SZRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.58143636
2Golgi transport vesicle coating (GO:0048200)4.58143636
3protein localization to endosome (GO:0036010)4.07203708
4negative regulation of erythrocyte differentiation (GO:0045647)3.88665404
5pinocytosis (GO:0006907)3.57062376
6barbed-end actin filament capping (GO:0051016)3.53945291
7regulation of early endosome to late endosome transport (GO:2000641)3.41267113
8glycine metabolic process (GO:0006544)3.39847591
9folic acid-containing compound biosynthetic process (GO:0009396)3.38305783
10maternal placenta development (GO:0001893)3.31609619
11lysine metabolic process (GO:0006553)3.29506955
12lysine catabolic process (GO:0006554)3.29506955
13stress fiber assembly (GO:0043149)3.27478229
14regulation of cholesterol homeostasis (GO:2000188)3.25669691
15negative regulation of fibrinolysis (GO:0051918)3.22740981
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16499495
17adherens junction assembly (GO:0034333)3.14262766
18protein retention in ER lumen (GO:0006621)3.12616423
19focal adhesion assembly (GO:0048041)3.12300469
20cell-substrate adherens junction assembly (GO:0007045)3.12300469
21L-phenylalanine metabolic process (GO:0006558)3.11906646
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.11906646
23low-density lipoprotein particle clearance (GO:0034383)3.06431918
24alpha-linolenic acid metabolic process (GO:0036109)3.02613729
25modulation by symbiont of host cellular process (GO:0044068)3.02014141
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00347321
27sulfur amino acid catabolic process (GO:0000098)2.93760038
28glyoxylate metabolic process (GO:0046487)2.93740589
29kynurenine metabolic process (GO:0070189)2.89880720
304-hydroxyproline metabolic process (GO:0019471)2.89211477
31cell-substrate junction assembly (GO:0007044)2.88718432
32regulation of fatty acid beta-oxidation (GO:0031998)2.87881438
33negative regulation of cholesterol transport (GO:0032375)2.87162881
34negative regulation of sterol transport (GO:0032372)2.87162881
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.84576987
36serine family amino acid catabolic process (GO:0009071)2.84001716
37pentose-phosphate shunt (GO:0006098)2.82902982
38regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82891836
39protein carboxylation (GO:0018214)2.81393127
40peptidyl-glutamic acid carboxylation (GO:0017187)2.81393127
41NIK/NF-kappaB signaling (GO:0038061)2.80097826
42positive regulation of fatty acid beta-oxidation (GO:0032000)2.80083693
43negative regulation of cell size (GO:0045792)2.79760497
44viral transcription (GO:0019083)2.78816671
45embryonic process involved in female pregnancy (GO:0060136)2.78079018
46positive regulation of Cdc42 GTPase activity (GO:0043089)2.77762028
47serine family amino acid biosynthetic process (GO:0009070)2.76237239
48cysteine metabolic process (GO:0006534)2.76002327
49L-phenylalanine catabolic process (GO:0006559)2.75698459
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.75698459
51mannose metabolic process (GO:0006013)2.75382317
522-oxoglutarate metabolic process (GO:0006103)2.73770544
53serine family amino acid metabolic process (GO:0009069)2.72428594
54regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69346959
55positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69333699
56basement membrane organization (GO:0071711)2.68938249
57regulation of glucose import in response to insulin stimulus (GO:2001273)2.66187664
58translational termination (GO:0006415)2.66010739
59regulation of cholesterol storage (GO:0010885)2.64207421
60modulation by virus of host process (GO:0019054)2.63289922
61plasma lipoprotein particle clearance (GO:0034381)2.63251770
62regulation of translational fidelity (GO:0006450)2.63013937
63folic acid metabolic process (GO:0046655)2.61629284
64tetrahydrofolate metabolic process (GO:0046653)2.59579986
65regulation of fibrinolysis (GO:0051917)2.57586018
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57192328
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57192328
68positive regulation of histone deacetylation (GO:0031065)2.57051265
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56975566
70urea cycle (GO:0000050)2.56942751
71urea metabolic process (GO:0019627)2.56942751
72amino-acid betaine metabolic process (GO:0006577)2.55695956
73NADPH regeneration (GO:0006740)2.55447864
74activation of Rac GTPase activity (GO:0032863)2.55276523
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.54516303
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54294304
77homocysteine metabolic process (GO:0050667)2.53619121
78positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53388448
79negative regulation of fatty acid biosynthetic process (GO:0045717)2.52416548
80valine metabolic process (GO:0006573)2.52104425
81activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51911293
82planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51550552
83apoptotic process involved in morphogenesis (GO:0060561)2.51295699
84aromatic amino acid family catabolic process (GO:0009074)2.50115072
85heterochromatin organization (GO:0070828)2.49818044
86complement activation, alternative pathway (GO:0006957)2.49296062
87ethanol oxidation (GO:0006069)2.48875483
88mitotic chromosome condensation (GO:0007076)2.48822799
89proline biosynthetic process (GO:0006561)2.47985918
90translational elongation (GO:0006414)2.46960721
91regulation of extracellular matrix disassembly (GO:0010715)2.46193511
92DNA unwinding involved in DNA replication (GO:0006268)2.45628607
93regulation of protein activation cascade (GO:2000257)2.44696289
94positive regulation of nuclease activity (GO:0032075)2.44336603
95response to peptidoglycan (GO:0032494)2.43407860
96activation of MAPKKK activity (GO:0000185)2.43086911
