SZT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of establishment of cell polarity (GO:2000114)5.08062291
2regulation of MHC class I biosynthetic process (GO:0045343)4.91574775
3indole-containing compound catabolic process (GO:0042436)4.53880369
4indolalkylamine catabolic process (GO:0046218)4.53880369
5tryptophan catabolic process (GO:0006569)4.53880369
6monoubiquitinated protein deubiquitination (GO:0035520)4.49143776
7regulation of establishment or maintenance of cell polarity (GO:0032878)4.35157014
8regulation of memory T cell differentiation (GO:0043380)4.25945617
9sodium ion export (GO:0071436)4.24868336
10phospholipid translocation (GO:0045332)4.23944756
11lipid translocation (GO:0034204)4.23944756
12histone H3-K4 trimethylation (GO:0080182)4.21863512
13negative regulation of cell killing (GO:0031342)4.19972629
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19972629
15kynurenine metabolic process (GO:0070189)4.11796832
16indolalkylamine metabolic process (GO:0006586)3.91281442
17tryptophan metabolic process (GO:0006568)3.85472849
18pre-miRNA processing (GO:0031054)3.85384435
19histone H3-K4 methylation (GO:0051568)3.82681793
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.80143234
21cellular response to ethanol (GO:0071361)3.76734444
22regulation of NFAT protein import into nucleus (GO:0051532)3.70830260
23positive regulation of histone deacetylation (GO:0031065)3.67491014
24establishment of nucleus localization (GO:0040023)3.65787081
25positive thymic T cell selection (GO:0045059)3.60277255
26negative regulation of multicellular organism growth (GO:0040015)3.60129252
27protein K48-linked deubiquitination (GO:0071108)3.56016116
28positive regulation of developmental pigmentation (GO:0048087)3.55323449
29regulation of B cell receptor signaling pathway (GO:0050855)3.54988957
30snRNA transcription (GO:0009301)3.49688794
31cytoplasmic mRNA processing body assembly (GO:0033962)3.49227312
32interkinetic nuclear migration (GO:0022027)3.48168086
33regulation of gamma-delta T cell differentiation (GO:0045586)3.46498798
34establishment of protein localization to Golgi (GO:0072600)3.43361524
35positive regulation of gamma-delta T cell activation (GO:0046645)3.39528185
36regulation of ARF protein signal transduction (GO:0032012)3.38401603
37negative regulation of type 2 immune response (GO:0002829)3.26440082
38NAD biosynthetic process (GO:0009435)3.25508083
39locomotory exploration behavior (GO:0035641)3.23650384
40sex differentiation (GO:0007548)3.23368683
41regulation of hippo signaling (GO:0035330)3.21082471
42stress granule assembly (GO:0034063)3.20201028
43regulation of pigment cell differentiation (GO:0050932)3.20187536
44negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17031946
45cilium or flagellum-dependent cell motility (GO:0001539)3.16417066
46positive T cell selection (GO:0043368)3.15880044
47regulation of ARF GTPase activity (GO:0032312)3.14060947
48peptidyl-lysine dimethylation (GO:0018027)3.13623484
49regulation of gamma-delta T cell activation (GO:0046643)3.10110673
50cerebellar Purkinje cell differentiation (GO:0021702)3.09970349
51phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.09269136
52histone lysine methylation (GO:0034968)3.08160733
53positive regulation of vasculogenesis (GO:2001214)3.06288714
54histone H3-K36 demethylation (GO:0070544)3.03237434
55negative regulation of histone methylation (GO:0031061)3.02934653
56thymic T cell selection (GO:0045061)3.02618461
57layer formation in cerebral cortex (GO:0021819)3.01646999
58peptidyl-lysine trimethylation (GO:0018023)3.00076906
59protein K63-linked deubiquitination (GO:0070536)2.96164015
60positive regulation of gene expression, epigenetic (GO:0045815)2.94537773
61protein K11-linked deubiquitination (GO:0035871)2.86655218
62negative regulation of cell size (GO:0045792)2.83635618
63insulin-like growth factor receptor signaling pathway (GO:0048009)2.81523477
64T cell selection (GO:0045058)2.81018528
65positive regulation of RNA splicing (GO:0033120)2.78722899
66striated muscle atrophy (GO:0014891)2.76544576
67negative regulation of calcium ion transport into cytosol (GO:0010523)2.75774275
68signal peptide processing (GO:0006465)2.75314425
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.74835228
70positive regulation of Rap GTPase activity (GO:0032854)2.74449891
71regulation of sarcomere organization (GO:0060297)2.72889785
72sterol catabolic process (GO:0016127)2.72091085
73cholesterol catabolic process (GO:0006707)2.72091085
74histone H3-K9 demethylation (GO:0033169)2.70446180
75activation of JUN kinase activity (GO:0007257)2.68079072
76regulation of gene silencing by RNA (GO:0060966)2.67666732
77regulation of posttranscriptional gene silencing (GO:0060147)2.67666732
78regulation of gene silencing by miRNA (GO:0060964)2.67666732
79indole-containing compound metabolic process (GO:0042430)2.67017035
80positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.66560000
81mannose metabolic process (GO:0006013)2.66423501
82histone H4-K16 acetylation (GO:0043984)2.65250512
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64533495
84negative thymic T cell selection (GO:0045060)2.64055395
85synaptic vesicle maturation (GO:0016188)2.63317067
86cellular potassium ion homeostasis (GO:0030007)2.62401370
87negative T cell selection (GO:0043383)2.61332715
88negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61244297
89negative regulation of translation, ncRNA-mediated (GO:0040033)2.61244297
90regulation of translation, ncRNA-mediated (GO:0045974)2.61244297
91peptidyl-lysine methylation (GO:0018022)2.60881418
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60246378
93adherens junction assembly (GO:0034333)2.58241692
94regulation of membrane lipid distribution (GO:0097035)2.58016000
95chromatin silencing (GO:0006342)2.57771360
96negative regulation of nucleotide catabolic process (GO:0030812)2.57155473
97cell communication by electrical coupling (GO:0010644)2.57098746
98positive regulation of CREB transcription factor activity (GO:0032793)2.57061356
99histone methylation (GO:0016571)2.55618752
100positive regulation of fatty acid beta-oxidation (GO:0032000)2.54067368
