TACR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)8.91130166
2terpenoid biosynthetic process (GO:0016114)7.82071377
3adult feeding behavior (GO:0008343)6.64600714
4negative regulation of osteoblast proliferation (GO:0033689)6.45257633
5retinal metabolic process (GO:0042574)4.99041305
6reflex (GO:0060004)4.75371115
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70969067
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.66702436
9vocalization behavior (GO:0071625)4.66409325
10neurotransmitter-gated ion channel clustering (GO:0072578)4.65171684
11pyrimidine nucleobase catabolic process (GO:0006208)4.56539637
12central nervous system projection neuron axonogenesis (GO:0021952)4.55179680
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.54423678
14response to pheromone (GO:0019236)4.40573025
15behavioral defense response (GO:0002209)4.37499017
16behavioral fear response (GO:0001662)4.37499017
17membrane depolarization during action potential (GO:0086010)4.35379061
18regulation of glutamate receptor signaling pathway (GO:1900449)4.35105404
19negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.22696047
20* positive regulation of vascular permeability (GO:0043117)4.13866550
21* tachykinin receptor signaling pathway (GO:0007217)4.09595099
22synaptic transmission, dopaminergic (GO:0001963)4.02895931
23neuron cell-cell adhesion (GO:0007158)4.02271047
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.00819001
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.00273188
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.97285944
27fear response (GO:0042596)3.95319350
28regulation of timing of cell differentiation (GO:0048505)3.93699144
29regulation of microtubule-based movement (GO:0060632)3.93326448
30cytoplasmic mRNA processing body assembly (GO:0033962)3.90420644
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90051672
32establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.89928661
33mitochondrion transport along microtubule (GO:0047497)3.89928661
34neuron-neuron synaptic transmission (GO:0007270)3.88612636
35lung secretory cell differentiation (GO:0061140)3.85352190
36glutamate receptor signaling pathway (GO:0007215)3.84887124
37establishment of mitochondrion localization (GO:0051654)3.83109180
38negative regulation of axon extension (GO:0030517)3.82906157
39regulation of synaptic transmission, glutamatergic (GO:0051966)3.81161897
40adaptation of signaling pathway (GO:0023058)3.80598795
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.80573148
42protein localization to synapse (GO:0035418)3.77291841
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.72984167
44isoprenoid biosynthetic process (GO:0008299)3.70373628
45presynaptic membrane assembly (GO:0097105)3.69610972
46synaptic transmission, glutamatergic (GO:0035249)3.69395596
47central nervous system neuron axonogenesis (GO:0021955)3.66315102
48regulation of development, heterochronic (GO:0040034)3.65952664
49axon extension involved in axon guidance (GO:0048846)3.63055197
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.63055197
51synaptic vesicle exocytosis (GO:0016079)3.61144211
52startle response (GO:0001964)3.58809849
53regulation of growth hormone secretion (GO:0060123)3.55899485
54detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.55119038
55auditory behavior (GO:0031223)3.54485858
56calcium ion import (GO:0070509)3.52545847
57regulation of synaptic vesicle exocytosis (GO:2000300)3.51741353
58presynaptic membrane organization (GO:0097090)3.51457458
59nucleobase catabolic process (GO:0046113)3.49173146
60behavioral response to ethanol (GO:0048149)3.48616980
61hindbrain development (GO:0030902)3.48382708
62striatum development (GO:0021756)3.47755377
63negative regulation of cation channel activity (GO:2001258)3.47578689
64regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45345638
65RNA destabilization (GO:0050779)3.44652509
66neuronal action potential (GO:0019228)3.43936585
67negative regulation of axon guidance (GO:1902668)3.43726534
68cAMP catabolic process (GO:0006198)3.42938954
69regulation of collateral sprouting (GO:0048670)3.41723694
70postsynaptic membrane organization (GO:0001941)3.40922680
71mesenchymal cell differentiation involved in renal system development (GO:2001012)3.36361099
72mesenchymal cell differentiation involved in kidney development (GO:0072161)3.36361099
73regulation of membrane depolarization (GO:0003254)3.34737993
74regulation of synapse structural plasticity (GO:0051823)3.30681088
75regulation of cilium movement (GO:0003352)3.30349710
76positive regulation of male gonad development (GO:2000020)3.28447253
77olfactory bulb development (GO:0021772)3.28227458
78* positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26735247
79dendritic spine morphogenesis (GO:0060997)3.26686388
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.24777990
81retinal cone cell development (GO:0046549)3.23187868
82prepulse inhibition (GO:0060134)3.22070257
83synaptic vesicle maturation (GO:0016188)3.20787994
84locomotory exploration behavior (GO:0035641)3.20587747
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19301276
86positive regulation of neurotransmitter transport (GO:0051590)3.18495265
87righting reflex (GO:0060013)3.15344770
88positive regulation of cytokinesis (GO:0032467)3.14992171
89membrane hyperpolarization (GO:0060081)3.14882041
90* regulation of synaptic transmission, GABAergic (GO:0032228)3.14876289
91positive regulation of growth hormone secretion (GO:0060124)3.14620013
