ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	embryonic retina morphogenesis in camera-type eye (GO:0060059)	7.33830470
2	response to gravity (GO:0009629)	6.96508819
3	substrate-independent telencephalic tangential migration (GO:0021826)	6.38699507
4	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	6.38699507
5	neurofilament cytoskeleton organization (GO:0060052)	5.58622473
6	mitochondrion transport along microtubule (GO:0047497)	5.55507078
7	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	5.55507078
8	regulation of bile acid biosynthetic process (GO:0070857)	5.41090114
9	establishment of mitochondrion localization (GO:0051654)	5.35773141
10	neuronal ion channel clustering (GO:0045161)	5.35759785
11	forebrain neuron differentiation (GO:0021879)	5.29049138
12	regulation of sarcomere organization (GO:0060297)	5.13743376
13	cerebellar granule cell differentiation (GO:0021707)	5.11819712
14	cellular response to vitamin D (GO:0071305)	5.11276911
15	locomotory exploration behavior (GO:0035641)	4.87158979
16	presynaptic membrane organization (GO:0097090)	4.76653507
17	regulation of cilium movement (GO:0003352)	4.72737686
18	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.70680918
19	positive regulation of growth hormone secretion (GO:0060124)	4.64599895
20	cerebellar Purkinje cell differentiation (GO:0021702)	4.50862700
21	head development (GO:0060322)	4.44219173
22	pyrimidine nucleobase catabolic process (GO:0006208)	4.42612191
23	response to phenylpropanoid (GO:0080184)	4.41456200
24	cell differentiation in hindbrain (GO:0021533)	4.33912196
25	uterus development (GO:0060065)	4.26491253
26	positive regulation of gastrulation (GO:2000543)	4.25529806
27	short-term memory (GO:0007614)	4.17297309
28	chemosensory behavior (GO:0007635)	4.15037836
29	positive regulation of cell cycle checkpoint (GO:1901978)	4.14143800
30	lymphangiogenesis (GO:0001946)	3.99134071
31	neuron recognition (GO:0008038)	3.93553285
32	axon ensheathment in central nervous system (GO:0032291)	3.93215524
33	central nervous system myelination (GO:0022010)	3.93215524
34	parturition (GO:0007567)	3.92688697
35	axonal fasciculation (GO:0007413)	3.92384329
36	regulation of microtubule-based movement (GO:0060632)	3.91354642
37	exploration behavior (GO:0035640)	3.86154180
38	venous blood vessel morphogenesis (GO:0048845)	3.77689874
39	synaptic transmission, dopaminergic (GO:0001963)	3.77135891
40	chaperone-mediated protein transport (GO:0072321)	3.75662534
41	behavioral response to nicotine (GO:0035095)	3.73912103
42	behavioral response to ethanol (GO:0048149)	3.73738238
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.71102747
44	spinal cord association neuron differentiation (GO:0021527)	3.67970493
45	cellular response to vitamin (GO:0071295)	3.63608057
46	protein polyglutamylation (GO:0018095)	3.61434934
47	neuronal action potential propagation (GO:0019227)	3.60258497
48	urogenital system development (GO:0001655)	3.49049045
49	dentate gyrus development (GO:0021542)	3.44425029
50	ganglion development (GO:0061548)	3.43847960
51	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.36872482
52	nucleobase catabolic process (GO:0046113)	3.36436999
53	regulation of growth hormone secretion (GO:0060123)	3.36053147
54	regulation of telomerase activity (GO:0051972)	3.33293792
55	protein localization to synapse (GO:0035418)	3.32145002
56	protein neddylation (GO:0045116)	3.30528530
57	synapse assembly (GO:0007416)	3.26081847
58	ectodermal placode formation (GO:0060788)	3.25392074
59	glycerophospholipid catabolic process (GO:0046475)	3.22909331
60	behavioral response to cocaine (GO:0048148)	3.22356788
61	striatum development (GO:0021756)	3.21718371
62	negative regulation of appetite (GO:0032099)	3.20862132
63	negative regulation of response to food (GO:0032096)	3.20862132
64	response to histamine (GO:0034776)	3.20128772
65	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.19873409
66	regulation of synapse structural plasticity (GO:0051823)	3.17324553
67	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.13344645
68	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.13344645
69	body morphogenesis (GO:0010171)	3.05039967
70	mitochondrion localization (GO:0051646)	3.04233899
71	negative regulation of neurotransmitter secretion (GO:0046929)	3.02913211
72	neuronal stem cell maintenance (GO:0097150)	3.02760803