97hypotonic response (GO:0006971)2.43056822
98epithelial cell-cell adhesion (GO:0090136)2.42286736
99apoptotic cell clearance (GO:0043277)2.42234373
100cellular response to virus (GO:0098586)2.41939059
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41692972
102positive regulation by organism of defense response of other organism involved in symbiotic interact2.41692972
103modulation by symbiont of host immune response (GO:0052553)2.41692972
104positive regulation by symbiont of host defense response (GO:0052509)2.41692972
105modulation by symbiont of host defense response (GO:0052031)2.41692972
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41692972
107epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41488802
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.40123008
109tricarboxylic acid metabolic process (GO:0072350)2.39737334
110nitrogen cycle metabolic process (GO:0071941)2.38144301
111regulation of NFAT protein import into nucleus (GO:0051532)2.37534683
112response to laminar fluid shear stress (GO:0034616)2.37522358
113negative regulation of lipid transport (GO:0032369)2.36415140
114negative regulation of necroptotic process (GO:0060546)2.36003944
115vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.35431517
116regulation of complement activation (GO:0030449)2.35300328
117hyaluronan catabolic process (GO:0030214)2.35197109
118positive regulation of extracellular matrix organization (GO:1903055)2.34689308
119glucose catabolic process (GO:0006007)2.34546980
120cortical actin cytoskeleton organization (GO:0030866)2.34236744
121positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.33608843
122regulation of defense response to virus by virus (GO:0050690)2.32921330
123endoplasmic reticulum unfolded protein response (GO:0030968)2.32728419
124regulation of apoptotic process involved in morphogenesis (GO:1902337)2.32623406
125acetyl-CoA metabolic process (GO:0006084)2.32500697
126modulation by virus of host morphology or physiology (GO:0019048)2.32374159
127protein maturation by protein folding (GO:0022417)2.32014411
128membrane raft organization (GO:0031579)2.31815869
129regulation of hippo signaling (GO:0035330)2.31511361
130L-serine metabolic process (GO:0006563)2.31330798
131positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.31103290
132regulation of SMAD protein import into nucleus (GO:0060390)2.30870252
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30407380
134positive regulation of receptor recycling (GO:0001921)2.30404762
135positive regulation of myotube differentiation (GO:0010831)2.29992764
136endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.29571751
137positive regulation of triglyceride biosynthetic process (GO:0010867)2.29551456
138negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.28878983
139T cell apoptotic process (GO:0070231)2.28622011
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.28615940
141regulation of translational termination (GO:0006449)2.28225528
142antigen processing and presentation of endogenous antigen (GO:0019883)2.27695986
143tryptophan catabolic process (GO:0006569)2.27139532
144indole-containing compound catabolic process (GO:0042436)2.27139532
145indolalkylamine catabolic process (GO:0046218)2.27139532
146translational initiation (GO:0006413)2.26258970
147positive regulation of triglyceride metabolic process (GO:0090208)2.25842100
148negative regulation of viral release from host cell (GO:1902187)2.25521897
149response to muramyl dipeptide (GO:0032495)2.25080282
150positive regulation of lipid storage (GO:0010884)2.23676094
151cellular modified amino acid catabolic process (GO:0042219)2.23074198
152nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.22977937
153regulation of nuclease activity (GO:0032069)2.22522195
154negative regulation of fatty acid transport (GO:2000192)2.22376415
155folic acid-containing compound metabolic process (GO:0006760)2.22363583
156formation of translation preinitiation complex (GO:0001731)2.21891014
157ER-nucleus signaling pathway (GO:0006984)2.21381600
158regulation of triglyceride catabolic process (GO:0010896)2.21117934
159regulation of histone H3-K27 methylation (GO:0061085)2.20637833
160regulation of integrin activation (GO:0033623)2.20501848
161spliceosomal tri-snRNP complex assembly (GO:0000244)2.20211220
1623-UTR-mediated mRNA stabilization (GO:0070935)2.18860139
163protein-lipid complex assembly (GO:0065005)2.18625880
164tryptophan metabolic process (GO:0006568)2.18554475
165RNA stabilization (GO:0043489)2.18436802
166mRNA stabilization (GO:0048255)2.18436802
167negative regulation of skeletal muscle tissue development (GO:0048642)2.18284421
168regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.17507726
169aspartate family amino acid catabolic process (GO:0009068)2.17487989
170one-carbon metabolic process (GO:0006730)2.17391995
171skin morphogenesis (GO:0043589)2.16594750
172protein localization to kinetochore (GO:0034501)2.16167327
173cellular protein complex localization (GO:0034629)2.15615218
174membrane protein ectodomain proteolysis (GO:0006509)2.14691874
175regulation of gamma-delta T cell differentiation (GO:0045586)2.14589282
176intracellular estrogen receptor signaling pathway (GO:0030520)2.14125557
177phospholipid homeostasis (GO:0055091)2.13899216
178regulation of necroptotic process (GO:0060544)2.13112389
179bile acid biosynthetic process (GO:0006699)2.13000816
180negative regulation of fatty acid metabolic process (GO:0045922)2.12990867
181cellular response to unfolded protein (GO:0034620)2.12382308
182negative regulation of homotypic cell-cell adhesion (GO:0034111)2.10890177
183adhesion of symbiont to host (GO:0044406)2.09020538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.90624380