92* response to auditory stimulus (GO:0010996)3.14482201
93retinoic acid metabolic process (GO:0042573)3.13952313
94regulation of synapse maturation (GO:0090128)3.12071806
95cyclic nucleotide catabolic process (GO:0009214)3.11016109
96serotonin receptor signaling pathway (GO:0007210)3.09959401
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.09380224
98microtubule nucleation (GO:0007020)3.08973943
99regulation of synaptic vesicle transport (GO:1902803)3.08400718
100adult walking behavior (GO:0007628)3.06083218
101membrane depolarization (GO:0051899)3.06007174
102synaptic vesicle endocytosis (GO:0048488)3.04495819
103positive regulation of microtubule polymerization (GO:0031116)3.03458688
104negative regulation of systemic arterial blood pressure (GO:0003085)3.02813080
105negative regulation of oligodendrocyte differentiation (GO:0048715)3.02487445
106facial nerve structural organization (GO:0021612)3.02266113
107neurotransmitter secretion (GO:0007269)3.01821689
108positive regulation of neurotransmitter secretion (GO:0001956)3.00770492
109transmission of nerve impulse (GO:0019226)2.99872479
110fibroblast migration (GO:0010761)2.99293524
111response to histamine (GO:0034776)2.98735814
112paraxial mesoderm development (GO:0048339)2.98699163
113detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.96123030
114regulation of neuronal synaptic plasticity (GO:0048168)2.96079601
115mechanosensory behavior (GO:0007638)2.95997496
116retinal rod cell development (GO:0046548)2.95724787
117gamma-aminobutyric acid transport (GO:0015812)2.94519044
118positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94382877
119positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94292956
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94201813
121positive regulation of synapse assembly (GO:0051965)2.93986529
122regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93674394
123regulation of synapse assembly (GO:0051963)2.93338074
124negative regulation of dendrite development (GO:2000171)2.92087832
125long-term synaptic potentiation (GO:0060291)2.91143027
126regulation of osteoblast proliferation (GO:0033688)2.90034324
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.89464684
128neuron recognition (GO:0008038)2.88968039
129oligodendrocyte differentiation (GO:0048709)2.87887084
130daunorubicin metabolic process (GO:0044597)2.87691883
131polyketide metabolic process (GO:0030638)2.87691883
132doxorubicin metabolic process (GO:0044598)2.87691883
133regulation of neurotransmitter uptake (GO:0051580)2.87017544
134synapse assembly (GO:0007416)2.86763024
135positive regulation of membrane potential (GO:0045838)2.86208252
136positive regulation of synapse maturation (GO:0090129)2.86117535
137glutamate secretion (GO:0014047)2.84922374
138negative regulation of adenylate cyclase activity (GO:0007194)2.83170759
139regulation of axon extension involved in axon guidance (GO:0048841)2.82181149
140regulation of postsynaptic membrane potential (GO:0060078)2.82162180
141negative regulation of smoothened signaling pathway (GO:0045879)2.82131389
142spinal cord development (GO:0021510)2.81743313
143regulation of neurotransmitter transport (GO:0051588)2.81364896
144response to amphetamine (GO:0001975)2.81008491
145negative regulation of astrocyte differentiation (GO:0048712)2.80757794
146negative regulation of axon extension involved in axon guidance (GO:0048843)2.80402035
147behavioral response to nicotine (GO:0035095)2.80086771
148negative regulation of appetite (GO:0032099)2.79104217
149negative regulation of response to food (GO:0032096)2.79104217
150regulation of neurotransmitter secretion (GO:0046928)2.78284358
151regulation of energy homeostasis (GO:2000505)2.78271279
152substrate-independent telencephalic tangential migration (GO:0021826)2.78127602
153substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.78127602
154neuronal action potential propagation (GO:0019227)2.77806113
155negative regulation of stem cell proliferation (GO:2000647)2.77740555
156ganglion development (GO:0061548)2.77543582
157* drinking behavior (GO:0042756)2.76057998
158cellular potassium ion homeostasis (GO:0030007)2.76012306
159retinal ganglion cell axon guidance (GO:0031290)2.75691103
160negative regulation of embryonic development (GO:0045992)2.75530035
161* long-term memory (GO:0007616)2.75427156
162positive regulation of dendritic spine morphogenesis (GO:0061003)2.74337530
163adult behavior (GO:0030534)2.74083625
164G-protein coupled receptor internalization (GO:0002031)2.72998022
165* learning (GO:0007612)2.72278675
166cerebral cortex radially oriented cell migration (GO:0021799)2.72211196
167behavioral response to cocaine (GO:0048148)2.70787937
168axonal fasciculation (GO:0007413)2.70368990
169glycine transport (GO:0015816)2.68683923
170innervation (GO:0060384)2.68498622
171regulation of dendritic spine morphogenesis (GO:0061001)2.66957026
172regulation of synapse organization (GO:0050807)2.64266646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.35784804
2EZH2_22144423_ChIP-Seq_EOC_Human4.24451950
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.10858995
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87014371
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74976742
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74470102
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72160181
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71530007
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52980748
