TACO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.86870546
2lysine catabolic process (GO:0006554)5.86870546
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.47146240
4L-phenylalanine catabolic process (GO:0006559)5.47146240
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.42016991
6L-phenylalanine metabolic process (GO:0006558)5.42016991
7kynurenine metabolic process (GO:0070189)5.26436326
8glyoxylate metabolic process (GO:0046487)5.18666820
9aromatic amino acid family catabolic process (GO:0009074)5.06053907
102-oxoglutarate metabolic process (GO:0006103)5.03372372
11proline biosynthetic process (GO:0006561)4.93637788
12tricarboxylic acid cycle (GO:0006099)4.93132153
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82297217
14alpha-linolenic acid metabolic process (GO:0036109)4.77868413
15ribosomal small subunit biogenesis (GO:0042274)4.76994078
16indole-containing compound catabolic process (GO:0042436)4.76580769
17indolalkylamine catabolic process (GO:0046218)4.76580769
18tryptophan catabolic process (GO:0006569)4.76580769
19fatty acid transmembrane transport (GO:1902001)4.75838196
20maturation of SSU-rRNA (GO:0030490)4.74977829
21carnitine shuttle (GO:0006853)4.73724572
22aspartate family amino acid catabolic process (GO:0009068)4.67077597
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.64261178
24fatty acid beta-oxidation (GO:0006635)4.60592037
25tryptophan metabolic process (GO:0006568)4.58117276
26amino-acid betaine metabolic process (GO:0006577)4.49548165
27acetyl-CoA metabolic process (GO:0006084)4.49153879
28serine family amino acid catabolic process (GO:0009071)4.44470054
29urea cycle (GO:0000050)4.42771474
30urea metabolic process (GO:0019627)4.42771474
31cellular ketone body metabolic process (GO:0046950)4.41441813
32dicarboxylic acid biosynthetic process (GO:0043650)4.32638830
33bile acid biosynthetic process (GO:0006699)4.32457731
34regulation of triglyceride catabolic process (GO:0010896)4.32082954
35peptidyl-arginine omega-N-methylation (GO:0035247)4.24927311
36glycine metabolic process (GO:0006544)4.22423884
37negative regulation of fatty acid biosynthetic process (GO:0045717)4.17929031
38fatty acid oxidation (GO:0019395)4.17492757
39oxaloacetate metabolic process (GO:0006107)4.16349920
40regulation of mitochondrial translation (GO:0070129)4.16013628
41cysteine metabolic process (GO:0006534)4.14920736
42NADH metabolic process (GO:0006734)4.11208133
43fatty acid catabolic process (GO:0009062)4.10180427
44lipid oxidation (GO:0034440)4.10162359
45nitrogen cycle metabolic process (GO:0071941)4.06989070
46alpha-amino acid catabolic process (GO:1901606)4.06231469
47carnitine metabolic process (GO:0009437)4.01822500
48short-chain fatty acid metabolic process (GO:0046459)3.99691007
49ethanol oxidation (GO:0006069)3.97237878
50monocarboxylic acid catabolic process (GO:0072329)3.94927544
51valine metabolic process (GO:0006573)3.91533183
52sarcomere organization (GO:0045214)3.91086638
53sulfur amino acid catabolic process (GO:0000098)3.90578565
54negative regulation of fibrinolysis (GO:0051918)3.88751772
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.84052584
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.81341997
57homocysteine metabolic process (GO:0050667)3.80512222
58ketone body metabolic process (GO:1902224)3.80162945
59branched-chain amino acid catabolic process (GO:0009083)3.78329988
60serine family amino acid metabolic process (GO:0009069)3.78164703
61aromatic amino acid family metabolic process (GO:0009072)3.76556544
62tricarboxylic acid metabolic process (GO:0072350)3.76011165
63cellular amino acid catabolic process (GO:0009063)3.74915412
64regulation of protein activation cascade (GO:2000257)3.74837021
65serine family amino acid biosynthetic process (GO:0009070)3.74746388
66regulation of sequestering of triglyceride (GO:0010889)3.73156797
67complement activation, alternative pathway (GO:0006957)3.72353958
68negative regulation of fatty acid metabolic process (GO:0045922)3.72338608
69pseudouridine synthesis (GO:0001522)3.72191473
70proline metabolic process (GO:0006560)3.67255127
71positive regulation of fatty acid beta-oxidation (GO:0032000)3.65688405
72carnitine transmembrane transport (GO:1902603)3.63218343
73histone arginine methylation (GO:0034969)3.62909245
74organic acid catabolic process (GO:0016054)3.62416201
75carboxylic acid catabolic process (GO:0046395)3.62416201
76protein maturation by protein folding (GO:0022417)3.61264288
77regulation of fatty acid oxidation (GO:0046320)3.61252599
78branched-chain amino acid metabolic process (GO:0009081)3.58959547
79ribosome biogenesis (GO:0042254)3.57461753
80high-density lipoprotein particle remodeling (GO:0034375)3.57317303
81carnitine transport (GO:0015879)3.56437977
82amino-acid betaine transport (GO:0015838)3.56437977
83phospholipid homeostasis (GO:0055091)3.55826085
84ribonucleoprotein complex biogenesis (GO:0022613)3.52713917
85protein carboxylation (GO:0018214)3.51601831
86peptidyl-glutamic acid carboxylation (GO:0017187)3.51601831
87regulation of fibrinolysis (GO:0051917)3.51373576
88regulation of complement activation (GO:0030449)3.50362977
89cellular modified amino acid catabolic process (GO:0042219)3.49232333
90succinate metabolic process (GO:0006105)3.47863074
91bile acid metabolic process (GO:0008206)3.47640848
92peptidyl-arginine N-methylation (GO:0035246)3.47354440
93peptidyl-arginine methylation (GO:0018216)3.47354440
94formation of translation preinitiation complex (GO:0001731)3.46862620
95L-serine metabolic process (GO:0006563)3.45323760
96rRNA transcription (GO:0009303)3.44473701
97oxidative phosphorylation (GO:0006119)3.43735327
98glutamate metabolic process (GO:0006536)3.43656286
99regulation of acyl-CoA biosynthetic process (GO:0050812)3.42308370
100tyrosine metabolic process (GO:0006570)3.41767565
