TAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of vesicle fusion (GO:0031340)8.40570505
2L-glutamate transport (GO:0015813)8.03136601
3acidic amino acid transport (GO:0015800)7.74942226
4microtubule nucleation (GO:0007020)6.87920052
5peptidyl-arginine methylation (GO:0018216)5.82561176
6peptidyl-arginine N-methylation (GO:0035246)5.82561176
7centrosome localization (GO:0051642)5.77985097
8dermatan sulfate biosynthetic process (GO:0030208)5.55268839
9negative regulation of calcium ion transport into cytosol (GO:0010523)5.54371492
10presynaptic membrane assembly (GO:0097105)5.53021733
11neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)5.49332184
12negative regulation of Ras GTPase activity (GO:0034261)5.41427579
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.35411629
14positive regulation of growth hormone secretion (GO:0060124)5.33553983
15positive regulation of synaptic transmission, glutamatergic (GO:0051968)5.20441149
16regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18842410
17detection of temperature stimulus involved in sensory perception (GO:0050961)5.16851621
18detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.16851621
19establishment of protein localization to Golgi (GO:0072600)5.13510464
20somite rostral/caudal axis specification (GO:0032525)5.08903315
21axonal fasciculation (GO:0007413)5.04374973
22protein targeting to Golgi (GO:0000042)5.01505427
23dermatan sulfate metabolic process (GO:0030205)4.99082930
24G-protein coupled receptor internalization (GO:0002031)4.91394194
25detection of temperature stimulus (GO:0016048)4.90743106
26presynaptic membrane organization (GO:0097090)4.85331450
27regulation of protein kinase A signaling (GO:0010738)4.75220909
28peristalsis (GO:0030432)4.74588476
29retrograde transport, vesicle recycling within Golgi (GO:0000301)4.73262919
30regulation of vesicle fusion (GO:0031338)4.67861956
31positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.66467380
32histamine secretion (GO:0001821)4.65443910
33cellular response to ATP (GO:0071318)4.62073533
34regulation of clathrin-mediated endocytosis (GO:2000369)4.51634911
35behavioral defense response (GO:0002209)4.51431935
36behavioral fear response (GO:0001662)4.51431935
37regulation of penile erection (GO:0060405)4.50698299
38GTP biosynthetic process (GO:0006183)4.47570878
39prepulse inhibition (GO:0060134)4.38167512
40galactose catabolic process (GO:0019388)4.37380092
41neuronal action potential propagation (GO:0019227)4.29401004
42detection of calcium ion (GO:0005513)4.20005485
43suckling behavior (GO:0001967)4.17400694
44dicarboxylic acid transport (GO:0006835)4.10184110
45adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.08479985
46early endosome to late endosome transport (GO:0045022)4.08081720
47synaptic vesicle maturation (GO:0016188)4.04202571
48negative regulation of norepinephrine secretion (GO:0010700)3.94995015
49regulation of telomere maintenance (GO:0032204)3.94977256
50microtubule anchoring (GO:0034453)3.93397422
51synaptic transmission, dopaminergic (GO:0001963)3.93222163
52fear response (GO:0042596)3.90897191
53neuron recognition (GO:0008038)3.88654724
54peptidyl-threonine dephosphorylation (GO:0035970)3.88475841
55activation of adenylate cyclase activity (GO:0007190)3.84627252
56negative regulation of glial cell proliferation (GO:0060253)3.84221743
57cell migration in hindbrain (GO:0021535)3.83744507
58regulation of growth hormone secretion (GO:0060123)3.82410077
59UTP biosynthetic process (GO:0006228)3.81290074
60regulation of protein heterodimerization activity (GO:0043497)3.80683482
61chemosensory behavior (GO:0007635)3.76945149
62microtubule severing (GO:0051013)3.76618715
63protein localization to Golgi apparatus (GO:0034067)3.75307875
64synaptic vesicle exocytosis (GO:0016079)3.73928456
65neuronal ion channel clustering (GO:0045161)3.72584821
66negative regulation of acute inflammatory response (GO:0002674)3.71791079
67cilium or flagellum-dependent cell motility (GO:0001539)3.70708335
68axon regeneration (GO:0031103)3.69743799
69response to pheromone (GO:0019236)3.68871133
70synapse assembly (GO:0007416)3.66932643
71negative regulation of dendrite morphogenesis (GO:0050774)3.64430441
72striatum development (GO:0021756)3.63996531
73pyrimidine nucleobase catabolic process (GO:0006208)3.62499847
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.61381889
75regulation of neuronal synaptic plasticity (GO:0048168)3.60936785
76glutamate receptor signaling pathway (GO:0007215)3.60429790
77activation of protein kinase A activity (GO:0034199)3.60060940
78histamine transport (GO:0051608)3.59979688
79protein localization to synapse (GO:0035418)3.59140627
80peptidyl-arginine modification (GO:0018195)3.57140018
81vocalization behavior (GO:0071625)3.56127560
82startle response (GO:0001964)3.54976636
83auditory behavior (GO:0031223)3.54392238
84peptidyl-arginine omega-N-methylation (GO:0035247)3.53144656
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52759807
86positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.51670474
87response to auditory stimulus (GO:0010996)3.50064255
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.49910475
89positive regulation of Rap GTPase activity (GO:0032854)3.49088280
90positive regulation of adenylate cyclase activity (GO:0045762)3.47859201
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.47853897
92regulation of synaptic vesicle exocytosis (GO:2000300)3.46960304
93glutamate secretion (GO:0014047)3.46870058
94regulation of synapse structural plasticity (GO:0051823)3.45546040
95regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.45340833
96regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.45340833
97regulation of postsynaptic membrane potential (GO:0060078)3.44720668
98regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.44528086
99neuromuscular process controlling posture (GO:0050884)3.43129212
100C4-dicarboxylate transport (GO:0015740)3.41893432
101UTP metabolic process (GO:0046051)3.41139996
102regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41117753
103somite development (GO:0061053)3.40770200
104regulation of glutamate receptor signaling pathway (GO:1900449)3.40565030
105L-amino acid transport (GO:0015807)3.40496319
106positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.39515200
107negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38011484
108regulation of Rap GTPase activity (GO:0032317)3.33312243
109neuron-neuron synaptic transmission (GO:0007270)3.32688080
110dopamine receptor signaling pathway (GO:0007212)3.31595270
111neurotransmitter secretion (GO:0007269)3.30045420
112transmission of nerve impulse (GO:0019226)3.28035243
113retinal ganglion cell axon guidance (GO:0031290)3.27626814
114regulation of inositol phosphate biosynthetic process (GO:0010919)3.27151846
115resolution of meiotic recombination intermediates (GO:0000712)3.25525817
116locomotory exploration behavior (GO:0035641)3.24849338
117galactose metabolic process (GO:0006012)3.22836548
118* positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22722021
119sex differentiation (GO:0007548)3.22329826
120neurotransmitter transport (GO:0006836)3.21439215
121negative regulation of catecholamine secretion (GO:0033604)3.21432578
122behavioral response to cocaine (GO:0048148)3.20065787
123regulation of glutamate secretion (GO:0014048)3.16717403
124neuronal action potential (GO:0019228)3.16532733
125neuromuscular process controlling balance (GO:0050885)3.16249123
126neuron cell-cell adhesion (GO:0007158)3.16203765
127* regulation of synaptic transmission, GABAergic (GO:0032228)3.16088534
128regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.15406627
129regulation of collateral sprouting (GO:0048670)3.13987489
130ionotropic glutamate receptor signaling pathway (GO:0035235)3.13127659
131response to BMP (GO:0071772)3.11466498
132cellular response to BMP stimulus (GO:0071773)3.11466498
133positive regulation of gastrulation (GO:2000543)3.09995313
134S-adenosylmethionine metabolic process (GO:0046500)3.08579466
135* sensory perception of pain (GO:0019233)3.07642165
136positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07526904
137protein neddylation (GO:0045116)3.06576482
138negative regulation of dendrite development (GO:2000171)3.04305948
139mating behavior (GO:0007617)3.04290732
140synaptic transmission, glutamatergic (GO:0035249)3.03855551
141exploration behavior (GO:0035640)3.02758367
142DNA double-strand break processing (GO:0000729)3.02044506
143regulation of adenylate cyclase activity (GO:0045761)3.00957443
144negative regulation of GTP catabolic process (GO:0033125)3.00821755
145negative regulation of GTPase activity (GO:0034260)3.00821755
146neurotransmitter-gated ion channel clustering (GO:0072578)3.00383114
147response to histamine (GO:0034776)2.99570783
148negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.99480435
149intra-Golgi vesicle-mediated transport (GO:0006891)2.98654537
150response to amphetamine (GO:0001975)2.97999837
151signal transduction involved in regulation of gene expression (GO:0023019)2.95529288
152adenosine receptor signaling pathway (GO:0001973)2.95514865
153axon development (GO:0061564)2.94630395
154negative regulation of microtubule polymerization (GO:0031115)2.93842555
155negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93743071
156negative regulation of potassium ion transport (GO:0043267)2.93347726
157regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93269972
158gamma-aminobutyric acid transport (GO:0015812)2.92911087
159G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92581070
160regulation of synaptic vesicle transport (GO:1902803)2.92420527
161nucleobase catabolic process (GO:0046113)2.92107548
162cAMP-mediated signaling (GO:0019933)2.91439076
163* long-term memory (GO:0007616)2.91322353
164positive regulation of cyclase activity (GO:0031281)2.90284640
165embryonic foregut morphogenesis (GO:0048617)2.90160611
166regulation of female receptivity (GO:0045924)2.89469651
167layer formation in cerebral cortex (GO:0021819)2.88673346
168axon extension (GO:0048675)2.87107925
169RNA destabilization (GO:0050779)2.86462415
170axonogenesis (GO:0007409)2.86383133
171gamma-aminobutyric acid signaling pathway (GO:0007214)2.84908953
172regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84339259
173phasic smooth muscle contraction (GO:0014821)2.84284948
174adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.84008262
175negative regulation of transcription by competitive promoter binding (GO:0010944)2.83880450
176organelle transport along microtubule (GO:0072384)2.83564105
177* neuropeptide signaling pathway (GO:0007218)2.82665821
178nucleoside diphosphate phosphorylation (GO:0006165)2.82289174
179positive regulation of erythrocyte differentiation (GO:0045648)2.81997599
180heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.81832197
181ribonucleoprotein complex disassembly (GO:0032988)2.80575123
182transepithelial transport (GO:0070633)2.79040076
183postreplication repair (GO:0006301)2.78147750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28315125
2IGF1R_20145208_ChIP-Seq_DFB_Human3.38740663
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38573473
4* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.24958571
