TAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)3.83973257
2growth hormone receptor signaling pathway (GO:0060396)3.64429968
3cytoplasmic mRNA processing body assembly (GO:0033962)3.58713409
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56081132
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56081132
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.56081132
7modulation by symbiont of host immune response (GO:0052553)3.56081132
8positive regulation by symbiont of host defense response (GO:0052509)3.56081132
9modulation by symbiont of host defense response (GO:0052031)3.56081132
10histone H3-K36 demethylation (GO:0070544)3.46170506
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42147890
12positive regulation of gamma-delta T cell activation (GO:0046645)3.38261379
13regulation of B cell receptor signaling pathway (GO:0050855)3.34460647
14response to peptidoglycan (GO:0032494)3.32129861
15cellular extravasation (GO:0045123)3.21408849
16positive regulation of histone deacetylation (GO:0031065)3.18642439
17negative T cell selection (GO:0043383)3.14485862
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14238443
19germinal center formation (GO:0002467)3.13512247
20cellular response to growth hormone stimulus (GO:0071378)3.12008458
21positive regulation of interferon-alpha production (GO:0032727)3.10073174
22detection of molecule of bacterial origin (GO:0032490)3.08136277
23detection of other organism (GO:0098543)3.07696983
24negative regulation of cell killing (GO:0031342)3.06983889
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.06983889
26regulation of interferon-alpha production (GO:0032647)3.06441572
27regulation of gamma-delta T cell differentiation (GO:0045586)3.06080509
28negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04491015
29negative regulation of T-helper cell differentiation (GO:0045623)3.04491015
30regulation of interferon-beta biosynthetic process (GO:0045357)3.01373784
31positive regulation of granulocyte differentiation (GO:0030854)3.00991507
32mitotic sister chromatid cohesion (GO:0007064)2.99203769
33leukocyte aggregation (GO:0070486)2.98518404
34JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96375519
35negative regulation of interleukin-12 production (GO:0032695)2.95169420
36positive T cell selection (GO:0043368)2.94571240
37negative regulation of T cell mediated immunity (GO:0002710)2.92761886
38response to interleukin-15 (GO:0070672)2.90312361
39T cell selection (GO:0045058)2.84670284
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83151927
41phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80117087
42detection of bacterium (GO:0016045)2.79611297
43regulation of gamma-delta T cell activation (GO:0046643)2.79239282
44detection of external biotic stimulus (GO:0098581)2.78746820
45positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76066339
46thymic T cell selection (GO:0045061)2.75948474
47regulation of interleukin-12 biosynthetic process (GO:0045075)2.74579379
48B cell receptor signaling pathway (GO:0050853)2.71922516
49positive regulation of chemokine biosynthetic process (GO:0045080)2.70377915
50response to host immune response (GO:0052572)2.67275287
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67275287
52hypotonic response (GO:0006971)2.66782491
53regulation of T-helper 2 cell differentiation (GO:0045628)2.66466985
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65809123
55regulation of tolerance induction (GO:0002643)2.63740122
56regulation of histone H3-K27 methylation (GO:0061085)2.63573343
57NLS-bearing protein import into nucleus (GO:0006607)2.62931168
58regulation of T cell tolerance induction (GO:0002664)2.62429315
59tolerance induction (GO:0002507)2.61663337
60macrophage activation involved in immune response (GO:0002281)2.59403231
61positive regulation of p38MAPK cascade (GO:1900745)2.57878376
62positive regulation of tolerance induction (GO:0002645)2.57006435
63detection of biotic stimulus (GO:0009595)2.56232513
64positive regulation of Rap GTPase activity (GO:0032854)2.55740669
65regulation of necroptotic process (GO:0060544)2.55713714
66embryonic process involved in female pregnancy (GO:0060136)2.53959389
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50526965
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50526965
69histone H3-K9 demethylation (GO:0033169)2.49740603
70histone H3-K4 trimethylation (GO:0080182)2.49735401
71regulation of T-helper 1 cell differentiation (GO:0045625)2.49300072
72protein localization to endosome (GO:0036010)2.46304996
73negative regulation of lymphocyte mediated immunity (GO:0002707)2.46043946
74positive regulation of B cell differentiation (GO:0045579)2.44575493
75regulation of interleukin-2 biosynthetic process (GO:0045076)2.43608237
76B cell homeostasis (GO:0001782)2.43327460
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.42219001
78natural killer cell differentiation (GO:0001779)2.41289145
