TACC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.01754878
2presynaptic membrane organization (GO:0097090)5.31568591
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.79227073
4postsynaptic membrane organization (GO:0001941)4.72969917
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46770594
6short-term memory (GO:0007614)4.28316889
7neuronal action potential propagation (GO:0019227)4.26585802
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.97247321
9vocalization behavior (GO:0071625)3.83616296
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.73927714
11ionotropic glutamate receptor signaling pathway (GO:0035235)3.73527805
12neurotransmitter-gated ion channel clustering (GO:0072578)3.70663832
13protein localization to synapse (GO:0035418)3.69131742
14cAMP catabolic process (GO:0006198)3.61575525
15regulation of glutamate receptor signaling pathway (GO:1900449)3.57517271
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55074646
17cyclic nucleotide catabolic process (GO:0009214)3.44386458
18regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39344056
19mechanosensory behavior (GO:0007638)3.37681061
20neuron cell-cell adhesion (GO:0007158)3.36925667
21positive regulation of gamma-delta T cell activation (GO:0046645)3.31911459
22regulation of protein kinase A signaling (GO:0010738)3.24005972
23positive regulation of fibroblast migration (GO:0010763)3.23449482
24positive regulation of membrane potential (GO:0045838)3.18135404
25cellular extravasation (GO:0045123)3.14896253
26glutamate receptor signaling pathway (GO:0007215)3.12680467
27angiogenesis involved in wound healing (GO:0060055)3.11584612
28regulation of postsynaptic membrane potential (GO:0060078)3.11004019
29synaptic transmission, glutamatergic (GO:0035249)3.08367545
30negative regulation of execution phase of apoptosis (GO:1900118)3.07555500
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06063124
32protein localization to endosome (GO:0036010)3.04745782
33neuron-neuron synaptic transmission (GO:0007270)3.04288426
34synaptic vesicle exocytosis (GO:0016079)3.03727601
35B cell receptor signaling pathway (GO:0050853)3.00319846
36long-term memory (GO:0007616)2.99925788
37membrane assembly (GO:0071709)2.98563096
38regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.97278675
39positive regulation of neurotransmitter secretion (GO:0001956)2.96176535
40negative regulation of erythrocyte differentiation (GO:0045647)2.92102075
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91905166
42long-term synaptic potentiation (GO:0060291)2.89119062
43mast cell degranulation (GO:0043303)2.88250466
44mast cell activation involved in immune response (GO:0002279)2.88250466
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87560495
46positive regulation of macrophage cytokine production (GO:0060907)2.85578543
47locomotory exploration behavior (GO:0035641)2.84922216
48regulation of synaptic vesicle exocytosis (GO:2000300)2.84286902
49positive regulation of Rap GTPase activity (GO:0032854)2.83803773
50L-amino acid import (GO:0043092)2.82818450
51mast cell activation (GO:0045576)2.82334931
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.80581156
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79735209
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77754112
55regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76250732
56regulation of dendritic spine development (GO:0060998)2.75477633
57negative regulation of phagocytosis (GO:0050765)2.74371719
58antigen processing and presentation of endogenous antigen (GO:0019883)2.73958391
59regulation of B cell receptor signaling pathway (GO:0050855)2.73273061
60cellular response to ethanol (GO:0071361)2.73270230
61regulation of macrophage cytokine production (GO:0010935)2.69891349
62regulation of inositol phosphate biosynthetic process (GO:0010919)2.69263986
63regulation of synaptic transmission, glutamatergic (GO:0051966)2.68239440
64regulation of glutamate secretion (GO:0014048)2.67827719
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67808970
66negative regulation of cell killing (GO:0031342)2.67808970
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67261634
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.67261634
69modulation by symbiont of host immune response (GO:0052553)2.67261634
70positive regulation by symbiont of host defense response (GO:0052509)2.67261634
71modulation by symbiont of host defense response (GO:0052031)2.67261634
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67261634
73membrane depolarization (GO:0051899)2.65647934
74macrophage activation involved in immune response (GO:0002281)2.64172838
75establishment of endothelial barrier (GO:0061028)2.63984735
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63305860
77auditory behavior (GO:0031223)2.61600742
78glutamate secretion (GO:0014047)2.61518052
79regulation of gamma-delta T cell activation (GO:0046643)2.61506618
80regulation of synaptic plasticity (GO:0048167)2.61306203
81negative regulation of neurotransmitter secretion (GO:0046929)2.60873952
82startle response (GO:0001964)2.59615997
83negative regulation of neurotransmitter transport (GO:0051589)2.59092359
84positive regulation of neurotransmitter transport (GO:0051590)2.58959287
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58730768
86negative regulation of dendrite morphogenesis (GO:0050774)2.56886412
87regulation of voltage-gated calcium channel activity (GO:1901385)2.56846340
88membrane raft organization (GO:0031579)2.56188096
89negative regulation of amino acid transport (GO:0051956)2.53881763
90nerve growth factor signaling pathway (GO:0038180)2.53390801
91negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.52911638
92neutrophil mediated immunity (GO:0002446)2.51981435
93germinal center formation (GO:0002467)2.51834929
94detection of molecule of bacterial origin (GO:0032490)2.51416902
95cellular response to epinephrine stimulus (GO:0071872)2.51150489
96stress fiber assembly (GO:0043149)2.50243072
97cAMP metabolic process (GO:0046058)2.49402027
98response to muramyl dipeptide (GO:0032495)2.48801716
99synaptic vesicle maturation (GO:0016188)2.48349461
100regulation of synaptic vesicle transport (GO:1902803)2.48168031
101positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.47161190
102regulation of neuronal synaptic plasticity (GO:0048168)2.46229699
103axon ensheathment in central nervous system (GO:0032291)2.45939263
104central nervous system myelination (GO:0022010)2.45939263
105visual learning (GO:0008542)2.45928828
106regulation of macrophage chemotaxis (GO:0010758)2.45524582
107regulation of dendritic spine morphogenesis (GO:0061001)2.45344661
108positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43493658
109cortical actin cytoskeleton organization (GO:0030866)2.43353589
110regulation of pigment cell differentiation (GO:0050932)2.43237476
111response to histamine (GO:0034776)2.42832419
112serotonin metabolic process (GO:0042428)2.42566865
113regulation of gamma-delta T cell differentiation (GO:0045586)2.42231538
114adult walking behavior (GO:0007628)2.40286781
115regulation of ARF protein signal transduction (GO:0032012)2.39865352
116myeloid leukocyte mediated immunity (GO:0002444)2.38046609
117regulation of long-term neuronal synaptic plasticity (GO:0048169)2.37919728
118positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.36069840
119regulation of interferon-beta biosynthetic process (GO:0045357)2.35271509
120adenosine receptor signaling pathway (GO:0001973)2.35236658
121glycine transport (GO:0015816)2.34397850
122cGMP metabolic process (GO:0046068)2.33528354
123monocyte differentiation (GO:0030224)2.32286636
124associative learning (GO:0008306)2.32168466
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.31719570
126positive regulation of receptor recycling (GO:0001921)2.31491596
127positive regulation of synaptic transmission (GO:0050806)2.30738530
128surfactant homeostasis (GO:0043129)2.30442470
129vesicle docking involved in exocytosis (GO:0006904)2.30028019
130negative regulation of leukocyte chemotaxis (GO:0002689)2.29928481
131phosphorelay signal transduction system (GO:0000160)2.29743143
132regulation of respiratory system process (GO:0044065)2.29035365
133cerebellar Purkinje cell differentiation (GO:0021702)2.28746095
134response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.27756036
135response to host (GO:0075136)2.27756036
136response to host defenses (GO:0052200)2.27756036
137positive regulation of dendritic spine development (GO:0060999)2.27716504
138positive thymic T cell selection (GO:0045059)2.27043836
139learning (GO:0007612)2.27041294
140hypotonic response (GO:0006971)2.26950001
141Rap protein signal transduction (GO:0032486)2.26114578
142regulation of Rap GTPase activity (GO:0032317)2.25870738
143growth hormone receptor signaling pathway (GO:0060396)2.25226798
144regulation of synaptic transmission, GABAergic (GO:0032228)2.25192178
145negative regulation of growth of symbiont in host (GO:0044130)2.24657615
146negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.24657615
147modulation of growth of symbiont involved in interaction with host (GO:0044144)2.24657615
148regulation of growth of symbiont in host (GO:0044126)2.24657615
149detection of other organism (GO:0098543)2.24441732
150response to epinephrine (GO:0071871)2.24356789
151cytoskeletal anchoring at plasma membrane (GO:0007016)2.23309811
152macrophage activation (GO:0042116)2.23045379
153platelet-derived growth factor receptor signaling pathway (GO:0048008)2.22745274
154positive regulation of cellular amide metabolic process (GO:0034250)2.21473770
155B cell homeostasis (GO:0001782)2.21248391
156response to host immune response (GO:0052572)2.18098050
157response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.18098050
158response to interleukin-15 (GO:0070672)2.16776912
159endothelium development (GO:0003158)2.16707332
160interferon-gamma-mediated signaling pathway (GO:0060333)2.14926395
161detection of external biotic stimulus (GO:0098581)2.14400102
162cellular response to thyroid hormone stimulus (GO:0097067)2.13681793
163negative regulation of anoikis (GO:2000811)2.13287683
164mannose metabolic process (GO:0006013)2.13268815
165T cell migration (GO:0072678)2.10246107
166regulation of protein polyubiquitination (GO:1902914)2.09608453
167blood vessel maturation (GO:0001955)2.09038260
168interleukin-6-mediated signaling pathway (GO:0070102)2.08366325
169regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.07470638
170negative regulation of interleukin-12 production (GO:0032695)2.07078960
171JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.06039578
172negative thymic T cell selection (GO:0045060)2.05945461
173mRNA transcription (GO:0009299)2.05665892
174regulation of dendritic cell antigen processing and presentation (GO:0002604)2.05629126
175cortical cytoskeleton organization (GO:0030865)2.05601120
176negative regulation of fatty acid transport (GO:2000192)2.05297624
177microglial cell activation (GO:0001774)2.04749187
178regulation of fibroblast migration (GO:0010762)2.02609799
179response to peptidoglycan (GO:0032494)2.02091864
180response to type I interferon (GO:0034340)2.01869219
181sprouting angiogenesis (GO:0002040)2.01351146
182cell volume homeostasis (GO:0006884)2.01237200
183regulation of extracellular matrix disassembly (GO:0010715)2.00611762
184focal adhesion assembly (GO:0048041)2.00452241
185cell-substrate adherens junction assembly (GO:0007045)2.00452241
186phospholipid translocation (GO:0045332)1.99071835
187lipid translocation (GO:0034204)1.99071835
188regulation of T-helper 2 cell differentiation (GO:0045628)1.98719450
189cellular response to growth hormone stimulus (GO:0071378)1.98603282
190CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)1.98522451
191detection of bacterium (GO:0016045)1.98226345
192type I interferon signaling pathway (GO:0060337)1.98205726
193cellular response to type I interferon (GO:0071357)1.98205726
194positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.97726275
195negative T cell selection (GO:0043383)1.97002583
196insulin-like growth factor receptor signaling pathway (GO:0048009)1.96681921
197phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.95395070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13222041
2GBX2_23144817_ChIP-Seq_PC3_Human3.87290488
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.27286192
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93121982