101regulation of translational fidelity (GO:0006450)3.41403489
102acylglycerol homeostasis (GO:0055090)3.40536603
103triglyceride homeostasis (GO:0070328)3.40536603
104fatty acid homeostasis (GO:0055089)3.40294855
105biotin metabolic process (GO:0006768)3.39277375
106UTP biosynthetic process (GO:0006228)3.38432055
107coenzyme catabolic process (GO:0009109)3.36841283
108mitochondrial fusion (GO:0008053)3.34418066
109regulation of fatty acid beta-oxidation (GO:0031998)3.34359197
110pyrimidine nucleoside catabolic process (GO:0046135)3.32125857
111proteasome assembly (GO:0043248)3.31535349
112plasma lipoprotein particle clearance (GO:0034381)3.31039672
113plasma lipoprotein particle remodeling (GO:0034369)3.30668733
114protein-lipid complex remodeling (GO:0034368)3.30668733
115macromolecular complex remodeling (GO:0034367)3.30668733
116nucleobase-containing small molecule interconversion (GO:0015949)3.29873918
117actin-myosin filament sliding (GO:0033275)3.28553207
118muscle filament sliding (GO:0030049)3.28553207
119positive regulation of lipid catabolic process (GO:0050996)3.28292000
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26972134
121guanosine-containing compound biosynthetic process (GO:1901070)3.26961051
122indolalkylamine metabolic process (GO:0006586)3.25943192
123positive regulation of fatty acid oxidation (GO:0046321)3.25824548
124regulation of cholesterol esterification (GO:0010872)3.23693227
125negative regulation of cholesterol transport (GO:0032375)3.23534149
126mitotic nuclear envelope reassembly (GO:0007084)3.23505974
127nuclear envelope reassembly (GO:0031468)3.23505974
128DNA strand elongation involved in DNA replication (GO:0006271)3.22924970
129DNA strand elongation (GO:0022616)3.21469443
130pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.20630367
131DNA unwinding involved in DNA replication (GO:0006268)3.20106715
132GDP-mannose metabolic process (GO:0019673)3.18950709
133GTP biosynthetic process (GO:0006183)3.18704621
134UTP metabolic process (GO:0046051)3.17952356
135tRNA methylation (GO:0030488)3.16921927
136protein targeting to mitochondrion (GO:0006626)3.16537107
137regulation of translational termination (GO:0006449)3.15365864
138pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.13915128
139pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.12422666
140pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.08760044
141spliceosomal snRNP assembly (GO:0000387)3.07399155
142gluconeogenesis (GO:0006094)3.03056010
143establishment of protein localization to mitochondrion (GO:0072655)3.02723616
144cellular component biogenesis (GO:0044085)2.99758840
145transcription from mitochondrial promoter (GO:0006390)2.97761583
146negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97165143
147spliceosomal tri-snRNP complex assembly (GO:0000244)2.97121438
148viral transcription (GO:0019083)2.96995605
149mitochondrial RNA metabolic process (GO:0000959)2.96287856
150regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96220285
151pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.95231424
152monosaccharide biosynthetic process (GO:0046364)2.94989842
153viral mRNA export from host cell nucleus (GO:0046784)2.94878456
154CTP metabolic process (GO:0046036)2.93089384
155CTP biosynthetic process (GO:0006241)2.93089384
156establishment of protein localization to mitochondrial membrane (GO:0090151)2.91982505
157rRNA processing (GO:0006364)2.91486355
158folic acid metabolic process (GO:0046655)2.88896508
159hexose biosynthetic process (GO:0019319)2.87872903
160DNA replication checkpoint (GO:0000076)2.86908936
161protein localization to mitochondrion (GO:0070585)2.86534790
162translational elongation (GO:0006414)2.85863169
163mitotic chromosome condensation (GO:0007076)2.85709987
164negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82599665
165pentose metabolic process (GO:0019321)2.80836918
166telomere maintenance via semi-conservative replication (GO:0032201)2.80413488
167translational termination (GO:0006415)2.79437951
168ribosome assembly (GO:0042255)2.76521236
169rRNA metabolic process (GO:0016072)2.73557556
170rRNA modification (GO:0000154)2.72748766
171translation (GO:0006412)2.72037541
172establishment of integrated proviral latency (GO:0075713)2.70608099
173pteridine-containing compound biosynthetic process (GO:0042559)2.69450981
174pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.69091112
175Golgi transport vesicle coating (GO:0048200)2.66541464
176COPI coating of Golgi vesicle (GO:0048205)2.66541464
177mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66189549
178negative regulation of ligase activity (GO:0051352)2.65993223
179negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65993223
180folic acid-containing compound biosynthetic process (GO:0009396)2.64642205
181IMP biosynthetic process (GO:0006188)2.63501989
182anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62033011
183purine nucleobase biosynthetic process (GO:0009113)2.61941551
184negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.61239200
185tRNA modification (GO:0006400)2.61162375
186nucleobase biosynthetic process (GO:0046112)2.61034154
187nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59287692
188ribosomal large subunit biogenesis (GO:0042273)2.59075699
189pentose-phosphate shunt (GO:0006098)2.58878173
190iron-sulfur cluster assembly (GO:0016226)2.58693147
191metallo-sulfur cluster assembly (GO:0031163)2.58693147
192SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58157299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.29512353
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.70932857
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.09646095
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.73844880
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.69022806
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.32082818
