TACR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.27816194
2daunorubicin metabolic process (GO:0044597)9.27816194
3polyketide metabolic process (GO:0030638)9.27816194
4estrogen biosynthetic process (GO:0006703)8.11560666
5C21-steroid hormone biosynthetic process (GO:0006700)7.29505747
6auditory receptor cell stereocilium organization (GO:0060088)7.20734262
7glucocorticoid biosynthetic process (GO:0006704)6.60001566
8negative regulation of macroautophagy (GO:0016242)6.25122359
9aminoglycoside antibiotic metabolic process (GO:0030647)5.90972568
10axon ensheathment in central nervous system (GO:0032291)5.58977690
11central nervous system myelination (GO:0022010)5.58977690
12glucocorticoid metabolic process (GO:0008211)5.58171841
13androgen biosynthetic process (GO:0006702)5.57172488
14protein-chromophore linkage (GO:0018298)4.90664228
15myelin maintenance (GO:0043217)4.81266919
16inner ear receptor stereocilium organization (GO:0060122)4.73744600
17signal peptide processing (GO:0006465)4.64024369
18C21-steroid hormone metabolic process (GO:0008207)4.59032890
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.46865960
20response to pheromone (GO:0019236)4.37255473
21cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.32430228
22tryptophan catabolic process (GO:0006569)4.24026359
23indole-containing compound catabolic process (GO:0042436)4.24026359
24indolalkylamine catabolic process (GO:0046218)4.24026359
25detection of molecule of bacterial origin (GO:0032490)4.23556304
26indolalkylamine metabolic process (GO:0006586)4.18784247
27* tachykinin receptor signaling pathway (GO:0007217)4.12956855
28neuron remodeling (GO:0016322)4.08783242
29hormone biosynthetic process (GO:0042446)4.01244500
30regulation of pigment cell differentiation (GO:0050932)3.90598023
31neuron cell-cell adhesion (GO:0007158)3.89446481
32positive regulation of developmental pigmentation (GO:0048087)3.84046662
33presynaptic membrane assembly (GO:0097105)3.76902507
34response to follicle-stimulating hormone (GO:0032354)3.75278898
35photoreceptor cell maintenance (GO:0045494)3.74477874
36estrogen metabolic process (GO:0008210)3.74423074
37tryptophan metabolic process (GO:0006568)3.73914056
38reflex (GO:0060004)3.70807975
39sphingoid metabolic process (GO:0046519)3.69006639
40androgen metabolic process (GO:0008209)3.62686090
41presynaptic membrane organization (GO:0097090)3.59301453
42relaxation of smooth muscle (GO:0044557)3.57989826
43myelination (GO:0042552)3.55574398
44ensheathment of neurons (GO:0007272)3.55160537
45axon ensheathment (GO:0008366)3.55160537
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.53114157
47ketone biosynthetic process (GO:0042181)3.52710264
48righting reflex (GO:0060013)3.49374105
49long-chain fatty acid biosynthetic process (GO:0042759)3.47524243
50renal system process involved in regulation of blood volume (GO:0001977)3.46972488
51protein K11-linked deubiquitination (GO:0035871)3.40078773
52kynurenine metabolic process (GO:0070189)3.34503783
53sulfate transmembrane transport (GO:1902358)3.32642329
54xenobiotic catabolic process (GO:0042178)3.32494153
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31211059
56regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.30510307
57DNA methylation involved in gamete generation (GO:0043046)3.28863432
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27574073
59detection of light stimulus involved in visual perception (GO:0050908)3.26065422
60detection of light stimulus involved in sensory perception (GO:0050962)3.26065422
61fatty acid elongation (GO:0030497)3.25112170
62positive regulation of actin filament depolymerization (GO:0030836)3.24054752
63neurofilament cytoskeleton organization (GO:0060052)3.23506024
64response to nitrosative stress (GO:0051409)3.23164624
65transmission of nerve impulse (GO:0019226)3.22992048
66cellular response to cadmium ion (GO:0071276)3.22522737
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22101025
68negative regulation of mast cell activation (GO:0033004)3.19221848
69cellular response to epinephrine stimulus (GO:0071872)3.18468852
70cellular response to growth hormone stimulus (GO:0071378)3.17961511
71activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.17436962
72multicellular organism reproduction (GO:0032504)3.16955141
73behavioral response to ethanol (GO:0048149)3.16717087
74membrane depolarization during action potential (GO:0086010)3.16314492
75heparin biosynthetic process (GO:0030210)3.16037673
76heparin metabolic process (GO:0030202)3.16037673
77regulation of protein glycosylation (GO:0060049)3.15725852
78regulation of activation of Janus kinase activity (GO:0010533)3.15715749