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20080878
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06772435
7GBX2_23144817_ChIP-Seq_PC3_Human3.06692348
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84269705
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83692114
10REST_21632747_ChIP-Seq_MESCs_Mouse2.79712750
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78379946
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78115047
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.76684064
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72989541
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71748344
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70737577
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.69437340
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.67359798
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66349525
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65167436
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62736509
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62736509
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.61578686
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.56033081
25VDR_22108803_ChIP-Seq_LS180_Human2.55003659
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54074548
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51924916
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.51877009
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.47399940
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41364546
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.33478391
32AR_21572438_ChIP-Seq_LNCaP_Human2.29886628
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.29300827
34* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18630152
35TAF15_26573619_Chip-Seq_HEK293_Human2.14222507
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13498775
37IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09410186
38EWS_26573619_Chip-Seq_HEK293_Human2.03894836
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.98550124
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.92920504
41DROSHA_22980978_ChIP-Seq_HELA_Human1.91671452
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87904332
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83205350
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74159675
45P300_19829295_ChIP-Seq_ESCs_Human1.71159847
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.69079382
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.62592406
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61762959
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59407838
50SMAD4_21799915_ChIP-Seq_A2780_Human1.59174729
51* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55565538
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54486285
53ZNF274_21170338_ChIP-Seq_K562_Hela1.51884016
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49284843
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47527456
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47217779
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46726866
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.45190602
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44660418
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44513926
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44062956
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41721346
63P53_22387025_ChIP-Seq_ESCs_Mouse1.41658208
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.41409370
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.38901616
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38897664
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.37330068
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37228206
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.37195285
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37118219
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35609999
72SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.32769543
73P300_18555785_Chip-Seq_ESCs_Mouse1.30608594
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.29642291
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28499284
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27222209
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.26648289
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26387368
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25239451
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25239451
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23666015
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.23534031
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22462001
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21501823
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21068506
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20937684
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20646851
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.19478418
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18416677
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17572857
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17542883
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16998421
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16920518
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15138724
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14304647
96CTCF_27219007_Chip-Seq_Bcells_Human1.13636603
97AHR_22903824_ChIP-Seq_MCF-7_Human1.13614780
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.13523366