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.65174845
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.62743109
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.61019553
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.54291467
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.29504530
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.78190597
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53369258
14* XRN2_22483619_ChIP-Seq_HELA_Human2.52894822
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.50977927
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.45259260
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32467707
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21892238
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18542226
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16717952
21* DCP1A_22483619_ChIP-Seq_HELA_Human2.16285074
22GABP_19822575_ChIP-Seq_HepG2_Human2.08775619
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.08552455
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.06942914
25CLOCK_20551151_ChIP-Seq_293T_Human2.01223772
26* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96396507
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92021161
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90519450
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85501281
30TTF2_22483619_ChIP-Seq_HELA_Human1.74180142
31ZNF263_19887448_ChIP-Seq_K562_Human1.72938642
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.72869469
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70192931
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67546822
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64663677
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64347386
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.59636787
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59241562
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57943652
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57686249
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.57504394
42* FOXM1_23109430_ChIP-Seq_U2OS_Human1.57347875
43KDM5A_27292631_Chip-Seq_BREAST_Human1.52916388
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52587792
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51175021
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47409433
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.46569771
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.46569771
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45411269
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36564523
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35218461
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34953274
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.34818945
54E2F7_22180533_ChIP-Seq_HELA_Human1.34468286
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31998767
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30047772
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29622117
58* FOXP3_21729870_ChIP-Seq_TREG_Human1.28982795
59AR_21909140_ChIP-Seq_LNCAP_Human1.28888084
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27222643
61GATA1_22025678_ChIP-Seq_K562_Human1.25932226
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23806481
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23653873
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21425668
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20684035
66FOXP1_21924763_ChIP-Seq_HESCs_Human1.19167294
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18566018
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18333205
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18304260
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17640936
71* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17405725
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16887398
73* VDR_23849224_ChIP-Seq_CD4+_Human1.16694597
74HNF4A_19822575_ChIP-Seq_HepG2_Human1.15929117
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.14817334
76GATA4_21415370_ChIP-Seq_HL-1_Mouse1.13306161
77TBX5_21415370_ChIP-Seq_HL-1_Mouse1.12844075
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12589813
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12365315
80* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12197893
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11841928
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11815947
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11508284
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10977377
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.09320752
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09116902
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07301831
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06825485
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06515203
90TFEB_21752829_ChIP-Seq_HELA_Human1.04632313
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04627126
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01383416
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00714098
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98356934
95* RARA_24833708_ChIP-Seq_LIVER_Mouse0.98054957
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96730305
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96412608
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95776339
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95522233
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94350798
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94270864
102MYC_22102868_ChIP-Seq_BL_Human0.93784677
103MYC_18555785_ChIP-Seq_MESCs_Mouse0.91393475
104MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84896025
105RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83426530
