T

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in gastrulation (GO:0042074)8.12295857
2regulation of posttranscriptional gene silencing (GO:0060147)6.77023943
3regulation of gene silencing by miRNA (GO:0060964)6.77023943
4regulation of gene silencing by RNA (GO:0060966)6.77023943
5regulation of mesoderm development (GO:2000380)6.20197935
6pre-miRNA processing (GO:0031054)6.01407213
7establishment of integrated proviral latency (GO:0075713)5.48383667
8nodal signaling pathway (GO:0038092)5.36563154
9paraxial mesoderm development (GO:0048339)5.13044502
10* signal transduction involved in regulation of gene expression (GO:0023019)5.10383783
11DNA unwinding involved in DNA replication (GO:0006268)5.08347873
12folic acid-containing compound biosynthetic process (GO:0009396)4.89118133
13mitotic sister chromatid cohesion (GO:0007064)4.88477381
14protein localization to chromosome, centromeric region (GO:0071459)4.70154239
15lung morphogenesis (GO:0060425)4.66565871
16CENP-A containing nucleosome assembly (GO:0034080)4.50256647
17chromatin remodeling at centromere (GO:0031055)4.46683772
18heart field specification (GO:0003128)4.40056593
19secondary heart field specification (GO:0003139)4.40056593
20IMP biosynthetic process (GO:0006188)4.29797076
21epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.28254179
22nuclear pore organization (GO:0006999)4.22607825
23ribosome assembly (GO:0042255)4.21735627
24somatic hypermutation of immunoglobulin genes (GO:0016446)4.15077220
25somatic diversification of immune receptors via somatic mutation (GO:0002566)4.15077220
26mitotic chromosome condensation (GO:0007076)4.10574616
27otic vesicle formation (GO:0030916)4.09719324
28cellular protein complex localization (GO:0034629)4.09411641
29positive regulation of SMAD protein import into nucleus (GO:0060391)4.09031307
30establishment of viral latency (GO:0019043)4.01635706
31formation of translation preinitiation complex (GO:0001731)3.96374364
32regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.88463656
33DNA replication-dependent nucleosome organization (GO:0034723)3.85235715
34DNA replication-dependent nucleosome assembly (GO:0006335)3.85235715
35nuclear pore complex assembly (GO:0051292)3.82925414
36nucleobase biosynthetic process (GO:0046112)3.79608199
37IMP metabolic process (GO:0046040)3.79594350
38negative regulation of cell fate specification (GO:0009996)3.79591688
39DNA strand elongation involved in DNA replication (GO:0006271)3.77599592
40peptidyl-arginine omega-N-methylation (GO:0035247)3.71420288
41somite rostral/caudal axis specification (GO:0032525)3.71289245
42positive regulation of cell size (GO:0045793)3.70886518
43DNA replication initiation (GO:0006270)3.66700471
44gastrulation (GO:0007369)3.66000717
45DNA topological change (GO:0006265)3.65299253
46histone exchange (GO:0043486)3.63436728
47maturation of SSU-rRNA (GO:0030490)3.59362803
48negative regulation of androgen receptor signaling pathway (GO:0060766)3.59235250
49DNA replication-independent nucleosome organization (GO:0034724)3.57968233
50DNA replication-independent nucleosome assembly (GO:0006336)3.57968233
51transcription from mitochondrial promoter (GO:0006390)3.57658992
52mitotic nuclear envelope disassembly (GO:0007077)3.57280279
53DNA strand elongation (GO:0022616)3.54596760
54metaphase plate congression (GO:0051310)3.52668932
55histone arginine methylation (GO:0034969)3.48426306
56kinetochore organization (GO:0051383)3.48122688
57somatic recombination of immunoglobulin gene segments (GO:0016447)3.47251222
58ATP-dependent chromatin remodeling (GO:0043044)3.44154272
59ribosomal large subunit biogenesis (GO:0042273)3.43098775
60regulation of centriole replication (GO:0046599)3.38210190
61telomere maintenance via recombination (GO:0000722)3.37825499
62regulation of SMAD protein import into nucleus (GO:0060390)3.37393984
63somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.37116449
64somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.37116449
65isotype switching (GO:0045190)3.37116449
66heterochromatin organization (GO:0070828)3.37060811
67sister chromatid segregation (GO:0000819)3.36968910
68polarized epithelial cell differentiation (GO:0030859)3.32924513
69purine nucleobase biosynthetic process (GO:0009113)3.32008001
70membrane disassembly (GO:0030397)3.29879051
71nuclear envelope disassembly (GO:0051081)3.29879051
72establishment of chromosome localization (GO:0051303)3.29001203
73cell fate commitment involved in formation of primary germ layer (GO:0060795)3.26526615
74chromatin assembly or disassembly (GO:0006333)3.25352430
75DNA replication checkpoint (GO:0000076)3.24522702
76notochord development (GO:0030903)3.23015420
77regulation of gene silencing (GO:0060968)3.20270208
78negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.20226324
79mitotic recombination (GO:0006312)3.19599296
80regulation of translational termination (GO:0006449)3.19572044
81viral transcription (GO:0019083)3.18025793
82termination of RNA polymerase II transcription (GO:0006369)3.17188191
83somatic cell DNA recombination (GO:0016444)3.16018251
84somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.16018251
85translational termination (GO:0006415)3.15049296
86mitochondrial RNA metabolic process (GO:0000959)3.14969594
