TAB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of RNA export from nucleus (GO:0046831)6.30743604
2pre-miRNA processing (GO:0031054)5.43873108
3regulation of nucleobase-containing compound transport (GO:0032239)5.38841173
4mitotic sister chromatid cohesion (GO:0007064)5.24644859
5nuclear pore organization (GO:0006999)5.22399288
6nuclear pore complex assembly (GO:0051292)5.18463415
7very-low-density lipoprotein particle assembly (GO:0034379)4.66130992
8cytoplasmic mRNA processing body assembly (GO:0033962)4.62519846
9negative regulation of fibrinolysis (GO:0051918)4.47768593
10mitotic chromosome condensation (GO:0007076)4.32521372
11regulation of centriole replication (GO:0046599)4.23502902
12hemoglobin metabolic process (GO:0020027)4.15179396
13low-density lipoprotein particle clearance (GO:0034383)4.13532740
14plasma lipoprotein particle assembly (GO:0034377)4.13171540
15protoporphyrinogen IX metabolic process (GO:0046501)4.07630145
16regulation of protein activation cascade (GO:2000257)4.06617327
17regulation of fibrinolysis (GO:0051917)3.99098580
18regulation of complement activation (GO:0030449)3.98410012
19monoubiquitinated protein deubiquitination (GO:0035520)3.97929481
20positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.93217826
21positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.93217826
22positive regulation of mitotic sister chromatid separation (GO:1901970)3.93217826
23regulation of protein polyubiquitination (GO:1902914)3.91818884
24negative regulation of histone methylation (GO:0031061)3.89221274
25regulation of meiosis I (GO:0060631)3.86341956
26negative regulation of protein activation cascade (GO:2000258)3.80893747
27protein-lipid complex assembly (GO:0065005)3.80680989
28histone H4-K12 acetylation (GO:0043983)3.72393826
29regulation of sister chromatid cohesion (GO:0007063)3.71354205
30regulation of clathrin-mediated endocytosis (GO:2000369)3.71175452
31protoporphyrinogen IX biosynthetic process (GO:0006782)3.70946559
32glucocorticoid receptor signaling pathway (GO:0042921)3.63203492
33regulation of cholesterol homeostasis (GO:2000188)3.56080606
34cellular response to ethanol (GO:0071361)3.54018844
35androgen biosynthetic process (GO:0006702)3.51905004
36sister chromatid segregation (GO:0000819)3.51122869
37iron ion import (GO:0097286)3.49321997
38protein localization to kinetochore (GO:0034501)3.47987046
39meiotic chromosome segregation (GO:0045132)3.45792209
40corticosteroid receptor signaling pathway (GO:0031958)3.44870104
41embryonic process involved in female pregnancy (GO:0060136)3.44574960
42protein carboxylation (GO:0018214)3.43844239
43peptidyl-glutamic acid carboxylation (GO:0017187)3.43844239
44pore complex assembly (GO:0046931)3.40636489
45negative regulation of complement activation (GO:0045916)3.40472848
46intestinal cholesterol absorption (GO:0030299)3.37350491
47cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.36764481
48plasma lipoprotein particle organization (GO:0071827)3.36709593
49cholesterol efflux (GO:0033344)3.35108987
50gene silencing by RNA (GO:0031047)3.35086931
51chromatin assembly (GO:0031497)3.34422643
52high-density lipoprotein particle remodeling (GO:0034375)3.32135082
53histone H2A monoubiquitination (GO:0035518)3.30012076
54positive regulation of chromosome segregation (GO:0051984)3.29645537
55synaptonemal complex assembly (GO:0007130)3.29184291
56low-density lipoprotein particle remodeling (GO:0034374)3.27263834
57regulation of DNA endoreduplication (GO:0032875)3.26627642
58negative regulation of fatty acid transport (GO:2000192)3.25805018
59protein-lipid complex subunit organization (GO:0071825)3.23621531
60NLS-bearing protein import into nucleus (GO:0006607)3.23206381
61response to follicle-stimulating hormone (GO:0032354)3.22451284
62mitotic sister chromatid segregation (GO:0000070)3.20487481
63positive regulation of hormone biosynthetic process (GO:0046886)3.16657007
64regulation of translational termination (GO:0006449)3.15965880
65heterochromatin organization (GO:0070828)3.15528801
66interleukin-6-mediated signaling pathway (GO:0070102)3.14769355
67sister chromatid cohesion (GO:0007062)3.13571085
68plasma lipoprotein particle remodeling (GO:0034369)3.12731392
69protein-lipid complex remodeling (GO:0034368)3.12731392
70macromolecular complex remodeling (GO:0034367)3.12731392
71nuclear envelope disassembly (GO:0051081)3.12726910
72membrane disassembly (GO:0030397)3.12726910
73detection of molecule of bacterial origin (GO:0032490)3.12704113
74glucocorticoid metabolic process (GO:0008211)3.12278075
75plasma lipoprotein particle clearance (GO:0034381)3.11322453
76attachment of spindle microtubules to kinetochore (GO:0008608)3.10667837
77protein localization to chromosome, centromeric region (GO:0071459)3.09563233
78regulation of histone H3-K9 methylation (GO:0051570)3.07674549
79mitotic nuclear envelope disassembly (GO:0007077)3.05759664
80layer formation in cerebral cortex (GO:0021819)3.03002666
81embryonic retina morphogenesis in camera-type eye (GO:0060059)3.02044152
82protein K48-linked deubiquitination (GO:0071108)3.01969035
83microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.00497219
84reverse cholesterol transport (GO:0043691)3.00325777
85protein localization to chromosome (GO:0034502)2.98514239
86negative regulation of DNA repair (GO:0045738)2.97810526
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97598146
88regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.97302322
89positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.97302322
90germ cell migration (GO:0008354)2.96900682
91histone lysine demethylation (GO:0070076)2.95427754
92regulation of translational fidelity (GO:0006450)2.93910433
93positive regulation of hormone metabolic process (GO:0032352)2.91907390
94histone H3-K9 demethylation (GO:0033169)2.91403350
95peptidyl-lysine dimethylation (GO:0018027)2.91248823
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.87647096
97positive regulation of extracellular matrix organization (GO:1903055)2.86498983
98positive regulation of blood coagulation (GO:0030194)2.85342708
99positive regulation of hemostasis (GO:1900048)2.85342708
100regulation of spindle organization (GO:0090224)2.85081376
101negative regulation of histone modification (GO:0031057)2.84961089
102DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.84253996
103mitotic metaphase plate congression (GO:0007080)2.83697005
104phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.83552339
105regulation of transforming growth factor beta2 production (GO:0032909)2.82719927
106glucocorticoid biosynthetic process (GO:0006704)2.82580916
107regulation of telomere maintenance via telomerase (GO:0032210)2.81525833
108synaptonemal complex organization (GO:0070193)2.80656128
109regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.77996244
110positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.77996244
111DNA unwinding involved in DNA replication (GO:0006268)2.77713891
112blood coagulation, intrinsic pathway (GO:0007597)2.77333555
113spindle assembly involved in mitosis (GO:0090307)2.76769285
114negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.75908780
115definitive hemopoiesis (GO:0060216)2.75272765
116DNA replication-dependent nucleosome organization (GO:0034723)2.74985340
117DNA replication-dependent nucleosome assembly (GO:0006335)2.74985340
118metaphase plate congression (GO:0051310)2.74659753
119histone demethylation (GO:0016577)2.74304316
120hippo signaling (GO:0035329)2.72949751
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.72621225
122peptidyl-lysine trimethylation (GO:0018023)2.72422598
123gene silencing (GO:0016458)2.71517332
124histone H4-K8 acetylation (GO:0043982)2.71038189
125histone H4-K5 acetylation (GO:0043981)2.71038189
126histone H3-K4 trimethylation (GO:0080182)2.70865084
127negative regulation of humoral immune response (GO:0002921)2.70666632
128regulation of apoptotic cell clearance (GO:2000425)2.70570074
129peptidyl-threonine phosphorylation (GO:0018107)2.70346553
130regulation of mitotic spindle organization (GO:0060236)2.70138118
131regulation of gene silencing by RNA (GO:0060966)2.68132719
132regulation of posttranscriptional gene silencing (GO:0060147)2.68132719
133regulation of gene silencing by miRNA (GO:0060964)2.68132719
134histone H3-K36 demethylation (GO:0070544)2.67775339
135interkinetic nuclear migration (GO:0022027)2.66971098
136dosage compensation (GO:0007549)2.66078549
137regulation of centrosome duplication (GO:0010824)2.65574920
138complement activation, alternative pathway (GO:0006957)2.63792282
139negative regulation of chromatin modification (GO:1903309)2.63743163
140regulation of centrosome cycle (GO:0046605)2.63728309
141positive regulation of coagulation (GO:0050820)2.63417630
142macroautophagy (GO:0016236)2.59502405
143histone H3-K4 methylation (GO:0051568)2.58146551
144amyloid precursor protein catabolic process (GO:0042987)2.55303130
145positive regulation of male gonad development (GO:2000020)2.54056780
146protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.53951657
147peptidyl-threonine modification (GO:0018210)2.53808681
148histone H4-K16 acetylation (GO:0043984)2.53791412
149histone lysine methylation (GO:0034968)2.53479946
150RNA stabilization (GO:0043489)2.52897874
151mRNA stabilization (GO:0048255)2.52897874
152DNA duplex unwinding (GO:0032508)2.50811951
153regulation of DNA damage checkpoint (GO:2000001)2.50411447
154DNA geometric change (GO:0032392)2.50340259
155protein dealkylation (GO:0008214)2.50017086
156regulation of transforming growth factor beta production (GO:0071634)2.47792249
157regulation of humoral immune response (GO:0002920)2.47677618
158regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46114535
159cholesterol transport (GO:0030301)2.43476464
160sterol transport (GO:0015918)2.43476464
161dicarboxylic acid biosynthetic process (GO:0043650)2.40959853
162lipoprotein metabolic process (GO:0042157)2.39240818
163regulation of histone H3-K27 methylation (GO:0061085)2.38078140
164intestinal absorption (GO:0050892)2.36408949
165desmosome organization (GO:0002934)2.34834082
166acylglycerol homeostasis (GO:0055090)2.34182344
167triglyceride homeostasis (GO:0070328)2.34182344
168positive regulation of glycolytic process (GO:0045821)2.33909150
169positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32796288
170cellular response to growth hormone stimulus (GO:0071378)2.32503586
171COPII vesicle coating (GO:0048208)2.31918960
172regulation of cholesterol storage (GO:0010885)2.31490987
173regulation of bile acid biosynthetic process (GO:0070857)2.31331501
174hypotonic response (GO:0006971)2.30875828
175negative regulation of lipid transport (GO:0032369)2.29461013
176acute-phase response (GO:0006953)2.28507379
177androgen metabolic process (GO:0008209)2.27323472
178response to interleukin-15 (GO:0070672)2.26901076
179positive regulation vascular endothelial growth factor production (GO:0010575)2.25863292
180progesterone metabolic process (GO:0042448)2.25560417
181fibrinolysis (GO:0042730)2.25483360
182cholesterol homeostasis (GO:0042632)2.25336084
183sterol homeostasis (GO:0055092)2.23761866
184positive regulation of lipid storage (GO:0010884)2.23177259
185negative regulation of sterol transport (GO:0032372)2.23012165
186negative regulation of cholesterol transport (GO:0032375)2.23012165
187positive regulation of transforming growth factor beta production (GO:0071636)2.20408164
188negative regulation of erythrocyte differentiation (GO:0045647)2.19010048
189positive regulation of lipid catabolic process (GO:0050996)2.18753191
190lipid homeostasis (GO:0055088)2.18327775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93542058
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.78696306
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.78176146
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.77207744
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.45232891
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.42280977
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25159686
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73969960
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.73879641
10SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.68534141
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.60276898
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.58745150
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.52524626
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.46272067
15GATA1_22025678_ChIP-Seq_K562_Human2.40469821