106SRF_21415370_ChIP-Seq_HL-1_Mouse0.83271803
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81835326
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81821186
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81760749
110LXR_22292898_ChIP-Seq_THP-1_Human0.80554368
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80286237
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79791089
113BCOR_27268052_Chip-Seq_Bcells_Human0.79734720
114NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78908378
115HTT_18923047_ChIP-ChIP_STHdh_Human0.78647455
116ATF3_27146783_Chip-Seq_COLON_Human0.78639483
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.76572563
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76301980
119BCL6_27268052_Chip-Seq_Bcells_Human0.75331116
120SPI1_20517297_ChIP-Seq_HL60_Human0.75309426
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.73622170
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72330779
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.72319569
124VDR_21846776_ChIP-Seq_THP-1_Human0.70384406
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69762720
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.68816807
127GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68671764
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.67883455
129JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.67450001
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66334291
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66223592
132MYC_19030024_ChIP-ChIP_MESCs_Mouse0.66135262
133CEBPB_22108803_ChIP-Seq_LS180_Human0.65938605
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.65433975
135CIITA_25753668_ChIP-Seq_RAJI_Human0.64666449
136P68_20966046_ChIP-Seq_HELA_Human0.64356709
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.63863769
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.63136460
139RACK7_27058665_Chip-Seq_MCF-7_Human0.63129914
140ETS1_20019798_ChIP-Seq_JURKAT_Human0.63079545
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63067413
142GATA1_19941826_ChIP-Seq_K562_Human0.62551788
143GATA4_25053715_ChIP-Seq_YYC3_Human0.62206154
144MAF_26560356_Chip-Seq_TH1_Human0.61990573
145GATA6_25053715_ChIP-Seq_YYC3_Human0.61866811
146PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.60994637
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.59904780
148AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59895643
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.59697268
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.59261958
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.59251950
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.59052677
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.59052000
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.59010322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.72110182
2MP0005360_urolithiasis5.63599975
3MP0005085_abnormal_gallbladder_physiolo4.58210490
4MP0003806_abnormal_nucleotide_metabolis4.25963106
5MP0005365_abnormal_bile_salt4.25543616
6MP0003693_abnormal_embryo_hatching4.23940841
7MP0002837_dystrophic_cardiac_calcinosis4.19143694
8MP0003646_muscle_fatigue3.65289018
9MP0003111_abnormal_nucleus_morphology3.28980738
10MP0008875_abnormal_xenobiotic_pharmacok3.14577190
11MP0010094_abnormal_chromosome_stability2.94735766
12MP0004084_abnormal_cardiac_muscle2.75796315
13MP0003252_abnormal_bile_duct2.71738384
14MP0010329_abnormal_lipoprotein_level2.56319509
15MP0009840_abnormal_foam_cell2.52519718
16MP0005332_abnormal_amino_acid2.48366086
17MP0000751_myopathy2.47345121
18MP0004957_abnormal_blastocyst_morpholog2.41459220
19MP0005058_abnormal_lysosome_morphology2.39678201
20MP0005330_cardiomyopathy2.33384320
21MP0000749_muscle_degeneration2.31839116
22MP0004036_abnormal_muscle_relaxation2.30074993
23MP0004130_abnormal_muscle_cell2.27858930
24MP0005083_abnormal_biliary_tract2.24689452
25MP0003077_abnormal_cell_cycle2.20596912
26MP0004215_abnormal_myocardial_fiber2.17324962
27MP0006036_abnormal_mitochondrial_physio2.16388935
28MP0008058_abnormal_DNA_repair2.07812970
29MP0008932_abnormal_embryonic_tissue2.06668002
30MP0008007_abnormal_cellular_replicative1.95055743
31MP0003195_calcinosis1.90504853
32MP0004087_abnormal_muscle_fiber1.89300689
33MP0008260_abnormal_autophagy1.89054092
34MP0002269_muscular_atrophy1.85256914
35MP0000609_abnormal_liver_physiology1.79076723
36MP0005319_abnormal_enzyme/_coenzyme1.78966676
37MP0003705_abnormal_hypodermis_morpholog1.78122962
38MP0003786_premature_aging1.75304865
39MP0001661_extended_life_span1.75046527
40MP0005501_abnormal_skin_physiology1.73892242
41MP0005670_abnormal_white_adipose1.68148904
42MP0002653_abnormal_ependyma_morphology1.67050064
43MP0004858_abnormal_nervous_system1.66710272
44MP0002118_abnormal_lipid_homeostasis1.64605172
45MP0003191_abnormal_cellular_cholesterol1.61052128
46MP0001666_abnormal_nutrient_absorption1.60538814
47MP0000678_abnormal_parathyroid_gland1.56186715
48MP0001730_embryonic_growth_arrest1.55889563
49MP0008775_abnormal_heart_ventricle1.55720147
50MP0005666_abnormal_adipose_tissue1.55417129
51MP0010630_abnormal_cardiac_muscle1.54709496
52MP0003656_abnormal_erythrocyte_physiolo1.53879733
53MP0002163_abnormal_gland_morphology1.51782306
54MP0002972_abnormal_cardiac_muscle1.51202427
55MP0005584_abnormal_enzyme/coenzyme_acti1.49571074
56MP0001544_abnormal_cardiovascular_syste1.47165645
57MP0005385_cardiovascular_system_phenoty1.47165645
58MP0000747_muscle_weakness1.44661840
59MP0003221_abnormal_cardiomyocyte_apopto1.44355280
60MP0001727_abnormal_embryo_implantation1.44028964
61MP0010234_abnormal_vibrissa_follicle1.43996004
62MP0006035_abnormal_mitochondrial_morpho1.41271156
63MP0002796_impaired_skin_barrier1.41114140
64MP0005620_abnormal_muscle_contractility1.40645539
65MP0002106_abnormal_muscle_physiology1.34919798
66MP0000750_abnormal_muscle_regeneration1.31768090
