415359
63Arginine biosynthesis_Homo sapiens_hsa002200.88311346
64Linoleic acid metabolism_Homo sapiens_hsa005910.88142826
65Acute myeloid leukemia_Homo sapiens_hsa052210.87819633
66Endocytosis_Homo sapiens_hsa041440.87074710
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84383306
68Sphingolipid metabolism_Homo sapiens_hsa006000.83114239
69Arachidonic acid metabolism_Homo sapiens_hsa005900.83059154
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82630309
71Caffeine metabolism_Homo sapiens_hsa002320.81907161
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81026795
73Platelet activation_Homo sapiens_hsa046110.80327321
74AMPK signaling pathway_Homo sapiens_hsa041520.79126435
75Sulfur relay system_Homo sapiens_hsa041220.78639562
76Lysosome_Homo sapiens_hsa041420.77399413
77Osteoclast differentiation_Homo sapiens_hsa043800.76199503
78Apoptosis_Homo sapiens_hsa042100.75710266
79TGF-beta signaling pathway_Homo sapiens_hsa043500.75600169
80Starch and sucrose metabolism_Homo sapiens_hsa005000.73598784
81Thyroid cancer_Homo sapiens_hsa052160.71549970
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71527060
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70722828
84Estrogen signaling pathway_Homo sapiens_hsa049150.67713948
85Chronic myeloid leukemia_Homo sapiens_hsa052200.67615311
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.67178391
87Dorso-ventral axis formation_Homo sapiens_hsa043200.66596397
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65157986
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64235621
90Legionellosis_Homo sapiens_hsa051340.62493788
91Pancreatic secretion_Homo sapiens_hsa049720.62097856
92Dilated cardiomyopathy_Homo sapiens_hsa054140.61782441
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61517346
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.61214097
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.60358088
96Ovarian steroidogenesis_Homo sapiens_hsa049130.59466581
97Rheumatoid arthritis_Homo sapiens_hsa053230.59270029
98Phagosome_Homo sapiens_hsa041450.58338064
99Hepatitis C_Homo sapiens_hsa051600.57972638
100Pathways in cancer_Homo sapiens_hsa052000.56631007
101Vibrio cholerae infection_Homo sapiens_hsa051100.56509576
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55114837
103Fatty acid biosynthesis_Homo sapiens_hsa000610.54955423
104VEGF signaling pathway_Homo sapiens_hsa043700.54572795
105Ether lipid metabolism_Homo sapiens_hsa005650.53665897
106Hematopoietic cell lineage_Homo sapiens_hsa046400.52953929
107Tuberculosis_Homo sapiens_hsa051520.52860256
108PPAR signaling pathway_Homo sapiens_hsa033200.52189692
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52171680
110Influenza A_Homo sapiens_hsa051640.51645422
111Steroid biosynthesis_Homo sapiens_hsa001000.50355751
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49562644
113Long-term depression_Homo sapiens_hsa047300.49401979
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49179287
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47781634
116Prolactin signaling pathway_Homo sapiens_hsa049170.47005348
117Melanogenesis_Homo sapiens_hsa049160.45833571
118N-Glycan biosynthesis_Homo sapiens_hsa005100.45473597
119MicroRNAs in cancer_Homo sapiens_hsa052060.45076051
120mTOR signaling pathway_Homo sapiens_hsa041500.44441501
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44344657
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43123464
123Bile secretion_Homo sapiens_hsa049760.42443561
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42096235
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41760841
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39977486
127HIF-1 signaling pathway_Homo sapiens_hsa040660.37070556
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36593966
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35842625
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32414535
131Pancreatic cancer_Homo sapiens_hsa052120.31403706
132Salivary secretion_Homo sapiens_hsa049700.30885144
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30436650
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.30074077
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29473087
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29302478
137Endometrial cancer_Homo sapiens_hsa052130.28699880
138Retinol metabolism_Homo sapiens_hsa008300.27670278
139Basal cell carcinoma_Homo sapiens_hsa052170.27656249
140Renal cell carcinoma_Homo sapiens_hsa052110.27184863
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.26542163
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25945178
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.24731134
144GnRH signaling pathway_Homo sapiens_hsa049120.24386431
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.24306884

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