SYTL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)7.98002323
2protein maturation by protein folding (GO:0022417)7.87185431
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.70574705
4COPII vesicle coating (GO:0048208)7.05770112
5peptide hormone processing (GO:0016486)6.96706212
6regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.86602091
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.81056633
8protein retention in ER lumen (GO:0006621)6.72000753
9regulation of type B pancreatic cell apoptotic process (GO:2000674)6.33434562
10signal peptide processing (GO:0006465)6.28360157
11type B pancreatic cell development (GO:0003323)6.25648489
12glandular epithelial cell differentiation (GO:0002067)5.92337994
13exocrine pancreas development (GO:0031017)5.90985003
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.77947094
15glandular epithelial cell development (GO:0002068)5.73747821
16sequestering of metal ion (GO:0051238)5.59239857
17positive regulation of nuclease activity (GO:0032075)5.52560930
18positive regulation of endothelial cell differentiation (GO:0045603)5.29902755
19positive regulation of insulin secretion (GO:0032024)5.24044474
20vesicle coating (GO:0006901)5.23073449
21insulin secretion (GO:0030073)5.22915558
22adenosine metabolic process (GO:0046085)5.18447863
23regulation of nuclease activity (GO:0032069)5.03870846
24regulation of plasminogen activation (GO:0010755)4.96401459
25endoplasmic reticulum unfolded protein response (GO:0030968)4.87625230
26ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.78612230
27cellular response to unfolded protein (GO:0034620)4.75766014
28ER overload response (GO:0006983)4.74395601
29* regulation of insulin secretion (GO:0050796)4.71409158
30negative regulation of glycoprotein biosynthetic process (GO:0010561)4.68124537
31cellular response to topologically incorrect protein (GO:0035967)4.67454119
32ER-nucleus signaling pathway (GO:0006984)4.58047277
33nitric oxide mediated signal transduction (GO:0007263)4.55582508
34regulation of endothelial cell differentiation (GO:0045601)4.54767577
35white fat cell differentiation (GO:0050872)4.53169693
36columnar/cuboidal epithelial cell development (GO:0002066)4.50013228
37negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.49197290
38sulfur amino acid catabolic process (GO:0000098)4.39952676
39* regulation of peptide hormone secretion (GO:0090276)4.29998809
40negative regulation of norepinephrine secretion (GO:0010700)4.29078506
41positive regulation of peptide hormone secretion (GO:0090277)4.23916895
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.23259423
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.23259423
44* regulation of peptide secretion (GO:0002791)4.21843384
45thrombin receptor signaling pathway (GO:0070493)4.21345782
46negative regulation of catecholamine secretion (GO:0033604)4.14981359
47cellular response to vitamin D (GO:0071305)4.13633598
48intra-Golgi vesicle-mediated transport (GO:0006891)4.12587454
49positive regulation of peptide secretion (GO:0002793)4.09248228
50protein N-linked glycosylation via asparagine (GO:0018279)4.08128147
51peptidyl-asparagine modification (GO:0018196)4.05221421
52homocysteine metabolic process (GO:0050667)4.02369758
53ER to Golgi vesicle-mediated transport (GO:0006888)3.95214635
54response to endoplasmic reticulum stress (GO:0034976)3.91210199
55detection of calcium ion (GO:0005513)3.83577824
56peptide hormone secretion (GO:0030072)3.82053566
57microtubule nucleation (GO:0007020)3.80618585
58cellular zinc ion homeostasis (GO:0006882)3.80012201
59* regulation of hormone secretion (GO:0046883)3.74758997
60peptide secretion (GO:0002790)3.73835168
61protein N-linked glycosylation (GO:0006487)3.72505786
62regulation of gonadotropin secretion (GO:0032276)3.72004485
63cysteine metabolic process (GO:0006534)3.71900133
64response to unfolded protein (GO:0006986)3.67641592
65toxin metabolic process (GO:0009404)3.64836579
66protein localization to Golgi apparatus (GO:0034067)3.64499258
67positive regulation of glycolytic process (GO:0045821)3.63065288
68macroautophagy (GO:0016236)3.61614712
69response to topologically incorrect protein (GO:0035966)3.61225837
70organic cation transport (GO:0015695)3.56544177
71purine nucleotide salvage (GO:0032261)3.55200561
72regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.54878866
73regulation of sequestering of triglyceride (GO:0010889)3.53594946
74response to hexose (GO:0009746)3.52462375
75Golgi organization (GO:0007030)3.51587932
76regulation of hexokinase activity (GO:1903299)3.49901340
77regulation of glucokinase activity (GO:0033131)3.49901340
78folic acid-containing compound biosynthetic process (GO:0009396)3.48784091
79* regulation of peptide transport (GO:0090087)3.48097924
80negative regulation of glycoprotein metabolic process (GO:1903019)3.47676726
81response to glucose (GO:0009749)3.44549761
82L-alpha-amino acid transmembrane transport (GO:1902475)3.44381575
83endothelium development (GO:0003158)3.43290836
84positive regulation of hormone secretion (GO:0046887)3.40515715
85negative regulation of DNA biosynthetic process (GO:2000279)3.37714309
86response to monosaccharide (GO:0034284)3.35817400
87negative regulation of bone resorption (GO:0045779)3.32318180
88astrocyte differentiation (GO:0048708)3.30581375
89* negative regulation of insulin secretion (GO:0046676)3.29989296
90platelet dense granule organization (GO:0060155)3.29255648
91epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.29065220
92regulation of integrin-mediated signaling pathway (GO:2001044)3.28782794
93negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.24461502
94regulation of macrophage derived foam cell differentiation (GO:0010743)3.24172110
95nucleoside diphosphate catabolic process (GO:0009134)3.22013508
96epithelial cell fate commitment (GO:0072148)3.21717871
97cell migration involved in heart development (GO:0060973)3.20968711
98regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.20835226
99response to hepatocyte growth factor (GO:0035728)3.20305907
100cellular response to hepatocyte growth factor stimulus (GO:0035729)3.20305907
101tryptophan catabolic process (GO:0006569)3.17712163
102indole-containing compound catabolic process (GO:0042436)3.17712163
103indolalkylamine catabolic process (GO:0046218)3.17712163
104regulation of Golgi to plasma membrane protein transport (GO:0042996)3.17590230
105glucose homeostasis (GO:0042593)3.15416154
106carbohydrate homeostasis (GO:0033500)3.15416154