16ZNF263_19887448_ChIP-Seq_K562_Human2.39155621
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.34953798
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23238607
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.22119434
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17238924
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05965549
22ESR1_15608294_ChIP-ChIP_MCF-7_Human2.05802609
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04423430
24AR_21909140_ChIP-Seq_LNCAP_Human2.01853142
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99767911
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98492416
27FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.97351915
28MYC_22102868_ChIP-Seq_BL_Human1.94905171
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94474349
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.93161941
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.90372770
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.89418604
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86324674
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84380311
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78252841
36* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72946426
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72446024
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72031800
39AR_21572438_ChIP-Seq_LNCaP_Human1.69302340
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68708377
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.65856875
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65181366
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64934699
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63507416
45RUNX_20019798_ChIP-Seq_JUKART_Human1.61450745
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59864164
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59100122
48AHR_22903824_ChIP-Seq_MCF-7_Human1.55845377
49SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54191596
50SCL_19346495_ChIP-Seq_HPC-7_Human1.52786462
51TCF7_22412390_ChIP-Seq_EML_Mouse1.52635182
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51542683
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.50643375
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49581462
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48061960
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47851351
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.47258113
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45928191
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45693651
60CHD1_26751641_Chip-Seq_LNCaP_Human1.44819044
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.42560421
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41998801
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41097079
64VDR_24787735_ChIP-Seq_THP-1_Human1.39609643
65HNF4A_19822575_ChIP-Seq_HepG2_Human1.39379055
66KDM2B_26808549_Chip-Seq_DND41_Human1.38582351
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36780178
68GATA1_19941826_ChIP-Seq_K562_Human1.36523171
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.34835340
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34520864
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34220398
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33667206
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33652531
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33502482
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.32003232
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31767712
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30884846
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30436090
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30309555
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30065514
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.29970943
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29227872
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27735338
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27729728
85KDM2B_26808549_Chip-Seq_K562_Human1.26905187
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.26766177
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25969133
88FUS_26573619_Chip-Seq_HEK293_Human1.25740861
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25651110
90CLOCK_20551151_ChIP-Seq_293T_Human1.24953504
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24536054
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21674678
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19631507
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19029708
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17177158
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15627663
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15336261
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14892392
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14246755
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.14198342
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14088606
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13182859
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.12680363
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12556143
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11520921
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11461933
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11444274
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11170009
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10945866
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10844564
111ATF3_27146783_Chip-Seq_COLON_Human1.10082841
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.09180805
113TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09115454
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08693020
115FOXA1_25552417_ChIP-Seq_VCAP_Human1.07872156
116GATA4_25053715_ChIP-Seq_YYC3_Human1.07545898
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.07269229
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.06738814
119TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06527066
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06363455
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06300771