79cell adhesion mediated by integrin (GO:0033627)2.40463059
80histone lysine demethylation (GO:0070076)2.40118038
81neutrophil activation involved in immune response (GO:0002283)2.39214585
82antigen processing and presentation via MHC class Ib (GO:0002475)2.38755892
83regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.37457813
84I-kappaB phosphorylation (GO:0007252)2.37258768
85positive regulation of interferon-beta production (GO:0032728)2.36889858
86regulation of macrophage cytokine production (GO:0010935)2.35944199
87positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.35807289
88cellular response to type I interferon (GO:0071357)2.35443745
89type I interferon signaling pathway (GO:0060337)2.35443745
90corticosteroid receptor signaling pathway (GO:0031958)2.35282007
91activated T cell proliferation (GO:0050798)2.34562674
92regulation of membrane protein ectodomain proteolysis (GO:0051043)2.34450808
93cellular response to interleukin-15 (GO:0071350)2.34445775
94RNA stabilization (GO:0043489)2.34139673
95mRNA stabilization (GO:0048255)2.34139673
96response to type I interferon (GO:0034340)2.33436251
97positive regulation of natural killer cell differentiation (GO:0032825)2.33421232
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32507761
99T cell migration (GO:0072678)2.32303030
100substrate-dependent cell migration (GO:0006929)2.32045227
101immunoglobulin mediated immune response (GO:0016064)2.31746896
102negative regulation of B cell proliferation (GO:0030889)2.30506247
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30458197
104megakaryocyte development (GO:0035855)2.30362914
105interferon-gamma-mediated signaling pathway (GO:0060333)2.29880173
106NIK/NF-kappaB signaling (GO:0038061)2.29718527
107defense response to protozoan (GO:0042832)2.29412473
108regulation of regulatory T cell differentiation (GO:0045589)2.29381060
109positive regulation of macrophage differentiation (GO:0045651)2.28507585
110glucocorticoid receptor signaling pathway (GO:0042921)2.28303545
111definitive hemopoiesis (GO:0060216)2.28273444
112histone demethylation (GO:0016577)2.27599021
113positive thymic T cell selection (GO:0045059)2.27180035
114positive regulation of cellular amide metabolic process (GO:0034250)2.26881530
115response to muramyl dipeptide (GO:0032495)2.26483207
116lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25996551
117T cell homeostasis (GO:0043029)2.25967774
118positive regulation of interleukin-2 production (GO:0032743)2.25812618
119myeloid cell activation involved in immune response (GO:0002275)2.24814810
120mRNA transcription (GO:0009299)2.24614856
1213-UTR-mediated mRNA stabilization (GO:0070935)2.23761745
122positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23653289
123cellular response to interferon-alpha (GO:0035457)2.23309412
124regulation of RNA export from nucleus (GO:0046831)2.22089445
125cortical actin cytoskeleton organization (GO:0030866)2.20325499
126positive regulation of protein import into nucleus, translocation (GO:0033160)2.19860229
127positive regulation of protein deacetylation (GO:0090312)2.19080723
128regulation of nucleobase-containing compound transport (GO:0032239)2.18707368
129granulocyte activation (GO:0036230)2.18213475
130negative regulation of fatty acid transport (GO:2000192)2.18138573
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.18092089
132T-helper 1 type immune response (GO:0042088)2.17919066
133mesodermal cell differentiation (GO:0048333)2.16646876
134antigen processing and presentation of endogenous antigen (GO:0019883)2.16463941
135regulation of B cell differentiation (GO:0045577)2.16436100
136leukocyte cell-cell adhesion (GO:0007159)2.15256780
137positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.14654549
138neutrophil activation (GO:0042119)2.14032047
139JAK-STAT cascade (GO:0007259)2.11883852
140germ cell migration (GO:0008354)2.11522080
141establishment of endothelial barrier (GO:0061028)2.11303455
142myeloid dendritic cell differentiation (GO:0043011)2.10775467
143positive regulation of mRNA catabolic process (GO:0061014)2.09181988
144embryonic retina morphogenesis in camera-type eye (GO:0060059)2.08992862
145regulation of vitamin D biosynthetic process (GO:0060556)2.08426617
146response to laminar fluid shear stress (GO:0034616)2.07922666
147positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.07457610
148hepatocyte apoptotic process (GO:0097284)2.04344903
149tyrosine phosphorylation of STAT protein (GO:0007260)2.03832710
150coronary vasculature morphogenesis (GO:0060977)2.03752792
151insulin-like growth factor receptor signaling pathway (GO:0048009)2.03737208
152hippo signaling (GO:0035329)2.03155000
153response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.01933749
154response to host (GO:0075136)2.01933749
155response to host defenses (GO:0052200)2.01933749
156pre-miRNA processing (GO:0031054)2.01529204
157positive regulation vascular endothelial growth factor production (GO:0010575)1.99095319
158regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)1.98818880
159positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO1.98818880
160positive regulation of SMAD protein import into nucleus (GO:0060391)1.98425679
161regulation of chemokine biosynthetic process (GO:0045073)1.97136364
162negative thymic T cell selection (GO:0045060)1.96739978
163nuclear pore complex assembly (GO:0051292)1.96551837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.50290391
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.41373737
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.40179230
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79621422
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.64806560
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.28172911
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.89730308
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.64803631
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62216134
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56477993
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53566920
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.51153571
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.42253932
14MYC_22102868_ChIP-Seq_BL_Human2.34993332
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25714616
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20836771
17SCL_19346495_ChIP-Seq_HPC-7_Human2.19480463
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15143847
19RUNX_20019798_ChIP-Seq_JUKART_Human2.14044439
20TCF7_22412390_ChIP-Seq_EML_Mouse2.12349918
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07457223
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04091498
23MAF_26560356_Chip-Seq_TH1_Human1.92661807
24E2F7_22180533_ChIP-Seq_HELA_Human1.90949541
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.88842470
26MYB_26560356_Chip-Seq_TH2_Human1.88230738
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87724626
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86502726
29VDR_21846776_ChIP-Seq_THP-1_Human1.85062085
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78575441
31CLOCK_20551151_ChIP-Seq_293T_Human1.74656714
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.73763804
33KDM2B_26808549_Chip-Seq_DND41_Human1.71083519
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70058901
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65649697
36* MYB_26560356_Chip-Seq_TH1_Human1.63004320
37* VDR_24763502_ChIP-Seq_THP-1_Human1.61296282
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.58959247
39UTX_26944678_Chip-Seq_JUKART_Human1.55573587
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51666585
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51560049
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48879937
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.47422065
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47067307
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43544522
46SPI1_23127762_ChIP-Seq_K562_Human1.39223082
47* PU_27001747_Chip-Seq_BMDM_Mouse1.37429197
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35027170
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33594269
50VDR_24787735_ChIP-Seq_THP-1_Human1.33260573
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33110915
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33110915
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33110915
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31467832
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29974893
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29162640
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.28618583
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28013369
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27977418
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.27902362
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26866453
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26765954
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.25617233
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25510764
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25311956
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24921856
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24802830
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21591885
69GATA1_19941826_ChIP-Seq_K562_Human1.21113921
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.21099591
71* BRD4_25478319_ChIP-Seq_HGPS_Human1.19015314
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18942920
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.18532324
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.18151669
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17881383
76GATA3_27048872_Chip-Seq_THYMUS_Human1.17184943
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16401666