2E2F7_22180533_ChIP-Seq_HELA_Human3.58822850
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.98092764
4PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77248038
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72108741
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.70513828
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.68137157
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63862989
9MYC_22102868_ChIP-Seq_BL_Human2.62476239
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.55707577
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.26262204
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.01557375
13LXR_22158963_ChIP-Seq_LIVER_Mouse1.99550602
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97760174
15VDR_21846776_ChIP-Seq_THP-1_Human1.97064305
16CLOCK_20551151_ChIP-Seq_293T_Human1.95802160
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91607070
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84086994
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.78946478
20ZNF263_19887448_ChIP-Seq_K562_Human1.76609612
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.73423647
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65865081
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64206832
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62364588
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54193489
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52564481
27TCF7_22412390_ChIP-Seq_EML_Mouse1.50860268
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46328273
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46076834
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45618187
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45600692
32MAF_26560356_Chip-Seq_TH1_Human1.41541807
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39347863
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.38792679
35LXR_22292898_ChIP-Seq_THP-1_Human1.38569799
36ATF3_27146783_Chip-Seq_COLON_Human1.38507041
37KDM2B_26808549_Chip-Seq_DND41_Human1.38414808
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38325842
39RACK7_27058665_Chip-Seq_MCF-7_Human1.38227991
40AR_21909140_ChIP-Seq_LNCAP_Human1.34391257
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34089797
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33120566
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31366528
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30828473
45UTX_26944678_Chip-Seq_JUKART_Human1.30561482
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30372843
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29158811
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28898840
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27979311
50XRN2_22483619_ChIP-Seq_HELA_Human1.27733410
51KDM2B_26808549_Chip-Seq_K562_Human1.27693165
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.26972004
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26913483
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25788523
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25703404
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25015697
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24516631
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.23698870
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23462382
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22796099
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22027494
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20916327
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19293446
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19000436
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18344806
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17369226
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17092103
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.16759173
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16652573
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16307732
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15416926
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14995486
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14668265
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14439111
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14130984
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13542205
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.13363338
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12467150
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12229091
80NCOR1_26117541_ChIP-Seq_K562_Human1.11872697
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10177837
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08942286
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.08827592
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07794023
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07432632
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.07328930
87MAF_26560356_Chip-Seq_TH2_Human1.07255155
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06971609
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06652133
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06476758
91TP53_22127205_ChIP-Seq_IMR90_Human1.05783026
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05400418
93P68_20966046_ChIP-Seq_HELA_Human1.05143346
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05089713
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04697533
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04553401
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04544913
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03554107
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03402963
