TACC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.96819004
2mitotic metaphase plate congression (GO:0007080)5.38509531
3protein localization to chromosome, centromeric region (GO:0071459)5.30523426
4mitotic sister chromatid segregation (GO:0000070)5.21917820
5mitotic chromosome condensation (GO:0007076)5.14667863
6kinetochore organization (GO:0051383)4.95053852
7DNA unwinding involved in DNA replication (GO:0006268)4.88110370
8sister chromatid segregation (GO:0000819)4.85797634
9attachment of spindle microtubules to kinetochore (GO:0008608)4.79092923
10metaphase plate congression (GO:0051310)4.77582915
11DNA strand elongation involved in DNA replication (GO:0006271)4.75117486
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.67740411
13regulation of spindle organization (GO:0090224)4.67395341
14CENP-A containing nucleosome assembly (GO:0034080)4.60114400
15establishment of chromosome localization (GO:0051303)4.56915378
16DNA replication initiation (GO:0006270)4.55454236
17DNA strand elongation (GO:0022616)4.50971845
18chromatin remodeling at centromere (GO:0031055)4.49256220
19mitotic nuclear envelope disassembly (GO:0007077)4.41297355
20telomere maintenance via semi-conservative replication (GO:0032201)4.37980627
21kinetochore assembly (GO:0051382)4.29855164
22DNA replication checkpoint (GO:0000076)4.20880640
23DNA replication-independent nucleosome assembly (GO:0006336)4.16003628
24DNA replication-independent nucleosome organization (GO:0034724)4.16003628
25nuclear pore organization (GO:0006999)4.10160312
26nuclear envelope disassembly (GO:0051081)4.09291861
27membrane disassembly (GO:0030397)4.09291861
28DNA replication-dependent nucleosome assembly (GO:0006335)4.09098076
29DNA replication-dependent nucleosome organization (GO:0034723)4.09098076
30positive regulation of chromosome segregation (GO:0051984)4.07856177
31mitotic recombination (GO:0006312)4.06529620
32telomere maintenance via recombination (GO:0000722)4.05370471
33regulation of mitotic spindle organization (GO:0060236)4.03060988
34spindle checkpoint (GO:0031577)4.02816278
35meiotic chromosome segregation (GO:0045132)3.97002915
36regulation of chromosome segregation (GO:0051983)3.93702878
37nuclear pore complex assembly (GO:0051292)3.93404369
38histone exchange (GO:0043486)3.91100556
39protein localization to chromosome (GO:0034502)3.87074838
40negative regulation of chromosome segregation (GO:0051985)3.82491829
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.81927549
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.81927549
43positive regulation of mitotic sister chromatid separation (GO:1901970)3.81927549
44spindle assembly checkpoint (GO:0071173)3.80864057
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.79115726
46negative regulation of sister chromatid segregation (GO:0033046)3.79115726
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.79115726
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.79115726
49mitotic spindle assembly checkpoint (GO:0007094)3.73356481
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.72503633
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.71602519
52chromosome segregation (GO:0007059)3.69631001
53mitotic spindle checkpoint (GO:0071174)3.67035240
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.66848248
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.66385742
56telomere maintenance via telomere lengthening (GO:0010833)3.63209034
57regulation of sister chromatid segregation (GO:0033045)3.57508608
58regulation of mitotic sister chromatid separation (GO:0010965)3.57508608
59regulation of mitotic sister chromatid segregation (GO:0033047)3.57508608
60nucleobase biosynthetic process (GO:0046112)3.57339253
61regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.56619320
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.47921429
63chromosome condensation (GO:0030261)3.47371591
64regulation of centrosome cycle (GO:0046605)3.43031117
65formation of translation preinitiation complex (GO:0001731)3.42349431
66regulation of histone H3-K9 methylation (GO:0051570)3.40057839
67chromatin assembly or disassembly (GO:0006333)3.35072866
68negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.34347574
69regulation of sister chromatid cohesion (GO:0007063)3.34090102
70IMP biosynthetic process (GO:0006188)3.31945718
71DNA duplex unwinding (GO:0032508)3.29911183
72DNA geometric change (GO:0032392)3.29810218
73DNA synthesis involved in DNA repair (GO:0000731)3.28734942
74heterochromatin organization (GO:0070828)3.27152012
75purine nucleobase biosynthetic process (GO:0009113)3.26955962
76ATP-dependent chromatin remodeling (GO:0043044)3.21225332
77histone-serine phosphorylation (GO:0035404)3.20554467
78negative regulation of histone methylation (GO:0031061)3.19907902
79nuclear envelope organization (GO:0006998)3.19580619
80maturation of SSU-rRNA (GO:0030490)3.16920907
81DNA topological change (GO:0006265)3.16899387
823-UTR-mediated mRNA stabilization (GO:0070935)3.15850493
83mitotic sister chromatid cohesion (GO:0007064)3.13634039
84mitotic cell cycle (GO:0000278)3.13625498