79neural tube formation (GO:0001841)3.12213658
80regulation of respiratory system process (GO:0044065)3.06264906
81cilium or flagellum-dependent cell motility (GO:0001539)3.05652434
82rhodopsin mediated signaling pathway (GO:0016056)3.05102245
83benzene-containing compound metabolic process (GO:0042537)3.04553545
84ketone body metabolic process (GO:1902224)3.00766383
85establishment of protein localization to Golgi (GO:0072600)3.00445437
86cellular response to sterol (GO:0036315)2.99107643
87NAD biosynthetic process (GO:0009435)2.98422412
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97689277
89cellular ketone body metabolic process (GO:0046950)2.96674424
90vocalization behavior (GO:0071625)2.94390075
91positive regulation of cell cycle checkpoint (GO:1901978)2.92086565
92galactose catabolic process (GO:0019388)2.91849707
93peptidyl-cysteine modification (GO:0018198)2.91714468
94progesterone metabolic process (GO:0042448)2.88736641
95amine catabolic process (GO:0009310)2.86832743
96cellular biogenic amine catabolic process (GO:0042402)2.86832743
97UDP-N-acetylglucosamine metabolic process (GO:0006047)2.86548429
98cyclic nucleotide catabolic process (GO:0009214)2.84317629
99glycosphingolipid biosynthetic process (GO:0006688)2.84001348
100indole-containing compound metabolic process (GO:0042430)2.82922563
101positive regulation of meiosis (GO:0045836)2.82852034
102piRNA metabolic process (GO:0034587)2.82533476
103aromatic amino acid family catabolic process (GO:0009074)2.82121427
104regulation of hippo signaling (GO:0035330)2.81310998
105negative regulation of response to nutrient levels (GO:0032108)2.80284831
106negative regulation of response to extracellular stimulus (GO:0032105)2.80284831
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79088577
108detection of mechanical stimulus involved in sensory perception (GO:0050974)2.78636118
109negative regulation of neurotransmitter transport (GO:0051589)2.78229779
110regulation of meiosis I (GO:0060631)2.77749463
111aromatic amino acid family metabolic process (GO:0009072)2.77414801
112dopamine transport (GO:0015872)2.76204043
113sulfate transport (GO:0008272)2.75877177
114natural killer cell activation involved in immune response (GO:0002323)2.75090217
115calcium ion import (GO:0070509)2.74752824
116monoubiquitinated protein deubiquitination (GO:0035520)2.74601168
117nonmotile primary cilium assembly (GO:0035058)2.74157045
118detection of external biotic stimulus (GO:0098581)2.73737947
119cochlea development (GO:0090102)2.69143975
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.68963986
121regulation of establishment of cell polarity (GO:2000114)2.68919427
122positive regulation of response to oxidative stress (GO:1902884)2.67375462
123positive regulation of cellular response to oxidative stress (GO:1900409)2.67375462
124sphingosine metabolic process (GO:0006670)2.67247721
125phospholipid homeostasis (GO:0055091)2.66342637
126regulation of collateral sprouting (GO:0048670)2.65979823
127urinary tract smooth muscle contraction (GO:0014848)2.65840535
128ganglion development (GO:0061548)2.65036904
129retinal cone cell development (GO:0046549)2.64673383
130behavioral response to nicotine (GO:0035095)2.63918597
131cholesterol biosynthetic process (GO:0006695)2.63417761
132regulation of sarcomere organization (GO:0060297)2.62589599
133regulation of somitogenesis (GO:0014807)2.62278958
134meiotic chromosome segregation (GO:0045132)2.60472051
135negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.60245933
136dendritic spine organization (GO:0097061)2.60038429
137* smooth muscle contraction (GO:0006939)2.60006287
138regulation of respiratory gaseous exchange (GO:0043576)2.59988939
139protein K63-linked deubiquitination (GO:0070536)2.57863331
140central nervous system projection neuron axonogenesis (GO:0021952)2.57716056
141negative regulation of complement activation (GO:0045916)2.57596572
142tonic smooth muscle contraction (GO:0014820)2.57510325
143renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.57413787
144negative regulation of systemic arterial blood pressure (GO:0003085)2.55823112
145regulation of skeletal muscle contraction (GO:0014819)2.55407313
146opioid receptor signaling pathway (GO:0038003)2.55305767
147postsynaptic membrane organization (GO:0001941)2.54290089
148protein prenylation (GO:0018342)2.54238128
149prenylation (GO:0097354)2.54238128
150hepatocyte apoptotic process (GO:0097284)2.53940601
151cellular response to gonadotropin stimulus (GO:0071371)2.53416592
152positive regulation of cell fate commitment (GO:0010455)2.52835534
153regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50705202