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02664300
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.01093336
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00830272
103VDR_24763502_ChIP-Seq_THP-1_Human1.00639659
104KDM5A_27292631_Chip-Seq_BREAST_Human0.98784048
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97064489
106* CIITA_25753668_ChIP-Seq_RAJI_Human0.96871490
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96767305
108GATA6_25053715_ChIP-Seq_YYC3_Human0.95971371
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95426766
110CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95400941
111CREB1_26743006_Chip-Seq_LNCaP_Human0.95232634
112SPI1_23127762_ChIP-Seq_K562_Human0.95158543
113SMC4_20622854_ChIP-Seq_HELA_Human0.94772436
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94398774
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94020374
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93623487
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93319644
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93034834
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92151456
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91987543
121TFEB_21752829_ChIP-Seq_HELA_Human0.91249244
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90548208
123CHD1_26751641_Chip-Seq_LNCaP_Human0.89705936
124MYB_26560356_Chip-Seq_TH1_Human0.89675456
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89460550
126NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88795417
127ETS1_20019798_ChIP-Seq_JURKAT_Human0.88659756
128E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87433480
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87315765
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87143719
131CTCF_21964334_Chip-Seq_Bcells_Human0.86554054
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86268342
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86082485
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85445571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.63958680
2MP0002139_abnormal_hepatobiliary_system3.04966850
3MP0005360_urolithiasis3.00622687
4MP0009840_abnormal_foam_cell2.66534236
5MP0010352_gastrointestinal_tract_polyps2.16471518
6MP0005365_abnormal_bile_salt2.09713408
7MP0003806_abnormal_nucleotide_metabolis2.04589514
8MP0005085_abnormal_gallbladder_physiolo2.01057161
9MP0008438_abnormal_cutaneous_collagen1.95187814
10MP0003566_abnormal_cell_adhesion1.83365949
11MP0005076_abnormal_cell_differentiation1.66800302
12MP0003300_gastrointestinal_ulcer1.65706302
13MP0008260_abnormal_autophagy1.60750272
14MP0003303_peritoneal_inflammation1.58996140
15MP0003191_abnormal_cellular_cholesterol1.57809559
16MP0004233_abnormal_muscle_weight1.57396400
17MP0003252_abnormal_bile_duct1.55830232
18MP0004858_abnormal_nervous_system1.49733246
19MP0005623_abnormal_meninges_morphology1.49269356
20MP0009053_abnormal_anal_canal1.48192603
21MP0005023_abnormal_wound_healing1.45411951
22MP0005083_abnormal_biliary_tract1.45074652
23MP0010329_abnormal_lipoprotein_level1.42922413
24MP0004185_abnormal_adipocyte_glucose1.42593432
25MP0004510_myositis1.40038773
26MP0000609_abnormal_liver_physiology1.37134953
27MP0003763_abnormal_thymus_physiology1.36396731
28MP0006054_spinal_hemorrhage1.34222911
29MP0009278_abnormal_bone_marrow1.33303099
30MP0008875_abnormal_xenobiotic_pharmacok1.30334941
31MP0000733_abnormal_muscle_development1.26283176
32MP0005464_abnormal_platelet_physiology1.25505419
33MP0000750_abnormal_muscle_regeneration1.22920020
34MP0001533_abnormal_skeleton_physiology1.20404755
35MP0004957_abnormal_blastocyst_morpholog1.19932853
36MP0005666_abnormal_adipose_tissue1.19647943
37MP0002998_abnormal_bone_remodeling1.19476696
38MP0003693_abnormal_embryo_hatching1.19185200
39MP0005275_abnormal_skin_tensile1.18835895
40MP0000751_myopathy1.18641093
41MP0001348_abnormal_lacrimal_gland1.17301838
42MP0001849_ear_inflammation1.16921336
43MP0001835_abnormal_antigen_presentation1.16876708
44MP0005000_abnormal_immune_tolerance1.16029842
45MP0003828_pulmonary_edema1.15751926
46MP0005409_darkened_coat_color1.14490959
47MP0001730_embryonic_growth_arrest1.12787288
48MP0003436_decreased_susceptibility_to1.12153889
49MP0010307_abnormal_tumor_latency1.11243104
50MP0005332_abnormal_amino_acid1.10542641
51MP0002419_abnormal_innate_immunity1.08146901
52MP0000490_abnormal_crypts_of1.07800953
53MP0005319_abnormal_enzyme/_coenzyme1.07598551
54MP0000678_abnormal_parathyroid_gland1.07200132
55MP0002877_abnormal_melanocyte_morpholog1.06705356
56MP0005025_abnormal_response_to1.05923969
57MP0003453_abnormal_keratinocyte_physiol1.05547743
58MP0005387_immune_system_phenotype1.03547895
59MP0001790_abnormal_immune_system1.03547895
60MP0000598_abnormal_liver_morphology1.03495570
61MP0004197_abnormal_fetal_growth/weight/1.02051883
62MP0004947_skin_inflammation1.01670360
63MP0010234_abnormal_vibrissa_follicle1.01474255
64MP0009643_abnormal_urine_homeostasis0.99983707
65MP0001666_abnormal_nutrient_absorption0.99877125
66MP0000759_abnormal_skeletal_muscle0.98363104
67MP0003111_abnormal_nucleus_morphology0.97662607
68MP0002088_abnormal_embryonic_growth/wei0.96763423
69MP0010630_abnormal_cardiac_muscle0.96002809
70MP0003984_embryonic_growth_retardation0.95768752
71MP0005621_abnormal_cell_physiology0.95515336
72MP0000685_abnormal_immune_system0.94860505
73MP0002138_abnormal_hepatobiliary_system0.93771712
74MP0002089_abnormal_postnatal_growth/wei0.93340954
75MP0000343_altered_response_to0.93320091
76MP0010030_abnormal_orbit_morphology0.92977993
77MP0002086_abnormal_extraembryonic_tissu0.92856135
78MP0010368_abnormal_lymphatic_system0.91802006
79MP0003077_abnormal_cell_cycle0.91362344
80MP0001672_abnormal_embryogenesis/_devel0.91252937
81MP0005380_embryogenesis_phenotype0.91252937