85DNA packaging (GO:0006323)3.13268264
86spliceosomal tri-snRNP complex assembly (GO:0000244)3.13092717
87DNA conformation change (GO:0071103)3.12042157
88microtubule depolymerization (GO:0007019)3.11445547
89folic acid-containing compound biosynthetic process (GO:0009396)3.10708377
90pore complex assembly (GO:0046931)3.10000199
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09528650
92protein K6-linked ubiquitination (GO:0085020)3.05965568
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.03845621
94negative regulation of mitosis (GO:0045839)3.03391279
95IMP metabolic process (GO:0046040)3.02892056
96negative regulation of erythrocyte differentiation (GO:0045647)3.02859221
97regulation of RNA export from nucleus (GO:0046831)3.01254936
98regulation of exit from mitosis (GO:0007096)3.00704410
99ribosome assembly (GO:0042255)3.00240564
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99238190
101somatic hypermutation of immunoglobulin genes (GO:0016446)2.99238190
102establishment of integrated proviral latency (GO:0075713)2.96805488
103telomere maintenance (GO:0000723)2.93441751
104regulation of centriole replication (GO:0046599)2.92108736
105telomere organization (GO:0032200)2.92042729
106ribosomal small subunit assembly (GO:0000028)2.91544866
107mismatch repair (GO:0006298)2.90518982
108regulation of chromatin binding (GO:0035561)2.89869248
109RNA stabilization (GO:0043489)2.87631014
110mRNA stabilization (GO:0048255)2.87631014
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85619226
112protein-DNA complex disassembly (GO:0032986)2.82815693
113nucleosome disassembly (GO:0006337)2.82815693
114negative regulation of mRNA processing (GO:0050686)2.82491626
115ribosome biogenesis (GO:0042254)2.81634303
116ribosomal small subunit biogenesis (GO:0042274)2.81040906
117negative regulation of mRNA metabolic process (GO:1903312)2.79492782
118G1/S transition of mitotic cell cycle (GO:0000082)2.78651808
119DNA ligation (GO:0006266)2.77194517
120chromatin assembly (GO:0031497)2.70114824
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69288309
122positive regulation of gamma-delta T cell activation (GO:0046645)2.69011746
123regulation of translational fidelity (GO:0006450)2.65900916
124histone H3-K36 demethylation (GO:0070544)2.63744374
125negative regulation of RNA splicing (GO:0033119)2.62601441
126V(D)J recombination (GO:0033151)2.61966932
127intracellular estrogen receptor signaling pathway (GO:0030520)2.58081411
128pentose-phosphate shunt (GO:0006098)2.54672206
129base-excision repair (GO:0006284)2.53482639
130dosage compensation (GO:0007549)2.52631614
131regulation of histone H3-K4 methylation (GO:0051569)2.50708415
132regulation of nucleobase-containing compound transport (GO:0032239)2.49205477
133histone phosphorylation (GO:0016572)2.48787479
134protein export from nucleus (GO:0006611)2.48218199
135viral mRNA export from host cell nucleus (GO:0046784)2.45354951
136protein complex localization (GO:0031503)2.43759677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.74272868
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.62727175
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.48464379
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.17050080
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.86927487
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37998479
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95786156
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75534633
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72181163
10* AR_21909140_ChIP-Seq_LNCAP_Human2.69999189
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63485353
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.62147239
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49959045
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39434740
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.37620794
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36052282
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.31258194
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.27001631
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26534267
20XRN2_22483619_ChIP-Seq_HELA_Human2.23345014
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.16159668
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13762073
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08100698
24* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07807311
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02210581
26* VDR_23849224_ChIP-Seq_CD4+_Human1.94441989
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85926715
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81539331
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.80046119
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79645186
31DCP1A_22483619_ChIP-Seq_HELA_Human1.79520059
32TTF2_22483619_ChIP-Seq_HELA_Human1.72334204
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72322590
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68812375
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68018937
36GABP_19822575_ChIP-Seq_HepG2_Human1.66923862