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.52170167
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.51888519
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49878071
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.47186340
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41181132
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40333980
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40333980
17TAF15_26573619_Chip-Seq_HEK293_Human2.38166414
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28600194
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26605151
20ZNF274_21170338_ChIP-Seq_K562_Hela2.19447847
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19178853
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.12541294
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.07606901
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.07034004
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05037494
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04816298
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04383575
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02473019
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01800669
30DROSHA_22980978_ChIP-Seq_HELA_Human1.98999205
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95455619
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92717777
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84105138
34P300_19829295_ChIP-Seq_ESCs_Human1.82727196
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.81895720
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81615963
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79923104
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.79056979
39GATA1_22025678_ChIP-Seq_K562_Human1.73682477
40AR_21572438_ChIP-Seq_LNCaP_Human1.72055916
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65225600
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.63964417
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58750123
44RNF2_27304074_Chip-Seq_NSC_Mouse1.58444713
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56977587
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54685289
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.54069141
48* CBP_20019798_ChIP-Seq_JUKART_Human1.53133638
49* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53133638
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50424594
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.50247875
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.49622197
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.47176220
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46109770
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43174353
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38445985
57* AR_25329375_ChIP-Seq_VCAP_Human1.37280254
58BCAT_22108803_ChIP-Seq_LS180_Human1.36977260
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36943950
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36352852
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35460900
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35460900
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.35110958
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35002815
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.30987263
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30523154
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.29285815
68FUS_26573619_Chip-Seq_HEK293_Human1.29235448
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28700720
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28542672
71* STAT3_23295773_ChIP-Seq_U87_Human1.26043100
72* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25867419
73TP53_18474530_ChIP-ChIP_U2OS_Human1.24877037
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24726515
75P53_22387025_ChIP-Seq_ESCs_Mouse1.24651600
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.24234225
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24037655
78* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23483631
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23410057
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22615096
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22476271
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21316883
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.18922577
84* PRDM14_20953172_ChIP-Seq_ESCs_Human1.18372135
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18096778
86ER_23166858_ChIP-Seq_MCF-7_Human1.17869464
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17374538
88IGF1R_20145208_ChIP-Seq_DFB_Human1.16480718
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16180277
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15915827
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.14846721
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14100270
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13974382
94RXR_22108803_ChIP-Seq_LS180_Human1.13546252
95TP53_16413492_ChIP-PET_HCT116_Human1.13440690
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13050751
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.13020598
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.12945266
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12365209
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12365209
101TCF4_23295773_ChIP-Seq_U87_Human1.12260676
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12141202
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12095046
104* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11574751
105RUNX2_22187159_ChIP-Seq_PCA_Human1.10522857
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10442093
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10400900
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10225398
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08817392
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.08726543
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.07995472
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.06385420
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05656482
114VDR_22108803_ChIP-Seq_LS180_Human1.05312137
115* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04842176
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04824481
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04358208
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.04217258
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03787000
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03412887
121* TCF4_22108803_ChIP-Seq_LS180_Human1.03196012
122AHR_22903824_ChIP-Seq_MCF-7_Human1.02972897
123SMAD3_21741376_ChIP-Seq_ESCs_Human1.01975736
124AR_19668381_ChIP-Seq_PC3_Human1.01828888
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01539136
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01070877
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.00728027
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00727891
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00430768
130SOX9_26525672_Chip-Seq_HEART_Mouse0.97807038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo5.38557674
2MP0003880_abnormal_central_pattern3.92402462
3MP0004859_abnormal_synaptic_plasticity3.87518720
4MP0002822_catalepsy3.47312939
5MP0005646_abnormal_pituitary_gland3.17595797
6MP0003635_abnormal_synaptic_transmissio3.11476940
7* MP0009745_abnormal_behavioral_response3.05945327
8MP0001188_hyperpigmentation2.89391132
9MP0009046_muscle_twitch2.84255001
10MP0001486_abnormal_startle_reflex2.81104556
11MP0005645_abnormal_hypothalamus_physiol2.81102721
12MP0002063_abnormal_learning/memory/cond2.73861588
13MP0005423_abnormal_somatic_nervous2.73820188
14MP0002064_seizures2.73307919
15MP0006292_abnormal_olfactory_placode2.66205188
16MP0001984_abnormal_olfaction2.60119991
17* MP0002572_abnormal_emotion/affect_behav2.52495613
18MP0002653_abnormal_ependyma_morphology2.50471442
19* MP0001529_abnormal_vocalization2.39999913
20MP0005623_abnormal_meninges_morphology2.24174524
21MP0001501_abnormal_sleep_pattern2.19306089
22* MP0002272_abnormal_nervous_system2.14293104
23* MP0001968_abnormal_touch/_nociception2.13349676
24MP0000566_synostosis2.04747327
25MP0002557_abnormal_social/conspecific_i1.95926103
26MP0003787_abnormal_imprinting1.90524478
27MP0010386_abnormal_urinary_bladder1.88229064
28MP0000569_abnormal_digit_pigmentation1.83814172
29* MP0002067_abnormal_sensory_capabilities1.83366824
30MP0006276_abnormal_autonomic_nervous1.74135106
31MP0002102_abnormal_ear_morphology1.68931783
32MP0000778_abnormal_nervous_system1.67525248
33MP0005551_abnormal_eye_electrophysiolog1.67047245
34MP0001440_abnormal_grooming_behavior1.65347199
35* MP0002734_abnormal_mechanical_nocicepti1.63175399
36MP0003646_muscle_fatigue1.63101431
37MP0002638_abnormal_pupillary_reflex1.62534306
38MP0002184_abnormal_innervation1.59889234
39MP0002234_abnormal_pharynx_morphology1.55338012
40MP0003329_amyloid_beta_deposits1.53709422
41MP0005499_abnormal_olfactory_system1.51464493
42MP0005394_taste/olfaction_phenotype1.51464493
43* MP0002736_abnormal_nociception_after1.50481782
44MP0004858_abnormal_nervous_system1.47126127
45* MP0002277_abnormal_respiratory_mucosa1.46395948
46MP0003122_maternal_imprinting1.45571062
47* MP0002735_abnormal_chemical_nociception1.44790088
48MP0004270_analgesia1.43205487
49MP0005171_absent_coat_pigmentation1.42926301
50MP0001502_abnormal_circadian_rhythm1.42841943
51* MP0004924_abnormal_behavior1.42688764
52* MP0005386_behavior/neurological_phenoty1.42688764
53* MP0001970_abnormal_pain_threshold1.38739565
54MP0001177_atelectasis1.34938609
55MP0003136_yellow_coat_color1.30654477
56MP0008057_abnormal_DNA_replication1.29398580
57MP0008569_lethality_at_weaning1.27214011
58MP0004742_abnormal_vestibular_system1.26786305
59MP0005367_renal/urinary_system_phenotyp1.26516514
60MP0000516_abnormal_urinary_system1.26516514
61MP0005409_darkened_coat_color1.25349178
62MP0002733_abnormal_thermal_nociception1.25198309
63MP0003879_abnormal_hair_cell1.22153498
64MP0001661_extended_life_span1.20579822
65MP0000026_abnormal_inner_ear1.20481927
66MP0000955_abnormal_spinal_cord1.20007246
67MP0002090_abnormal_vision1.19632551
68MP0003632_abnormal_nervous_system1.18590334
69MP0002882_abnormal_neuron_morphology1.15305377
70MP0005670_abnormal_white_adipose1.15268437
71MP0000631_abnormal_neuroendocrine_gland1.14285519
72MP0004130_abnormal_muscle_cell1.14275906
73* MP0004811_abnormal_neuron_physiology1.12202357
74MP0004142_abnormal_muscle_tone1.10616834
75MP0002909_abnormal_adrenal_gland1.09841680
76MP0001905_abnormal_dopamine_level1.09076417
77MP0003115_abnormal_respiratory_system1.08847747
78MP0008789_abnormal_olfactory_epithelium1.06576281
79MP0002876_abnormal_thyroid_physiology1.02854294
80MP0003861_abnormal_nervous_system1.02572399
81* MP0002066_abnormal_motor_capabilities/c1.02172430
82MP0001963_abnormal_hearing_physiology0.98990795
83MP0003718_maternal_effect0.97617348
84MP0005248_abnormal_Harderian_gland0.95034302