107regulation of glucocorticoid secretion (GO:2000849)3.12820030
108behavioral response to nicotine (GO:0035095)3.12139527
109Golgi vesicle transport (GO:0048193)3.09455987
110intestinal epithelial cell development (GO:0060576)3.06502813
111cellular response to glucagon stimulus (GO:0071377)3.05241184
112regulation of energy homeostasis (GO:2000505)3.02804564
113cartilage morphogenesis (GO:0060536)3.02375731
1144-hydroxyproline metabolic process (GO:0019471)3.01765065
115tryptophan metabolic process (GO:0006568)3.01062479
116signal transduction involved in regulation of gene expression (GO:0023019)3.00542258
117GDP-mannose metabolic process (GO:0019673)3.00281123
118peptide transport (GO:0015833)2.99820411
119hormone secretion (GO:0046879)2.99475466
120intestinal absorption (GO:0050892)2.98497884
121regulation of oxidative phosphorylation (GO:0002082)2.97148063
1223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.96560433
123purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.96560433
124desmosome organization (GO:0002934)2.95512265
125negative regulation of protein localization to cell surface (GO:2000009)2.94477275
126tonic smooth muscle contraction (GO:0014820)2.94035337
127regulation of lipoprotein metabolic process (GO:0050746)2.93209600
128response to carbohydrate (GO:0009743)2.92967781
129xenobiotic catabolic process (GO:0042178)2.91655942
130growth hormone secretion (GO:0030252)2.91304482
131maintenance of protein localization in organelle (GO:0072595)2.87825672
132cardiolipin metabolic process (GO:0032048)2.87449200
133regulation of female receptivity (GO:0045924)2.87345652
134protein targeting to Golgi (GO:0000042)2.86731639
135protein-chromophore linkage (GO:0018298)2.86690242
136inner ear receptor cell development (GO:0060119)2.86064652
137* negative regulation of peptide hormone secretion (GO:0090278)2.85009323
138negative regulation of keratinocyte proliferation (GO:0010839)2.85000747
139cellular response to hexose stimulus (GO:0071331)2.84736180
140primary amino compound metabolic process (GO:1901160)2.83439888
141triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81286772
142interleukin-6-mediated signaling pathway (GO:0070102)2.79637472
143adaptation of signaling pathway (GO:0023058)2.76610816
144indolalkylamine metabolic process (GO:0006586)2.74936616
145cochlea development (GO:0090102)2.74895475
146galactose metabolic process (GO:0006012)2.74414268
147positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.71174077
148aromatic amino acid family catabolic process (GO:0009074)2.66252416
149aggressive behavior (GO:0002118)2.65771208
150phosphatidylglycerol biosynthetic process (GO:0006655)2.63308249
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63170913
152amine catabolic process (GO:0009310)2.62153841
153cellular biogenic amine catabolic process (GO:0042402)2.62153841
154photoreceptor cell differentiation (GO:0046530)2.62059809
155eye photoreceptor cell differentiation (GO:0001754)2.62059809
156cilium or flagellum-dependent cell motility (GO:0001539)2.60035771
157amino acid salvage (GO:0043102)2.58428346
158L-methionine salvage (GO:0071267)2.58428346
159L-methionine biosynthetic process (GO:0071265)2.58428346
160galactose catabolic process (GO:0019388)2.57165440
161blood coagulation, intrinsic pathway (GO:0007597)2.56489919
162positive regulation of muscle hypertrophy (GO:0014742)2.54318144
163positive regulation of cardiac muscle hypertrophy (GO:0010613)2.54318144
164positive regulation of digestive system process (GO:0060456)2.52870914
165negative regulation of platelet activation (GO:0010544)2.52645849
166acrosome assembly (GO:0001675)2.47404992
167one-carbon metabolic process (GO:0006730)2.44793438
168alternative mRNA splicing, via spliceosome (GO:0000380)2.44332159
169tachykinin receptor signaling pathway (GO:0007217)2.43451567
170positive regulation of fatty acid oxidation (GO:0046321)2.42683647
171kynurenine metabolic process (GO:0070189)2.42047478
172cellular ketone body metabolic process (GO:0046950)2.42046710
173benzene-containing compound metabolic process (GO:0042537)2.40628033
174aminoglycoside antibiotic metabolic process (GO:0030647)2.38802688
175relaxation of smooth muscle (GO:0044557)2.37418919
176sulfur amino acid biosynthetic process (GO:0000097)2.36425781
177negative regulation of catenin import into nucleus (GO:0035414)2.36315837
178innervation (GO:0060384)2.36287614
179mitochondrial RNA metabolic process (GO:0000959)2.34541685
180autophagic vacuole fusion (GO:0000046)2.34007568
181protein-cofactor linkage (GO:0018065)2.33797280
182negative regulation of cell cycle arrest (GO:0071157)2.33553750
183regulation of platelet aggregation (GO:0090330)2.33015867
184pteridine-containing compound biosynthetic process (GO:0042559)2.31758504
185regulation of platelet activation (GO:0010543)2.31633629
186cellular response to BMP stimulus (GO:0071773)2.30990299
187response to BMP (GO:0071772)2.30990299
188endosome to melanosome transport (GO:0035646)2.29587754
189endosome to pigment granule transport (GO:0043485)2.29587754
190heme transport (GO:0015886)2.29448026
191artery smooth muscle contraction (GO:0014824)2.29044431
192indole-containing compound metabolic process (GO:0042430)2.27684591
193interkinetic nuclear migration (GO:0022027)2.27365416
194positive regulation of oligodendrocyte differentiation (GO:0048714)2.27028865
195regulation of vitamin D biosynthetic process (GO:0060556)2.26558041
196negative regulation of lipid storage (GO:0010888)2.26483630
197Golgi transport vesicle coating (GO:0048200)11.6406821
198COPI coating of Golgi vesicle (GO:0048205)11.6406821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.37354556
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.60334821
3GATA1_22025678_ChIP-Seq_K562_Human4.23192615
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.91121791
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48485933
6IGF1R_20145208_ChIP-Seq_DFB_Human2.74462319
7PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.46889781
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29059277
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23018731
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11618896
11* VDR_22108803_ChIP-Seq_LS180_Human2.02381191
12GATA2_21666600_ChIP-Seq_HMVEC_Human1.98207541
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95766709
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94418847
15NR3C1_23031785_ChIP-Seq_PC12_Mouse1.89977857
16CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85452589
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.83780917
18ER_23166858_ChIP-Seq_MCF-7_Human1.81643334
19SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79708987
20P300_19829295_ChIP-Seq_ESCs_Human1.77648589
21MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77332470
22FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.76266615
23REST_19997604_ChIP-ChIP_NEURONS_Mouse1.76194315
24EZH2_22144423_ChIP-Seq_EOC_Human1.74216917
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72191451
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71411719
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.67977189
28* CDX2_22108803_ChIP-Seq_LS180_Human1.66985618
29ZNF274_21170338_ChIP-Seq_K562_Hela1.64810640
30REST_21632747_ChIP-Seq_MESCs_Mouse1.63902917
31* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62883217
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.58654480
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54967752
34FUS_26573619_Chip-Seq_HEK293_Human1.54827091
35OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.52641732
36EWS_26573619_Chip-Seq_HEK293_Human1.51409268
37AR_25329375_ChIP-Seq_VCAP_Human1.51309117
38CJUN_26792858_Chip-Seq_BT549_Human1.50692736
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50212504
40ERG_20517297_ChIP-Seq_VCAP_Human1.49198599
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48556400
42TAF15_26573619_Chip-Seq_HEK293_Human1.48543636
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.47787362
44FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.45373321
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.44948210
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44921317
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44847516
48TFEB_21752829_ChIP-Seq_HELA_Human1.42317083
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40194535
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39438327
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37219311
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36167299
53FOXA1_25552417_ChIP-Seq_VCAP_Human1.35907909
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35851257
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34868509
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32530068
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32530068
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31622763
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31351851
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.30943921
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30921835
62TP53_22573176_ChIP-Seq_HFKS_Human1.30531182
63TP53_16413492_ChIP-PET_HCT116_Human1.29627904
64TCF4_22108803_ChIP-Seq_LS180_Human1.29255480
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28913404
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28721782
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28105122
68CBP_20019798_ChIP-Seq_JUKART_Human1.28105122
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27674725
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27515213
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26669410
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25009326
73* STAT3_23295773_ChIP-Seq_U87_Human1.24681748
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23745913
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21684802
76* RUNX2_22187159_ChIP-Seq_PCA_Human1.21331676
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21214687
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20973324
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.20682307
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20246958
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19927293
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18936124
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.18752153
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18252493
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.17060000
86NANOG_19829295_ChIP-Seq_ESCs_Human1.15884951
87SOX2_19829295_ChIP-Seq_ESCs_Human1.15884951
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.15193704
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15180144
90AHR_22903824_ChIP-Seq_MCF-7_Human1.14225367
91GATA1_19941826_ChIP-Seq_K562_Human1.14039723
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12903618
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12831110
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.12243790
95SCL_19346495_ChIP-Seq_HPC-7_Human1.11896623
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10840539
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10459523
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.10142127
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.09801128
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.09026726
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08733456
102SOX2_20726797_ChIP-Seq_SW620_Human1.08659699
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08445541
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08358894
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.08053962
106P53_22387025_ChIP-Seq_ESCs_Mouse1.07751051
107SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07491027
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07318896
109KDM2B_26808549_Chip-Seq_REH_Human1.06949058
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06503726
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06235819
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06135386
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.06031346
114IRF8_22096565_ChIP-ChIP_GC-B_Human1.05863272
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.05229232
116GATA4_25053715_ChIP-Seq_YYC3_Human1.04803344
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04576093
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04289480
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.03735022
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03515391
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03462592
122LXR_22158963_ChIP-Seq_LIVER_Mouse1.03251046
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03209959
124OCT1_27270436_Chip-Seq_PROSTATE_Human1.02562206
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02081496
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02037531
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01986394