37CIITA_25753668_ChIP-Seq_RAJI_Human1.66645206
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62575578
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62004111
40TCF7_22412390_ChIP-Seq_EML_Mouse1.57059221
41MAF_26560356_Chip-Seq_TH1_Human1.56278625
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55615381
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55566395
44* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55518053
45MYC_22102868_ChIP-Seq_BL_Human1.55366537
46ELK1_19687146_ChIP-ChIP_HELA_Human1.54338423
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52089542
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51794218
49UTX_26944678_Chip-Seq_JUKART_Human1.51375823
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50162992
51* VDR_24763502_ChIP-Seq_THP-1_Human1.48193519
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45290030
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44268699
54KDM5A_27292631_Chip-Seq_BREAST_Human1.41777051
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40612066
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39322573
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36091015
58* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35388940
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.35281521
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33570619
61* MAF_26560356_Chip-Seq_TH2_Human1.32891409
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32664750
63* RUNX1_22412390_ChIP-Seq_EML_Mouse1.31970616
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29979967
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28404152
66KDM2B_26808549_Chip-Seq_DND41_Human1.28347068
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27963074
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25129645
69LXR_22292898_ChIP-Seq_THP-1_Human1.24824191
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23747114
71SCL_19346495_ChIP-Seq_HPC-7_Human1.23453718
72NCOR1_26117541_ChIP-Seq_K562_Human1.23407019
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.23385668
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22694420
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21191056
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19867314
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19691762
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17726869
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17379610
80MYB_26560356_Chip-Seq_TH1_Human1.16759371
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16394787
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15595501
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13656513
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11967286
85* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09986845
86MYB_26560356_Chip-Seq_TH2_Human1.09932606
87* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09662312
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08902808
89* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08661606
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08526331
91TFEB_21752829_ChIP-Seq_HELA_Human1.07373598
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07349514
93* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06206780
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05844756
95RACK7_27058665_Chip-Seq_MCF-7_Human1.05828884
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05055636
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04508202
98* SRF_21415370_ChIP-Seq_HL-1_Mouse1.03592602
99P68_20966046_ChIP-Seq_HELA_Human1.02327420
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00827971
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00206784
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98151080
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98059462
104* VDR_21846776_ChIP-Seq_THP-1_Human0.96922641
105GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95072825
106MYC_18940864_ChIP-ChIP_HL60_Human0.94758428
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94351754
108TET1_21451524_ChIP-Seq_MESCs_Mouse0.93662291
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93514711
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.93241609
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.92588013
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92449855
113* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91897204
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91651967
115* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86830150
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86724397
117* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86232378
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83487228
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82788600
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82714410
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80846301
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79762310
123* SPI1_23547873_ChIP-Seq_NB4_Human0.79538381
124* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.74155921
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73763829
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73519241
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73251418
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72022440
129* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71763405
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.67024189
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.65269485
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64635823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61563694
2MP0003111_abnormal_nucleus_morphology5.03082607
3MP0010094_abnormal_chromosome_stability5.02977718
4MP0004957_abnormal_blastocyst_morpholog4.42502566
5* MP0003077_abnormal_cell_cycle4.28726849
6MP0008057_abnormal_DNA_replication3.96056204
7MP0008058_abnormal_DNA_repair3.13460280
8MP0008007_abnormal_cellular_replicative2.95096717
9MP0008932_abnormal_embryonic_tissue2.81310141
10MP0001730_embryonic_growth_arrest2.49678828
11MP0003123_paternal_imprinting2.39883659
12MP0000350_abnormal_cell_proliferation2.33986866
13MP0008877_abnormal_DNA_methylation2.25956841
14MP0010352_gastrointestinal_tract_polyps2.13922060
15MP0010307_abnormal_tumor_latency2.06772844
16MP0002396_abnormal_hematopoietic_system2.03077309
17MP0003718_maternal_effect1.97440534
18MP0005451_abnormal_body_composition1.96848336
19MP0010030_abnormal_orbit_morphology1.87893567
20MP0003436_decreased_susceptibility_to1.87451282
21* MP0001672_abnormal_embryogenesis/_devel1.82442751
22* MP0005380_embryogenesis_phenotype1.82442751
23* MP0001697_abnormal_embryo_size1.79339339
24MP0002877_abnormal_melanocyte_morpholog1.76823654
25MP0008260_abnormal_autophagy1.76496857
26MP0003786_premature_aging1.73563179
27MP0005464_abnormal_platelet_physiology1.70309210
28MP0004185_abnormal_adipocyte_glucose1.69501451
29* MP0002085_abnormal_embryonic_tissue1.64545120
30* MP0002080_prenatal_lethality1.62711587
31MP0001835_abnormal_antigen_presentation1.60759822
32* MP0003984_embryonic_growth_retardation1.58918598
33MP0003121_genomic_imprinting1.57793044
34MP0000490_abnormal_crypts_of1.55418174
35* MP0002088_abnormal_embryonic_growth/wei1.54706059
36MP0002084_abnormal_developmental_patter1.52048153
37MP0005076_abnormal_cell_differentiation1.52003335
38MP0003303_peritoneal_inflammation1.47530842
39MP0000313_abnormal_cell_death1.46214557
40MP0000685_abnormal_immune_system1.44819115
41MP0002086_abnormal_extraembryonic_tissu1.44085534
42MP0002019_abnormal_tumor_incidence1.43395129
43MP0004197_abnormal_fetal_growth/weight/1.39802098
44MP0002420_abnormal_adaptive_immunity1.37595218
45MP0001819_abnormal_immune_cell1.35592836
46MP0002210_abnormal_sex_determination1.31875377
47MP0001800_abnormal_humoral_immune1.30518254
48* MP0004808_abnormal_hematopoietic_stem1.27524842
49MP0005000_abnormal_immune_tolerance1.24136795
50MP0003567_abnormal_fetal_cardiomyocyte1.22232650
51MP0009053_abnormal_anal_canal1.22190884
52MP0002452_abnormal_antigen_presenting1.18896425
53MP0002419_abnormal_innate_immunity1.17964455
54MP0006054_spinal_hemorrhage1.17751376
55MP0003315_abnormal_perineum_morphology1.17206646
56MP0002723_abnormal_immune_serum1.16482419
57MP0001929_abnormal_gametogenesis1.16197104
58MP0005025_abnormal_response_to1.12429188
59MP0001145_abnormal_male_reproductive1.11635327
60MP0003705_abnormal_hypodermis_morpholog1.11134577
61MP0004947_skin_inflammation1.09889542
62MP0003300_gastrointestinal_ulcer1.09480175
63MP0003890_abnormal_embryonic-extraembry1.08180584
64MP0004233_abnormal_muscle_weight1.07481090
65MP0002405_respiratory_system_inflammati1.05698733
66MP0001293_anophthalmia1.04576388
67MP0000653_abnormal_sex_gland1.02765858
68MP0005397_hematopoietic_system_phenotyp1.01224053
69MP0001545_abnormal_hematopoietic_system1.01224053
70MP0003937_abnormal_limbs/digits/tail_de1.00965623
71MP0003656_abnormal_erythrocyte_physiolo1.00843587
72MP0000678_abnormal_parathyroid_gland1.00819562
73MP0005501_abnormal_skin_physiology1.00584909
74MP0001119_abnormal_female_reproductive1.00117004
75MP0009333_abnormal_splenocyte_physiolog0.99796660
76MP0005058_abnormal_lysosome_morphology0.98882661
77* MP0000703_abnormal_thymus_morphology0.97667304
78MP0000537_abnormal_urethra_morphology0.96448478
79MP0005671_abnormal_response_to0.95255634
80MP0002132_abnormal_respiratory_system0.92022812
81MP0005023_abnormal_wound_healing0.89777599
82MP0001790_abnormal_immune_system0.89546300
83MP0005387_immune_system_phenotype0.89546300
84* MP0002398_abnormal_bone_marrow0.89380060
85MP0001873_stomach_inflammation0.88811490
86MP0006035_abnormal_mitochondrial_morpho0.86340998
87MP0003763_abnormal_thymus_physiology0.86253373
88MP0009672_abnormal_birth_weight0.85822632
89MP0003119_abnormal_digestive_system0.84902227
90MP0003191_abnormal_cellular_cholesterol0.84833400
91MP0002009_preneoplasia0.84136070
92* MP0002722_abnormal_immune_system0.83368482
93MP0001915_intracranial_hemorrhage0.83244647
94MP0002166_altered_tumor_susceptibility0.82596259
95* MP0002111_abnormal_tail_morphology0.81255370
96MP0001853_heart_inflammation0.80853051