85MP0004782_abnormal_surfactant_physiolog0.93813566
86MP0000013_abnormal_adipose_tissue0.93104759
87MP0005167_abnormal_blood-brain_barrier0.91421161
88MP0004381_abnormal_hair_follicle0.91102269
89MP0001879_abnormal_lymphatic_vessel0.90972188
90MP0001986_abnormal_taste_sensitivity0.90893977
91MP0002752_abnormal_somatic_nervous0.90628688
92MP0002163_abnormal_gland_morphology0.87941369
93MP0005253_abnormal_eye_physiology0.85448607
94MP0000534_abnormal_ureter_morphology0.84225042
95MP0004885_abnormal_endolymph0.83604785
96MP0008961_abnormal_basal_metabolism0.83387002
97MP0001664_abnormal_digestion0.83143395
98MP0002069_abnormal_eating/drinking_beha0.82591111
99MP0002896_abnormal_bone_mineralization0.82494352
100MP0008770_decreased_survivor_rate0.81712402
101MP0003755_abnormal_palate_morphology0.81416428
102MP0002152_abnormal_brain_morphology0.78727408
103MP0003121_genomic_imprinting0.76593066
104MP0003634_abnormal_glial_cell0.76193486
105* MP0003633_abnormal_nervous_system0.75153551
106MP0003119_abnormal_digestive_system0.74218324
107MP0003690_abnormal_glial_cell0.72952390
108MP0002751_abnormal_autonomic_nervous0.72725540
109MP0008874_decreased_physiological_sensi0.72475528
110* MP0001943_abnormal_respiration0.71223732
111MP0002233_abnormal_nose_morphology0.70287032
112MP0003890_abnormal_embryonic-extraembry0.69356826
113* MP0008872_abnormal_physiological_respon0.69167575
114MP0001346_abnormal_lacrimal_gland0.69140911
115MP0008004_abnormal_stomach_pH0.68792845
116MP0002938_white_spotting0.67496592
117MP0002116_abnormal_craniofacial_bone0.67067732
118MP0005448_abnormal_energy_balance0.66909377
119MP0009697_abnormal_copulation0.66846569
120MP0004133_heterotaxia0.66315193
121MP0005503_abnormal_tendon_morphology0.66238455
122MP0003183_abnormal_peptide_metabolism0.65572342
123MP0000372_irregular_coat_pigmentation0.65231928
124MP0000163_abnormal_cartilage_morphology0.64739745
125MP0003938_abnormal_ear_development0.64418648
126MP0005195_abnormal_posterior_eye0.63973742
127MP0001270_distended_abdomen0.63968555
128MP0003172_abnormal_lysosome_physiology0.63124910
129MP0003937_abnormal_limbs/digits/tail_de0.62936138
130* MP0003631_nervous_system_phenotype0.62043666
131MP0002229_neurodegeneration0.61706477
132MP0004085_abnormal_heartbeat0.61130508
133MP0005275_abnormal_skin_tensile0.60613647
134MP0001485_abnormal_pinna_reflex0.60268525
135MP0005647_abnormal_sex_gland0.60218669
136MP0000604_amyloidosis0.59690316
137MP0000015_abnormal_ear_pigmentation0.56998007

Predicted human phenotypes

RankGene SetZ-score
1Natal tooth (HP:0000695)7.34060452
2Neonatal short-limb short stature (HP:0008921)6.15409387
3Focal motor seizures (HP:0011153)5.81707831
4Hypoproteinemia (HP:0003075)4.95650020
5Thyroid-stimulating hormone excess (HP:0002925)4.60065347
6Febrile seizures (HP:0002373)4.47132977
7Epileptic encephalopathy (HP:0200134)4.33205266
8Hyperventilation (HP:0002883)4.20849455
9Asymmetry of the thorax (HP:0001555)4.15524928
10Broad ribs (HP:0000885)3.98423016
11Myokymia (HP:0002411)3.98065055
12Advanced eruption of teeth (HP:0006288)3.84524323
13Focal seizures (HP:0007359)3.65942068
14Panhypogammaglobulinemia (HP:0003139)3.63934389
15Long clavicles (HP:0000890)3.46043150
16Abnormality of the antihelix (HP:0009738)3.42479334
17Facial cleft (HP:0002006)3.33640575
18Aplasia cutis congenita (HP:0001057)3.27727375
19Abnormal hair whorl (HP:0010721)3.18608665
20Severe combined immunodeficiency (HP:0004430)3.16522850
21Protruding tongue (HP:0010808)3.16330978
22Thyroiditis (HP:0100646)3.15945698
23Fibular hypoplasia (HP:0003038)3.14965628
24Tracheomalacia (HP:0002779)3.11620383
25Short 4th metacarpal (HP:0010044)3.09544351
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09544351
27Broad-based gait (HP:0002136)3.07105893
28Aplasia involving bones of the extremities (HP:0009825)3.06867250
29Aplasia involving bones of the upper limbs (HP:0009823)3.06867250
30Aplasia of the phalanges of the hand (HP:0009802)3.06867250
31Septo-optic dysplasia (HP:0100842)3.01130327
32Generalized tonic-clonic seizures (HP:0002069)2.97231291
33Anal stenosis (HP:0002025)2.91496813
34Abnormality of the labia minora (HP:0012880)2.90987653
35Abnormality of the lumbar spine (HP:0100712)2.88667656
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.86759376
37Absent/shortened dynein arms (HP:0200106)2.86759376
38Decreased central vision (HP:0007663)2.83038191
39Absence seizures (HP:0002121)2.78580230
40Fair hair (HP:0002286)2.77502740
41Dialeptic seizures (HP:0011146)2.74039469
42Amyotrophic lateral sclerosis (HP:0007354)2.73236886
43Congenital stationary night blindness (HP:0007642)2.73031646
44Progressive cerebellar ataxia (HP:0002073)2.72395801
45Atonic seizures (HP:0010819)2.69712339
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.66362065
47B lymphocytopenia (HP:0010976)2.62467312
48Absent speech (HP:0001344)2.61885627
49Cubitus valgus (HP:0002967)2.58464689
50Abnormality of B cell number (HP:0010975)2.56813241
51Synostosis of carpal bones (HP:0005048)2.54331508
52Gait imbalance (HP:0002141)2.51422859
53Hip dysplasia (HP:0001385)2.50481890
54Complete atrioventricular canal defect (HP:0001674)2.48504008
55Neurofibrillary tangles (HP:0002185)2.47199642
56Partial agenesis of the corpus callosum (HP:0001338)2.46615256
57Nephrogenic diabetes insipidus (HP:0009806)2.45257879
58Congenital primary aphakia (HP:0007707)2.44421824
59Abnormal ciliary motility (HP:0012262)2.43743009
60Medial flaring of the eyebrow (HP:0010747)2.43545965
61Intestinal atresia (HP:0011100)2.38829063