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15864818
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15692787
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15558526
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15487478
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.14951122
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14542962
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13355322
85SPI1_23547873_ChIP-Seq_NB4_Human1.13105112
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12169314
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12169314
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10407419
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10133356
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.09837505
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09819760
92* NCOR1_26117541_ChIP-Seq_K562_Human1.08934104
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08925698
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08285489
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08071799
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07968092
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07401783
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07074180
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06828710
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.06777692
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05882445
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04541943
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02515866
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.02318510
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01558064
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01548399
107GATA2_19941826_ChIP-Seq_K562_Human1.01508016
108CJUN_26792858_Chip-Seq_BT549_Human1.01506188
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.00981103
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00636942
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.00621536
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99455545
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98791399
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.97387005
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.97387005
116GATA1_22025678_ChIP-Seq_K562_Human0.96843129
117* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93950000
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87586947
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84513522
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84006415
121MAF_26560356_Chip-Seq_TH2_Human0.83891788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.13103335
2MP0003303_peritoneal_inflammation3.06111641
3MP0003705_abnormal_hypodermis_morpholog2.79702455
4MP0005076_abnormal_cell_differentiation2.44018681
5MP0010352_gastrointestinal_tract_polyps2.41110622
6MP0005451_abnormal_body_composition2.03390705
7MP0003566_abnormal_cell_adhesion1.95687508
8MP0003436_decreased_susceptibility_to1.91997238
9MP0002006_tumorigenesis1.90287068
10MP0001835_abnormal_antigen_presentation1.88363283
11MP0009278_abnormal_bone_marrow1.85920043
12MP0005387_immune_system_phenotype1.85567038
13MP0001790_abnormal_immune_system1.85567038
14MP0000733_abnormal_muscle_development1.74347095
15MP0001800_abnormal_humoral_immune1.73523727
16MP0004808_abnormal_hematopoietic_stem1.71819337
17MP0005000_abnormal_immune_tolerance1.69417311
18MP0003191_abnormal_cellular_cholesterol1.68685278
19MP0002166_altered_tumor_susceptibility1.68618913
20MP0008057_abnormal_DNA_replication1.67624065
21MP0000685_abnormal_immune_system1.67186555
22MP0002452_abnormal_antigen_presenting1.64325330
23MP0002419_abnormal_innate_immunity1.60708581
24MP0003448_altered_tumor_morphology1.60095889
25MP0008438_abnormal_cutaneous_collagen1.59223357
26MP0005671_abnormal_response_to1.59139239
27MP0009785_altered_susceptibility_to1.57001959
28MP0006054_spinal_hemorrhage1.54241464
29MP0004947_skin_inflammation1.52370751
30MP0010307_abnormal_tumor_latency1.52130004
31MP0006082_CNS_inflammation1.50661981
32MP0002723_abnormal_immune_serum1.50005384
33MP0008004_abnormal_stomach_pH1.48854223
34MP0002877_abnormal_melanocyte_morpholog1.48775841
35MP0004185_abnormal_adipocyte_glucose1.45490495
36MP0005025_abnormal_response_to1.45075451
37MP0003656_abnormal_erythrocyte_physiolo1.41151141
38MP0001819_abnormal_immune_cell1.41113174
39MP0002420_abnormal_adaptive_immunity1.40949609
40MP0004510_myositis1.40614807
41MP0003828_pulmonary_edema1.40178201
42MP0002396_abnormal_hematopoietic_system1.38455237
43MP0005409_darkened_coat_color1.37808319
44MP0005464_abnormal_platelet_physiology1.36776457
45MP0010234_abnormal_vibrissa_follicle1.33661271
46MP0005310_abnormal_salivary_gland1.33634279
47MP0003172_abnormal_lysosome_physiology1.32945711
48MP0002398_abnormal_bone_marrow1.32822127
49MP0001849_ear_inflammation1.29345168
50MP0005023_abnormal_wound_healing1.28718960