128BCAT_22108803_ChIP-Seq_LS180_Human1.01185043
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00654274
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00133731
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99721308
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98132599
133GBX2_23144817_ChIP-Seq_PC3_Human0.96400962
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95867000
135EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95528260
136GF1B_26923725_Chip-Seq_HPCs_Mouse0.94539764
137CLOCK_20551151_ChIP-Seq_293T_Human0.94463425
138GATA3_27048872_Chip-Seq_THYMUS_Human0.93786593
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91592152
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86559733
141CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85960345
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84642571
143KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84530209
144RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84497733
145ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83445638
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.82882069
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82882069
148SMAD4_21799915_ChIP-Seq_A2780_Human0.82791019
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.82183376
150TCF4_23295773_ChIP-Seq_U87_Human0.82103346
151GF1_26923725_Chip-Seq_HPCs_Mouse0.81748172
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80878076
153CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80580062
154TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80548972
155STAT3_18555785_Chip-Seq_ESCs_Mouse0.80015808
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.79821656
157CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79565678
158SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79116683
159SMAD3_21741376_ChIP-Seq_ESCs_Human0.78830669
160RXR_22158963_ChIP-Seq_LIVER_Mouse0.78797536
161RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78449244
162STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78214763
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.77528444
164GATA3_26560356_Chip-Seq_TH2_Human0.77469528
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76713070
166GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76207110
167TET1_21490601_ChIP-Seq_MESCs_Mouse0.76172593
168E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75351518
169FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75113241
170ETV2_25802403_ChIP-Seq_MESCs_Mouse0.74620577
171FOXA2_19822575_ChIP-Seq_HepG2_Human0.74321599
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73976716
173AR_20517297_ChIP-Seq_VCAP_Human0.73417832
174PADI4_21655091_ChIP-ChIP_MCF-7_Human0.72700490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog6.07113660
2MP0003283_abnormal_digestive_organ5.82599672
3MP0009780_abnormal_chondrocyte_physiolo4.55800076
4* MP0002693_abnormal_pancreas_physiology4.50077932
5MP0004043_abnormal_pH_regulation4.41368271
6MP0003195_calcinosis4.01640811
7MP0002909_abnormal_adrenal_gland4.00324350
8* MP0001944_abnormal_pancreas_morphology3.95918160
9MP0005379_endocrine/exocrine_gland_phen3.54583924
10MP0000678_abnormal_parathyroid_gland3.53595231
11MP0010386_abnormal_urinary_bladder3.35258390
12MP0000013_abnormal_adipose_tissue3.23089805
13MP0010368_abnormal_lymphatic_system3.08318242
14MP0005220_abnormal_exocrine_pancreas3.02281642
15MP0005360_urolithiasis2.93999497
16MP0003183_abnormal_peptide_metabolism2.86496622
17MP0002736_abnormal_nociception_after2.69697727
18MP0003724_increased_susceptibility_to2.69279594
19MP0005464_abnormal_platelet_physiology2.65370776
20MP0004885_abnormal_endolymph2.50664969
21* MP0002078_abnormal_glucose_homeostasis2.46014866
22MP0004147_increased_porphyrin_level2.35343823
23MP0002837_dystrophic_cardiac_calcinosis2.34285062
24MP0008872_abnormal_physiological_respon2.25050969
25MP0004264_abnormal_extraembryonic_tissu2.21947857
26MP0000462_abnormal_digestive_system2.11378939
27MP0005167_abnormal_blood-brain_barrier2.10229779
28MP0006072_abnormal_retinal_apoptosis2.07154053
29MP0001879_abnormal_lymphatic_vessel2.02195670
30MP0008004_abnormal_stomach_pH1.97558480
31MP0001968_abnormal_touch/_nociception1.94111800
32MP0001986_abnormal_taste_sensitivity1.93697185
33MP0004130_abnormal_muscle_cell1.90355163
34MP0002928_abnormal_bile_duct1.86978003
35MP0005551_abnormal_eye_electrophysiolog1.86262537
36MP0008775_abnormal_heart_ventricle1.82285758
37MP0009697_abnormal_copulation1.82194484
38MP0002638_abnormal_pupillary_reflex1.80569941
39MP0003300_gastrointestinal_ulcer1.79738339
40MP0000003_abnormal_adipose_tissue1.72062645
41MP0003122_maternal_imprinting1.71957936
42MP0008995_early_reproductive_senescence1.70047630
43MP0002234_abnormal_pharynx_morphology1.68731191
44MP0005503_abnormal_tendon_morphology1.63840632
45MP0005595_abnormal_vascular_smooth1.63341174
46MP0002896_abnormal_bone_mineralization1.58143548
47MP0003950_abnormal_plasma_membrane1.57323216
48MP0001765_abnormal_ion_homeostasis1.57309265
49MP0004084_abnormal_cardiac_muscle1.56774747
50MP0003953_abnormal_hormone_level1.55864990
51MP0006276_abnormal_autonomic_nervous1.55127700
52MP0008875_abnormal_xenobiotic_pharmacok1.54845260
53MP0000613_abnormal_salivary_gland1.52128751
54MP0004215_abnormal_myocardial_fiber1.51834985
55MP0005085_abnormal_gallbladder_physiolo1.45960999
56MP0002295_abnormal_pulmonary_circulatio1.45330287
57MP0003868_abnormal_feces_composition1.42426685
58MP0002735_abnormal_chemical_nociception1.41639583
59MP0005083_abnormal_biliary_tract1.40317562
60MP0005257_abnormal_intraocular_pressure1.37375967
61MP0000465_gastrointestinal_hemorrhage1.36509604
62MP0008961_abnormal_basal_metabolism1.33928507
63MP0003172_abnormal_lysosome_physiology1.33726565
64MP0005645_abnormal_hypothalamus_physiol1.33555770
65MP0009643_abnormal_urine_homeostasis1.32485423
66MP0004272_abnormal_basement_membrane1.30122281
67MP0003787_abnormal_imprinting1.29004811
68MP0003705_abnormal_hypodermis_morpholog1.27358957
69MP0002163_abnormal_gland_morphology1.27272436
70MP0005310_abnormal_salivary_gland1.26764460
71MP0005332_abnormal_amino_acid1.25454105
72MP0010329_abnormal_lipoprotein_level1.21217926
73MP0001501_abnormal_sleep_pattern1.20109486
74MP0003252_abnormal_bile_duct1.16747816
75MP0003186_abnormal_redox_activity1.16087786
76MP0005535_abnormal_body_temperature1.14759416
77MP0001270_distended_abdomen1.14400530
78MP0003119_abnormal_digestive_system1.13165342
79MP0000249_abnormal_blood_vessel1.07803277