82MP0003172_abnormal_lysosome_physiology0.91012933
83MP0001915_intracranial_hemorrhage0.90817419
84MP0000003_abnormal_adipose_tissue0.90553512
85MP0003567_abnormal_fetal_cardiomyocyte0.90386125
86MP0003279_aneurysm0.90379070
87MP0004087_abnormal_muscle_fiber0.90332612
88MP0002060_abnormal_skin_morphology0.90242384
89MP0002452_abnormal_antigen_presenting0.89771022
90MP0005390_skeleton_phenotype0.89122931
91MP0002398_abnormal_bone_marrow0.88832440
92MP0004084_abnormal_cardiac_muscle0.87802533
93MP0005257_abnormal_intraocular_pressure0.86988833
94MP0004019_abnormal_vitamin_homeostasis0.86977969
95MP0005058_abnormal_lysosome_morphology0.86323418
96MP0002420_abnormal_adaptive_immunity0.86138468
97MP0000747_muscle_weakness0.85932150
98MP0001819_abnormal_immune_cell0.85806686
99MP0002723_abnormal_immune_serum0.85066579
100MP0005503_abnormal_tendon_morphology0.84891015
101MP0001216_abnormal_epidermal_layer0.83493283
102MP0001243_abnormal_dermal_layer0.83403409
103MP0005375_adipose_tissue_phenotype0.82985319
104MP0002896_abnormal_bone_mineralization0.82735858
105MP0005670_abnormal_white_adipose0.82610837
106MP0009785_altered_susceptibility_to0.82471106
107MP0003075_altered_response_to0.82429875
108MP0000350_abnormal_cell_proliferation0.82199863
109MP0002148_abnormal_hypersensitivity_rea0.82159174
110MP0002269_muscular_atrophy0.81394926
111MP0002796_impaired_skin_barrier0.81075445
112MP0001873_stomach_inflammation0.80949943
113MP0004130_abnormal_muscle_cell0.80904395
114MP0005330_cardiomyopathy0.79979345
115MP0000858_altered_metastatic_potential0.79774100
116MP0001697_abnormal_embryo_size0.79642923
117MP0000703_abnormal_thymus_morphology0.79465254
118MP0002166_altered_tumor_susceptibility0.78660002
119MP0002405_respiratory_system_inflammati0.77964807
120MP0003221_abnormal_cardiomyocyte_apopto0.77449678
121MP0009333_abnormal_splenocyte_physiolog0.77378874
122MP0002429_abnormal_blood_cell0.77241449
123MP0002080_prenatal_lethality0.76994430
124MP0001542_abnormal_bone_strength0.76293782
125MP0009672_abnormal_birth_weight0.75139970
126MP0000716_abnormal_immune_system0.74111688
127MP0002118_abnormal_lipid_homeostasis0.73843395
128MP0004808_abnormal_hematopoietic_stem0.73750769
129MP0004272_abnormal_basement_membrane0.73646728
130MP0002722_abnormal_immune_system0.73518048
131MP0003091_abnormal_cell_migration0.73081596
132MP0005501_abnormal_skin_physiology0.71278486
133MP0002136_abnormal_kidney_physiology0.70110262
134MP0001800_abnormal_humoral_immune0.70023062
135MP0003186_abnormal_redox_activity0.69850293
136MP0000767_abnormal_smooth_muscle0.69689639
137MP0005397_hematopoietic_system_phenotyp0.69460426
138MP0001545_abnormal_hematopoietic_system0.69460426
139MP0005451_abnormal_body_composition0.69196300
140MP0003448_altered_tumor_morphology0.69129445
141MP0002019_abnormal_tumor_incidence0.68255934
142MP0001958_emphysema0.67525789
143MP0002092_abnormal_eye_morphology0.67254563
144MP0010155_abnormal_intestine_physiology0.66844401
145MP0002396_abnormal_hematopoietic_system0.65509323
146MP0002085_abnormal_embryonic_tissue0.65282765
147MP0001853_heart_inflammation0.64978637
148MP0000377_abnormal_hair_follicle0.64897039

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.86076104
2Vertebral compression fractures (HP:0002953)3.37257940
3Xanthomatosis (HP:0000991)3.32173676
4Protrusio acetabuli (HP:0003179)3.17423462
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.14651939
6Increased connective tissue (HP:0009025)2.93471033
7Multiple enchondromatosis (HP:0005701)2.85456583
8Premature rupture of membranes (HP:0001788)2.76897450
9Distal lower limb amyotrophy (HP:0008944)2.75852526
10Centrally nucleated skeletal muscle fibers (HP:0003687)2.70516070
11Cerebral aneurysm (HP:0004944)2.70412730
12Intrahepatic cholestasis (HP:0001406)2.64812241
13Spinal rigidity (HP:0003306)2.61807977
14Increased variability in muscle fiber diameter (HP:0003557)2.57386969
15Hypobetalipoproteinemia (HP:0003563)2.55976082
16Distal lower limb muscle weakness (HP:0009053)2.54485619
17Abnormality of skeletal muscle fiber size (HP:0012084)2.54363066
18Complement deficiency (HP:0004431)2.53032142
19Myocardial infarction (HP:0001658)2.52495413
20Spastic diplegia (HP:0001264)2.52394468
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49357092
22Peritonitis (HP:0002586)2.46923810
23Ulnar bowing (HP:0003031)2.36465607
24Hypoglycemic coma (HP:0001325)2.36265334
25Hyperammonemia (HP:0001987)2.36035840
26Abnormality of complement system (HP:0005339)2.34651413
27Disproportionate tall stature (HP:0001519)2.34401298
28Abnormal cartilage morphology (HP:0002763)2.34024234
29Esophageal varix (HP:0002040)2.31192498
30Fragile skin (HP:0001030)2.29620035
31Abnormality of the Achilles tendon (HP:0005109)2.27030489
32Rhabdomyolysis (HP:0003201)2.25195613
33Cervical subluxation (HP:0003308)2.24922173
34Hyperglycinuria (HP:0003108)2.23651267
35Hypolipoproteinemia (HP:0010981)2.23247020
36Myoglobinuria (HP:0002913)2.20916756
37Hypoalphalipoproteinemia (HP:0003233)2.17246152
38Difficulty climbing stairs (HP:0003551)2.13818935
39Cellulitis (HP:0100658)2.12490776
40Shallow orbits (HP:0000586)2.12291600
41Exercise-induced muscle cramps (HP:0003710)2.11044257
42Bladder diverticulum (HP:0000015)2.10695388
43Broad face (HP:0000283)2.10397025
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08999112
45Mitral valve prolapse (HP:0001634)2.08268518
46Back pain (HP:0003418)2.05974004
47Syringomyelia (HP:0003396)2.05842268
48Spinal cord lesions (HP:0100561)2.05842268
49Achilles tendon contracture (HP:0001771)2.05134187
50Eczematoid dermatitis (HP:0000976)2.05094602
51Lymphangioma (HP:0100764)2.04293843
52Wormian bones (HP:0002645)2.04222398
53Polycythemia (HP:0001901)2.03492469
54Ketosis (HP:0001946)2.03379799