101intracellular estrogen receptor signaling pathway (GO:0030520)2.54026592
102detection of light stimulus involved in visual perception (GO:0050908)2.53095377
103detection of light stimulus involved in sensory perception (GO:0050962)2.53095377
104neural tube formation (GO:0001841)2.52477478
105positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52363751
106amine catabolic process (GO:0009310)2.52060298
107cellular biogenic amine catabolic process (GO:0042402)2.52060298
108skeletal muscle adaptation (GO:0043501)2.51909841
109nucleosome disassembly (GO:0006337)2.50200199
110protein-DNA complex disassembly (GO:0032986)2.50200199
111regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49490045
112nucleoside diphosphate catabolic process (GO:0009134)2.49093345
113positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.49069125
114pyridine nucleotide biosynthetic process (GO:0019363)2.49029697
115nicotinamide nucleotide biosynthetic process (GO:0019359)2.49029697
116regulation of Rap GTPase activity (GO:0032317)2.48783141
117dicarboxylic acid biosynthetic process (GO:0043650)2.48159539
118cortical actin cytoskeleton organization (GO:0030866)2.47979699
119positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46806831
120positive regulation of fatty acid oxidation (GO:0046321)2.46192939
121cellular response to exogenous dsRNA (GO:0071360)2.46179963
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45154637
123peptidyl-threonine phosphorylation (GO:0018107)2.45120605
124histone H4 acetylation (GO:0043967)2.43058114
125nucleus localization (GO:0051647)2.41149951
126regulation of interleukin-5 production (GO:0032674)2.40116609
127focal adhesion assembly (GO:0048041)2.39677986
128cell-substrate adherens junction assembly (GO:0007045)2.39677986
129regulation of clathrin-mediated endocytosis (GO:2000369)2.38614966
130regulation of vasculogenesis (GO:2001212)2.37345277
131centrosome duplication (GO:0051298)2.37206899
132histone H3-K9 modification (GO:0061647)2.36713389
133positive regulation of protein deacetylation (GO:0090312)2.36009566
134pericardium development (GO:0060039)2.35560947
135regulation of histone deacetylation (GO:0031063)2.34710610
136retrograde transport, vesicle recycling within Golgi (GO:0000301)2.34110864
137potassium ion import (GO:0010107)2.34069130
138regulation of Rab GTPase activity (GO:0032313)2.34022989
139positive regulation of Rab GTPase activity (GO:0032851)2.34022989
140protein targeting to Golgi (GO:0000042)2.32889840
141regulation of chromatin binding (GO:0035561)2.32796094
142histone H3-K9 methylation (GO:0051567)2.32674914
143auditory receptor cell stereocilium organization (GO:0060088)2.32395548
144glucocorticoid receptor signaling pathway (GO:0042921)2.31791853
145dendritic spine morphogenesis (GO:0060997)2.31646239
146phosphatidylethanolamine biosynthetic process (GO:0006646)2.31105381
147negative regulation of gene expression, epigenetic (GO:0045814)2.29643250
148regulation of protein deacetylation (GO:0090311)2.28313722
149peptidyl-threonine modification (GO:0018210)2.28151429
150negative regulation of purine nucleotide catabolic process (GO:0033122)2.27389592
151UDP-N-acetylglucosamine metabolic process (GO:0006047)2.27286484
152neural tube development (GO:0021915)2.26685102
153interleukin-6-mediated signaling pathway (GO:0070102)2.25930954
154glial cell proliferation (GO:0014009)2.25783453
155regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.24369346
156positive regulation of granulocyte differentiation (GO:0030854)2.24037827
157flavonoid metabolic process (GO:0009812)2.23945319
158positive regulation of synapse maturation (GO:0090129)2.23456249
159NLS-bearing protein import into nucleus (GO:0006607)2.22756312
160receptor catabolic process (GO:0032801)2.22506743
161clathrin coat assembly (GO:0048268)2.22325161
162aromatic amino acid family catabolic process (GO:0009074)2.21831468
163regulation of triglyceride catabolic process (GO:0010896)2.20962734
164regulation of fatty acid beta-oxidation (GO:0031998)2.20804561
165killing of cells of other organism (GO:0031640)2.19919254
166disruption of cells of other organism (GO:0044364)2.19919254
167epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19630408
168regulation of translational fidelity (GO:0006450)2.19409134
169regulation of p38MAPK cascade (GO:1900744)2.17930126
170negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.17884212
171regulation of interleukin-12 biosynthetic process (GO:0045075)2.17737958
172histone H4-K5 acetylation (GO:0043981)2.17456707
173histone H4-K8 acetylation (GO:0043982)2.17456707
174G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.16155512
175synaptic vesicle endocytosis (GO:0048488)2.14695191
176erythrocyte maturation (GO:0043249)2.14407354
177negative regulation of GTP catabolic process (GO:0033125)2.14346321
178negative regulation of GTPase activity (GO:0034260)2.14346321
179heart morphogenesis (GO:0003007)2.14277765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.65904800
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.33636471
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09460178
4KDM2B_26808549_Chip-Seq_SUP-B15_Human3.06524192
5KDM2B_26808549_Chip-Seq_DND41_Human3.01855484
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98009323
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90057323
8TCF7_22412390_ChIP-Seq_EML_Mouse2.74413272
9VDR_21846776_ChIP-Seq_THP-1_Human2.68762953
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65600195
11GBX2_23144817_ChIP-Seq_PC3_Human2.61186142
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.56501563
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.49264394
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.46392710
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.35792289
16KDM2B_26808549_Chip-Seq_K562_Human2.31335960
17DROSHA_22980978_ChIP-Seq_HELA_Human2.26914621
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24124107
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.19672441
20ZFP281_27345836_Chip-Seq_ESCs_Mouse2.15198168
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.13164897