80MP0005410_abnormal_fertilization1.05962734
81MP0002132_abnormal_respiratory_system1.05303734
82MP0002733_abnormal_thermal_nociception1.05222872
83MP0006054_spinal_hemorrhage1.05184117
84MP0004484_altered_response_of1.04928460
85MP0003890_abnormal_embryonic-extraembry1.04020516
86MP0005365_abnormal_bile_salt1.03954374
87MP0000639_abnormal_adrenal_gland1.01290282
88MP0004270_analgesia1.01173209
89MP0002160_abnormal_reproductive_system1.00737212
90MP0003866_abnormal_defecation1.00051558
91MP0002876_abnormal_thyroid_physiology1.00002636
92MP0005367_renal/urinary_system_phenotyp0.99662243
93MP0000516_abnormal_urinary_system0.99662243
94MP0005448_abnormal_energy_balance0.98200182
95MP0005647_abnormal_sex_gland0.98063032
96MP0005165_increased_susceptibility_to0.96645180
97MP0005058_abnormal_lysosome_morphology0.96308348
98MP0003959_abnormal_lean_body0.95388513
99MP0005636_abnormal_mineral_homeostasis0.94449922
100MP0003638_abnormal_response/metabolism_0.94098522
101MP0001756_abnormal_urination0.93542991
102MP0005187_abnormal_penis_morphology0.92327913
103MP0002138_abnormal_hepatobiliary_system0.91652744
104MP0001764_abnormal_homeostasis0.91383330
105MP0004085_abnormal_heartbeat0.90564797
106MP0001502_abnormal_circadian_rhythm0.88950888
107MP0003045_fibrosis0.88040950
108MP0009115_abnormal_fat_cell0.88035032
109MP0009672_abnormal_birth_weight0.87175056
110MP0003279_aneurysm0.86981293
111MP0005408_hypopigmentation0.86444889
112MP0002971_abnormal_brown_adipose0.86371484
113MP0001661_extended_life_span0.85048888
114MP0005084_abnormal_gallbladder_morpholo0.84389624
115MP0002108_abnormal_muscle_morphology0.84335266
116MP0005164_abnormal_response_to0.81941247
117MP0000230_abnormal_systemic_arterial0.81395442
118MP0002139_abnormal_hepatobiliary_system0.80317078
119MP0000681_abnormal_thyroid_gland0.79623471
120MP0000383_abnormal_hair_follicle0.78633876
121MP0000427_abnormal_hair_cycle0.78051741
122MP0005395_other_phenotype0.77968546
123MP0006292_abnormal_olfactory_placode0.72927787
124MP0009764_decreased_sensitivity_to0.72754970
125MP0000647_abnormal_sebaceous_gland0.72687257
126* MP0000631_abnormal_neuroendocrine_gland0.72517564
127MP0005253_abnormal_eye_physiology0.72131084
128MP0005275_abnormal_skin_tensile0.72105148
129MP0003879_abnormal_hair_cell0.71737022
130MP0002102_abnormal_ear_morphology0.70770930
131MP0005375_adipose_tissue_phenotype0.70171688
132MP0001970_abnormal_pain_threshold0.69327920
133MP0003718_maternal_effect0.69065543
134MP0001666_abnormal_nutrient_absorption0.68946616
135MP0001299_abnormal_eye_distance/0.68638012
136MP0002127_abnormal_cardiovascular_syste0.68290377
137MP0003123_paternal_imprinting0.68250339
138MP0001486_abnormal_startle_reflex0.68235996
139MP0006138_congestive_heart_failure0.68207662
140MP0005334_abnormal_fat_pad0.67038423
141MP0002115_abnormal_skeleton_extremities0.65951499
142MP0000538_abnormal_urinary_bladder0.63402791
143MP0009703_decreased_birth_body0.63103475
144MP0002118_abnormal_lipid_homeostasis0.62796221
145MP0008877_abnormal_DNA_methylation0.61563529
146MP0005670_abnormal_white_adipose0.61319093
147MP0002168_other_aberrant_phenotype0.61285456
148MP0004145_abnormal_muscle_electrophysio0.60847664
149MP0001919_abnormal_reproductive_system0.60707993
150MP0003795_abnormal_bone_structure0.60435107
151MP0003121_genomic_imprinting0.58798555
152* MP0009642_abnormal_blood_homeostasis0.56653757
153MP0005452_abnormal_adipose_tissue0.55198295
154MP0005076_abnormal_cell_differentiation0.54701867
155MP0002177_abnormal_outer_ear0.52717085
156MP0002653_abnormal_ependyma_morphology0.51924161
157MP0002970_abnormal_white_adipose0.51617587
158MP0005389_reproductive_system_phenotype0.49936075
159MP0001664_abnormal_digestion0.49515798
160MP0000163_abnormal_cartilage_morphology0.48654222
161MP0002069_abnormal_eating/drinking_beha0.48074409
162MP0004036_abnormal_muscle_relaxation0.47442451
163MP0005248_abnormal_Harderian_gland0.46193375
164MP0001731_abnormal_postnatal_growth0.45850449
165MP0000470_abnormal_stomach_morphology0.44466103
166MP0001186_pigmentation_phenotype0.43900229
167* MP0005646_abnormal_pituitary_gland0.43554658

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)9.01658880
2Hypoglycemic seizures (HP:0002173)8.37992455
3Symptomatic seizures (HP:0011145)7.55834224
4Hypoglycemic coma (HP:0001325)7.21345864
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.97789113
6Abnormality of alanine metabolism (HP:0010916)6.95399837
7Hyperalaninemia (HP:0003348)6.95399837
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.95399837
9Insulin-resistant diabetes mellitus (HP:0000831)5.81423086
10Hyperglycemia (HP:0003074)5.40874607
11Congenital sensorineural hearing impairment (HP:0008527)5.23761437
12Abnormality of the pancreatic islet cells (HP:0006476)4.97594877
13Abnormality of endocrine pancreas physiology (HP:0012093)4.97594877
14Spontaneous hematomas (HP:0007420)4.78340435
15Ketoacidosis (HP:0001993)4.76147006
16Pancreatic islet-cell hyperplasia (HP:0004510)4.68807237
17Abnormality of calcium-phosphate metabolism (HP:0100530)4.56232202
18Constricted visual fields (HP:0001133)4.43474245
19Late onset (HP:0003584)4.35597411
20Abnormal pancreas size (HP:0012094)4.33835746
21Large for gestational age (HP:0001520)4.33724576
22Decreased circulating renin level (HP:0003351)4.22731019
23Generalized aminoaciduria (HP:0002909)4.12435442
24Prolonged bleeding time (HP:0003010)3.99971107
25Menorrhagia (HP:0000132)3.98103894
26Petechiae (HP:0000967)3.93419361
27Urinary glycosaminoglycan excretion (HP:0003541)3.91734205
28Mucopolysacchariduria (HP:0008155)3.91734205
29Conjunctival telangiectasia (HP:0000524)3.80606024
30Osteomalacia (HP:0002749)3.73375278
31Attenuation of retinal blood vessels (HP:0007843)3.72677085
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.69947967
33Abnormality of polysaccharide metabolism (HP:0011012)3.69947967
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.69947967
35Esophageal varix (HP:0002040)3.66349961
36Hypokalemia (HP:0002900)3.58085544
37Increased mean platelet volume (HP:0011877)3.50768970
38Insulin resistance (HP:0000855)3.45820410
39Hyperlipoproteinemia (HP:0010980)3.39929701
40Decreased electroretinogram (ERG) amplitude (HP:0000654)3.37617089
41Abnormality of the vasculature of the conjunctiva (HP:0008054)3.29757269
42Gingival bleeding (HP:0000225)3.28609909
43Increased corneal curvature (HP:0100692)3.21441642
44Keratoconus (HP:0000563)3.21441642
45Dysostosis multiplex (HP:0000943)3.18104826