97MP0003453_abnormal_keratinocyte_physiol0.80540501
98MP0005384_cellular_phenotype0.80513202
99MP0005621_abnormal_cell_physiology0.80311750
100MP0000858_altered_metastatic_potential0.78505090
101MP0003806_abnormal_nucleotide_metabolis0.78451972
102MP0000689_abnormal_spleen_morphology0.78385489
103MP0005389_reproductive_system_phenotype0.78299836
104MP0009278_abnormal_bone_marrow0.78128769
105MP0000428_abnormal_craniofacial_morphol0.75546388
106MP0003943_abnormal_hepatobiliary_system0.74694007
107MP0002160_abnormal_reproductive_system0.74177480
108MP0010155_abnormal_intestine_physiology0.73759088
109MP0002796_impaired_skin_barrier0.70867257
110MP0003941_abnormal_skin_development0.70281765
111MP0003699_abnormal_female_reproductive0.69940578
112MP0003566_abnormal_cell_adhesion0.69111438
113MP0001849_ear_inflammation0.68110809
114* MP0002429_abnormal_blood_cell0.67969903
115MP0009703_decreased_birth_body0.67240591
116MP0000566_synostosis0.67185568
117MP0002089_abnormal_postnatal_growth/wei0.67134913
118MP0000465_gastrointestinal_hemorrhage0.66897055
119MP0001919_abnormal_reproductive_system0.66373953
120MP0000358_abnormal_cell_content/0.65922137
121MP0003115_abnormal_respiratory_system0.65476410
122MP0005075_abnormal_melanosome_morpholog0.64830190
123MP0002092_abnormal_eye_morphology0.63765975
124MP0003221_abnormal_cardiomyocyte_apopto0.63618740
125MP0000733_abnormal_muscle_development0.63120633
126MP0001286_abnormal_eye_development0.61230273
127MP0002161_abnormal_fertility/fecundity0.58738123
128MP0004133_heterotaxia0.58021504
129MP0000477_abnormal_intestine_morphology0.57088602
130MP0004264_abnormal_extraembryonic_tissu0.56441411
131* MP0000432_abnormal_head_morphology0.55630440
132MP0003935_abnormal_craniofacial_develop0.55148040
133MP0002925_abnormal_cardiovascular_devel0.55117151
134MP0002653_abnormal_ependyma_morphology0.54886594
135MP0002282_abnormal_trachea_morphology0.54844047
136MP0002102_abnormal_ear_morphology0.53335916
137MP0006292_abnormal_olfactory_placode0.52895569
138MP0003755_abnormal_palate_morphology0.51641237
139MP0005395_other_phenotype0.50985903
140MP0000049_abnormal_middle_ear0.50982415
141* MP0000716_abnormal_immune_system0.50650379
142* MP0002932_abnormal_joint_morphology0.49804445

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.46120384
2Birth length less than 3rd percentile (HP:0003561)4.30728307
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.24712591
4Reticulocytopenia (HP:0001896)3.57944902
5Breast hypoplasia (HP:0003187)3.57490161
6Patellar aplasia (HP:0006443)3.53410910
7Abnormality of chromosome stability (HP:0003220)3.50444138
8Meckel diverticulum (HP:0002245)3.45649839
9Carpal bone hypoplasia (HP:0001498)3.38171983
10Aplasia/Hypoplasia of the patella (HP:0006498)3.30378525
11Selective tooth agenesis (HP:0001592)3.30364674
12Abnormality of the ileum (HP:0001549)3.28985599
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.24886500
14Abnormality of the preputium (HP:0100587)3.24569129
15Duodenal stenosis (HP:0100867)3.24413761
16Small intestinal stenosis (HP:0012848)3.24413761
17Colon cancer (HP:0003003)3.21832801
18Increased nuchal translucency (HP:0010880)3.08856516
19Medulloblastoma (HP:0002885)3.00928637
20Abnormality of the anterior horn cell (HP:0006802)2.98252417
21Degeneration of anterior horn cells (HP:0002398)2.98252417
22Impulsivity (HP:0100710)2.96031763
23Absent radius (HP:0003974)2.93014772
24Cellulitis (HP:0100658)2.88471618
25Abnormal lung lobation (HP:0002101)2.86061985
26Oral leukoplakia (HP:0002745)2.85519356
27Myelodysplasia (HP:0002863)2.85099809
28Ectopic kidney (HP:0000086)2.81044397
29Ependymoma (HP:0002888)2.79270311
30Progressive muscle weakness (HP:0003323)2.75365763
31Aplasia involving forearm bones (HP:0009822)2.72916573
32Absent forearm bone (HP:0003953)2.72916573
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.66447001
34Absent thumb (HP:0009777)2.64626546
35Abnormality of the duodenum (HP:0002246)2.63810967
36Sloping forehead (HP:0000340)2.63802127
37Recurrent viral infections (HP:0004429)2.63685232
38Recurrent abscess formation (HP:0002722)2.62285064
3911 pairs of ribs (HP:0000878)2.57896313
40Agnosia (HP:0010524)2.57894559
41Rhabdomyosarcoma (HP:0002859)2.56887063
42Eczematoid dermatitis (HP:0000976)2.54251594
43Progressive external ophthalmoplegia (HP:0000590)2.50263692
44Abnormality of the fingertips (HP:0001211)2.49509910
45Bone marrow hypocellularity (HP:0005528)2.45794138
46Panhypogammaglobulinemia (HP:0003139)2.42355572
47Chronic obstructive pulmonary disease (HP:0006510)2.41819891
48Obstructive lung disease (HP:0006536)2.41819891
49Nephroblastoma (Wilms tumor) (HP:0002667)2.41133144
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39724819
51Deviation of the thumb (HP:0009603)2.39047281
52Abnormality of the labia minora (HP:0012880)2.38896672
53Proximal placement of thumb (HP:0009623)2.38241041
54Hyperacusis (HP:0010780)2.37717599
55Abnormality of the carotid arteries (HP:0005344)2.37317811
56Aplastic anemia (HP:0001915)2.36855361
57Short 4th metacarpal (HP:0010044)2.36298599
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36298599