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53692698
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50614080
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47809971
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30568031
9AR_21572438_ChIP-Seq_LNCaP_Human2.22593353
10TAF15_26573619_Chip-Seq_HEK293_Human2.20966172
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20062696
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18960366
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.13956060
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13769634
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12154520
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10776680
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10776680
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10204384
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08121154
20GATA1_22025678_ChIP-Seq_K562_Human2.01022870
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.98077996
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96914042
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92769207
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92478247
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.92156569
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89858184
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86630677
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.83849786
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81887742
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78573093
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77136935
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74309665
33DROSHA_22980978_ChIP-Seq_HELA_Human1.74297041
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71402367
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67834840
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63779182
37SMAD4_21799915_ChIP-Seq_A2780_Human1.61343118
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58277984
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.57695754
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56879112
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.56004923
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55277373
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53439540
44* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52538096
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51728697
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50525857
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49639294
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49048293
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.48399089
50* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46828360
51ER_23166858_ChIP-Seq_MCF-7_Human1.46374657
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.45901607
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45842998
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45547829
55* P300_19829295_ChIP-Seq_ESCs_Human1.44937520
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.43101463
57* SPI1_23127762_ChIP-Seq_K562_Human1.42110840
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40528933
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39915067
60* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38164472
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37037573
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.36455137
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.35970006
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33637381
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.32658787
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32585523
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32098625
68GATA1_19941826_ChIP-Seq_K562_Human1.32085994
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31969800
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31838777
71REST_21632747_ChIP-Seq_MESCs_Mouse1.31798860
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31368772
73P53_22387025_ChIP-Seq_ESCs_Mouse1.29611219
74VDR_24763502_ChIP-Seq_THP-1_Human1.29202490
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28912930
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.28674596
77RUNX_20019798_ChIP-Seq_JUKART_Human1.28147813
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27443618
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27414350
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.26642747
81* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26307086
82* TCF7_22412390_ChIP-Seq_EML_Mouse1.25686707
83* TCF4_23295773_ChIP-Seq_U87_Human1.25241072
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25191500
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.24033770
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.24033770
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.23857534
88SCL_19346495_ChIP-Seq_HPC-7_Human1.23466969
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23271690
90STAT3_23295773_ChIP-Seq_U87_Human1.23048360
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22935778
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22346826
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.22234739
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22119119
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.21167503
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.21065510
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.20386026
98* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20117553
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.19736542
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19729381
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.19630253
102P300_18555785_Chip-Seq_ESCs_Mouse1.18950383
103TRIM28_21343339_ChIP-Seq_HEK293_Human1.18871893
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.18529824
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18489377
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18387069
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17349061
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.17083678
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16212259