46Abnormality of the intrinsic pathway (HP:0010989)3.12934171
47Epistaxis (HP:0000421)3.07659242
48Agitation (HP:0000713)2.96483816
49Conjugated hyperbilirubinemia (HP:0002908)2.96460978
50Thoracolumbar scoliosis (HP:0002944)2.92402456
51Abnormal platelet volume (HP:0011876)2.89798242
52Ileus (HP:0002595)2.88756053
53Prominent metopic ridge (HP:0005487)2.88479750
54White forelock (HP:0002211)2.87575637
55Tubulointerstitial nephritis (HP:0001970)2.86067339
56Portal hypertension (HP:0001409)2.83980352
57Abnormality of renin-angiotensin system (HP:0000847)2.78924234
58Hyperparathyroidism (HP:0000843)2.75476729
59Abnormality of the renal cortex (HP:0011035)2.71752341
60Ketosis (HP:0001946)2.69338133
61Abnormality of potassium homeostasis (HP:0011042)2.69106964
62Myocardial infarction (HP:0001658)2.68060276
63Purpura (HP:0000979)2.65109812
64Chronic bronchitis (HP:0004469)2.61055283
65Abnormality of small intestinal villus morphology (HP:0011472)2.60250106
66Villous atrophy (HP:0011473)2.60250106
67Renal cortical cysts (HP:0000803)2.55789800
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.55556212
69Hypoplasia of the fovea (HP:0007750)2.55556212
70Abnormality of the hepatic vasculature (HP:0006707)2.55531228
71Limb hypertonia (HP:0002509)2.55127605
72Hyperactive renin-angiotensin system (HP:0000841)2.54090491
73Pigmentary retinal degeneration (HP:0001146)2.52332653
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.50628400
75Patchy hypopigmentation of hair (HP:0011365)2.48176303
76Metaphyseal dysplasia (HP:0100255)2.48113812
77Abnormality of the metopic suture (HP:0005556)2.47889419
78Decreased central vision (HP:0007663)2.45800961
79Unilateral renal agenesis (HP:0000122)2.44341394
80Pancreatic cysts (HP:0001737)2.43004308
81Abnormality of the fovea (HP:0000493)2.42173059
82Abnormal umbilical cord blood vessels (HP:0011403)2.38702858
83Single umbilical artery (HP:0001195)2.38702858
84Abnormality of the fetal cardiovascular system (HP:0010948)2.38702858
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38390971
86Abnormal protein N-linked glycosylation (HP:0012347)2.38390971
87Abnormal protein glycosylation (HP:0012346)2.38390971
88Abnormal glycosylation (HP:0012345)2.38390971
89EEG with generalized epileptiform discharges (HP:0011198)2.38002266
90Abnormal respiratory motile cilium morphology (HP:0005938)2.37367620
91Abnormal respiratory epithelium morphology (HP:0012253)2.37367620
92Nausea (HP:0002018)2.36855907
93Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36729609
94Progressive neurologic deterioration (HP:0002344)2.35774211
95Hypsarrhythmia (HP:0002521)2.35710348
96Hypothermia (HP:0002045)2.35563366
97Chronic hepatic failure (HP:0100626)2.34665470
98Exocrine pancreatic insufficiency (HP:0001738)2.33329487
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.32918850
100Chorioretinal atrophy (HP:0000533)2.32669050
101Abnormality of serum amino acid levels (HP:0003112)2.30535320
102Retinal atrophy (HP:0001105)2.28954528
103Pancreatic fibrosis (HP:0100732)2.28306540
104Epileptiform EEG discharges (HP:0011182)2.27617858
105Action tremor (HP:0002345)2.27611899
106Abolished electroretinogram (ERG) (HP:0000550)2.27124574
107Abdominal distention (HP:0003270)2.27016603
108Abnormality of sulfur amino acid metabolism (HP:0004339)2.23905667
109Oligomenorrhea (HP:0000876)2.23374758
110True hermaphroditism (HP:0010459)2.23213574
111Hyperphosphatemia (HP:0002905)2.22106774
112Hyperkalemia (HP:0002153)2.21361930
113Gout (HP:0001997)2.20160582
114Hypophosphatemia (HP:0002148)2.14640646
115Pheochromocytoma (HP:0002666)2.11756648
116Tubulointerstitial abnormality (HP:0001969)2.10794672
117Abnormality of midbrain morphology (HP:0002418)2.09649308
118Molar tooth sign on MRI (HP:0002419)2.09649308
119Proximal tubulopathy (HP:0000114)2.08798962
120Complete atrioventricular canal defect (HP:0001674)2.07771777
121Congenital stationary night blindness (HP:0007642)2.05996204
122Homocystinuria (HP:0002156)2.05646832
123Abnormality of homocysteine metabolism (HP:0010919)2.05646832
124Dysautonomia (HP:0002459)2.04640415
125Hyperventilation (HP:0002883)2.02437725
126Type I transferrin isoform profile (HP:0003642)2.00793359
127Dyschromatopsia (HP:0007641)1.99262173
128Papilledema (HP:0001085)1.99119692
129Menstrual irregularities (HP:0000858)1.98131760
130Hyperphosphaturia (HP:0003109)1.97655969
131Irregular vertebral endplates (HP:0003301)1.97102064
132Visual hallucinations (HP:0002367)1.93776627
133Hypercortisolism (HP:0001578)1.93757806
134Abnormality of the renal collecting system (HP:0004742)1.92848991
135Cortical visual impairment (HP:0100704)1.92305530
136Intestinal atresia (HP:0011100)1.91741344
137Abnormality of purine metabolism (HP:0004352)1.91611589
138Abnormal platelet function (HP:0011869)1.90108132
139Impaired platelet aggregation (HP:0003540)1.90108132
140Protuberant abdomen (HP:0001538)1.89375529
141Aortic aneurysm (HP:0004942)1.88976094
142Short tibia (HP:0005736)1.88481023
143Hypophosphatemic rickets (HP:0004912)1.88116197
144Abnormality of the renal medulla (HP:0100957)1.88011702
145Elevated alkaline phosphatase (HP:0003155)1.87021642
146Poor speech (HP:0002465)1.86446752
147Poikilocytosis (HP:0004447)1.85401269
148Cone-rod dystrophy (HP:0000548)1.85367950
149Congenital glaucoma (HP:0001087)1.84909851
150Increased circulating renin level (HP:0000848)1.84402504
151Bruising susceptibility (HP:0000978)1.84370546
152Chronic otitis media (HP:0000389)1.84128762
153Hypokalemic alkalosis (HP:0001949)1.83902190
154Missing ribs (HP:0000921)1.82123220
155Abnormal biliary tract morphology (HP:0012440)1.81469478
156Restlessness (HP:0000711)1.80193345
157Acute hepatic failure (HP:0006554)1.79300629
158Duplicated collecting system (HP:0000081)1.78984949
159Anorexia (HP:0002039)1.78430196
160Papillary thyroid carcinoma (HP:0002895)1.77320113
161Disproportionate short-trunk short stature (HP:0003521)1.77254330
162Abnormality of the common coagulation pathway (HP:0010990)1.77089779
163Thyroid-stimulating hormone excess (HP:0002925)1.76804498
164Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76211834
165Toxemia of pregnancy (HP:0100603)1.76205866
166Pulmonary embolism (HP:0002204)1.75659497
167Abnormality of alkaline phosphatase activity (HP:0004379)1.75164831
168Hypotension (HP:0002615)1.74991058
169Hypoalphalipoproteinemia (HP:0003233)1.73863589
170Neuroendocrine neoplasm (HP:0100634)1.72463446
171Hypomagnesemia (HP:0002917)1.71462751
172Nephronophthisis (HP:0000090)1.70922017