55Increased density of long bones (HP:0006392)2.02841980
56Right ventricular cardiomyopathy (HP:0011663)2.02749587
57Flat acetabular roof (HP:0003180)2.01874742
58Mitral regurgitation (HP:0001653)2.01508794
59Vascular tortuosity (HP:0004948)2.01397682
60Abnormality of the common coagulation pathway (HP:0010990)2.01122769
61Mildly elevated creatine phosphokinase (HP:0008180)2.00859514
62Ankle contracture (HP:0006466)2.00579230
63Long palpebral fissure (HP:0000637)2.00527896
64Rectal prolapse (HP:0002035)2.00446277
65Abnormality of serine family amino acid metabolism (HP:0010894)1.99564002
66Abnormality of glycine metabolism (HP:0010895)1.99564002
67Systemic lupus erythematosus (HP:0002725)1.99063595
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98011838
69Atrophic scars (HP:0001075)1.98001637
70Hyperlipoproteinemia (HP:0010980)1.97994653
71Abnormality of the distal phalanges of the toes (HP:0010182)1.96304444
72Asymmetry of the thorax (HP:0001555)1.96086675
73Late onset (HP:0003584)1.95765815
74Abnormality of sulfur amino acid metabolism (HP:0004339)1.95416476
75Arterial tortuosity (HP:0005116)1.94351213
76Short nail (HP:0001799)1.94291984
77Muscle fiber splitting (HP:0003555)1.91384469
78Type 1 muscle fiber predominance (HP:0003803)1.90714862
79Osteolytic defects of the phalanges of the hand (HP:0009771)1.89833508
80Osteolytic defects of the hand bones (HP:0009699)1.89833508
81Biconcave vertebral bodies (HP:0004586)1.89029567
82Elbow flexion contracture (HP:0002987)1.88744600
83Aneurysm (HP:0002617)1.86917264
84Hepatocellular carcinoma (HP:0001402)1.86677438
85Asymmetric septal hypertrophy (HP:0001670)1.86288439
86Generalized amyotrophy (HP:0003700)1.86269436
87Spondylolisthesis (HP:0003302)1.86138584
88Hyperparathyroidism (HP:0000843)1.84176046
89Emphysema (HP:0002097)1.83717989
90Metaphyseal cupping (HP:0003021)1.82386985
91Distal upper limb amyotrophy (HP:0007149)1.82204282
92Upper limb amyotrophy (HP:0009129)1.82204282
93Gout (HP:0001997)1.81823512
94Insomnia (HP:0100785)1.81591393
95Lower limb amyotrophy (HP:0007210)1.81214396
96Interstitial pulmonary disease (HP:0006530)1.80282402
97Ventricular tachycardia (HP:0004756)1.80133024
98Myopathic facies (HP:0002058)1.79500336
99Abnormality of macrophages (HP:0004311)1.79370294
100Fatigue (HP:0012378)1.78770985
101Hyporeflexia of lower limbs (HP:0002600)1.78654946
102Ulnar deviation of the wrist (HP:0003049)1.77699010
103Slender build (HP:0001533)1.77361536
104Abnormality of pyrimidine metabolism (HP:0004353)1.76047192
105Abnormality of oral frenula (HP:0000190)1.74523420
106Persistence of primary teeth (HP:0006335)1.74272764
107Segmental peripheral demyelination/remyelination (HP:0003481)1.73357731
108Gastrointestinal stroma tumor (HP:0100723)1.73290751
109Dysostosis multiplex (HP:0000943)1.73183110
110Trismus (HP:0000211)1.73112791
111Abnormality of the thoracic spine (HP:0100711)1.72882443
112Blue sclerae (HP:0000592)1.72539767
113Natal tooth (HP:0000695)1.72035141
114Hyperglycinemia (HP:0002154)1.71765929
115Mesangial abnormality (HP:0001966)1.71154714
116Abnormality of glycolipid metabolism (HP:0010969)1.70217714
117Abnormality of liposaccharide metabolism (HP:0010968)1.70217714
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.70217714
119Abnormality of fatty-acid metabolism (HP:0004359)1.69835767
120Genu recurvatum (HP:0002816)1.69738504
121Abnormality of iron homeostasis (HP:0011031)1.69203720
122Pseudobulbar signs (HP:0002200)1.69107782
123Difficulty running (HP:0009046)1.68992481
124Increased serum ferritin (HP:0003281)1.67432605
125Obstructive sleep apnea (HP:0002870)1.67424146
126Hematochezia (HP:0002573)1.66748888
127Abnormality of nucleobase metabolism (HP:0010932)1.66310384
128Joint laxity (HP:0001388)1.66219960
129Papilloma (HP:0012740)1.66176145
130Verrucae (HP:0200043)1.66176145
131Epidermoid cyst (HP:0200040)1.65749191
132Ketoacidosis (HP:0001993)1.65681275
133Increased IgE level (HP:0003212)1.65052484
134Progressive muscle weakness (HP:0003323)1.64732021
135Hemorrhage of the eye (HP:0011885)1.64625526
136Ankyloglossia (HP:0010296)1.64612821
137Angiofibromas (HP:0010615)1.64575043
138Adenoma sebaceum (HP:0009720)1.64575043
139Hypertensive crisis (HP:0100735)1.64250030
140Dilatation of the ascending aorta (HP:0005111)1.63862358
141Abnormality of transition element cation homeostasis (HP:0011030)1.63471609
142Subacute progressive viral hepatitis (HP:0006572)1.63067604
143Axonal loss (HP:0003447)1.63025448
144Cupped ribs (HP:0000887)1.63010345
145Malnutrition (HP:0004395)1.62045000
146Round ear (HP:0100830)1.61582457
147Abnormality of purine metabolism (HP:0004352)1.61441979
148Abnormality of the acetabulum (HP:0003170)1.61262291
149Exercise-induced myalgia (HP:0003738)1.60468572
150Hyperacusis (HP:0010780)1.60400802
151Abnormality of the peritoneum (HP:0002585)1.59955850
152Skin nodule (HP:0200036)1.58896786
153Increased mean platelet volume (HP:0011877)1.58275788
154Thin bony cortex (HP:0002753)1.57869437
155Abnormality of the nasal mucosa (HP:0000433)1.57650558
156Aortic dissection (HP:0002647)1.55903957
157Chondrocalcinosis (HP:0000934)1.55671598
158Abnormal ossification of hand bones (HP:0005921)1.55614356
159Thoracic kyphosis (HP:0002942)1.55420347
160Joint hemorrhage (HP:0005261)1.55145304
161Polygenic inheritance (HP:0010982)1.54325169
162Hypercholesterolemia (HP:0003124)1.54255286
163Aortic aneurysm (HP:0004942)1.53893532
164Hyperextensible skin (HP:0000974)1.53755742
165Bowed forearm bones (HP:0003956)1.53669605
166Bowing of the arm (HP:0006488)1.53669605
167Patellar dislocation (HP:0002999)1.53047234
168Abnormality of the distal phalanx of the thumb (HP:0009617)1.51702123
169Abnormality of the calcaneus (HP:0008364)1.51466550
170Bone pain (HP:0002653)1.51366073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.54851740