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.13352440
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11903078
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10480436
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09176411
103RNF2_27304074_Chip-Seq_NSC_Mouse1.08541334
104AR_25329375_ChIP-Seq_VCAP_Human1.08365252
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.06485534
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.06149759
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05930836
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04626788
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04203080
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03554315
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03467623
112SOX2_19829295_ChIP-Seq_ESCs_Human1.01714007
113NANOG_19829295_ChIP-Seq_ESCs_Human1.01714007
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.01475070
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.99135243
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99125506
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.98971040
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98904349
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97176571
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.96073554
121* RUNX2_22187159_ChIP-Seq_PCA_Human0.95783175
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.94949835
123KDM2B_26808549_Chip-Seq_REH_Human0.94539746
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.94250597
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92286232
126KDM2B_26808549_Chip-Seq_K562_Human0.91464939
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91072585
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.89697251
129* STAT3_23295773_ChIP-Seq_U87_Human0.89215686
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87952466
131JUN_21703547_ChIP-Seq_K562_Human0.87942178
132* ER_23166858_ChIP-Seq_MCF-7_Human0.87660807
133AR_19668381_ChIP-Seq_PC3_Human0.87363225
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.85861210
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85158111
136TCF4_23295773_ChIP-Seq_U87_Human0.84951824
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84633542
138TP53_18474530_ChIP-ChIP_U2OS_Human0.82553586
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80764250
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77946374
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.75021937
142FUS_26573619_Chip-Seq_HEK293_Human0.73380115
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.73129403
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.71692992
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71160235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception5.14352914
2MP0001968_abnormal_touch/_nociception4.44662468
3MP0004859_abnormal_synaptic_plasticity4.37213391
4MP0004270_analgesia4.19601630
5MP0003880_abnormal_central_pattern3.97747747
6MP0002822_catalepsy3.76541912
7MP0006276_abnormal_autonomic_nervous3.72049593
8MP0002736_abnormal_nociception_after3.49683406
9MP0009745_abnormal_behavioral_response3.34313493
10MP0001986_abnormal_taste_sensitivity3.33759537
11MP0003635_abnormal_synaptic_transmissio3.23846908
12MP0002734_abnormal_mechanical_nocicepti3.14035937
13* MP0010386_abnormal_urinary_bladder3.09124367
14MP0001440_abnormal_grooming_behavior2.98019245
15MP0003787_abnormal_imprinting2.94801747
16MP0002733_abnormal_thermal_nociception2.91071246
17MP0002063_abnormal_learning/memory/cond2.88444625
18MP0003123_paternal_imprinting2.77586604
19* MP0001970_abnormal_pain_threshold2.74038666
20* MP0002572_abnormal_emotion/affect_behav2.59735813
21MP0009046_muscle_twitch2.58368740
22MP0002064_seizures2.55092761
23MP0002272_abnormal_nervous_system2.54074298
24MP0001529_abnormal_vocalization2.26578744
25MP0003121_genomic_imprinting2.18987363
26MP0001486_abnormal_startle_reflex2.02946635
27MP0002184_abnormal_innervation1.95074483
28MP0005386_behavior/neurological_phenoty1.93217949
29MP0004924_abnormal_behavior1.93217949
30MP0004133_heterotaxia1.88526202
31MP0004858_abnormal_nervous_system1.87773822
32MP0004145_abnormal_muscle_electrophysio1.87553098
33MP0002067_abnormal_sensory_capabilities1.85135809
34MP0005187_abnormal_penis_morphology1.83088749
35MP0001501_abnormal_sleep_pattern1.79257933
36MP0005423_abnormal_somatic_nervous1.77571362
37MP0001188_hyperpigmentation1.72897987
38MP0000538_abnormal_urinary_bladder1.70612190
39MP0001905_abnormal_dopamine_level1.68322668
40MP0002909_abnormal_adrenal_gland1.63816464
41MP0000569_abnormal_digit_pigmentation1.55729471
42MP0003221_abnormal_cardiomyocyte_apopto1.55077287
43MP0002557_abnormal_social/conspecific_i1.50392900
44MP0005410_abnormal_fertilization1.46385768
45MP0004142_abnormal_muscle_tone1.43934953
46MP0000751_myopathy1.37598394
47MP0003283_abnormal_digestive_organ1.37080367
48MP0003195_calcinosis1.36659534
49MP0003329_amyloid_beta_deposits1.35568746
50MP0008872_abnormal_physiological_respon1.35493810
51MP0008877_abnormal_DNA_methylation1.34373517
52MP0004811_abnormal_neuron_physiology1.32110004
53MP0008569_lethality_at_weaning1.30175071
54MP0001727_abnormal_embryo_implantation1.28898121
55MP0003890_abnormal_embryonic-extraembry1.28141820
56MP0002882_abnormal_neuron_morphology1.24992136
57MP0002066_abnormal_motor_capabilities/c1.24462001
58MP0003879_abnormal_hair_cell1.24135345
59MP0005535_abnormal_body_temperature1.20326423
60MP0001984_abnormal_olfaction1.19942478
61MP0000778_abnormal_nervous_system1.18098000
62MP0003122_maternal_imprinting1.17625110
63MP0008874_decreased_physiological_sensi1.16604928