110MYB_26560356_Chip-Seq_TH2_Human1.15923739
111* IRF8_27001747_Chip-Seq_BMDM_Mouse1.15830297
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.15787794
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15318435
114GATA2_19941826_ChIP-Seq_K562_Human1.14472657
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13796785
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13225214
117FOXA2_19822575_ChIP-Seq_HepG2_Human1.12675449
118RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12663029
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.12548734
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11859576
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.11303827
122STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10896549
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.10684061
124CJUN_26792858_Chip-Seq_BT549_Human1.10570961
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.10269313
126* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09827157
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09267654
128PU1_27457419_Chip-Seq_LIVER_Mouse1.07541724
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07431136
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07225170
131NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07225170
132* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06155657
133* AR_25329375_ChIP-Seq_VCAP_Human1.05725245
134* KDM2B_26808549_Chip-Seq_REH_Human1.05222090
135BRD4_25478319_ChIP-Seq_HGPS_Human1.05114558
136AHR_22903824_ChIP-Seq_MCF-7_Human1.05103172
137NMYC_18555785_Chip-Seq_ESCs_Mouse1.04199115
138PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03611331
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03419869
140TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01548469
141ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00519245
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99667371
143TP53_16413492_ChIP-PET_HCT116_Human0.99651323
144RUNX2_22187159_ChIP-Seq_PCA_Human0.99214397
145CLOCK_20551151_ChIP-Seq_293T_Human0.99172543
146PU_27001747_Chip-Seq_BMDM_Mouse0.99093640
147* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98994171
148MYB_26560356_Chip-Seq_TH1_Human0.98779945
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98678573
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98555665
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98555665
152* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98453879
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98112321
154VDR_24787735_ChIP-Seq_THP-1_Human0.98063060
155RNF2_27304074_Chip-Seq_NSC_Mouse0.97938924
156* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97522535
157KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96819859
158ESR1_20079471_ChIP-ChIP_T-47D_Human0.96777400
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96136485
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95361981
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.95121786
162* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94317654
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94014543
164* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93161206
165KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91492189
166KDM2B_26808549_Chip-Seq_DND41_Human0.91053241
167RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90909146
168NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90840954
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89920891
170ELK3_25401928_ChIP-Seq_HUVEC_Human0.88735068
171THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88122894
172MYC_22102868_ChIP-Seq_BL_Human0.86567506
173GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86465593
174MAF_26560356_Chip-Seq_TH1_Human0.85755514
175GATA3_27048872_Chip-Seq_THYMUS_Human0.84106405
176VDR_21846776_ChIP-Seq_THP-1_Human0.83564991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.34313816
2MP0005409_darkened_coat_color3.91197421
3MP0004859_abnormal_synaptic_plasticity3.47484989
4MP0001188_hyperpigmentation3.29224012
5MP0003300_gastrointestinal_ulcer3.18786614
6MP0003136_yellow_coat_color3.03922401
7MP0008438_abnormal_cutaneous_collagen2.65250653
8MP0003635_abnormal_synaptic_transmissio2.53675537
9MP0009745_abnormal_behavioral_response2.52513396
10MP0005171_absent_coat_pigmentation2.45905384
11MP0003724_increased_susceptibility_to2.44263783
12MP0003303_peritoneal_inflammation2.43994911
13MP0000015_abnormal_ear_pigmentation2.40603867
14MP0001968_abnormal_touch/_nociception2.38231780
15MP0002064_seizures2.34937419
16MP0009046_muscle_twitch2.32673711
17MP0000685_abnormal_immune_system2.29566941
18MP0003091_abnormal_cell_migration2.26512366
19MP0001958_emphysema2.22634419
20MP0002272_abnormal_nervous_system2.09136474
21MP0001486_abnormal_startle_reflex2.04782026
22MP0010368_abnormal_lymphatic_system2.02974145
23MP0003566_abnormal_cell_adhesion2.02927821
24MP0002877_abnormal_melanocyte_morpholog2.00383734
25MP0005174_abnormal_tail_pigmentation1.96423233
26MP0004270_analgesia1.90253564
27MP0002063_abnormal_learning/memory/cond1.89856041
28MP0003705_abnormal_hypodermis_morpholog1.88632982
29MP0003950_abnormal_plasma_membrane1.88445201
30MP0004381_abnormal_hair_follicle1.87963634
31MP0002572_abnormal_emotion/affect_behav1.86067203
32MP0010352_gastrointestinal_tract_polyps1.81521340
33MP0003436_decreased_susceptibility_to1.80478520
34MP0000920_abnormal_myelination1.75284902
35MP0002067_abnormal_sensory_capabilities1.73624557
36MP0004742_abnormal_vestibular_system1.73137628
37MP0008569_lethality_at_weaning1.71897410
38MP0003279_aneurysm1.70764628
39MP0002736_abnormal_nociception_after1.69848050
40MP0003763_abnormal_thymus_physiology1.66784785
41MP0002876_abnormal_thyroid_physiology1.59758162
42MP0002006_tumorigenesis1.58817241
43MP0001501_abnormal_sleep_pattern1.57920070
44MP0005275_abnormal_skin_tensile1.57561685
45MP0005646_abnormal_pituitary_gland1.48410293
46MP0002735_abnormal_chemical_nociception1.47267239
47MP0003191_abnormal_cellular_cholesterol1.45710740
48MP0002138_abnormal_hepatobiliary_system1.45579448
49MP0000569_abnormal_digit_pigmentation1.43461068
50MP0004147_increased_porphyrin_level1.42528867
51MP0003183_abnormal_peptide_metabolism1.40042617