59Metaphyseal cupping (HP:0003021)2.33977017
60Duplicated collecting system (HP:0000081)2.32684232
61Prolonged bleeding time (HP:0003010)2.31233282
62Neoplasm of the pancreas (HP:0002894)2.31139862
63Rough bone trabeculation (HP:0100670)2.30592558
64Recurrent bacterial skin infections (HP:0005406)2.29679482
65Microvesicular hepatic steatosis (HP:0001414)2.28172007
66Abnormality of cells of the erythroid lineage (HP:0012130)2.26740817
67Abnormal number of incisors (HP:0011064)2.26346267
68Cafe-au-lait spot (HP:0000957)2.26312032
69Embryonal renal neoplasm (HP:0011794)2.25655995
70Gastrointestinal inflammation (HP:0004386)2.24398915
71Abnormal platelet volume (HP:0011876)2.22958250
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.22556315
73Atresia of the external auditory canal (HP:0000413)2.21973687
74Abnormal number of erythroid precursors (HP:0012131)2.21152160
75Premature ovarian failure (HP:0008209)2.20698219
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.19243476
77Abnormal gallbladder physiology (HP:0012438)2.18906811
78Cholecystitis (HP:0001082)2.18906811
79Tracheoesophageal fistula (HP:0002575)2.18333292
80Volvulus (HP:0002580)2.17052069
81Ragged-red muscle fibers (HP:0003200)2.16481949
82Horseshoe kidney (HP:0000085)2.16302637
83High anterior hairline (HP:0009890)2.14010596
84Triphalangeal thumb (HP:0001199)2.13817518
85High pitched voice (HP:0001620)2.13737606
86Short thumb (HP:0009778)2.12769017
87Viral hepatitis (HP:0006562)2.12550321
88Meningitis (HP:0001287)2.12317361
89Premature graying of hair (HP:0002216)2.10490585
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.09414893
91Agammaglobulinemia (HP:0004432)2.07969405
92Abnormality of reticulocytes (HP:0004312)2.07143739
93Long palpebral fissure (HP:0000637)2.05226840
94Thrombocytosis (HP:0001894)2.04787631
95Absent epiphyses (HP:0010577)2.03467491
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03467491
97Deep palmar crease (HP:0006191)2.03190790
98Abnormality of macrophages (HP:0004311)2.02991364
99Hypergonadotropic hypogonadism (HP:0000815)2.02892502
100Basal cell carcinoma (HP:0002671)2.01952826
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01683741
102Recurrent fungal infections (HP:0002841)2.01640307
103Abnormality of the renal collecting system (HP:0004742)2.01497139
104Neoplasm of the colon (HP:0100273)2.00961961
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.99003004
106Missing ribs (HP:0000921)1.98598216
107Acute lymphatic leukemia (HP:0006721)1.97870959
108Clubbing of toes (HP:0100760)1.97489505
109Supernumerary spleens (HP:0009799)1.97069943
110Facial hemangioma (HP:0000329)1.94710581
111Abnormality of the calcaneus (HP:0008364)1.94267832
112Abnormality of cells of the lymphoid lineage (HP:0012140)1.93806146
113Increased IgE level (HP:0003212)1.93643912
114Poikiloderma (HP:0001029)1.92037869
115Colitis (HP:0002583)1.90358748
116Disproportionate tall stature (HP:0001519)1.89457564
117Hypertensive crisis (HP:0100735)1.88912772
118Flared metaphyses (HP:0003015)1.88851702
119Squamous cell carcinoma (HP:0002860)1.88436873
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.88326997
121Petechiae (HP:0000967)1.87728965
122Inflammation of the large intestine (HP:0002037)1.87451703
123Neoplasm of striated muscle (HP:0009728)1.87181707
124Microretrognathia (HP:0000308)1.87155197
125Trismus (HP:0000211)1.86663714
126Abnormality of DNA repair (HP:0003254)1.86004698
127Reticulocytosis (HP:0001923)1.84681458
128Lymphopenia (HP:0001888)1.84105614
129Cellular immunodeficiency (HP:0005374)1.83808667
130Fatigue (HP:0012378)1.83725323
131Osteomyelitis (HP:0002754)1.82531249
132Slender long bone (HP:0003100)1.80783415
133Increased mean platelet volume (HP:0011877)1.79895398
134Cerebral hypomyelination (HP:0006808)1.79558642
135Abnormality of abdominal situs (HP:0011620)1.78034902
136Abdominal situs inversus (HP:0003363)1.78034902
137Astrocytoma (HP:0009592)1.77885251
138Abnormality of the astrocytes (HP:0100707)1.77885251
139Prominent nose (HP:0000448)1.77797914
140Abnormality of T cell physiology (HP:0011840)1.77527917
141Urethral obstruction (HP:0000796)1.76936216
142Aplasia/hypoplasia of the humerus (HP:0006507)1.76790797
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76720649
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.76649017
145Combined immunodeficiency (HP:0005387)1.74994014
146Glioma (HP:0009733)1.74981409
147Irregular epiphyses (HP:0010582)1.74766480
148Lymphoma (HP:0002665)1.74550954
149Abnormality of the proximal phalanges of the hand (HP:0009834)1.74268679
150Increased connective tissue (HP:0009025)1.74153087
151Pallor (HP:0000980)1.73965016
152Ovarian neoplasm (HP:0100615)1.73709970
153Broad distal phalanx of finger (HP:0009836)1.72492588
154IgM deficiency (HP:0002850)1.72082246
155Secondary amenorrhea (HP:0000869)1.71756271
156Abnormality of chromosome segregation (HP:0002916)1.71004634
157Cleft eyelid (HP:0000625)1.70924568
158Abnormality of the columella (HP:0009929)1.69531302
159Overlapping toe (HP:0001845)1.69071793
160Long eyelashes (HP:0000527)1.68917830