2PKN23.83834901
3PRPF4B3.74688569
4MAP3K103.25177908
5ERN12.99133861
6SMG12.98386411
7EEF2K2.91450078
8IRAK32.78137327
9TTN2.51133808
10SIK12.05757698
11LRRK21.94418134
12BCKDK1.93002977
13MAP4K11.91712613
14FGFR41.91042756
15PTK61.82926063
16TAOK21.81545056
17CDK121.75066624
18STK101.69537460
19EPHA21.48467193
20PAK41.46307391
21MAP3K131.43782631
22RPS6KA41.38380441
23MAP3K141.35357097
24NEK21.34570935
25TESK21.31372259
26BMX1.31205008
27LATS11.30220527
28RPS6KB21.29444194
29NME21.27207555
30KDR1.26941255
31MAP2K31.26097273
32FLT31.24066647
33ARAF1.23433194
34TYK21.23267925
35KSR21.22795903
36EPHB11.22599241
37RIPK11.22413427
38PDGFRA1.21504802
39GRK61.20043388
40NEK11.19579994
41MST1R1.17708967
42MAP3K81.14453202
43CDK41.12323995
44TGFBR21.11913113
45CDC42BPA1.09411864
46MOS1.07428507
47MAP3K111.06788398
48MTOR1.06136547
49MAP3K31.05147415
50CDK61.03454845
51RIPK41.00278504
52ICK0.99197134
53TBK10.96000515
54MAP3K10.93529883
55IRAK40.92315967
56PRKD20.91874643
57NEK90.91238035
58MET0.90959259
59ZAP700.90060336
60SIK30.86972797
61ALK0.84815068
62BUB10.84611515
63DYRK1B0.84581223
64ILK0.83872684
65STK40.83608450
66PIM10.83428135
67TGFBR10.80159975
68PAK20.79473374
69SCYL20.79231658
70BLK0.78562504
71STK30.78475072
72PASK0.74343993
73CSK0.72182587
74CSF1R0.71732723
75MAPKAPK30.69814387
76JAK30.67959267
77PDPK10.66612401
78RPS6KA20.66479558
79WEE10.65869358
80LIMK10.64998550
81FGFR30.64805311
82TTK0.63327518
83CHUK0.63180541
84MAPK110.63115865
85TESK10.62698919
86DDR20.60897476
87CDK70.60535783
88HIPK20.60304607
89TLK10.59665362
90PTK20.59573284
91BRAF0.59277669
92MARK20.58983230
93IRAK20.58801161
94MAP2K20.58667079
95MARK30.58008965
96EPHA30.57957008
97MAP3K60.57795657
98DYRK30.56540807
99PIM20.56100076
100CLK10.55959141
101LMTK20.55255683
102AURKB0.54126173
103EPHB20.53982888
104JAK10.52672761
105BTK0.51111517
106NTRK10.49739342
107MYLK0.48810766
108MAP3K70.48567417
109JAK20.48244904
110FGFR10.48071654
111RPS6KA10.46846778
112ITK0.46754843
113GSK3A0.46281032
114AKT20.45511854
115RET0.43297327
116PAK10.42958812
117DMPK0.42242454
118PRKG20.42133738
119CDK90.41944432
120IKBKB0.41085077
121CAMK1D0.38327227
122RAF10.36554117
123LATS20.35410484
124PRKD30.35213426
125TAOK10.35001492
126CDK80.34689694
127MAPKAPK20.34456938
128PDGFRB0.34414183
129MAPK70.34371638
130HCK0.34183104
131CDC70.33387739
132PIK3CG0.33118686
133RPS6KC10.33008516
134RPS6KL10.33008516
135RPS6KA60.32374169

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90225211
2Nitrogen metabolism_Homo sapiens_hsa009102.46045022
3Other glycan degradation_Homo sapiens_hsa005112.25828095
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25696744
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.23384756
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19515993
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09999997
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09618676
9Arginine biosynthesis_Homo sapiens_hsa002202.01682614
10Fatty acid degradation_Homo sapiens_hsa000711.97845423
11One carbon pool by folate_Homo sapiens_hsa006701.81688278
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77945314
13Pancreatic cancer_Homo sapiens_hsa052121.76834815
14Selenocompound metabolism_Homo sapiens_hsa004501.76720495
15Tryptophan metabolism_Homo sapiens_hsa003801.76204104
16Complement and coagulation cascades_Homo sapiens_hsa046101.66366398
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64719269
18Non-small cell lung cancer_Homo sapiens_hsa052231.62580441
19Biosynthesis of amino acids_Homo sapiens_hsa012301.56149028
20Carbon metabolism_Homo sapiens_hsa012001.55924430
21Staphylococcus aureus infection_Homo sapiens_hsa051501.49567932
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49470151
23VEGF signaling pathway_Homo sapiens_hsa043701.47996546
24Prion diseases_Homo sapiens_hsa050201.47362710
25Osteoclast differentiation_Homo sapiens_hsa043801.47353509
26Shigellosis_Homo sapiens_hsa051311.46434258
27Sulfur relay system_Homo sapiens_hsa041221.46042869
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45524067
29Thyroid cancer_Homo sapiens_hsa052161.45382942
30PPAR signaling pathway_Homo sapiens_hsa033201.41194002
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39507868
32Hepatitis B_Homo sapiens_hsa051611.36289782
33Renal cell carcinoma_Homo sapiens_hsa052111.33367516
34Caffeine metabolism_Homo sapiens_hsa002321.30830821
35Lysine degradation_Homo sapiens_hsa003101.30225973
36Fatty acid metabolism_Homo sapiens_hsa012121.29308909
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.27608824
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27560784
39Endometrial cancer_Homo sapiens_hsa052131.24713368
40Ribosome_Homo sapiens_hsa030101.24531616
41Influenza A_Homo sapiens_hsa051641.22846001
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.22197311
43Pentose phosphate pathway_Homo sapiens_hsa000301.20938043
44Propanoate metabolism_Homo sapiens_hsa006401.20653960
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.20111846
46TNF signaling pathway_Homo sapiens_hsa046681.18352627
47Measles_Homo sapiens_hsa051621.16134917
48Hepatitis C_Homo sapiens_hsa051601.12860017
49Fat digestion and absorption_Homo sapiens_hsa049751.09142868
50Salmonella infection_Homo sapiens_hsa051321.04744984
51Prostate cancer_Homo sapiens_hsa052151.04573063
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04140479
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02708921
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02376431
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.99953441
56Small cell lung cancer_Homo sapiens_hsa052220.99929155
57Folate biosynthesis_Homo sapiens_hsa007900.99282914
58T cell receptor signaling pathway_Homo sapiens_hsa046600.99134465