67MP0000003_abnormal_adipose_tissue1.31587245
68MP0003137_abnormal_impulse_conducting1.31384196
69MP0000350_abnormal_cell_proliferation1.31300135
70MP0002138_abnormal_hepatobiliary_system1.28467819
71MP0004147_increased_porphyrin_level1.24655871
72MP0004019_abnormal_vitamin_homeostasis1.24293443
73MP0003186_abnormal_redox_activity1.23917401
74MP0001764_abnormal_homeostasis1.21555659
75MP0005623_abnormal_meninges_morphology1.16199959
76MP0009643_abnormal_urine_homeostasis1.16007653
77MP0006138_congestive_heart_failure1.14904200
78MP0010030_abnormal_orbit_morphology1.14759163
79MP0005266_abnormal_metabolism1.13885178
80MP0002080_prenatal_lethality1.13564839
81MP0000313_abnormal_cell_death1.12136298
82MP0009333_abnormal_splenocyte_physiolog1.11989353
83MP0003315_abnormal_perineum_morphology1.11707293
84MP0002877_abnormal_melanocyte_morpholog1.11654307
85MP0000759_abnormal_skeletal_muscle1.11182920
86MP0003718_maternal_effect1.08731741
87MP0000598_abnormal_liver_morphology1.03920377
88MP0005451_abnormal_body_composition1.03005000
89MP0001881_abnormal_mammary_gland1.03001579
90MP0005369_muscle_phenotype1.02256965
91MP0002971_abnormal_brown_adipose1.01398184
92MP0001697_abnormal_embryo_size0.98313505
93MP0004185_abnormal_adipocyte_glucose0.96435416
94MP0003123_paternal_imprinting0.96195277
95MP0004145_abnormal_muscle_electrophysio0.95690379
96MP0000013_abnormal_adipose_tissue0.94206480
97MP0001672_abnormal_embryogenesis/_devel0.92467727
98MP0005380_embryogenesis_phenotype0.92467727
99MP0009697_abnormal_copulation0.91019383
100MP0009379_abnormal_foot_pigmentation0.90652119
101MP0005375_adipose_tissue_phenotype0.89972957
102MP0009053_abnormal_anal_canal0.89414828
103MP0004484_altered_response_of0.89276006
104MP0004233_abnormal_muscle_weight0.86767499
105MP0005076_abnormal_cell_differentiation0.86675402
106MP0002078_abnormal_glucose_homeostasis0.86613183
107MP0002332_abnormal_exercise_endurance0.84568547
108MP0003984_embryonic_growth_retardation0.82931470
109MP0001873_stomach_inflammation0.81704405
110MP0003136_yellow_coat_color0.81534203
111MP0002249_abnormal_larynx_morphology0.79048139
112MP0005376_homeostasis/metabolism_phenot0.78383666
113MP0003567_abnormal_fetal_cardiomyocyte0.77996399
114MP0001853_heart_inflammation0.77860725
115MP0005379_endocrine/exocrine_gland_phen0.77695306
116MP0000733_abnormal_muscle_development0.77448373
117MP0001346_abnormal_lacrimal_gland0.76608301
118MP0002088_abnormal_embryonic_growth/wei0.76096312
119MP0009763_increased_sensitivity_to0.74302398
120MP0009384_cardiac_valve_regurgitation0.72055596
121MP0002234_abnormal_pharynx_morphology0.69887459
122MP0002089_abnormal_postnatal_growth/wei0.69727082
123MP0009642_abnormal_blood_homeostasis0.69058644
124MP0002127_abnormal_cardiovascular_syste0.68037589
125MP0001529_abnormal_vocalization0.68026974
126MP0005334_abnormal_fat_pad0.68021231
127MP0008469_abnormal_protein_level0.67192094
128MP0002160_abnormal_reproductive_system0.66652549
129MP0004085_abnormal_heartbeat0.65893625
130MP0002085_abnormal_embryonic_tissue0.65495160
131MP0002822_catalepsy0.64512099
132MP0010368_abnormal_lymphatic_system0.64050559
133MP0003828_pulmonary_edema0.64003410
134MP0000266_abnormal_heart_morphology0.63724237
135MP0005535_abnormal_body_temperature0.63518856
136MP0003941_abnormal_skin_development0.62972730
137MP0005636_abnormal_mineral_homeostasis0.62820746
138MP0000490_abnormal_crypts_of0.62438442
139MP0003868_abnormal_feces_composition0.62425105
140MP0001756_abnormal_urination0.61043849
141MP0009780_abnormal_chondrocyte_physiolo0.60622945
142MP0003011_delayed_dark_adaptation0.59004297
143MP0000343_altered_response_to0.57262549
144MP0002970_abnormal_white_adipose0.55988313
145MP0004510_myositis0.55483727
146MP0000604_amyloidosis0.55344393
147MP0009764_decreased_sensitivity_to0.54441172
148MP0009672_abnormal_birth_weight0.52683171
149MP0002128_abnormal_blood_circulation0.51216596
150MP0009115_abnormal_fat_cell0.47606095
151MP0000230_abnormal_systemic_arterial0.46803453
152MP0000249_abnormal_blood_vessel0.42929402
153MP0000358_abnormal_cell_content/0.42671043
154MP0005165_increased_susceptibility_to0.42155101
155MP0004043_abnormal_pH_regulation0.41303426
156MP0003566_abnormal_cell_adhesion0.40109666

Predicted human phenotypes

RankGene SetZ-score
1Hyperammonemia (HP:0001987)4.50562571
2Deep venous thrombosis (HP:0002625)4.49036275
3Myoglobinuria (HP:0002913)4.47935276
4Hypobetalipoproteinemia (HP:0003563)4.39139231
5Intrahepatic cholestasis (HP:0001406)4.32255446
6Hypoglycemic coma (HP:0001325)4.29895236
7Progressive muscle weakness (HP:0003323)4.26315285
8Exercise-induced muscle cramps (HP:0003710)4.21901765
9Hyperglycinuria (HP:0003108)4.19332802
10Ketosis (HP:0001946)4.11284624
11Xanthomatosis (HP:0000991)4.10335006
12Abnormality of monocarboxylic acid metabolism (HP:0010996)4.07837820
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.05625789
14Exercise-induced myalgia (HP:0003738)4.01153856
15Abnormality of fatty-acid metabolism (HP:0004359)4.00889484
16Abnormality of glycine metabolism (HP:0010895)3.91984870
17Abnormality of serine family amino acid metabolism (HP:0010894)3.91984870
18Ketoacidosis (HP:0001993)3.83752277
19Rhabdomyolysis (HP:0003201)3.82531545
20Sudden death (HP:0001699)3.82054194
21Hypolipoproteinemia (HP:0010981)3.72574988
22Hyperglycinemia (HP:0002154)3.66458415
23Hyperlipoproteinemia (HP:0010980)3.62015379
24Abnormality of glycolysis (HP:0004366)3.56099740
25Abnormal mitochondria in muscle tissue (HP:0008316)3.52419681
26Hypoalphalipoproteinemia (HP:0003233)3.48698670
27Hypokinesia (HP:0002375)3.45715113
28Increased serum pyruvate (HP:0003542)3.43197907
29Dicarboxylic aciduria (HP:0003215)3.40576421
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.40576421
31Microretrognathia (HP:0000308)3.39247981
32Calf muscle hypertrophy (HP:0008981)3.39167207