154negative regulation of autophagy (GO:0010507)2.50607069
155long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.50026961
156isoprenoid biosynthetic process (GO:0008299)2.49591097
157positive regulation of meiotic cell cycle (GO:0051446)2.49556890
158central nervous system neuron axonogenesis (GO:0021955)2.49207437
159regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49027711
160phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.48530256
161cerebral cortex radially oriented cell migration (GO:0021799)2.48377396
162regulation of mitotic spindle checkpoint (GO:1903504)2.48139429
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48139429
164mating behavior (GO:0007617)2.47316080
165import into cell (GO:0098657)2.47214461
166adenosine metabolic process (GO:0046085)2.45502229
167regulation of cilium movement (GO:0003352)2.45399081
168long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.45108943
169protein K48-linked deubiquitination (GO:0071108)2.44472543
170head development (GO:0060322)2.44396743
171regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.42860069
172cilium organization (GO:0044782)2.42611286
173L-fucose metabolic process (GO:0042354)2.42137395
174L-fucose catabolic process (GO:0042355)2.42137395
175fucose catabolic process (GO:0019317)2.42137395
176response to epinephrine (GO:0071871)2.42040124
177photoreceptor cell development (GO:0042461)2.41665478
178cilium morphogenesis (GO:0060271)2.41549868
179thyroid hormone metabolic process (GO:0042403)2.41530203
180regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41517861
181diol metabolic process (GO:0034311)2.41126828
182neuronal action potential (GO:0019228)2.41008257
183regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.40755351
184positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.40337547
185retinal rod cell development (GO:0046548)2.39668669
186regulation of establishment or maintenance of cell polarity (GO:0032878)2.39363516
187N-glycan processing (GO:0006491)2.38987000
188negative regulation of cAMP-mediated signaling (GO:0043951)2.38475663
189epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37980277
190cilium assembly (GO:0042384)2.37017948
191mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.36806328
192positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.36806328
193positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.36308441
194visual perception (GO:0007601)2.36060041
195regulation of neurotransmitter uptake (GO:0051580)2.35682318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.34867262
2EZH2_22144423_ChIP-Seq_EOC_Human2.93401578
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73514522
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61153423
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61153423
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56793563
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50396509
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48360318
9ZNF274_21170338_ChIP-Seq_K562_Hela2.43717625
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41499584
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.41005763
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37891472
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37378809
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35795687
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29258525
16TAF15_26573619_Chip-Seq_HEK293_Human2.28987393
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21279975
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.14913344
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.14884923
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10385957
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10153927
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08453568
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05759224
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98807879
25* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97247766
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.93614302
27ER_23166858_ChIP-Seq_MCF-7_Human1.91227969
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85570116
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85177760
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.83073596
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81950298
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.80529136
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78524716
34CBP_20019798_ChIP-Seq_JUKART_Human1.74346492
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74346492
