TAB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycoprotein catabolic process (GO:0006516)9.47387980
2rRNA transcription (GO:0009303)8.83077130
3positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)7.86889621
4renal absorption (GO:0070293)6.89802826
5positive regulation of signal transduction by p53 class mediator (GO:1901798)6.65321082
6macroautophagy (GO:0016236)6.39641427
7SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)6.06867265
8induction of positive chemotaxis (GO:0050930)6.02969100
9UV protection (GO:0009650)5.81798401
10positive regulation of vascular permeability (GO:0043117)5.70366980
11erythrocyte maturation (GO:0043249)5.52752968
12regulation of translational fidelity (GO:0006450)5.41989917
13ribosomal small subunit assembly (GO:0000028)5.01554242
14histone H4 deacetylation (GO:0070933)4.90674298
15astrocyte differentiation (GO:0048708)4.61102541
16hematopoietic stem cell differentiation (GO:0060218)4.58475103
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.40232770
18ethanol oxidation (GO:0006069)4.28616114
19regulation of skeletal muscle contraction (GO:0014819)4.12029857
20primary alcohol catabolic process (GO:0034310)4.02256545
21myelin assembly (GO:0032288)3.99787601
22maintenance of protein location in nucleus (GO:0051457)3.88720880
23pentose-phosphate shunt (GO:0006098)3.88243418
24viral transcription (GO:0019083)3.85274001
25hair cell differentiation (GO:0035315)3.83178029
26histone H3 deacetylation (GO:0070932)3.81698377
27Golgi transport vesicle coating (GO:0048200)3.80249724
28COPI coating of Golgi vesicle (GO:0048205)3.80249724
29DNA unwinding involved in DNA replication (GO:0006268)3.78428364
30one-carbon compound transport (GO:0019755)3.74316665
31positive regulation of monocyte chemotaxis (GO:0090026)3.71916608
32vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.71769551
33regulation of synapse maturation (GO:0090128)3.63395561
34endocardial cushion morphogenesis (GO:0003203)3.62650276
35protein localization to kinetochore (GO:0034501)3.59347349
36translational termination (GO:0006415)3.58357150
37spinal cord development (GO:0021510)3.58086195
38mesenchyme morphogenesis (GO:0072132)3.54996437
39regulation of type B pancreatic cell apoptotic process (GO:2000674)3.51118111
40meiotic chromosome segregation (GO:0045132)3.50252224
41translational elongation (GO:0006414)3.47122128
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.44367567
43regulation of cardioblast proliferation (GO:0003264)3.39540993
44regulation of secondary heart field cardioblast proliferation (GO:0003266)3.39540993
45energy homeostasis (GO:0097009)3.39359017
46negative regulation of erythrocyte differentiation (GO:0045647)3.37679236
47outer ear morphogenesis (GO:0042473)3.36301770
48cell-cell junction maintenance (GO:0045217)3.36287323
49cytoplasmic sequestering of transcription factor (GO:0042994)3.34560618
50peptidyl-arginine omega-N-methylation (GO:0035247)3.31169531
51DNA strand elongation involved in DNA replication (GO:0006271)3.30884748
52NADPH regeneration (GO:0006740)3.29442428
53positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.29116325
54astrocyte development (GO:0014002)3.28286483
55response to pheromone (GO:0019236)3.25439046
56establishment of viral latency (GO:0019043)3.25147396
57positive regulation of defense response to virus by host (GO:0002230)3.24345503
58embryonic foregut morphogenesis (GO:0048617)3.21789420
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.21089574
60lateral ventricle development (GO:0021670)3.20726535
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20702028
62cardiac myofibril assembly (GO:0055003)3.18867208
63nuclear envelope reassembly (GO:0031468)3.18660643
64mitotic nuclear envelope reassembly (GO:0007084)3.18660643
65forebrain morphogenesis (GO:0048853)3.18087038
66regulation of lymphocyte migration (GO:2000401)3.17672861
67formation of translation preinitiation complex (GO:0001731)3.17607799
68regulation of ARF protein signal transduction (GO:0032012)3.17223544
69regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.16105402
70sarcomere organization (GO:0045214)3.15506545
71plasma membrane repair (GO:0001778)3.15210100
72maturation of SSU-rRNA (GO:0030490)3.14448960
73synaptonemal complex assembly (GO:0007130)3.14063652
74glucose catabolic process (GO:0006007)3.11761115
75DNA strand elongation (GO:0022616)3.10844680
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09815513
77barbed-end actin filament capping (GO:0051016)3.04137955
78regulation of translation in response to stress (GO:0043555)3.02687361
79positive regulation of interleukin-8 secretion (GO:2000484)3.01614033
80chondroitin sulfate catabolic process (GO:0030207)3.01423209
81negative regulation of RNA splicing (GO:0033119)3.01229226
82protein targeting to ER (GO:0045047)2.99262679
83telomere maintenance via semi-conservative replication (GO:0032201)2.98858781
84IMP biosynthetic process (GO:0006188)2.97272995
85cotranslational protein targeting to membrane (GO:0006613)2.97237568
86embryonic skeletal joint morphogenesis (GO:0060272)2.95741604
87heart valve formation (GO:0003188)2.95080239
88cellular protein complex disassembly (GO:0043624)2.94850641
89ethanol metabolic process (GO:0006067)2.94780134
90protein targeting to vacuole (GO:0006623)2.92786563
91protein targeting to lysosome (GO:0006622)2.92786563
92establishment of protein localization to vacuole (GO:0072666)2.92786563
93positive regulation of gamma-delta T cell activation (GO:0046645)2.92232203
94regulation of monocyte chemotaxis (GO:0090025)2.91622115
95maintenance of protein localization in organelle (GO:0072595)2.91541588
96regulation of chromatin binding (GO:0035561)2.89109185
97protein complex disassembly (GO:0043241)2.88353100
98diacylglycerol metabolic process (GO:0046339)2.86965946
99mitotic recombination (GO:0006312)2.86503495
100regulation of DNA damage checkpoint (GO:2000001)2.86412717
101negative regulation of telomere maintenance (GO:0032205)2.86411926
102establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86193150
103viral life cycle (GO:0019058)2.85759819
104positive regulation of histone deacetylation (GO:0031065)2.85173890
105histone H4-K12 acetylation (GO:0043983)2.84984323
106regulation of monocyte differentiation (GO:0045655)2.84820132
107ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.84690076
108cytoplasmic sequestering of protein (GO:0051220)2.83751429
109translational initiation (GO:0006413)2.83481353
110leukocyte cell-cell adhesion (GO:0007159)2.83426600
111regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.83372519
112negative regulation of focal adhesion assembly (GO:0051895)2.82295198
113negative regulation of cell junction assembly (GO:1901889)2.82295198
114negative regulation of adherens junction organization (GO:1903392)2.82295198
115cardiovascular system development (GO:0072358)2.81923903
116positive regulation of positive chemotaxis (GO:0050927)2.80225639
117negative regulation of mRNA processing (GO:0050686)2.76972984
118homotypic cell-cell adhesion (GO:0034109)2.76091008
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.75852511
120anatomical structure maturation (GO:0071695)2.75675509
121IMP metabolic process (GO:0046040)2.75436463
122intracellular estrogen receptor signaling pathway (GO:0030520)2.74402469
123oxidative phosphorylation (GO:0006119)2.74012366
124nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73926456
125protein retention in ER lumen (GO:0006621)2.73868425
126negative regulation of phagocytosis (GO:0050765)2.73835887
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73722177
128protein localization to endoplasmic reticulum (GO:0070972)2.72911707
129cellular response to pH (GO:0071467)2.72310403
130histone deacetylation (GO:0016575)2.71719325
131hyaluronan catabolic process (GO:0030214)2.69575956
132de novo posttranslational protein folding (GO:0051084)2.68865145
133xenobiotic catabolic process (GO:0042178)2.68825001
134generation of neurons (GO:0048699)2.68258246
135peroxisome organization (GO:0007031)2.67608092
136macromolecular complex disassembly (GO:0032984)2.67466683
137regulation of early endosome to late endosome transport (GO:2000641)2.66388668
138protoporphyrinogen IX biosynthetic process (GO:0006782)2.66085043
139beta-amyloid metabolic process (GO:0050435)2.64657569
140protoporphyrinogen IX metabolic process (GO:0046501)2.64281663
141antibacterial humoral response (GO:0019731)2.63858658
142regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63615653
143deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62176659
144protein-DNA complex disassembly (GO:0032986)2.59971952
145nucleosome disassembly (GO:0006337)2.59971952
146tricarboxylic acid cycle (GO:0006099)2.57016510
147regulation of positive chemotaxis (GO:0050926)2.56830100
148negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.56329310
149response to nitrosative stress (GO:0051409)2.55272815
150nucleobase biosynthetic process (GO:0046112)2.54908407
151regulation of translational elongation (GO:0006448)2.53146591
152macrophage activation involved in immune response (GO:0002281)2.51132291
153regulation of natural killer cell mediated immunity (GO:0002715)2.51045947
154regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51045947
155apoptotic process involved in morphogenesis (GO:0060561)2.50840973
156iron-sulfur cluster assembly (GO:0016226)2.49391282
157metallo-sulfur cluster assembly (GO:0031163)2.49391282
158response to UV-B (GO:0010224)2.48857369
159metanephric mesenchyme development (GO:0072075)2.48275580
160neuron projection extension involved in neuron projection guidance (GO:1902284)2.48078076
161axon extension involved in axon guidance (GO:0048846)2.48078076
162regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.47314171
163membrane invagination (GO:0010324)2.45583414
164synaptonemal complex organization (GO:0070193)2.45314309
165regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44757984
166retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44568302
167peptidyl-arginine N-methylation (GO:0035246)2.44206416
168peptidyl-arginine methylation (GO:0018216)2.44206416
169cardiac muscle contraction (GO:0060048)2.43403846
1703-UTR-mediated mRNA stabilization (GO:0070935)2.42816503
171negative regulation of epidermis development (GO:0045683)2.42697873
172lymphocyte chemotaxis (GO:0048247)2.42023970
173peroxisome fission (GO:0016559)2.41540450
174antimicrobial humoral response (GO:0019730)2.41011129
175de novo protein folding (GO:0006458)2.40711221
176nephron tubule formation (GO:0072079)2.40453221
177regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.40167803
178epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39034105
179protein localization to chromosome, centromeric region (GO:0071459)2.37990995
180nonmotile primary cilium assembly (GO:0035058)2.37787212
181carnitine metabolic process (GO:0009437)2.37758992
182cell junction maintenance (GO:0034331)2.36849538
183negative regulation of granulocyte differentiation (GO:0030853)2.36624757
184cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.36559435
185ribosomal small subunit biogenesis (GO:0042274)2.36049301
186maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35465570
187negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34600515
188ventricular cardiac muscle cell action potential (GO:0086005)2.34372356
189atrioventricular valve morphogenesis (GO:0003181)2.34021545
190pentose metabolic process (GO:0019321)2.33004076
191antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32031029
192negative regulation of cell killing (GO:0031342)2.31944647
193negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.31944647
194positive regulation of natural killer cell mediated immunity (GO:0002717)2.31785337
195leukocyte aggregation (GO:0070486)12.7597419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.91695770
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.40878110
3MYC_22102868_ChIP-Seq_BL_Human3.71514367
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.19966683
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74570834
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.72204288
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67972063
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.63809483
9VDR_21846776_ChIP-Seq_THP-1_Human2.47183279
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.22138200
11* XRN2_22483619_ChIP-Seq_HELA_Human2.21224716
12CIITA_25753668_ChIP-Seq_RAJI_Human2.04738914