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14449301
88ribosome biogenesis (GO:0042254)3.14280584
89protein localization to kinetochore (GO:0034501)3.13068232
90kinetochore assembly (GO:0051382)3.11741475
91ribonucleoprotein complex biogenesis (GO:0022613)3.10872168
92establishment of apical/basal cell polarity (GO:0035089)3.10846695
93DNA ligation (GO:0006266)3.10328045
94spliceosomal snRNP assembly (GO:0000387)3.09973891
95regulation of DNA endoreduplication (GO:0032875)3.09265814
96regulation of histone H3-K9 methylation (GO:0051570)3.09170820
97DNA geometric change (GO:0032392)3.09077770
98DNA duplex unwinding (GO:0032508)3.08998664
99regulation of centrosome cycle (GO:0046605)3.07981526
100spliceosomal complex assembly (GO:0000245)3.06851787
101somatic diversification of immunoglobulins (GO:0016445)3.06143212
102positive regulation of chromosome segregation (GO:0051984)3.05550902
103peptidyl-arginine N-methylation (GO:0035246)3.05134196
104peptidyl-arginine methylation (GO:0018216)3.05134196
105cell surface receptor signaling pathway involved in heart development (GO:0061311)3.03229478
106sister chromatid cohesion (GO:0007062)3.02566693
107translational initiation (GO:0006413)3.02481615
108double-strand break repair via nonhomologous end joining (GO:0006303)3.01947642
109non-recombinational repair (GO:0000726)3.01947642
110chromatin assembly (GO:0031497)3.00014020
111branching involved in salivary gland morphogenesis (GO:0060445)2.99858304
112mitotic metaphase plate congression (GO:0007080)2.99615259
113translational elongation (GO:0006414)2.98325868
114regulation of gastrulation (GO:0010470)2.98281231
115cell migration involved in heart development (GO:0060973)2.96244045
116ribosomal small subunit biogenesis (GO:0042274)2.95205713
117embryonic process involved in female pregnancy (GO:0060136)2.94824307
118telomere maintenance via semi-conservative replication (GO:0032201)2.94456181
119regulation of cell fate specification (GO:0042659)2.94437292
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93541991
121mitotic G2/M transition checkpoint (GO:0044818)2.92152949
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91891802
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91891802
124protein complex localization (GO:0031503)2.91862977
125positive regulation of catenin import into nucleus (GO:0035413)2.90676673
126regulation of translational fidelity (GO:0006450)2.89702646
127ncRNA catabolic process (GO:0034661)2.89141419
128somatic diversification of immune receptors (GO:0002200)2.88931880
129negative regulation of mRNA metabolic process (GO:1903312)2.87699298
130regulation of chromosome segregation (GO:0051983)2.86491629
131regulation of centrosome duplication (GO:0010824)2.86171401
132ribosomal small subunit assembly (GO:0000028)2.85640775
133pteridine-containing compound biosynthetic process (GO:0042559)2.85513201
134regulation of helicase activity (GO:0051095)2.84954660
135translesion synthesis (GO:0019985)2.84429368
136regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83895839
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.83556156
138positive regulation of cell cycle checkpoint (GO:1901978)2.82461166
139nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81653131
140tetrahydrofolate metabolic process (GO:0046653)2.81190542
141negative regulation of gene silencing (GO:0060969)2.81017595
142regulation of chromatin binding (GO:0035561)2.80178384
143mitotic sister chromatid segregation (GO:0000070)2.79886267
144single strand break repair (GO:0000012)2.78238307
145pore complex assembly (GO:0046931)2.76970899
146* morphogenesis of embryonic epithelium (GO:0016331)2.76729429
147organ induction (GO:0001759)2.76720897
148regulation of spindle organization (GO:0090224)2.74050782
149regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.73217024
150RNA splicing, via transesterification reactions (GO:0000375)2.69614821
151RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.68678554
152mRNA splicing, via spliceosome (GO:0000398)2.68678554
153negative regulation of chromosome segregation (GO:0051985)2.66338442
154rRNA processing (GO:0006364)2.66043595
155trophectodermal cell differentiation (GO:0001829)2.64010383
156regulation of telomere maintenance via telomerase (GO:0032210)2.63903210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.51293396
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.76935588
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.48533888
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45164437
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38024806
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.16997306
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96287064
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69792331
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69530402
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69530402
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69530402
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.67294587
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64921258
14XRN2_22483619_ChIP-Seq_HELA_Human2.56203609
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51267537
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.50930882