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73140353
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.71665392
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64834470
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64535036
40P300_19829295_ChIP-Seq_ESCs_Human1.64341309
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62771265
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61832568
43VDR_22108803_ChIP-Seq_LS180_Human1.61683135
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60353565
45* EZH2_27294783_Chip-Seq_NPCs_Mouse1.59743325
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53146549
47RNF2_27304074_Chip-Seq_NSC_Mouse1.51059950
48TP53_16413492_ChIP-PET_HCT116_Human1.50422617
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49804883
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47160204
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.44539929
52TCF4_22108803_ChIP-Seq_LS180_Human1.43937095
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.43183496
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42843843
55IGF1R_20145208_ChIP-Seq_DFB_Human1.42520459
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.42243743
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42239179
58FUS_26573619_Chip-Seq_HEK293_Human1.41542394
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.39372340
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39240938
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39101929
62* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38519970
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37941556
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37660228
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36556751
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35397120
67* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34170551
68CDX2_22108803_ChIP-Seq_LS180_Human1.34086743
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.32767085
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32670538
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32199877
72NANOG_19829295_ChIP-Seq_ESCs_Human1.31995300
73SOX2_19829295_ChIP-Seq_ESCs_Human1.31995300
74KDM2B_26808549_Chip-Seq_REH_Human1.31693470
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.30595139
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.30586759
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30331724
78* FLI1_21867929_ChIP-Seq_TH2_Mouse1.30214220
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29895026
80DROSHA_22980978_ChIP-Seq_HELA_Human1.28898855
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28633204
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28462145
83* CRX_20693478_ChIP-Seq_RETINA_Mouse1.27854711
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27480511
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27221195
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27007991
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26933772
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24493506
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24493506
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.24058563
91TP53_18474530_ChIP-ChIP_U2OS_Human1.23756840
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.23405414
93AHR_22903824_ChIP-Seq_MCF-7_Human1.22917912
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.22299685
95REST_21632747_ChIP-Seq_MESCs_Mouse1.22253304
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20883327
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20883327
98SMAD4_21799915_ChIP-Seq_A2780_Human1.20654169
99P53_22387025_ChIP-Seq_ESCs_Mouse1.20134725
100* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18896180
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.18670817
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18513578
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18183852
104* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17144158
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16917389
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16801174
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16206499
108TP53_22573176_ChIP-Seq_HFKS_Human1.15838118
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15516381
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15300762
111TCF4_23295773_ChIP-Seq_U87_Human1.14192146
112RXR_22108803_ChIP-Seq_LS180_Human1.13692855
113P300_18555785_Chip-Seq_ESCs_Mouse1.13027913
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12959436
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.12738687
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12279776