52MP0008260_abnormal_autophagy1.37425900
53MP0001879_abnormal_lymphatic_vessel1.35671567
54MP0005423_abnormal_somatic_nervous1.35513058
55MP0002734_abnormal_mechanical_nocicepti1.34542871
56MP0009780_abnormal_chondrocyte_physiolo1.33524011
57MP0003690_abnormal_glial_cell1.33180651
58MP0003879_abnormal_hair_cell1.32270305
59MP0004947_skin_inflammation1.31836715
60MP0004142_abnormal_muscle_tone1.31668866
61MP0000767_abnormal_smooth_muscle1.31630775
62MP0003633_abnormal_nervous_system1.30546984
63MP0002822_catalepsy1.29985056
64MP0001970_abnormal_pain_threshold1.28742610
65MP0002933_joint_inflammation1.25755900
66MP0002419_abnormal_innate_immunity1.25668137
67MP0000013_abnormal_adipose_tissue1.25294452
68MP0004130_abnormal_muscle_cell1.24119066
69MP0003045_fibrosis1.23369039
70MP0005671_abnormal_response_to1.22318085
71MP0008874_decreased_physiological_sensi1.21561992
72MP0005023_abnormal_wound_healing1.19020066
73MP0001986_abnormal_taste_sensitivity1.18364911
74MP0005670_abnormal_white_adipose1.14715460
75MP0004883_abnormal_blood_vessel1.14455522
76MP0002009_preneoplasia1.13881761
77MP0000249_abnormal_blood_vessel1.13270653
78MP0004084_abnormal_cardiac_muscle1.13177329
79MP0001835_abnormal_antigen_presentation1.10490443
80MP0005058_abnormal_lysosome_morphology1.08955648
81MP0006054_spinal_hemorrhage1.06783565
82MP0004036_abnormal_muscle_relaxation1.06305786
83MP0003787_abnormal_imprinting1.06031694
84MP0002168_other_aberrant_phenotype1.06008302
85MP0009785_altered_susceptibility_to1.05350099
86MP0002095_abnormal_skin_pigmentation1.04856414
87MP0005165_increased_susceptibility_to1.04720534
88MP0001440_abnormal_grooming_behavior1.04716525
89MP0002405_respiratory_system_inflammati1.04245271
90MP0003631_nervous_system_phenotype1.02815551
91MP0005000_abnormal_immune_tolerance1.01833470
92MP0002557_abnormal_social/conspecific_i1.01507986
93MP0006082_CNS_inflammation1.01374387
94MP0002398_abnormal_bone_marrow1.00356684
95MP0000751_myopathy1.00129727
96MP0002733_abnormal_thermal_nociception1.00089234
97MP0005166_decreased_susceptibility_to0.99796884
98MP0009115_abnormal_fat_cell0.98738205
99MP0010155_abnormal_intestine_physiology0.98030532
100MP0001905_abnormal_dopamine_level0.97673514
101MP0000716_abnormal_immune_system0.96924140
102MP0005310_abnormal_salivary_gland0.96657498
103MP0000003_abnormal_adipose_tissue0.96576195
104MP0003075_altered_response_to0.95797949
105MP0001845_abnormal_inflammatory_respons0.95696866
106MP0001502_abnormal_circadian_rhythm0.95652852
107MP0000465_gastrointestinal_hemorrhage0.95595341
108MP0005375_adipose_tissue_phenotype0.93653479
109MP0006138_congestive_heart_failure0.93355092
110MP0004272_abnormal_basement_membrane0.92880023
111MP0003868_abnormal_feces_composition0.92792753
112MP0002148_abnormal_hypersensitivity_rea0.91162217
113MP0004808_abnormal_hematopoietic_stem0.90651178
114MP0005075_abnormal_melanosome_morpholog0.89632501
115MP0006292_abnormal_olfactory_placode0.89276104
116MP0002396_abnormal_hematopoietic_system0.88615633
117MP0005666_abnormal_adipose_tissue0.87438996
118MP0004811_abnormal_neuron_physiology0.87214357
119MP0002420_abnormal_adaptive_immunity0.86856933
120MP0005076_abnormal_cell_differentiation0.86685010
121MP0008004_abnormal_stomach_pH0.86652606
122MP0001963_abnormal_hearing_physiology0.86447115
123MP0005164_abnormal_response_to0.85443732
124MP0008877_abnormal_DNA_methylation0.84764460
125MP0001819_abnormal_immune_cell0.84569168
126MP0005464_abnormal_platelet_physiology0.84406405
127MP0001853_heart_inflammation0.84353892
128MP0002971_abnormal_brown_adipose0.84175455
129MP0001177_atelectasis0.81828864
130MP0009840_abnormal_foam_cell0.80519001
131MP0003828_pulmonary_edema0.80420029
132MP0005167_abnormal_blood-brain_barrier0.80182860
133MP0004510_myositis0.79319763
134MP0000604_amyloidosis0.79261871
135MP0004924_abnormal_behavior0.78792348
136MP0005386_behavior/neurological_phenoty0.78792348
137MP0004484_altered_response_of0.78724185
138MP0002066_abnormal_motor_capabilities/c0.78069855
139MP0005623_abnormal_meninges_morphology0.77970989
140MP0001790_abnormal_immune_system0.77535790
141MP0005387_immune_system_phenotype0.77535790
142MP0002166_altered_tumor_susceptibility0.76863003
143MP0002452_abnormal_antigen_presenting0.76831006
144MP0002723_abnormal_immune_serum0.76767682
145MP0005595_abnormal_vascular_smooth0.76713902
146MP0001851_eye_inflammation0.76104972
147MP0008995_early_reproductive_senescence0.73769619
148MP0003172_abnormal_lysosome_physiology0.72615599
149MP0005535_abnormal_body_temperature0.71608786
150MP0002229_neurodegeneration0.71464340
151MP0000343_altered_response_to0.71008806
152MP0005025_abnormal_response_to0.70137731
153MP0001800_abnormal_humoral_immune0.69102644
154MP0002882_abnormal_neuron_morphology0.67754921
155MP0001533_abnormal_skeleton_physiology0.66171269
156MP0005388_respiratory_system_phenotype0.66114023
157MP0002133_abnormal_respiratory_system0.66114023
158MP0000778_abnormal_nervous_system0.65843649
159MP0002998_abnormal_bone_remodeling0.64156128

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.44873485
2Epileptic encephalopathy (HP:0200134)3.90353450
3Aortic aneurysm (HP:0004942)3.84591434
4Febrile seizures (HP:0002373)3.78525775
5Atonic seizures (HP:0010819)3.64129094
6Broad-based gait (HP:0002136)3.49121782
7Focal seizures (HP:0007359)3.43377972
8Gaze-evoked nystagmus (HP:0000640)3.39276110
9Obstructive sleep apnea (HP:0002870)3.18012968
10Papilledema (HP:0001085)3.14658959
11Abnormal hair whorl (HP:0010721)2.99220266
12Thyroid-stimulating hormone excess (HP:0002925)2.94826948
13Protrusio acetabuli (HP:0003179)2.92433991
14Aortic dissection (HP:0002647)2.88125789
15Hyperventilation (HP:0002883)2.84886384
16Myokymia (HP:0002411)2.84542064
17Osteolytic defects of the hand bones (HP:0009699)2.78657075
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.78657075
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78646184
20Agammaglobulinemia (HP:0004432)2.77445902
21Progressive cerebellar ataxia (HP:0002073)2.73724132
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.73458102
23Absent/shortened dynein arms (HP:0200106)2.73458102
24Sensory axonal neuropathy (HP:0003390)2.73188794
25Gastrointestinal stroma tumor (HP:0100723)2.67334309
26Cerebral aneurysm (HP:0004944)2.64705618