173Adrenal overactivity (HP:0002717)1.69811437
174Cystic liver disease (HP:0006706)1.69805372
175Primary adrenal insufficiency (HP:0008207)1.69766086
176Abnormal drinking behavior (HP:0030082)1.69229334
177Polydipsia (HP:0001959)1.69229334
178Stage 5 chronic kidney disease (HP:0003774)1.69141799
179Heterochromia iridis (HP:0001100)1.69087571
180Decreased subcutaneous fat (HP:0001002)1.67521659
181Metabolic alkalosis (HP:0200114)1.67222795
182Reduced subcutaneous adipose tissue (HP:0003758)1.66740766
183Abnormality of liposaccharide metabolism (HP:0010968)1.66476927
184Abnormality of glycosphingolipid metabolism (HP:0004343)1.66476927
185Abnormality of glycolipid metabolism (HP:0010969)1.66476927
186Abnormality of chloride homeostasis (HP:0011422)1.65961098
187Glycosuria (HP:0003076)1.65355477
188Abnormality of urine glucose concentration (HP:0011016)1.65355477
189Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65229545
190Spontaneous abortion (HP:0005268)1.61904804
191Hyperaldosteronism (HP:0000859)1.60635296
192Visceral angiomatosis (HP:0100761)1.60524873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.27116831
2PASK6.83832094
3MAPK154.41400741
4TAOK33.67793505
5PRKD33.55537557
6ACVR1B3.40321348
7HIPK23.38399709
8TIE12.91446987
9FLT32.74150604
10MYLK2.71706931
11MAP3K22.52530430
12ERN12.44271166
13BMPR1B2.43846914
14ADRBK22.04610127
15FRK2.02215406
16MST42.01384531
17NTRK11.89023253
18EPHA31.85199371
19GRK11.76297270
20PTK2B1.72184486
21MAP2K31.72168624
22ADRBK11.70366078
23LMTK21.66716669
24MAP3K11.65414987
25SCYL21.64642071
26PDGFRA1.62200944
27NTRK31.57260791
28CDK91.54823080
29BRSK21.51067053
30STK391.41850757
31PIK3CA1.40786808
32TRPM71.39697258
33CAMKK21.39019727
34MAP4K21.32071526
35WNK41.30777626
36PINK11.29928056
37PTK21.27585450
38EPHB21.27404754
39BMX1.20271274
40PRKD21.19315331
41PRKCH1.18770427
42IRAK31.17709444
43STK31.16589850
44MET1.13439525
45IRAK11.12234287
46ZAK1.11571032
47CDC42BPA1.11064874
48PHKG21.11003623
49PHKG11.11003623
50UHMK11.10342141
51EIF2AK31.10064598
52DYRK1B1.00140906
53PTK60.96284306
54OXSR10.94509966
55PAK30.93128443
56LATS10.93018877
57GRK50.91892304
58EIF2AK10.90028706
59NTRK20.86482725
60BRAF0.85958286
61RPS6KB20.84728911
62TLK10.84236157
63FGR0.82984017
64DAPK20.81997703
65SGK30.80299164
66PRKG20.80288402
67NLK0.78523996
68BCKDK0.77959237
69TRIB30.75456453
70JAK30.75304979
71MAP2K20.75285866
72SIK10.72792012
73RET0.72690891
74BRSK10.71506948
75WNK30.68882889
76AKT30.67576547
77JAK20.67440885
78CAMK10.67317540
79ITK0.65084838
80PRKCE0.64946137
81KDR0.64727256
82PNCK0.63697715
83ERBB30.63518445
84TGFBR10.63021835
85TNIK0.62030066
86FGFR40.57894037
87PRKAA10.57819010
88KIT0.56359745
89PLK20.55018273
90FER0.54996072
91ROCK10.53519207
92PKN10.52599123
93CDK80.52198528
94IKBKB0.49847588
95PRKCI0.48974322
96CAMK2A0.48866127
97KSR20.48800645
98CAMK2G0.47574109
99CSF1R0.46224916
100BRD40.46208190
101MAP3K30.46058143
102ABL10.45781343
103CSNK1G10.45441767
104JAK10.44131202
105MAPKAPK50.43636410
106IRAK20.42442674
107TNK20.40144069
108SYK0.39870007
109MARK20.38633444
110CAMK2D0.37397552
111RPS6KA20.36352200
112CHUK0.36339834
113TEC0.36313416
114CASK0.35911752
115BMPR20.35602345
116IGF1R0.35566543
117EPHB10.35469326
118NEK60.33964954
119PRKG10.33958428
120AKT20.33794669
121PRKACG0.32378167
122PRKD10.31958887
123CCNB10.30521557
124ZAP700.30483142
125PDGFRB0.29364955
126CSNK1A10.29099834
127GSK3A0.28172904
128PRKDC0.28105465
129BCR0.28089323
130PRKACA0.27828224
131PIK3CG0.26504273
132RPS6KB10.25959723
133CAMKK10.25846481
134WNK10.25669840
135FGFR30.25534284
136MTOR0.25313473
137MAPK140.25311214
138MUSK0.23711534
139ERBB40.21279970
140MAPK130.20104820
141NUAK10.19944548
142IRAK40.19676312
143SGK20.19458525
144BTK0.19458507
145MAP2K10.19251663
146MAPKAPK30.19058542
147CDK50.18324319
148AKT10.17866462
149STK38L0.17406120
150CAMK2B0.15477181
151PRKCA0.15256940
152MAPK30.14791375
153PRKAA20.14231190
154DYRK1A0.13887154
155SGK4940.13817501
156SGK2230.13817501

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.69826194
2Protein export_Homo sapiens_hsa030605.71646410
3Sulfur metabolism_Homo sapiens_hsa009203.57992777
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.46357397
5Insulin secretion_Homo sapiens_hsa049113.12940686
6Nitrogen metabolism_Homo sapiens_hsa009103.00222151
7Type II diabetes mellitus_Homo sapiens_hsa049302.52005562
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25838005
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.25484967
10Caffeine metabolism_Homo sapiens_hsa002322.19301236
11Type I diabetes mellitus_Homo sapiens_hsa049402.11483885
12Vibrio cholerae infection_Homo sapiens_hsa051102.10227087
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.06739646
14N-Glycan biosynthesis_Homo sapiens_hsa005101.88310220
15Chemical carcinogenesis_Homo sapiens_hsa052041.84472262
16One carbon pool by folate_Homo sapiens_hsa006701.82913810
17Selenocompound metabolism_Homo sapiens_hsa004501.81872704
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78493315
19Retinol metabolism_Homo sapiens_hsa008301.70819330
20Arachidonic acid metabolism_Homo sapiens_hsa005901.70210214
21Platelet activation_Homo sapiens_hsa046111.67891570
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63430474
23ECM-receptor interaction_Homo sapiens_hsa045121.63191441
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.60780563
25Cocaine addiction_Homo sapiens_hsa050301.60742613
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54947964
27Arginine biosynthesis_Homo sapiens_hsa002201.52034881
28Olfactory transduction_Homo sapiens_hsa047401.46899194
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46312055
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42254247
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.38426544
32Lysosome_Homo sapiens_hsa041421.36832534
33Fatty acid biosynthesis_Homo sapiens_hsa000611.32086564
34Other glycan degradation_Homo sapiens_hsa005111.27689390
35Glycerolipid metabolism_Homo sapiens_hsa005611.27375135
36Circadian rhythm_Homo sapiens_hsa047101.25836623
37Pancreatic secretion_Homo sapiens_hsa049721.20180733
38PPAR signaling pathway_Homo sapiens_hsa033201.18068509
39Peroxisome_Homo sapiens_hsa041461.16672956
40Ether lipid metabolism_Homo sapiens_hsa005651.13797289
41beta-Alanine metabolism_Homo sapiens_hsa004101.13303786
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11387133
43Salivary secretion_Homo sapiens_hsa049701.11073346
44Amphetamine addiction_Homo sapiens_hsa050311.09194185