117CJUN_26792858_Chip-Seq_BT549_Human1.11384330
118* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10916750
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10472572
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.10274285
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.10176249
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.10152329
123EWS_26573619_Chip-Seq_HEK293_Human1.09817673
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.09814522
125BCAT_22108803_ChIP-Seq_LS180_Human1.08772846
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08428028
127AR_25329375_ChIP-Seq_VCAP_Human1.08335416
128* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07960179
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07177692
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.07047263
131STAT3_23295773_ChIP-Seq_U87_Human1.06400832
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05844038
133RUNX2_22187159_ChIP-Seq_PCA_Human1.04823141
134EP300_21415370_ChIP-Seq_HL-1_Mouse1.04703104
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04049725
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03945688
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03808834
138GATA1_22025678_ChIP-Seq_K562_Human1.03699109
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03234531
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03155973
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01952406
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01739481
143AR_21572438_ChIP-Seq_LNCaP_Human1.00015987
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.98701963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.99270858
2MP0000372_irregular_coat_pigmentation4.90454190
3MP0000569_abnormal_digit_pigmentation3.53015309
4MP0001529_abnormal_vocalization3.41710646
5MP0008057_abnormal_DNA_replication3.18248994
6MP0001485_abnormal_pinna_reflex3.10026203
7MP0005377_hearing/vestibular/ear_phenot3.05088534
8MP0003878_abnormal_ear_physiology3.05088534
9MP0003950_abnormal_plasma_membrane3.02306882
10MP0001986_abnormal_taste_sensitivity2.81838801
11MP0008004_abnormal_stomach_pH2.80556598
12MP0004381_abnormal_hair_follicle2.79612321
13MP0003646_muscle_fatigue2.77873564
14MP0004270_analgesia2.72180768
15MP0005171_absent_coat_pigmentation2.71444534
16MP0005075_abnormal_melanosome_morpholog2.48017989
17MP0000920_abnormal_myelination2.47339409
18MP0010386_abnormal_urinary_bladder2.41014001
19MP0003880_abnormal_central_pattern2.37947501
20MP0003195_calcinosis2.36554089
21MP0001486_abnormal_startle_reflex2.32153589
22MP0005551_abnormal_eye_electrophysiolog2.18187416
23MP0004885_abnormal_endolymph2.16252797
24MP0000566_synostosis2.01355026
25MP0000778_abnormal_nervous_system1.98825245
26MP0005645_abnormal_hypothalamus_physiol1.98452076
27MP0002272_abnormal_nervous_system1.96203758
28MP0004742_abnormal_vestibular_system1.95424007
29MP0000639_abnormal_adrenal_gland1.94255124
30MP0003890_abnormal_embryonic-extraembry1.94030712
31MP0005423_abnormal_somatic_nervous1.92042215
32MP0002102_abnormal_ear_morphology1.85562383
33MP0005670_abnormal_white_adipose1.84564326
34MP0002572_abnormal_emotion/affect_behav1.84366586
35MP0009745_abnormal_behavioral_response1.83778349
36MP0000427_abnormal_hair_cycle1.83745913
37MP0005174_abnormal_tail_pigmentation1.79152110
38MP0001501_abnormal_sleep_pattern1.77453680
39MP0006292_abnormal_olfactory_placode1.73808376
40MP0003045_fibrosis1.70160885
41MP0008872_abnormal_physiological_respon1.66912819
42MP0009780_abnormal_chondrocyte_physiolo1.66233037
43MP0000631_abnormal_neuroendocrine_gland1.63743811
44MP0002822_catalepsy1.60233683
45MP0004043_abnormal_pH_regulation1.59159421
46MP0003879_abnormal_hair_cell1.58678646
47MP0005253_abnormal_eye_physiology1.57176173
48MP0000015_abnormal_ear_pigmentation1.56681142
49MP0002138_abnormal_hepatobiliary_system1.56669526
50MP0002557_abnormal_social/conspecific_i1.56196512
51MP0001188_hyperpigmentation1.53723882
52MP0001963_abnormal_hearing_physiology1.53650634
53MP0004858_abnormal_nervous_system1.51680493
54MP0002734_abnormal_mechanical_nocicepti1.50671202
55MP0001905_abnormal_dopamine_level1.49665927
56MP0005408_hypopigmentation1.46245949
57MP0003635_abnormal_synaptic_transmissio1.46051689
58MP0000026_abnormal_inner_ear1.39896396
59MP0002638_abnormal_pupillary_reflex1.39747747
60MP0004147_increased_porphyrin_level1.39240790
61MP0004215_abnormal_myocardial_fiber1.36632822
62MP0001440_abnormal_grooming_behavior1.35854682
63MP0001764_abnormal_homeostasis1.35549794
64MP0003690_abnormal_glial_cell1.32673019
65MP0005647_abnormal_sex_gland1.32259461
66MP0004036_abnormal_muscle_relaxation1.29723460