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05991216
123PIAS1_25552417_ChIP-Seq_VCAP_Human1.05891361
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05474409
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04199201
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02514838
127* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02486668
128SPI1_23127762_ChIP-Seq_K562_Human1.01997509
129GATA6_25053715_ChIP-Seq_YYC3_Human1.00933613
130TP63_17297297_ChIP-ChIP_HaCaT_Human1.00467326
131NCOR1_26117541_ChIP-Seq_K562_Human1.00098836
132NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00077766
133ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99891827
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.98640519
135TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98229291
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98194783
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96468618
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95993472
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95739759
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95718582
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95718582
142* TP63_23658742_ChIP-Seq_EP156T_Human0.95504603
143PU_27001747_Chip-Seq_BMDM_Mouse0.93677865
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93510262
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92867236
146TP53_16413492_ChIP-PET_HCT116_Human0.92596787
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92225014
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90315630
149KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90137510
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.89709743
151MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89292637
152BRD4_25478319_ChIP-Seq_HGPS_Human0.89271083
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89233606
154GATA2_19941826_ChIP-Seq_K562_Human0.88940548
155* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88608765
156KDM5A_27292631_Chip-Seq_BREAST_Human0.87817439
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87740876
158NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87690550
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87658411
160SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86804591
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86373148
162NANOG_16518401_ChIP-PET_MESCs_Mouse0.86354413
163NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86131392
164RUNX1_27514584_Chip-Seq_MCF-7_Human0.85860899
165PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85313596
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84957305
167EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84419535
168SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84314587
169SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84314587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH4.13349981
2MP0003123_paternal_imprinting3.54162246
3MP0005076_abnormal_cell_differentiation3.40850461
4MP0002139_abnormal_hepatobiliary_system3.30076492
5MP0010352_gastrointestinal_tract_polyps3.19487215
6MP0003890_abnormal_embryonic-extraembry3.15662701
7MP0003195_calcinosis3.11971708
8MP0000569_abnormal_digit_pigmentation3.08647281
9MP0008877_abnormal_DNA_methylation3.04765634
10MP0010307_abnormal_tumor_latency2.87676777
11MP0005365_abnormal_bile_salt2.83593208
12MP0005451_abnormal_body_composition2.79292347
13MP0003111_abnormal_nucleus_morphology2.77310627
14MP0010329_abnormal_lipoprotein_level2.65945144
15MP0010234_abnormal_vibrissa_follicle2.62041387
16MP0003656_abnormal_erythrocyte_physiolo2.59278056
17MP0010094_abnormal_chromosome_stability2.54326152
18MP0005409_darkened_coat_color2.47436075
19MP0003787_abnormal_imprinting2.39710901
20MP0003121_genomic_imprinting2.37822832
21MP0003172_abnormal_lysosome_physiology2.34147777
22MP0003693_abnormal_embryo_hatching2.32189980
23MP0008057_abnormal_DNA_replication2.31238470
24MP0002877_abnormal_melanocyte_morpholog2.26534967
25MP0003077_abnormal_cell_cycle2.25063746
26MP0003705_abnormal_hypodermis_morpholog2.22905615
27MP0005085_abnormal_gallbladder_physiolo2.20827145
28MP0001730_embryonic_growth_arrest2.18931355
29MP0002084_abnormal_developmental_patter2.05993422
30MP0003122_maternal_imprinting2.05797353
31MP0004957_abnormal_blastocyst_morpholog2.03892339
32MP0004147_increased_porphyrin_level2.02833738
33MP0004197_abnormal_fetal_growth/weight/1.95628298
34MP0001672_abnormal_embryogenesis/_devel1.95204862
35MP0005380_embryogenesis_phenotype1.95204862
36MP0000350_abnormal_cell_proliferation1.94369926
37MP0003252_abnormal_bile_duct1.92889114
38MP0005464_abnormal_platelet_physiology1.91520698
39MP0002086_abnormal_extraembryonic_tissu1.91482837
40MP0003724_increased_susceptibility_to1.90668894
41MP0001666_abnormal_nutrient_absorption1.90057442
42MP0003984_embryonic_growth_retardation1.88817962
43MP0002088_abnormal_embryonic_growth/wei1.88031456
44MP0008875_abnormal_xenobiotic_pharmacok1.77441218
45MP0005187_abnormal_penis_morphology1.77439230
46MP0003183_abnormal_peptide_metabolism1.77159030
47MP0001697_abnormal_embryo_size1.74545178
48MP0003868_abnormal_feces_composition1.71925980
49MP0004185_abnormal_adipocyte_glucose1.67341288
50MP0000609_abnormal_liver_physiology1.65579736
51MP0003303_peritoneal_inflammation1.65131367
52MP0004859_abnormal_synaptic_plasticity1.62710379
53MP0002138_abnormal_hepatobiliary_system1.56940296
54MP0005623_abnormal_meninges_morphology1.54568935
55MP0004808_abnormal_hematopoietic_stem1.52148311
56MP0004264_abnormal_extraembryonic_tissu1.51727095
57MP0004270_analgesia1.49804771
58MP0005058_abnormal_lysosome_morphology1.49457419
59MP0006292_abnormal_olfactory_placode1.48317027
60MP0002085_abnormal_embryonic_tissue1.47500524
61MP0003436_decreased_susceptibility_to1.46705831
62MP0001661_extended_life_span1.45094527
63MP0003045_fibrosis1.41998279
64MP0009703_decreased_birth_body1.41113357
65MP0002118_abnormal_lipid_homeostasis1.39374955
66MP0001849_ear_inflammation1.37725776
67MP0002009_preneoplasia1.37087310
68MP0001851_eye_inflammation1.36084532
69MP0010678_abnormal_skin_adnexa1.34476921
70MP0004883_abnormal_blood_vessel1.31863667
71MP0002080_prenatal_lethality1.28976048
72MP0002653_abnormal_ependyma_morphology1.28865141
73MP0000685_abnormal_immune_system1.27078879