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02865048
14ELF1_20517297_ChIP-Seq_JURKAT_Human2.01894943
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00852021
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99291002
17CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.98675936
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96387792
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86777837
20SCL_19346495_ChIP-Seq_HPC-7_Human1.86659385
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83351150
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77293985
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76373781
24KDM2B_26808549_Chip-Seq_JURKAT_Human1.75205127
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74957073
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73987873
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71624638
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.70444454
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.70090524
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68507808
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67554730
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66572268
33SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.65901612
34KDM2B_26808549_Chip-Seq_DND41_Human1.65407271
35SMC4_20622854_ChIP-Seq_HELA_Human1.61426891
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60992755
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60103693
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59772840
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56783957
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55677519
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53936859
42UTX_26944678_Chip-Seq_JUKART_Human1.51661317
43* TCF7_22412390_ChIP-Seq_EML_Mouse1.50546042
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49978811
45LXR_22292898_ChIP-Seq_THP-1_Human1.48302271
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48161206
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46682365
48KDM2B_26808549_Chip-Seq_K562_Human1.45049598
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.44825656
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42689531
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39347790
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38775522
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38647652
54ZNF263_19887448_ChIP-Seq_K562_Human1.38601224
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37999405
56AR_21909140_ChIP-Seq_LNCAP_Human1.37955092
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37672038
58E2F1_20622854_ChIP-Seq_HELA_Human1.36118833
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35792815
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35371801
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34742353
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.34326626
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.34124614
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33313802
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33241575
66DROSHA_22980978_ChIP-Seq_HELA_Human1.33185179
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33166871
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31932352
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31693680
70* ETS1_21867929_ChIP-Seq_TH2_Mouse1.30790251
71CTCF_27219007_Chip-Seq_Bcells_Human1.29053399
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.27841267
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27619936
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27367308
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27020703
76CREB1_26743006_Chip-Seq_LNCaP_Human1.26748871
77SA1_27219007_Chip-Seq_Bcells_Human1.26306673
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25684086
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25370934
80VDR_24763502_ChIP-Seq_THP-1_Human1.25127818
81CLOCK_20551151_ChIP-Seq_293T_Human1.24738276
82* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23078081
83STAT1_20625510_ChIP-Seq_HELA_Human1.22669023
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22444081
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22157881
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21749392
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21256276
88* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20900030
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20638052
90CTCF_21964334_Chip-Seq_Bcells_Human1.19944477
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19576526
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19087578
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18880525
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18603112
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17653352
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.17605144
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17463081
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16870905
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16532752
100BCOR_27268052_Chip-Seq_Bcells_Human1.15457991
101JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14962517
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14672626
103BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13717797
104* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13639585
105P68_20966046_ChIP-Seq_HELA_Human1.12969171
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12956848
107MAF_26560356_Chip-Seq_TH1_Human1.12513874
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12312925
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.12307018
110GABP_19822575_ChIP-Seq_HepG2_Human1.11249235
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10284657
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.08974406
113* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08619849
114* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08419096
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.08184420
116GABP_17652178_ChIP-ChIP_JURKAT_Human1.08128961
117OCT4_19829295_ChIP-Seq_ESCs_Human1.07418359
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07263397
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07144630