64MP0000631_abnormal_neuroendocrine_gland1.12228974
65MP0001919_abnormal_reproductive_system1.10712093
66MP0000955_abnormal_spinal_cord1.09316739
67MP0002234_abnormal_pharynx_morphology1.08251464
68MP0001502_abnormal_circadian_rhythm1.06225943
69MP0005503_abnormal_tendon_morphology1.03732744
70MP0004147_increased_porphyrin_level1.01994822
71MP0006072_abnormal_retinal_apoptosis1.01480327
72MP0003119_abnormal_digestive_system0.99651059
73MP0008775_abnormal_heart_ventricle0.98645978
74MP0000920_abnormal_myelination0.95580197
75MP0004085_abnormal_heartbeat0.93571943
76MP0003633_abnormal_nervous_system0.93262897
77MP0002837_dystrophic_cardiac_calcinosis0.93250689
78MP0005367_renal/urinary_system_phenotyp0.92100239
79MP0000516_abnormal_urinary_system0.92100239
80MP0004484_altered_response_of0.91034029
81MP0004742_abnormal_vestibular_system0.90926212
82MP0002160_abnormal_reproductive_system0.90407174
83MP0002751_abnormal_autonomic_nervous0.88314175
84MP0000647_abnormal_sebaceous_gland0.87718252
85MP0002229_neurodegeneration0.87399552
86MP0004885_abnormal_endolymph0.87182365
87MP0003183_abnormal_peptide_metabolism0.86174298
88MP0009780_abnormal_chondrocyte_physiolo0.84278056
89MP0003315_abnormal_perineum_morphology0.82803644
90MP0000026_abnormal_inner_ear0.81692098
91MP0002752_abnormal_somatic_nervous0.81440870
92MP0005248_abnormal_Harderian_gland0.78195705
93MP0001963_abnormal_hearing_physiology0.77251942
94MP0005670_abnormal_white_adipose0.76877399
95MP0003385_abnormal_body_wall0.76802765
96MP0002069_abnormal_eating/drinking_beha0.76569227
97MP0005551_abnormal_eye_electrophysiolog0.75415643
98MP0003634_abnormal_glial_cell0.74735863
99MP0003137_abnormal_impulse_conducting0.74325877
100MP0001542_abnormal_bone_strength0.74243991
101MP0003631_nervous_system_phenotype0.72842512
102MP0004036_abnormal_muscle_relaxation0.71122225
103MP0000427_abnormal_hair_cycle0.68477752
104MP0000604_amyloidosis0.66745418
105MP0000465_gastrointestinal_hemorrhage0.66550017
106MP0003690_abnormal_glial_cell0.66346046
107MP0005646_abnormal_pituitary_gland0.63952929
108MP0001485_abnormal_pinna_reflex0.61646841
109MP0002152_abnormal_brain_morphology0.60252081
110MP0000015_abnormal_ear_pigmentation0.60155311
111MP0005389_reproductive_system_phenotype0.58097496
112MP0000747_muscle_weakness0.57013018
113MP0003567_abnormal_fetal_cardiomyocyte0.56950885
114MP0001299_abnormal_eye_distance/0.56571941
115MP0000230_abnormal_systemic_arterial0.56502928
116MP0003252_abnormal_bile_duct0.55509626
117MP0005645_abnormal_hypothalamus_physiol0.54510796
118MP0010307_abnormal_tumor_latency0.53620935
119MP0002177_abnormal_outer_ear0.53402783
120MP0000639_abnormal_adrenal_gland0.53238753
121MP0000013_abnormal_adipose_tissue0.53215419
122MP0006036_abnormal_mitochondrial_physio0.52439528
123MP0005195_abnormal_posterior_eye0.51994942
124MP0005083_abnormal_biliary_tract0.50803378
125MP0005448_abnormal_energy_balance0.49456007
126MP0003941_abnormal_skin_development0.48245238
127MP0003075_altered_response_to0.47899987
128MP0000579_abnormal_nail_morphology0.47404249
129MP0002876_abnormal_thyroid_physiology0.46753937
130MP0002090_abnormal_vision0.46241705
131MP0001177_atelectasis0.46015425
132MP0000749_muscle_degeneration0.45238138
133MP0001664_abnormal_digestion0.45204983
134MP0001765_abnormal_ion_homeostasis0.45052526
135MP0004883_abnormal_blood_vessel0.44339959
136MP0001943_abnormal_respiration0.44011797
137MP0005409_darkened_coat_color0.43889835
138MP0006035_abnormal_mitochondrial_morpho0.43338375

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.01075619
2Hip dysplasia (HP:0001385)7.50558226
3Thoracolumbar scoliosis (HP:0002944)7.45359454
4Focal motor seizures (HP:0011153)6.15170148
5Calf muscle hypertrophy (HP:0008981)5.04369534
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.87027269
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.87027269
8Difficulty running (HP:0009046)4.83934593
9Increased density of long bones (HP:0006392)4.81436360
10Shoulder girdle muscle weakness (HP:0003547)4.45960500
11Focal seizures (HP:0007359)4.39458722
12Pelvic girdle muscle weakness (HP:0003749)4.34748019
13Abnormality of the musculature of the pelvis (HP:0001469)3.90732559
14Abnormality of the hip-girdle musculature (HP:0001445)3.90732559
15Inappropriate behavior (HP:0000719)3.83335260
16Atonic seizures (HP:0010819)3.81095686
17Action tremor (HP:0002345)3.66709766
18Epileptic encephalopathy (HP:0200134)3.64710502
19Abnormality of pain sensation (HP:0010832)3.62648198
20Impaired pain sensation (HP:0007328)3.62648198
21Anxiety (HP:0000739)3.59743866
22Pheochromocytoma (HP:0002666)3.54372974
23Myotonia (HP:0002486)3.51301310
24Progressive cerebellar ataxia (HP:0002073)3.48664497
25Annular pancreas (HP:0001734)3.47582458
26Aplasia/Hypoplasia of the tibia (HP:0005772)3.47110913
27Visual hallucinations (HP:0002367)3.46142965
28Febrile seizures (HP:0002373)3.36281739
29Absence seizures (HP:0002121)3.35765577
30Sensory axonal neuropathy (HP:0003390)3.32171116
31Genetic anticipation (HP:0003743)3.31720876
32Abnormal eating behavior (HP:0100738)3.31298102
33Fibular aplasia (HP:0002990)3.23747827
34Neuroendocrine neoplasm (HP:0100634)3.22666756
35Megalencephaly (HP:0001355)3.21790237
36Short tibia (HP:0005736)3.17307942
37Neoplasm of the peripheral nervous system (HP:0100007)3.15359046
38Obstructive sleep apnea (HP:0002870)3.15194394
39Protruding tongue (HP:0010808)3.14997958
40Generalized tonic-clonic seizures (HP:0002069)3.08453902
41Abnormal hair whorl (HP:0010721)3.05835054
42Disinhibition (HP:0000734)3.05568428
43Abnormality of the ischium (HP:0003174)3.00941080
44Sleep apnea (HP:0010535)2.97719915
45Depression (HP:0000716)2.96055950