51MP0003091_abnormal_cell_migration1.27063200
52MP0005397_hematopoietic_system_phenotyp1.26424207
53MP0001545_abnormal_hematopoietic_system1.26424207
54MP0010155_abnormal_intestine_physiology1.26147820
55MP0003866_abnormal_defecation1.25097296
56MP0003045_fibrosis1.23184089
57MP0001873_stomach_inflammation1.22670269
58MP0003183_abnormal_peptide_metabolism1.22280013
59MP0002405_respiratory_system_inflammati1.21828406
60MP0002148_abnormal_hypersensitivity_rea1.21729690
61MP0003763_abnormal_thymus_physiology1.21662909
62MP0002998_abnormal_bone_remodeling1.20684965
63MP0001533_abnormal_skeleton_physiology1.19441407
64MP0000858_altered_metastatic_potential1.19179704
65MP0000716_abnormal_immune_system1.18799410
66MP0003453_abnormal_keratinocyte_physiol1.15515082
67MP0004084_abnormal_cardiac_muscle1.14287779
68MP0000767_abnormal_smooth_muscle1.12572318
69MP0005666_abnormal_adipose_tissue1.11918876
70MP0001915_intracranial_hemorrhage1.11861559
71MP0009333_abnormal_splenocyte_physiolog1.11162922
72MP0003279_aneurysm1.10126098
73MP0000569_abnormal_digit_pigmentation1.09142548
74MP0010630_abnormal_cardiac_muscle1.07078045
75MP0001845_abnormal_inflammatory_respons1.07004491
76MP0010368_abnormal_lymphatic_system1.06407648
77MP0000703_abnormal_thymus_morphology1.06308571
78MP0002722_abnormal_immune_system1.05831019
79MP0000343_altered_response_to1.01389490
80MP0003724_increased_susceptibility_to1.01122615
81MP0002925_abnormal_cardiovascular_devel1.00583534
82MP0000689_abnormal_spleen_morphology1.00386661
83MP0004381_abnormal_hair_follicle1.00068025
84MP0004197_abnormal_fetal_growth/weight/0.99802276
85MP0004883_abnormal_blood_vessel0.98428672
86MP0008961_abnormal_basal_metabolism0.98043755
87MP0009053_abnormal_anal_canal0.97815769
88MP0004036_abnormal_muscle_relaxation0.97765939
89MP0001879_abnormal_lymphatic_vessel0.96152931
90MP0002429_abnormal_blood_cell0.95585358
91MP0002086_abnormal_extraembryonic_tissu0.95267979
92MP0005164_abnormal_response_to0.94184456
93MP0004264_abnormal_extraembryonic_tissu0.92928340
94MP0001853_heart_inflammation0.92061912
95MP0001851_eye_inflammation0.91493861
96MP0005167_abnormal_blood-brain_barrier0.90872754
97MP0009384_cardiac_valve_regurgitation0.90239103
98MP0005058_abnormal_lysosome_morphology0.90118220
99MP0003567_abnormal_fetal_cardiomyocyte0.89922392
100MP0010678_abnormal_skin_adnexa0.89400438
101MP0002933_joint_inflammation0.89398865
102MP0002009_preneoplasia0.89396854
103MP0003075_altered_response_to0.88853634
104MP0000465_gastrointestinal_hemorrhage0.86149197
105MP0009115_abnormal_fat_cell0.84710402
106MP0005275_abnormal_skin_tensile0.84308304
107MP0004272_abnormal_basement_membrane0.82678968
108MP0005166_decreased_susceptibility_to0.82584063
109* MP0002128_abnormal_blood_circulation0.82516803
110MP0008469_abnormal_protein_level0.81978366
111MP0009764_decreased_sensitivity_to0.81437120
112MP0002088_abnormal_embryonic_growth/wei0.80284350
113MP0001614_abnormal_blood_vessel0.80034164
114MP0008260_abnormal_autophagy0.80021375
115MP0003984_embryonic_growth_retardation0.79838301
116MP0000249_abnormal_blood_vessel0.79344211
117MP0002138_abnormal_hepatobiliary_system0.77231166
118MP0000383_abnormal_hair_follicle0.77042723
119MP0003795_abnormal_bone_structure0.74802187
120MP0003252_abnormal_bile_duct0.74276390
121MP0005390_skeleton_phenotype0.74138788
122MP0004484_altered_response_of0.74131492
123MP0004130_abnormal_muscle_cell0.73485671
124MP0002332_abnormal_exercise_endurance0.73241163
125MP0005621_abnormal_cell_physiology0.73012828
126MP0002277_abnormal_respiratory_mucosa0.71317172

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)3.22263435
2Eczematoid dermatitis (HP:0000976)3.17805832
3Abnormality of the fingertips (HP:0001211)3.08768090
4Hematochezia (HP:0002573)2.83895083
5Stomatitis (HP:0010280)2.80404034
6Myositis (HP:0100614)2.77870050
7Shallow orbits (HP:0000586)2.68867083
8Syringomyelia (HP:0003396)2.68051135
9Spinal cord lesions (HP:0100561)2.68051135
10Orchitis (HP:0100796)2.65876688
11Epistaxis (HP:0000421)2.61409036
12Osteolytic defects of the hand bones (HP:0009699)2.55244342
13Osteolytic defects of the phalanges of the hand (HP:0009771)2.55244342
14Recurrent bacterial skin infections (HP:0005406)2.54747998
15Aortic aneurysm (HP:0004942)2.54592852
16Volvulus (HP:0002580)2.51569729
17Autoimmune thrombocytopenia (HP:0001973)2.51382297
18Abnormal delayed hypersensitivity skin test (HP:0002963)2.50979535
19Subacute progressive viral hepatitis (HP:0006572)2.49062594
20Recurrent viral infections (HP:0004429)2.46431838
21Papillary thyroid carcinoma (HP:0002895)2.45252288
22Macroorchidism (HP:0000053)2.45069549
23Increased density of long bones (HP:0006392)2.44538341
24Cerebral aneurysm (HP:0004944)2.44009424
25Recurrent abscess formation (HP:0002722)2.43453580
26Arterial thrombosis (HP:0004420)2.42502512
27Persistence of primary teeth (HP:0006335)2.41520501
28Autoimmune hemolytic anemia (HP:0001890)2.40430449