67MP0002184_abnormal_innervation1.28771279
68MP0002095_abnormal_skin_pigmentation1.28404457
69MP0001664_abnormal_digestion1.25904793
70MP0002063_abnormal_learning/memory/cond1.24555983
71MP0000579_abnormal_nail_morphology1.24187288
72MP0006054_spinal_hemorrhage1.22984357
73MP0002064_seizures1.22912325
74MP0002735_abnormal_chemical_nociception1.20682822
75MP0002233_abnormal_nose_morphology1.20353780
76MP0004924_abnormal_behavior1.19652240
77MP0005386_behavior/neurological_phenoty1.19652240
78MP0001293_anophthalmia1.19216583
79MP0002736_abnormal_nociception_after1.18012374
80MP0005410_abnormal_fertilization1.17563837
81MP0003632_abnormal_nervous_system1.17306374
82MP0000049_abnormal_middle_ear1.16742588
83MP0003941_abnormal_skin_development1.14692695
84MP0001984_abnormal_olfaction1.14421154
85MP0009046_muscle_twitch1.13546859
86MP0003136_yellow_coat_color1.12474146
87MP0000955_abnormal_spinal_cord1.09962429
88MP0008789_abnormal_olfactory_epithelium1.09491291
89MP0001968_abnormal_touch/_nociception1.09208438
90MP0004484_altered_response_of1.08529670
91MP0002254_reproductive_system_inflammat1.07918734
92MP0002090_abnormal_vision1.07581930
93MP0001346_abnormal_lacrimal_gland1.07303145
94MP0002168_other_aberrant_phenotype1.05308794
95MP0002067_abnormal_sensory_capabilities1.03758204
96MP0002938_white_spotting1.02840949
97MP0005620_abnormal_muscle_contractility1.02511722
98MP0005266_abnormal_metabolism1.01889951
99MP0000371_diluted_coat_color1.00263492
100MP0004859_abnormal_synaptic_plasticity1.00195826
101MP0008877_abnormal_DNA_methylation0.99765293
102MP0000383_abnormal_hair_follicle0.99470086
103MP0003634_abnormal_glial_cell0.99408087
104MP0005085_abnormal_gallbladder_physiolo0.99351510
105MP0006276_abnormal_autonomic_nervous0.98337203
106MP0000230_abnormal_systemic_arterial0.97949333
107MP0001324_abnormal_eye_pigmentation0.96198890
108MP0000613_abnormal_salivary_gland0.96178546
109MP0004084_abnormal_cardiac_muscle0.95326790
110MP0001348_abnormal_lacrimal_gland0.94722077
111MP0005646_abnormal_pituitary_gland0.94250124
112MP0000749_muscle_degeneration0.93908102
113MP0000013_abnormal_adipose_tissue0.91642554
114MP0001177_atelectasis0.90587991
115MP0004145_abnormal_muscle_electrophysio0.90050644
116MP0004085_abnormal_heartbeat0.89969598
117MP0006138_congestive_heart_failure0.89582746
118MP0002752_abnormal_somatic_nervous0.89508710
119MP0010329_abnormal_lipoprotein_level0.89488531
120MP0002751_abnormal_autonomic_nervous0.88986499
121MP0004134_abnormal_chest_morphology0.88885993
122MP0000762_abnormal_tongue_morphology0.88669378
123MP0002066_abnormal_motor_capabilities/c0.88307000
124MP0004130_abnormal_muscle_cell0.88153189
125MP0003633_abnormal_nervous_system0.86738702
126MP0001299_abnormal_eye_distance/0.86546581
127MP0005451_abnormal_body_composition0.85192938
128MP0001756_abnormal_urination0.84632515
129MP0010368_abnormal_lymphatic_system0.84082044
130MP0005187_abnormal_penis_morphology0.82480789
131MP0004185_abnormal_adipocyte_glucose0.81918188
132MP0008775_abnormal_heart_ventricle0.81195579
133MP0008874_decreased_physiological_sensi0.81175429
134MP0002882_abnormal_neuron_morphology0.80390260
135MP0005379_endocrine/exocrine_gland_phen0.79801621
136MP0005167_abnormal_blood-brain_barrier0.79142093
137MP0005376_homeostasis/metabolism_phenot0.78627837
138MP0001765_abnormal_ion_homeostasis0.78607216
139MP0003938_abnormal_ear_development0.78429046
140MP0000538_abnormal_urinary_bladder0.78377562
141MP0003252_abnormal_bile_duct0.78136694
142MP0003937_abnormal_limbs/digits/tail_de0.77744780
143MP0003631_nervous_system_phenotype0.77138035
144MP0008995_early_reproductive_senescence0.77136631
145MP0002876_abnormal_thyroid_physiology0.76789761
146MP0004142_abnormal_muscle_tone0.76532755
147MP0005394_taste/olfaction_phenotype0.76485689
148MP0005499_abnormal_olfactory_system0.76485689
149MP0001661_extended_life_span0.76173500
150MP0001970_abnormal_pain_threshold0.73955953
151MP0003698_abnormal_male_reproductive0.73922748
152MP0000678_abnormal_parathyroid_gland0.70800646
153MP0005310_abnormal_salivary_gland0.70790239
154MP0002229_neurodegeneration0.70144405
155MP0002332_abnormal_exercise_endurance0.69785156
156MP0002837_dystrophic_cardiac_calcinosis0.68760120
157MP0009697_abnormal_copulation0.68391356
158MP0005395_other_phenotype0.68044646
159MP0001879_abnormal_lymphatic_vessel0.68003981
160MP0001929_abnormal_gametogenesis0.65340193

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.92477109
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.92477109
3Abnormality of the corticospinal tract (HP:0002492)4.98285587
4Parakeratosis (HP:0001036)4.90505289