74MP0000516_abnormal_urinary_system1.26235330
75MP0005367_renal/urinary_system_phenotyp1.26235330
76MP0000639_abnormal_adrenal_gland1.25983931
77MP0000537_abnormal_urethra_morphology1.25587551
78MP0005164_abnormal_response_to1.25258964
79MP0003119_abnormal_digestive_system1.25199848
80MP0004947_skin_inflammation1.23994662
81MP0008058_abnormal_DNA_repair1.23250465
82MP0005408_hypopigmentation1.21933749
83MP0003221_abnormal_cardiomyocyte_apopto1.21727972
84MP0009672_abnormal_birth_weight1.20812518
85MP0005248_abnormal_Harderian_gland1.20442150
86MP0002909_abnormal_adrenal_gland1.17856224
87MP0001873_stomach_inflammation1.15780694
88MP0009053_abnormal_anal_canal1.13395540
89MP0000371_diluted_coat_color1.13240369
90MP0005334_abnormal_fat_pad1.13210110
91MP0003300_gastrointestinal_ulcer1.11418009
92MP0010368_abnormal_lymphatic_system1.10747759
93MP0002210_abnormal_sex_determination1.09338571
94MP0002089_abnormal_postnatal_growth/wei1.08930976
95MP0003861_abnormal_nervous_system1.08007147
96MP0008770_decreased_survivor_rate1.07294288
97MP0008961_abnormal_basal_metabolism1.07218887
98MP0009840_abnormal_foam_cell1.05089669
99MP0005360_urolithiasis1.04488009
100MP0009780_abnormal_chondrocyte_physiolo1.04393384
101MP0003453_abnormal_keratinocyte_physiol1.04356571
102MP0000383_abnormal_hair_follicle1.04228494
103MP0003828_pulmonary_edema1.03842854
104MP0009115_abnormal_fat_cell1.03634835
105MP0001145_abnormal_male_reproductive1.03224805
106MP0002925_abnormal_cardiovascular_devel1.01793778
107MP0008995_early_reproductive_senescence1.01600218
108MP0003763_abnormal_thymus_physiology1.01506812
109MP0003567_abnormal_fetal_cardiomyocyte0.99047692
110MP0002132_abnormal_respiratory_system0.98572399
111MP0001293_anophthalmia0.96760010
112MP0000598_abnormal_liver_morphology0.96534367
113MP0005083_abnormal_biliary_tract0.95614447
114MP0005666_abnormal_adipose_tissue0.95536365
115MP0000653_abnormal_sex_gland0.92530321
116MP0002998_abnormal_bone_remodeling0.92051166
117MP0008007_abnormal_cellular_replicative0.88788655
118MP0005397_hematopoietic_system_phenotyp0.87994829
119MP0001545_abnormal_hematopoietic_system0.87994829
120MP0003935_abnormal_craniofacial_develop0.87589465
121MP0002168_other_aberrant_phenotype0.87430378
122MP0000427_abnormal_hair_cycle0.87002155
123MP0005310_abnormal_salivary_gland0.85685000
124MP0003566_abnormal_cell_adhesion0.85500502
125MP0005621_abnormal_cell_physiology0.85379685
126MP0002971_abnormal_brown_adipose0.84034435
127MP0001929_abnormal_gametogenesis0.83716386
128MP0010155_abnormal_intestine_physiology0.81926324
129MP0003937_abnormal_limbs/digits/tail_de0.81896021
130MP0004233_abnormal_muscle_weight0.80329204
131MP0000432_abnormal_head_morphology0.80110214
132MP0004130_abnormal_muscle_cell0.80017199
133MP0000266_abnormal_heart_morphology0.79790952
134MP0006072_abnormal_retinal_apoptosis0.79627611
135MP0001784_abnormal_fluid_regulation0.79280576
136MP0004381_abnormal_hair_follicle0.78772234
137MP0005647_abnormal_sex_gland0.78219016
138MP0003950_abnormal_plasma_membrane0.78043869
139MP0002254_reproductive_system_inflammat0.77268309
140MP0002896_abnormal_bone_mineralization0.76763564
141MP0010630_abnormal_cardiac_muscle0.76715153
142MP0008932_abnormal_embryonic_tissue0.76665596
143MP0002332_abnormal_exercise_endurance0.75966878
144MP0003936_abnormal_reproductive_system0.75471179
145MP0000627_abnormal_mammary_gland0.75194213
146MP0003091_abnormal_cell_migration0.74986373
147MP0001915_intracranial_hemorrhage0.74818454
148MP0005448_abnormal_energy_balance0.74355359
149MP0005319_abnormal_enzyme/_coenzyme0.74336281
150MP0002078_abnormal_glucose_homeostasis0.73892085
151MP0002166_altered_tumor_susceptibility0.73760362
152MP0000566_synostosis0.73595814
153MP0002419_abnormal_innate_immunity0.73529864
154MP0002006_tumorigenesis0.72787429
155MP0003755_abnormal_palate_morphology0.72371480
156MP0005384_cellular_phenotype0.72128390
157MP0000490_abnormal_crypts_of0.71990004
158MP0002933_joint_inflammation0.71160962
159MP0000579_abnormal_nail_morphology0.70776571
160MP0003632_abnormal_nervous_system0.70588417
161MP0000313_abnormal_cell_death0.70580151
162MP0002405_respiratory_system_inflammati0.69914577
163MP0003943_abnormal_hepatobiliary_system0.69882418
164MP0003953_abnormal_hormone_level0.69698881
165MP0004885_abnormal_endolymph0.69254028
166MP0000778_abnormal_nervous_system0.69247121
167MP0005636_abnormal_mineral_homeostasis0.68746096
168MP0000428_abnormal_craniofacial_morphol0.68556478
169MP0002697_abnormal_eye_size0.68383876
170MP0001800_abnormal_humoral_immune0.67766519
171MP0004811_abnormal_neuron_physiology0.67615827
172MP0009642_abnormal_blood_homeostasis0.67173759

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.44267523
2Abnormality of the common coagulation pathway (HP:0010990)4.30943010
3Prolonged partial thromboplastin time (HP:0003645)4.20726515
4Hypochromic microcytic anemia (HP:0004840)4.18649495
5Volvulus (HP:0002580)4.17528277
6Poikilocytosis (HP:0004447)3.70737883
7Heterotopia (HP:0002282)3.43963357
8Hypobetalipoproteinemia (HP:0003563)3.34134886
9Papillary thyroid carcinoma (HP:0002895)3.33295899
10Gingival bleeding (HP:0000225)3.28503676
11Abnormality of the nasal septum (HP:0000419)3.24093344
12Joint hemorrhage (HP:0005261)3.21256610
13Abnormality of the lower motor neuron (HP:0002366)3.19757406
14Menorrhagia (HP:0000132)3.06729467
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.03086866
16Complement deficiency (HP:0004431)3.02918564
17Macroorchidism (HP:0000053)3.01775855
18Abnormality of the fingertips (HP:0001211)3.01744896
19Diastasis recti (HP:0001540)2.90653637
20Epiphyseal dysplasia (HP:0002656)2.84373169
21Abnormality of the astrocytes (HP:0100707)2.79495270
22Astrocytoma (HP:0009592)2.79495270
23Acanthocytosis (HP:0001927)2.75215835
24Prominent nose (HP:0000448)2.74926478
25Osteomalacia (HP:0002749)2.73692858
26Asymmetry of the thorax (HP:0001555)2.70657749
27Prolonged bleeding time (HP:0003010)2.64462940
28Abnormality of the labia minora (HP:0012880)2.63353182
29Facial hemangioma (HP:0000329)2.59778594
30Testicular neoplasm (HP:0010788)2.54730399
31Ependymoma (HP:0002888)2.54066063
32Vitreoretinal degeneration (HP:0000655)2.54044170
33Abnormality of carpal bone ossification (HP:0006257)2.53767875
34Spontaneous abortion (HP:0005268)2.52812531