29Cellulitis (HP:0100658)2.39619291
30Abnormal platelet volume (HP:0011876)2.36223434
31Peritonitis (HP:0002586)2.31713110
32Mitral valve prolapse (HP:0001634)2.30294757
33Recurrent cutaneous fungal infections (HP:0011370)2.30074180
34Chronic mucocutaneous candidiasis (HP:0002728)2.30074180
35Recurrent fungal infections (HP:0002841)2.29870290
36Myocardial infarction (HP:0001658)2.29159179
37Spondylolisthesis (HP:0003302)2.28802828
38Retrobulbar optic neuritis (HP:0100654)2.27843561
39Optic neuritis (HP:0100653)2.27843561
40Spontaneous hematomas (HP:0007420)2.23076790
41Gingivitis (HP:0000230)2.21525479
42Increased mean platelet volume (HP:0011877)2.12829642
43Asymmetry of the thorax (HP:0001555)2.12776834
44T lymphocytopenia (HP:0005403)2.10400460
45Keratoconjunctivitis (HP:0001096)2.09298496
46Meningitis (HP:0001287)2.08671899
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06240489
48Short 4th metacarpal (HP:0010044)2.06240489
49Hemoptysis (HP:0002105)2.06053497
50Mediastinal lymphadenopathy (HP:0100721)2.05913703
51Neonatal hypoglycemia (HP:0001998)2.03566014
52Abnormality of the peritoneum (HP:0002585)2.03340860
53Acute myeloid leukemia (HP:0004808)2.02178087
54Disproportionate tall stature (HP:0001519)2.01329958
55Abnormality of T cell number (HP:0011839)2.00788829
56Obstructive sleep apnea (HP:0002870)2.00626813
57Narrow palate (HP:0000189)2.00372941
58Long eyelashes (HP:0000527)1.99900937
59Protrusio acetabuli (HP:0003179)1.99870864
60Rectal prolapse (HP:0002035)1.99823465
61Increased cerebral lipofuscin (HP:0011813)1.94862315
62Recurrent gram-negative bacterial infections (HP:0005420)1.94639785
63Disinhibition (HP:0000734)1.94251222
64Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93503508
65Chest pain (HP:0100749)1.92916540
66Muscle fiber splitting (HP:0003555)1.92150740
67Aortic dissection (HP:0002647)1.91908686
68Pustule (HP:0200039)1.91181208
69Deep philtrum (HP:0002002)1.89908015
70Aneurysm (HP:0002617)1.89796524
71Abnormality of the 4th metacarpal (HP:0010012)1.89114761
72Inflammation of the large intestine (HP:0002037)1.88986611
73Menorrhagia (HP:0000132)1.88908668
74Abnormality of the nasal septum (HP:0000419)1.88877793
75Abnormality of T cells (HP:0002843)1.88856575
76Vasculitis (HP:0002633)1.87715652
77Gastrointestinal inflammation (HP:0004386)1.85748496
78Gingival bleeding (HP:0000225)1.85586581
79Ulnar bowing (HP:0003031)1.85029537
80Encephalitis (HP:0002383)1.84866729
81Viral hepatitis (HP:0006562)1.82971394
82Colitis (HP:0002583)1.82511574
83Slow saccadic eye movements (HP:0000514)1.82314935
84Interstitial pulmonary disease (HP:0006530)1.81376295
85Truncal obesity (HP:0001956)1.80314671
86Segmental peripheral demyelination/remyelination (HP:0003481)1.80281464
87Thyroiditis (HP:0100646)1.78537331
88Thin bony cortex (HP:0002753)1.78332796
89Flat acetabular roof (HP:0003180)1.77984351
90Dilatation of the ascending aorta (HP:0005111)1.77760154
91Periodontitis (HP:0000704)1.76486620
92Esophageal varix (HP:0002040)1.75322260
93Asymmetric septal hypertrophy (HP:0001670)1.74927702
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74874553
95Abnormality of the lumbar spine (HP:0100712)1.72743227
96Leukocytosis (HP:0001974)1.71780083
97Hyporeflexia of lower limbs (HP:0002600)1.71488722
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.71255542
99Curly hair (HP:0002212)1.70970341
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.70457497
101Osteomyelitis (HP:0002754)1.70251990
102Cranial hyperostosis (HP:0004437)1.70082777
103Arterial tortuosity (HP:0005116)1.69853801
104Abnormality of the endocardium (HP:0004306)1.69742042
105Recurrent skin infections (HP:0001581)1.69734640
106Cutis marmorata (HP:0000965)1.69292097
107Exostoses (HP:0100777)1.69024199
108Deviation of the hallux (HP:0010051)1.68646880
109Abnormality of skeletal muscle fiber size (HP:0012084)1.68570564
110Pulmonary embolism (HP:0002204)1.67659791
111Coarse hair (HP:0002208)1.67655334
112Gangrene (HP:0100758)1.67630330
113Elevated erythrocyte sedimentation rate (HP:0003565)1.67389104
114Vascular tortuosity (HP:0004948)1.66442962
115Absent frontal sinuses (HP:0002688)1.66209610
116Dislocated radial head (HP:0003083)1.66189979
117Purpura (HP:0000979)1.66123762
118Gastrointestinal infarctions (HP:0005244)1.65646034
119Thickened calvaria (HP:0002684)1.65362549
120Transitional cell carcinoma of the bladder (HP:0006740)1.65083386
121Thick eyebrow (HP:0000574)1.64671685
122Overgrowth (HP:0001548)1.64623795
123Craniofacial hyperostosis (HP:0004493)1.64476310
124Chronic diarrhea (HP:0002028)1.63307173
125Hypoplastic ischia (HP:0003175)1.63027327
126Papilledema (HP:0001085)1.62276774
127Hallux valgus (HP:0001822)1.61994842
128Difficulty running (HP:0009046)1.61799788
129Pulmonary infiltrates (HP:0002113)1.61081242
130Nemaline bodies (HP:0003798)1.61051769
131Deviation of the thumb (HP:0009603)1.61032594
132Broad metatarsal (HP:0001783)1.60563637
133Blepharitis (HP:0000498)1.59133926