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.06888112
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05935594
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05320873
25VDR_22108803_ChIP-Seq_LS180_Human2.04804846
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02987735
27LXR_22292898_ChIP-Seq_THP-1_Human1.99568666
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.99500325
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98769081
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97555416
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96154522
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95883375
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.95062626
34UTX_26944678_Chip-Seq_JUKART_Human1.85701412
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85040726
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.83132038
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.81458663
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.73935212
39MAF_26560356_Chip-Seq_TH1_Human1.72885327
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71361401
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71049230
42AR_21572438_ChIP-Seq_LNCaP_Human1.69015696
43RUNX_20019798_ChIP-Seq_JUKART_Human1.69014016
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67791553
45STAT3_23295773_ChIP-Seq_U87_Human1.67690858
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66459161
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64925816
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62201852
49ER_23166858_ChIP-Seq_MCF-7_Human1.61095588
50SPI1_23127762_ChIP-Seq_K562_Human1.61022771
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.60616127
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60418774
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58978926
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55783178
55TP53_16413492_ChIP-PET_HCT116_Human1.55382167
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.54144824
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54093256
58BCAT_22108803_ChIP-Seq_LS180_Human1.53143587
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52531944
60VDR_24763502_ChIP-Seq_THP-1_Human1.50919219
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49346149
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49344172
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48840250
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48689215
65E2F7_22180533_ChIP-Seq_HELA_Human1.46983819
66TAF15_26573619_Chip-Seq_HEK293_Human1.46839316
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46390663
68TCF4_23295773_ChIP-Seq_U87_Human1.45317860
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41953889
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.40920203
71TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.40219946
72SCL_19346495_ChIP-Seq_HPC-7_Human1.39235104
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.37564702
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.36886554
75CIITA_25753668_ChIP-Seq_RAJI_Human1.36526291
76RACK7_27058665_Chip-Seq_MCF-7_Human1.36516811
77VDR_24787735_ChIP-Seq_THP-1_Human1.35373791
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35062867
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33811856
80P68_20966046_ChIP-Seq_HELA_Human1.32828818
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32737010
82IGF1R_20145208_ChIP-Seq_DFB_Human1.32730477
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32563469
84CREB1_26743006_Chip-Seq_LNCaP_Human1.32049033
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30769984
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.30049386
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29635247
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29577398
89SMAD4_21799915_ChIP-Seq_A2780_Human1.29120209
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28664896
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28612985
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26999071
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26477022
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.24249176
95GATA1_19941826_ChIP-Seq_K562_Human1.23990103
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.23826610
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23716579
98SMC4_20622854_ChIP-Seq_HELA_Human1.23341361
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23119969
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22369998
101RXR_22108803_ChIP-Seq_LS180_Human1.22203653
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21765273
103EZH2_22144423_ChIP-Seq_EOC_Human1.20456199
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19411798
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19411798
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16949439
107ZNF274_21170338_ChIP-Seq_K562_Hela1.14790132
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13917365
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.13708895
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13668858
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.12589406
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.12433655
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12057131
114MAF_26560356_Chip-Seq_TH2_Human1.11491140
115MYB_26560356_Chip-Seq_TH1_Human1.10492686
116KDM2B_26808549_Chip-Seq_REH_Human1.09666724
117NCOR1_26117541_ChIP-Seq_K562_Human1.09074734
118CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08744501
119OCT1_27270436_Chip-Seq_PROSTATE_Human1.08654729
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07433061
121ISL1_27105846_Chip-Seq_CPCs_Mouse1.07150012
122AR_25329375_ChIP-Seq_VCAP_Human1.06884846
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.06533127
124PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06055459
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05435618
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03595117
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03509806
128* TBX20_22328084_ChIP-Seq_HEART_Mouse1.03213124
129* TBX20_22080862_ChIP-Seq_HEART_Mouse1.03213124
130VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03066768
131CJUN_26792858_Chip-Seq_BT549_Human1.01944656
132FOXA2_19822575_ChIP-Seq_HepG2_Human1.01564896
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00510624
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00498896
135CBP_20019798_ChIP-Seq_JUKART_Human1.00498896
136MYB_26560356_Chip-Seq_TH2_Human1.00363521
137SMRT_27268052_Chip-Seq_Bcells_Human1.00109522
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99066366
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98912238
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98170920
141CDX2_22108803_ChIP-Seq_LS180_Human0.97782220
142STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97637083
143TP63_23658742_ChIP-Seq_EP156T_Human0.97084843
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.96855769
145IRF8_27001747_Chip-Seq_BMDM_Mouse0.96396422
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96243659
147JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96059243
148FLI1_21867929_ChIP-Seq_TH2_Mouse0.95291660
149RUNX2_22187159_ChIP-Seq_PCA_Human0.95230636
150WDR5_24793694_ChIP-Seq_LNCAP_Human0.95180462
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94908991
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94628260
153TCF4_22108803_ChIP-Seq_LS180_Human0.94581962
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94522141
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.94277553
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93967432
157AHR_22903824_ChIP-Seq_MCF-7_Human0.93706428
158TP53_23651856_ChIP-Seq_MEFs_Mouse0.92484094
159TP53_22127205_ChIP-Seq_IMR90_Human0.92437805
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.92237619
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.92037320
162PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92003499
163OCT4_19829295_ChIP-Seq_ESCs_Human0.91679882
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.91669909
165TP63_22573176_ChIP-Seq_HFKS_Human0.91305046
166RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90836300
167BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90127519
168SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90048505
169P300_19829295_ChIP-Seq_ESCs_Human0.89979769
170SA1_27219007_Chip-Seq_ERYTHROID_Human0.89827802
171PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88686218
172TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88127900
173GATA3_27048872_Chip-Seq_THYMUS_Human0.87646258
174AR_19668381_ChIP-Seq_PC3_Human0.87129394
175GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87119379
176CTCF_27219007_Chip-Seq_Bcells_Human0.86122563
177CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85325853
178CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84633072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.25886200
2MP0008961_abnormal_basal_metabolism3.68575029
3MP0004859_abnormal_synaptic_plasticity3.26834282
4MP0008057_abnormal_DNA_replication3.15026229
5MP0009278_abnormal_bone_marrow3.11920586
6MP0001501_abnormal_sleep_pattern3.01784159
7MP0005076_abnormal_cell_differentiation2.96311014
8MP0003252_abnormal_bile_duct2.85974591
9MP0003300_gastrointestinal_ulcer2.77497811
10MP0003646_muscle_fatigue2.70115087
11MP0005310_abnormal_salivary_gland2.56009062
12MP0004381_abnormal_hair_follicle2.46767247
13MP0003303_peritoneal_inflammation2.36307051
14MP0003195_calcinosis2.20148127
15MP0002138_abnormal_hepatobiliary_system2.18326477
16MP0004043_abnormal_pH_regulation2.16674540
17MP0003045_fibrosis2.12271781
18MP0003787_abnormal_imprinting1.99489837
19MP0001986_abnormal_taste_sensitivity1.97606284
20MP0003950_abnormal_plasma_membrane1.95347770
21MP0003172_abnormal_lysosome_physiology1.93875959
22MP0000015_abnormal_ear_pigmentation1.91116297
23MP0003705_abnormal_hypodermis_morpholog1.90926472
24MP0002396_abnormal_hematopoietic_system1.86974326
25MP0002168_other_aberrant_phenotype1.75173567
26MP0002653_abnormal_ependyma_morphology1.70887490
27MP0005171_absent_coat_pigmentation1.64745288
28MP0000427_abnormal_hair_cycle1.63822196
29MP0001835_abnormal_antigen_presentation1.63814294
30MP0004185_abnormal_adipocyte_glucose1.58044652
31MP0004808_abnormal_hematopoietic_stem1.55445034
32MP0008995_early_reproductive_senescence1.52466199
33MP0009046_muscle_twitch1.52125720
34MP0002089_abnormal_postnatal_growth/wei1.47819275
35MP0000383_abnormal_hair_follicle1.46710234
36MP0001968_abnormal_touch/_nociception1.46409161
37MP0003635_abnormal_synaptic_transmissio1.45860323
38MP0010234_abnormal_vibrissa_follicle1.45465926
39MP0005551_abnormal_eye_electrophysiolog1.44220145
40MP0000703_abnormal_thymus_morphology1.43996841
41MP0010352_gastrointestinal_tract_polyps1.42866842
42MP0004510_myositis1.36652476
43MP0000733_abnormal_muscle_development1.35841671
44MP0005647_abnormal_sex_gland1.34615147
45MP0008569_lethality_at_weaning1.34107331
46MP0002166_altered_tumor_susceptibility1.32800075
47MP0003763_abnormal_thymus_physiology1.32037684
48MP0009115_abnormal_fat_cell1.31863244
49MP0001545_abnormal_hematopoietic_system1.30756034
50MP0005397_hematopoietic_system_phenotyp1.30756034
51MP0001348_abnormal_lacrimal_gland1.29871322
52MP0002909_abnormal_adrenal_gland1.27159190
53MP0001958_emphysema1.23901253
54MP0004858_abnormal_nervous_system1.23030393
55MP0003866_abnormal_defecation1.22482172
56MP0000003_abnormal_adipose_tissue1.20851682
57MP0003115_abnormal_respiratory_system1.19498085
58MP0001849_ear_inflammation1.18592426
59MP0005174_abnormal_tail_pigmentation1.18469139
60MP0009780_abnormal_chondrocyte_physiolo1.17769594
61MP0003879_abnormal_hair_cell1.17259859
62MP0002398_abnormal_bone_marrow1.15013708
63MP0003091_abnormal_cell_migration1.13711533
64MP0003283_abnormal_digestive_organ1.12621712
65MP0003724_increased_susceptibility_to1.11734897
66MP0006054_spinal_hemorrhage1.10993610
67MP0002723_abnormal_immune_serum1.10587011
68MP0003183_abnormal_peptide_metabolism1.09344287
69MP0001800_abnormal_humoral_immune1.09258427
70MP0005075_abnormal_melanosome_morpholog1.09223038
71MP0002933_joint_inflammation1.08804468
72MP0010630_abnormal_cardiac_muscle1.08094338
73MP0005375_adipose_tissue_phenotype1.07512962