27Vascular tortuosity (HP:0004948)2.64478970
28Recurrent abscess formation (HP:0002722)2.63669030
29Arterial tortuosity (HP:0005116)2.60200975
30Meningitis (HP:0001287)2.60055234
31Hematochezia (HP:0002573)2.58857194
32Interstitial pulmonary disease (HP:0006530)2.57605790
33Chronic obstructive pulmonary disease (HP:0006510)2.56230662
34Obstructive lung disease (HP:0006536)2.56230662
35Blue irides (HP:0000635)2.51795353
36Ocular albinism (HP:0001107)2.50531861
37Absent speech (HP:0001344)2.46507264
38Scanning speech (HP:0002168)2.44462488
39Persistence of primary teeth (HP:0006335)2.38276968
40Emphysema (HP:0002097)2.37462502
41Iris hypopigmentation (HP:0007730)2.37152407
42Generalized tonic-clonic seizures (HP:0002069)2.35712230
43Glucose intolerance (HP:0000833)2.35132617
44Dilatation of the ascending aorta (HP:0005111)2.34731940
45Aneurysm (HP:0002617)2.33977252
46Submucous cleft hard palate (HP:0000176)2.31841741
47Protruding tongue (HP:0010808)2.28235926
48Nonprogressive disorder (HP:0003680)2.28070015
49Dialeptic seizures (HP:0011146)2.26736548
50White forelock (HP:0002211)2.26408380
51Stomatitis (HP:0010280)2.26265874
52Abnormal sex determination (HP:0012244)2.25319836
53Sex reversal (HP:0012245)2.25319836
54Truncal ataxia (HP:0002078)2.23489213
55Absent frontal sinuses (HP:0002688)2.22627785
56Dysmetric saccades (HP:0000641)2.21194203
57Spontaneous hematomas (HP:0007420)2.19079388
58Abnormality of macrophages (HP:0004311)2.18344261
59Dysmetria (HP:0001310)2.18156579
60J-shaped sella turcica (HP:0002680)2.16882787
61Polycythemia (HP:0001901)2.14905397
62Prolonged bleeding time (HP:0003010)2.13732366
63Overgrowth (HP:0001548)2.13499213
64Action tremor (HP:0002345)2.12452359
65Colitis (HP:0002583)2.12288220
66Osteomyelitis (HP:0002754)2.12027414
67Abnormal ciliary motility (HP:0012262)2.11837541
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.11186145
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11186145
70Abnormal respiratory motile cilium physiology (HP:0012261)2.10833573
71Vasculitis (HP:0002633)2.10671231
72Bradycardia (HP:0001662)2.10469162
73Mucopolysacchariduria (HP:0008155)2.10357874
74Urinary glycosaminoglycan excretion (HP:0003541)2.10357874
75Recurrent gram-negative bacterial infections (HP:0005420)2.09797356
76Increased variability in muscle fiber diameter (HP:0003557)2.09610263
77Dysostosis multiplex (HP:0000943)2.09145458
78Abnormality of the axillary hair (HP:0100134)2.08677380
79Abnormality of secondary sexual hair (HP:0009888)2.08677380
80Urinary bladder sphincter dysfunction (HP:0002839)2.07960374
81Cellulitis (HP:0100658)2.06514168
82Abnormality of binocular vision (HP:0011514)2.05578117
83Diplopia (HP:0000651)2.05578117
84Sleep apnea (HP:0010535)2.05008436
85Striae distensae (HP:0001065)2.04715184
86Patchy hypopigmentation of hair (HP:0011365)2.04649727
87Wormian bones (HP:0002645)2.04618423
88Hypoplasia of the iris (HP:0007676)2.02715501
89Generalized hypopigmentation of hair (HP:0011358)2.02243032
90Generalized hypotonia (HP:0001290)2.01231491
91Recurrent bacterial skin infections (HP:0005406)2.00823052
92Abnormality of polysaccharide metabolism (HP:0011012)2.00731113
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00731113
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00731113
95Slow saccadic eye movements (HP:0000514)2.00639607
96Pulmonary infiltrates (HP:0002113)2.00193340
97Myocardial infarction (HP:0001658)2.00175874
98Hemiplegia (HP:0002301)1.98850957
99Subacute progressive viral hepatitis (HP:0006572)1.97892655
100Onion bulb formation (HP:0003383)1.97042041
101Increased connective tissue (HP:0009025)1.96821827
102Gingivitis (HP:0000230)1.96197166
103Hyporeflexia of lower limbs (HP:0002600)1.94585432
104Absence seizures (HP:0002121)1.94543957
105Lower limb amyotrophy (HP:0007210)1.93487778
106Restrictive lung disease (HP:0002091)1.92483087
107Recurrent bronchitis (HP:0002837)1.92348299
108Spondylolisthesis (HP:0003302)1.92162689
109Impaired smooth pursuit (HP:0007772)1.91769097
110Recurrent cutaneous fungal infections (HP:0011370)1.91474004
111Chronic mucocutaneous candidiasis (HP:0002728)1.91474004
112Conjunctival telangiectasia (HP:0000524)1.91426012
113Joint hemorrhage (HP:0005261)1.91192627
114Increased CSF protein (HP:0002922)1.89834778
115Clumsiness (HP:0002312)1.89375595
116Eosinophilia (HP:0001880)1.89371689
117Optic nerve hypoplasia (HP:0000609)1.88935320
118Menorrhagia (HP:0000132)1.88864014
119Abnormality of skeletal muscle fiber size (HP:0012084)1.88293924
120Recurrent viral infections (HP:0004429)1.87806893
121Esophageal varix (HP:0002040)1.86889996
122Dysdiadochokinesis (HP:0002075)1.86603306
123Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85604039
124Mediastinal lymphadenopathy (HP:0100721)1.85477397
125Gingival bleeding (HP:0000225)1.83735752
126Recurrent fungal infections (HP:0002841)1.83594859
127Abnormality of glycolipid metabolism (HP:0010969)1.83064867
128Abnormality of liposaccharide metabolism (HP:0010968)1.83064867
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.83064867
130Decreased circulating renin level (HP:0003351)1.82680139
131Eczematoid dermatitis (HP:0000976)1.81996925
132Abnormal glucose tolerance (HP:0001952)1.80907006
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.80326484
134Panhypogammaglobulinemia (HP:0003139)1.80244184
135Distal lower limb amyotrophy (HP:0008944)1.79755144
136Mitral valve prolapse (HP:0001634)1.79747795
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78269617
138Abnormal respiratory motile cilium morphology (HP:0005938)1.77240820
139Abnormal respiratory epithelium morphology (HP:0012253)1.77240820
140Genetic anticipation (HP:0003743)1.77143162
141Abnormality of the fingertips (HP:0001211)1.76971642
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76614387
143Mitral stenosis (HP:0001718)1.76469238
144IgA deficiency (HP:0002720)1.76360868
145Abnormal eating behavior (HP:0100738)1.75528991
146Premature rupture of membranes (HP:0001788)1.75348918
147Systemic lupus erythematosus (HP:0002725)1.75214707
148Mucosal telangiectasiae (HP:0100579)1.74645475
149Peripheral hypomyelination (HP:0007182)1.74479289
150Abnormality of saccadic eye movements (HP:0000570)1.74411058
151Chronic diarrhea (HP:0002028)1.72198008