46Dialeptic seizures (HP:0011146)2.95018754
47Rib fusion (HP:0000902)2.90020135
48Supranuclear gaze palsy (HP:0000605)2.88752556
49Abnormality of the 2nd finger (HP:0004100)2.88065445
50Severe short stature (HP:0003510)2.86793755
51Decreased muscle mass (HP:0003199)2.86782806
52Resting tremor (HP:0002322)2.85281801
53Renal cortical cysts (HP:0000803)2.84017640
54Hypoplastic ischia (HP:0003175)2.82153028
55Scanning speech (HP:0002168)2.80658257
56Difficulty climbing stairs (HP:0003551)2.77045069
57Abnormal gallbladder physiology (HP:0012438)2.76993114
58Cholecystitis (HP:0001082)2.76993114
59Hypoventilation (HP:0002791)2.75251483
60Truncal ataxia (HP:0002078)2.74426667
61Unilateral renal agenesis (HP:0000122)2.73169565
62Poor suck (HP:0002033)2.70470921
63Sudden death (HP:0001699)2.69316042
64Hyperventilation (HP:0002883)2.69156750
65Torticollis (HP:0000473)2.68196526
66Ankle clonus (HP:0011448)2.67127211
67Macroorchidism (HP:0000053)2.67124306
68Failure to thrive in infancy (HP:0001531)2.64543663
69Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.60251225
70Down-sloping shoulders (HP:0200021)2.60081493
71Dysmetria (HP:0001310)2.58977636
72Fair hair (HP:0002286)2.56236324
73Craniofacial dystonia (HP:0012179)2.53697352
74Testicular atrophy (HP:0000029)2.49484466
75Focal dystonia (HP:0004373)2.49227291
76Shawl scrotum (HP:0000049)2.46498630
77Drooling (HP:0002307)2.42602400
78Progressive inability to walk (HP:0002505)2.40310940
79Long toe (HP:0010511)2.38698701
80Nuclear cataract (HP:0100018)2.36963771
81Intellectual disability, severe (HP:0010864)2.36767757
82Delusions (HP:0000746)2.36549903
83Prominent nose (HP:0000448)2.35788049
84Hypercortisolism (HP:0001578)2.35373022
85Mutism (HP:0002300)2.27480073
86Acute necrotizing encephalopathy (HP:0006965)2.27311181
87Dysdiadochokinesis (HP:0002075)2.27143113
88Broad-based gait (HP:0002136)2.24391946
89Excessive salivation (HP:0003781)2.24365676
90Exotropia (HP:0000577)2.23010847
91Urinary urgency (HP:0000012)2.21565775
92Psychosis (HP:0000709)2.21209317
93Hypokinesia (HP:0002375)2.19507903
94Gait imbalance (HP:0002141)2.19403178
95Neurofibrillary tangles (HP:0002185)2.18731536
96Polyphagia (HP:0002591)2.17764030
97Proximal tubulopathy (HP:0000114)2.14029386
98Abnormality of the frontal sinuses (HP:0002687)2.13743739
99Papillary thyroid carcinoma (HP:0002895)2.13249711
100Amblyopia (HP:0000646)2.12248564
101Absent eyebrow (HP:0002223)2.11011328
102Microtia (HP:0008551)2.09962050
103Limb dystonia (HP:0002451)2.09330053
104Oligomenorrhea (HP:0000876)2.09192711
105Insidious onset (HP:0003587)2.08894099
106Termporal pattern (HP:0011008)2.08894099
107Bronchomalacia (HP:0002780)2.08687225
108Curly hair (HP:0002212)2.08660698
109Increased hepatocellular lipid droplets (HP:0006565)2.07047746
110Barrel-shaped chest (HP:0001552)2.06362048
111Spastic gait (HP:0002064)2.06175522
112Tetraplegia (HP:0002445)2.06096707
113Abnormal mitochondria in muscle tissue (HP:0008316)2.06077080
114Short phalanx of the thumb (HP:0009660)2.05952804
115Abnormality of the corticospinal tract (HP:0002492)2.05800981
116Impaired vibration sensation in the lower limbs (HP:0002166)2.03569832
117Foot dorsiflexor weakness (HP:0009027)2.03530684
118Urinary bladder sphincter dysfunction (HP:0002839)2.03493091
119Gaze-evoked nystagmus (HP:0000640)2.03001818
120Lipid accumulation in hepatocytes (HP:0006561)2.02510153
121Bradykinesia (HP:0002067)2.01717962
122Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.01629125
123Testicular neoplasm (HP:0010788)2.01050678
124Hypotelorism (HP:0000601)2.00513887
125Cerebral hemorrhage (HP:0001342)1.99339550
126Amyotrophic lateral sclerosis (HP:0007354)1.97223404
127Severe global developmental delay (HP:0011344)1.96569643
128Progressive macrocephaly (HP:0004481)1.96369278
129Generalized hypotonia (HP:0001290)1.95678777
130Congenital primary aphakia (HP:0007707)1.92208701
131Restlessness (HP:0000711)1.92160277
132Hypophosphatemic rickets (HP:0004912)1.91442221
133Rapidly progressive (HP:0003678)1.91023338
134Neuronal loss in central nervous system (HP:0002529)1.91016571
135Apathy (HP:0000741)1.90909936
136Lower limb muscle weakness (HP:0007340)1.90814872
137Limb-girdle muscle weakness (HP:0003325)1.90542951
138Abnormality of the calf musculature (HP:0001430)1.90525758
139Broad distal phalanx of finger (HP:0009836)1.89238487
140Papilledema (HP:0001085)1.89099411
141Spinal canal stenosis (HP:0003416)1.88902894
142Poor eye contact (HP:0000817)1.86239574
143Type II lissencephaly (HP:0007260)1.86177992
144Macroglossia (HP:0000158)1.85796330
145Abnormality of calcium-phosphate metabolism (HP:0100530)1.85608308
146Morphological abnormality of the pyramidal tract (HP:0002062)1.85353404
147Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85210843
148Retinal dysplasia (HP:0007973)1.84362115
149Agitation (HP:0000713)1.82954458
150Achilles tendon contracture (HP:0001771)1.82445204
151Neuroblastoma (HP:0003006)1.82427855
152Primitive neuroectodermal tumor (HP:0030065)1.82427855
153Neuroblastic tumors (HP:0004376)1.82427855
154Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.82427855
155Neoplasm of the heart (HP:0100544)1.82374064
156Stereotypic behavior (HP:0000733)1.81764002
157Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.81515248
158Generalized hypopigmentation of hair (HP:0011358)1.80627222
159Muscle hypertrophy of the lower extremities (HP:0008968)1.79685656
160Primary amenorrhea (HP:0000786)1.79414584
161Acute encephalopathy (HP:0006846)1.79362650
162Impaired social interactions (HP:0000735)1.78605460
163Abnormal social behavior (HP:0012433)1.78605460