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07098211
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06935241
122RACK7_27058665_Chip-Seq_MCF-7_Human1.05636801
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05557676
124CTCF_26484167_Chip-Seq_Bcells_Mouse1.05479234
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05451118
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04265886
127NCOR1_26117541_ChIP-Seq_K562_Human1.03229654
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03080824
129TTF2_22483619_ChIP-Seq_HELA_Human1.02318321
130RUNX1_22412390_ChIP-Seq_EML_Mouse1.02169355
131FOXP3_21729870_ChIP-Seq_TREG_Human1.02078245
132PHF8_20622854_ChIP-Seq_HELA_Human1.00966021
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00929483
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99895539
135TP53_22127205_ChIP-Seq_IMR90_Human0.99849197
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99379316
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.99232286
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.99046898
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98922566
140SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98784880
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98620964
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.98503077
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97962203
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97785485
145BCL6_27268052_Chip-Seq_Bcells_Human0.97498604
146SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97107568
147SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95072987
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94429699
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93481216
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92669585
151DCP1A_22483619_ChIP-Seq_HELA_Human0.92288427
152EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92198382
153MAF_26560356_Chip-Seq_TH2_Human0.91745265
154NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91514916
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91252905
156VDR_23849224_ChIP-Seq_CD4+_Human0.91163447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium5.40186928
2MP0000750_abnormal_muscle_regeneration5.20344067
3MP0010030_abnormal_orbit_morphology4.26946190
4MP0005394_taste/olfaction_phenotype4.18946019
5MP0005499_abnormal_olfactory_system4.18946019
6MP0004043_abnormal_pH_regulation4.10906641
7MP0009384_cardiac_valve_regurgitation4.05511688
8MP0004147_increased_porphyrin_level3.44270556
9MP0000858_altered_metastatic_potential3.40943546
10MP0004947_skin_inflammation2.70517364
11MP0008260_abnormal_autophagy2.61907738
12MP0008007_abnormal_cellular_replicative2.52624216
13MP0002837_dystrophic_cardiac_calcinosis2.44605890
14MP0006054_spinal_hemorrhage2.15851982
15MP0000003_abnormal_adipose_tissue2.13041740
16MP0010368_abnormal_lymphatic_system2.02115994
17MP0002249_abnormal_larynx_morphology2.00816715
18MP0000049_abnormal_middle_ear2.00702198
19MP0005623_abnormal_meninges_morphology11.6469808
20MP0004084_abnormal_cardiac_muscle1.98230224
21MP0000751_myopathy1.95743704
22MP0002269_muscular_atrophy1.95451904
23MP0004808_abnormal_hematopoietic_stem1.78970385
24MP0000678_abnormal_parathyroid_gland1.76500201
25MP0002234_abnormal_pharynx_morphology1.71481452
26MP0002877_abnormal_melanocyte_morpholog1.70966719
27MP0010307_abnormal_tumor_latency1.65003774
28MP0003300_gastrointestinal_ulcer1.64161452
29MP0002396_abnormal_hematopoietic_system1.60839150
30MP0003111_abnormal_nucleus_morphology1.59421500
31MP0003279_aneurysm1.59359336
32MP0002653_abnormal_ependyma_morphology1.57948475
33MP0005058_abnormal_lysosome_morphology1.51467033
34MP0005451_abnormal_body_composition1.51330356
35MP0000490_abnormal_crypts_of1.47454924
36MP0002233_abnormal_nose_morphology1.47422110
37MP0004859_abnormal_synaptic_plasticity1.46708247
38MP0002132_abnormal_respiratory_system1.46465302
39MP0004858_abnormal_nervous_system1.46379651
40MP0001849_ear_inflammation1.44864777
41MP0003221_abnormal_cardiomyocyte_apopto1.43402014
42MP0004130_abnormal_muscle_cell1.42043493
43MP0005584_abnormal_enzyme/coenzyme_acti1.39580300
44MP0009379_abnormal_foot_pigmentation1.38631575
45MP0003329_amyloid_beta_deposits1.38438332
46MP0005671_abnormal_response_to1.36648827
47* MP0010630_abnormal_cardiac_muscle1.32662824
48MP0003941_abnormal_skin_development1.31989230
49MP0003123_paternal_imprinting1.30459078
50MP0000537_abnormal_urethra_morphology1.29876798
51MP0003828_pulmonary_edema1.28616793
52MP0002938_white_spotting1.27304809
53MP0003077_abnormal_cell_cycle1.25332439
54MP0010094_abnormal_chromosome_stability1.24580129
55MP0000749_muscle_degeneration1.23531279
56MP0005375_adipose_tissue_phenotype1.21360593
57MP0002751_abnormal_autonomic_nervous1.18666003
58MP0003566_abnormal_cell_adhesion1.15716553
59MP0000759_abnormal_skeletal_muscle1.13899915
60MP0000467_abnormal_esophagus_morphology1.13406326
61MP0004215_abnormal_myocardial_fiber1.13322660
62MP0003763_abnormal_thymus_physiology1.11014952
63MP0003693_abnormal_embryo_hatching1.10382790
64MP0003436_decreased_susceptibility_to1.10113602
65MP0003690_abnormal_glial_cell1.10097746
66MP0000762_abnormal_tongue_morphology1.05098480
67MP0002638_abnormal_pupillary_reflex1.03652514
68MP0002098_abnormal_vibrissa_morphology1.03530088
69* MP0004087_abnormal_muscle_fiber1.03508815
70MP0001545_abnormal_hematopoietic_system1.01276139
71MP0005397_hematopoietic_system_phenotyp1.01276139
72MP0001270_distended_abdomen1.00806249
73MP0003656_abnormal_erythrocyte_physiolo0.99223231
74MP0003786_premature_aging0.98571460
75MP0005023_abnormal_wound_healing0.98557438
76MP0000465_gastrointestinal_hemorrhage0.96953679
77MP0003453_abnormal_keratinocyte_physiol0.96749153
78MP0008874_decreased_physiological_sensi0.96720453
79MP0001984_abnormal_olfaction0.96711951
80MP0002932_abnormal_joint_morphology0.95674117
81MP0005076_abnormal_cell_differentiation0.93347604
82MP0000013_abnormal_adipose_tissue0.93217289
83MP0000343_altered_response_to0.92983044
84MP0008775_abnormal_heart_ventricle0.91567554
85MP0003879_abnormal_hair_cell0.91244479
86MP0008995_early_reproductive_senescence0.90545148
87MP0004185_abnormal_adipocyte_glucose0.89394252
88MP0000733_abnormal_muscle_development0.89148641