74MP0004947_skin_inflammation1.06271247
75MP0002928_abnormal_bile_duct1.05769621
76MP0002452_abnormal_antigen_presenting1.04962076
77MP0000685_abnormal_immune_system1.04793201
78MP0002009_preneoplasia1.04780691
79MP0006082_CNS_inflammation1.04649979
80MP0004145_abnormal_muscle_electrophysio1.04610354
81MP0004885_abnormal_endolymph1.04489639
82MP0002925_abnormal_cardiovascular_devel1.04077726
83MP0005167_abnormal_blood-brain_barrier1.03866682
84MP0000470_abnormal_stomach_morphology1.03278084
85MP0004197_abnormal_fetal_growth/weight/1.03021338
86MP0004811_abnormal_neuron_physiology1.02306337
87* MP0000371_diluted_coat_color1.02160999
88MP0002063_abnormal_learning/memory/cond1.01234091
89MP0010386_abnormal_urinary_bladder1.01053814
90MP0010307_abnormal_tumor_latency1.00865673
91MP0000428_abnormal_craniofacial_morphol0.99789069
92MP0003566_abnormal_cell_adhesion0.98849207
93MP0005334_abnormal_fat_pad0.98188014
94MP0002419_abnormal_innate_immunity0.96058442
95MP0005377_hearing/vestibular/ear_phenot0.95438422
96MP0003878_abnormal_ear_physiology0.95438422
97MP0002420_abnormal_adaptive_immunity0.95119422
98MP0000751_myopathy0.94954007
99MP0001819_abnormal_immune_cell0.93448012
100MP0004130_abnormal_muscle_cell0.92898199
101MP0003690_abnormal_glial_cell0.92853531
102MP0001790_abnormal_immune_system0.92686809
103MP0005387_immune_system_phenotype0.92686809
104MP0002084_abnormal_developmental_patter0.91514666
105MP0008874_decreased_physiological_sensi0.91224064
106MP0002736_abnormal_nociception_after0.91223234
107MP0005671_abnormal_response_to0.89165369
108MP0004036_abnormal_muscle_relaxation0.88698086
109MP0005025_abnormal_response_to0.87631710
110MP0001730_embryonic_growth_arrest0.86824339
111* MP0008770_decreased_survivor_rate0.86262786
112MP0000230_abnormal_systemic_arterial0.85976172
113MP0003984_embryonic_growth_retardation0.85831335
114MP0002822_catalepsy0.85513375
115MP0003121_genomic_imprinting0.85433100
116MP0005666_abnormal_adipose_tissue0.85167025
117MP0002722_abnormal_immune_system0.84816109
118MP0004233_abnormal_muscle_weight0.84068054
119MP0004087_abnormal_muscle_fiber0.83920213
120MP0002693_abnormal_pancreas_physiology0.83185295
121MP0002088_abnormal_embryonic_growth/wei0.83028570
122MP0000778_abnormal_nervous_system0.82499492
123MP0002405_respiratory_system_inflammati0.82161281
124MP0002971_abnormal_brown_adipose0.81575630
125MP0003861_abnormal_nervous_system0.81572247
126MP0005253_abnormal_eye_physiology0.80629097
127MP0003935_abnormal_craniofacial_develop0.80505222
128MP0000266_abnormal_heart_morphology0.79830646
129MP0005083_abnormal_biliary_tract0.79260648
130MP0002152_abnormal_brain_morphology0.79091300
131MP0000350_abnormal_cell_proliferation0.78872279
132MP0005394_taste/olfaction_phenotype0.78788720
133MP0005499_abnormal_olfactory_system0.78788720
134MP0002998_abnormal_bone_remodeling0.77962282
135MP0001873_stomach_inflammation0.77840931
136MP0003633_abnormal_nervous_system0.76676712
137MP0010678_abnormal_skin_adnexa0.76587478
138MP0002086_abnormal_extraembryonic_tissu0.76382734
139MP0001784_abnormal_fluid_regulation0.75678588
140MP0001672_abnormal_embryogenesis/_devel0.75152454
141MP0005380_embryogenesis_phenotype0.75152454
142MP0000689_abnormal_spleen_morphology0.74107742
143MP0000955_abnormal_spinal_cord0.73802394
144MP0000716_abnormal_immune_system0.73712366
145MP0002108_abnormal_muscle_morphology0.73435391
146MP0005670_abnormal_white_adipose0.73354433
147MP0001486_abnormal_startle_reflex0.73289214
148* MP0002064_seizures0.73114713
149MP0009672_abnormal_birth_weight0.72894530
150MP0005187_abnormal_penis_morphology0.72552623
151MP0005646_abnormal_pituitary_gland0.72191697
152MP0003436_decreased_susceptibility_to0.71942459
153MP0005621_abnormal_cell_physiology0.71702086
154MP0002085_abnormal_embryonic_tissue0.71560266
155MP0005448_abnormal_energy_balance0.71495517
156MP0002118_abnormal_lipid_homeostasis0.71365564
157MP0001851_eye_inflammation0.71207810
158MP0003329_amyloid_beta_deposits0.71175516
159* MP0009745_abnormal_behavioral_response0.71040111
160MP0002876_abnormal_thyroid_physiology0.70421332
161MP0000465_gastrointestinal_hemorrhage0.70343020
162MP0004084_abnormal_cardiac_muscle0.70222155
163MP0009703_decreased_birth_body0.70160401
164MP0000747_muscle_weakness0.69413470
165MP0000538_abnormal_urinary_bladder0.68910340
166MP0002229_neurodegeneration0.68662059
167MP0005000_abnormal_immune_tolerance0.67559115
168MP0005395_other_phenotype0.67370265
169MP0001664_abnormal_digestion0.67216836
170MP0002332_abnormal_exercise_endurance0.66418879
171MP0004924_abnormal_behavior0.66411096
172MP0005386_behavior/neurological_phenoty0.66411096
173MP0005266_abnormal_metabolism0.65487100

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)5.91066305
2Gaze-evoked nystagmus (HP:0000640)5.03187316
3Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.32604497
4Abnormality of the fingertips (HP:0001211)4.25205527
5Hyperventilation (HP:0002883)3.98007542
6Clumsiness (HP:0002312)3.94325553
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.90090487
8Hyperacusis (HP:0010780)3.80269767
9Prostate neoplasm (HP:0100787)3.34068658
10Protruding tongue (HP:0010808)3.30149210
11Increased cerebral lipofuscin (HP:0011813)3.26217569
12Cerebral aneurysm (HP:0004944)3.25322738
13Macroorchidism (HP:0000053)3.18190619
14Action tremor (HP:0002345)3.13496549
15Abnormality of the hepatic vasculature (HP:0006707)3.04313333
16Trigonocephaly (HP:0000243)2.78996604
17Neoplasm of the heart (HP:0100544)2.76397689
18Elfin facies (HP:0004428)2.76220156
19Insomnia (HP:0100785)2.71104593
20Fair hair (HP:0002286)2.67384534
21Visual hallucinations (HP:0002367)2.64214811
22Attenuation of retinal blood vessels (HP:0007843)2.63341399
23Pointed chin (HP:0000307)2.61475363
24Congenital sensorineural hearing impairment (HP:0008527)2.57199593
25Heterotopia (HP:0002282)2.57068748
26Febrile seizures (HP:0002373)2.55998856
27Facial diplegia (HP:0001349)2.53813282
28Short 4th metacarpal (HP:0010044)2.52998774
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52998774
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.50946178
31Congenital stationary night blindness (HP:0007642)2.48093171
