SYTL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.04694766
2COPI coating of Golgi vesicle (GO:0048205)9.04694766
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.88261872
4COPII vesicle coating (GO:0048208)5.87584079
5peptide hormone processing (GO:0016486)5.83298624
6endocrine pancreas development (GO:0031018)5.72312787
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.68948848
8protein retention in ER lumen (GO:0006621)5.13343699
9regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.12602407
10exocrine pancreas development (GO:0031017)4.97172450
11glandular epithelial cell differentiation (GO:0002067)4.93973520
12positive regulation of insulin secretion (GO:0032024)4.93057925
13regulation of cardioblast differentiation (GO:0051890)4.84095971
14positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.65307724
15vesicle coating (GO:0006901)4.43831374
16regulation of type B pancreatic cell apoptotic process (GO:2000674)4.36540028
17L-alpha-amino acid transmembrane transport (GO:1902475)4.36144495
18nucleotide transmembrane transport (GO:1901679)4.19578356
19intestinal epithelial cell development (GO:0060576)4.18151074
20desmosome organization (GO:0002934)4.14802677
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.13682627
22toxin metabolic process (GO:0009404)4.10004131
23insulin secretion (GO:0030073)4.05757367
24positive regulation of vesicle fusion (GO:0031340)4.05022471
25negative regulation of JUN kinase activity (GO:0043508)4.02427029
26positive regulation of peptide hormone secretion (GO:0090277)4.01512286
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.97084522
28sequestering of metal ion (GO:0051238)3.93440234
29regulation of insulin secretion (GO:0050796)3.92140871
30positive regulation of peptide secretion (GO:0002793)3.87484144
31ER overload response (GO:0006983)3.84530716
32positive regulation of amino acid transport (GO:0051957)3.80329763
33embryonic foregut morphogenesis (GO:0048617)3.77706264
34intra-Golgi vesicle-mediated transport (GO:0006891)3.74535175
35retina vasculature morphogenesis in camera-type eye (GO:0061299)3.74244844
36positive regulation of nuclease activity (GO:0032075)3.73418320
37growth hormone secretion (GO:0030252)3.72162228
38signal peptide processing (GO:0006465)3.70792896
39negative regulation of sodium ion transport (GO:0010766)3.68575786
40regulation of glucocorticoid secretion (GO:2000849)3.68001691
41regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.66628113
42gap junction assembly (GO:0016264)3.65380009
43response to hepatocyte growth factor (GO:0035728)3.65295946
44cellular response to hepatocyte growth factor stimulus (GO:0035729)3.65295946
45detection of calcium ion (GO:0005513)3.65169253
46cellular response to vitamin D (GO:0071305)3.61216161
47regulation of peptide hormone secretion (GO:0090276)3.57768882
48branching involved in salivary gland morphogenesis (GO:0060445)3.56932262
49cardiac right ventricle morphogenesis (GO:0003215)3.52732251
50glandular epithelial cell development (GO:0002068)3.51304122
51negative regulation of digestive system process (GO:0060457)3.51117332
52regulation of peptide secretion (GO:0002791)3.50567102
53negative regulation of hormone biosynthetic process (GO:0032353)3.50468194
54regulation of glucocorticoid metabolic process (GO:0031943)3.49698646
55outflow tract septum morphogenesis (GO:0003148)3.48134087
56regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.46068079
57protein maturation by protein folding (GO:0022417)3.44584513
58response to dietary excess (GO:0002021)3.41163546
59regulation of nuclease activity (GO:0032069)3.36164486
60protein autoprocessing (GO:0016540)3.34697382
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34351847
62paraxial mesoderm development (GO:0048339)3.33497538
63cellular zinc ion homeostasis (GO:0006882)3.33478585
64endoplasmic reticulum unfolded protein response (GO:0030968)3.32941375
65peptide hormone secretion (GO:0030072)3.31683544
66cellular response to unfolded protein (GO:0034620)3.30496841
67peptide secretion (GO:0002790)3.27780810
68type B pancreatic cell development (GO:0003323)3.25498968
69regulation of transforming growth factor beta2 production (GO:0032909)3.24708348
70ER-nucleus signaling pathway (GO:0006984)3.21960592
71ER to Golgi vesicle-mediated transport (GO:0006888)3.21910292
72cellular response to topologically incorrect protein (GO:0035967)3.18836085
73regulation of hexokinase activity (GO:1903299)3.18130876
74regulation of glucokinase activity (GO:0033131)3.18130876
75positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.18002198
76vagina development (GO:0060068)3.15391518
77glycine transport (GO:0015816)3.14671499
78positive regulation of growth hormone secretion (GO:0060124)3.13732963
79ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.13450316
80branching involved in mammary gland duct morphogenesis (GO:0060444)3.12823503
81astrocyte differentiation (GO:0048708)3.12430263
82epithelial cell-cell adhesion (GO:0090136)3.12016765
83negative regulation of hormone metabolic process (GO:0032351)3.11927552
84regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.11767674
85prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.11210003
86ventricular cardiac muscle cell development (GO:0055015)3.10812588
87ectodermal placode formation (GO:0060788)3.10015009
883-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.09375552
89purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.09375552
90regulation of hormone secretion (GO:0046883)3.09305806
91apical protein localization (GO:0045176)3.08653610
92cellular response to glucagon stimulus (GO:0071377)3.07224123
93positive regulation of hormone secretion (GO:0046887)3.05853902
94intestinal cholesterol absorption (GO:0030299)3.05799944
95female genitalia development (GO:0030540)3.03441596
96macroautophagy (GO:0016236)3.00610286
97negative regulation of execution phase of apoptosis (GO:1900118)3.00575335
98uterus development (GO:0060065)3.00256258
99regulation of centriole replication (GO:0046599)2.99725639
100establishment of apical/basal cell polarity (GO:0035089)2.99609824
101mesenchyme morphogenesis (GO:0072132)2.99014050
102regulation of calcium ion-dependent exocytosis (GO:0017158)2.97886826
103embryonic camera-type eye morphogenesis (GO:0048596)2.96579968
104response to endoplasmic reticulum stress (GO:0034976)2.96379543
105columnar/cuboidal epithelial cell development (GO:0002066)2.96000102
106negative regulation of striated muscle cell apoptotic process (GO:0010664)2.95007731