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08625524
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07818921
47Taste transduction_Homo sapiens_hsa047421.07229245
48Prolactin signaling pathway_Homo sapiens_hsa049171.07199123
49Tryptophan metabolism_Homo sapiens_hsa003801.04924018
50Insulin resistance_Homo sapiens_hsa049311.04506977
51Complement and coagulation cascades_Homo sapiens_hsa046101.04150084
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03937524
53Sulfur relay system_Homo sapiens_hsa041221.03029387
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01317763
55Glucagon signaling pathway_Homo sapiens_hsa049221.00810672
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00049491
57Phototransduction_Homo sapiens_hsa047440.98934478
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96897248
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95487939
60Regulation of autophagy_Homo sapiens_hsa041400.95069342
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.95010323
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94685198
63Folate biosynthesis_Homo sapiens_hsa007900.93589520
64Galactose metabolism_Homo sapiens_hsa000520.92192976
65Propanoate metabolism_Homo sapiens_hsa006400.89457155
66Thyroid hormone synthesis_Homo sapiens_hsa049180.89351298
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86939539
68Nicotine addiction_Homo sapiens_hsa050330.85176357
69Glutathione metabolism_Homo sapiens_hsa004800.84543770
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83338495
71Bile secretion_Homo sapiens_hsa049760.82100107
72Butanoate metabolism_Homo sapiens_hsa006500.81917573
73ABC transporters_Homo sapiens_hsa020100.81613803
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81372024
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.80420695
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78368553
77Arginine and proline metabolism_Homo sapiens_hsa003300.76080965
78Mineral absorption_Homo sapiens_hsa049780.70494799
79Dopaminergic synapse_Homo sapiens_hsa047280.68019971
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.66421897
81Calcium signaling pathway_Homo sapiens_hsa040200.64992779
82Serotonergic synapse_Homo sapiens_hsa047260.63968390
83Long-term potentiation_Homo sapiens_hsa047200.63457038
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63317725
85Prion diseases_Homo sapiens_hsa050200.63275810
86Sphingolipid metabolism_Homo sapiens_hsa006000.60634130
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60181302
88Estrogen signaling pathway_Homo sapiens_hsa049150.59865340
89Starch and sucrose metabolism_Homo sapiens_hsa005000.59601283
90Collecting duct acid secretion_Homo sapiens_hsa049660.59372687
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58966492
92Cholinergic synapse_Homo sapiens_hsa047250.57314416
93Phenylalanine metabolism_Homo sapiens_hsa003600.57089885
94Linoleic acid metabolism_Homo sapiens_hsa005910.56114593
95Synaptic vesicle cycle_Homo sapiens_hsa047210.56027556
96Circadian entrainment_Homo sapiens_hsa047130.55280464
97Ovarian steroidogenesis_Homo sapiens_hsa049130.55081607
98Histidine metabolism_Homo sapiens_hsa003400.52234457
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51362543
100Long-term depression_Homo sapiens_hsa047300.50676150
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50459838
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49762995
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48911715
104Insulin signaling pathway_Homo sapiens_hsa049100.46817391
105Alcoholism_Homo sapiens_hsa050340.44486621
106Lysine degradation_Homo sapiens_hsa003100.44445982
107GABAergic synapse_Homo sapiens_hsa047270.44156841
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42416295
109Fatty acid metabolism_Homo sapiens_hsa012120.41851466
110Fanconi anemia pathway_Homo sapiens_hsa034600.41712813
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.39830150
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39023762
113Metabolic pathways_Homo sapiens_hsa011000.38280989
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37536156
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35061595
116Antigen processing and presentation_Homo sapiens_hsa046120.34450586
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34375500
118Fat digestion and absorption_Homo sapiens_hsa049750.32751730
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32661455
120mTOR signaling pathway_Homo sapiens_hsa041500.32185618
121Dilated cardiomyopathy_Homo sapiens_hsa054140.31989899
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31500265
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31185422
124Ras signaling pathway_Homo sapiens_hsa040140.30568833
125Thyroid cancer_Homo sapiens_hsa052160.28209285
126Protein digestion and absorption_Homo sapiens_hsa049740.27955116
127Inositol phosphate metabolism_Homo sapiens_hsa005620.26606577
128Tyrosine metabolism_Homo sapiens_hsa003500.26381100
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25803929
130cAMP signaling pathway_Homo sapiens_hsa040240.25539079
131AMPK signaling pathway_Homo sapiens_hsa041520.25203668
132Renin secretion_Homo sapiens_hsa049240.25181075
133Prostate cancer_Homo sapiens_hsa052150.24780215
134Morphine addiction_Homo sapiens_hsa050320.24648843
135Legionellosis_Homo sapiens_hsa051340.23407195
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23275951
137Fatty acid elongation_Homo sapiens_hsa000620.22742541
138Dorso-ventral axis formation_Homo sapiens_hsa043200.21798063
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18356698
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17425133
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16638197
142FoxO signaling pathway_Homo sapiens_hsa040680.15391921
143Bladder cancer_Homo sapiens_hsa052190.12717240
144Phagosome_Homo sapiens_hsa041450.12658509
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12548962
146Fatty acid degradation_Homo sapiens_hsa000710.09508349
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.09057105
148Glutamatergic synapse_Homo sapiens_hsa047240.08640440
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.08172486
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07992214
151Gap junction_Homo sapiens_hsa045400.07070784
152Fructose and mannose metabolism_Homo sapiens_hsa000510.06882717
153Melanogenesis_Homo sapiens_hsa049160.06576376
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.05834936

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