32Ependymoma (HP:0002888)2.47861162
33Hypoplastic ischia (HP:0003175)2.46355842
34Absent speech (HP:0001344)2.45623209
35Renovascular hypertension (HP:0100817)2.45445146
36Long eyelashes (HP:0000527)2.43299849
37Abnormality of the lower motor neuron (HP:0002366)2.40940947
38Slow saccadic eye movements (HP:0000514)2.40560889
39Overriding aorta (HP:0002623)2.37635839
40Generalized hypopigmentation of hair (HP:0011358)2.37505622
41Astrocytoma (HP:0009592)2.36299296
42Abnormality of the astrocytes (HP:0100707)2.36299296
43Broad metatarsal (HP:0001783)2.35724603
44Impaired vibratory sensation (HP:0002495)2.33845760
45Severe visual impairment (HP:0001141)2.30050071
46Abnormality of ocular smooth pursuit (HP:0000617)2.29563862
47Abnormality of the ischium (HP:0003174)2.28113036
48Ileus (HP:0002595)2.25881509
49Pancreatic cysts (HP:0001737)2.25880347
50Hemiplegia (HP:0002301)2.24923877
51Narrow palate (HP:0000189)2.24864769
52Vertebral arch anomaly (HP:0008438)2.24456823
53Urethral obstruction (HP:0000796)2.23217532
54Hypochromic microcytic anemia (HP:0004840)2.23091503
55Distal upper limb amyotrophy (HP:0007149)2.22705114
56Upper limb amyotrophy (HP:0009129)2.22705114
57Obsessive-compulsive behavior (HP:0000722)2.22244180
58Anal stenosis (HP:0002025)2.21235932
59Dysmetric saccades (HP:0000641)2.16060740
60Flat cornea (HP:0007720)2.15980354
61Chronic hepatic failure (HP:0100626)2.13460916
62Turricephaly (HP:0000262)2.13392192
63Ulnar bowing (HP:0003031)2.13250447
64Widely spaced teeth (HP:0000687)2.10783889
65Dysdiadochokinesis (HP:0002075)2.09564138
66Abnormality of binocular vision (HP:0011514)2.04663054
67Diplopia (HP:0000651)2.04663054
68Blue irides (HP:0000635)2.04662596
69Bowel diverticulosis (HP:0005222)2.04497357
70Genetic anticipation (HP:0003743)2.04361395
71Bony spicule pigmentary retinopathy (HP:0007737)2.03359233
72Hypochromic anemia (HP:0001931)2.02343732
73Shallow orbits (HP:0000586)2.02186576
74Central scotoma (HP:0000603)2.02152937
75Hyperkalemia (HP:0002153)2.01860444
76Colitis (HP:0002583)1.98340378
77Limited elbow extension (HP:0001377)1.97189859
78Renal duplication (HP:0000075)1.96615094
79Hand muscle atrophy (HP:0009130)1.95568078
80Portal hypertension (HP:0001409)1.94942934
81Decreased circulating renin level (HP:0003351)1.93801147
82Pseudobulbar signs (HP:0002200)1.93344265
83Aqueductal stenosis (HP:0002410)1.91336146
84Autoimmune thrombocytopenia (HP:0001973)1.90145276
85Cystic liver disease (HP:0006706)1.89457171
86Aneurysm (HP:0002617)1.88247320
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87953586
88Abnormality of the 4th metacarpal (HP:0010012)1.86547267
89Long toe (HP:0010511)1.85676291
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85214612
91Limb ataxia (HP:0002070)1.84233279
92T lymphocytopenia (HP:0005403)1.83816313
93Increased nuchal translucency (HP:0010880)1.83023358
94Prominent nose (HP:0000448)1.82040351
95Recurrent fungal infections (HP:0002841)1.81832132
96Verrucae (HP:0200043)1.81776296
97Papilloma (HP:0012740)1.81776296
98Gastrointestinal inflammation (HP:0004386)1.80347553
99Depressed nasal tip (HP:0000437)1.79796870
100Urinary urgency (HP:0000012)1.79403626
101Keratoconus (HP:0000563)1.79086299
102Increased corneal curvature (HP:0100692)1.79086299
103Difficulty running (HP:0009046)1.78620088
104Truncal obesity (HP:0001956)1.77924754
105Abnormality of the prostate (HP:0008775)1.77877192
106Lower limb amyotrophy (HP:0007210)1.77588297
107Abnormal social behavior (HP:0012433)1.76702170
108Impaired social interactions (HP:0000735)1.76702170
109Onion bulb formation (HP:0003383)1.76453681
110Pustule (HP:0200039)1.76221243
111Disproportionate tall stature (HP:0001519)1.75977723
112Abnormality of oral frenula (HP:0000190)1.75820865
113Chronic mucocutaneous candidiasis (HP:0002728)1.75815141
114Recurrent cutaneous fungal infections (HP:0011370)1.75815141
115Areflexia of lower limbs (HP:0002522)1.75342412
116Broad thumb (HP:0011304)1.74679713
117Macroglossia (HP:0000158)1.74674541
118Macular degeneration (HP:0000608)1.73842275
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.72818860
120Glioma (HP:0009733)1.72572022
121Abnormality of the renal cortex (HP:0011035)1.72274794
122Urinary bladder sphincter dysfunction (HP:0002839)1.71521730
123Ankyloglossia (HP:0010296)1.70387151
124Lymphangioma (HP:0100764)1.70273335
125Long palpebral fissure (HP:0000637)1.69715033
126Mitral valve prolapse (HP:0001634)1.68990133
127Spontaneous hematomas (HP:0007420)1.68265092
128Tracheomalacia (HP:0002779)1.68066128
129Abnormality of the nasal septum (HP:0000419)1.68026799
130Tapered finger (HP:0001182)1.67637315
131Hypoplastic iliac wings (HP:0002866)1.67080112
132Sandal gap (HP:0001852)1.66466141
133Stomach cancer (HP:0012126)1.66324608
134Bronchomalacia (HP:0002780)1.65637708
135Hypopigmentation of the fundus (HP:0007894)1.65111894
136Supranuclear gaze palsy (HP:0000605)1.64807511
137Inflammation of the large intestine (HP:0002037)1.64470211
138Tubular atrophy (HP:0000092)1.64406338
139Skin tags (HP:0010609)1.64196235
140Bulbous nose (HP:0000414)1.64023139
141Absent frontal sinuses (HP:0002688)1.64001498
142Focal motor seizures (HP:0011153)1.63749029
143Open mouth (HP:0000194)1.62274132
144Abnormality of T cell number (HP:0011839)1.61305810
145Gingival bleeding (HP:0000225)1.60743491
146Recurrent viral infections (HP:0004429)1.60741443
147Polydipsia (HP:0001959)1.60725080
148Abnormal drinking behavior (HP:0030082)1.60725080
149Broad-based gait (HP:0002136)1.60314536
150Dilatation of the ascending aorta (HP:0005111)1.60020286
151Lip pit (HP:0100267)1.59493226
152Megalocornea (HP:0000485)1.59195958
153Aortic aneurysm (HP:0004942)1.58986019
154Chronic diarrhea (HP:0002028)1.58637488
155Recurrent bacterial skin infections (HP:0005406)1.57615508
156Thick eyebrow (HP:0000574)1.57342847
157Large earlobe (HP:0009748)1.56480032
158Pancreatic fibrosis (HP:0100732)1.55968336
159* Focal seizures (HP:0007359)1.55646785
160Hematochezia (HP:0002573)1.55379706
161Attention deficit hyperactivity disorder (HP:0007018)1.54314644
162Increased density of long bones (HP:0006392)1.54252765
163Frequent falls (HP:0002359)1.53769270