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.38556603
34Prolonged partial thromboplastin time (HP:0003645)3.31199311
35Ventricular tachycardia (HP:0004756)3.31064623
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25961044
37Muscle hypertrophy of the lower extremities (HP:0008968)3.22333359
38Complement deficiency (HP:0004431)3.15394192
39Acute necrotizing encephalopathy (HP:0006965)3.11013767
40Cerebral edema (HP:0002181)3.08172938
41Muscle fiber splitting (HP:0003555)3.02238623
42Microvesicular hepatic steatosis (HP:0001414)3.01631566
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98630964
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98630964
45Achilles tendon contracture (HP:0001771)2.95327534
46Hepatic necrosis (HP:0002605)2.93617392
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.92365559
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91409296
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.89100212
50Hyporeflexia of lower limbs (HP:0002600)2.85242558
51Metabolic acidosis (HP:0001942)2.82718226
52Abnormality of serum amino acid levels (HP:0003112)2.81987753
53* Increased intramyocellular lipid droplets (HP:0012240)2.79255107
54Abnormality of pyrimidine metabolism (HP:0004353)2.79003292
55Nemaline bodies (HP:0003798)2.78635357
56Lethargy (HP:0001254)2.77194859
57Abnormality of complement system (HP:0005339)2.76484691
58Abnormality of the Achilles tendon (HP:0005109)2.75727098
59Lipoatrophy (HP:0100578)2.74669197
60Palpitations (HP:0001962)2.73869347
61* Increased CSF lactate (HP:0002490)2.73557822
62Abnormality of methionine metabolism (HP:0010901)2.73287095
63Cholelithiasis (HP:0001081)2.72537163
64Epidermoid cyst (HP:0200040)2.72320657
65Generalized aminoaciduria (HP:0002909)2.70831387
66* Increased serum lactate (HP:0002151)2.69544554
67Right ventricular cardiomyopathy (HP:0011663)2.66683748
68* Mitochondrial inheritance (HP:0001427)2.64955990
69* Exercise intolerance (HP:0003546)2.61300221
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61270656
71Increased connective tissue (HP:0009025)2.60530452
72Opisthotonus (HP:0002179)2.60459022
73Hyperbilirubinemia (HP:0002904)2.60360354
74Myopathic facies (HP:0002058)2.59996320
75Delayed CNS myelination (HP:0002188)2.52130172
76Abnormal number of erythroid precursors (HP:0012131)2.52126224
77Asymmetric septal hypertrophy (HP:0001670)2.52084723
78Abnormal gallbladder morphology (HP:0012437)2.51903544
79Gout (HP:0001997)2.50692553
80Abnormality of the common coagulation pathway (HP:0010990)2.48058226
81Abnormality of cells of the erythroid lineage (HP:0012130)2.46288205
82Abnormality of the left ventricular outflow tract (HP:0011103)2.45394531
83Subaortic stenosis (HP:0001682)2.45394531
84Abnormality of nucleobase metabolism (HP:0010932)2.43527662
85Hepatocellular carcinoma (HP:0001402)2.42975889
86EMG: myopathic abnormalities (HP:0003458)2.41001174
87Reticulocytopenia (HP:0001896)2.40579232
88Trismus (HP:0000211)2.40075452
89Dilated cardiomyopathy (HP:0001644)2.39195672
90Conjugated hyperbilirubinemia (HP:0002908)2.37211416
91Difficulty running (HP:0009046)2.34869900
92Atrial fibrillation (HP:0005110)2.34662880
93Abnormality of the calf musculature (HP:0001430)2.32584277
94Centrally nucleated skeletal muscle fibers (HP:0003687)2.30586606
95Atrioventricular block (HP:0001678)2.29695509
96Testicular atrophy (HP:0000029)2.29613196
97Joint hemorrhage (HP:0005261)2.29469563
98Ragged-red muscle fibers (HP:0003200)2.28170194
99Skin nodule (HP:0200036)2.26485059
100Abnormality of purine metabolism (HP:0004352)2.25789847
101Muscle stiffness (HP:0003552)2.25636704
102Acute encephalopathy (HP:0006846)2.25613480
103Fat malabsorption (HP:0002630)2.24628407
104Athetosis (HP:0002305)2.24380862
105Hepatocellular necrosis (HP:0001404)2.22357105
106Abnormality of reticulocytes (HP:0004312)2.21844092
107Septate vagina (HP:0001153)2.18194046
108Vomiting (HP:0002013)2.17291817
109Nausea (HP:0002018)2.17071328
110Distal lower limb muscle weakness (HP:0009053)2.15575243
111* Increased muscle lipid content (HP:0009058)2.15478273
112Primary atrial arrhythmia (HP:0001692)2.15342170
113Type I transferrin isoform profile (HP:0003642)2.13867168
114Hypercholesterolemia (HP:0003124)2.13492517
115Progressive external ophthalmoplegia (HP:0000590)2.13296401
116Reticulocytosis (HP:0001923)2.12969553
117Proximal tubulopathy (HP:0000114)2.12131978
118Hyperinsulinemic hypoglycemia (HP:0000825)2.12094985
119Abnormality of the umbilical cord (HP:0010881)2.11282239
120Late onset (HP:0003584)2.11234498
121* Lactic acidosis (HP:0003128)2.10981999
122Supraventricular tachycardia (HP:0004755)2.10374754
123Neonatal death (HP:0003811)2.09918326
124Prolonged neonatal jaundice (HP:0006579)2.09069821
125Hyperthyroidism (HP:0000836)2.08292528
126Abnormality of the intrinsic pathway (HP:0010989)2.08044333
127Muscle fiber inclusion bodies (HP:0100299)2.06516208
128Abnormality of the tricuspid valve (HP:0001702)2.06160335
129Supraventricular arrhythmia (HP:0005115)2.05562199
130Progressive macrocephaly (HP:0004481)2.04846127
131Birth length less than 3rd percentile (HP:0003561)2.04620348
132Hypoglycemic seizures (HP:0002173)2.04076703
133* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03771482
134Hypertensive crisis (HP:0100735)2.03330312
135Increased purine levels (HP:0004368)2.01792031
136Hyperuricemia (HP:0002149)2.01792031
137Rough bone trabeculation (HP:0100670)2.01749782
138Ulnar deviation of the wrist (HP:0003049)2.00822929
139Abnormal gallbladder physiology (HP:0012438)2.00551597
140Cholecystitis (HP:0001082)2.00551597
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99264629
142Bundle branch block (HP:0011710)1.98854600
143Unilateral renal agenesis (HP:0000122)1.97584248
144Multiple enchondromatosis (HP:0005701)1.97554853
145Broad distal phalanx of finger (HP:0009836)1.94949191
146Macrocytic anemia (HP:0001972)1.94801272