161Abnormality of the thoracic spine (HP:0100711)1.67849875
162Mediastinal lymphadenopathy (HP:0100721)1.67573806
163Multiple enchondromatosis (HP:0005701)1.67175909
164Deep philtrum (HP:0002002)1.66915105
165Uterine leiomyosarcoma (HP:0002891)1.66801389
166Leiomyosarcoma (HP:0100243)1.66801389
167Urticaria (HP:0001025)1.65922028
168Hepatosplenomegaly (HP:0001433)1.65539458
169Epistaxis (HP:0000421)1.65248436
170Abnormality of the thymus (HP:0000777)1.64603904
171Recurrent cutaneous fungal infections (HP:0011370)1.63413907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.05681203
2CDC74.41174427
3WEE14.10419506
4SMG13.71312355
5NEK23.39066887
6BRSK23.06102788
7TTK3.05369660
8NEK12.72462451
9EIF2AK12.56756876
10PRPF4B2.43734839
11BRSK12.38994765
12PLK12.34783201
13PLK42.26658416
14STK102.06978338
15AURKB2.03623838
16SRPK11.97199877
17ERN11.90062377
18TESK21.83878489
19VRK21.83220604
20PLK31.82721795
21RIPK41.79040927
22CCNB11.78307028
23ACVR1B1.74448681
24CHEK21.68840385
25CDK121.68610058
26MAP3K81.66140256
27ATR1.64525296
28TSSK61.63723221
29ICK1.56190345
30PASK1.56046010
31CDK71.54633347
32MKNK11.48880641
33EEF2K1.46667055
34MAP3K131.46550290
35VRK11.44767844
36STK41.41955791
37CDK41.39853743
38RPS6KA41.38374398
39MELK1.35608451
40TLK11.34304713
41RPS6KB21.32499386
42CHEK11.30351311
43IRAK41.29415780
44IRAK31.29367661
45* AURKA1.28077441
46EIF2AK31.15225853
47PAK41.09366676
48DYRK31.08160670
49MAP3K101.05288970
50SIK11.00673071
51TESK10.99384147
52TAF10.98913464
53ZAK0.98734744
54NME20.93284585
55PBK0.91725958
56TGFBR10.90957639
57ATM0.89510570
58MKNK20.88294913
59SIK20.86146436
60BMX0.85050603
61BRAF0.84431335
62KSR20.83514663
63ARAF0.82431739
64* CDK20.82141976
65EPHA20.80357968
66SCYL20.78716786
67CDK80.78518944
68MAP3K140.78207962
69CDK60.78067350
70STK30.77592022
71JAK30.76748406
72STK160.75962178
73CSF1R0.75343204
74FGFR40.74467028
75CDK10.72413684
76LRRK20.71663140
77PAK10.70695376
78PTK60.70485622
79ZAP700.67991754
80FES0.67803492
81PIM10.67582565
82EIF2AK20.65909985
83CLK10.65665208
84BRD40.63148492
85PKN20.60224085
86MARK30.59969825
87SIK30.59879159
88CDK190.59203489
89MAP4K10.56865424
90TAOK10.55493770
91TYK20.54928972
92MAP3K10.53694983
93TNK20.53644831
94IRAK20.52411932
95KDR0.51326118
96CSNK2A10.51051156
97HCK0.49302874
98MAP2K20.49082165
99STK38L0.48664354
100FGR0.47083558
101CSNK2A20.46552595
102RAF10.46211985
103EPHB10.44956218
104ALK0.44286591
105MAP3K50.42957259
106CAMK1D0.42425588
107MAP3K30.39097697
108LIMK10.36900045
109MTOR0.36578303
110PRKCI0.36188504
111AKT20.35271576
112MAP2K30.33587573
113RPS6KA50.32779489
114LATS20.31786991
115MAPKAPK20.28816047
116PRKDC0.28652832
117BTK0.28302902
118FLT30.27554947
119MAPKAPK30.27094708
120MAP3K110.26250133
121TTN0.25762388
122FGFR10.24224793
123ILK0.22051203
124MAPK110.21580136
125AKT10.20518461
126CDK90.20314487
127* MAPK140.19892300
128TRIB30.19404282
129PAK20.19221019
130CSNK1E0.18863120
131NEK90.18514588
132PDK30.17657518
133PDK40.17657518
134LATS10.17294560
135GRK60.17127443
136CDK11A0.16658915
137TAOK20.16355342

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.23962239
2Mismatch repair_Homo sapiens_hsa034304.40654102
3Cell cycle_Homo sapiens_hsa041103.49963674
4Base excision repair_Homo sapiens_hsa034103.35695875
5Homologous recombination_Homo sapiens_hsa034403.32470450
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30327877
7Spliceosome_Homo sapiens_hsa030403.23639238
8* RNA transport_Homo sapiens_hsa030133.10945197
9Nucleotide excision repair_Homo sapiens_hsa034202.92081390
10Proteasome_Homo sapiens_hsa030502.71130413
11Fanconi anemia pathway_Homo sapiens_hsa034602.63088703
12RNA polymerase_Homo sapiens_hsa030202.62117083
13One carbon pool by folate_Homo sapiens_hsa006702.49830898
14Ribosome_Homo sapiens_hsa030102.39011864
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35635116
16Non-homologous end-joining_Homo sapiens_hsa034502.33778370
17Pyrimidine metabolism_Homo sapiens_hsa002402.17661119
18Basal transcription factors_Homo sapiens_hsa030221.93466474
19p53 signaling pathway_Homo sapiens_hsa041151.93338965
20RNA degradation_Homo sapiens_hsa030181.93144489
21Acute myeloid leukemia_Homo sapiens_hsa052211.91834680
22mRNA surveillance pathway_Homo sapiens_hsa030151.86114357
23B cell receptor signaling pathway_Homo sapiens_hsa046621.66761272
24Systemic lupus erythematosus_Homo sapiens_hsa053221.46064171
25Oocyte meiosis_Homo sapiens_hsa041141.46034058
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39302668
27Epstein-Barr virus infection_Homo sapiens_hsa051691.21643707
28Viral carcinogenesis_Homo sapiens_hsa052031.17790815
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12509377
30Purine metabolism_Homo sapiens_hsa002301.12416372
31Osteoclast differentiation_Homo sapiens_hsa043801.06859836
32Leishmaniasis_Homo sapiens_hsa051401.05005008
33T cell receptor signaling pathway_Homo sapiens_hsa046600.99944465
34Endometrial cancer_Homo sapiens_hsa052130.98512603
35MicroRNAs in cancer_Homo sapiens_hsa052060.98407858
36HTLV-I infection_Homo sapiens_hsa051660.94862115
37Herpes simplex infection_Homo sapiens_hsa051680.93556961