5Follicular hyperkeratosis (HP:0007502)4.83245775
6Gaze-evoked nystagmus (HP:0000640)4.41858019
7Upper limb muscle weakness (HP:0003484)4.37733119
8Pancreatic cysts (HP:0001737)4.35917740
9Abnormality of renin-angiotensin system (HP:0000847)4.05872594
10Hyperventilation (HP:0002883)3.86804121
11Neurofibrillary tangles (HP:0002185)3.84739459
12Abnormality of dental color (HP:0011073)3.81131956
13Decreased circulating renin level (HP:0003351)3.79664100
14Pancreatic fibrosis (HP:0100732)3.77566387
15White forelock (HP:0002211)3.57394353
16True hermaphroditism (HP:0010459)3.53726560
17Sleep apnea (HP:0010535)3.50362954
18Congenital stationary night blindness (HP:0007642)3.50199861
19Chronic hepatic failure (HP:0100626)3.45690106
20Renal salt wasting (HP:0000127)3.44006240
21Increased circulating renin level (HP:0000848)3.39571252
22Hyperaldosteronism (HP:0000859)3.26502649
23Retrobulbar optic neuritis (HP:0100654)3.21318642
24Optic neuritis (HP:0100653)3.21318642
25Osteomalacia (HP:0002749)3.18512888
26Metabolic alkalosis (HP:0200114)3.16756409
27Attenuation of retinal blood vessels (HP:0007843)3.16390961
28Cerebral hypomyelination (HP:0006808)3.15777479
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.12409809
30Absent/shortened dynein arms (HP:0200106)3.12409809
31Patchy hypopigmentation of hair (HP:0011365)3.10203854
32Intestinal atresia (HP:0011100)3.04442798
33Cerebral inclusion bodies (HP:0100314)3.02255827
34Orchitis (HP:0100796)3.01758875
35Unilateral renal agenesis (HP:0000122)2.99270097
36Recurrent corneal erosions (HP:0000495)2.92255773
37Progressive inability to walk (HP:0002505)2.85372824
38Congenital sensorineural hearing impairment (HP:0008527)2.84649580
39Medial flaring of the eyebrow (HP:0010747)2.78075545
40Abnormality of midbrain morphology (HP:0002418)2.75157530
41Molar tooth sign on MRI (HP:0002419)2.75157530
42Onion bulb formation (HP:0003383)2.74992617
43Cystic liver disease (HP:0006706)2.73808626
44Alopecia of scalp (HP:0002293)2.71256913
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.66806596
46Absent speech (HP:0001344)2.60688859
47Prolonged neonatal jaundice (HP:0006579)2.60374479
48Central scotoma (HP:0000603)2.53454091
49Blue irides (HP:0000635)2.52447708
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.51033167
51Amelogenesis imperfecta (HP:0000705)2.47819310
52Hypoplasia of the fovea (HP:0007750)2.47787011
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.47787011
54Nephronophthisis (HP:0000090)2.47208412
55Anomalous pulmonary venous return (HP:0010772)2.46855037
56Abnormal hair whorl (HP:0010721)2.43680929
57Aplasia/Hypoplasia of the macula (HP:0008059)2.43435598
58Gait imbalance (HP:0002141)2.40802089
59Abnormality of the renal medulla (HP:0100957)2.38223920
60Facial diplegia (HP:0001349)2.36829422
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.36334771
62Bony spicule pigmentary retinopathy (HP:0007737)2.36258718
63Focal seizures (HP:0007359)2.35664049
64Bilateral sensorineural hearing impairment (HP:0008619)2.34910445
65Clumsiness (HP:0002312)2.34874279
66Genetic anticipation (HP:0003743)2.34766311
67Dialeptic seizures (HP:0011146)2.33420254
68Fair hair (HP:0002286)2.33156638
69Abnormality of macular pigmentation (HP:0008002)2.32222664
70Congenital primary aphakia (HP:0007707)2.32033746
71Abolished electroretinogram (ERG) (HP:0000550)2.30893905
72Constricted visual fields (HP:0001133)2.30415195
73Absent eyelashes (HP:0000561)2.28733873
74Nephrogenic diabetes insipidus (HP:0009806)2.28676092
75Severe visual impairment (HP:0001141)2.27695048
76Renal cortical cysts (HP:0000803)2.27249824
77Conical tooth (HP:0000698)2.26765784
78Bell-shaped thorax (HP:0001591)2.25914939
79Horizontal nystagmus (HP:0000666)2.25753288
80Septo-optic dysplasia (HP:0100842)2.25334238
81Segmental peripheral demyelination/remyelination (HP:0003481)2.23092901
82Progressive cerebellar ataxia (HP:0002073)2.21850861
83Febrile seizures (HP:0002373)2.19915878
84Hypothermia (HP:0002045)2.18141954
85Adrenal hypoplasia (HP:0000835)2.17975467
86Short foot (HP:0001773)2.17161336
87Abnormal auditory evoked potentials (HP:0006958)2.16922619
88Peripheral hypomyelination (HP:0007182)2.15488956
89Aplasia/Hypoplasia affecting the retina (HP:0008061)2.15084312
90Breech presentation (HP:0001623)2.14310342
91Congenital hepatic fibrosis (HP:0002612)2.14307894
92Turricephaly (HP:0000262)2.14091848
93Thyroiditis (HP:0100646)2.13720481
94Inability to walk (HP:0002540)2.13299544
95Abnormality of the pulmonary veins (HP:0011718)2.13127781
96Focal motor seizures (HP:0011153)2.13114328
97Abnormal rod and cone electroretinograms (HP:0008323)2.12866128
98Furrowed tongue (HP:0000221)2.09443236