147Hyperalaninemia (HP:0003348)1.94413600
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94413600
149Abnormality of alanine metabolism (HP:0010916)1.94413600
150Reduced antithrombin III activity (HP:0001976)1.93211574
151Respiratory failure (HP:0002878)1.91646800
152Shoulder girdle muscle weakness (HP:0003547)1.85738933
153Entropion (HP:0000621)1.85677968
154Abnormal protein glycosylation (HP:0012346)1.84859185
155Abnormal glycosylation (HP:0012345)1.84859185
156Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84859185
157Abnormal protein N-linked glycosylation (HP:0012347)1.84859185
158Progressive microcephaly (HP:0000253)1.84710333
159Hypoplastic left heart (HP:0004383)1.79062660
160Back pain (HP:0003418)1.77052939
161Truncus arteriosus (HP:0001660)1.74665094
162Spastic diplegia (HP:0001264)1.74332634
163Abnormality of the gallbladder (HP:0005264)1.71828484
164Microglossia (HP:0000171)1.71270129
165Breast hypoplasia (HP:0003187)1.70642923
166Seborrheic dermatitis (HP:0001051)1.70031553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.20522118
2TTN4.28698128
3PKN24.08663816
4OBSCN3.56733324
5VRK23.48683998
6TRIB33.47211028
7PDK43.24970166
8PDK33.24970166
9NEK13.16897015
10IRAK33.09434187
11PIM23.00775456
12SMG12.84717920
13LMTK22.68534529
14STK162.39938797
15SIK12.29322129
16FGFR42.17145578
17PHKG12.12981833
18PHKG22.12981833
19FLT31.99654657
20PDK21.97008240
21ERN11.88172808
22ARAF1.85081381
23MAP2K31.84275113
24NEK91.81497282
25PBK1.79528716
26CDC71.77447180
27MYLK1.76457819
28EPHA21.73582390
29BUB11.60420419
30MAP3K101.56022141
31MAP3K71.55222444
32ICK1.52964323
33AURKA1.43667875
34TESK21.40869606
35NME11.40574025
36CDK81.37181464
37FGFR31.34205822
38TESK11.22720318
39MAPK111.20151668
40TAF11.16254161
41CSNK1G31.14082336
42CHEK21.12739253
43TYK21.11499482
44SRPK11.08974664
45STK41.08604890
46PINK11.05748463
47MAPK121.05349864
48CDK71.04963649
49MAP4K11.04441706
50BRSK11.02783553
51PTK61.01597706
52PAK41.00828541
53MAPKAPK51.00614741
54CAMK2G0.99581070
55BRAF0.98718495
56EEF2K0.98606495
57PRKD30.95363539
58TAOK20.94540900
59PIK3CG0.94493099
60MAP3K50.93426451
61PIK3CA0.93321434
62MAP2K20.91573569
63LIMK10.90561708
64MUSK0.89578817
65PRKAA10.89413324
66MAP3K30.89021356
67DMPK0.88053005
68INSRR0.88010966
69STK240.79822489
70MAP2K70.79224766
71EIF2AK10.79100279
72PRKAA20.78919953
73VRK10.78615143
74TSSK60.76992873
75MAP2K40.75237068
76MAP3K110.74748032
77PRKCI0.74291685
78TGFBR20.74275724
79CDK40.71278769
80PRPF4B0.70161126
81ZAK0.69055519
82FGFR10.68594291
83CAMK2D0.66967472
84TLK10.66781006
85TIE10.66379285
86CSNK1G20.65526686
87KDR0.64992827
88ILK0.63873705
89GRK60.63616090
90JAK20.61867495
91NME20.61792311
92CSNK1G10.61562937
93CSNK1A1L0.60614853
94ATR0.60505318
95RPS6KA50.60071969
96CSF1R0.59887949
97ABL20.57844690
98DYRK30.57755753
99CAMK2B0.57447733
100PDGFRA0.56769146
101CHEK10.56561167
102JAK10.55578799
103MAP3K80.55134216
104MST1R0.54625020
105STK38L0.54191366
106AKT20.53072570
107SIK30.52709731
108PRKD10.52382356
109CCNB10.52261019
110STK100.51640108
111RPS6KA40.50508153
112PRKACG0.50060326
113PDK10.48333186
114PDPK10.48331914
115ERBB40.48093309
116DAPK10.47283179
117TTK0.47006435
118CDK90.46567797
119CSNK2A20.46496578
120GRK70.45860219
121CSNK2A10.45835419
122MTOR0.44558364
123LRRK20.43106320
124TAOK30.42825983
125MELK0.41722624
126RAF10.40885575
127MAP2K60.40129353
128CDK60.40082345
129MAPKAPK30.39949964
130CDK11A0.39769390
131TBK10.39759270
132WEE10.39081732
133PAK10.38916383
134CDK140.38847282
135MAPKAPK20.38744085
136MAPK40.37573530
137ROCK10.36622197
138DYRK1B0.35207900
139PKN10.34842843
140CSK0.34784576
141MET0.34544397
142SCYL20.34506406
143DAPK30.33993972
144RPS6KB20.31482233
145SGK30.30658509
146RPS6KA60.29712251
147RPS6KC10.29492077
148RPS6KL10.29492077
149PRKACB0.27729968
150ITK0.23014970
151PAK30.22699071
152ALK0.22574008
153CDK120.22162861
154AURKB0.22095227
155WNK40.21805540
156PRKCQ0.21769651
157RET0.21318645
158LATS20.20879067
159PLK10.20850261

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.08250078
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.39208405
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.30903677
4Fatty acid degradation_Homo sapiens_hsa000713.29976342
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.22530632
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.09308813
7Propanoate metabolism_Homo sapiens_hsa006402.98083760
8Ribosome_Homo sapiens_hsa030102.96791446
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93954537
10Arginine biosynthesis_Homo sapiens_hsa002202.76580465
11Nitrogen metabolism_Homo sapiens_hsa009102.69195933
12Fatty acid metabolism_Homo sapiens_hsa012122.50469522
13Tryptophan metabolism_Homo sapiens_hsa003802.48504777
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.47337657
15Carbon metabolism_Homo sapiens_hsa012002.27682378
16Butanoate metabolism_Homo sapiens_hsa006502.23694244
17Base excision repair_Homo sapiens_hsa034102.23363208
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19247180
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13771516
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12382162
21Pyruvate metabolism_Homo sapiens_hsa006202.03516450
22PPAR signaling pathway_Homo sapiens_hsa033201.93288148
23Biosynthesis of amino acids_Homo sapiens_hsa012301.84435617
24Peroxisome_Homo sapiens_hsa041461.83718080
25Mismatch repair_Homo sapiens_hsa034301.82464052
26Spliceosome_Homo sapiens_hsa030401.80785388
27beta-Alanine metabolism_Homo sapiens_hsa004101.76998817
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75011895
29RNA polymerase_Homo sapiens_hsa030201.71680216
30Complement and coagulation cascades_Homo sapiens_hsa046101.69515225
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62332389
32Fatty acid elongation_Homo sapiens_hsa000621.54247196
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.53964866