62Fetal akinesia sequence (HP:0001989)2.37881896
63Abnormality of the pons (HP:0007361)2.37636944
64Generalized hypopigmentation of hair (HP:0011358)2.37051077
65Midline defect of the nose (HP:0004122)2.35117540
66Abnormality of the 4th metacarpal (HP:0010012)2.34087755
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31532454
68Polyphagia (HP:0002591)2.28942046
69Combined immunodeficiency (HP:0005387)2.26963667
70Limb dystonia (HP:0002451)2.24045232
71Blue irides (HP:0000635)2.20573514
72Abnormality of the right ventricle (HP:0001707)2.20342617
73Exotropia (HP:0000577)2.20096671
74Central scotoma (HP:0000603)2.20091527
75Hypoplasia of the pons (HP:0012110)2.19124604
76Visual hallucinations (HP:0002367)2.18202597
77Narrow nasal bridge (HP:0000446)2.17948301
78True hermaphroditism (HP:0010459)2.17651537
79Abnormality of incisor morphology (HP:0011063)2.17242017
80Aplasia/Hypoplasia of the fibula (HP:0006492)2.14998579
81Truncal ataxia (HP:0002078)2.14351175
82Drooling (HP:0002307)2.11881999
83Excessive salivation (HP:0003781)2.11881999
84Hypoplasia of the thymus (HP:0000778)2.10408788
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10179678
86Nuclear cataract (HP:0100018)2.10152512
87Dyschromatopsia (HP:0007641)2.09378897
88Optic nerve hypoplasia (HP:0000609)2.08605275
89Abnormality of the alveolar ridges (HP:0006477)2.05283160
90Alacrima (HP:0000522)2.04729802
91Epileptiform EEG discharges (HP:0011182)2.04455018
92Retinal dysplasia (HP:0007973)2.04341150
93Gaze-evoked nystagmus (HP:0000640)2.03918090
94Urinary bladder sphincter dysfunction (HP:0002839)2.03800581
95Abnormality of binocular vision (HP:0011514)2.03713067
96Diplopia (HP:0000651)2.03713067
97Aplasia/Hypoplasia of the uvula (HP:0010293)2.02806498
98Erythroderma (HP:0001019)2.02484478
99Anxiety (HP:0000739)2.01703158
100Abnormal eating behavior (HP:0100738)2.01034373
101Postaxial foot polydactyly (HP:0001830)2.00487807
102Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.00330486
103Dysdiadochokinesis (HP:0002075)1.99437347
104Esophageal atresia (HP:0002032)1.98999425
105Prolonged QT interval (HP:0001657)1.98596136
106Abnormality of the nasal septum (HP:0000419)1.98458974
107Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.98077502
108Abnormal respiratory epithelium morphology (HP:0012253)1.97925322
109Abnormal respiratory motile cilium morphology (HP:0005938)1.97925322
110Abnormality of the epiphyses of the hand (HP:0005924)1.97658726
111Abnormality of alanine metabolism (HP:0010916)1.97458269
112Hyperalaninemia (HP:0003348)1.97458269
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97458269
114Tented upper lip vermilion (HP:0010804)1.96093034
115Lissencephaly (HP:0001339)1.95774111
116Cerebral inclusion bodies (HP:0100314)1.95691568
117Torticollis (HP:0000473)1.94641068
118Zonular cataract (HP:0010920)1.94407767
119EEG with generalized epileptiform discharges (HP:0011198)1.94089490
120Specific learning disability (HP:0001328)1.93561814
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.92514374
122Atrioventricular canal defect (HP:0006695)1.92427989
123Abnormality of macular pigmentation (HP:0008002)1.91856854
124Abnormal EKG (HP:0003115)1.88744125
125Short ribs (HP:0000773)1.88433547
126Delayed closure of the anterior fontanelle (HP:0001476)1.88254267
127Microtia (HP:0008551)1.87448602
128Aplasia/Hypoplasia of the lens (HP:0008063)1.86943333
129Poor eye contact (HP:0000817)1.85819020
130Depression (HP:0000716)1.84876992
131Absent eyebrow (HP:0002223)1.84083128
132Cutaneous finger syndactyly (HP:0010554)1.83504398
133Mutism (HP:0002300)1.83481328
134Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.83391862
135Omphalocele (HP:0001539)1.81368585
136Genetic anticipation (HP:0003743)1.81091850
137Congenital sensorineural hearing impairment (HP:0008527)1.81041775
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.80614269
139Hypoplasia of the fovea (HP:0007750)1.80614269
140Abnormality of salivation (HP:0100755)1.79916552
141Morphological abnormality of the middle ear (HP:0008609)1.79498095
142Fibular aplasia (HP:0002990)1.79456027
143Hypothermia (HP:0002045)1.79247363
144Akinesia (HP:0002304)1.79094642
145Abnormality of the carotid arteries (HP:0005344)1.76778628
146Adactyly (HP:0009776)1.76365790
147Amblyopia (HP:0000646)1.76183592
148Overfolded helix (HP:0000396)1.76137523
149Meckel diverticulum (HP:0002245)1.74062859
150Sleep apnea (HP:0010535)1.72072168
151Astigmatism (HP:0000483)1.70268116
152White forelock (HP:0002211)1.70178306
153Abnormality of the diencephalon (HP:0010662)1.70172875
154Prostate neoplasm (HP:0100787)1.70019618
155Incomplete penetrance (HP:0003829)1.69571727
156Nasal speech (HP:0001611)1.68687297
157Pancreatic fibrosis (HP:0100732)1.67912671
158Widely spaced teeth (HP:0000687)1.67912055
159Labial hypoplasia (HP:0000066)1.67755154
160Down-sloping shoulders (HP:0200021)1.67357449
161Neoplasm of the heart (HP:0100544)1.67061576
162Hemiparesis (HP:0001269)1.66341800
163Abnormal respiratory motile cilium physiology (HP:0012261)1.66291485
164Atelectasis (HP:0100750)1.66103904
165Postaxial hand polydactyly (HP:0001162)1.65732179
166Postural instability (HP:0002172)1.65709306
167Vaginal atresia (HP:0000148)1.65000884
168Anophthalmia (HP:0000528)1.64901340
169Abnormality of the sella turcica (HP:0002679)1.64777966
170Cutaneous syndactyly (HP:0012725)1.64487846
171Failure to thrive in infancy (HP:0001531)1.64040661
172Patchy hypopigmentation of hair (HP:0011365)1.63651371
173Medulloblastoma (HP:0002885)1.63596808