89MP0003303_peritoneal_inflammation0.87621764
90MP0002089_abnormal_postnatal_growth/wei0.87069488
91MP0002933_joint_inflammation0.85928901
92MP0008770_decreased_survivor_rate0.84187552
93MP0003122_maternal_imprinting0.82847411
94MP0002127_abnormal_cardiovascular_syste0.81654683
95MP0000534_abnormal_ureter_morphology0.81417009
96MP0008961_abnormal_basal_metabolism0.81318381
97MP0005025_abnormal_response_to0.80713128
98* MP0002080_prenatal_lethality0.80298430
99MP0000428_abnormal_craniofacial_morphol0.80008462
100MP0003385_abnormal_body_wall0.79244464
101MP0001544_abnormal_cardiovascular_syste0.79223294
102MP0005385_cardiovascular_system_phenoty0.79223294
103MP0009333_abnormal_splenocyte_physiolog0.79137084
104MP0000350_abnormal_cell_proliferation0.78371362
105MP0002177_abnormal_outer_ear0.78218553
106MP0002822_catalepsy0.77906113
107MP0001958_emphysema0.77789500
108MP0002106_abnormal_muscle_physiology0.76337464
109MP0009278_abnormal_bone_marrow0.75504442
110MP0003942_abnormal_urinary_system0.75185257
111MP0003705_abnormal_hypodermis_morpholog0.73299330
112MP0004085_abnormal_heartbeat0.72694700
113MP0010352_gastrointestinal_tract_polyps0.71743473
114MP0003137_abnormal_impulse_conducting0.71642879
115MP0005464_abnormal_platelet_physiology0.71624197
116MP0005083_abnormal_biliary_tract0.71289110
117MP0000703_abnormal_thymus_morphology0.71217035
118MP0004233_abnormal_muscle_weight0.71195288
119MP0004036_abnormal_muscle_relaxation0.69680920
120MP0009840_abnormal_foam_cell0.69577821
121MP0008569_lethality_at_weaning0.69506059
122MP0002085_abnormal_embryonic_tissue0.69505160
123MP0002067_abnormal_sensory_capabilities0.68213417
124MP0002419_abnormal_innate_immunity0.68211248
125MP0001502_abnormal_circadian_rhythm0.68047705
126MP0005408_hypopigmentation0.67072823
127MP0002111_abnormal_tail_morphology0.66682803
128MP0006292_abnormal_olfactory_placode0.66157002
129MP0001915_intracranial_hemorrhage0.65279276
130MP0002019_abnormal_tumor_incidence0.65009389
131MP0001730_embryonic_growth_arrest0.64914658
132MP0003938_abnormal_ear_development0.64868779
133MP0005501_abnormal_skin_physiology0.64766600
134MP0004957_abnormal_blastocyst_morpholog0.64675711
135MP0003172_abnormal_lysosome_physiology0.64552062
136MP0003935_abnormal_craniofacial_develop0.64105912
137MP0002972_abnormal_cardiac_muscle0.63785832
138MP0001348_abnormal_lacrimal_gland0.63034020
139MP0006138_congestive_heart_failure0.63013065
140MP0001873_stomach_inflammation0.62985748
141MP0004197_abnormal_fetal_growth/weight/0.62832020
142* MP0000266_abnormal_heart_morphology0.62727022
143MP0005369_muscle_phenotype0.62061317
144MP0005330_cardiomyopathy0.60963438
145MP0002925_abnormal_cardiovascular_devel0.60803749
146MP0004264_abnormal_extraembryonic_tissu0.60551171
147MP0002420_abnormal_adaptive_immunity0.60067950
148MP0001346_abnormal_lacrimal_gland0.59958823
149MP0000566_synostosis0.58394531
150MP0001819_abnormal_immune_cell0.57954775
151MP0002116_abnormal_craniofacial_bone0.57594518
152MP0003699_abnormal_female_reproductive0.53877210
153MP0002152_abnormal_brain_morphology0.53190196
154MP0009765_abnormal_xenobiotic_induced0.53189560
155MP0001800_abnormal_humoral_immune0.53167008
156MP0005508_abnormal_skeleton_morphology0.52046575
157MP0000681_abnormal_thyroid_gland0.52033849
158* MP0005621_abnormal_cell_physiology0.50481656
159MP0005193_abnormal_anterior_eye0.48422581
160MP0003755_abnormal_palate_morphology0.48117872
161MP0003634_abnormal_glial_cell0.46896542
162MP0003191_abnormal_cellular_cholesterol0.46260341
163MP0003448_altered_tumor_morphology0.45484553
164MP0002722_abnormal_immune_system0.45296843
165MP0002723_abnormal_immune_serum0.44721499
166MP0000747_muscle_weakness0.44136904
167MP0003861_abnormal_nervous_system0.43883460
168MP0003866_abnormal_defecation0.43870961
169MP0001299_abnormal_eye_distance/0.43565624

Predicted human phenotypes

RankGene SetZ-score
1Fatigue (HP:0012378)9.04439049
2Type II lissencephaly (HP:0007260)8.57630871
3Retinal dysplasia (HP:0007973)8.22411383
4Difficulty climbing stairs (HP:0003551)8.18589481
5Hypoplasia of the pons (HP:0012110)7.70170636
6Buphthalmos (HP:0000557)7.10747242
7Abnormality of the pons (HP:0007361)6.75207450
8Aplasia/Hypoplasia affecting the retina (HP:0008061)5.98602715
9Decreased electroretinogram (ERG) amplitude (HP:0000654)5.79173135
10Large eyes (HP:0001090)5.52030797
11Congenital glaucoma (HP:0001087)4.73556281
12Megalocornea (HP:0000485)4.46666023
13Hyperacusis (HP:0010780)4.20099477
14Entropion (HP:0000621)4.02713868
15Morphological abnormality of the middle ear (HP:0008609)3.90194328
16Supranuclear gaze palsy (HP:0000605)3.85649939
17Severe muscular hypotonia (HP:0006829)3.65583817
18Abolished electroretinogram (ERG) (HP:0000550)3.60617018
19Broad face (HP:0000283)3.28594499
20Poikiloderma (HP:0001029)3.27881008
21Abnormality of vision evoked potentials (HP:0000649)3.20607943
22Ventricular tachycardia (HP:0004756)3.09272791
23Prominent metopic ridge (HP:0005487)3.06741983
24Spinal cord lesions (HP:0100561)3.06055152
25Syringomyelia (HP:0003396)3.06055152
26Down-sloping shoulders (HP:0200021)3.04079064
27Asymmetry of the thorax (HP:0001555)3.03355513
28Generalized muscle weakness (HP:0003324)3.02007235
29Gowers sign (HP:0003391)2.94814986
30Hyperactive renin-angiotensin system (HP:0000841)2.93171989
31Aplasia/Hypoplasia of the brainstem (HP:0007362)2.92966514
32Hypoplasia of the brainstem (HP:0002365)2.92966514
33Slow saccadic eye movements (HP:0000514)2.91240331
34Selective tooth agenesis (HP:0001592)2.91110160
35Severe global developmental delay (HP:0011344)2.89762601
36Abnormal number of incisors (HP:0011064)2.88587878
37Muscle stiffness (HP:0003552)2.87089881
38Abnormal number of erythroid precursors (HP:0012131)2.86681989
39Abnormality of the metopic suture (HP:0005556)2.83851503
40Meningocele (HP:0002435)2.83621407
41Right ventricular cardiomyopathy (HP:0011663)2.81564781
42Intellectual disability, profound (HP:0002187)2.77404136
43Insomnia (HP:0100785)2.73782633
44Bilateral microphthalmos (HP:0007633)2.71849106
45Abnormality of cells of the erythroid lineage (HP:0012130)2.66157249
46Abnormality of DNA repair (HP:0003254)2.63137183
47Papilledema (HP:0001085)2.62042848
48Increased IgM level (HP:0003496)2.60391311
49Lipoatrophy (HP:0100578)2.58808446