35Termporal pattern (HP:0011008)2.51664267
36Insidious onset (HP:0003587)2.51664267
37Hypoplastic ischia (HP:0003175)2.49332613
38Glomerulonephritis (HP:0000099)2.47385526
39Amyotrophic lateral sclerosis (HP:0007354)2.45024872
40Mitral stenosis (HP:0001718)2.43977661
41Gastrointestinal infarctions (HP:0005244)2.42216917
42Arthropathy (HP:0003040)2.36312240
43Cortical dysplasia (HP:0002539)2.33268490
44Ankyloglossia (HP:0010296)2.32377086
45Large earlobe (HP:0009748)2.32256541
46Truncal obesity (HP:0001956)2.32209123
47Subacute progressive viral hepatitis (HP:0006572)2.31597583
48Sandal gap (HP:0001852)2.31417280
49Hypercholesterolemia (HP:0003124)2.31049475
50Tapered finger (HP:0001182)2.30265083
51Abnormality of the ischium (HP:0003174)2.28235844
52Fair hair (HP:0002286)2.27923601
53Abnormality of the alveolar ridges (HP:0006477)2.26385702
54Broad alveolar ridges (HP:0000187)2.26289836
55Insomnia (HP:0100785)2.25736790
56Irregular epiphyses (HP:0010582)2.24723583
57High pitched voice (HP:0001620)2.21592117
58Abnormal hand bone ossification (HP:0010660)2.21222299
59Inappropriate behavior (HP:0000719)2.21073687
60Coarse hair (HP:0002208)2.20821743
61Right ventricular cardiomyopathy (HP:0011663)2.19969598
62Xanthomatosis (HP:0000991)2.19686363
63Vertebral arch anomaly (HP:0008438)2.18184167
64Abnormality of the lumbar spine (HP:0100712)2.17193070
65Epidermoid cyst (HP:0200040)2.16236881
66Gonadal dysgenesis (HP:0000133)2.16132996
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15795174
68Broad thumb (HP:0011304)2.15751887
69Abnormal ossification of hand bones (HP:0005921)2.15020646
70Thyroid carcinoma (HP:0002890)2.13426626
71Abnormality of complement system (HP:0005339)2.12207149
72Epistaxis (HP:0000421)2.10195393
73Hemorrhage of the eye (HP:0011885)2.09722321
74Dysmetric saccades (HP:0000641)2.08665291
75Deviation of the thumb (HP:0009603)2.08401497
76Abnormality of the wing of the ilium (HP:0011867)2.07448717
77Submucous cleft hard palate (HP:0000176)2.06602623
78Oligodactyly (HP:0012165)2.05294837
79Obsessive-compulsive behavior (HP:0000722)2.03618657
80Joint swelling (HP:0001386)2.03566498
81Recurrent gram-negative bacterial infections (HP:0005420)2.03315595
82Transitional cell carcinoma of the bladder (HP:0006740)2.01441920
83Sacral dimple (HP:0000960)2.01405945
84Sex reversal (HP:0012245)2.01189887
85Abnormal sex determination (HP:0012244)2.01189887
86Urinary glycosaminoglycan excretion (HP:0003541)2.00019300
87Mucopolysacchariduria (HP:0008155)2.00019300
88Hypoplasia of dental enamel (HP:0006297)1.98706307
89Proximal placement of thumb (HP:0009623)1.98537795
90Abnormal tarsal ossification (HP:0008369)1.98233881
91Peritonitis (HP:0002586)1.97644746
92Glioma (HP:0009733)1.97331357
93Neoplasm of the oral cavity (HP:0100649)1.96947854
94Relative macrocephaly (HP:0004482)1.96701159
95Abnormal foot bone ossification (HP:0010675)1.96667102
96Abnormality of ocular smooth pursuit (HP:0000617)1.96405093
97Limited elbow extension (HP:0001377)1.96096400
98Shawl scrotum (HP:0000049)1.94953478
99Oligodactyly (hands) (HP:0001180)1.94623676
100Visual hallucinations (HP:0002367)1.94481792
101Hand muscle atrophy (HP:0009130)1.93986976
102Urinary bladder sphincter dysfunction (HP:0002839)1.93900715
103Small epiphyses (HP:0010585)1.93014686
104Aqueductal stenosis (HP:0002410)1.92609350
105Anal stenosis (HP:0002025)1.91860769
106Hypolipoproteinemia (HP:0010981)1.91728552
107Abnormality of the corticospinal tract (HP:0002492)1.91293316
108Urinary urgency (HP:0000012)1.91087229
109Mild short stature (HP:0003502)1.90410491
110Acute hepatic failure (HP:0006554)1.89836604
111Bladder carcinoma (HP:0002862)1.89632955
112Bladder neoplasm (HP:0009725)1.89632955
113Abnormality of chromosome segregation (HP:0002916)1.89324307
114Menstrual irregularities (HP:0000858)1.89084130
115Generalized hypopigmentation of hair (HP:0011358)1.88487389
116Increased nuchal translucency (HP:0010880)1.87497894
117Thrombophlebitis (HP:0004418)1.86757411
118Skin nodule (HP:0200036)1.86431908
119Biliary tract neoplasm (HP:0100574)1.85916461
120Reticulocytosis (HP:0001923)1.85907558
121Carpal bone hypoplasia (HP:0001498)1.85725467
122Metaphyseal cupping (HP:0003021)1.85190305
123Resting tremor (HP:0002322)1.84921811
124Colon cancer (HP:0003003)1.84068374
125Cafe-au-lait spot (HP:0000957)1.83824899
126Cystic hygroma (HP:0000476)1.83711844
127Thickened calvaria (HP:0002684)1.83371818
128Gastrointestinal carcinoma (HP:0002672)1.83354072
129Malignant gastrointestinal tract tumors (HP:0006749)1.83354072
130Genetic anticipation (HP:0003743)1.82570783
131Polycythemia (HP:0001901)1.81908413
132Dislocated radial head (HP:0003083)1.81872697
133Broad palm (HP:0001169)1.81227848
134Urethral obstruction (HP:0000796)1.81117624
135Conjugated hyperbilirubinemia (HP:0002908)1.80413747
136Abnormality of polysaccharide metabolism (HP:0011012)1.80227781
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80227781
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80227781
139Blue irides (HP:0000635)1.80012910
140Excessive salivation (HP:0003781)1.78762914
141Drooling (HP:0002307)1.78762914
142Curly hair (HP:0002212)1.78707789
143Abnormality of chromosome stability (HP:0003220)1.78468916
144Medulloblastoma (HP:0002885)1.77195840
145Myocardial infarction (HP:0001658)1.76735723
146Hepatoblastoma (HP:0002884)1.75385357
147Neoplasm of the adrenal cortex (HP:0100641)1.74719093
148Flat acetabular roof (HP:0003180)1.74707722
149Narrow palate (HP:0000189)1.74425270
150Attention deficit hyperactivity disorder (HP:0007018)1.74204633
151Basal cell carcinoma (HP:0002671)1.73482669
152Hypophosphatemic rickets (HP:0004912)1.73303641
153Complete atrioventricular canal defect (HP:0001674)1.72273365
154Cupped ear (HP:0000378)1.71813235
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71354450
156Short 1st metacarpal (HP:0010034)1.71354450
157Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70909472
158Exostoses (HP:0100777)1.70843960
159Abnormality of the radial head (HP:0003995)1.68933809
160Arterial thrombosis (HP:0004420)1.68911993
161Vertebral clefting (HP:0008428)1.68628196
162Abnormality of oral frenula (HP:0000190)1.68022230
163Rickets (HP:0002748)1.67815206
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67421791
165Absent frontal sinuses (HP:0002688)1.67265275