73	cell aggregation (GO:0098743)	3.01859991
74	cartilage condensation (GO:0001502)	3.01859991
75	nonmotile primary cilium assembly (GO:0035058)	3.01808894
76	cell migration in hindbrain (GO:0021535)	3.01226933
77	hepatocyte differentiation (GO:0070365)	3.00458912
78	transmission of nerve impulse (GO:0019226)	2.99985488
79	innervation (GO:0060384)	2.99178821
80	olfactory bulb development (GO:0021772)	2.94423522
81	adult walking behavior (GO:0007628)	2.90923237
82	positive regulation of neurotransmitter transport (GO:0051590)	2.89472821
83	microtubule bundle formation (GO:0001578)	2.86980915
84	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84827312
85	pre-miRNA processing (GO:0031054)	2.83004803
86	axon extension (GO:0048675)	2.82039490
87	glutamate secretion (GO:0014047)	2.81264270
88	organelle transport along microtubule (GO:0072384)	2.79253588
89	axon cargo transport (GO:0008088)	2.78704879
90	embryonic body morphogenesis (GO:0010172)	2.75235486
91	negative regulation of heart rate (GO:0010459)	2.75037084
92	cytoskeleton-dependent intracellular transport (GO:0030705)	2.73319621
93	hypothalamus development (GO:0021854)	2.70571608
94	endoderm formation (GO:0001706)	2.65052831
95	regulation of voltage-gated calcium channel activity (GO:1901385)	2.64009705
96	microtubule-based transport (GO:0010970)	2.62912753
97	negative regulation of catecholamine secretion (GO:0033604)	2.61915121
98	icosanoid secretion (GO:0032309)	2.61631660
99	arachidonic acid secretion (GO:0050482)	2.61631660
100	positive regulation of organelle assembly (GO:1902117)	2.60246880

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.81361689
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.98907087
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.16743066
4	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.08727174
5	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.82654860
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.71406425
7	REST_21632747_ChIP-Seq_MESCs_Mouse	2.69922873
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.55917567
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.47963979
10	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.22327408
11	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.11552228
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.10272772
13	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.05904580
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.01822612
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01203481
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.99472572
17	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.94171069
18	RNF2_27304074_Chip-Seq_NSC_Mouse	1.93898373
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93343123
20	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.89588080
21	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.89588080
22	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.78743760
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.78060081
24	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.77861376
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.76823347
26	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.70795911
27	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.67372519
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58051491
29	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.55463247
30	CTCF_27219007_Chip-Seq_Bcells_Human	1.53561119
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51499640
32	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.51487408
33	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.51111037
34	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.48804521
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46274538
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45332919
37	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.44172327
38	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.44097110
39	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.43792108
40	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.41276465
41	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.39726791
42	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.37864364
43	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.37846959
44	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.37615000
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25170009
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23440444
47	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.22403919
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.21777757
49	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.21021995
50	VDR_22108803_ChIP-Seq_LS180_Human	1.20234059
51	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.16696075
52	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.16377631
53	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.13402491
54	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11171793
55	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.09047124
56	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08570252
57	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.06537755
58	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06103412
59	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06028145
60	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.04823502
61	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.02352187
62	P300_19829295_ChIP-Seq_ESCs_Human	1.02044846
63	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.01008454
64	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.00595106
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00441004
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00441004
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99971352
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.98447252
69	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.98035568
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.96871148
71	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.96235497
72	TP53_22573176_ChIP-Seq_HFKS_Human	0.94456451
73	NCOR_22424771_ChIP-Seq_293T_Human	0.94287718
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93799328
75	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.92948412
76	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.90636137
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89510424
78	AR_25329375_ChIP-Seq_VCAP_Human	0.89467992
79	JUN_21703547_ChIP-Seq_K562_Human	0.88893483
80	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.87479941
81	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.85989606
82	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.85730683
83	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.84899624
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.84538296
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.83647053
86	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.83122194
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.81507690
88	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.80811842
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.80449892
90	FUS_26573619_Chip-Seq_HEK293_Human	0.80314606
91	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.79149424
92	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.78015292
93	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.76657798
94	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.75930376
95	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.75366793
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.75071070
97	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.73407151
98	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.73043977
99	EWS_26573619_Chip-Seq_HEK293_Human	0.72500404
100	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.70838478

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	5.93463013
2	MP0003123_paternal_imprinting	4.26695679
3	MP0003880_abnormal_central_pattern	3.96968746
4	MP0005423_abnormal_somatic_nervous	3.95263618
5	MP0006276_abnormal_autonomic_nervous	3.30008515
6	MP0001542_abnormal_bone_strength	2.84117016
7	MP0002163_abnormal_gland_morphology	2.82052081
8	MP0003890_abnormal_embryonic-extraembry	2.81725139
9	MP0010368_abnormal_lymphatic_system	2.56459135
10	MP0001188_hyperpigmentation	2.55311970
11	MP0003121_genomic_imprinting	2.53155170
12	MP0000778_abnormal_nervous_system	2.35505611
13	MP0002822_catalepsy	2.34360647
14	MP0008789_abnormal_olfactory_epithelium	2.16520353
15	MP0002184_abnormal_innervation	2.15253542
16	MP0002653_abnormal_ependyma_morphology	2.13756625
17	MP0004185_abnormal_adipocyte_glucose	2.12422696
18	MP0004859_abnormal_synaptic_plasticity	2.08574742
19	MP0000955_abnormal_spinal_cord	2.07844779
20	MP0004145_abnormal_muscle_electrophysio	2.07409933
21	MP0005394_taste/olfaction_phenotype	1.99240264
22	MP0005499_abnormal_olfactory_system	1.99240264
23	MP0005379_endocrine/exocrine_gland_phen	1.91891235
24	MP0002272_abnormal_nervous_system	1.87518508
25	MP0008877_abnormal_DNA_methylation	1.86888030
26	MP0005645_abnormal_hypothalamus_physiol	1.81772555
27	MP0003011_delayed_dark_adaptation	1.72721630
28	MP0003122_maternal_imprinting	1.62737300
29	MP0009046_muscle_twitch	1.58408440
30	MP0006292_abnormal_olfactory_placode	1.50234920
31	MP0002752_abnormal_somatic_nervous	1.49280621
32	MP0004134_abnormal_chest_morphology	1.49049110
33	MP0009379_abnormal_foot_pigmentation	1.46179548
34	MP0002882_abnormal_neuron_morphology	1.43842787
35	MP0002160_abnormal_reproductive_system	1.42615993
36	MP0001529_abnormal_vocalization	1.40866749
37	MP0003635_abnormal_synaptic_transmissio	1.39536748
38	MP0002063_abnormal_learning/memory/cond	1.38490592
39	MP0004742_abnormal_vestibular_system	1.38137355
40	MP0005083_abnormal_biliary_tract	1.35746708
41	MP0001986_abnormal_taste_sensitivity	1.33687371
42	MP0009745_abnormal_behavioral_response	1.33505089
43	MP0001485_abnormal_pinna_reflex	1.33199266
44	MP0002557_abnormal_social/conspecific_i	1.31969755
45	MP0005551_abnormal_eye_electrophysiolog	1.31684031
46	MP0003119_abnormal_digestive_system	1.28579884
47	MP0002572_abnormal_emotion/affect_behav	1.26895178
48	MP0001905_abnormal_dopamine_level	1.26681423
49	MP0004811_abnormal_neuron_physiology	1.25983219
50	MP0002734_abnormal_mechanical_nocicepti	1.22851434
51	MP0001486_abnormal_startle_reflex	1.21076984
52	MP0001984_abnormal_olfaction	1.18246451
53	MP0006072_abnormal_retinal_apoptosis	1.15056079
54	MP0003861_abnormal_nervous_system	1.06320351
55	MP0001970_abnormal_pain_threshold	1.06028159
56	MP0002909_abnormal_adrenal_gland	1.04837311
57	MP0004133_heterotaxia	1.03424048
58	MP0002152_abnormal_brain_morphology	1.03013652
59	MP0004142_abnormal_muscle_tone	1.02474605
60	MP0001286_abnormal_eye_development	1.01338180
61	MP0004270_analgesia	1.00885390
62	MP0002928_abnormal_bile_duct	1.00375463
63	MP0003942_abnormal_urinary_system	1.00162245
64	MP0001440_abnormal_grooming_behavior	0.97783406
65	MP0005220_abnormal_exocrine_pancreas	0.96497207
66	MP0002067_abnormal_sensory_capabilities	0.94587075
67	MP0005195_abnormal_posterior_eye	0.93094042
68	MP0003941_abnormal_skin_development	0.92875825
69	MP0003646_muscle_fatigue	0.92197508
70	MP0002064_seizures	0.90910794
71	MP0002735_abnormal_chemical_nociception	0.90799095
72	MP0000631_abnormal_neuroendocrine_gland	0.90154916
73	MP0001968_abnormal_touch/_nociception	0.88545603
74	MP0005389_reproductive_system_phenotype	0.87442350
75	MP0004885_abnormal_endolymph	0.86433492
76	MP0001879_abnormal_lymphatic_vessel	0.85221128
77	MP0003315_abnormal_perineum_morphology	0.84623482
78	MP0001293_anophthalmia	0.82214681
79	MP0002733_abnormal_thermal_nociception	0.82008073
80	MP0003879_abnormal_hair_cell	0.81794625
81	MP0005084_abnormal_gallbladder_morpholo	0.80466692
82	MP0005448_abnormal_energy_balance	0.79279679
83	MP0005646_abnormal_pituitary_gland	0.76666544
84	MP0002102_abnormal_ear_morphology	0.75380353
85	MP0002233_abnormal_nose_morphology	0.74997631
86	MP0002066_abnormal_motor_capabilities/c	0.74336618
87	MP0009115_abnormal_fat_cell	0.72882293
88	MP0002229_neurodegeneration	0.72259968
89	MP0001502_abnormal_circadian_rhythm	0.71313001
90	MP0002069_abnormal_eating/drinking_beha	0.70102610
91	MP0005377_hearing/vestibular/ear_phenot	0.70065667
92	MP0003878_abnormal_ear_physiology	0.70065667
93	MP0002638_abnormal_pupillary_reflex	0.68673281
94	MP0005253_abnormal_eye_physiology	0.68469210
95	MP0003943_abnormal_hepatobiliary_system	0.68303255
96	MP0000639_abnormal_adrenal_gland	0.68280178
97	MP0000026_abnormal_inner_ear	0.66684728
98	MP0001919_abnormal_reproductive_system	0.64331986
99	MP0002210_abnormal_sex_determination	0.63851878
100	MP0002751_abnormal_autonomic_nervous	0.63025934

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal pancreas size (HP:0012094)	6.95793474
2	Myokymia (HP:0002411)	6.53410708
3	Hepatoblastoma (HP:0002884)	5.22888006
4	Diastasis recti (HP:0001540)	5.09828735
5	Neoplasm of the adrenal cortex (HP:0100641)	4.97686856
6	Neonatal hypoglycemia (HP:0001998)	4.28824580
7	Metaphyseal dysplasia (HP:0100255)	4.07240337
8	Progressive cerebellar ataxia (HP:0002073)	4.02966947
9	Impaired vibration sensation in the lower limbs (HP:0002166)	3.82835303
10	Abnormal hair whorl (HP:0010721)	3.79280187
11	Adrenal hypoplasia (HP:0000835)	3.69779695
12	Medial flaring of the eyebrow (HP:0010747)	3.38884818
13	Limb dystonia (HP:0002451)	3.28961457
14	Anomalous pulmonary venous return (HP:0010772)	3.19494018
15	Gait imbalance (HP:0002141)	3.19468157
16	Molar tooth sign on MRI (HP:0002419)	3.08556686
17	Abnormality of midbrain morphology (HP:0002418)	3.08556686
18	Rib fusion (HP:0000902)	3.01984207
19	Congenital primary aphakia (HP:0007707)	2.96143837
20	Growth hormone deficiency (HP:0000824)	2.94832328
21	Increased hepatocellular lipid droplets (HP:0006565)	2.82993027
22	Nephrogenic diabetes insipidus (HP:0009806)	2.82649908
23	Vaginal atresia (HP:0000148)	2.79848092
24	Abnormality of the pulmonary veins (HP:0011718)	2.76352556
25	Nephronophthisis (HP:0000090)	2.74659366
26	Genital tract atresia (HP:0001827)	2.68737679
27	Abnormality of the labia minora (HP:0012880)	2.68231935
28	Chronic hepatic failure (HP:0100626)	2.61379494
29	Abnormality of the corticospinal tract (HP:0002492)	2.61040153
30	Focal dystonia (HP:0004373)	2.60689233
31	Pendular nystagmus (HP:0012043)	2.60625153
32	Pancreatic fibrosis (HP:0100732)	2.54548532
33	Renal Fanconi syndrome (HP:0001994)	2.49018998
34	Neoplasm of the adrenal gland (HP:0100631)	2.41999893
35	Enlarged kidneys (HP:0000105)	2.38940679
36	Labial hypoplasia (HP:0000066)	2.36439329
37	Osteomalacia (HP:0002749)	2.34644236
38	Lipid accumulation in hepatocytes (HP:0006561)	2.33020609
39	Poor coordination (HP:0002370)	2.32438171
40	Abnormality of the renal medulla (HP:0100957)	2.30514066
41	Polyphagia (HP:0002591)	2.29598382
42	Stenosis of the external auditory canal (HP:0000402)	2.24173057
43	Tubulointerstitial nephritis (HP:0001970)	2.22790207
44	Supranuclear gaze palsy (HP:0000605)	2.19787776
45	Overgrowth (HP:0001548)	2.19411099
46	Acute necrotizing encephalopathy (HP:0006965)	2.18016735
47	Specific learning disability (HP:0001328)	2.16971129
48	True hermaphroditism (HP:0010459)	2.15296310
49	Methylmalonic acidemia (HP:0002912)	2.15187686
50	Chorioretinal atrophy (HP:0000533)	2.15117716
51	Poor suck (HP:0002033)	2.14848385
52	Hypoplastic female external genitalia (HP:0012815)	2.14306917
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12566452
54	Broad-based gait (HP:0002136)	2.11849496
55	Fetal akinesia sequence (HP:0001989)	2.11007840
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.09098669
57	Potter facies (HP:0002009)	2.08922332
58	Facial shape deformation (HP:0011334)	2.08922332
59	Abnormality of renal resorption (HP:0011038)	2.07935875
60	Shawl scrotum (HP:0000049)	2.04802329
61	Anencephaly (HP:0002323)	2.00883326
62	Increased intramyocellular lipid droplets (HP:0012240)	2.00459313
63	Abnormal mitochondria in muscle tissue (HP:0008316)	1.99963025
64	Spastic tetraplegia (HP:0002510)	1.99389561
65	Pancreatic cysts (HP:0001737)	1.99024633
66	Abnormality of cells of the erythroid lineage (HP:0012130)	1.98818239
67	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.98426552
68	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.98426552
69	Drooling (HP:0002307)	1.96716713
70	Tubular atrophy (HP:0000092)	1.96711584
71	Urinary bladder sphincter dysfunction (HP:0002839)	1.95132428
72	Retinitis pigmentosa (HP:0000510)	1.94185955
73	Germ cell neoplasia (HP:0100728)	1.91883796
74	Abolished electroretinogram (ERG) (HP:0000550)	1.89901327
75	Impaired vibratory sensation (HP:0002495)	1.89446473
76	Mitochondrial inheritance (HP:0001427)	1.88036179
77	Cortical dysplasia (HP:0002539)	1.87610903
78	Optic nerve coloboma (HP:0000588)	1.87477789
79	Congenital malformation of the right heart (HP:0011723)	1.87217941
80	Double outlet right ventricle (HP:0001719)	1.87217941
81	Failure to thrive in infancy (HP:0001531)	1.87114610
82	Respiratory difficulties (HP:0002880)	1.86445306
83	Thoracolumbar scoliosis (HP:0002944)	1.83888801
84	Torticollis (HP:0000473)	1.83525133
85	Narrow forehead (HP:0000341)	1.83455689
86	Agitation (HP:0000713)	1.79470849
87	Epiphyseal dysplasia (HP:0002656)	1.78934725
88	Increased CSF lactate (HP:0002490)	1.77840691
89	Partial duplication of thumb phalanx (HP:0009944)	1.77074376
90	Absent eyebrow (HP:0002223)	1.76895273
91	Excessive salivation (HP:0003781)	1.76088558
92	Hyperphosphaturia (HP:0003109)	1.75974382
93	Micropenis (HP:0000054)	1.73374255
94	Prominent occiput (HP:0000269)	1.73311079
95	Long foot (HP:0001833)	1.72417001
96	Incomplete penetrance (HP:0003829)	1.72008122
97	Occipital encephalocele (HP:0002085)	1.70745473
98	Multicystic kidney dysplasia (HP:0000003)	1.70185252
99	Chorioretinal coloboma (HP:0000567)	1.69539834
100	Postaxial hand polydactyly (HP:0001162)	1.67585302

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MINK1	3.70667782
2	NTRK3	3.57382976
3	BMPR1B	2.92971145
4	MARK1	2.78931042
5	DYRK2	2.70864219
6	DYRK3	2.51865808
7	WNK4	2.49375809
8	PIM2	2.30742945
9	MAP3K4	2.30368494
10	PAK3	2.25478622
11	BCR	2.24378309
12	ZAK	2.19810480
13	MAP2K7	2.16731445
14	CASK	2.01964608
15	ARAF	1.94063756
16	WNK3	1.86223804
17	STK16	1.85203110
18	MARK2	1.84806278
19	SIK2	1.83546602
20	DYRK1B	1.77839259
21	PRKCG	1.73987587
22	ICK	1.66933653
23	BRAF	1.65464790
24	CSNK1G2	1.62326007
25	PDK2	1.60007679
26	TAF1	1.52844210
27	NTRK2	1.34510171
28	SGK223	1.33513832
29	SGK494	1.33513832
30	PINK1	1.28986828
31	LIMK1	1.28472914
32	STK24	1.24953640
33	CAMKK1	1.24040857
34	CDK5	1.15565868
35	CAMK1D	1.15233581
36	GRK1	1.15174254
37	MUSK	1.14492113
38	CSNK1G3	1.14097988
39	ADRBK2	1.12139751
40	EPHA4	1.11981609
41	CAMK1G	1.08165166
42	CSNK1A1L	1.06789558
43	MAP2K4	1.04348591
44	TYRO3	1.03272245
45	NUAK1	1.01038117
46	MAP3K9	1.00455430
47	MKNK2	0.99821614
48	SGK2	0.92671817
49	RPS6KA2	0.88763367
50	CDK19	0.87817054
51	MAPK13	0.87415642
52	CSNK1G1	0.86158359
53	STK11	0.85346987
54	CAMKK2	0.84500892
55	SIK3	0.83324071
56	DYRK1A	0.81149748
57	BRSK1	0.77006786
58	CSNK1E	0.76748915
59	PRKCI	0.74078812
60	STK39	0.72994361
61	PRKCH	0.70515746
62	STK3	0.70271073
63	PNCK	0.66174176
64	CAMK1	0.64123788
65	DAPK2	0.62903720
66	DAPK3	0.62769893
67	TNIK	0.62002254
68	MAP3K11	0.61853508
69	TIE1	0.61831189
70	CSNK1A1	0.60495780
71	DMPK	0.59699515
72	AKT3	0.57950277
73	EPHB2	0.57541121
74	RPS6KA6	0.57254701
75	PRKACA	0.53983605
76	RPS6KL1	0.53878140
77	RPS6KC1	0.53878140
78	OXSR1	0.53122143
79	BCKDK	0.50603534
80	MAPK8	0.48809979
81	CDK14	0.48740485
82	PRKCZ	0.47829948
83	MAPK15	0.46907118
84	PRKCE	0.45538210
85	PRKCD	0.45185127
86	PRKCQ	0.44821737
87	MAP3K6	0.44606172
88	MAP4K2	0.44455192
89	PDK1	0.43164025
90	ERBB2	0.40496691
91	AKT1	0.40437132
92	STK38L	0.36737513
93	GRK5	0.36554569
94	PAK1	0.36496884
95	STK38	0.36364995
96	VRK1	0.35634961
97	LATS2	0.34984362
98	PRKG1	0.34733203
99	SGK3	0.33859557
100	RAF1	0.33855734

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.20487932
2	Parkinsons disease_Homo sapiens_hsa05012	3.41263223
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.86898531
4	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.85604358
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.79168728
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.59630862
7	Phototransduction_Homo sapiens_hsa04744	2.52844988
8	Nicotine addiction_Homo sapiens_hsa05033	2.24923003
9	Huntingtons disease_Homo sapiens_hsa05016	2.24222055
10	Alzheimers disease_Homo sapiens_hsa05010	2.20623496
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14381523
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.11782013
13	Ribosome_Homo sapiens_hsa03010	2.10511699
14	Morphine addiction_Homo sapiens_hsa05032	2.03214673
15	Dopaminergic synapse_Homo sapiens_hsa04728	2.01100359
16	GABAergic synapse_Homo sapiens_hsa04727	1.93765993
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88275335
18	Protein export_Homo sapiens_hsa03060	1.87891654
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.82721250
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81964254
21	Long-term depression_Homo sapiens_hsa04730	1.79980715
22	Insulin secretion_Homo sapiens_hsa04911	1.71042558
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.65115382
24	Axon guidance_Homo sapiens_hsa04360	1.60332835
25	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.52034874
26	Circadian entrainment_Homo sapiens_hsa04713	1.38453949
27	Serotonergic synapse_Homo sapiens_hsa04726	1.35038454
28	RNA polymerase_Homo sapiens_hsa03020	1.30547512
29	Sulfur relay system_Homo sapiens_hsa04122	1.29089280
30	Vibrio cholerae infection_Homo sapiens_hsa05110	1.21151261