152Poor eye contact (HP:0000817)1.71594388
153Hemorrhage of the eye (HP:0011885)1.70993779
154Thrombocytosis (HP:0001894)1.70979608
155Stereotypic behavior (HP:0000733)1.70940875
156Viral hepatitis (HP:0006562)1.70815721
157Rhinitis (HP:0012384)1.69892049
158Chest pain (HP:0100749)1.69318694
159Chronic otitis media (HP:0000389)1.68985767
160Orchitis (HP:0100796)1.68776853
161Fair hair (HP:0002286)1.68760584
162Recurrent skin infections (HP:0001581)1.68480781
163Cervical subluxation (HP:0003308)1.68414114
164Epistaxis (HP:0000421)1.68334093
165Hemoptysis (HP:0002105)1.67290843
166Asymmetric septal hypertrophy (HP:0001670)1.67236942
167Myositis (HP:0100614)1.65742937
168Amyloidosis (HP:0011034)1.65528545
169Inflammation of the large intestine (HP:0002037)1.65497705
170Abnormality of complement system (HP:0005339)1.65317617
171Abnormality of the right ventricle (HP:0001707)1.65280868
172Abnormal platelet volume (HP:0011876)1.64959340
173Abnormality of the frontal sinuses (HP:0002687)1.64671072
174Acrocyanosis (HP:0001063)1.64516925
175Thoracolumbar scoliosis (HP:0002944)1.64423684
176Depression (HP:0000716)1.64083647
177Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63226289
178Increased neuronal autofluorescent lipopigment (HP:0002074)1.63091910
179T lymphocytopenia (HP:0005403)1.62580856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.83416392
2MKNK22.95743611
3FES2.76712398
4EPHA42.51697371
5PRPF4B2.46520758
6NTRK32.14676918
7CLK12.11909863
8TNIK2.06672840
9NEK92.03232456
10FGFR31.95977769
11BLK1.82029467
12CDK191.80985324
13MAP2K71.79601161
14TYK21.79348550
15FGFR41.69431706
16DAPK21.68554202
17TLK11.61243399
18CDK121.60378519
19IRAK41.58912012
20MAP3K121.53391962
21ERN11.47766420
22MAP2K31.45651676
23TTN1.43081536
24SGK21.42353405
25MKNK11.41086837
26EEF2K1.40912412
27CDC42BPA1.38778453
28CCNB11.38449540
29OXSR11.35038343
30RIPK41.30646236
31RIPK11.28281463
32PDGFRA1.26712275
33ZAP701.24761393
34NLK1.24147399
35TXK1.24011704
36SGK4941.23652611
37SGK2231.23652611
38CAMKK21.23209225
39TRIB31.22460730
40AKT31.17822007
41MUSK1.10382781
42PDGFRB1.09894768
43DAPK11.09855401
44DDR21.05954884
45MAPKAPK31.04812527
46TNK21.01202790
47EPHA31.00997316
48PIK3CG1.00535078
49KSR20.99920876
50MAPK130.99059527
51PKN10.98480963
52TAOK30.98057410
53MARK20.98055432
54TBK10.97697240
55PLK20.97293952
56FRK0.96124788
57MAP3K30.95169729
58SGK30.94626797
59TEC0.94407631
60MYLK0.93886824
61YES10.92220900
62JAK30.91231158
63GRK70.90673591
64MAP3K140.89510217
65MAPKAPK50.88875550
66CAMK10.88041545
67MAP3K40.86723158
68WNK10.85815694
69KIT0.85766207
70JAK20.85360792
71MAPK110.83864742
72MAP3K20.83530386
73TGFBR20.82393224
74NEK60.82308535
75RET0.80378113
76SYK0.79351191
77MAP3K70.79305581
78CDK50.77129825
79MAP3K130.76947885
80PTK2B0.76917636
81CAMK2B0.76833476
82FER0.75497181
83ITK0.74886333
84MELK0.74070418
85TIE10.73882640
86STK100.73466164
87HIPK20.72354193
88CDK30.71239564
89STK110.70943423
90GRK10.69338827
91DAPK30.68501642
92MAPK120.66202099
93JAK10.65965431
94PIK3CA0.64733140
95SGK10.64322935
96PDK10.64283713
97HCK0.63871722
98CAMK1D0.63775993
99CAMK2A0.63198824
100UHMK10.62738325
101MOS0.61881511
102CSK0.61603238
103STK380.60430000
104CAMK40.60333208
105TRPM70.60029778
106INSRR0.59129285
107DMPK0.59094234
108MAP4K10.58587197
109EPHB10.57884197
110ROCK20.57543951
111IKBKB0.57436369
112PDPK10.57147007
113NTRK20.56493324
114CHUK0.56481713
115PAK20.56477348
116PRKD10.56371928
117MAPK150.55539865
118BMPR20.54853020
119LMTK20.54039117
120SIK30.53270419
121FGR0.52525835
122NTRK10.52269913
123STK390.51510076
124MAPK70.51281265
125PRKAA20.51002980
126PRKCE0.50888748
127MAP3K10.50635453
128EIF2AK20.50234252
129PRKD20.50191665
130IRAK10.49959810
131PHKG20.49098129
132PHKG10.49098129
133CAMK1G0.48537243
134* LCK0.47597042
135PRKCH0.46528535
136MTOR0.46009547
137CSF1R0.45971992
138FYN0.45263307
139IKBKE0.44830473
140MAP3K60.44704687
141BTK0.44484326
142PTK20.44358335
143MAP2K40.44049289
144STK160.44015064
145PRKG10.42887252
146MINK10.42708907
147PRKCQ0.42320238
148LYN0.41692212
149RPS6KA20.41281986
150SIK20.41074410
151MAPK40.40995508
152CAMKK10.40974465

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.77378818
2Morphine addiction_Homo sapiens_hsa050322.45424074
3Olfactory transduction_Homo sapiens_hsa047402.23633377
4Circadian entrainment_Homo sapiens_hsa047132.16104512
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07841946
6Glutamatergic synapse_Homo sapiens_hsa047242.01751273
7Long-term potentiation_Homo sapiens_hsa047201.88182308
8Renin secretion_Homo sapiens_hsa049241.87010362
9Amphetamine addiction_Homo sapiens_hsa050311.85226642
10Synaptic vesicle cycle_Homo sapiens_hsa047211.84151543
11Salivary secretion_Homo sapiens_hsa049701.76730783
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.65491914
13Calcium signaling pathway_Homo sapiens_hsa040201.64709119
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58119640
15GABAergic synapse_Homo sapiens_hsa047271.56439373
16Long-term depression_Homo sapiens_hsa047301.55715753
17Staphylococcus aureus infection_Homo sapiens_hsa051501.49864727
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48767434
19Taste transduction_Homo sapiens_hsa047421.48727667
20Allograft rejection_Homo sapiens_hsa053301.44847288
21cAMP signaling pathway_Homo sapiens_hsa040241.44585813
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43740644
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39744357
24Focal adhesion_Homo sapiens_hsa045101.38702876
25Graft-versus-host disease_Homo sapiens_hsa053321.37289295
26Dopaminergic synapse_Homo sapiens_hsa047281.36094339
27Oxytocin signaling pathway_Homo sapiens_hsa049211.35109930
28Cocaine addiction_Homo sapiens_hsa050301.34769531
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.34639358
30Serotonergic synapse_Homo sapiens_hsa047261.34638269
31Gastric acid secretion_Homo sapiens_hsa049711.34617134
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34174817
33Toxoplasmosis_Homo sapiens_hsa051451.32834845
34Other glycan degradation_Homo sapiens_hsa005111.27937770
35Cholinergic synapse_Homo sapiens_hsa047251.27255195
36Renal cell carcinoma_Homo sapiens_hsa052111.27034653
37Insulin secretion_Homo sapiens_hsa049111.26053845
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25136776