164Diminished motivation (HP:0000745)1.78484069
165Specific learning disability (HP:0001328)1.78384299
166Postural instability (HP:0002172)1.78083431
167Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.77139104
168Parakeratosis (HP:0001036)1.77016595
169Clumsiness (HP:0002312)1.76553351
170Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.74990640
171Short 1st metacarpal (HP:0010034)1.74990640
172Spondylolisthesis (HP:0003302)1.74813795
173Anomalous pulmonary venous return (HP:0010772)1.73227680
174Humeroradial synostosis (HP:0003041)1.72098879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DYRK33.72420989
2NTRK13.60435042
3NTRK33.43402067
4ADRBK23.33076034
5KSR23.32704269
6EPHA43.30621064
7PKN23.04454871
8MAP3K123.02162398
9MAP3K92.94670711
10RPS6KA42.68756525
11ARAF2.66802096
12MST42.55117514
13MAP3K22.53756084
14GRK52.46520721
15RIPK42.44654114
16MINK12.38889832
17FLT32.27547762
18CASK2.16079166
19DAPK22.08076505
20LIMK11.78846366
21EPHB21.77621711
22MARK11.59000097
23CDK51.48426952
24MAP2K41.45545148
25DAPK11.38619602
26TNIK1.36073338
27MAPK131.32621010
28ERBB31.30741891
29FER1.26460520
30STK381.25466565
31LMTK21.24636562
32MAP3K11.23222554
33MAP3K41.22881426
34NTRK21.22328504
35FES1.21299969
36UHMK11.21149294
37MAP2K71.19443192
38SIK31.18366378
39FRK1.17152841
40MAP3K61.13515170
41CDK191.12619770
42RET1.10739942
43TAOK11.08995733
44DYRK21.06100020
45LATS11.04973065
46CAMKK11.04063201
47CDK141.00842233
48TNK21.00481509
49NME10.99420516
50MAP3K130.93510233
51PAK60.92568104
52CAMK40.91236024
53KSR10.89989538
54DYRK1A0.89343524
55CDK180.88877027
56DAPK30.88563774
57MAP2K10.87665894
58STK160.87089915
59PRKCE0.85244324
60ROCK10.85136108
61PRKCG0.84040462
62ROCK20.83382728
63SIK20.82812665
64CDK150.82593515
65PRKD30.82236443
66PHKG20.81987020
67PHKG10.81987020
68TESK10.81638108
69WNK30.81068819
70PRPF4B0.80983366
71MAPKAPK30.80651342
72MATK0.79000785
73BCKDK0.77763422
74PINK10.76089707
75ZAK0.74493791
76MARK20.74435064
77CAMK2B0.74423866
78PRKCZ0.73452915
79CAMK2A0.72029441
80MYLK0.71341505
81CDK11A0.70747929
82SGK4940.70033668
83SGK2230.70033668
84BCR0.68954774
85OXSR10.68531229
86STK240.68135239
87TLK10.67907757
88PLK20.66857488
89MAP3K50.66747332
90CAMKK20.65924111
91CAMK2D0.63461031
92KDR0.63054844
93PRKCH0.62857828
94AKT30.61702897
95ADRBK10.61303000
96LATS20.61211142
97PDPK10.60154403
98MKNK20.59895504
99STK110.59401699
100BRAF0.59399308
101DYRK1B0.58128831
102PRKG10.56373104
103CSNK1G20.56130732
104PTK2B0.55446792
105PNCK0.54155051
106RAF10.54032478
107SGK30.53903303
108MAPKAPK50.53792701
109PRKACB0.52467088
110TIE10.52463124
111SCYL20.52293820
112RPS6KA20.52205351
113PDK10.51140355
114TRIM280.50982521
115BMPR20.49905540
116TGFBR10.48578754
117PDK30.48204401
118PDK40.48204401
119MAP2K30.47214475
120PRKACA0.46500427
121MAP3K70.45611300
122LRRK20.44898586
123STK38L0.44245482
124MAPK40.44166984
125CAMK2G0.42098237
126FYN0.41838189
127SGK20.41661957
128CSNK1G30.41388657
129GSK3A0.40652722
130NEK10.39370144
131FGR0.37780279
132RPS6KA50.37705760
133STK390.37311384
134MAP2K60.36975965
135BMPR1B0.36234075
136PAK30.36112990
137RIPK10.35916697
138PKN10.35484035
139SRPK10.34589257
140CDK80.33330236
141TYRO30.33212111
142SRC0.33201815
143MARK30.31884845
144PRKD20.31350352
145GRK10.30372143
146CSNK1A1L0.30318347
147STK30.28252629
148INSRR0.27761867
149PRKD10.27017565
150CSNK1G10.25491674

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.53183183
2Synaptic vesicle cycle_Homo sapiens_hsa047213.10074554
3Olfactory transduction_Homo sapiens_hsa047402.74315707
4Nicotine addiction_Homo sapiens_hsa050332.69287240
5GABAergic synapse_Homo sapiens_hsa047272.53574146
6Oxidative phosphorylation_Homo sapiens_hsa001902.46384896
7Morphine addiction_Homo sapiens_hsa050322.36286434
8Protein export_Homo sapiens_hsa030602.32533420
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28501146
10Collecting duct acid secretion_Homo sapiens_hsa049662.26161983
11Long-term potentiation_Homo sapiens_hsa047202.21129904
12Parkinsons disease_Homo sapiens_hsa050122.19324457
13Glutamatergic synapse_Homo sapiens_hsa047242.16483715
14Renin secretion_Homo sapiens_hsa049242.15914538
15Circadian entrainment_Homo sapiens_hsa047132.12481798
16Insulin secretion_Homo sapiens_hsa049112.03660017
17Dopaminergic synapse_Homo sapiens_hsa047281.97371061
18Amphetamine addiction_Homo sapiens_hsa050311.90949014
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90401417
20Regulation of autophagy_Homo sapiens_hsa041401.85491837
21Cardiac muscle contraction_Homo sapiens_hsa042601.78217414
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76997788
23Cholinergic synapse_Homo sapiens_hsa047251.76982682
24Gastric acid secretion_Homo sapiens_hsa049711.76600955
25Serotonergic synapse_Homo sapiens_hsa047261.75331578
26Long-term depression_Homo sapiens_hsa047301.74785950
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.73375828
28Alzheimers disease_Homo sapiens_hsa050101.72070626
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71362559
30Cocaine addiction_Homo sapiens_hsa050301.69730478
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64402413
32Salivary secretion_Homo sapiens_hsa049701.59519519
33Taste transduction_Homo sapiens_hsa047421.52195064
34GnRH signaling pathway_Homo sapiens_hsa049121.49302244
35Oxytocin signaling pathway_Homo sapiens_hsa049211.39632597
36Gap junction_Homo sapiens_hsa045401.38085680
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37570611
38Starch and sucrose metabolism_Homo sapiens_hsa005001.36592766
39Vibrio cholerae infection_Homo sapiens_hsa051101.26515199
40Huntingtons disease_Homo sapiens_hsa050161.25794645
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24539878