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.50170279
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.47037106
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34463723
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.21864038
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.20115316
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.16779137
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16383907
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.15830655
25AR_21909140_ChIP-Seq_LNCAP_Human2.14391001
26* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.08918756
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05959058
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03847635
29TP63_17297297_ChIP-ChIP_HaCaT_Human2.01071940
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98581802
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98224742
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97519709
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92609325
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91270225
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90688124
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89357062
37* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88713282
38TTF2_22483619_ChIP-Seq_HELA_Human1.88113008
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87383671
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85616788
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77646103
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76030506
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.75117098
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.72901460
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71315171
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71118266
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66971657
48MYC_22102868_ChIP-Seq_BL_Human1.63634527
49SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.60547308
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60076473
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59756209
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59473919
53CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.51560183
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50440294
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50104981
56* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49526354
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.47554425
58* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.44802424
59* NANOG_16153702_ChIP-ChIP_HESCs_Human1.44796924
60* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44209663
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43282047
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39420450
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38846129
64DCP1A_22483619_ChIP-Seq_HELA_Human1.38165054
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38081434
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37788750
67* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37484402
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36845591
69VDR_23849224_ChIP-Seq_CD4+_Human1.36780141
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36221730
71* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34633906
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33033757
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32742212
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32509492
75* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29784054
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29452826
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29416559
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29364407
79FOXP3_21729870_ChIP-Seq_TREG_Human1.29157540
80* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28544076
81GABP_19822575_ChIP-Seq_HepG2_Human1.28294640
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25745471
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25541919
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24891469
85TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24107975
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23490717
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23384781
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22557230
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.21510014
90* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21360183
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.20541761
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19148544
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18529156
94KDM5A_27292631_Chip-Seq_BREAST_Human1.17478966
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17438344
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17318911
97MYC_18940864_ChIP-ChIP_HL60_Human1.17026513
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14983513
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14580208
100* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14022632
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13814043
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12932737