134Amaurosis fugax (HP:0100576)1.58871710
135Cervical subluxation (HP:0003308)1.57740431
136Fatigue (HP:0012378)1.57711181
137Increased IgE level (HP:0003212)1.57658028
138Limited elbow extension (HP:0001377)1.57390161
139Abnormality of macrophages (HP:0004311)1.56352584
140Keratoconjunctivitis sicca (HP:0001097)1.56054367
141Camptodactyly of toe (HP:0001836)1.54100192
142Abnormality of the radial head (HP:0003995)1.53982684
143Trigonocephaly (HP:0000243)1.53546109
144Enlarged penis (HP:0000040)1.53434404
145Thick nail (HP:0001805)1.53135776
146Hyperacusis (HP:0010780)1.52329357
147Premature rupture of membranes (HP:0001788)1.51889975
148Low anterior hairline (HP:0000294)1.50853478
149Ureteral obstruction (HP:0006000)1.49949476
150Tibial bowing (HP:0002982)1.49842487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.04938993
2TRIB32.88541963
3PRPF4B2.75268142
4LATS12.72146772
5EPHB12.52094695
6EPHA32.30781990
7PKN22.26644046
8MAP3K102.23184385
9MAP4K12.15662157
10ERN12.08412628
11MAP3K132.04449947
12RIPK12.04141821
13TXK2.01207857
14MAP3K141.97467808
15DMPK1.93219323
16JAK31.90187008
17FGFR31.86625860
18TTN1.84482162
19STK101.79994372
20TAOK31.78909897
21SIK31.76314352
22TYK21.75054355
23JAK11.74717833
24EEF2K1.71078739
25SIK11.70902551
26STK31.70773142
27TBK11.70569557
28CAMK1G1.67855651
29PTK61.66820362
30CDK61.66411066
31CAMK1D1.61236251
32TGFBR21.53886840
33YES11.50347015
34FGFR41.47008068
35NEK91.40109859
36BMX1.37663375
37NUAK11.34714776
38CHUK1.30544280
39IRAK11.26916478
40LRRK21.23042429
41PDGFRB1.19803713
42ZAP701.18485644
43MAP3K31.17656088
44FES1.17634098
45PIK3CG1.17172625
46PDGFRA1.17115147
47CSK1.15479470
48MAP3K21.07542990
49MAP3K11.07156449
50MAPK71.06504852
51HCK1.06092290
52BMPR21.06008734
53BRD41.05592549
54STK41.05212285
55BTK0.99601117
56FGR0.98603690
57JAK20.98114098
58SGK20.96599701
59IKBKB0.95982458
60RPS6KA40.95775450
61TRPM70.95357702
62ITK0.94182115
63MTOR0.93673767
64FGFR20.92270204
65IKBKE0.90513368
66CDC42BPA0.90122732
67ALK0.86592246
68CDK40.86088708
69CSF1R0.84777757
70KSR20.83623235
71MAP3K70.83033539
72IRAK20.80782491
73PAK20.80465806
74PIM10.79748026
75MARK20.77604862
76RIPK40.76607954
77LCK0.75839535
78KIT0.73253424
79SMG10.72671056
80RET0.72448508
81MAP2K30.71106870
82MELK0.70956322
83FRK0.70349024
84MARK30.70298567
85NEK20.66419519
86FGFR10.66090983
87DDR20.65572185
88PDK10.65262809
89CDK90.64073316
90IRAK30.63020558
91STK38L0.62729551
92MAPK120.59949871
93AKT30.59799298
94BLK0.59781837
95HIPK20.59279125
96ABL10.59166899
97STK240.57410964
98ICK0.56718714
99SYK0.56453170
100EGFR0.56332308
101PTK20.56050709
102NLK0.55549682
103PRKCH0.54969311
104IRAK40.54838819
105TNK20.52470493
106TEC0.51474424
107SGK30.50994064
108TGFBR10.49359350
109SIK20.48517419
110MAP3K80.48360915
111PNCK0.47687155
112RPS6KL10.46525329
113RPS6KC10.46525329
114PAK40.46241176
115FLT30.45835726
116PIK3CA0.45378299
117WNK10.44198984
118GRK60.43466533
119GSK3A0.43185298
120PRKD20.43015889
121MATK0.42957200
122PRKCQ0.42952926
123LYN0.42129603
124TYRO30.41352355
125TAOK10.41278334
126MAPKAPK20.41037872
127ERBB40.40274003
128PRKAA20.40022284
129MAPK10.39211078
130PRKD10.38718695

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051402.21485207
2* Osteoclast differentiation_Homo sapiens_hsa043802.09715895
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97813824
4* NF-kappa B signaling pathway_Homo sapiens_hsa040641.93663016
5B cell receptor signaling pathway_Homo sapiens_hsa046621.82692160
6Chronic myeloid leukemia_Homo sapiens_hsa052201.81254056
7Staphylococcus aureus infection_Homo sapiens_hsa051501.75648395
8* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74781379
9* Measles_Homo sapiens_hsa051621.66866309
10* Toxoplasmosis_Homo sapiens_hsa051451.61204484
11Graft-versus-host disease_Homo sapiens_hsa053321.57954548
12Viral myocarditis_Homo sapiens_hsa054161.57373720
13Pancreatic cancer_Homo sapiens_hsa052121.50032794
14Adherens junction_Homo sapiens_hsa045201.49119713
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48669007
16* TNF signaling pathway_Homo sapiens_hsa046681.48153558
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.46269903
18Malaria_Homo sapiens_hsa051441.45786346
19* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41351844
20Small cell lung cancer_Homo sapiens_hsa052221.40773718
21MicroRNAs in cancer_Homo sapiens_hsa052061.38178084
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.38033807
23T cell receptor signaling pathway_Homo sapiens_hsa046601.37529120
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36990974
25Hematopoietic cell lineage_Homo sapiens_hsa046401.36508802
26Acute myeloid leukemia_Homo sapiens_hsa052211.33754872
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33287645
28Primary immunodeficiency_Homo sapiens_hsa053401.32041922
29Legionellosis_Homo sapiens_hsa051341.30887429
30Hepatitis B_Homo sapiens_hsa051611.30845532
31Lysine degradation_Homo sapiens_hsa003101.30289162