164Arnold-Chiari malformation (HP:0002308)1.53401459
165Precocious puberty (HP:0000826)1.52384530
166Broad palm (HP:0001169)1.52314030
167Short chin (HP:0000331)1.52191313
168Tented upper lip vermilion (HP:0010804)1.52139631
169Cellulitis (HP:0100658)1.50898083
170Impaired smooth pursuit (HP:0007772)1.50722546
171Difficulty walking (HP:0002355)1.50514355
172Abnormality of saccadic eye movements (HP:0000570)1.49902160
173Autoimmune hemolytic anemia (HP:0001890)1.49253517
174Interstitial pulmonary disease (HP:0006530)1.48829413
175Rapidly progressive (HP:0003678)1.48698552
176Oligodontia (HP:0000677)1.48696819
177Sacral dimple (HP:0000960)1.48104891
178Mask-like facies (HP:0000298)1.47948274
179Postural instability (HP:0002172)1.47810551
180Spastic gait (HP:0002064)1.47504951
181Abnormality of the renal medulla (HP:0100957)1.47250217
182Abnormality of the sella turcica (HP:0002679)1.46918263
183Hemoptysis (HP:0002105)1.46413426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.70185211
2CDK123.74851869
3MAP3K103.39863363
4ACVR1B3.21435907
5EEF2K3.08866889
6TRIB32.78307204
7SIK22.63409031
8RIPK12.33293836
9ICK2.31116922
10PKN22.29926655
11BRD42.18337730
12CAMK1G2.17484379
13MAP4K12.06340193
14MAP3K71.90111678
15OXSR11.83132269
16CDK191.80868877
17FGFR21.78874694
18BLK1.78094980
19BMPR1B1.75876312
20TYRO31.74700578
21MAP3K91.72976722
22CAMK1D1.71747805
23SIK11.70090309
24AKT31.62693604
25TTN1.52301310
26PDGFRA1.46419450
27TXK1.44168060
28PIK3CG1.41541839
29DAPK21.41066973
30MARK21.40394459
31FGFR41.40010599
32PTK61.39698046
33ERN11.38683660
34MAP3K131.36187265
35EPHB11.36116054
36SIK31.33077210
37TAOK11.29073440
38NTRK21.26371274
39PRKCH1.25201314
40* MTOR1.23519450
41TRPM71.21071743
42ALK1.20227993
43FGFR31.14687094
44PRKAA21.11749060
45GRK61.08377677
46JAK11.07433593
47TEC1.07316830
48MELK1.06230385
49SGK31.05318847
50CDC42BPA1.02345088
51KSR11.01680897
52PAK61.01270566
53PTK2B0.99653835
54ADRBK20.99027818
55PRKD30.97844118
56INSRR0.97625092
57GRK10.97032143
58PDGFRB0.96527710
59KIT0.96525463
60CAMKK10.92322578
61NLK0.91912021
62FER0.90322549
63PDK10.89199144
64WNK10.87787156
65ITK0.87479636
66PRKD20.86004106
67RET0.83773352
68RPS6KA20.83481535
69MKNK20.83447470
70MAPK110.83311163
71DMPK0.83187264
72HCK0.82834187
73ERBB20.82018337
74STK110.80685693
75BMX0.79609498
76MARK30.79272235
77KSR20.78306487
78CLK10.78115956
79STK38L0.77153073
80NEK20.71877552
81ADRBK10.71592204
82CDK40.71028346
83SYK0.70932073
84MAPK130.69676311
85NTRK30.69528807
86PDPK10.68410078
87CDK60.67695737
88ZAP700.66696827
89FES0.66503212
90FGFR10.65003550
91LATS10.64930587
92CAMK40.63573576
93TNK20.63415189
94IKBKE0.62470382
95TGFBR10.61544703
96STK380.60982373
97IKBKB0.60723451
98STK100.60451543
99EPHA30.60419278
100LRRK20.59604665
101MAP3K40.59354869
102JAK30.59156723
103UHMK10.58207136
104PRKD10.58192677
105TYK20.58141478
106HIPK20.58030125
107CHUK0.56365952
108MAPK70.56201592
109SGK10.55629918
110CSF1R0.55314844
111MAP2K60.54916543
112MAPK120.53988193
113MAPK100.53327737
114PIK3CA0.53013998
115FYN0.52886569
116IRAK10.52149958
117JAK20.52141292
118LCK0.51600090
119CAMKK20.50867157
120CAMK10.50754755
121MAP2K30.49494499
122TAOK30.48568871
123PRKAA10.47440636
124PNCK0.47180789
125NTRK10.46959157
126SGK4940.46875359
127SGK2230.46875359
128CDK50.46768279
129PTK20.45895709
130MAP3K20.45759095
131MAPK80.45351325
132RPS6KA60.44932055
133EPHA40.44718263
134RPS6KA30.44713303
135SGK20.44643928
136DYRK1B0.44566210
137BTK0.43926577
138GSK3B0.43862090
139CDK90.43738161
140RIPK40.43666376
141CSNK1D0.43578498
142RPS6KC10.42799353
143RPS6KL10.42799353
144STK30.41260505
145PASK0.40917358
146RPS6KA10.40108190
147MAP3K140.38959131
148PINK10.37927857

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.16459988
2Lysine degradation_Homo sapiens_hsa003102.13125378
3mTOR signaling pathway_Homo sapiens_hsa041501.75152266
4B cell receptor signaling pathway_Homo sapiens_hsa046621.74810131
5Type II diabetes mellitus_Homo sapiens_hsa049301.65878054
6Chronic myeloid leukemia_Homo sapiens_hsa052201.58136900
7Thyroid hormone signaling pathway_Homo sapiens_hsa049191.51692958
8Notch signaling pathway_Homo sapiens_hsa043301.51678072
9Dorso-ventral axis formation_Homo sapiens_hsa043201.50222008
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44923050
11Non-small cell lung cancer_Homo sapiens_hsa052231.42889666
12T cell receptor signaling pathway_Homo sapiens_hsa046601.42861362
13Olfactory transduction_Homo sapiens_hsa047401.42672855
14Primary immunodeficiency_Homo sapiens_hsa053401.41024682
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39011031
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29338999
17Glioma_Homo sapiens_hsa052141.28533290
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27455022
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26768881
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.26615338
21Tryptophan metabolism_Homo sapiens_hsa003801.26477471
22Endometrial cancer_Homo sapiens_hsa052131.25982361
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24346451
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21613363
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.20332192
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17971370
27Graft-versus-host disease_Homo sapiens_hsa053321.17756884
28Acute myeloid leukemia_Homo sapiens_hsa052211.17018206
29ErbB signaling pathway_Homo sapiens_hsa040121.16770052
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16695752
31Salivary secretion_Homo sapiens_hsa049701.15676780
32Linoleic acid metabolism_Homo sapiens_hsa005911.15559124
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12076119
34Estrogen signaling pathway_Homo sapiens_hsa049151.10835578
35Circadian entrainment_Homo sapiens_hsa047131.10779488
36VEGF signaling pathway_Homo sapiens_hsa043701.10620013
37Gastric acid secretion_Homo sapiens_hsa049711.10253894
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.09598564
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09248160
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.09069831
41Oxytocin signaling pathway_Homo sapiens_hsa049211.08864907