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.11579769
104VDR_21846776_ChIP-Seq_THP-1_Human1.11227145
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09163264
106ELK1_19687146_ChIP-ChIP_HELA_Human1.08524037
107* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08371739
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08193888
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07807872
110CIITA_25753668_ChIP-Seq_RAJI_Human1.07600835
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07466015
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06485115
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05906821
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05629799
115* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04988282
116* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03374205
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02082503
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01100586
119* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99902248
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98781363
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98227208
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98183410
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97592255
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92944116
125TFEB_21752829_ChIP-Seq_HELA_Human0.90511803
126GATA1_26923725_Chip-Seq_HPCs_Mouse0.89582050
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89158439
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85877378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004133_heterotaxia4.80552747
2MP0003890_abnormal_embryonic-extraembry4.42954991
3MP0010030_abnormal_orbit_morphology3.84099604
4MP0004957_abnormal_blastocyst_morpholog3.60320777
5MP0005645_abnormal_hypothalamus_physiol3.35640877
6MP0003123_paternal_imprinting3.27275948
7MP0002254_reproductive_system_inflammat3.18487696
8MP0003693_abnormal_embryo_hatching3.15938667
9MP0003119_abnormal_digestive_system2.97440951
10MP0008057_abnormal_DNA_replication2.81723574
11MP0003077_abnormal_cell_cycle2.81672425
12MP0008932_abnormal_embryonic_tissue2.66124628
13MP0010094_abnormal_chromosome_stability2.61370121
14MP0001730_embryonic_growth_arrest2.58829581
15MP0003111_abnormal_nucleus_morphology2.48834720
16MP0002653_abnormal_ependyma_morphology2.46327419
17MP0002084_abnormal_developmental_patter2.40529197
18MP0003937_abnormal_limbs/digits/tail_de2.36207930
19MP0000678_abnormal_parathyroid_gland2.29422485
20MP0010352_gastrointestinal_tract_polyps2.15748355
21MP0001672_abnormal_embryogenesis/_devel2.12859003
22MP0005380_embryogenesis_phenotype2.12859003
23MP0002234_abnormal_pharynx_morphology2.10257222
24MP0004197_abnormal_fetal_growth/weight/2.09291265
25* MP0002111_abnormal_tail_morphology2.07733492
26MP0000490_abnormal_crypts_of2.05593492
27MP0002085_abnormal_embryonic_tissue2.01039370
28MP0003283_abnormal_digestive_organ2.00185029
29MP0008007_abnormal_cellular_replicative1.97875253
30MP0001697_abnormal_embryo_size1.92699366
31MP0005623_abnormal_meninges_morphology1.90329531
32MP0008058_abnormal_DNA_repair1.88229570
33MP0000350_abnormal_cell_proliferation1.88006176
34MP0003121_genomic_imprinting1.81952680
35MP0001293_anophthalmia1.80249668
36MP0003806_abnormal_nucleotide_metabolis1.78018753
37MP0008877_abnormal_DNA_methylation1.75370316
38MP0009053_abnormal_anal_canal1.73582614
39MP0000685_abnormal_immune_system1.71805264
40MP0003984_embryonic_growth_retardation1.70756176
41MP0002088_abnormal_embryonic_growth/wei1.69249426
42MP0000049_abnormal_middle_ear1.67180148
43MP0000537_abnormal_urethra_morphology1.66598695
44MP0000428_abnormal_craniofacial_morphol1.63749855
45MP0010307_abnormal_tumor_latency1.62626887
46MP0002080_prenatal_lethality1.53869031
47MP0002086_abnormal_extraembryonic_tissu1.53666547
48MP0003941_abnormal_skin_development1.53121232
49MP0002932_abnormal_joint_morphology1.50964877
50MP0002160_abnormal_reproductive_system1.50300929
51MP0001727_abnormal_embryo_implantation1.45116110
52MP0003942_abnormal_urinary_system1.44374226
53MP0009672_abnormal_birth_weight1.44266037
54MP0001790_abnormal_immune_system1.43814059
55MP0005387_immune_system_phenotype1.43814059
56MP0002009_preneoplasia1.37541772
57MP0000432_abnormal_head_morphology1.37407357
58MP0005671_abnormal_response_to1.36582698
59MP0003385_abnormal_body_wall1.33970381
60MP0003763_abnormal_thymus_physiology1.33332766
61MP0003935_abnormal_craniofacial_develop1.30853840
62MP0004185_abnormal_adipocyte_glucose1.30701691
63MP0001800_abnormal_humoral_immune1.30025913
64MP0003861_abnormal_nervous_system1.24313319
65MP0005394_taste/olfaction_phenotype1.22939306
66MP0005499_abnormal_olfactory_system1.22939306
67MP0004808_abnormal_hematopoietic_stem1.18390992
68MP0002398_abnormal_bone_marrow1.17526246
69MP0009703_decreased_birth_body1.14750715
70MP0008789_abnormal_olfactory_epithelium1.13471737
71MP0003315_abnormal_perineum_morphology1.11955770
72MP0002796_impaired_skin_barrier1.09409128
73MP0003221_abnormal_cardiomyocyte_apopto1.09339811
74MP0006035_abnormal_mitochondrial_morpho1.08500720
75MP0002163_abnormal_gland_morphology1.08307617
76MP0002019_abnormal_tumor_incidence1.07818871
77MP0002166_altered_tumor_susceptibility1.06269915
78MP0005076_abnormal_cell_differentiation1.04849279
79MP0001286_abnormal_eye_development1.04767500
80MP0003122_maternal_imprinting1.03447620
81MP0002114_abnormal_axial_skeleton1.03234421
82MP0006072_abnormal_retinal_apoptosis1.01006839
83MP0002396_abnormal_hematopoietic_system0.99595944
84MP0004233_abnormal_muscle_weight0.98998787
85MP0002925_abnormal_cardiovascular_devel0.98888468
86MP0002332_abnormal_exercise_endurance0.98694073
87MP0000689_abnormal_spleen_morphology0.97943245
88MP0003567_abnormal_fetal_cardiomyocyte0.97444141
89MP0000313_abnormal_cell_death0.95681576
90MP0002092_abnormal_eye_morphology0.94021182
91MP0002877_abnormal_melanocyte_morpholog0.92774270
92MP0003566_abnormal_cell_adhesion0.92756124
93MP0000703_abnormal_thymus_morphology0.91873747
94MP0000733_abnormal_muscle_development0.91725592
95MP0002697_abnormal_eye_size0.91326032
96MP0002127_abnormal_cardiovascular_syste0.91181083
97MP0002138_abnormal_hepatobiliary_system0.87719681
98MP0006292_abnormal_olfactory_placode0.87336493
99MP0005621_abnormal_cell_physiology0.87320510
100MP0001348_abnormal_lacrimal_gland0.86898707
101MP0002116_abnormal_craniofacial_bone0.85729464
102MP0002177_abnormal_outer_ear0.85629643
103MP0002098_abnormal_vibrissa_morphology0.83828228
104MP0000358_abnormal_cell_content/0.83612817
105MP0002006_tumorigenesis0.83161917
106MP0002233_abnormal_nose_morphology0.82541620
107MP0009384_cardiac_valve_regurgitation0.82268873
108MP0000631_abnormal_neuroendocrine_gland0.81799907
109MP0002722_abnormal_immune_system0.81652001
110MP0003755_abnormal_palate_morphology0.80927770
111MP0002249_abnormal_larynx_morphology0.80714776
112MP0000762_abnormal_tongue_morphology0.80140607
113MP0005266_abnormal_metabolism0.80039296
114MP0000716_abnormal_immune_system0.79443442
115MP0002210_abnormal_sex_determination0.78939261
116MP0002429_abnormal_blood_cell0.78600544
117MP0000534_abnormal_ureter_morphology0.78047091
118MP0001661_extended_life_span0.77580993
119MP0002452_abnormal_antigen_presenting0.77434018
120MP0008260_abnormal_autophagy0.77428904
121MP0004264_abnormal_extraembryonic_tissu0.77028930
122MP0001835_abnormal_antigen_presentation0.76631104
123MP0003115_abnormal_respiratory_system0.76423574
124MP0001915_intracranial_hemorrhage0.74731634
125MP0003705_abnormal_hypodermis_morpholog0.74675358
126MP0005501_abnormal_skin_physiology0.74383814
127MP0002089_abnormal_postnatal_growth/wei0.74379778
128MP0005389_reproductive_system_phenotype0.74207376
129MP0001849_ear_inflammation0.73358554
130MP0000516_abnormal_urinary_system0.72207716
131MP0005367_renal/urinary_system_phenotyp0.72207716
132MP0003786_premature_aging0.71762142
133MP0001145_abnormal_male_reproductive0.69416831
134MP0009697_abnormal_copulation0.69159767
135MP0003938_abnormal_ear_development0.68942749
136MP0009333_abnormal_splenocyte_physiolog0.68894570
137MP0000750_abnormal_muscle_regeneration0.68884639
138MP0000266_abnormal_heart_morphology0.67371079
139MP0005000_abnormal_immune_tolerance0.66902700
140MP0001929_abnormal_gametogenesis0.63979246
141MP0002081_perinatal_lethality0.63296581
142MP0002420_abnormal_adaptive_immunity0.62935112
143MP0003718_maternal_effect0.62869590
144MP0005384_cellular_phenotype0.61151375
145MP0005391_vision/eye_phenotype0.61089424
146MP0003878_abnormal_ear_physiology0.60750109
147MP0005377_hearing/vestibular/ear_phenot0.60750109
148MP0001819_abnormal_immune_cell0.60233507
149MP0003936_abnormal_reproductive_system0.60148022
150MP0010234_abnormal_vibrissa_follicle0.59489657

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.87160435
2Abnormality of abdominal situs (HP:0011620)4.78482923
3Abdominal situs inversus (HP:0003363)4.78482923
4Gastrointestinal stroma tumor (HP:0100723)4.78035874
5Colon cancer (HP:0003003)4.52433149
6Cortical dysplasia (HP:0002539)4.05888389
7IgA deficiency (HP:0002720)3.86351065
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.77707239
9Breast aplasia (HP:0100783)3.76467657
10Aplasia/hypoplasia of the humerus (HP:0006507)3.75830793
11Asplenia (HP:0001746)3.58592015
12Short humerus (HP:0005792)3.51882373
13Aplasia/Hypoplasia of the breasts (HP:0010311)3.40767889
14Supernumerary spleens (HP:0009799)3.32484658
15Aplasia/Hypoplasia of the spleen (HP:0010451)3.32311516
16Agammaglobulinemia (HP:0004432)3.25813064
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19613823
18Recurrent sinusitis (HP:0011108)3.18110946
19Abnormal lung lobation (HP:0002101)3.17949273
20IgM deficiency (HP:0002850)3.17461421
21Selective tooth agenesis (HP:0001592)3.16419853
22Absent radius (HP:0003974)3.15449226
23Ependymoma (HP:0002888)3.03195222
24Dry hair (HP:0011359)3.01592352
25Birth length less than 3rd percentile (HP:0003561)3.01400238
26Aplasia involving forearm bones (HP:0009822)2.98142481
27Absent forearm bone (HP:0003953)2.98142481
28Abnormal number of incisors (HP:0011064)2.96784390
29Chromsome breakage (HP:0040012)2.95381200
30Preauricular skin tag (HP:0000384)2.94183819
31Microvesicular hepatic steatosis (HP:0001414)2.87766312
32Anal stenosis (HP:0002025)2.86857517
33Shawl scrotum (HP:0000049)2.85846819
34Deviation of the thumb (HP:0009603)2.82962674
35Vertebral fusion (HP:0002948)2.80078289
36Renal duplication (HP:0000075)2.78727044
37Medulloblastoma (HP:0002885)2.78300775
38Fused cervical vertebrae (HP:0002949)2.74845904
39Skin tags (HP:0010609)2.74340379
40Trismus (HP:0000211)2.70954612
41Abnormality of chromosome stability (HP:0003220)2.69392931
42Proximal placement of thumb (HP:0009623)2.69381718
43Missing ribs (HP:0000921)2.68459354
44Lymphopenia (HP:0001888)2.68271395
45Abnormality of the umbilical cord (HP:0010881)2.67419945
46Hemivertebrae (HP:0002937)2.62696714
47Rectovaginal fistula (HP:0000143)2.61632999
48Rectal fistula (HP:0100590)2.61632999
49Septo-optic dysplasia (HP:0100842)2.57577113
50Short middle phalanx of the 5th finger (HP:0004220)2.57393263
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.55967673
52Hypoplastic pelvis (HP:0008839)2.53508182
53Oral leukoplakia (HP:0002745)2.52838437
54Erectile abnormalities (HP:0100639)2.50654827
55Embryonal renal neoplasm (HP:0011794)2.49329807
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.47559765
57Reticulocytopenia (HP:0001896)2.45790933
58Long palpebral fissure (HP:0000637)2.44991922
59Abnormal umbilical cord blood vessels (HP:0011403)2.43163116
60Single umbilical artery (HP:0001195)2.43163116
61Abnormality of the fetal cardiovascular system (HP:0010948)2.43163116
62Squamous cell carcinoma (HP:0002860)2.40755444
63Meckel diverticulum (HP:0002245)2.39620936
64Broad thumb (HP:0011304)2.38042016
65Intestinal atresia (HP:0011100)2.37669047
66Long eyelashes (HP:0000527)2.36257178
67Back pain (HP:0003418)2.35963342
68Bifid tongue (HP:0010297)2.34282928
69Stenosis of the external auditory canal (HP:0000402)2.33647232
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.32804137
71Abnormality of the labia minora (HP:0012880)2.31245969
72Agnosia (HP:0010524)2.29074155
73Vaginal fistula (HP:0004320)2.27567377
74Facial cleft (HP:0002006)2.26712076
75Carpal bone hypoplasia (HP:0001498)2.22395569
76Abnormality of the ileum (HP:0001549)2.21775525
77Pseudobulbar signs (HP:0002200)2.21547167
78Intestinal fistula (HP:0100819)2.21514377
79Myelomeningocele (HP:0002475)2.18995707
80Basal cell carcinoma (HP:0002671)2.18694029
81Abnormality of the preputium (HP:0100587)2.17985190
82Atresia of the external auditory canal (HP:0000413)2.14710995
83Cellular immunodeficiency (HP:0005374)2.14699122
84Gonadotropin excess (HP:0000837)2.14496612
85Patellar aplasia (HP:0006443)2.14325042
86Lymphoma (HP:0002665)2.14249942
87Breast hypoplasia (HP:0003187)2.14212710
88Recurrent bronchitis (HP:0002837)2.13567563
89Horseshoe kidney (HP:0000085)2.13011903
90Cleft eyelid (HP:0000625)2.12068300
91Abnormality of the duodenum (HP:0002246)2.09167099
92Anal atresia (HP:0002023)2.09152419
93IgG deficiency (HP:0004315)2.07609951
94Increased nuchal translucency (HP:0010880)2.06211172
95Multiple enchondromatosis (HP:0005701)2.05696611
96Aplasia/Hypoplasia of the patella (HP:0006498)2.05262312
9711 pairs of ribs (HP:0000878)2.04909585
98Abnormal pancreas size (HP:0012094)2.04757455
99Neoplasm of the pancreas (HP:0002894)2.04747389
100Recurrent lower respiratory tract infections (HP:0002783)2.03201004
101Gastrointestinal carcinoma (HP:0002672)2.02240450
102Malignant gastrointestinal tract tumors (HP:0006749)2.02240450
103High anterior hairline (HP:0009890)2.00042352
104Small intestinal stenosis (HP:0012848)1.99741030
105Duodenal stenosis (HP:0100867)1.99741030
106Progressive muscle weakness (HP:0003323)1.97994628
107Volvulus (HP:0002580)1.94495323
108Broad phalanges of the hand (HP:0009768)1.94141003
109Abnormality of the anterior horn cell (HP:0006802)1.90530163
110Degeneration of anterior horn cells (HP:0002398)1.90530163
111Abnormality of the astrocytes (HP:0100707)1.88841469
112Astrocytoma (HP:0009592)1.88841469
113Hepatoblastoma (HP:0002884)1.88189756
114Abnormalities of placenta or umbilical cord (HP:0001194)1.86968440
115Short 4th metacarpal (HP:0010044)1.86142312
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86142312
117Tracheal stenosis (HP:0002777)1.85145499
118Supernumerary bones of the axial skeleton (HP:0009144)1.85035178
119Bilateral microphthalmos (HP:0007633)1.84960144
120Abnormality of cochlea (HP:0000375)1.84776817
121Abnormality of glycolysis (HP:0004366)1.84714464
122Increased serum pyruvate (HP:0003542)1.84714464
123Tracheoesophageal fistula (HP:0002575)1.84552482
124Hypoplastic labia majora (HP:0000059)1.84490626
125Absent thumb (HP:0009777)1.84355496
126Supernumerary ribs (HP:0005815)1.83598014
127Abnormal vertebral ossification (HP:0100569)1.82927003
128Abnormal ventriculo-arterial connection (HP:0011563)1.82345414
129Transposition of the great arteries (HP:0001669)1.82345414
130Abnormal connection of the cardiac segments (HP:0011545)1.82345414
131Biliary tract neoplasm (HP:0100574)1.80432467
132Recurrent viral infections (HP:0004429)1.80113560
133Impulsivity (HP:0100710)1.78206503
134Recurrent pneumonia (HP:0006532)1.77009342
135Carpal synostosis (HP:0009702)1.76857462
136Rocker bottom foot (HP:0001838)1.76450852
137Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75999753
138Aplastic anemia (HP:0001915)1.75881333
139Abnormality of pyrimidine metabolism (HP:0004353)1.74523586
140Trigonocephaly (HP:0000243)1.74295009
141Uterine neoplasm (HP:0010784)1.73581414
142Broad finger (HP:0001500)1.73150114
143Nephroblastoma (Wilms tumor) (HP:0002667)1.72154769
144Emphysema (HP:0002097)1.69849792
145Abnormality of the carotid arteries (HP:0005344)1.69779154
146Rhabdomyosarcoma (HP:0002859)1.64284386
147Leukopenia (HP:0001882)1.64132537
148Colitis (HP:0002583)1.63251993
149Hyperglycinemia (HP:0002154)1.62980671
150Hyperglycinuria (HP:0003108)1.62643811
151Deep philtrum (HP:0002002)1.61136278
152Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.60432042
153Ureteral duplication (HP:0000073)1.60125532
154Meningitis (HP:0001287)1.60051271
155Shoulder girdle muscle weakness (HP:0003547)1.58702781
156External ear malformation (HP:0008572)1.58122111
157Sloping forehead (HP:0000340)1.58108656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.47135189
2BUB14.32956718
3CDC74.09577750
4CDK123.73384706
5ZAK3.16508500
6TSSK63.13779515
7PASK2.95483040
8EPHA22.95439495
9PLK42.60965414
10MKNK12.38854851
11TESK22.17682057
12WEE12.10885206
13EIF2AK12.02978550
14BRD42.02825871
15MAP4K11.97984663
16TTK1.97703142
17PAK41.95296119
18SMG11.95210519
19RPS6KB21.91515744
20ALK1.87035628
21SRPK11.81079004
22TGFBR11.81066211
23NEK21.79911028
24CDK71.74245850
25MAP3K141.73438505
26TAF11.72337553
27PLK31.72293953
28STK241.70352436
29MAP3K101.68674037
30BRAF1.64307030
31MKNK21.64072178
32NEK11.60597988
33PLK11.53107594
34MAP3K81.37788092
35PNCK1.35258644
36AURKB1.33869116
37CHEK11.33335631
38ATR1.31126967
39MAP3K91.26158937
40STK101.26049706
41PRPF4B1.20699573
42TESK11.16546553
43VRK21.12723758
44VRK11.12415712
45AURKA1.11167988
46STK31.08628526
47FGFR11.06799218
48RPS6KA41.06319471
49NEK91.02990852
50TTN1.02490401
51LATS10.98272105
52RPS6KA50.98258563
53CDK60.97911844
54STK160.95144616
55CDK190.94802655
56CSNK1E0.92168425
57CDK20.91923221
58PIM10.91172608
59EEF2K0.90255666
60KDR0.89757939
61GRK60.88826802
62CDK40.88530165
63ATM0.87916558
64MAP2K20.87156660
65MTOR0.84592062
66TRIM280.84149140
67AKT20.83318833
68CSNK2A20.79367818
69CHEK20.79030196
70PAK10.77766414
71SIK30.77448107
72BMX0.75750897
73ICK0.70371689
74EIF2AK20.70144779
75DAPK10.69070976
76PLK20.66626917
77CDK10.65201175
78MELK0.64750769
79ACVR1B0.62456042
80TLK10.62174028
81BCR0.60098881
82SCYL20.59484532
83PAK20.58866303
84MAP3K130.58703092
85EIF2AK30.57179855
86SIK10.56620564
87CSNK2A10.56504477
88PRKDC0.53932188
89PTK60.52731880
90PRKCQ0.51782198
91STK40.51320952
92STK38L0.51208947
93DYRK20.51099365
94PBK0.51050328
95PDGFRA0.50654815
96PTK20.50020106
97DYRK30.49567250
98MAP3K40.48708339
99CDK140.47746381
100PRKD30.46508535
101RIPK40.46185572
102CDK30.45440715
103MAP3K110.42947472
104MAP2K30.42939968
105BRSK10.42335533
106BRSK20.41559867
107IRAK40.41506741
108CDK11A0.41389281
109CDK150.41358659
110LRRK20.41186651
111CDK80.40116938
112MST40.40023409
113CSF1R0.39699642
114DAPK30.37604259
115MET0.37469468
116TYRO30.36901261
117CDK180.36622837
118EPHB20.35609383
119YES10.35507976
120ERN10.34567453
121CDK90.34530676
122UHMK10.34034995
123BCKDK0.33736100
124PRKCH0.33735700
125RPS6KA10.33684799
126CSNK1D0.33362305
127LIMK10.31749715
128CCNB10.30717640
129BLK0.30567149
130CAMK1D0.29456281
131MAPK110.28857981
132NME10.28778419
133MAPK140.28532618
134ARAF0.28433890
135PRKCI0.28224420
136NME20.27828742
137GSK3B0.27218751
138CAMK1G0.26153893
139SIK20.25439025
140DAPK20.24595992
141CLK10.23971582

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.22767478
2Mismatch repair_Homo sapiens_hsa034304.16988575
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65064630
4Spliceosome_Homo sapiens_hsa030403.57240998
5One carbon pool by folate_Homo sapiens_hsa006703.50369199
6RNA transport_Homo sapiens_hsa030133.24382196
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.11300161
8Proteasome_Homo sapiens_hsa030503.04145809
9Ribosome_Homo sapiens_hsa030103.00009783
10Basal cell carcinoma_Homo sapiens_hsa052172.90518267
11RNA polymerase_Homo sapiens_hsa030202.84079190
12Hedgehog signaling pathway_Homo sapiens_hsa043402.56077268
13Cell cycle_Homo sapiens_hsa041102.46161671
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.40769311
15Base excision repair_Homo sapiens_hsa034102.23864812
16Nucleotide excision repair_Homo sapiens_hsa034202.18583214
17Primary immunodeficiency_Homo sapiens_hsa053402.07220909
18Asthma_Homo sapiens_hsa053102.05168385
19Homologous recombination_Homo sapiens_hsa034402.00314823
20mRNA surveillance pathway_Homo sapiens_hsa030151.98402868
21Allograft rejection_Homo sapiens_hsa053301.97751974
22Hippo signaling pathway_Homo sapiens_hsa043901.97162210
23Pyrimidine metabolism_Homo sapiens_hsa002401.89135338
24Non-homologous end-joining_Homo sapiens_hsa034501.82055562
25Autoimmune thyroid disease_Homo sapiens_hsa053201.81860702
26B cell receptor signaling pathway_Homo sapiens_hsa046621.69499867
27Biosynthesis of amino acids_Homo sapiens_hsa012301.67240017
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61754377
29RNA degradation_Homo sapiens_hsa030181.59608736
30Graft-versus-host disease_Homo sapiens_hsa053321.56846886
31p53 signaling pathway_Homo sapiens_hsa041151.56635369
32Type I diabetes mellitus_Homo sapiens_hsa049401.53919837
33TGF-beta signaling pathway_Homo sapiens_hsa043501.30914163
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.26701069
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25653961
36Fanconi anemia pathway_Homo sapiens_hsa034601.24201589
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24086745