50Fragile nails (HP:0001808)2.54508589
51Abnormality of the heme biosynthetic pathway (HP:0010472)2.53728528
52Slender long bone (HP:0003100)2.49505238
53Lissencephaly (HP:0001339)2.49456004
54Failure to thrive in infancy (HP:0001531)2.45036068
55Gait imbalance (HP:0002141)2.41589484
56Increased circulating renin level (HP:0000848)2.40891467
57Bronchomalacia (HP:0002780)2.40358257
58Protrusio acetabuli (HP:0003179)2.39458022
59Pointed chin (HP:0000307)2.39064725
60Abnormality of the vitreous humor (HP:0004327)2.38647314
61Muscular dystrophy (HP:0003560)2.37927475
62Congenital primary aphakia (HP:0007707)2.36191064
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.36166794
64Rectal prolapse (HP:0002035)2.34038326
65Cutaneous melanoma (HP:0012056)2.30213065
66Sudden death (HP:0001699)2.28886100
67Preauricular skin tag (HP:0000384)2.27211378
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.23784610
69Decreased subcutaneous fat (HP:0001002)2.23317548
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.23011564
71Abnormality of the aortic arch (HP:0012303)2.22642580
72Hypercalciuria (HP:0002150)2.20948538
73Thrombocytosis (HP:0001894)2.16942623
74Long palpebral fissure (HP:0000637)2.16846413
75Pachygyria (HP:0001302)2.15057049
76Fragile skin (HP:0001030)2.12609982
77Ankle contracture (HP:0006466)2.11300256
78Posterior subcapsular cataract (HP:0007787)2.09809938
79Short 4th metacarpal (HP:0010044)2.09623983
80Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09623983
81Bicuspid aortic valve (HP:0001647)2.08677706
82Non-midline cleft lip (HP:0100335)2.08597845
83Pallor (HP:0000980)2.04677524
84Hypokalemic alkalosis (HP:0001949)2.04077622
85Scapular winging (HP:0003691)2.02195735
86Renal duplication (HP:0000075)2.02074746
87Adducted thumb (HP:0001181)2.00515911
88Retinal atrophy (HP:0001105)11.1323260
89Cerebellar dysplasia (HP:0007033)10.2492154
90Limb-girdle muscle atrophy (HP:0003797)1.99940842
91Skin tags (HP:0010609)1.98923635
92Nephrogenic diabetes insipidus (HP:0009806)1.98688819
93Abnormality of oral frenula (HP:0000190)1.97751193
94Increased connective tissue (HP:0009025)1.97184436
95Pterygium (HP:0001059)1.95046899
96Elfin facies (HP:0004428)1.95029420
97Midface retrusion (HP:0011800)1.94239224
98Increased density of long bones (HP:0006392)1.94089892
99Palpitations (HP:0001962)1.93940694
100Death in childhood (HP:0003819)1.92347173
101Mesangial abnormality (HP:0001966)1.90188616
102Subaortic stenosis (HP:0001682)1.89634392
103Abnormality of the left ventricular outflow tract (HP:0011103)1.89634392
104Bowel diverticulosis (HP:0005222)1.89475167
105Lip pit (HP:0100267)1.88087997
106IgG deficiency (HP:0004315)1.87512727
107Subacute progressive viral hepatitis (HP:0006572)1.85363257
108Broad palm (HP:0001169)1.85122667
109Supraventricular tachycardia (HP:0004755)1.85044896
110Vaginal atresia (HP:0000148)1.84358759
111Dislocated radial head (HP:0003083)1.84207980
112Vertebral arch anomaly (HP:0008438)1.83531212
113Abnormality of subcutaneous fat tissue (HP:0001001)1.82909083
114Supraventricular arrhythmia (HP:0005115)1.82596679
115Abnormal platelet function (HP:0011869)1.80956457
116Impaired platelet aggregation (HP:0003540)1.80956457
117Exercise-induced muscle cramps (HP:0003710)1.80635258
118Myotonia (HP:0002486)1.80462346
119Trismus (HP:0000211)1.80334037
120Exercise-induced myalgia (HP:0003738)1.78178159
121Ventricular arrhythmia (HP:0004308)1.76657220
122Eczematoid dermatitis (HP:0000976)1.76608372
123Type 1 muscle fiber predominance (HP:0003803)1.75608342
124Renal salt wasting (HP:0000127)1.75083230
125Ankyloglossia (HP:0010296)1.74652250
126Dilated cardiomyopathy (HP:0001644)1.73587911
127Periodontitis (HP:0000704)1.72630176
128Abnormality of the radial head (HP:0003995)1.72500332
129Left ventricular hypertrophy (HP:0001712)1.72151455
130Overriding aorta (HP:0002623)1.71240337
131Polymicrogyria (HP:0002126)1.71210278
132IgM deficiency (HP:0002850)1.67767460
133Sacral dimple (HP:0000960)1.66681740
134Keratitis (HP:0000491)1.66352574
135Redundant skin (HP:0001582)1.64621122
136Shallow orbits (HP:0000586)1.64477637
137Abnormality of magnesium homeostasis (HP:0004921)1.64078501
138Abnormality of alanine metabolism (HP:0010916)1.63498929
139Hyperalaninemia (HP:0003348)1.63498929
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63498929
141Hemorrhage of the eye (HP:0011885)1.62873870
142Bell-shaped thorax (HP:0001591)1.62710032
143Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.62343107
144Abnormality of saccadic eye movements (HP:0000570)1.60245890
145Abnormality of fatty-acid metabolism (HP:0004359)1.60080079
146Germ cell neoplasia (HP:0100728)1.58647890
147Hyperaldosteronism (HP:0000859)1.58338615
148Generalized hypotonia (HP:0001290)1.58315807
149Omphalocele (HP:0001539)1.58185053
150Self-mutilation (HP:0000742)1.57970645
151Genital tract atresia (HP:0001827)1.57763302
152Disproportionate tall stature (HP:0001519)1.57610286
153Retinal detachment (HP:0000541)1.57268896
154Tetany (HP:0001281)1.57082871
155Cerebral hypomyelination (HP:0006808)1.56902010
156Abnormality of macrophages (HP:0004311)1.56801628
15711 pairs of ribs (HP:0000878)1.56664289
158Micronodular cirrhosis (HP:0001413)1.54274595
159Personality changes (HP:0000751)1.51650948
160Supernumerary ribs (HP:0005815)1.47536141
161Submucous cleft hard palate (HP:0000176)1.45800710
162Mucopolysacchariduria (HP:0008155)1.45563734
163Urinary glycosaminoglycan excretion (HP:0003541)1.45563734
164Brittle hair (HP:0002299)1.45464810
165Spontaneous hematomas (HP:0007420)1.45162697
166Ileus (HP:0002595)1.42937362
167Ankle clonus (HP:0011448)1.40284385
168Granulocytopenia (HP:0001913)1.39582078
169Breast hypoplasia (HP:0003187)1.39343545
170Cholelithiasis (HP:0001081)1.38931713
171Abnormality of incisor morphology (HP:0011063)1.38854140
172Neurofibrillary tangles (HP:0002185)1.37568751
173Reticulocytosis (HP:0001923)1.37512244
174Delayed closure of the anterior fontanelle (HP:0001476)1.37009875
175Hypergammaglobulinemia (HP:0010702)1.35581399
176Everted lower lip vermilion (HP:0000232)1.35524833
177Abnormality of polysaccharide metabolism (HP:0011012)1.34285803
178Abnormality of glycosaminoglycan metabolism (HP:0004371)1.34285803
179Abnormality of mucopolysaccharide metabolism (HP:0011020)1.34285803