34Starch and sucrose metabolism_Homo sapiens_hsa005001.52529565
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50876554
36Phenylalanine metabolism_Homo sapiens_hsa003601.47413260
37Homologous recombination_Homo sapiens_hsa034401.43279783
38Nucleotide excision repair_Homo sapiens_hsa034201.37703978
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.32372994
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32056100
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28478638
42RNA transport_Homo sapiens_hsa030131.22445427
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21169678
44Selenocompound metabolism_Homo sapiens_hsa004501.18792252
45Caffeine metabolism_Homo sapiens_hsa002321.17097406
46Tyrosine metabolism_Homo sapiens_hsa003501.15395718
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15331957
48Retinol metabolism_Homo sapiens_hsa008301.10808967
49Chemical carcinogenesis_Homo sapiens_hsa052041.09303888
50Bile secretion_Homo sapiens_hsa049761.06427051
51Histidine metabolism_Homo sapiens_hsa003401.06102519
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05145534
53Lysine degradation_Homo sapiens_hsa003101.05087987
54Arginine and proline metabolism_Homo sapiens_hsa003301.03047770
55Fat digestion and absorption_Homo sapiens_hsa049751.00548259
56One carbon pool by folate_Homo sapiens_hsa006701.00244082
57Fanconi anemia pathway_Homo sapiens_hsa034600.97817503
58Pentose phosphate pathway_Homo sapiens_hsa000300.95931266
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.95156203
60Staphylococcus aureus infection_Homo sapiens_hsa051500.94462035
61Cell cycle_Homo sapiens_hsa041100.92532389
62Fatty acid biosynthesis_Homo sapiens_hsa000610.91933141
63Bladder cancer_Homo sapiens_hsa052190.87101371
64Vitamin B6 metabolism_Homo sapiens_hsa007500.86547825
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85464004
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84785217
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.83821016
68Purine metabolism_Homo sapiens_hsa002300.83113826
69Folate biosynthesis_Homo sapiens_hsa007900.81490285
70Cardiac muscle contraction_Homo sapiens_hsa042600.79491751
71Parkinsons disease_Homo sapiens_hsa050120.79063544
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77573776
73ABC transporters_Homo sapiens_hsa020100.77289094
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77024256
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75921103
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74717406
77Other glycan degradation_Homo sapiens_hsa005110.72913730
78Oxidative phosphorylation_Homo sapiens_hsa001900.69610197
79Sulfur metabolism_Homo sapiens_hsa009200.68489904
80Basal transcription factors_Homo sapiens_hsa030220.67989450
81Vibrio cholerae infection_Homo sapiens_hsa051100.67292657
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.64505680
83Insulin resistance_Homo sapiens_hsa049310.62861619
84Glycerolipid metabolism_Homo sapiens_hsa005610.61189443
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.59374636
86Fructose and mannose metabolism_Homo sapiens_hsa000510.59077179
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57697983
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57472240
89Galactose metabolism_Homo sapiens_hsa000520.55393280
90Metabolic pathways_Homo sapiens_hsa011000.53596952
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53461897
92Alzheimers disease_Homo sapiens_hsa050100.52030203
93N-Glycan biosynthesis_Homo sapiens_hsa005100.49160432
94mRNA surveillance pathway_Homo sapiens_hsa030150.48796501
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48475642
96Dilated cardiomyopathy_Homo sapiens_hsa054140.47668849
97Glucagon signaling pathway_Homo sapiens_hsa049220.46102953
98Glutathione metabolism_Homo sapiens_hsa004800.40921554
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40460362
100RNA degradation_Homo sapiens_hsa030180.37525988
101Epstein-Barr virus infection_Homo sapiens_hsa051690.37143291
102Thyroid cancer_Homo sapiens_hsa052160.35945648
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34309318
104AMPK signaling pathway_Homo sapiens_hsa041520.33063154
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31878127
106Vitamin digestion and absorption_Homo sapiens_hsa049770.31579621
107Huntingtons disease_Homo sapiens_hsa050160.31378639
108Insulin signaling pathway_Homo sapiens_hsa049100.31207106
109Sulfur relay system_Homo sapiens_hsa041220.31010024
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30210638
111Non-homologous end-joining_Homo sapiens_hsa034500.29330972
112Lysosome_Homo sapiens_hsa041420.27922993
113Viral myocarditis_Homo sapiens_hsa054160.26373126
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.25740141
115Steroid biosynthesis_Homo sapiens_hsa001000.23356214
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22411593
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22028506
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15739948
119Prion diseases_Homo sapiens_hsa050200.14169048
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.10785625
121Systemic lupus erythematosus_Homo sapiens_hsa053220.02624226
122Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1368435
123Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1313370
124Regulation of autophagy_Homo sapiens_hsa04140-0.1107007
125alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0747481
126Proteasome_Homo sapiens_hsa03050-0.0522945
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0476857
128DNA replication_Homo sapiens_hsa03030-0.0471207
129Pyrimidine metabolism_Homo sapiens_hsa00240-0.0188934
130Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0144566
131HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0138695
132Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0072691

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