39Phototransduction_Homo sapiens_hsa047441.20028864
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20014752
41Chronic myeloid leukemia_Homo sapiens_hsa052201.16857971
42Acute myeloid leukemia_Homo sapiens_hsa052211.16565701
43Type I diabetes mellitus_Homo sapiens_hsa049401.15581710
44Non-small cell lung cancer_Homo sapiens_hsa052231.13581580
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.13007714
46Pancreatic cancer_Homo sapiens_hsa052121.12518361
47Axon guidance_Homo sapiens_hsa043601.12306773
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11513374
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09259789
50ECM-receptor interaction_Homo sapiens_hsa045121.09220449
51TNF signaling pathway_Homo sapiens_hsa046681.09016660
52Influenza A_Homo sapiens_hsa051641.08777635
53Viral myocarditis_Homo sapiens_hsa054161.08246890
54Measles_Homo sapiens_hsa051621.07244202
55Osteoclast differentiation_Homo sapiens_hsa043801.05878605
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05159304
57Sphingolipid metabolism_Homo sapiens_hsa006001.03307771
58VEGF signaling pathway_Homo sapiens_hsa043701.02979585
59Asthma_Homo sapiens_hsa053101.02653778
60Phagosome_Homo sapiens_hsa041451.01148039
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99858137
62Chemokine signaling pathway_Homo sapiens_hsa040620.99520458
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99224303
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.98540025
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98512909
66Collecting duct acid secretion_Homo sapiens_hsa049660.98240005
67B cell receptor signaling pathway_Homo sapiens_hsa046620.98162718
68MAPK signaling pathway_Homo sapiens_hsa040100.95955635
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95582568
70Hepatitis B_Homo sapiens_hsa051610.94978567
71Platelet activation_Homo sapiens_hsa046110.94967276
72Prolactin signaling pathway_Homo sapiens_hsa049170.94428263
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93386859
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93321499
75Primary immunodeficiency_Homo sapiens_hsa053400.93035153
76GnRH signaling pathway_Homo sapiens_hsa049120.92615754
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.92243617
78mTOR signaling pathway_Homo sapiens_hsa041500.91497072
79Proteoglycans in cancer_Homo sapiens_hsa052050.91459407
80Amoebiasis_Homo sapiens_hsa051460.89118848
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88598094
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87741691
83Hepatitis C_Homo sapiens_hsa051600.86407009
84Small cell lung cancer_Homo sapiens_hsa052220.85459622
85ErbB signaling pathway_Homo sapiens_hsa040120.85399828
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85001030
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84596030
88Leishmaniasis_Homo sapiens_hsa051400.84346234
89Ras signaling pathway_Homo sapiens_hsa040140.82830798
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.82715620
91Hematopoietic cell lineage_Homo sapiens_hsa046400.82695135
92Rheumatoid arthritis_Homo sapiens_hsa053230.82516211
93Endometrial cancer_Homo sapiens_hsa052130.82042510
94Dorso-ventral axis formation_Homo sapiens_hsa043200.81795780
95Gap junction_Homo sapiens_hsa045400.80820853
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80076166
97Tuberculosis_Homo sapiens_hsa051520.79531518
98Dilated cardiomyopathy_Homo sapiens_hsa054140.78360201
99Ovarian steroidogenesis_Homo sapiens_hsa049130.78347521
100Inositol phosphate metabolism_Homo sapiens_hsa005620.78329212
101Prostate cancer_Homo sapiens_hsa052150.76821482
102Insulin resistance_Homo sapiens_hsa049310.76553323
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.75828407
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74784551
105Adherens junction_Homo sapiens_hsa045200.74457390
106Complement and coagulation cascades_Homo sapiens_hsa046100.73088859
107Choline metabolism in cancer_Homo sapiens_hsa052310.73053161
108Autoimmune thyroid disease_Homo sapiens_hsa053200.71813503
109Vibrio cholerae infection_Homo sapiens_hsa051100.71623096
110Apoptosis_Homo sapiens_hsa042100.71157428
111FoxO signaling pathway_Homo sapiens_hsa040680.71137188
112Malaria_Homo sapiens_hsa051440.70906531
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.70679137
114T cell receptor signaling pathway_Homo sapiens_hsa046600.70648776
115HIF-1 signaling pathway_Homo sapiens_hsa040660.70431946
116Melanogenesis_Homo sapiens_hsa049160.69161494
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68455293
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68319940
119Antigen processing and presentation_Homo sapiens_hsa046120.68086100
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66787744
121Estrogen signaling pathway_Homo sapiens_hsa049150.66392563
122Pertussis_Homo sapiens_hsa051330.65905284
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65496787
124Type II diabetes mellitus_Homo sapiens_hsa049300.65193101
125Glioma_Homo sapiens_hsa052140.64952939
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64459458
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63022496
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.61694107
129Rap1 signaling pathway_Homo sapiens_hsa040150.61370705
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60285567
131Herpes simplex infection_Homo sapiens_hsa051680.59771447
132Circadian rhythm_Homo sapiens_hsa047100.59152345
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59104185
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58147078
135African trypanosomiasis_Homo sapiens_hsa051430.57254584
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56734261
137Lysosome_Homo sapiens_hsa041420.56502147
138Thyroid hormone synthesis_Homo sapiens_hsa049180.56126044
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54123862
140Endocytosis_Homo sapiens_hsa041440.52596842
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.52403192
142Salmonella infection_Homo sapiens_hsa051320.51812555
143Ether lipid metabolism_Homo sapiens_hsa005650.50783047
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.50375907
145Pancreatic secretion_Homo sapiens_hsa049720.50074842

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