174Focal dystonia (HP:0004373)1.63464764
175Poor coordination (HP:0002370)1.63380707
176Genital tract atresia (HP:0001827)1.63342011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.16249411
2CASK3.72844920
3SIK33.62691498
4NTRK33.27605062
5MAP2K72.92584968
6NTRK22.78595731
7PRPF4B2.65678207
8PNCK2.55454499
9MAP3K122.54460485
10TNIK2.42821904
11MARK12.39174194
12BRSK22.33051399
13CDK122.25457010
14NEK92.04478031
15DYRK22.03464362
16TAOK21.97035931
17MAP3K41.81258287
18MAPK131.73947218
19SIK21.70108748
20NEK61.67952578
21MINK11.65925453
22KSR11.63552653
23MARK21.60289893
24SGK21.56608561
25BCR1.44786667
26GRK71.41580014
27EPHB21.38477249
28FES1.34288827
29STK38L1.34259080
30RIPK41.33135316
31FGFR21.32236617
32BMPR21.30860822
33TNK21.29926747
34LATS11.27977513
35ADRBK21.27191203
36SGK4941.27005844
37SGK2231.27005844
38PBK1.25314508
39PLK21.24874067
40CSNK1G21.19251960
41YES11.18988693
42MAP3K131.18589919
43NUAK11.18099242
44AKT31.17153720
45CDK81.16935440
46INSRR1.16783035
47CDK31.14397207
48BMPR1B1.12776170
49MAP3K71.10788009
50STK111.10759496
51PRKCE1.10596181
52DAPK21.10165819
53STK381.06735736
54PINK11.05633012
55MAP3K141.03597292
56ABL21.03157432
57MAP2K41.00988360
58BRD40.99801810
59MKNK20.98922405
60ZAK0.98234800
61CDK50.93657033
62WNK30.87331874
63PRKCG0.86858640
64PRKAA10.86470689
65CAMK10.85825052
66MAP3K90.85437960
67VRK10.85287280
68KSR20.85101637
69TXK0.83050343
70MAP3K60.82326339
71MAPK120.79558486
72CAMK2A0.78029152
73GRK50.77638973
74CAMK40.76944081
75MAP3K20.76653681
76SGK10.75830614
77SGK30.73619402
78GSK3A0.72828541
79WEE10.71471316
80ERBB30.70411887
81DYRK30.70409786
82TIE10.69872374
83PRKD30.69485572
84DYRK1A0.69105651
85NME10.68213231
86PAK30.64655579
87CAMKK10.63799000
88MAP2K60.63166514
89PLK40.62972253
90CSNK1A1L0.62683449
91TYRO30.62624530
92MUSK0.60213828
93CSNK1D0.59047681
94DAPK10.58311964
95PAK60.57082922
96CDC42BPA0.56996716
97EIF2AK20.56391747
98RAF10.55582856
99FER0.55006574
100FRK0.53111608
101PRKCI0.50753257
102PRKCZ0.49952531
103MAPK150.49883128
104BRSK10.46956890
105CAMK2G0.46671530
106IRAK30.43597865
107HCK0.42460580
108PRKCH0.41784815
109MAPK70.41582676
110PHKG20.41456496
111PHKG10.41456496
112KDR0.39392174
113MET0.38732879
114PKN10.38542632
115CDK190.38421705
116ADRBK10.37829755
117UHMK10.37381641
118PTK2B0.36221889
119PRKAA20.36205849
120PRKCA0.35554009
121PRKACA0.35313884
122CSNK1G10.34923290
123PRKG10.34569242
124MAP3K110.34517749
125CDK150.34066248
126ROCK10.33472481
127GRK10.32767476
128CAMK2B0.32754851
129MAP3K50.32737758
130RPS6KB10.32647136
131CAMKK20.31876823
132CDK180.31833501
133WNK10.31759611
134MKNK10.31740212
135CSNK1G30.31291385
136CSNK1A10.30440152
137ERBB20.30360894
138ROCK20.30298705
139FYN0.30233289
140PRKCD0.29782458
141CAMK2D0.29468158
142RPS6KA30.28188245
143FGR0.26822820
144MAP2K10.26749422
145CAMK1G0.26392459

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.21184770
2Morphine addiction_Homo sapiens_hsa050323.24129622
3Synaptic vesicle cycle_Homo sapiens_hsa047213.10447947
4GABAergic synapse_Homo sapiens_hsa047273.03530375
5ABC transporters_Homo sapiens_hsa020103.03106137
6Olfactory transduction_Homo sapiens_hsa047402.99862671
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91447264
8Circadian entrainment_Homo sapiens_hsa047132.67464717
9Non-homologous end-joining_Homo sapiens_hsa034502.63977984
10Glutamatergic synapse_Homo sapiens_hsa047242.42891618
11Taste transduction_Homo sapiens_hsa047422.37311174
12Serotonergic synapse_Homo sapiens_hsa047262.15420853
13* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.08171484
14Collecting duct acid secretion_Homo sapiens_hsa049662.03179916
15Salivary secretion_Homo sapiens_hsa049701.94384523
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87132025
17Renin secretion_Homo sapiens_hsa049241.81327765
18Cholinergic synapse_Homo sapiens_hsa047251.81096754
19Cocaine addiction_Homo sapiens_hsa050301.78897885
20Amphetamine addiction_Homo sapiens_hsa050311.76335918
21Dopaminergic synapse_Homo sapiens_hsa047281.75655981
22* Calcium signaling pathway_Homo sapiens_hsa040201.75177993
23Insulin secretion_Homo sapiens_hsa049111.69501663
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48287053
25Axon guidance_Homo sapiens_hsa043601.43464640
26Long-term potentiation_Homo sapiens_hsa047201.40118030
27Long-term depression_Homo sapiens_hsa047301.37275616
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34869276
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34116084
30Phototransduction_Homo sapiens_hsa047441.33481434
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33433227
32Butanoate metabolism_Homo sapiens_hsa006501.28878889
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28587369
34Oxytocin signaling pathway_Homo sapiens_hsa049211.27073599
35Gastric acid secretion_Homo sapiens_hsa049711.24587041
36Rheumatoid arthritis_Homo sapiens_hsa053231.21438993
37Nitrogen metabolism_Homo sapiens_hsa009101.19616416
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.19006820
39Type I diabetes mellitus_Homo sapiens_hsa049401.18686546
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17940822
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15866798
42cAMP signaling pathway_Homo sapiens_hsa040241.12893690
43Vibrio cholerae infection_Homo sapiens_hsa051101.11452005
44Gap junction_Homo sapiens_hsa045401.02028054
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01699108
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97740537
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96721561