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30254480
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28351381
34Proteoglycans in cancer_Homo sapiens_hsa052051.27133472
35Tuberculosis_Homo sapiens_hsa051521.25504583
36Pertussis_Homo sapiens_hsa051331.25212174
37Focal adhesion_Homo sapiens_hsa045101.24196199
38Platelet activation_Homo sapiens_hsa046111.24020368
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23810600
40Amoebiasis_Homo sapiens_hsa051461.21919675
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.20957499
42Influenza A_Homo sapiens_hsa051641.19961379
43* Herpes simplex infection_Homo sapiens_hsa051681.18594192
44Caffeine metabolism_Homo sapiens_hsa002321.15220979
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14788207
46Shigellosis_Homo sapiens_hsa051311.14519867
47Thyroid cancer_Homo sapiens_hsa052161.14174548
48Antigen processing and presentation_Homo sapiens_hsa046121.13121450
49Chemokine signaling pathway_Homo sapiens_hsa040621.12934624
50Dorso-ventral axis formation_Homo sapiens_hsa043201.11910325
51Insulin resistance_Homo sapiens_hsa049311.11604663
52Allograft rejection_Homo sapiens_hsa053301.09115357
53Prostate cancer_Homo sapiens_hsa052151.07894162
54mTOR signaling pathway_Homo sapiens_hsa041501.07255739
55Apoptosis_Homo sapiens_hsa042101.05694303
56Salmonella infection_Homo sapiens_hsa051321.05543816
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04565642
58Prolactin signaling pathway_Homo sapiens_hsa049171.02900659
59Renal cell carcinoma_Homo sapiens_hsa052111.02841736
60Non-small cell lung cancer_Homo sapiens_hsa052230.99985326
61Nitrogen metabolism_Homo sapiens_hsa009100.97741209
62ECM-receptor interaction_Homo sapiens_hsa045120.96993765
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96423161
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.96248988
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96145081
66Hepatitis C_Homo sapiens_hsa051600.93101739
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.92869598
68FoxO signaling pathway_Homo sapiens_hsa040680.92781198
69ErbB signaling pathway_Homo sapiens_hsa040120.92142300
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91637886
71Choline metabolism in cancer_Homo sapiens_hsa052310.91386958
72Notch signaling pathway_Homo sapiens_hsa043300.91199568
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90055528
74Asthma_Homo sapiens_hsa053100.88566177
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.85963230
76Inositol phosphate metabolism_Homo sapiens_hsa005620.85892053
77HTLV-I infection_Homo sapiens_hsa051660.85099326
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.84942758
79Colorectal cancer_Homo sapiens_hsa052100.84767949
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83750426
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.82818472
82TGF-beta signaling pathway_Homo sapiens_hsa043500.82172235
83Circadian rhythm_Homo sapiens_hsa047100.80559474
84Viral carcinogenesis_Homo sapiens_hsa052030.80543886
85Other glycan degradation_Homo sapiens_hsa005110.77937753
86Endometrial cancer_Homo sapiens_hsa052130.75406402
87GnRH signaling pathway_Homo sapiens_hsa049120.75122390
88VEGF signaling pathway_Homo sapiens_hsa043700.73947355
89Insulin signaling pathway_Homo sapiens_hsa049100.72801503
90Glioma_Homo sapiens_hsa052140.71520773
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68764834
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68386174
93Estrogen signaling pathway_Homo sapiens_hsa049150.67701160
94Long-term potentiation_Homo sapiens_hsa047200.67467171
95African trypanosomiasis_Homo sapiens_hsa051430.67208549
96Rheumatoid arthritis_Homo sapiens_hsa053230.67134174
97Type II diabetes mellitus_Homo sapiens_hsa049300.65533514
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63953567
99Pathways in cancer_Homo sapiens_hsa052000.63876650
100Complement and coagulation cascades_Homo sapiens_hsa046100.63537602
101Autoimmune thyroid disease_Homo sapiens_hsa053200.62439199
102HIF-1 signaling pathway_Homo sapiens_hsa040660.61837181
103Lysosome_Homo sapiens_hsa041420.59453145
104Prion diseases_Homo sapiens_hsa050200.57948799
105Bladder cancer_Homo sapiens_hsa052190.57642045
106Type I diabetes mellitus_Homo sapiens_hsa049400.55497970
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54231136
108Dilated cardiomyopathy_Homo sapiens_hsa054140.54017867
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54012238
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51477032
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51382537
112* MAPK signaling pathway_Homo sapiens_hsa040100.50895903
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49978197
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49047346
115Endocytosis_Homo sapiens_hsa041440.48930741
116Rap1 signaling pathway_Homo sapiens_hsa040150.47100362
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.46400214

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »