TAC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.95880976
2somite rostral/caudal axis specification (GO:0032525)6.70940693
3regulation of response to osmotic stress (GO:0047484)6.70160098
4maintenance of protein location in nucleus (GO:0051457)6.60021263
5protein localization to kinetochore (GO:0034501)6.55504289
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.28296824
7regulation of mammary gland epithelial cell proliferation (GO:0033599)6.04314800
8negative regulation of epidermis development (GO:0045683)5.73486970
9negative regulation of cell cycle G2/M phase transition (GO:1902750)5.73268322
10adaptation of signaling pathway (GO:0023058)5.68074888
11muscle organ morphogenesis (GO:0048644)5.65234739
12rRNA transcription (GO:0009303)5.56523993
13regulation of nuclear cell cycle DNA replication (GO:0033262)5.51593921
14histone H4-K8 acetylation (GO:0043982)5.45238064
15histone H4-K5 acetylation (GO:0043981)5.45238064
16histone H4-K12 acetylation (GO:0043983)5.45205909
17regulation of telomere maintenance via telomerase (GO:0032210)5.39496203
18negative regulation of telomerase activity (GO:0051974)5.25411441
19regulation of MHC class I biosynthetic process (GO:0045343)5.17885068
20hormone catabolic process (GO:0042447)4.99948485
21cochlea development (GO:0090102)4.97503344
22negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.94631668
23response to histamine (GO:0034776)4.91745865
24regulation of cilium movement (GO:0003352)4.86556131
25heterochromatin organization (GO:0070828)4.86490996
26cytidine deamination (GO:0009972)4.80812620
27cytidine metabolic process (GO:0046087)4.80812620
28cytidine catabolic process (GO:0006216)4.80812620
29branching involved in mammary gland duct morphogenesis (GO:0060444)4.75317782
30protein localization to chromosome, centromeric region (GO:0071459)4.74999578
31inner ear receptor cell development (GO:0060119)4.72030923
32mitotic sister chromatid segregation (GO:0000070)4.68506735
33flavonoid metabolic process (GO:0009812)4.62731789
34interferon-gamma production (GO:0032609)4.61793359
35negative regulation of epidermal cell differentiation (GO:0045605)4.58822305
36phenol-containing compound catabolic process (GO:0019336)4.47250919
37detection of light stimulus involved in sensory perception (GO:0050962)4.45436343
38detection of light stimulus involved in visual perception (GO:0050908)4.45436343
39NAD biosynthetic process (GO:0009435)4.41512526
40gamma-aminobutyric acid signaling pathway (GO:0007214)4.39667674
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.38040592
42notochord development (GO:0030903)4.33790781
43chromatin assembly (GO:0031497)4.30728356
44rRNA methylation (GO:0031167)4.26368258
45positive regulation of histone deacetylation (GO:0031065)4.25842466
46positive regulation of protein deacetylation (GO:0090312)4.24938162
47regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.24721935
48positive regulation of DNA-dependent DNA replication (GO:2000105)4.24604624
49behavioral response to nicotine (GO:0035095)4.20036724
50histone H4-K16 acetylation (GO:0043984)4.15847771
51regulation of apoptotic process involved in morphogenesis (GO:1902337)4.14298266
52coenzyme catabolic process (GO:0009109)4.14125925
53negative regulation of systemic arterial blood pressure (GO:0003085)4.11250706
54response to dietary excess (GO:0002021)4.09188737
55nuclear pore complex assembly (GO:0051292)4.08579694
56primitive streak formation (GO:0090009)4.06925666
57regulation of germinal center formation (GO:0002634)4.04916881
58nucleoside transmembrane transport (GO:1901642)4.01584054
59sister chromatid segregation (GO:0000819)3.99301668
60protein K11-linked deubiquitination (GO:0035871)3.98112072
61regulation of translation in response to stress (GO:0043555)3.89139425
62vagina development (GO:0060068)3.84924332
63DNA replication-dependent nucleosome organization (GO:0034723)3.84700449
64DNA replication-dependent nucleosome assembly (GO:0006335)3.84700449
65rRNA modification (GO:0000154)3.83133118
66transepithelial transport (GO:0070633)3.82531470
67auditory receptor cell stereocilium organization (GO:0060088)3.81455828
68microtubule severing (GO:0051013)3.80482939
69intracellular estrogen receptor signaling pathway (GO:0030520)3.78354576
70negative regulation of telomere maintenance (GO:0032205)3.75733212
71cellular modified amino acid catabolic process (GO:0042219)3.75552687
72intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.71649488
73indolalkylamine metabolic process (GO:0006586)3.70150982
74female genitalia development (GO:0030540)3.68988244
75response to pheromone (GO:0019236)3.68577227
76icosanoid secretion (GO:0032309)3.67851248
77arachidonic acid secretion (GO:0050482)3.67851248
78DNA replication checkpoint (GO:0000076)3.66243907
79quinone metabolic process (GO:1901661)3.66165836
80positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.65145231
81indole-containing compound catabolic process (GO:0042436)3.64950123
82indolalkylamine catabolic process (GO:0046218)3.64950123
83tryptophan catabolic process (GO:0006569)3.64950123
84maintenance of protein localization in organelle (GO:0072595)3.63775406
85mitochondrion distribution (GO:0048311)3.60922053
86intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.60865621
87protein polyglutamylation (GO:0018095)3.59667152
88RNA stabilization (GO:0043489)3.55533636
89mRNA stabilization (GO:0048255)3.55533636
90vitamin A metabolic process (GO:0006776)3.52300254
91retinoic acid receptor signaling pathway (GO:0048384)3.48115750
92nuclear pore organization (GO:0006999)3.46615148
93bone trabecula formation (GO:0060346)3.45842666
94negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.44985051
95regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.43119328
96cornea development in camera-type eye (GO:0061303)3.41977386
97pyrimidine ribonucleoside catabolic process (GO:0046133)3.41790654
98regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.40754793
99pre-miRNA processing (GO:0031054)3.37273445
100maternal placenta development (GO:0001893)3.36030189
101positive regulation of muscle cell apoptotic process (GO:0010661)3.35851566
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.34951940
103mesenchymal cell differentiation involved in renal system development (GO:2001012)3.34942116
104mesenchymal cell differentiation involved in kidney development (GO:0072161)3.34942116
105cardiovascular system development (GO:0072358)3.32990432
106ventricular system development (GO:0021591)3.32871869
107regulation of cytokine production involved in inflammatory response (GO:1900015)3.31989064
108tryptophan metabolic process (GO:0006568)3.29818541
109fucose catabolic process (GO:0019317)3.28519857
110L-fucose metabolic process (GO:0042354)3.28519857
111L-fucose catabolic process (GO:0042355)3.28519857
112neural tube formation (GO:0001841)3.28296575
113reflex (GO:0060004)3.26154850
114regulation of telomere maintenance (GO:0032204)3.25890895
115intestinal epithelial cell development (GO:0060576)3.25667269
116pyridine nucleotide biosynthetic process (GO:0019363)3.25189675
117nicotinamide nucleotide biosynthetic process (GO:0019359)3.25189675
118negative regulation of interleukin-2 production (GO:0032703)3.24704169
119epoxygenase P450 pathway (GO:0019373)3.24454121
120negative regulation of smooth muscle cell differentiation (GO:0051151)3.22718171
121negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.21205168
122detection of mechanical stimulus involved in sensory perception (GO:0050974)3.20612452
123apoptotic DNA fragmentation (GO:0006309)3.17647562
124cell differentiation involved in metanephros development (GO:0072202)3.17485899
125adrenergic receptor signaling pathway (GO:0071875)3.16648255
126inner ear receptor stereocilium organization (GO:0060122)3.14272491
127establishment of endothelial barrier (GO:0061028)3.13960703
128cellular response to ammonium ion (GO:0071242)3.13792157
129trophectodermal cell differentiation (GO:0001829)3.13754557
130kynurenine metabolic process (GO:0070189)3.12399532
131regulation of telomerase activity (GO:0051972)3.11391229
132proline transport (GO:0015824)3.10156869
133snRNA processing (GO:0016180)3.08788295
134pore complex assembly (GO:0046931)3.08631720
135establishment of protein localization to Golgi (GO:0072600)3.08143921
136photoreceptor cell maintenance (GO:0045494)3.07500513
137innervation (GO:0060384)3.06093582
138cofactor transport (GO:0051181)3.05393488
139cell fate commitment involved in formation of primary germ layer (GO:0060795)3.05264636
140regulation of rhodopsin mediated signaling pathway (GO:0022400)3.05210251
141righting reflex (GO:0060013)3.04760794
142rhodopsin mediated signaling pathway (GO:0016056)3.03390638
143DNA duplex unwinding (GO:0032508)3.03038207
144regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.00935489
145* tachykinin receptor signaling pathway (GO:0007217)2.98084068
146DNA geometric change (GO:0032392)2.97623104
147brain morphogenesis (GO:0048854)2.97383973
148regulation of hippo signaling (GO:0035330)2.96779476
149regulation of timing of cell differentiation (GO:0048505)2.95384341
150piRNA metabolic process (GO:0034587)2.94023536
151indole-containing compound metabolic process (GO:0042430)2.93058708
152negative regulation of astrocyte differentiation (GO:0048712)2.91365904
153L-methionine salvage (GO:0071267)2.90828200
154L-methionine biosynthetic process (GO:0071265)2.90828200
155amino acid salvage (GO:0043102)2.90828200
156negative regulation of multicellular organism growth (GO:0040015)2.89674371
157positive regulation of guanylate cyclase activity (GO:0031284)2.81500481
158embryonic epithelial tube formation (GO:0001838)2.78238176
159regulation of interferon-gamma biosynthetic process (GO:0045072)2.72855149
160cAMP catabolic process (GO:0006198)2.72319488
161axoneme assembly (GO:0035082)2.69831800
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68632681
163primary amino compound metabolic process (GO:1901160)2.64185029
164serotonin metabolic process (GO:0042428)2.63498648
165negative regulation of mast cell activation (GO:0033004)2.62221942
166cilium or flagellum-dependent cell motility (GO:0001539)2.60431193
167gamma-aminobutyric acid transport (GO:0015812)2.59265535
168central nervous system projection neuron axonogenesis (GO:0021952)2.58952109
169DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.58571304
170central nervous system neuron axonogenesis (GO:0021955)2.57339494
171nephron tubule formation (GO:0072079)2.56159109
172cellular response to exogenous dsRNA (GO:0071360)2.55120934
173epithelial tube formation (GO:0072175)2.54078638
174regulation of meiosis I (GO:0060631)2.53573925
175mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.53563499
176ADP metabolic process (GO:0046031)2.53280174
177regulation of development, heterochronic (GO:0040034)2.52535259
178ncRNA 3-end processing (GO:0043628)2.51680133
179L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51368880
180behavioral response to ethanol (GO:0048149)2.49690709
181positive regulation of mast cell degranulation (GO:0043306)2.49014875
182positive regulation of mast cell activation involved in immune response (GO:0033008)2.49014875
183visual perception (GO:0007601)2.47553858
184regulation of guanylate cyclase activity (GO:0031282)2.47547110
185sensory perception of light stimulus (GO:0050953)2.46791384
186negative regulation of metanephros development (GO:0072217)2.46567573
187rRNA catabolic process (GO:0016075)2.46149213
188sulfation (GO:0051923)2.44404737
189negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.44048021
190snRNA metabolic process (GO:0016073)2.43751838
191negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43378433
192cyclic nucleotide catabolic process (GO:0009214)2.42289914
193DNA integration (GO:0015074)2.41942465
194multicellular organism reproduction (GO:0032504)2.41758523
195negative regulation of reactive oxygen species metabolic process (GO:2000378)2.39407449
196daunorubicin metabolic process (GO:0044597)10.8451949
197polyketide metabolic process (GO:0030638)10.8451949
198doxorubicin metabolic process (GO:0044598)10.8451949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.70001093
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.08547271
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.08547271
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.08547271
5E2F7_22180533_ChIP-Seq_HELA_Human4.68376840
6EZH2_22144423_ChIP-Seq_EOC_Human4.51208433
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.79673308
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.53245116
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.16054710
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.10727862
11GBX2_23144817_ChIP-Seq_PC3_Human3.00458233
12ZNF274_21170338_ChIP-Seq_K562_Hela2.91381879
13VDR_22108803_ChIP-Seq_LS180_Human2.87282433
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85007502
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68110570
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.66408315
17IGF1R_20145208_ChIP-Seq_DFB_Human2.58160798
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.56111095
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.47759005
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38745685
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.36349333
22* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.30406425
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24833253
24TCF3_18692474_ChIP-Seq_MEFs_Mouse2.18981403
25MYC_22102868_ChIP-Seq_BL_Human2.15744181
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10122349
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07934194
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.05840352
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05088453
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04868509
31BCAT_22108803_ChIP-Seq_LS180_Human2.01917579
32P300_19829295_ChIP-Seq_ESCs_Human2.01897198
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00152088
34TAF15_26573619_Chip-Seq_HEK293_Human1.99042785
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97729959
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96791867
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93866592
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.93224550
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91625365
40* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.91349974
41ER_23166858_ChIP-Seq_MCF-7_Human1.89929065
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86749848
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86146665
44STAT3_23295773_ChIP-Seq_U87_Human1.84619217
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81911360
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.80479979
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.78985160
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78132504
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74865586
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73533990
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73491028
52* TCF4_23295773_ChIP-Seq_U87_Human1.72205772
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68927193
54CBP_20019798_ChIP-Seq_JUKART_Human1.68927193
55SMAD4_21799915_ChIP-Seq_A2780_Human1.68575669
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68361265
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65804131
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65804131
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65739751
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65103462
61IRF1_19129219_ChIP-ChIP_H3396_Human1.61490302
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61289473
63TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.61135410
64EWS_26573619_Chip-Seq_HEK293_Human1.58599278
65AR_21572438_ChIP-Seq_LNCaP_Human1.57981103
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.57246007
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55063311
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52853389
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.52329207
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50914745
71FUS_26573619_Chip-Seq_HEK293_Human1.50813601
72* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48052981
73* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46063525
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.45368508
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44218753
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42586633
77* TCF7_22412390_ChIP-Seq_EML_Mouse1.40997838
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.39513020
79TCF4_22108803_ChIP-Seq_LS180_Human1.39237019
80AR_25329375_ChIP-Seq_VCAP_Human1.37992242
81E2F1_17053090_ChIP-ChIP_MCF-7_Human1.36687400
82* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35441956
83* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34704039
84* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.33583622
85RUNX2_22187159_ChIP-Seq_PCA_Human1.33330413
86* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.32931681
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31738861
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31715689
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29714022
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29455820
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29236141
92SOX2_19829295_ChIP-Seq_ESCs_Human1.29105894
93NANOG_19829295_ChIP-Seq_ESCs_Human1.29105894
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27671005
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27608123
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27402540
97RNF2_27304074_Chip-Seq_NSC_Mouse1.27348501
98SCL_19346495_ChIP-Seq_HPC-7_Human1.26611551
99NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26558866
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.26125728
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25769228
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25533644
103CDX2_22108803_ChIP-Seq_LS180_Human1.24675226
104* FLI1_21867929_ChIP-Seq_TH2_Mouse1.24096613
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24059056
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23858813
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22399987
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.21755892
109* REST_21632747_ChIP-Seq_MESCs_Mouse1.21242346
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21002920
111DROSHA_22980978_ChIP-Seq_HELA_Human1.20950174
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20225480
113OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19818780
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.19625889
115SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19459705
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19092868
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19012327
118NCOR1_26117541_ChIP-Seq_K562_Human1.18132505
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18126353
120KDM2B_26808549_Chip-Seq_REH_Human1.17794011
121NOTCH1_21737748_ChIP-Seq_TLL_Human1.17212768
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16384048
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15877602
124TP53_22127205_ChIP-Seq_IMR90_Human1.15794547
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14723420
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14320853
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14221439
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.14058244
129TP53_22573176_ChIP-Seq_HFKS_Human1.13147407
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12647819
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.12630186
132* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12478227
133MYC_18555785_ChIP-Seq_MESCs_Mouse1.11905287
134* CDX2_20551321_ChIP-Seq_CACO-2_Human1.11484041
135ELK3_25401928_ChIP-Seq_HUVEC_Human1.11394552
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.10893691
137VDR_24787735_ChIP-Seq_THP-1_Human1.10822853
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10333752
139RXR_22108803_ChIP-Seq_LS180_Human1.09249379
140MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06539825
141SOX2_21211035_ChIP-Seq_LN229_Gbm1.05901076
142EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05738630
143* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04702054
144YY1_21170310_ChIP-Seq_MESCs_Mouse1.04555092
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04424081
146EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03971598
147SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03610925
148E2F1_18555785_Chip-Seq_ESCs_Mouse1.03594478
149* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03496139
150P53_22387025_ChIP-Seq_ESCs_Mouse1.03421965
151* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03288141
152FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02577481
153FOXA1_25329375_ChIP-Seq_VCAP_Human1.01084934
154FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01084934
155TP53_16413492_ChIP-PET_HCT116_Human1.00023117
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99821239
157NANOG_16518401_ChIP-PET_MESCs_Mouse0.99247973
158SMC4_20622854_ChIP-Seq_HELA_Human0.98997284
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.98902069
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98785175
161SMAD_19615063_ChIP-ChIP_OVARY_Human0.98113759
162SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97955194
163AHR_22903824_ChIP-Seq_MCF-7_Human0.96687707
164IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96083117
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.95014270
166LXR_22292898_ChIP-Seq_THP-1_Human0.94864715
167CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94529223
168PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93765578
169RACK7_27058665_Chip-Seq_MCF-7_Human0.93510235
170POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93471483
171MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91333747
172TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90453735
173CTCF_21964334_Chip-Seq_Bcells_Human0.90116927
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89406960
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.88640585
176NANOG_16153702_ChIP-ChIP_HESCs_Human0.88612631
177POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88067937
178* KDM2B_26808549_Chip-Seq_K562_Human0.86827056
179STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84706712
180EGR1_19374776_ChIP-ChIP_THP-1_Human0.84014699
181WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83374037
182E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82777970
183FOXO3_23340844_ChIP-Seq_DLD1_Human0.81674304
184KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80770904
185P68_20966046_ChIP-Seq_HELA_Human0.80137888
186SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.79157876
187VDR_21846776_ChIP-Seq_THP-1_Human0.76677214
188KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76329772
189TBX3_20139965_ChIP-Seq_ESCs_Mouse0.76040832
190TBX3_20139965_ChIP-Seq_MESCs_Mouse0.74565483
191KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74501273
192KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.74304152
193KAP1_27257070_Chip-Seq_ESCs_Mouse0.74155297
194* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.74149340
195YY1_22570637_ChIP-Seq_MALME-3M_Human0.73705034
196CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72640431
197ESR2_21235772_ChIP-Seq_MCF-7_Human0.70873087
198BCOR_27268052_Chip-Seq_Bcells_Human0.70035968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.98995535
2MP0002254_reproductive_system_inflammat4.87454871
3MP0004264_abnormal_extraembryonic_tissu4.42974374
4MP0003011_delayed_dark_adaptation4.33377369
5MP0005394_taste/olfaction_phenotype4.14509629
6MP0005499_abnormal_olfactory_system4.14509629
7MP0006292_abnormal_olfactory_placode3.87412360
8MP0000569_abnormal_digit_pigmentation3.56237648
9MP0001501_abnormal_sleep_pattern3.49769037
10MP0000372_irregular_coat_pigmentation3.33772702
11MP0003890_abnormal_embryonic-extraembry3.14258768
12MP0005075_abnormal_melanosome_morpholog3.13702217
13MP0008057_abnormal_DNA_replication3.06972191
14MP0003646_muscle_fatigue3.06850956
15MP0005551_abnormal_eye_electrophysiolog2.91794650
16MP0004858_abnormal_nervous_system2.82235166
17MP0002332_abnormal_exercise_endurance2.81119011
18MP0003705_abnormal_hypodermis_morpholog2.63207500
19MP0003122_maternal_imprinting2.55898623
20MP0004957_abnormal_blastocyst_morpholog2.42107520
21MP0006276_abnormal_autonomic_nervous2.35879770
22MP0008872_abnormal_physiological_respon2.34376762
23MP0001968_abnormal_touch/_nociception2.28507697
24MP0010352_gastrointestinal_tract_polyps2.27846955
25MP0008877_abnormal_DNA_methylation2.14553152
26MP0005645_abnormal_hypothalamus_physiol2.13802762
27MP0005257_abnormal_intraocular_pressure2.10910860
28MP0003121_genomic_imprinting2.10861648
29MP0002735_abnormal_chemical_nociception2.08101448
30MP0002736_abnormal_nociception_after1.99499878
31MP0002653_abnormal_ependyma_morphology1.99257019
32MP0008789_abnormal_olfactory_epithelium1.99251854
33MP0006082_CNS_inflammation1.95739873
34MP0005253_abnormal_eye_physiology1.94133565
35MP0008961_abnormal_basal_metabolism1.92359900
36MP0006035_abnormal_mitochondrial_morpho1.89384340
37MP0003183_abnormal_peptide_metabolism1.82614718
38MP0010386_abnormal_urinary_bladder1.82349328
39MP0002638_abnormal_pupillary_reflex1.78759871
40MP0009745_abnormal_behavioral_response1.78713951
41MP0005646_abnormal_pituitary_gland1.76673656
42MP0002396_abnormal_hematopoietic_system1.75158473
43MP0001672_abnormal_embryogenesis/_devel1.71676160
44MP0005380_embryogenesis_phenotype1.71676160
45MP0005671_abnormal_response_to1.68366029
46MP0010030_abnormal_orbit_morphology1.67649073
47MP0002088_abnormal_embryonic_growth/wei1.66120140
48MP0003984_embryonic_growth_retardation1.63892606
49MP0002102_abnormal_ear_morphology1.62446768
50MP0003938_abnormal_ear_development1.62326913
51MP0005174_abnormal_tail_pigmentation1.61971260
52MP0000678_abnormal_parathyroid_gland1.59874202
53MP0009046_muscle_twitch1.52783020
54MP0002733_abnormal_thermal_nociception1.52683538
55MP0003136_yellow_coat_color1.51084857
56MP0002138_abnormal_hepatobiliary_system1.49745074
57MP0001849_ear_inflammation1.49546084
58MP0001324_abnormal_eye_pigmentation1.48144825
59MP0001348_abnormal_lacrimal_gland1.44410037
60MP0001970_abnormal_pain_threshold1.42427649
61MP0002277_abnormal_respiratory_mucosa1.42079996
62MP0002233_abnormal_nose_morphology1.41057904
63MP0002932_abnormal_joint_morphology1.41018566
64MP0002127_abnormal_cardiovascular_syste1.40507790
65MP0001486_abnormal_startle_reflex1.40312815
66MP0005377_hearing/vestibular/ear_phenot1.38362994
67MP0003878_abnormal_ear_physiology1.38362994
68MP0005647_abnormal_sex_gland1.36304785
69MP0000350_abnormal_cell_proliferation1.35978816
70MP0002092_abnormal_eye_morphology1.34327111
71MP0002928_abnormal_bile_duct1.32947673
72MP0001986_abnormal_taste_sensitivity1.32806807
73MP0004043_abnormal_pH_regulation1.32281561
74MP0001293_anophthalmia1.31077977
75MP0000015_abnormal_ear_pigmentation1.27909242
76MP0005266_abnormal_metabolism1.25747812
77MP0002572_abnormal_emotion/affect_behav1.24625178
78MP0000762_abnormal_tongue_morphology1.24609551
79MP0002970_abnormal_white_adipose1.23307553
80MP0001984_abnormal_olfaction1.23272599
81MP0003123_paternal_imprinting1.22883000
82MP0003635_abnormal_synaptic_transmissio1.22559507
83MP0000427_abnormal_hair_cycle1.22189903
84MP0002086_abnormal_extraembryonic_tissu1.16938031
85MP0004484_altered_response_of1.16669148
86MP0002184_abnormal_innervation1.15681217
87MP0004142_abnormal_muscle_tone1.14253561
88MP0001835_abnormal_antigen_presentation1.13709058
89MP0002085_abnormal_embryonic_tissue1.12262249
90MP0002067_abnormal_sensory_capabilities1.11919127
91MP0003077_abnormal_cell_cycle1.11398979
92MP0000026_abnormal_inner_ear1.10498371
93MP0004147_increased_porphyrin_level1.09847006
94MP0005167_abnormal_blood-brain_barrier1.09656255
95MP0002272_abnormal_nervous_system1.08856620
96MP0001963_abnormal_hearing_physiology1.08835841
97MP0003718_maternal_effect1.06938283
98MP0003880_abnormal_central_pattern1.06331609
99MP0000750_abnormal_muscle_regeneration1.06209009
100MP0002114_abnormal_axial_skeleton1.05033582
101MP0004885_abnormal_endolymph1.04818856
102MP0002876_abnormal_thyroid_physiology1.04358008
103MP0002168_other_aberrant_phenotype1.02009262
104MP0000049_abnormal_middle_ear0.99903764
105MP0000631_abnormal_neuroendocrine_gland0.99669704
106MP0002229_neurodegeneration0.99277765
107MP0003943_abnormal_hepatobiliary_system0.99222519
108MP0002163_abnormal_gland_morphology0.98976893
109MP0001440_abnormal_grooming_behavior0.98581263
110MP0000230_abnormal_systemic_arterial0.98556192
111MP0001800_abnormal_humoral_immune0.96890252
112MP0004197_abnormal_fetal_growth/weight/0.95585361
113MP0000371_diluted_coat_color0.95544148
114MP0002909_abnormal_adrenal_gland0.94777611
115MP0001485_abnormal_pinna_reflex0.94684705
116MP0008770_decreased_survivor_rate0.94462330
117MP0005623_abnormal_meninges_morphology0.94073724
118MP0003935_abnormal_craniofacial_develop0.93789281
119MP0002084_abnormal_developmental_patter0.93443628
120MP0002557_abnormal_social/conspecific_i0.92761989
121MP0000432_abnormal_head_morphology0.92584715
122MP0006072_abnormal_retinal_apoptosis0.91952273
123MP0004742_abnormal_vestibular_system0.91894916
124MP0004381_abnormal_hair_follicle0.90481660
125MP0000749_muscle_degeneration0.90162203
126MP0002132_abnormal_respiratory_system0.89352581
127MP0002095_abnormal_skin_pigmentation0.89030939
128MP0005171_absent_coat_pigmentation0.88155089
129MP0002752_abnormal_somatic_nervous0.87881683
130MP0001764_abnormal_homeostasis0.86866048
131MP0003787_abnormal_imprinting0.86672913
132MP0009703_decreased_birth_body0.86655917
133MP0000428_abnormal_craniofacial_morphol0.86591180
134MP0003137_abnormal_impulse_conducting0.86038347
135MP0002063_abnormal_learning/memory/cond0.85891669
136MP0002064_seizures0.84820473
137MP0000778_abnormal_nervous_system0.84633899
138MP0005395_other_phenotype0.83303786
139MP0000490_abnormal_crypts_of0.83049965
140MP0003950_abnormal_plasma_membrane0.82962003
141MP0002734_abnormal_mechanical_nocicepti0.82875006
142MP0000538_abnormal_urinary_bladder0.82538844
143MP0000313_abnormal_cell_death0.82343652
144MP0003698_abnormal_male_reproductive0.80920149
145MP0003045_fibrosis0.80836804
146MP0005195_abnormal_posterior_eye0.80428881
147MP0002090_abnormal_vision0.80391007
148MP0000383_abnormal_hair_follicle0.79100310
149MP0004883_abnormal_blood_vessel0.78823549
150MP0004145_abnormal_muscle_electrophysio0.78494448
151MP0002693_abnormal_pancreas_physiology0.77962039
152MP0003755_abnormal_palate_morphology0.77579952
153MP0003763_abnormal_thymus_physiology0.77360271
154MP0002925_abnormal_cardiovascular_devel0.77322871
155MP0005084_abnormal_gallbladder_morpholo0.76684596
156MP0003786_premature_aging0.75375246
157MP0003111_abnormal_nucleus_morphology0.74005490
158MP0001730_embryonic_growth_arrest0.73891949
159MP0005410_abnormal_fertilization0.73398118
160MP0009780_abnormal_chondrocyte_physiolo0.72603573
161MP0002751_abnormal_autonomic_nervous0.72065467
162MP0005023_abnormal_wound_healing0.71962843
163MP0001119_abnormal_female_reproductive0.71929435
164MP0005508_abnormal_skeleton_morphology0.71289958
165MP0002098_abnormal_vibrissa_morphology0.71289159
166MP0002080_prenatal_lethality0.70561220
167MP0005391_vision/eye_phenotype0.70429139
168MP0002938_white_spotting0.70370867
169MP0004924_abnormal_behavior0.69975035
170MP0005386_behavior/neurological_phenoty0.69975035
171MP0005248_abnormal_Harderian_gland0.67579205
172MP0002269_muscular_atrophy0.66775482
173MP0000377_abnormal_hair_follicle0.66580175
174MP0010678_abnormal_skin_adnexa0.65934520
175MP0001697_abnormal_embryo_size0.65795231
176MP0003119_abnormal_digestive_system0.64795784
177MP0010094_abnormal_chromosome_stability0.63921936
178MP0002796_impaired_skin_barrier0.60992109
179MP0009115_abnormal_fat_cell0.59772635
180MP0002019_abnormal_tumor_incidence0.58911173
181MP0002116_abnormal_craniofacial_bone0.58448374
182MP0005310_abnormal_salivary_gland0.58018969
183MP0004133_heterotaxia0.57016414
184MP0002722_abnormal_immune_system0.55852875
185MP0002405_respiratory_system_inflammati0.55423844
186MP0001727_abnormal_embryo_implantation0.53402558
187MP0000689_abnormal_spleen_morphology0.52713213
188MP0005197_abnormal_uvea_morphology0.51701873

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.31488782
2Hypochromic microcytic anemia (HP:0004840)6.24997766
3Abnormality of macular pigmentation (HP:0008002)6.03433838
4Decreased central vision (HP:0007663)5.34788687
5Multiple enchondromatosis (HP:0005701)5.22283150
6Abnormality of the lower motor neuron (HP:0002366)5.11741757
7Hepatoblastoma (HP:0002884)5.09970027
8Rib fusion (HP:0000902)5.02679528
9Attenuation of retinal blood vessels (HP:0007843)4.57987373
10Ependymoma (HP:0002888)4.38161998
11Neoplasm of striated muscle (HP:0009728)4.24766728
12Pancreatic cysts (HP:0001737)4.13656807
13Rhabdomyosarcoma (HP:0002859)4.06301086
14Decreased electroretinogram (ERG) amplitude (HP:0000654)3.94421843
15True hermaphroditism (HP:0010459)3.84796180
16Congenital stationary night blindness (HP:0007642)3.66484132
17Pancreatic fibrosis (HP:0100732)3.66320024
18Poikiloderma (HP:0001029)3.62796841
19Testicular atrophy (HP:0000029)3.44770258
20Macular degeneration (HP:0000608)3.38931790
21Partial duplication of thumb phalanx (HP:0009944)3.36809833
22Nephroblastoma (Wilms tumor) (HP:0002667)3.32070225
23Horizontal nystagmus (HP:0000666)3.30236667
24Pendular nystagmus (HP:0012043)3.26955162
25Chronic hepatic failure (HP:0100626)3.25529892
26Bifid tongue (HP:0010297)3.20771387
27Fused cervical vertebrae (HP:0002949)3.19369532
28Constricted visual fields (HP:0001133)3.17185697
29Nephronophthisis (HP:0000090)3.14511833
30Rectovaginal fistula (HP:0000143)3.14484918
31Rectal fistula (HP:0100590)3.14484918
32Astrocytoma (HP:0009592)3.10686362
33Abnormality of the astrocytes (HP:0100707)3.10686362
34Abnormality of the salivary glands (HP:0010286)3.09448324
35Trismus (HP:0000211)3.08478023
36Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06820550
37Dyschromatopsia (HP:0007641)3.06518669
38Embryonal renal neoplasm (HP:0011794)3.06424856
39Progressive cerebellar ataxia (HP:0002073)3.04660433
40Abnormality of midbrain morphology (HP:0002418)3.03406785
41Molar tooth sign on MRI (HP:0002419)3.03406785
42Gaze-evoked nystagmus (HP:0000640)3.01181862
43Anomalous pulmonary venous return (HP:0010772)3.00548274
44Chorioretinal atrophy (HP:0000533)2.98807493
45Vaginal fistula (HP:0004320)2.96078722
46Intestinal fistula (HP:0100819)2.95965293
47Hypochromic anemia (HP:0001931)2.95034000
48Ragged-red muscle fibers (HP:0003200)2.92030625
49Amyotrophic lateral sclerosis (HP:0007354)2.90997263
50Partial duplication of the phalanx of hand (HP:0009999)2.90481644
51IgG deficiency (HP:0004315)2.88694098
52Abolished electroretinogram (ERG) (HP:0000550)2.87803638
53Hypoplasia of the fovea (HP:0007750)2.83522060
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.83522060
55Hyperinsulinemic hypoglycemia (HP:0000825)2.80110190
56Preauricular skin tag (HP:0000384)2.77336838
57Congenital sensorineural hearing impairment (HP:0008527)2.77302311
58Abnormality of the renal medulla (HP:0100957)2.77076819
59Abnormality of the renal cortex (HP:0011035)2.76496028
60Abnormal cartilage morphology (HP:0002763)2.75368299
61Genetic anticipation (HP:0003743)2.75214164
62Nasal polyposis (HP:0100582)2.73391151
63Medial flaring of the eyebrow (HP:0010747)2.73190510
64Progressive inability to walk (HP:0002505)2.70796842
65Generalized hypotonia (HP:0001290)2.69413507
66Episodic fever (HP:0001954)2.67066813
67Genital tract atresia (HP:0001827)2.65066058
68Abnormal lung lobation (HP:0002101)2.64673520
69Aplasia/hypoplasia of the humerus (HP:0006507)2.61244192
70Chromsome breakage (HP:0040012)2.59066343
71Short humerus (HP:0005792)2.57096642
72Abnormality of the pulmonary veins (HP:0011718)2.56133832
73Recurrent sinusitis (HP:0011108)2.55965972
74Recurrent pneumonia (HP:0006532)2.55961965
75Neoplasm of the heart (HP:0100544)2.55951702
76Periauricular skin pits (HP:0100277)2.53268354
77Preauricular pit (HP:0004467)2.53268354
78Focal motor seizures (HP:0011153)2.52889589
79Skin tags (HP:0010609)2.52749535
80Vaginal atresia (HP:0000148)2.50906560
81Type II lissencephaly (HP:0007260)2.50824940
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.49444757
83Difficulty running (HP:0009046)2.49209116
84Abnormality of chromosome segregation (HP:0002916)2.48851251
85Short 5th finger (HP:0009237)2.46465065
86Cystic liver disease (HP:0006706)2.46035424
87Sensory axonal neuropathy (HP:0003390)2.44872740
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44852089
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.44672433
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44628935
91Abnormal rod and cone electroretinograms (HP:0008323)2.44474703
92Progressive muscle weakness (HP:0003323)2.44453713
93Villous atrophy (HP:0011473)2.42262994
94Abnormality of small intestinal villus morphology (HP:0011472)2.42262994
95Impulsivity (HP:0100710)2.41881130
96Decreased circulating renin level (HP:0003351)2.41561069
97Large earlobe (HP:0009748)2.38278862
98Hypophosphatemic rickets (HP:0004912)2.38232921
99Increased connective tissue (HP:0009025)2.36711932
100Bony spicule pigmentary retinopathy (HP:0007737)2.35335767
101Gait imbalance (HP:0002141)2.34918305
102Abnormality of the phalanges of the hallux (HP:0010057)2.33352194
103Reduced antithrombin III activity (HP:0001976)2.32283529
104Congenital primary aphakia (HP:0007707)2.27428471
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.27138476
106Abnormality of the nasal mucosa (HP:0000433)2.22873481
107Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.22324445
108Focal seizures (HP:0007359)2.22124521
109Abnormality of the distal phalanx of the thumb (HP:0009617)2.21967026
110Febrile seizures (HP:0002373)2.21338495
111Shawl scrotum (HP:0000049)2.21115104
112Keratoconus (HP:0000563)2.20324744
113Increased corneal curvature (HP:0100692)2.20324744
114Glioma (HP:0009733)2.20132381
115Hypopigmentation of the fundus (HP:0007894)2.20130823
116Tongue fasciculations (HP:0001308)2.20073636
117Anhidrosis (HP:0000970)2.20031179
118Renal duplication (HP:0000075)2.19332378
119Nephrogenic diabetes insipidus (HP:0009806)2.18574382
120Facial shape deformation (HP:0011334)2.18096347
121Potter facies (HP:0002009)2.18096347
122Hyperventilation (HP:0002883)2.16559971
123Nasolacrimal duct obstruction (HP:0000579)2.15794709
124Polydipsia (HP:0001959)2.14491145
125Abnormal drinking behavior (HP:0030082)2.14491145
126Tetraplegia (HP:0002445)2.14439600
127Pseudobulbar signs (HP:0002200)2.14080514
128Abnormality of the pubic bones (HP:0003172)2.13224364
129Cerebellar dysplasia (HP:0007033)2.13160367
130Inability to walk (HP:0002540)2.11934319
131Cheilitis (HP:0100825)2.11096470
132Vertebral fusion (HP:0002948)2.09348660
133Microretrognathia (HP:0000308)2.08444218
134Skin pits (HP:0100276)2.08405389
135Abnormality of the fovea (HP:0000493)2.07793612
136Abnormal biliary tract physiology (HP:0012439)2.07592037
137Bile duct proliferation (HP:0001408)2.07592037
138Congenital hepatic fibrosis (HP:0002612)2.06874222
139Tubular atrophy (HP:0000092)2.06530613
140Fair hair (HP:0002286)2.06132969
141Renal cortical cysts (HP:0000803)2.05855839
142Choroideremia (HP:0001139)2.04986170
143Muscle fibrillation (HP:0010546)2.04943148
144Adenoma sebaceum (HP:0009720)2.04492304
145Angiofibromas (HP:0010615)2.04492304
146Abnormality of the musculature of the hand (HP:0001421)2.03954401
147Mildly elevated creatine phosphokinase (HP:0008180)2.03924781
148Combined immunodeficiency (HP:0005387)2.03013607
149Bicornuate uterus (HP:0000813)2.00778163
150Dialeptic seizures (HP:0011146)1.99284600
151Upper motor neuron abnormality (HP:0002127)1.98880700
152Upper limb muscle weakness (HP:0003484)1.98256900
153EMG: neuropathic changes (HP:0003445)1.97130167
154Achilles tendon contracture (HP:0001771)1.96862402
155Postaxial foot polydactyly (HP:0001830)1.96547931
156Glossoptosis (HP:0000162)1.94377733
157Malignant neoplasm of the central nervous system (HP:0100836)1.92691224
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.92510916
159Generalized hypopigmentation of hair (HP:0011358)1.90996293
160Resting tremor (HP:0002322)1.90113166
161Anencephaly (HP:0002323)1.89707238
162Premature graying of hair (HP:0002216)1.89537721
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89174092
164Abnormality of alanine metabolism (HP:0010916)1.89174092
165Hyperalaninemia (HP:0003348)1.89174092
166Prominent occiput (HP:0000269)1.88321229
167Meckel diverticulum (HP:0002245)1.87577409
168Thyroiditis (HP:0100646)1.87455953
169Abnormality of the intrinsic pathway (HP:0010989)1.87228829
170Fasciculations (HP:0002380)1.87107462
171Hand muscle atrophy (HP:0009130)1.86559383
172Amblyopia (HP:0000646)1.86447486
173Malnutrition (HP:0004395)1.86221475
174Sclerocornea (HP:0000647)1.86183630
175Poor coordination (HP:0002370)1.85686650
176Photophobia (HP:0000613)1.85049034
177Stomatitis (HP:0010280)1.84280604
178Type II diabetes mellitus (HP:0005978)1.84153762
179Absent speech (HP:0001344)1.83224411
180Clumsiness (HP:0002312)1.82778646
181Retinitis pigmentosa (HP:0000510)1.80598813
182Aplasia/Hypoplasia of the lens (HP:0008063)1.80121759
183Stomach cancer (HP:0012126)1.78804027
184Protruding tongue (HP:0010808)1.77894486
185Broad-based gait (HP:0002136)1.76778424
186Lissencephaly (HP:0001339)1.76093024
187Furrowed tongue (HP:0000221)1.75573889
188Polyuria (HP:0000103)1.75409955
189Abnormality of dental color (HP:0011073)1.74902033
190Autoamputation (HP:0001218)1.73979384
191Male pseudohermaphroditism (HP:0000037)1.73926072
192Hip dysplasia (HP:0001385)1.73418666
193Abnormality of B cell number (HP:0010975)1.69681659
194Abnormality of the labia minora (HP:0012880)1.69415675
195Short foot (HP:0001773)1.69400832
196Astigmatism (HP:0000483)1.68821298
197Pigmentary retinal degeneration (HP:0001146)1.65142444
198Widely spaced teeth (HP:0000687)1.64348209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.57695442
2FRK7.41719860
3GRK55.27438518
4ERN15.10329387
5GRK64.69130009
6ADRBK23.67244985
7TAOK33.40588893
8GRK13.19680277
9CSF1R3.09946692
10TYRO32.70257579
11NEK62.62917629
12MAP4K22.54934744
13TGFBR22.52419059
14BMPR1B2.46679769
15MATK2.45208808
16TTK2.43850823
17STK102.35945116
18MAP3K42.35528457
19WNK32.33518709
20MAPK72.24659105
21ACVR1B2.17760094
22TXK2.17087834
23GRK72.12701931
24MOS1.88108765
25MAP3K101.87783055
26MAPK131.86501052
27PINK11.84335896
28NUAK11.81909590
29NTRK11.74292248
30ZAK1.71767831
31WNK11.67694941
32MAP2K71.66164409
33CDK71.64391198
34CSNK1A1L1.59792108
35MARK21.52701152
36PRKG21.47746907
37INSRR1.41336071
38STK391.40364008
39CAMK41.33258218
40WNK41.31266004
41PIK3CG1.23837006
42HIPK21.22557567
43OXSR11.22492804
44TEC1.21918255
45PAK41.18052491
46MAP3K71.16922800
47CASK1.11455245
48STK38L1.10605940
49FGFR31.09608008
50EPHA21.09108505
51TRIM281.03236915
52PRKCE1.02563371
53MARK11.02111106
54DYRK31.00916624
55AKT20.98698535
56ALK0.98313118
57MKNK20.97481251
58ADRBK10.95723250
59PLK20.94331269
60CHEK20.94200733
61MAP2K40.86990509
62DAPK20.85811497
63CSNK1G20.83323694
64MAPK120.82636345
65SIK20.82397505
66CSK0.82222498
67PLK10.78628149
68SGK20.77449125
69NTRK30.77065560
70TNIK0.76791835
71TGFBR10.72952838
72PAK30.72660493
73MAP2K60.68897710
74CHEK10.66595211
75ITK0.66016700
76CSNK1G10.65833786
77PTK2B0.64838132
78CSNK1G30.63257943
79IRAK10.60714596
80NEK20.58805203
81MARK30.56485757
82MUSK0.55021991
83NLK0.54484698
84CDC70.54482659
85PLK40.53849989
86FER0.53482092
87EPHA40.53216912
88PRKCG0.53150695
89MTOR0.52864231
90PIK3CA0.52685319
91PRKAA20.52386591
92CAMKK20.51799016
93PKN10.51048661
94TIE10.51041288
95CAMK10.50681805
96AKT30.50662076
97PRKCH0.49826831
98EIF2AK30.49451501
99SIK10.48709839
100MAPK40.48376073
101CAMK1G0.48241795
102SRPK10.47686398
103PRKCQ0.47532427
104SGK4940.46192362
105SGK2230.46192362
106FLT30.45710577
107PDK20.45178648
108EIF2AK20.44903697
109DYRK20.44865477
110PAK10.44261939
111AURKA0.43980856
112RIPK10.43856261
113CAMK2A0.42953069
114LYN0.42406944
115CHUK0.42035948
116CSNK1D0.41719682
117TRIB30.41014324
118ERBB30.40867063
119BRD40.40556908
120ERBB20.40418518
121CDK40.40376238
122STK110.39912673
123RPS6KB20.39392603
124DYRK1A0.39147197
125CDK30.38980634
126BMX0.38962759
127CDK20.38913723
128PRKCA0.38821016
129BCR0.38548039
130PRKCZ0.37899039
131OBSCN0.36753901
132EEF2K0.35754626
133PRKACA0.35374186
134CDK190.34603893
135LATS20.33752462
136IKBKB0.33099016
137CDK150.32721785
138PRKD20.32203580
139IGF1R0.31610048
140PDGFRA0.30430507
141MAPKAPK20.29947200
142CDK11A0.28789870
143PRKCI0.28332051
144ICK0.28219128
145PTK20.27835320
146CDK180.27551923
147KIT0.26358018
148SYK0.25838750
149MAP4K10.25136420
150PRKCD0.24100207
151BLK0.23253366
152CSNK1E0.21845628
153MAPK100.21165601
154MAP3K90.21093130
155CDK140.20724298
156TNK20.20600857
157DYRK1B0.20149795
158ATM0.19865103
159CDK10.19209123
160MST40.19203129
161MAPK140.18836719
162MAPK10.18667821
163HCK0.18594936
164PRKACG0.18457691
165MAPKAPK30.18146546
166INSR0.17821025
167PKN20.17659576
168GSK3B0.17193250
169AURKB0.16900983
170GSK3A0.14526709
171ABL10.13428049
172RPS6KA20.12341451
173LCK0.11198116
174PRKAA10.10274041
175BTK0.10211273
176IKBKE0.10133308

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.68483915
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.21839766
3Nicotine addiction_Homo sapiens_hsa050334.04412784
4Fructose and mannose metabolism_Homo sapiens_hsa000513.43408765
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42365363
6Phototransduction_Homo sapiens_hsa047442.85542513
7Arachidonic acid metabolism_Homo sapiens_hsa005902.81518127
8Morphine addiction_Homo sapiens_hsa050322.47486269
9Galactose metabolism_Homo sapiens_hsa000522.33225658
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.27679561
11Caffeine metabolism_Homo sapiens_hsa002322.20326531
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15947622
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.14375947
14Linoleic acid metabolism_Homo sapiens_hsa005912.11477588
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.03425878
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02882978
17Asthma_Homo sapiens_hsa053101.94477901
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94174549
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.93835850
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85768662
21GABAergic synapse_Homo sapiens_hsa047271.83288592
22mTOR signaling pathway_Homo sapiens_hsa041501.79836540
23Butanoate metabolism_Homo sapiens_hsa006501.74221887
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71106426
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.66540332
26Nitrogen metabolism_Homo sapiens_hsa009101.66059371
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57439785
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54819698
29Glycerolipid metabolism_Homo sapiens_hsa005611.53876152
30ABC transporters_Homo sapiens_hsa020101.53705379
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51060837
32Thyroid cancer_Homo sapiens_hsa052161.49758692
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44251037
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42417837
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30825671
36Salivary secretion_Homo sapiens_hsa049701.28898131
37Inositol phosphate metabolism_Homo sapiens_hsa005621.28434471
38mRNA surveillance pathway_Homo sapiens_hsa030151.28045552
39RNA transport_Homo sapiens_hsa030131.24100445
40Histidine metabolism_Homo sapiens_hsa003401.23380070
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22074984
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20614614
43Retinol metabolism_Homo sapiens_hsa008301.20438104
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18798221
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.17536084
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.12435430
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09204110
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07934588
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06674856
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05833739
51Primary immunodeficiency_Homo sapiens_hsa053401.04942099
52One carbon pool by folate_Homo sapiens_hsa006701.03864401
53Calcium signaling pathway_Homo sapiens_hsa040201.02872585
54Ovarian steroidogenesis_Homo sapiens_hsa049131.01829785
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.00984993
56Dorso-ventral axis formation_Homo sapiens_hsa043201.00289124
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.99340564
58Basal transcription factors_Homo sapiens_hsa030220.98809810
59Acute myeloid leukemia_Homo sapiens_hsa052210.98707147
60Propanoate metabolism_Homo sapiens_hsa006400.98287368
61MicroRNAs in cancer_Homo sapiens_hsa052060.97934317
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95903811
63Allograft rejection_Homo sapiens_hsa053300.93873012
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93464849
65Circadian entrainment_Homo sapiens_hsa047130.92415906
66Cell cycle_Homo sapiens_hsa041100.92010875
67Non-small cell lung cancer_Homo sapiens_hsa052230.91480337
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89622035
69Autoimmune thyroid disease_Homo sapiens_hsa053200.87697169
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86912945
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86211555
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85394892
73Fanconi anemia pathway_Homo sapiens_hsa034600.85000036
74Regulation of autophagy_Homo sapiens_hsa041400.84857561
75Glutamatergic synapse_Homo sapiens_hsa047240.83238181
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.82663639
77Circadian rhythm_Homo sapiens_hsa047100.79734552
78Pathways in cancer_Homo sapiens_hsa052000.79621021
79Graft-versus-host disease_Homo sapiens_hsa053320.79250528
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78862538
81Ether lipid metabolism_Homo sapiens_hsa005650.77955594
82B cell receptor signaling pathway_Homo sapiens_hsa046620.77630084
83African trypanosomiasis_Homo sapiens_hsa051430.76672067
84DNA replication_Homo sapiens_hsa030300.76244596
85Choline metabolism in cancer_Homo sapiens_hsa052310.76086592
86Chemical carcinogenesis_Homo sapiens_hsa052040.74666092
87Sulfur relay system_Homo sapiens_hsa041220.73086093
88Non-homologous end-joining_Homo sapiens_hsa034500.70909497
89Rap1 signaling pathway_Homo sapiens_hsa040150.68594565
90beta-Alanine metabolism_Homo sapiens_hsa004100.67792552
91Ribosome_Homo sapiens_hsa030100.67426574
92Insulin secretion_Homo sapiens_hsa049110.66947731
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66736582
94VEGF signaling pathway_Homo sapiens_hsa043700.66273628
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.65525695
96p53 signaling pathway_Homo sapiens_hsa041150.64650468
97Dopaminergic synapse_Homo sapiens_hsa047280.64345160
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63905989
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.63635960
100Homologous recombination_Homo sapiens_hsa034400.63621257
101Gastric acid secretion_Homo sapiens_hsa049710.62878715
102Olfactory transduction_Homo sapiens_hsa047400.62726066
103Other glycan degradation_Homo sapiens_hsa005110.62195485
104Taste transduction_Homo sapiens_hsa047420.62078688
105Type I diabetes mellitus_Homo sapiens_hsa049400.61334143
106Proteoglycans in cancer_Homo sapiens_hsa052050.60009646
107Renin secretion_Homo sapiens_hsa049240.58026667
108Cocaine addiction_Homo sapiens_hsa050300.57857115
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57258647
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.56790329
111Notch signaling pathway_Homo sapiens_hsa043300.56529908
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54349067
113Cholinergic synapse_Homo sapiens_hsa047250.54059914
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.53398917
115Folate biosynthesis_Homo sapiens_hsa007900.53010270
116Pancreatic cancer_Homo sapiens_hsa052120.52649072
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52228060
118Staphylococcus aureus infection_Homo sapiens_hsa051500.52010790
119Bladder cancer_Homo sapiens_hsa052190.51579349
120Basal cell carcinoma_Homo sapiens_hsa052170.51522823
121RNA degradation_Homo sapiens_hsa030180.51050594
122Herpes simplex infection_Homo sapiens_hsa051680.50991046
123Peroxisome_Homo sapiens_hsa041460.50718093
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50035147
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.49418997
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48230107
127Renin-angiotensin system_Homo sapiens_hsa046140.47649053
128AMPK signaling pathway_Homo sapiens_hsa041520.47394826
129Apoptosis_Homo sapiens_hsa042100.45959444
130Lysine degradation_Homo sapiens_hsa003100.45801356
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44986324
132Mismatch repair_Homo sapiens_hsa034300.44878049
133Sphingolipid metabolism_Homo sapiens_hsa006000.44768210
134Tryptophan metabolism_Homo sapiens_hsa003800.44539214
135Pentose phosphate pathway_Homo sapiens_hsa000300.43525557
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41748520
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41202940
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40336430
139Platelet activation_Homo sapiens_hsa046110.38204052
140GnRH signaling pathway_Homo sapiens_hsa049120.37150944
141Spliceosome_Homo sapiens_hsa030400.36618859
142Selenocompound metabolism_Homo sapiens_hsa004500.36578198
143Tight junction_Homo sapiens_hsa045300.35249096
144HTLV-I infection_Homo sapiens_hsa051660.35182257
145Viral carcinogenesis_Homo sapiens_hsa052030.35040853
146Oxytocin signaling pathway_Homo sapiens_hsa049210.34873560
147cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34394157
148Ras signaling pathway_Homo sapiens_hsa040140.34375643
149Starch and sucrose metabolism_Homo sapiens_hsa005000.33793190
150Base excision repair_Homo sapiens_hsa034100.33718986
151Hedgehog signaling pathway_Homo sapiens_hsa043400.33117753
152Long-term depression_Homo sapiens_hsa047300.33099179
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32644216
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32464961
155Thyroid hormone synthesis_Homo sapiens_hsa049180.32246459
156Purine metabolism_Homo sapiens_hsa002300.32118001
157Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31708424
158Hematopoietic cell lineage_Homo sapiens_hsa046400.31393602
159T cell receptor signaling pathway_Homo sapiens_hsa046600.31347262
160Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31217799
161Dilated cardiomyopathy_Homo sapiens_hsa054140.30443020
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29916236
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.29387387
164Hippo signaling pathway_Homo sapiens_hsa043900.28503735
165PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25210992
166Neurotrophin signaling pathway_Homo sapiens_hsa047220.24709543
167cAMP signaling pathway_Homo sapiens_hsa040240.23168824
168Serotonergic synapse_Homo sapiens_hsa047260.22653590

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