107embryonic eye morphogenesis (GO:0048048)2.94734709
108asymmetric protein localization (GO:0008105)2.92639742
109epithelial cell fate commitment (GO:0072148)2.92220716
110hippo signaling (GO:0035329)2.88643138
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88439730
112L-phenylalanine catabolic process (GO:0006559)2.88439730
113regulation of peptide transport (GO:0090087)2.87881235
114embryonic retina morphogenesis in camera-type eye (GO:0060059)2.86452994
115protein N-linked glycosylation via asparagine (GO:0018279)2.86196769
116protein localization to Golgi apparatus (GO:0034067)2.85221428
117regulation of corticosteroid hormone secretion (GO:2000846)2.84654217
118mesenchymal cell proliferation (GO:0010463)2.83639644
119dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83349492
120negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.83004029
121peptidyl-asparagine modification (GO:0018196)2.82275851
122negative regulation of glycoprotein biosynthetic process (GO:0010561)2.81246668
123positive regulation of glycolytic process (GO:0045821)2.79998201
124polarized epithelial cell differentiation (GO:0030859)2.79351977
125zinc ion homeostasis (GO:0055069)2.78200860
126negative regulation of insulin secretion (GO:0046676)2.77583324
127atrial septum morphogenesis (GO:0060413)2.75959599
128adenine nucleotide transport (GO:0051503)2.75361544
129positive regulation of calcium ion import (GO:0090280)2.74877821
130peptide metabolic process (GO:0006518)2.74775315
131Golgi organization (GO:0007030)2.74162592
132hormone secretion (GO:0046879)2.73484399
133regulation of penile erection (GO:0060405)2.72947220
134negative regulation of catecholamine secretion (GO:0033604)2.72882880
135regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.71080315
136purine ribonucleotide transport (GO:0015868)2.71068751
137zinc ion transport (GO:0006829)2.68524749
138regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.68464181
139zinc ion transmembrane transport (GO:0071577)2.67398347
140hormone transport (GO:0009914)2.66800149
141protein N-linked glycosylation (GO:0006487)2.66685338
142positive regulation of astrocyte differentiation (GO:0048711)2.64190531
143hair cell differentiation (GO:0035315)2.61827122
144gastrulation with mouth forming second (GO:0001702)2.58669785
145negative regulation of keratinocyte proliferation (GO:0010839)2.58619391
146epithelial tube branching involved in lung morphogenesis (GO:0060441)2.58123634
147embryonic heart tube development (GO:0035050)2.56707052
148cytoskeletal anchoring at plasma membrane (GO:0007016)2.56161623
149negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.55933947
150innervation (GO:0060384)2.55116008
151branch elongation of an epithelium (GO:0060602)2.53350551
152chondrocyte proliferation (GO:0035988)2.52284779
153morphogenesis of an epithelial sheet (GO:0002011)2.51114229
154axis elongation (GO:0003401)2.48507903
155endocardial cushion morphogenesis (GO:0003203)2.48207101
156regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.45406258
157regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.41082613
158epithelial cell maturation (GO:0002070)2.40155675
159dorsal/ventral axis specification (GO:0009950)2.39862399
160cardiac muscle cell development (GO:0055013)2.39612142
161branching involved in prostate gland morphogenesis (GO:0060442)2.38212736
162regulation of bile acid biosynthetic process (GO:0070857)2.37735269
163cardiac muscle hypertrophy (GO:0003300)2.37711609
164sarcomere organization (GO:0045214)2.37206525
165ear development (GO:0043583)2.34448478
166genitalia development (GO:0048806)2.33150295
167cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.33072000
168endocardial cushion development (GO:0003197)2.32490894
169SMAD protein signal transduction (GO:0060395)2.32048527
170glomerular basement membrane development (GO:0032836)2.31980063
171basement membrane organization (GO:0071711)2.31507374
172establishment or maintenance of monopolar cell polarity (GO:0061339)2.31389456
173establishment of monopolar cell polarity (GO:0061162)2.31389456
174mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.31264362
175ventricular cardiac muscle cell action potential (GO:0086005)2.29654191
176regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.28705669
177negative chemotaxis (GO:0050919)2.28632485
178negative regulation of DNA repair (GO:0045738)2.27641233
179cardiac septum morphogenesis (GO:0060411)2.26800065
180regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26011747
181regulation of steroid hormone biosynthetic process (GO:0090030)2.25939634
182lung lobe morphogenesis (GO:0060463)2.25739242
183negative regulation of skeletal muscle tissue development (GO:0048642)2.25110825
184insulin-like growth factor receptor signaling pathway (GO:0048009)2.25048604
185chondrocyte development (GO:0002063)2.24703265
186endoderm development (GO:0007492)2.24100341
187lung epithelium development (GO:0060428)2.23887483
188notochord development (GO:0030903)2.23308980
189cell communication by electrical coupling (GO:0010644)2.23302957
190negative regulation of homotypic cell-cell adhesion (GO:0034111)2.22691400
191embryonic skeletal joint morphogenesis (GO:0060272)2.20210143
192striated muscle hypertrophy (GO:0014897)2.19884568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.22813780
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.93917796
3ESR1_20079471_ChIP-ChIP_T-47D_Human4.32206548
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.63996714
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.63530955
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.49290468
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.19067148
8ESR1_15608294_ChIP-ChIP_MCF-7_Human3.18223935
9AR_21909140_ChIP-Seq_LNCAP_Human2.93005060
10ZNF263_19887448_ChIP-Seq_K562_Human2.87462382
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.74737306
12AHR_22903824_ChIP-Seq_MCF-7_Human2.70517677
13GBX2_23144817_ChIP-Seq_PC3_Human2.68703364
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.57630727
15GATA1_22025678_ChIP-Seq_K562_Human2.46380465
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.33963927
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.18469523
18FOXM1_26456572_ChIP-Seq_MCF-7_Human2.13073069
19ARNT_22903824_ChIP-Seq_MCF-7_Human2.12247025
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07663852
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04506362
22GATA3_24758297_ChIP-Seq_MCF-7_Human2.02139377
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.93695833