180Cerebral inclusion bodies (HP:0100314)1.33138243
181Myoclonus (HP:0001336)1.29135328
182High anterior hairline (HP:0009890)1.27212477
183Eosinophilia (HP:0001880)1.26614535
184Cerebral aneurysm (HP:0004944)1.25343046
185Congenital ichthyosiform erythroderma (HP:0007431)1.24797067
186Elevated erythrocyte sedimentation rate (HP:0003565)1.22587104
187Hypertensive crisis (HP:0100735)1.21005097
188Intellectual disability, severe (HP:0010864)1.19840705
189Mitral regurgitation (HP:0001653)1.19388713
190Akinesia (HP:0002304)1.19092641
191Annular pancreas (HP:0001734)1.18597474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK37.05061542
2TRIB33.56046005
3EEF2K3.23844615
4TTN2.95835889
5MKNK12.81640599
6MAP3K102.69290434
7RPS6KB22.61130511
8PKN22.57717314
9STK112.49737719
10PIM12.46548285
11PASK2.45336155
12EPHB22.22582671
13PRPF4B2.14328946
14BLK2.13809937
15WNK32.11903764
16MKNK22.11299973
17BUB11.99461642
18SMG11.92938250
19NEK11.91914423
20EPHB11.89481408
21PTK2B1.87651666
22MAP3K131.77081503
23TGFBR11.74701245
24ERN11.70763034
25LRRK21.67078782
26LMTK21.55214724
27BRSK11.53471524
28FGFR41.53199916
29SIK11.49446246
30SCYL21.44995555
31PRKD21.42324638
32PAK41.37220934
33MAP4K11.36313453
34MAP2K31.31299344
35STK101.28969916
36TSSK61.28953292
37CDK81.27623763
38UHMK11.26701077
39KIT1.21643613
40MST41.16816998
41ERBB31.16309394
42TYK21.15752662
43ROCK21.15244395
44CDC42BPA1.09434529
45CDK191.09241688
46MAP3K111.08510734
47SGK21.08199160
48ILK1.06748701
49PRKD31.05767723
50TXK1.05600432
51VRK11.05058050
52NEK21.02768268
53CDK121.01988756
54NME11.01569423
55MAP2K21.00471327
56RIPK10.98703168
57CCNB10.97014758
58SGK4940.95911990
59SGK2230.95911990
60MAP3K30.95544803
61PHKG10.94957212
62PHKG20.94957212
63ZAP700.93897025
64TESK20.92566613
65EPHA30.92185823
66SGK30.91908511
67CSF1R0.91734246
68MAP2K60.91709131
69TAOK20.91278257
70MARK20.90789493
71HIPK20.89237544
72SIK20.89140642
73PTK60.87795554
74TYRO30.86377840
75RPS6KA20.85672510
76NLK0.85457144
77CDC70.84914137
78WEE10.83212898
79RPS6KL10.82147119
80RPS6KC10.82147119
81AKT20.78983790
82MYLK0.78816778
83RPS6KA60.75763840
84PRKCI0.74994541
85ALK0.73341925
86CSNK1G30.73314042
87ROCK10.73307717
88MAP3K10.71153725
89TLK10.70960546
90CLK10.69812480
91TNK20.69499946
92CAMKK10.68972265
93CSNK1A1L0.66773208
94BTK0.65518384
95MAPKAPK20.65157149
96GRK60.62015607
97AURKA0.61909599
98OBSCN0.61239794
99KDR0.61050051
100PRKD10.59695553
101PDPK10.59121982
102KSR20.58355144
103TAOK10.57981856
104TESK10.57563682
105NTRK10.56744238
106MAPK110.55663297
107MAP3K80.55199990
108DYRK30.55029085
109MTOR0.54751182
110GSK3A0.54192213
111CDK40.54094205
112NME20.52139305
113BMX0.50765832
114ICK0.49003019
115PRKCH0.48613862
116DAPK20.48312816
117ARAF0.48225431
118MAP3K70.48198571
119PKN10.47472380
120PDK20.46469717
121RIPK40.46136964
122STK40.45442052
123PDGFRB0.45104029
124TNIK0.44267211
125BCKDK0.44065495
126DMPK0.43941898
127IRAK30.43658813
128RET0.43325172
129AURKB0.42885637
130SYK0.41972610
131CSK0.41968536
132MAPK120.41583775
133STK380.41544349
134EIF2AK10.41111246
135RPS6KA10.41059591
136PIM20.40980477
137PDGFRA0.40787071
138LIMK10.40648363
139ERBB20.40337573
140FYN0.39070725
141FES0.37046350
142PDK10.36925385
143HCK0.34941890
144LCK0.34185735
145TBK10.32296067
146MAPK150.32154366
147MAPK70.31803454
148DYRK1B0.31654227
149NTRK20.30718741
150YES10.30047702
151CDK11A0.29109266
152PRKG20.27200024
153MAP3K60.24807987
154MAPK10.24782885
155EPHA20.24703918
156MELK0.24437293
157FGFR30.24435607
158CDK150.23241670

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.72130285
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.14225029
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.76861094
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.44050335
5Mismatch repair_Homo sapiens_hsa034302.40165863
6Ribosome_Homo sapiens_hsa030102.35654570
7Base excision repair_Homo sapiens_hsa034102.32519219
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22420058
9Nucleotide excision repair_Homo sapiens_hsa034202.04031517
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00076709
11Spliceosome_Homo sapiens_hsa030401.95555953
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.79548871
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73741908
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71466007
15Cell cycle_Homo sapiens_hsa041101.70883520
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68852680
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62273489
18Chronic myeloid leukemia_Homo sapiens_hsa052201.61631945
19Sulfur relay system_Homo sapiens_hsa041221.60228138
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54937138
21Thyroid cancer_Homo sapiens_hsa052161.53727320
22Non-small cell lung cancer_Homo sapiens_hsa052231.49570382
23Homologous recombination_Homo sapiens_hsa034401.49545064
24AMPK signaling pathway_Homo sapiens_hsa041521.49500236
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.48442137
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43255456
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36665546
28Gastric acid secretion_Homo sapiens_hsa049711.34798177
29Dilated cardiomyopathy_Homo sapiens_hsa054141.30983800
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25059148
31Endometrial cancer_Homo sapiens_hsa052131.24662019
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18496588
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16543549
34Parkinsons disease_Homo sapiens_hsa050121.16413889
35Cardiac muscle contraction_Homo sapiens_hsa042601.16115403
36Bladder cancer_Homo sapiens_hsa052191.12997674
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11231859
38N-Glycan biosynthesis_Homo sapiens_hsa005101.10648405
39RNA transport_Homo sapiens_hsa030131.09724826
40Systemic lupus erythematosus_Homo sapiens_hsa053221.08935671
41Glutathione metabolism_Homo sapiens_hsa004801.08839622
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08260244
43Viral myocarditis_Homo sapiens_hsa054161.07474592
44HTLV-I infection_Homo sapiens_hsa051661.06973410
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04325503
46Acute myeloid leukemia_Homo sapiens_hsa052211.01747243
47Glucagon signaling pathway_Homo sapiens_hsa049221.01434762
48Fatty acid degradation_Homo sapiens_hsa000711.01282339