31	Amphetamine addiction_Homo sapiens_hsa05031	1.20291496
32	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.19054833
33	Cholinergic synapse_Homo sapiens_hsa04725	1.15885194
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10395886
35	Cocaine addiction_Homo sapiens_hsa05030	1.02559235
36	RNA degradation_Homo sapiens_hsa03018	1.01523248
37	Gap junction_Homo sapiens_hsa04540	0.98056649
38	Homologous recombination_Homo sapiens_hsa03440	0.91851573
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.88698032
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87240193
41	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.86633578
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.86507531
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85326062
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84901323
45	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.83299296
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83109363
47	Notch signaling pathway_Homo sapiens_hsa04330	0.82165561
48	Olfactory transduction_Homo sapiens_hsa04740	0.81850913
49	Gastric acid secretion_Homo sapiens_hsa04971	0.80900676
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.80699991
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79936536
52	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.79816294
53	Basal transcription factors_Homo sapiens_hsa03022	0.79434965
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.77787665
55	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.75123922
56	Alcoholism_Homo sapiens_hsa05034	0.73856078
57	Long-term potentiation_Homo sapiens_hsa04720	0.71208622
58	Wnt signaling pathway_Homo sapiens_hsa04310	0.69370596
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68571439
60	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.68562010
61	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.67555024
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66643991
63	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.62942507
64	Taste transduction_Homo sapiens_hsa04742	0.62275709
65	Melanogenesis_Homo sapiens_hsa04916	0.62129355
66	Regulation of autophagy_Homo sapiens_hsa04140	0.60327345
67	Peroxisome_Homo sapiens_hsa04146	0.59817701
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.57117206
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56720459
70	Retinol metabolism_Homo sapiens_hsa00830	0.56139140
71	MAPK signaling pathway_Homo sapiens_hsa04010	0.53875858
72	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.52899459
73	VEGF signaling pathway_Homo sapiens_hsa04370	0.52512509
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.52379572
75	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.52169730
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50945655
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49877060
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45415055
79	Metabolic pathways_Homo sapiens_hsa01100	0.45093408
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44139192
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.43142212
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41576513
83	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41298104
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.41095874
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.41070503
86	Oocyte meiosis_Homo sapiens_hsa04114	0.38730901
87	ErbB signaling pathway_Homo sapiens_hsa04012	0.37487406
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.36695575
89	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36270260
90	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.35665461
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34969533
92	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.34714146
93	Ras signaling pathway_Homo sapiens_hsa04014	0.32969756
94	Salivary secretion_Homo sapiens_hsa04970	0.32722450
95	Tight junction_Homo sapiens_hsa04530	0.32128014
96	Rap1 signaling pathway_Homo sapiens_hsa04015	0.29990216
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.28754166
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27110792
99	Renin secretion_Homo sapiens_hsa04924	0.26976105
100	Choline metabolism in cancer_Homo sapiens_hsa05231	0.26951605

TAC3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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