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.85333153
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83966192
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82984045
27IGF1R_20145208_ChIP-Seq_DFB_Human1.79460897
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75416626
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73009323
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72225070
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72067082
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68629968
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68066072
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66376179
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.65802288
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62499619
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61665379
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61622794
39STAT3_23295773_ChIP-Seq_U87_Human1.59400835
40RACK7_27058665_Chip-Seq_MCF-7_Human1.55482858
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51605911
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50500957
43SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49809773
44GATA6_25053715_ChIP-Seq_YYC3_Human1.49292589
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48096736
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46014669
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45937876
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.45881734
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42176247
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41670528
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41305380
52SOX2_20726797_ChIP-Seq_SW620_Human1.38961218
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38326195
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37791229
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36384791
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.36012507
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34803260
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33705386
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33626146
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.33447965
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.31960763
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31131899
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29735299
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.29272269
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.28306897
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.27412111
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26825656
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26722032
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26722032
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25012812
71TCF4_23295773_ChIP-Seq_U87_Human1.24945364
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24807746
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24420851
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24414827
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24336618
76ER_23166858_ChIP-Seq_MCF-7_Human1.24334249
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.24093528
78REST_21632747_ChIP-Seq_MESCs_Mouse1.23924841
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.23381733
80FOXA1_25552417_ChIP-Seq_VCAP_Human1.22485230
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22264819
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22264819
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21762412
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.21608706
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20749076
86* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19533562
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.18893553
88ZNF274_21170338_ChIP-Seq_K562_Hela1.17255398
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17101566
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.15171898
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14769698
92CLOCK_20551151_ChIP-Seq_293T_Human1.14141133
93REST_19997604_ChIP-ChIP_NEURONS_Mouse1.13988692
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13922468
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13052320
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12926026
97BCAT_22108803_ChIP-Seq_LS180_Human1.12884206
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.11656642
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10789245
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10475382
101VDR_22108803_ChIP-Seq_LS180_Human1.10131925
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08891748
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08815564
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08690586
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07795351
106DROSHA_22980978_ChIP-Seq_HELA_Human1.07775857
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07325511
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06971724
109P53_22387025_ChIP-Seq_ESCs_Mouse1.06421144
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06167502
111P300_19829295_ChIP-Seq_ESCs_Human1.05998537
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05044470
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.04134341
114* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04091218
115TP53_18474530_ChIP-ChIP_U2OS_Human1.03585336
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03499681
117REST_18959480_ChIP-ChIP_MESCs_Mouse1.03390377
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03364913
119SOX17_20123909_ChIP-Seq_XEN_Mouse1.03016548
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02760063
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02281817
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02160022
123TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01226850
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01063405
125CHD1_26751641_Chip-Seq_LNCaP_Human1.00791513
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00743430
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00509462
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00450321
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99054911
130CJUN_26792858_Chip-Seq_BT549_Human0.98767347
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.97875141
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97861865
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97540768