59Malaria_Homo sapiens_hsa051440.96793598
60Chronic myeloid leukemia_Homo sapiens_hsa052200.95731430
61Insulin signaling pathway_Homo sapiens_hsa049100.95721043
62Glioma_Homo sapiens_hsa052140.95660555
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94906438
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93654774
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93244466
66Phenylalanine metabolism_Homo sapiens_hsa003600.93142633
67Lysosome_Homo sapiens_hsa041420.92601872
68beta-Alanine metabolism_Homo sapiens_hsa004100.92333122
69Starch and sucrose metabolism_Homo sapiens_hsa005000.91178086
70Peroxisome_Homo sapiens_hsa041460.90702112
71Prolactin signaling pathway_Homo sapiens_hsa049170.89196598
72Colorectal cancer_Homo sapiens_hsa052100.87910588
73Insulin resistance_Homo sapiens_hsa049310.87032056
74Pyruvate metabolism_Homo sapiens_hsa006200.86255609
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85789565
76Tuberculosis_Homo sapiens_hsa051520.85244843
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84791769
78ErbB signaling pathway_Homo sapiens_hsa040120.83813711
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83475618
80Endocytosis_Homo sapiens_hsa041440.83434103
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83367457
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82255039
83Epstein-Barr virus infection_Homo sapiens_hsa051690.82010039
84Butanoate metabolism_Homo sapiens_hsa006500.80348684
85Chemical carcinogenesis_Homo sapiens_hsa052040.80340785
86Arginine and proline metabolism_Homo sapiens_hsa003300.79261120
87DNA replication_Homo sapiens_hsa030300.78924881
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77970066
89Pertussis_Homo sapiens_hsa051330.77698789
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.77570307
91Antigen processing and presentation_Homo sapiens_hsa046120.77125741
92RNA transport_Homo sapiens_hsa030130.76232685
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.75873128
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75261464
95Viral myocarditis_Homo sapiens_hsa054160.75176873
96Bladder cancer_Homo sapiens_hsa052190.74775503
97Galactose metabolism_Homo sapiens_hsa000520.73807558
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73000688
99Notch signaling pathway_Homo sapiens_hsa043300.72038919
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71302085
101Systemic lupus erythematosus_Homo sapiens_hsa053220.71169462
102Tyrosine metabolism_Homo sapiens_hsa003500.71016213
103Bile secretion_Homo sapiens_hsa049760.70482867
104Acute myeloid leukemia_Homo sapiens_hsa052210.70480458
105Histidine metabolism_Homo sapiens_hsa003400.70196480
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67964786
107Viral carcinogenesis_Homo sapiens_hsa052030.67817903
108Chemokine signaling pathway_Homo sapiens_hsa040620.67565409
109Legionellosis_Homo sapiens_hsa051340.67362575
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67356549
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.67142639
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66639758
113Spliceosome_Homo sapiens_hsa030400.66597797
114Proteoglycans in cancer_Homo sapiens_hsa052050.66125008
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.65029818
116GnRH signaling pathway_Homo sapiens_hsa049120.63981860
117Fructose and mannose metabolism_Homo sapiens_hsa000510.63673568
118Adherens junction_Homo sapiens_hsa045200.62927010
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61583355
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61478147
121MicroRNAs in cancer_Homo sapiens_hsa052060.61425644
122mTOR signaling pathway_Homo sapiens_hsa041500.60869733
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60559372
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.60414658
125Platelet activation_Homo sapiens_hsa046110.59764528
126Apoptosis_Homo sapiens_hsa042100.59429429
127p53 signaling pathway_Homo sapiens_hsa041150.59233062
128Glutathione metabolism_Homo sapiens_hsa004800.59228315
129Retinol metabolism_Homo sapiens_hsa008300.58506656
130Focal adhesion_Homo sapiens_hsa045100.58167138
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.57323119
132Pathways in cancer_Homo sapiens_hsa052000.56586490
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56503033
134AMPK signaling pathway_Homo sapiens_hsa041520.56037466
135Vibrio cholerae infection_Homo sapiens_hsa051100.55974553
136B cell receptor signaling pathway_Homo sapiens_hsa046620.55723527
137Toxoplasmosis_Homo sapiens_hsa051450.55456502
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54289605
139Estrogen signaling pathway_Homo sapiens_hsa049150.54127911
140Leishmaniasis_Homo sapiens_hsa051400.53865251
141Phagosome_Homo sapiens_hsa041450.52077063
142Base excision repair_Homo sapiens_hsa034100.52041604
143Choline metabolism in cancer_Homo sapiens_hsa052310.51850060
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.50903434
145HTLV-I infection_Homo sapiens_hsa051660.50085434
146ECM-receptor interaction_Homo sapiens_hsa045120.50044668
147Amoebiasis_Homo sapiens_hsa051460.48035587
148Allograft rejection_Homo sapiens_hsa053300.46735982
149Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46430003
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.46064989
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45093880
152Mismatch repair_Homo sapiens_hsa034300.43475168
153Herpes simplex infection_Homo sapiens_hsa051680.42807016
154HIF-1 signaling pathway_Homo sapiens_hsa040660.40820824
155Primary immunodeficiency_Homo sapiens_hsa053400.40579182
156Cell cycle_Homo sapiens_hsa041100.39578941
157Steroid hormone biosynthesis_Homo sapiens_hsa001400.39497097
158ABC transporters_Homo sapiens_hsa020100.38168243

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