166Rhizomelia (HP:0008905)1.66565591
167Impaired smooth pursuit (HP:0007772)1.66557782
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66124029
169Anomalous pulmonary venous return (HP:0010772)1.65116284
170Disinhibition (HP:0000734)1.64860991
171Short 4th metacarpal (HP:0010044)1.64533121
172Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64533121
173Retrobulbar optic neuritis (HP:0100654)1.63437172
174Optic neuritis (HP:0100653)1.63437172
17511 pairs of ribs (HP:0000878)1.63021373
176Nephritis (HP:0000123)1.62117359
177Hepatocellular carcinoma (HP:0001402)1.62110899
178Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61984266
179Rhabdomyosarcoma (HP:0002859)1.60876611
180Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60274844
181Pelvic girdle muscle weakness (HP:0003749)1.58707913
182Global brain atrophy (HP:0002283)1.57520568
183Chromsome breakage (HP:0040012)1.56936205
184Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.55427518
185Abnormality of the musculature of the pelvis (HP:0001469)1.54893300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.38832161
2PRPF4B3.08281353
3CDC73.05180997
4LATS13.03432254
5LATS22.71656753
6PKN22.49186571
7MAP3K92.48837415
8STK32.45731989
9SCYL22.34660756
10BRD42.19176462
11MAP3K42.05769357
12TYRO32.01758992
13PLK41.78135085
14CAMK1D1.71267474
15EEF2K1.65030511
16TRIB31.63626691
17RET1.60482207
18KSR21.59817630
19CDK61.56667510
20FGFR21.56578779
21ACVR1B1.54156982
22JAK11.53038274
23MARK11.52060444
24STK101.51230913
25STK241.46605612
26NEK21.43581833
27MAP3K21.41147819
28FRK1.38611274
29NLK1.34742684
30TRPM71.32295168
31MAP3K141.30814310
32MAP3K71.29915882
33PLK21.29780087
34MAP2K31.27800131
35NTRK31.26665163
36CDK91.23526408
37TTK1.20744971
38NEK11.20613689
39MTOR1.20014816
40SGK4941.19927917
41SGK2231.19927917
42PDGFRA1.19340262
43FGFR31.16518620
44TAOK31.15795315
45CAMK1G1.15682432
46PRKAA21.12057458
47MELK1.10848484
48MAP2K41.10608907
49YES11.07524497
50CHEK11.03732123
51RIPK11.02804557
52SIK21.02708198
53CDK41.00732588
54ZAP701.00520132
55MAP3K10.98232335
56PIK3CA0.97911140
57ALK0.97280721
58KSR10.96797484
59FGFR10.96325014
60RPS6KB20.96119294
61ICK0.95815228
62CHEK20.94886814
63JAK20.90359097
64MAP3K80.90234738
65PDGFRB0.89918757
66TAOK20.89463839
67CDC42BPA0.89458515
68MARK20.88185368
69AKT30.88161625
70NEK90.88077361
71NTRK20.87664074
72IRAK10.87442809
73HIPK20.86685153
74EPHA30.86059233
75MARK30.84532751
76AURKB0.83877116
77EPHB10.83578376
78TYK20.82360004
79CAMKK20.81549141
80BRSK20.81444261
81PLK10.80560522
82ATM0.78402943
83PDPK10.78108764
84FGR0.78031428
85MAP3K130.77981468
86PLK30.77492770
87SGK30.77471243
88PRKD30.77028076
89STK380.76647819
90CAMK40.75288640
91ERBB20.72431151
92IKBKE0.72235716
93CDK20.71523841
94MATK0.70756232
95MAP3K60.69984850
96ERN10.69233726
97DAPK20.68827150
98TGFBR10.68479699
99CHUK0.68267419
100MAP3K100.67845737
101SIK10.66984693
102CSNK1D0.66774859
103DMPK0.66704140
104TAOK10.65593966
105RIPK40.65086343
106STK40.64684992
107EIF2AK10.64462456
108MAPK110.63127371
109PRKAA10.62813589
110STK38L0.62764539
111TGFBR20.60324650
112MAP3K30.59201241
113ATR0.58287850
114CDK10.57970813
115MAPK100.57481500
116BLK0.57335373
117PAK60.57205515
118SGK20.56665073
119CSNK1G20.55754338
120WEE10.55700743
121CSK0.53368626
122MINK10.53139603
123MAP3K50.51928387
124FGFR40.51830259
125WNK10.51776547
126MAP2K70.50711123
127STK110.49118958
128JAK30.48941503
129MAPK140.48724888
130BMPR20.48175158
131SYK0.47475276
132TXK0.47185915
133TIE10.46756894
134GRK60.45148552
135BRSK10.44083666
136SGK10.42520441
137DYRK1B0.42392760
138PTK20.42269526
139CDK70.41429806
140IRAK40.41351823
141WNK40.41329136
142GSK3B0.41186137
143PNCK0.40892082
144MAPK30.40152518
145BTK0.39922063
146DDR20.39529926
147PTK60.39086313
148GRK50.39077414
149PRKDC0.38909861
150CSNK1E0.38890912
151AKT10.33438745
152PDK10.32958702
153RPS6KB10.31824307

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.02283665
2Dorso-ventral axis formation_Homo sapiens_hsa043202.35652392
3mTOR signaling pathway_Homo sapiens_hsa041502.17103866
4Cell cycle_Homo sapiens_hsa041102.11105562
5Steroid biosynthesis_Homo sapiens_hsa001001.93994386
6Oocyte meiosis_Homo sapiens_hsa041141.86924742
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.85572281
8Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.84297261
9mRNA surveillance pathway_Homo sapiens_hsa030151.74548764
10Long-term potentiation_Homo sapiens_hsa047201.64230813
11Fatty acid biosynthesis_Homo sapiens_hsa000611.62090694
12RNA transport_Homo sapiens_hsa030131.59753906
13Endometrial cancer_Homo sapiens_hsa052131.51917406
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.51859479
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47205703
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.46902142
17Lysine degradation_Homo sapiens_hsa003101.46663809
18Colorectal cancer_Homo sapiens_hsa052101.46063482
19Non-small cell lung cancer_Homo sapiens_hsa052231.45398369
20Glioma_Homo sapiens_hsa052141.44703350
21MicroRNAs in cancer_Homo sapiens_hsa052061.44322327
22ABC transporters_Homo sapiens_hsa020101.44222670
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41482569
24Adherens junction_Homo sapiens_hsa045201.39071898
25Insulin resistance_Homo sapiens_hsa049311.37658135
26ErbB signaling pathway_Homo sapiens_hsa040121.36475230
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35662065
28Chronic myeloid leukemia_Homo sapiens_hsa052201.34333345
29Ovarian steroidogenesis_Homo sapiens_hsa049131.33189762
30Thyroid cancer_Homo sapiens_hsa052161.29987472
31Systemic lupus erythematosus_Homo sapiens_hsa053221.29329342
32Viral carcinogenesis_Homo sapiens_hsa052031.29067429
33Hippo signaling pathway_Homo sapiens_hsa043901.27806688
34Staphylococcus aureus infection_Homo sapiens_hsa051501.26436538
35Circadian rhythm_Homo sapiens_hsa047101.26229152
36Small cell lung cancer_Homo sapiens_hsa052221.25776148
37B cell receptor signaling pathway_Homo sapiens_hsa046621.25276300
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23483608
39Pancreatic cancer_Homo sapiens_hsa052121.23177488
40Type II diabetes mellitus_Homo sapiens_hsa049301.22635378
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21610943
42FoxO signaling pathway_Homo sapiens_hsa040681.19569088