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95914098
135RUNX2_22187159_ChIP-Seq_PCA_Human0.95799937
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95431268
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94980711
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94690031
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94519985
140ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94434307
141SOX2_18555785_Chip-Seq_ESCs_Mouse0.94100113
142RARB_27405468_Chip-Seq_BRAIN_Mouse0.93782285
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93216817
144RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93215938
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.91562718
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91274710
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91084640
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90653576
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90644037
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89055108
151NMYC_18555785_Chip-Seq_ESCs_Mouse0.88884138
152GATA4_25053715_ChIP-Seq_YYC3_Human0.88734767
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87275007
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.87225042
155HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87086298
156AR_19668381_ChIP-Seq_PC3_Human0.86951913
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.86791950
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86148209
159FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85861288
160NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85741250
161EOMES_21245162_ChIP-Seq_HESCs_Human0.85067548
162FLI1_21867929_ChIP-Seq_TH2_Mouse0.84781429
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84344692
164PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83984251
165PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83554081
166TCF4_18268006_ChIP-ChIP_LS174T_Human0.83266905
167KDM2B_26808549_Chip-Seq_REH_Human0.82742308
168MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81769585
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.80671672
170ELF5_23300383_ChIP-Seq_T47D_Human0.79088010
171TBX3_20139965_ChIP-Seq_ESCs_Mouse0.78800351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.88030804
2MP0003195_calcinosis4.13559836
3MP0003183_abnormal_peptide_metabolism3.94616819
4MP0010386_abnormal_urinary_bladder3.78271355
5MP0002877_abnormal_melanocyte_morpholog3.73139151
6MP0003941_abnormal_skin_development3.47819594
7MP0002909_abnormal_adrenal_gland3.29214167
8MP0001944_abnormal_pancreas_morphology3.23841812
9MP0004272_abnormal_basement_membrane3.22148453
10MP0005220_abnormal_exocrine_pancreas3.18565843
11MP0009780_abnormal_chondrocyte_physiolo3.16915964
12MP0000003_abnormal_adipose_tissue3.15462563
13MP0002693_abnormal_pancreas_physiology3.10126499
14MP0005379_endocrine/exocrine_gland_phen3.08854118
15MP0004043_abnormal_pH_regulation3.02178098
16MP0000537_abnormal_urethra_morphology2.96445319
17MP0003283_abnormal_digestive_organ2.83328956
18MP0005645_abnormal_hypothalamus_physiol2.83297282
19MP0010678_abnormal_skin_adnexa2.33308019
20MP0000678_abnormal_parathyroid_gland2.30654158
21MP0003122_maternal_imprinting2.18270865
22MP0009053_abnormal_anal_canal2.16695667
23MP0004270_analgesia2.16326828
24MP0002837_dystrophic_cardiac_calcinosis2.14185804
25MP0003705_abnormal_hypodermis_morpholog2.10953841
26MP0009384_cardiac_valve_regurgitation2.04825138
27MP0005248_abnormal_Harderian_gland2.00585298
28MP0006072_abnormal_retinal_apoptosis2.00164662
29MP0010030_abnormal_orbit_morphology2.00049512
30MP0002078_abnormal_glucose_homeostasis1.98085123
31MP0005409_darkened_coat_color1.95162150
32MP0004264_abnormal_extraembryonic_tissu1.92372808
33MP0005365_abnormal_bile_salt1.92239950
34MP0003252_abnormal_bile_duct1.87571022
35MP0004858_abnormal_nervous_system1.82032845
36MP0008438_abnormal_cutaneous_collagen1.74992904
37MP0002697_abnormal_eye_size1.74207524
38MP0000383_abnormal_hair_follicle1.67108442
39MP0001299_abnormal_eye_distance/1.66967198
40MP0000534_abnormal_ureter_morphology1.65645386
41MP0003937_abnormal_limbs/digits/tail_de1.64997267
42MP0003959_abnormal_lean_body1.63447890
43MP0003942_abnormal_urinary_system1.62853404
44MP0003868_abnormal_feces_composition1.61194712
45MP0010352_gastrointestinal_tract_polyps1.59332049
46MP0001765_abnormal_ion_homeostasis1.58107114
47MP0006054_spinal_hemorrhage1.56648395
48MP0003385_abnormal_body_wall1.56570276
49MP0003300_gastrointestinal_ulcer1.55115518
50MP0002928_abnormal_bile_duct1.51362106
51MP0001666_abnormal_nutrient_absorption1.51303427
52MP0003787_abnormal_imprinting1.50479471
53MP0005257_abnormal_intraocular_pressure1.46267049
54MP0002896_abnormal_bone_mineralization1.45248567
55MP0001756_abnormal_urination1.44283826
56MP0002089_abnormal_postnatal_growth/wei1.43054709
57MP0005084_abnormal_gallbladder_morpholo1.42055927
58MP0002098_abnormal_vibrissa_morphology1.39987374
59MP0002638_abnormal_pupillary_reflex1.37101700
60MP0004084_abnormal_cardiac_muscle1.35749706
61MP0002138_abnormal_hepatobiliary_system1.35100839
62MP0002796_impaired_skin_barrier1.34265690
63MP0004233_abnormal_muscle_weight1.34221987
64MP0002084_abnormal_developmental_patter1.31464272
65MP0005076_abnormal_cell_differentiation1.29454458
66MP0003984_embryonic_growth_retardation1.27157136
67MP0002088_abnormal_embryonic_growth/wei1.26525923
68MP0005187_abnormal_penis_morphology1.25207052
69MP0000613_abnormal_salivary_gland1.24789664
70MP0008961_abnormal_basal_metabolism1.21546245
71MP0005375_adipose_tissue_phenotype1.21386091
72MP0004957_abnormal_blastocyst_morpholog1.19496592
73MP0005380_embryogenesis_phenotype1.18724877
74MP0001672_abnormal_embryogenesis/_devel1.18724877
75MP0002822_catalepsy1.17907388
76MP0003953_abnormal_hormone_level1.17533911
77MP0000467_abnormal_esophagus_morphology1.16828419
78MP0009672_abnormal_birth_weight1.16399677
79MP0000427_abnormal_hair_cycle1.11170704
80MP0001849_ear_inflammation1.09995579
81MP0002249_abnormal_larynx_morphology1.09691665
82MP0000627_abnormal_mammary_gland1.08879060
83MP0002234_abnormal_pharynx_morphology1.08488613
84MP0002938_white_spotting1.07623015
85MP0005501_abnormal_skin_physiology1.07055727
86MP0002086_abnormal_extraembryonic_tissu1.06743829
87MP0003115_abnormal_respiratory_system1.04612585
88MP0010234_abnormal_vibrissa_follicle1.04482855
89MP0002163_abnormal_gland_morphology1.03212326
90MP0003936_abnormal_reproductive_system1.02759267
91MP0005636_abnormal_mineral_homeostasis1.00981504
92MP0002139_abnormal_hepatobiliary_system1.00695538
93MP0003123_paternal_imprinting1.00679131
94MP0002085_abnormal_embryonic_tissue1.00629374
95MP0002876_abnormal_thyroid_physiology1.00179449
96MP0005408_hypopigmentation1.00173306
97MP0003935_abnormal_craniofacial_develop0.99606643
98MP0005646_abnormal_pituitary_gland0.99542027
99MP0005058_abnormal_lysosome_morphology0.98878904
100MP0004782_abnormal_surfactant_physiolog0.98558889
101MP0002734_abnormal_mechanical_nocicepti0.97636153
102MP0005085_abnormal_gallbladder_physiolo0.97034923
103MP0000377_abnormal_hair_follicle0.96730774
104MP0000462_abnormal_digestive_system0.96687791
105MP0009643_abnormal_urine_homeostasis0.96331293
106MP0002160_abnormal_reproductive_system0.96024412
107MP0001664_abnormal_digestion0.95625682
108MP0001697_abnormal_embryo_size0.95141899
109MP0000579_abnormal_nail_morphology0.94393700
110MP0009250_abnormal_appendicular_skeleto0.93619212
111MP0001293_anophthalmia0.92939379
112MP0000538_abnormal_urinary_bladder0.92553400
113MP0009703_decreased_birth_body0.92296888
114MP0000631_abnormal_neuroendocrine_gland0.91444916
115MP0004036_abnormal_muscle_relaxation0.91143598
116MP0004019_abnormal_vitamin_homeostasis0.88924042
117MP0008775_abnormal_heart_ventricle0.86766968
118MP0002233_abnormal_nose_morphology0.85931879
119MP0002932_abnormal_joint_morphology0.85521824
120MP0002127_abnormal_cardiovascular_syste0.85414642
121MP0001286_abnormal_eye_development0.85062620
122MP0003453_abnormal_keratinocyte_physiol0.84923303
123MP0000733_abnormal_muscle_development0.84699239
124MP0003121_genomic_imprinting0.84625257
125MP0010630_abnormal_cardiac_muscle0.82392086
126MP0001730_embryonic_growth_arrest0.81836370
127MP0002092_abnormal_eye_morphology0.80303334
128MP0002168_other_aberrant_phenotype0.79825882
129MP0000428_abnormal_craniofacial_morphol0.79515002
130MP0010307_abnormal_tumor_latency0.79432135
131MP0004885_abnormal_endolymph0.79175682
132MP0003890_abnormal_embryonic-extraembry0.79117489
133MP0001270_distended_abdomen0.78079999
134MP0003566_abnormal_cell_adhesion0.77768140
135MP0000639_abnormal_adrenal_gland0.76626355
136MP0003943_abnormal_hepatobiliary_system0.76130216
137MP0003755_abnormal_palate_morphology0.76008922
138MP0005083_abnormal_biliary_tract0.75108150
139MP0000432_abnormal_head_morphology0.74442703
140MP0004197_abnormal_fetal_growth/weight/0.74423363
141MP0000762_abnormal_tongue_morphology0.73382584
142MP0000230_abnormal_systemic_arterial0.73115094
143MP0003172_abnormal_lysosome_physiology0.72653318
144MP0005623_abnormal_meninges_morphology0.72530403
145MP0001986_abnormal_taste_sensitivity0.71986218
146MP0001485_abnormal_pinna_reflex0.71896351
147MP0005448_abnormal_energy_balance0.71796232
148MP0002080_prenatal_lethality0.71161928
149MP0003119_abnormal_digestive_system0.71081579
150MP0002009_preneoplasia0.70551837
151MP0001727_abnormal_embryo_implantation0.67439649
152MP0002925_abnormal_cardiovascular_devel0.67050960
153MP0008932_abnormal_embryonic_tissue0.66472433
154MP0005275_abnormal_skin_tensile0.65922254
155MP0002069_abnormal_eating/drinking_beha0.65057417
156MP0001661_extended_life_span0.64917539
157MP0001188_hyperpigmentation0.64794081
158MP0005332_abnormal_amino_acid0.64536248
159MP0000955_abnormal_spinal_cord0.64228601
160MP0005330_cardiomyopathy0.64029704
161MP0005452_abnormal_adipose_tissue0.63792327
162MP0002751_abnormal_autonomic_nervous0.63401866
163MP0003045_fibrosis0.63236468
164MP0005367_renal/urinary_system_phenotyp0.63138017
165MP0000516_abnormal_urinary_system0.63138017
166MP0002118_abnormal_lipid_homeostasis0.62419147
167MP0005253_abnormal_eye_physiology0.61549903
168MP0002733_abnormal_thermal_nociception0.61288768
169MP0000163_abnormal_cartilage_morphology0.58712702
170MP0002060_abnormal_skin_morphology0.57248570
171MP0002272_abnormal_nervous_system0.56655579
172MP0003633_abnormal_nervous_system0.55623368
173MP0002295_abnormal_pulmonary_circulatio0.55247098
174MP0002557_abnormal_social/conspecific_i0.55192821
175MP0002177_abnormal_outer_ear0.54985119
176MP0003634_abnormal_glial_cell0.53532062
177MP0005310_abnormal_salivary_gland0.51993425

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.05492617
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.84940758
3Hypoglycemic seizures (HP:0002173)6.56070625
4Symptomatic seizures (HP:0011145)5.87502324
5Hypoglycemic coma (HP:0001325)5.66933078
6Hyperglycemia (HP:0003074)5.60827080
7Abnormality of calcium-phosphate metabolism (HP:0100530)4.83217966
8Pancreatic islet-cell hyperplasia (HP:0004510)4.71528048
9Ketoacidosis (HP:0001993)4.52169550
10Abnormality of endocrine pancreas physiology (HP:0012093)4.50894196
11Abnormality of the pancreatic islet cells (HP:0006476)4.50894196
12Large for gestational age (HP:0001520)4.12862632
13Insulin-resistant diabetes mellitus (HP:0000831)4.10921648
14Asymmetry of the thorax (HP:0001555)4.08184137
15Late onset (HP:0003584)3.95667066
16Retinal atrophy (HP:0001105)3.84335614
17J-shaped sella turcica (HP:0002680)3.70803341
18Agitation (HP:0000713)3.62125597
19Microglossia (HP:0000171)3.61481679
20Right ventricular cardiomyopathy (HP:0011663)3.54978492
21Flat acetabular roof (HP:0003180)3.49572636
22Hyperparathyroidism (HP:0000843)3.45895437
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35809984
24Decreased circulating renin level (HP:0003351)3.28517902
25Absent frontal sinuses (HP:0002688)3.08859643
26Abnormality of the distal phalanges of the toes (HP:0010182)2.94865357
27Hypokalemia (HP:0002900)2.89639657
28Dysostosis multiplex (HP:0000943)2.86015912
29Hyperkalemia (HP:0002153)2.84720166
30Spinal cord compression (HP:0002176)2.84615350
31Abnormality of the distal phalanx of the thumb (HP:0009617)2.83125612
32EEG with generalized epileptiform discharges (HP:0011198)2.76976308
33Hypsarrhythmia (HP:0002521)2.76769717
34Menstrual irregularities (HP:0000858)2.75699158
35Conjugated hyperbilirubinemia (HP:0002908)2.74193180
36Ketosis (HP:0001946)2.72083354
37Abnormality of the intrinsic pathway (HP:0010989)2.71603566
38Epileptiform EEG discharges (HP:0011182)2.68942789
39Bilateral microphthalmos (HP:0007633)2.64905937
40Macroorchidism (HP:0000053)2.62696703
41Osteomalacia (HP:0002749)2.62163093
42Abnormal pancreas size (HP:0012094)2.59395461
43Abnormality of potassium homeostasis (HP:0011042)2.58618259
44Abnormality of the umbilical cord (HP:0010881)2.49412102
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.47550685
46Hyperphosphatemia (HP:0002905)2.44541359
47Tracheal stenosis (HP:0002777)2.44494593
48Hypopigmentation of the fundus (HP:0007894)2.44249412
49Congenital sensorineural hearing impairment (HP:0008527)2.41487968
50Mucopolysacchariduria (HP:0008155)2.37483736
51Urinary glycosaminoglycan excretion (HP:0003541)2.37483736
52Long toe (HP:0010511)2.34393207
53Intestinal atresia (HP:0011100)2.33552111
54Myelomeningocele (HP:0002475)2.33409813
55Abnormal umbilical cord blood vessels (HP:0011403)2.33407360
56Single umbilical artery (HP:0001195)2.33407360
57Abnormality of the fetal cardiovascular system (HP:0010948)2.33407360
58Abnormality of renin-angiotensin system (HP:0000847)2.32539285
59Prominent metopic ridge (HP:0005487)2.30586979
60Congenital glaucoma (HP:0001087)2.30050652
61Insulin resistance (HP:0000855)2.29975325
62Micronodular cirrhosis (HP:0001413)2.29650722
63Hypothermia (HP:0002045)2.27733164
64Transposition of the great arteries (HP:0001669)2.27637360
65Abnormal connection of the cardiac segments (HP:0011545)2.27637360
66Abnormal ventriculo-arterial connection (HP:0011563)2.27637360
67Germ cell neoplasia (HP:0100728)2.27628384
68Bifid tongue (HP:0010297)2.27220662
69Absent eyebrow (HP:0002223)2.26388304
70Curly hair (HP:0002212)2.25667218
71Spinal cord lesions (HP:0100561)2.25273105
72Syringomyelia (HP:0003396)2.25273105
73Abnormality of the ischium (HP:0003174)2.24366861
74Proximal tubulopathy (HP:0000114)2.23322151
75Deformed sella turcica (HP:0002681)2.22159214
76Abdominal distention (HP:0003270)2.21640753
77Anal stenosis (HP:0002025)2.21085012
78Bicornuate uterus (HP:0000813)2.21058322
79Breast carcinoma (HP:0003002)2.20662759
80Ectopic anus (HP:0004397)2.19277916
81Sparse lateral eyebrow (HP:0005338)2.18359564
82Distal upper limb amyotrophy (HP:0007149)2.17612136
83Upper limb amyotrophy (HP:0009129)2.17612136
84Abnormality of the phalanges of the hallux (HP:0010057)2.17515468
85Exocrine pancreatic insufficiency (HP:0001738)2.16937116
86Pheochromocytoma (HP:0002666)2.15723002
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.15203075
88Hypoplasia of the fovea (HP:0007750)2.15203075
89Abnormality of chloride homeostasis (HP:0011422)2.14648250
90Aplasia/hypoplasia of the uterus (HP:0008684)2.12148313
91Dysautonomia (HP:0002459)2.12140018
92Midline defect of the nose (HP:0004122)2.11897288
93Chronic bronchitis (HP:0004469)2.10375754
94Cutaneous melanoma (HP:0012056)2.08108327
95Papillary thyroid carcinoma (HP:0002895)2.06284126
96Generalized aminoaciduria (HP:0002909)2.05741014
97Abnormality of polysaccharide metabolism (HP:0011012)2.05497070
98Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05497070
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05497070
100Hemangiomatosis (HP:0007461)2.04987839
101Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.04374089
102Abnormality of the metopic suture (HP:0005556)2.03520057
103Thyroid carcinoma (HP:0002890)2.02982593
104Cortical visual impairment (HP:0100704)2.02931891
105Hypotension (HP:0002615)2.02893078
106Visceral angiomatosis (HP:0100761)2.02458589
107Abnormality of the fovea (HP:0000493)2.01776831
108Hyperactive renin-angiotensin system (HP:0000841)2.00658130
109Hypoplasia of the uterus (HP:0000013)1.98664852
110Ventricular tachycardia (HP:0004756)1.98502163
111Double outlet right ventricle (HP:0001719)1.98277720
112Congenital malformation of the right heart (HP:0011723)1.98277720
113Restlessness (HP:0000711)1.98070931
114Aplasia involving bones of the extremities (HP:0009825)1.96769368
115Aplasia involving bones of the upper limbs (HP:0009823)1.96769368
116Aplasia of the phalanges of the hand (HP:0009802)1.96769368
117Limb hypertonia (HP:0002509)1.96493450
118Flat capital femoral epiphysis (HP:0003370)1.95816956
119Tachypnea (HP:0002789)1.95715515
120Blue irides (HP:0000635)1.95068633
121Skin nodule (HP:0200036)1.94973277
122Premature rupture of membranes (HP:0001788)1.94333903
123Hypoplasia of the iris (HP:0007676)1.93742235
124Neuroendocrine neoplasm (HP:0100634)1.93417822
125Increased circulating renin level (HP:0000848)1.93087549
126Hypophosphatemia (HP:0002148)1.91354093
127Intrahepatic cholestasis (HP:0001406)1.91022806
128Preaxial foot polydactyly (HP:0001841)1.90578944
129Testicular neoplasm (HP:0010788)1.90227211
130Protuberant abdomen (HP:0001538)1.89424309
131Abnormality of the frontal sinuses (HP:0002687)1.87488303
132Distal lower limb muscle weakness (HP:0009053)1.84351092
133Short nail (HP:0001799)1.83768592
134Abnormality of the middle phalanges of the toes (HP:0010183)1.83023720
135Resting tremor (HP:0002322)1.82658024
136Enlarged kidneys (HP:0000105)1.81321738
137Ulnar bowing (HP:0003031)1.81321341
138Abnormality of vitamin metabolism (HP:0100508)1.80397121
139Aplasia of the musculature (HP:0100854)1.80147276
140Hypercortisolism (HP:0001578)1.79012489
141Abnormality of the common coagulation pathway (HP:0010990)1.78579704
142Enlarged penis (HP:0000040)1.78569400
143Abnormal vertebral ossification (HP:0100569)1.78437216
144Progressive sensorineural hearing impairment (HP:0000408)1.78242895
145Short middle phalanx of finger (HP:0005819)1.77720447
146Broad face (HP:0000283)1.76433229
147Growth hormone excess (HP:0000845)1.76394438
148Hand muscle atrophy (HP:0009130)1.75561834
149Orthostatic hypotension (HP:0001278)1.75158748
150Flattened epiphyses (HP:0003071)1.74287204
151Facial cleft (HP:0002006)1.73868776
152Vascular calcification (HP:0004934)1.73242206
153Absent eyelashes (HP:0000561)1.72552930
154Uterine leiomyosarcoma (HP:0002891)1.72195916
155Leiomyosarcoma (HP:0100243)1.72195916
156Hypoplastic left heart (HP:0004383)1.72089054
157Bell-shaped thorax (HP:0001591)1.71831420
158Cystic liver disease (HP:0006706)1.70221766
159Akinesia (HP:0002304)1.70011079
160Irregular vertebral endplates (HP:0003301)1.69808975
161Popliteal pterygium (HP:0009756)1.69590833
162Septate vagina (HP:0001153)1.69173843
163Occipital encephalocele (HP:0002085)1.68791528
164Adrenal overactivity (HP:0002717)1.67335862
165Anxiety (HP:0000739)1.67085156
166Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67006745
167Unilateral renal agenesis (HP:0000122)1.66072912
168Abnormal biliary tract morphology (HP:0012440)1.65185636
169Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65062328
170Mitral stenosis (HP:0001718)1.65048341
171Hypoplastic labia majora (HP:0000059)1.63800216
172Anteriorly placed anus (HP:0001545)1.63640552
173Limited elbow extension (HP:0001377)1.63076444
174Hepatoblastoma (HP:0002884)1.62985087
175Increased CSF protein (HP:0002922)1.61991849
176Limb-girdle muscle atrophy (HP:0003797)1.61914310
177Abnormality of carpal bone ossification (HP:0006257)1.60922075
178Knee flexion contracture (HP:0006380)1.60770173
179Alacrima (HP:0000522)1.59933970