49Alcoholism_Homo sapiens_hsa050341.00939083
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.00552595
51p53 signaling pathway_Homo sapiens_hsa041150.99754029
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.97981238
53Viral carcinogenesis_Homo sapiens_hsa052030.92281667
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92041696
55Hepatitis C_Homo sapiens_hsa051600.91824745
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91391250
57Chemical carcinogenesis_Homo sapiens_hsa052040.91120016
58* Osteoclast differentiation_Homo sapiens_hsa043800.90761077
59Phagosome_Homo sapiens_hsa041450.90548783
60Notch signaling pathway_Homo sapiens_hsa043300.88339354
61Carbon metabolism_Homo sapiens_hsa012000.88287355
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.87680865
63Gap junction_Homo sapiens_hsa045400.86602217
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85920349
65Cocaine addiction_Homo sapiens_hsa050300.85608852
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85526355
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85362719
68VEGF signaling pathway_Homo sapiens_hsa043700.85251819
69Rap1 signaling pathway_Homo sapiens_hsa040150.84889432
70Pyrimidine metabolism_Homo sapiens_hsa002400.81618670
71Shigellosis_Homo sapiens_hsa051310.81616358
72Small cell lung cancer_Homo sapiens_hsa052220.81349568
73Apoptosis_Homo sapiens_hsa042100.81236585
74Thyroid hormone synthesis_Homo sapiens_hsa049180.76839941
75One carbon pool by folate_Homo sapiens_hsa006700.76718398
76Glioma_Homo sapiens_hsa052140.76200332
77Chemokine signaling pathway_Homo sapiens_hsa040620.76167969
78Estrogen signaling pathway_Homo sapiens_hsa049150.76129466
79Proteasome_Homo sapiens_hsa030500.75853793
80Other glycan degradation_Homo sapiens_hsa005110.75793433
81Endocytosis_Homo sapiens_hsa041440.75681016
82Inositol phosphate metabolism_Homo sapiens_hsa005620.74146092
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.73912147
84Melanogenesis_Homo sapiens_hsa049160.73110207
85mTOR signaling pathway_Homo sapiens_hsa041500.72986611
86Colorectal cancer_Homo sapiens_hsa052100.72205822
87* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71969155
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71755846
89Prion diseases_Homo sapiens_hsa050200.71002572
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.70050120
91Biosynthesis of amino acids_Homo sapiens_hsa012300.69871174
92Renal cell carcinoma_Homo sapiens_hsa052110.69553047
93mRNA surveillance pathway_Homo sapiens_hsa030150.68545651
94Prostate cancer_Homo sapiens_hsa052150.68195492
95Salmonella infection_Homo sapiens_hsa051320.66936517
96Lysosome_Homo sapiens_hsa041420.66209063
97Platelet activation_Homo sapiens_hsa046110.65051369
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64255844
99* Toxoplasmosis_Homo sapiens_hsa051450.64082542
100ErbB signaling pathway_Homo sapiens_hsa040120.63660291
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62897008
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62778866
103RNA degradation_Homo sapiens_hsa030180.62711376
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62583092
105Primary immunodeficiency_Homo sapiens_hsa053400.61246674
106B cell receptor signaling pathway_Homo sapiens_hsa046620.60495149
107Galactose metabolism_Homo sapiens_hsa000520.60494330
108Pentose phosphate pathway_Homo sapiens_hsa000300.59347397
109Cholinergic synapse_Homo sapiens_hsa047250.58635695
110Insulin secretion_Homo sapiens_hsa049110.58397924
111Regulation of autophagy_Homo sapiens_hsa041400.57671472
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57324055
113Alzheimers disease_Homo sapiens_hsa050100.56502481
114Tight junction_Homo sapiens_hsa045300.56207715
115Dopaminergic synapse_Homo sapiens_hsa047280.55885192
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54341523
117Ras signaling pathway_Homo sapiens_hsa040140.53262650
118* NF-kappa B signaling pathway_Homo sapiens_hsa040640.53003376
119GnRH signaling pathway_Homo sapiens_hsa049120.52375239
120Fructose and mannose metabolism_Homo sapiens_hsa000510.52236746
121Vibrio cholerae infection_Homo sapiens_hsa051100.51968762
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51817438
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.51426284
124* TNF signaling pathway_Homo sapiens_hsa046680.51205897
125Proteoglycans in cancer_Homo sapiens_hsa052050.50919778
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49878068
127HIF-1 signaling pathway_Homo sapiens_hsa040660.49669265
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49368840
129Long-term potentiation_Homo sapiens_hsa047200.49190922
130Graft-versus-host disease_Homo sapiens_hsa053320.49165445
131Insulin signaling pathway_Homo sapiens_hsa049100.49074682
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48430503
133Choline metabolism in cancer_Homo sapiens_hsa052310.48239484
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48008237
135MicroRNAs in cancer_Homo sapiens_hsa052060.47846120
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47565300
137Bile secretion_Homo sapiens_hsa049760.47370849
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47172098
139Amoebiasis_Homo sapiens_hsa051460.45959065
140Amphetamine addiction_Homo sapiens_hsa050310.45813957
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45770166
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44757109
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44632737
144Focal adhesion_Homo sapiens_hsa045100.44219330
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44018343
146Phenylalanine metabolism_Homo sapiens_hsa003600.42990853
147Hepatitis B_Homo sapiens_hsa051610.39939898
148Oxidative phosphorylation_Homo sapiens_hsa001900.39909663
149Pancreatic cancer_Homo sapiens_hsa052120.37456780
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37364764
151FoxO signaling pathway_Homo sapiens_hsa040680.36535596
152Non-homologous end-joining_Homo sapiens_hsa034500.35258660
153* MAPK signaling pathway_Homo sapiens_hsa040100.34867354
154T cell receptor signaling pathway_Homo sapiens_hsa046600.34413770
155Insulin resistance_Homo sapiens_hsa049310.33950621
156Axon guidance_Homo sapiens_hsa043600.33814642

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