38Selenocompound metabolism_Homo sapiens_hsa004501.17661158
39Wnt signaling pathway_Homo sapiens_hsa043101.15203824
40Thyroid cancer_Homo sapiens_hsa052161.12100170
41Oocyte meiosis_Homo sapiens_hsa041141.11123788
42Melanoma_Homo sapiens_hsa052181.10862946
43Adherens junction_Homo sapiens_hsa045201.10542713
44Basal transcription factors_Homo sapiens_hsa030221.05956437
45MicroRNAs in cancer_Homo sapiens_hsa052061.02748429
46Melanogenesis_Homo sapiens_hsa049160.99070754
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95621210
48Tight junction_Homo sapiens_hsa045300.95217675
49Purine metabolism_Homo sapiens_hsa002300.94058381
50Carbon metabolism_Homo sapiens_hsa012000.93217679
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90227246
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90121394
53Phenylalanine metabolism_Homo sapiens_hsa003600.90027566
54HTLV-I infection_Homo sapiens_hsa051660.89649969
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.85323424
56Epstein-Barr virus infection_Homo sapiens_hsa051690.85126869
57Systemic lupus erythematosus_Homo sapiens_hsa053220.82793024
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82328295
59Protein export_Homo sapiens_hsa030600.81937979
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79321444
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76912223
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.76499245
63Notch signaling pathway_Homo sapiens_hsa043300.75993710
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75951576
65Pathways in cancer_Homo sapiens_hsa052000.74512340
66Bladder cancer_Homo sapiens_hsa052190.72496455
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.71867542
68Influenza A_Homo sapiens_hsa051640.71536347
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70564758
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68054960
71Proteoglycans in cancer_Homo sapiens_hsa052050.67827952
72Viral carcinogenesis_Homo sapiens_hsa052030.67466057
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67011580
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.62487990
75Vitamin B6 metabolism_Homo sapiens_hsa007500.59155044
76N-Glycan biosynthesis_Homo sapiens_hsa005100.57911322
77Pyruvate metabolism_Homo sapiens_hsa006200.57300331
78Steroid biosynthesis_Homo sapiens_hsa001000.55048032
79Hepatitis B_Homo sapiens_hsa051610.53396642
80Leishmaniasis_Homo sapiens_hsa051400.49561051
81Pentose phosphate pathway_Homo sapiens_hsa000300.47313184
82Tyrosine metabolism_Homo sapiens_hsa003500.47138849
83Colorectal cancer_Homo sapiens_hsa052100.45454885
84Toxoplasmosis_Homo sapiens_hsa051450.45325756
85Antigen processing and presentation_Homo sapiens_hsa046120.44242903
86Rap1 signaling pathway_Homo sapiens_hsa040150.42728334
87Measles_Homo sapiens_hsa051620.42718726
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42617115
89Legionellosis_Homo sapiens_hsa051340.41404610
90Viral myocarditis_Homo sapiens_hsa054160.41134417
91Small cell lung cancer_Homo sapiens_hsa052220.37904471
92Prostate cancer_Homo sapiens_hsa052150.36985046
93Fructose and mannose metabolism_Homo sapiens_hsa000510.36853699
94Folate biosynthesis_Homo sapiens_hsa007900.35134746
95Lysine degradation_Homo sapiens_hsa003100.34850356
96mTOR signaling pathway_Homo sapiens_hsa041500.30900811
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30768459
98HIF-1 signaling pathway_Homo sapiens_hsa040660.30576940
99Herpes simplex infection_Homo sapiens_hsa051680.29627056
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29348484
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27266387
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26616533
103Endometrial cancer_Homo sapiens_hsa052130.26166757
104Alcoholism_Homo sapiens_hsa050340.25710231
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25641846
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25512819
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25217973
108Glutathione metabolism_Homo sapiens_hsa004800.24334898
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23715607
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22236905
111Propanoate metabolism_Homo sapiens_hsa006400.21580619
112Chronic myeloid leukemia_Homo sapiens_hsa052200.19857140
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18758174
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16954064
115Huntingtons disease_Homo sapiens_hsa050160.16941654
116Sulfur relay system_Homo sapiens_hsa041220.15592282
117Retinol metabolism_Homo sapiens_hsa008300.15300203
118Arginine and proline metabolism_Homo sapiens_hsa003300.14387963
119Galactose metabolism_Homo sapiens_hsa000520.13807862
120Glucagon signaling pathway_Homo sapiens_hsa049220.13476816
121Fat digestion and absorption_Homo sapiens_hsa049750.12626559
122Shigellosis_Homo sapiens_hsa051310.12096910
123Axon guidance_Homo sapiens_hsa043600.12025367
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.11631742
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10597080
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09848611
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06993839
128Apoptosis_Homo sapiens_hsa042100.06617625
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06537722

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