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93233488
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92004013
50Circadian rhythm_Homo sapiens_hsa047100.86741034
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.82474352
52ErbB signaling pathway_Homo sapiens_hsa040120.79186197
53Propanoate metabolism_Homo sapiens_hsa006400.79088623
54Melanogenesis_Homo sapiens_hsa049160.78653346
55GnRH signaling pathway_Homo sapiens_hsa049120.78587065
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77787352
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75124632
58Type II diabetes mellitus_Homo sapiens_hsa049300.74505687
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73305307
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72630452
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72170525
62Choline metabolism in cancer_Homo sapiens_hsa052310.71438563
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71378148
64Dilated cardiomyopathy_Homo sapiens_hsa054140.71211398
65Hippo signaling pathway_Homo sapiens_hsa043900.70952214
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70870602
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.69438574
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69144350
69Phagosome_Homo sapiens_hsa041450.68626386
70African trypanosomiasis_Homo sapiens_hsa051430.68124751
71Ras signaling pathway_Homo sapiens_hsa040140.67812859
72Fanconi anemia pathway_Homo sapiens_hsa034600.67030809
73Autoimmune thyroid disease_Homo sapiens_hsa053200.66925817
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66566704
75Chemical carcinogenesis_Homo sapiens_hsa052040.66206899
76MAPK signaling pathway_Homo sapiens_hsa040100.65844994
77Wnt signaling pathway_Homo sapiens_hsa043100.64618361
78Linoleic acid metabolism_Homo sapiens_hsa005910.61731320
79Graft-versus-host disease_Homo sapiens_hsa053320.61638239
80Chemokine signaling pathway_Homo sapiens_hsa040620.61432112
81Insulin resistance_Homo sapiens_hsa049310.59908163
82Ovarian steroidogenesis_Homo sapiens_hsa049130.59592371
83AMPK signaling pathway_Homo sapiens_hsa041520.58970882
84Notch signaling pathway_Homo sapiens_hsa043300.58257360
85Lysine degradation_Homo sapiens_hsa003100.57494570
86Rap1 signaling pathway_Homo sapiens_hsa040150.56424752
87Inositol phosphate metabolism_Homo sapiens_hsa005620.56038611
88beta-Alanine metabolism_Homo sapiens_hsa004100.55909998
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55696053
90RNA polymerase_Homo sapiens_hsa030200.55342687
91Primary immunodeficiency_Homo sapiens_hsa053400.55079785
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.54920196
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53918695
94Hedgehog signaling pathway_Homo sapiens_hsa043400.53696978
95Glutathione metabolism_Homo sapiens_hsa004800.52838742
96Cardiac muscle contraction_Homo sapiens_hsa042600.52629311
97Pancreatic secretion_Homo sapiens_hsa049720.50160794
98Glycerolipid metabolism_Homo sapiens_hsa005610.49667890
99Melanoma_Homo sapiens_hsa052180.49503574
100Alcoholism_Homo sapiens_hsa050340.47912125
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47729034
102Estrogen signaling pathway_Homo sapiens_hsa049150.47507043
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.46438895
104Dorso-ventral axis formation_Homo sapiens_hsa043200.46410548
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46374962
106Glioma_Homo sapiens_hsa052140.45527189
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.45181234
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44277372
109Tight junction_Homo sapiens_hsa045300.44040772
110FoxO signaling pathway_Homo sapiens_hsa040680.43461750
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42794422
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42033699
113Adherens junction_Homo sapiens_hsa045200.41857001
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40460514
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39706263
116Mineral absorption_Homo sapiens_hsa049780.39654493
117mTOR signaling pathway_Homo sapiens_hsa041500.39552819
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39211783
119Prion diseases_Homo sapiens_hsa050200.38818915
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38701162
121Retinol metabolism_Homo sapiens_hsa008300.38400075
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35758147
123Allograft rejection_Homo sapiens_hsa053300.34877738
124Sphingolipid metabolism_Homo sapiens_hsa006000.33157570
125Homologous recombination_Homo sapiens_hsa034400.33122308
126Prostate cancer_Homo sapiens_hsa052150.32097048
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31992338
128Basal cell carcinoma_Homo sapiens_hsa052170.31192137
129Endometrial cancer_Homo sapiens_hsa052130.30250826
130Tuberculosis_Homo sapiens_hsa051520.29350676
131Protein digestion and absorption_Homo sapiens_hsa049740.29179440
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29019067
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28591961
134Regulation of autophagy_Homo sapiens_hsa041400.28360235
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27327200
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26416945
137Thyroid hormone synthesis_Homo sapiens_hsa049180.26208239
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24327887
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.24185327
140Vitamin B6 metabolism_Homo sapiens_hsa007500.21946004
141TNF signaling pathway_Homo sapiens_hsa046680.21586313

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