43TGF-beta signaling pathway_Homo sapiens_hsa043501.18700829
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.18518873
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17361883
46VEGF signaling pathway_Homo sapiens_hsa043701.17328372
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.13264902
48Choline metabolism in cancer_Homo sapiens_hsa052311.12908336
49Alcoholism_Homo sapiens_hsa050341.11908262
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10693884
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07028200
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06169002
53Insulin signaling pathway_Homo sapiens_hsa049101.05296053
54GnRH signaling pathway_Homo sapiens_hsa049121.04690057
55Hepatitis C_Homo sapiens_hsa051601.00995969
56Other glycan degradation_Homo sapiens_hsa005110.99971653
57Renal cell carcinoma_Homo sapiens_hsa052110.98730127
58Bile secretion_Homo sapiens_hsa049760.98479804
59p53 signaling pathway_Homo sapiens_hsa041150.98332237
60Bladder cancer_Homo sapiens_hsa052190.96163600
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.96154342
62Nitrogen metabolism_Homo sapiens_hsa009100.96000829
63Prostate cancer_Homo sapiens_hsa052150.95586023
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.95305663
65One carbon pool by folate_Homo sapiens_hsa006700.94710515
66Osteoclast differentiation_Homo sapiens_hsa043800.93924972
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93020441
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92688166
69Proteoglycans in cancer_Homo sapiens_hsa052050.92365126
70AMPK signaling pathway_Homo sapiens_hsa041520.92203151
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91821528
72Vitamin digestion and absorption_Homo sapiens_hsa049770.91587278
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91143080
74Wnt signaling pathway_Homo sapiens_hsa043100.90947408
75Inositol phosphate metabolism_Homo sapiens_hsa005620.90891139
76Prolactin signaling pathway_Homo sapiens_hsa049170.89710055
77Estrogen signaling pathway_Homo sapiens_hsa049150.89409148
78PPAR signaling pathway_Homo sapiens_hsa033200.88990317
79* TNF signaling pathway_Homo sapiens_hsa046680.87096151
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87072827
81HTLV-I infection_Homo sapiens_hsa051660.86911874
82Hepatitis B_Homo sapiens_hsa051610.86275824
83Histidine metabolism_Homo sapiens_hsa003400.85562164
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.84827200
85Dopaminergic synapse_Homo sapiens_hsa047280.83289464
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82955942
87Fat digestion and absorption_Homo sapiens_hsa049750.82156085
88Long-term depression_Homo sapiens_hsa047300.80906692
89Starch and sucrose metabolism_Homo sapiens_hsa005000.80101453
90Fatty acid degradation_Homo sapiens_hsa000710.79994266
91Oxytocin signaling pathway_Homo sapiens_hsa049210.78318530
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76678744
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76573833
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75791127
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75436618
96Melanogenesis_Homo sapiens_hsa049160.75394824
97Renin secretion_Homo sapiens_hsa049240.74617150
98Glucagon signaling pathway_Homo sapiens_hsa049220.74325226
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73902790
100Tight junction_Homo sapiens_hsa045300.73616585
101MAPK signaling pathway_Homo sapiens_hsa040100.72410509
102Fatty acid metabolism_Homo sapiens_hsa012120.72088140
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.71621124
104Measles_Homo sapiens_hsa051620.70405006
105* NF-kappa B signaling pathway_Homo sapiens_hsa040640.70189326
106RNA degradation_Homo sapiens_hsa030180.69546743
107Gap junction_Homo sapiens_hsa045400.69348366
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69343767
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69028763
110HIF-1 signaling pathway_Homo sapiens_hsa040660.68200285
111Influenza A_Homo sapiens_hsa051640.67457751
112Chemical carcinogenesis_Homo sapiens_hsa052040.67287116
113Basal cell carcinoma_Homo sapiens_hsa052170.66974490
114Axon guidance_Homo sapiens_hsa043600.66643398
115Amoebiasis_Homo sapiens_hsa051460.66495120
116Non-homologous end-joining_Homo sapiens_hsa034500.66116617
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65875140
118Focal adhesion_Homo sapiens_hsa045100.65838175
119Basal transcription factors_Homo sapiens_hsa030220.64798738
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64409358
121Leishmaniasis_Homo sapiens_hsa051400.63955156
122Pathways in cancer_Homo sapiens_hsa052000.63511657
123Butanoate metabolism_Homo sapiens_hsa006500.62482489
124Amphetamine addiction_Homo sapiens_hsa050310.62169812
125Arginine biosynthesis_Homo sapiens_hsa002200.62164300
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61492224
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60521950
128Salivary secretion_Homo sapiens_hsa049700.59222639
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59181260
130T cell receptor signaling pathway_Homo sapiens_hsa046600.58919919
131Epstein-Barr virus infection_Homo sapiens_hsa051690.58516019
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.58169819
133Toxoplasmosis_Homo sapiens_hsa051450.57508799
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.57038654
135Sphingolipid metabolism_Homo sapiens_hsa006000.56918303
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56772144
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.56244552
138Acute myeloid leukemia_Homo sapiens_hsa052210.55873465
139Platelet activation_Homo sapiens_hsa046110.55508819
140Cholinergic synapse_Homo sapiens_hsa047250.54870016
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54302510
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53514568
143Thyroid hormone synthesis_Homo sapiens_hsa049180.53212380
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53080787
145cAMP signaling pathway_Homo sapiens_hsa040240.53019434
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.52830904
147Fanconi anemia pathway_Homo sapiens_hsa034600.52405900
148Pertussis_Homo sapiens_hsa051330.51834555
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50935997
150Rap1 signaling pathway_Homo sapiens_hsa040150.50212573

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