180Type II lissencephaly (HP:0007260)1.59823241
181Vertebral hypoplasia (HP:0008417)1.59714395
182Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.59714395
183Spondylolisthesis (HP:0003302)1.59568952
184Abnormalities of placenta or umbilical cord (HP:0001194)1.58853220
185Bundle branch block (HP:0011710)1.56824252
186Vertebral arch anomaly (HP:0008438)1.56639557
187Neonatal hypoglycemia (HP:0001998)1.56362604
188Morphological abnormality of the middle ear (HP:0008609)1.55997355
189Neonatal short-limb short stature (HP:0008921)1.55742873
190Cardiovascular calcification (HP:0011915)1.55666374
191Broad nasal tip (HP:0000455)1.55214956
192Transitional cell carcinoma of the bladder (HP:0006740)1.54661790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.95861387
2MAPK155.91226345
3PIK3CG4.85073395
4LMTK24.66863784
5INSRR4.17079748
6FRK4.13563851
7TRIB33.29704734
8TAOK33.24384442
9PIK3CA3.20386425
10PKN23.16968082
11PRKD32.54471210
12MAP3K22.47307310
13WNK42.46994305
14UHMK12.39553307
15PASK2.36574730
16RPS6KB22.16730924
17MAP3K122.09771208
18MUSK2.09210787
19EPHA42.08968881
20EIF2AK12.02657877
21HIPK21.94579524
22NME21.88260869
23PAK41.85007813
24AKT31.81044877
25FGFR21.73329636
26CAMKK21.70579085
27SCYL21.64141620
28NTRK11.58159063
29STK38L1.55789341
30PAK31.52293160
31MAP3K91.47946330
32FLT31.40033621
33MST1R1.38702833
34ICK1.38631649
35PHKG11.36147652
36PHKG21.36147652
37EEF2K1.35821329
38SIK11.35592688
39MET1.32172167
40WNK11.31815436
41LATS21.25341776
42FER1.20288461
43PDGFRA1.19453978
44CDC42BPA1.17612528
45STK391.13596673
46PNCK1.13238863
47MAPKAPK31.12347150
48NUAK11.11566852
49FGFR41.05710858
50NTRK31.04570680
51MAP3K11.04105936
52LATS11.01688703
53BCR1.00785304
54PTK21.00714707
55DYRK1B0.98848559
56ILK0.98325040
57ERBB40.97726775
58SMG10.97300363
59STK30.95865194
60ERN10.94348986
61OBSCN0.93663065
62STK380.90340698
63DDR20.89885149
64IRAK10.84441628
65WEE10.83883037
66BRD40.82672017
67EPHA20.81871171
68PTK60.79967988
69FGFR10.79524416
70AKT20.79132497
71OXSR10.77250756
72PRKCH0.75735389
73NEK10.71385249
74TTK0.71326367
75IRAK30.71246090
76CAMK2D0.70491623
77EPHA30.66328237
78MAP3K40.66148779
79FGFR30.65848285
80PBK0.64742358
81PRKD20.64099127
82CDK70.63625038
83TNIK0.62496420
84NEK60.60677775
85PRKCE0.60291955
86BRAF0.59274616
87SGK4940.59259199
88SGK2230.59259199
89TRPM70.58372022
90MAP2K70.56694966
91EIF2AK20.56693185
92DMPK0.53127187
93PLK40.52703672
94CSNK1A1L0.49782399
95SRPK10.49538833
96MELK0.48509354
97PDPK10.48053916
98RET0.48028848
99TAOK10.47108832
100STK240.47107827
101CAMK2B0.46003706
102MAP2K40.45222990
103CAMKK10.45169426
104TESK10.44981226
105MARK20.44683107
106KSR10.43018116
107NEK20.42138308
108EPHB10.41858304
109PDGFRB0.41786335
110PAK20.41551935
111MYLK0.40369702
112MAP2K10.40342631
113CASK0.40180367
114CDK60.39974428
115CDK50.39659086
116ACVR1B0.38952834
117TTN0.37580912
118SGK20.37362588
119RPS6KB10.36311979
120MTOR0.36288037
121BRSK20.36109570
122SGK30.35613748
123CSNK1A10.35119829
124CAMK1G0.34973608
125LIMK10.34900077
126LRRK20.34875634
127RIPK10.34475564
128BMPR1B0.34239318
129CSNK1G10.32229861
130CSNK1G30.32187917
131CAMK1D0.31798286
132CSNK1G20.31771727
133ERBB30.31470953
134TYRO30.29867585
135BRSK10.28739439
136MAP2K20.28541654
137SGK10.27864938
138PRKD10.26935447
139ADRBK10.25684301
140PLK10.25193521
141KSR20.24896373
142MAPK100.24688897
143AURKB0.24433381
144CHUK0.24404680
145GSK3A0.24251629
146ROCK10.24164846
147CAMK2G0.23204754
148PRKAA10.22850228
149NEK90.22844012
150RPS6KA20.22752380
151RPS6KA30.22611791
152PRKCI0.22350007
153EIF2AK30.21985814
154PRKG10.20518351
155PAK60.20253727
156PRKACA0.20197975
157IGF1R0.19601034
158BMPR20.18875092
159INSR0.18245915
160PRKACG0.17322222
161PRKDC0.16854410
162PRKCA0.16756091
163CAMK2A0.16106435

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.29735576
2Protein export_Homo sapiens_hsa030604.97771000
3Insulin secretion_Homo sapiens_hsa049113.22893015
4Sulfur metabolism_Homo sapiens_hsa009203.03204327
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.99516924
6Type I diabetes mellitus_Homo sapiens_hsa049402.53668906
7Thyroid cancer_Homo sapiens_hsa052162.33905085
8Vibrio cholerae infection_Homo sapiens_hsa051102.22591394
9Type II diabetes mellitus_Homo sapiens_hsa049302.03793156
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96299868
11ECM-receptor interaction_Homo sapiens_hsa045121.85154350
12TGF-beta signaling pathway_Homo sapiens_hsa043501.79726334
13Hippo signaling pathway_Homo sapiens_hsa043901.67015127
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.65256494
15Endometrial cancer_Homo sapiens_hsa052131.57627276
16Pancreatic secretion_Homo sapiens_hsa049721.56842887
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.56461337
18Small cell lung cancer_Homo sapiens_hsa052221.55533745
19Cocaine addiction_Homo sapiens_hsa050301.54395297
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47299343
21Dilated cardiomyopathy_Homo sapiens_hsa054141.47026355
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41569902
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38692193
24N-Glycan biosynthesis_Homo sapiens_hsa005101.36662840
25Butanoate metabolism_Homo sapiens_hsa006501.35924253
26Adherens junction_Homo sapiens_hsa045201.30601263
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30495757
28Focal adhesion_Homo sapiens_hsa045101.30411675
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29269982
30mTOR signaling pathway_Homo sapiens_hsa041501.27370045
31Amphetamine addiction_Homo sapiens_hsa050311.26874949
32Lysosome_Homo sapiens_hsa041421.24422091
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17789799
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17305578
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15602362
36Glucagon signaling pathway_Homo sapiens_hsa049221.15145862
37Glioma_Homo sapiens_hsa052141.12447964
38Circadian rhythm_Homo sapiens_hsa047101.12088592
39Proteoglycans in cancer_Homo sapiens_hsa052051.09677787
40GABAergic synapse_Homo sapiens_hsa047271.08934508
41Thyroid hormone synthesis_Homo sapiens_hsa049181.08564944
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07127892
43Vitamin B6 metabolism_Homo sapiens_hsa007501.04466502
44Regulation of autophagy_Homo sapiens_hsa041401.04465339
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03241057
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01008479
47ABC transporters_Homo sapiens_hsa020101.00080619
48Other glycan degradation_Homo sapiens_hsa005110.99049984
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98688053
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95666644
51Choline metabolism in cancer_Homo sapiens_hsa052310.94810514
52Renal cell carcinoma_Homo sapiens_hsa052110.94383996
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.94218650
54Hedgehog signaling pathway_Homo sapiens_hsa043400.94065956
55Amoebiasis_Homo sapiens_hsa051460.93629438
56Dopaminergic synapse_Homo sapiens_hsa047280.91025753
57Protein digestion and absorption_Homo sapiens_hsa049740.90998780
58Basal cell carcinoma_Homo sapiens_hsa052170.90997757
59Synaptic vesicle cycle_Homo sapiens_hsa047210.90728092
60Taste transduction_Homo sapiens_hsa047420.89708169
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87332183
62Arginine biosynthesis_Homo sapiens_hsa002200.86047148
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.85558738
64Selenocompound metabolism_Homo sapiens_hsa004500.85312670
65Non-homologous end-joining_Homo sapiens_hsa034500.85219734
66Fat digestion and absorption_Homo sapiens_hsa049750.84729407
67Non-small cell lung cancer_Homo sapiens_hsa052230.84721972
68Folate biosynthesis_Homo sapiens_hsa007900.82846053
69MicroRNAs in cancer_Homo sapiens_hsa052060.82678329
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.82481922
71Circadian entrainment_Homo sapiens_hsa047130.82418120
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82001772
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81146318
74Sulfur relay system_Homo sapiens_hsa041220.80863164
75Prion diseases_Homo sapiens_hsa050200.80584470
76Melanoma_Homo sapiens_hsa052180.79848950
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79120798
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78034886
79Chronic myeloid leukemia_Homo sapiens_hsa052200.77281144
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75712067
81Vitamin digestion and absorption_Homo sapiens_hsa049770.75498635
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74868278
83Sphingolipid metabolism_Homo sapiens_hsa006000.74593170
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74564466
85Galactose metabolism_Homo sapiens_hsa000520.72018042
86Serotonergic synapse_Homo sapiens_hsa047260.71711865
87Phenylalanine metabolism_Homo sapiens_hsa003600.71245453
88p53 signaling pathway_Homo sapiens_hsa041150.69844894
89Axon guidance_Homo sapiens_hsa043600.69252068
90Cholinergic synapse_Homo sapiens_hsa047250.68272780
91Tryptophan metabolism_Homo sapiens_hsa003800.68059932
92Linoleic acid metabolism_Homo sapiens_hsa005910.66204706
93Collecting duct acid secretion_Homo sapiens_hsa049660.65440586
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63224618
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63219669
96Long-term potentiation_Homo sapiens_hsa047200.62268069
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61967742
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61840223
99Renin secretion_Homo sapiens_hsa049240.61257962
100Ether lipid metabolism_Homo sapiens_hsa005650.60816593
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60729344
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60057563
103Starch and sucrose metabolism_Homo sapiens_hsa005000.58983320
104mRNA surveillance pathway_Homo sapiens_hsa030150.58216460
105Estrogen signaling pathway_Homo sapiens_hsa049150.57488568
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56693503
107Morphine addiction_Homo sapiens_hsa050320.55738719
108Long-term depression_Homo sapiens_hsa047300.55544153
109Fructose and mannose metabolism_Homo sapiens_hsa000510.54165879
110Steroid biosynthesis_Homo sapiens_hsa001000.53815936
111RNA transport_Homo sapiens_hsa030130.53481443
112beta-Alanine metabolism_Homo sapiens_hsa004100.53442481
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52444549
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.52285862
115Melanogenesis_Homo sapiens_hsa049160.52220547
116Bile secretion_Homo sapiens_hsa049760.52132546
117Wnt signaling pathway_Homo sapiens_hsa043100.51832643
118Inositol phosphate metabolism_Homo sapiens_hsa005620.51745451
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51510471
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50849435
121cAMP signaling pathway_Homo sapiens_hsa040240.50766077
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49536829
123Carbon metabolism_Homo sapiens_hsa012000.49082597
124Pyruvate metabolism_Homo sapiens_hsa006200.48369718
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.47954858
126Mineral absorption_Homo sapiens_hsa049780.47054944
127Propanoate metabolism_Homo sapiens_hsa006400.46901653
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46900637
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46815760
130Phagosome_Homo sapiens_hsa041450.46797477
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46230495
132Ovarian steroidogenesis_Homo sapiens_hsa049130.46129167
133Prolactin signaling pathway_Homo sapiens_hsa049170.46030061
134Pathways in cancer_Homo sapiens_hsa052000.45633065
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42404105
136Insulin resistance_Homo sapiens_hsa049310.41612430
137Peroxisome_Homo sapiens_hsa041460.39926423
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39880053
139Fatty acid elongation_Homo sapiens_hsa000620.36790352
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36626590
141Renin-angiotensin system_Homo sapiens_hsa046140.34715389
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34158526
143Insulin signaling pathway_Homo sapiens_hsa049100.33756413
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.33490798
145Tight junction_Homo sapiens_hsa045300.32110223
146Alcoholism_Homo sapiens_hsa050340.31896820
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30493883
148Gastric acid secretion_Homo sapiens_hsa049710.30112844
149Prostate cancer_Homo sapiens_hsa052150.29653664
150Glutamatergic synapse_Homo sapiens_hsa047240.29199850
151Histidine metabolism_Homo sapiens_hsa003400.28817575
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28661904
153Gap junction_Homo sapiens_hsa045400.28607373
154Fatty acid degradation_Homo sapiens_hsa000710.27605703
155GnRH signaling pathway_Homo sapiens_hsa049120.25649628
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24306653
157AMPK signaling pathway_Homo sapiens_hsa041520.23537410
158Lysine degradation_Homo sapiens_hsa003100.22499928
159Bladder cancer_Homo sapiens_hsa052190.22050409
160Salivary secretion_Homo sapiens_hsa049700.21094507
161ErbB signaling pathway_Homo sapiens_hsa040120.20882267

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