42Morphine addiction_Homo sapiens_hsa050321.08778531
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.08187578
44Ether lipid metabolism_Homo sapiens_hsa005651.06793986
45Long-term potentiation_Homo sapiens_hsa047201.06368903
46GnRH signaling pathway_Homo sapiens_hsa049121.05600846
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.04081778
48Insulin resistance_Homo sapiens_hsa049311.03407956
49Ovarian steroidogenesis_Homo sapiens_hsa049131.02713243
50Colorectal cancer_Homo sapiens_hsa052101.02516604
51Glycerolipid metabolism_Homo sapiens_hsa005611.02317160
52Glutamatergic synapse_Homo sapiens_hsa047241.01946393
53Taste transduction_Homo sapiens_hsa047421.01698815
54Dilated cardiomyopathy_Homo sapiens_hsa054141.00269589
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99969706
56MicroRNAs in cancer_Homo sapiens_hsa052060.99904320
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99632714
58Inositol phosphate metabolism_Homo sapiens_hsa005620.99535702
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99417343
60Nitrogen metabolism_Homo sapiens_hsa009100.99131157
61Staphylococcus aureus infection_Homo sapiens_hsa051500.97741835
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.96755599
63Choline metabolism in cancer_Homo sapiens_hsa052310.96737843
64Fatty acid biosynthesis_Homo sapiens_hsa000610.96097721
65Proteoglycans in cancer_Homo sapiens_hsa052050.95876124
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95027441
67Pancreatic cancer_Homo sapiens_hsa052120.94264268
68Renal cell carcinoma_Homo sapiens_hsa052110.93887319
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93610642
70Axon guidance_Homo sapiens_hsa043600.93477309
71Osteoclast differentiation_Homo sapiens_hsa043800.92256471
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92232371
73Platelet activation_Homo sapiens_hsa046110.91812255
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91639177
75Cholinergic synapse_Homo sapiens_hsa047250.91588441
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.90482556
77Insulin signaling pathway_Homo sapiens_hsa049100.90160577
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89783336
79MAPK signaling pathway_Homo sapiens_hsa040100.89699861
80Chemokine signaling pathway_Homo sapiens_hsa040620.88967940
81Insulin secretion_Homo sapiens_hsa049110.88911220
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88773240
83Small cell lung cancer_Homo sapiens_hsa052220.87524102
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87469226
85Renin secretion_Homo sapiens_hsa049240.84861112
86Butanoate metabolism_Homo sapiens_hsa006500.84646134
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83292215
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.83160257
89cAMP signaling pathway_Homo sapiens_hsa040240.82591613
90GABAergic synapse_Homo sapiens_hsa047270.82549905
91Gap junction_Homo sapiens_hsa045400.81443737
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81126021
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80981653
94Focal adhesion_Homo sapiens_hsa045100.80769544
95Autoimmune thyroid disease_Homo sapiens_hsa053200.80093656
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.79521279
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79039090
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.79027289
99TNF signaling pathway_Homo sapiens_hsa046680.78350400
100AMPK signaling pathway_Homo sapiens_hsa041520.77613332
101Long-term depression_Homo sapiens_hsa047300.77146162
102Prolactin signaling pathway_Homo sapiens_hsa049170.76799412
103Allograft rejection_Homo sapiens_hsa053300.76696220
104Dopaminergic synapse_Homo sapiens_hsa047280.76256948
105Adherens junction_Homo sapiens_hsa045200.76041459
106Viral myocarditis_Homo sapiens_hsa054160.75576433
107HTLV-I infection_Homo sapiens_hsa051660.75086521
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74794915
109Circadian rhythm_Homo sapiens_hsa047100.74641571
110Basal cell carcinoma_Homo sapiens_hsa052170.73573311
111Histidine metabolism_Homo sapiens_hsa003400.73544360
112ABC transporters_Homo sapiens_hsa020100.72754248
113Rap1 signaling pathway_Homo sapiens_hsa040150.72278656
114Serotonergic synapse_Homo sapiens_hsa047260.72160556
115Sphingolipid metabolism_Homo sapiens_hsa006000.72112093
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.71270063
117Phototransduction_Homo sapiens_hsa047440.71204916
118mRNA surveillance pathway_Homo sapiens_hsa030150.68594073
119Endocytosis_Homo sapiens_hsa041440.68516190
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68183629
121Influenza A_Homo sapiens_hsa051640.67980585
122Nicotine addiction_Homo sapiens_hsa050330.67260104
123Cocaine addiction_Homo sapiens_hsa050300.67168402
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66710911
125FoxO signaling pathway_Homo sapiens_hsa040680.66129323
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66124172
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65543730
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64978999
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64052988
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63919929
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63111708
132Bile secretion_Homo sapiens_hsa049760.62870763
133Melanogenesis_Homo sapiens_hsa049160.62466492
134Hepatitis C_Homo sapiens_hsa051600.61888954
135Other glycan degradation_Homo sapiens_hsa005110.61627750
136Toxoplasmosis_Homo sapiens_hsa051450.61538207
137Calcium signaling pathway_Homo sapiens_hsa040200.59869735
138Glucagon signaling pathway_Homo sapiens_hsa049220.59502222
139Hepatitis B_Homo sapiens_hsa051610.59337512
140Synaptic vesicle cycle_Homo sapiens_hsa047210.58279950
141Leishmaniasis_Homo sapiens_hsa051400.56621362
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56029093
143Tuberculosis_Homo sapiens_hsa051520.55137266
144Retinol metabolism_Homo sapiens_hsa008300.54570400
145Asthma_Homo sapiens_hsa053100.51931340
146African trypanosomiasis_Homo sapiens_hsa051430.50683975
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.50413698

Most similar genes based on co-expression Upload to Enrichr

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