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89405177
39Antigen processing and presentation_Homo sapiens_hsa046120.85567169
40Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82572490
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82201170
42Small cell lung cancer_Homo sapiens_hsa052220.81120216
43Other glycan degradation_Homo sapiens_hsa005110.76083258
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75263015
45VEGF signaling pathway_Homo sapiens_hsa043700.72658430
46Renal cell carcinoma_Homo sapiens_hsa052110.72445781
47Pentose phosphate pathway_Homo sapiens_hsa000300.72198913
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72006596
49Vitamin B6 metabolism_Homo sapiens_hsa007500.68918102
50Selenocompound metabolism_Homo sapiens_hsa004500.68296712
51Biosynthesis of amino acids_Homo sapiens_hsa012300.67912759
52Toxoplasmosis_Homo sapiens_hsa051450.66442226
53Thyroid cancer_Homo sapiens_hsa052160.65183930
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.64905710
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.62631160
56Galactose metabolism_Homo sapiens_hsa000520.60318501
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60309400
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59900466
59Colorectal cancer_Homo sapiens_hsa052100.59111128
60Hippo signaling pathway_Homo sapiens_hsa043900.58676896
61Legionellosis_Homo sapiens_hsa051340.56767889
62Basal cell carcinoma_Homo sapiens_hsa052170.56765648
63Hepatitis C_Homo sapiens_hsa051600.56643462
64Glioma_Homo sapiens_hsa052140.55669347
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55059310
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53974294
67Apoptosis_Homo sapiens_hsa042100.53692605
68Tuberculosis_Homo sapiens_hsa051520.52763558
69ErbB signaling pathway_Homo sapiens_hsa040120.52408606
70TGF-beta signaling pathway_Homo sapiens_hsa043500.52330951
71Alcoholism_Homo sapiens_hsa050340.51647847
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.51081825
73Notch signaling pathway_Homo sapiens_hsa043300.49011673
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48328664
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48106037
76Bladder cancer_Homo sapiens_hsa052190.48103142
77Hepatitis B_Homo sapiens_hsa051610.47533259
78Platelet activation_Homo sapiens_hsa046110.46769390
79Chronic myeloid leukemia_Homo sapiens_hsa052200.46498645
80Shigellosis_Homo sapiens_hsa051310.45756497
81TNF signaling pathway_Homo sapiens_hsa046680.45559498
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.45101004
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45012123
84Primary immunodeficiency_Homo sapiens_hsa053400.44617768
85Chemokine signaling pathway_Homo sapiens_hsa040620.44473266
86Inositol phosphate metabolism_Homo sapiens_hsa005620.42514315
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41783673
88Glutathione metabolism_Homo sapiens_hsa004800.40735911
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40439402
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39437752
91Hedgehog signaling pathway_Homo sapiens_hsa043400.37237031
92Adherens junction_Homo sapiens_hsa045200.37215796
93Folate biosynthesis_Homo sapiens_hsa007900.36874151
94Viral myocarditis_Homo sapiens_hsa054160.36807188
95Pancreatic cancer_Homo sapiens_hsa052120.34891415
96N-Glycan biosynthesis_Homo sapiens_hsa005100.32962791
97Pathways in cancer_Homo sapiens_hsa052000.32813970
98Carbon metabolism_Homo sapiens_hsa012000.32707884
99Measles_Homo sapiens_hsa051620.32116311
100HIF-1 signaling pathway_Homo sapiens_hsa040660.28800247
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.27644071
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26780648
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.26619233
104Influenza A_Homo sapiens_hsa051640.24940332
105Protein export_Homo sapiens_hsa030600.24172127
106Prostate cancer_Homo sapiens_hsa052150.24126739
107mTOR signaling pathway_Homo sapiens_hsa041500.23019243
108Non-small cell lung cancer_Homo sapiens_hsa052230.22938468
109FoxO signaling pathway_Homo sapiens_hsa040680.20633608
110Lysine degradation_Homo sapiens_hsa003100.20236037
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18857531
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.18169320
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17381834
114Proteoglycans in cancer_Homo sapiens_hsa052050.17340683
115Hematopoietic cell lineage_Homo sapiens_hsa046400.17016769
116Huntingtons disease_Homo sapiens_hsa050160.16157282
117Fructose and mannose metabolism_Homo sapiens_hsa000510.15228048
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13791881
119Sulfur relay system_Homo sapiens_hsa041220.13602504
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12367787
121Renin-angiotensin system_Homo sapiens_hsa046140.11773005
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11304300
123Wnt signaling pathway_Homo sapiens_hsa043100.11222824
124Melanoma_Homo sapiens_hsa052180.11006079
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10724496
126Tight junction_Homo sapiens_hsa045300.10652269

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