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23774117
43Estrogen signaling pathway_Homo sapiens_hsa049151.13625852
44cAMP signaling pathway_Homo sapiens_hsa040241.13348801
45Calcium signaling pathway_Homo sapiens_hsa040201.12791479
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10339996
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08922680
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06871881
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02673902
50Glioma_Homo sapiens_hsa052141.01050399
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97813959
52Melanogenesis_Homo sapiens_hsa049160.95662512
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.94813968
54Folate biosynthesis_Homo sapiens_hsa007900.93333180
55Phototransduction_Homo sapiens_hsa047440.93250711
56Sulfur metabolism_Homo sapiens_hsa009200.92950125
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90242692
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.88609426
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87364916
60Thyroid cancer_Homo sapiens_hsa052160.86579547
61Sphingolipid metabolism_Homo sapiens_hsa006000.83478399
62VEGF signaling pathway_Homo sapiens_hsa043700.81445087
63Axon guidance_Homo sapiens_hsa043600.81146368
64Oocyte meiosis_Homo sapiens_hsa041140.74977909
65Non-small cell lung cancer_Homo sapiens_hsa052230.73969450
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72971866
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.70457133
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70223274
69MAPK signaling pathway_Homo sapiens_hsa040100.68940221
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65374978
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65348594
72ErbB signaling pathway_Homo sapiens_hsa040120.65151962
73Fatty acid biosynthesis_Homo sapiens_hsa000610.64676563
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64587529
75Prion diseases_Homo sapiens_hsa050200.63488795
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.63224038
77Nitrogen metabolism_Homo sapiens_hsa009100.63177409
78Other glycan degradation_Homo sapiens_hsa005110.61542795
79Bile secretion_Homo sapiens_hsa049760.61272388
80Dilated cardiomyopathy_Homo sapiens_hsa054140.60981592
81Melanoma_Homo sapiens_hsa052180.60944069
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60681192
83Dorso-ventral axis formation_Homo sapiens_hsa043200.59085821
84Ras signaling pathway_Homo sapiens_hsa040140.57323504
85Type II diabetes mellitus_Homo sapiens_hsa049300.57084343
86Thyroid hormone synthesis_Homo sapiens_hsa049180.57067081
87Alcoholism_Homo sapiens_hsa050340.56071257
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56020276
89Choline metabolism in cancer_Homo sapiens_hsa052310.53786371
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53356287
91Type I diabetes mellitus_Homo sapiens_hsa049400.52330463
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52096745
93AMPK signaling pathway_Homo sapiens_hsa041520.51665649
94Rap1 signaling pathway_Homo sapiens_hsa040150.51601568
95Rheumatoid arthritis_Homo sapiens_hsa053230.51236226
96Glucagon signaling pathway_Homo sapiens_hsa049220.51089617
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51032863
98Renal cell carcinoma_Homo sapiens_hsa052110.48837108
99Endocytosis_Homo sapiens_hsa041440.48319708
100Insulin signaling pathway_Homo sapiens_hsa049100.47161616
101Endometrial cancer_Homo sapiens_hsa052130.46669144
102Circadian rhythm_Homo sapiens_hsa047100.44952844
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43211301
104Pancreatic secretion_Homo sapiens_hsa049720.41935314
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41526201
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41425129
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41401055
108Arginine biosynthesis_Homo sapiens_hsa002200.40351407
109Chemical carcinogenesis_Homo sapiens_hsa052040.39782519
110Bladder cancer_Homo sapiens_hsa052190.39755257
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38991388
112Ovarian steroidogenesis_Homo sapiens_hsa049130.38633908
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38428881
114Hippo signaling pathway_Homo sapiens_hsa043900.38401481
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37940696
116Phenylalanine metabolism_Homo sapiens_hsa003600.37779684
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36545306
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.35105855
119Butanoate metabolism_Homo sapiens_hsa006500.32890829
120Phagosome_Homo sapiens_hsa041450.32484095
121Retinol metabolism_Homo sapiens_hsa008300.32221136
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29738512
123TGF-beta signaling pathway_Homo sapiens_hsa043500.29071917
124Platelet activation_Homo sapiens_hsa046110.28034470
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27113775
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26754649
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.25719563
128RNA degradation_Homo sapiens_hsa030180.23703273
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.23267571
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22968397
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22503017
132Fanconi anemia pathway_Homo sapiens_hsa034600.22254300
133ABC transporters_Homo sapiens_hsa020100.20958320
134Caffeine metabolism_Homo sapiens_hsa002320.20335987
135Vitamin digestion and absorption_Homo sapiens_hsa049770.19237662
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18916764
137Linoleic acid metabolism_Homo sapiens_hsa005910.17842334

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