99Bifid scrotum (HP:0000048)2.05877709
100Clitoromegaly (HP:0000057)2.05828479
101Absent eyebrow (HP:0002223)2.05604691
102Small hand (HP:0200055)2.05545569
103Myositis (HP:0100614)2.05510112
104Nonprogressive disorder (HP:0003680)2.03031269
105Hemiparesis (HP:0001269)2.03023383
106Volvulus (HP:0002580)2.00995823
107Absent septum pellucidum (HP:0001331)1.99535395
108Protruding tongue (HP:0010808)1.98104320
109Hematochezia (HP:0002573)1.97559797
110Genital tract atresia (HP:0001827)1.96646110
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.96411585
112Acanthocytosis (HP:0001927)1.95262823
113Polydipsia (HP:0001959)1.93062153
114Abnormal drinking behavior (HP:0030082)1.93062153
115Albinism (HP:0001022)1.90533378
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90483270
117Postaxial foot polydactyly (HP:0001830)1.90203665
118Broad-based gait (HP:0002136)1.90082068
119Astigmatism (HP:0000483)1.89758106
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89600047
121Abnormal protein N-linked glycosylation (HP:0012347)1.89600047
122Abnormal protein glycosylation (HP:0012346)1.89600047
123Abnormal glycosylation (HP:0012345)1.89600047
124Synostosis of carpal bones (HP:0005048)1.88582488
125Generalized hypopigmentation of hair (HP:0011358)1.88488886
126Abnormality of potassium homeostasis (HP:0011042)1.88455629
127Abnormal ciliary motility (HP:0012262)1.87020313
128Retinitis pigmentosa (HP:0000510)1.86581585
129Prostate neoplasm (HP:0100787)1.86399137
130Scotoma (HP:0000575)1.85292641
131Ketoacidosis (HP:0001993)1.85101745
132Morphological abnormality of the inner ear (HP:0011390)1.84570918
133Vertigo (HP:0002321)1.84515461
134Accelerated skeletal maturation (HP:0005616)1.84141033
135Vaginal atresia (HP:0000148)1.83700747
136Tinnitus (HP:0000360)1.83307325
137Tented upper lip vermilion (HP:0010804)1.82578243
138Keratoconjunctivitis sicca (HP:0001097)1.81724183
139Distal lower limb amyotrophy (HP:0008944)1.80885053
140Abnormality of the fovea (HP:0000493)1.80436982
141Occipital encephalocele (HP:0002085)1.80125742
142Abnormality of incisor morphology (HP:0011063)1.79962709
143Alacrima (HP:0000522)1.79378520
144Increased cerebral lipofuscin (HP:0011813)1.79118472
145Epileptic encephalopathy (HP:0200134)1.79084083
146Tubular atrophy (HP:0000092)1.78214878
147Poikilocytosis (HP:0004447)1.78135170
148Renal agenesis (HP:0000104)1.77986593
149Hyperkalemia (HP:0002153)1.77305578
150Colon cancer (HP:0003003)1.76690470
151Portal hypertension (HP:0001409)1.76256197
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76231633
153Anencephaly (HP:0002323)1.76100333
154Widely spaced teeth (HP:0000687)1.75974329
155Ulnar claw (HP:0001178)1.75012837
156Abnormality of abdominal situs (HP:0011620)1.74438019
157Abdominal situs inversus (HP:0003363)1.74438019
158Sloping forehead (HP:0000340)1.74372091
159Type I transferrin isoform profile (HP:0003642)1.74369453
160Nasolacrimal duct obstruction (HP:0000579)1.73211591
161Macular degeneration (HP:0000608)1.72788804
162Hypoplastic iliac wings (HP:0002866)1.72167667
163Decreased motor nerve conduction velocity (HP:0003431)1.71596945
164Abnormality of the lacrimal duct (HP:0011481)1.71457820
165Supranuclear gaze palsy (HP:0000605)1.71054643
166Abnormal respiratory epithelium morphology (HP:0012253)1.70888438
167Abnormal respiratory motile cilium morphology (HP:0005938)1.70888438
168Cupped ear (HP:0000378)1.69426091
169Morphological abnormality of the middle ear (HP:0008609)1.69141403
170Duplicated collecting system (HP:0000081)1.69089509
171Abnormality of the right ventricle (HP:0001707)1.68397087
172Stridor (HP:0010307)1.67858600
173Aplasia of the musculature (HP:0100854)1.67338385
174Abnormality of the septum pellucidum (HP:0007375)1.67123834
175Abnormality of the clitoris (HP:0000056)1.66998869
176Myelomeningocele (HP:0002475)1.66834901
177Abnormality of the renal cortex (HP:0011035)1.64587967
178Myokymia (HP:0002411)1.63964871
179Chronic otitis media (HP:0000389)1.63816551
180Keratoconjunctivitis (HP:0001096)1.63345518
181Hypoplasia of the uterus (HP:0000013)1.62856949
182Episodic fever (HP:0001954)1.60083937
183Pseudobulbar signs (HP:0002200)1.59621736
184Hypophosphatemic rickets (HP:0004912)1.58784012
185Hypokalemia (HP:0002900)1.57947605
186Cutaneous finger syndactyly (HP:0010554)1.57387924
187Spastic gait (HP:0002064)1.56910169
188Aortic regurgitation (HP:0001659)1.56862606
189Sex reversal (HP:0012245)1.56050847
190Abnormal sex determination (HP:0012244)1.56050847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.48226499
2PNCK4.80369055
3MUSK4.56446079
4STK393.56691768
5SIK33.41296682
6BMPR1B3.20083995
7ACVR1B3.13531375
8STK38L3.00650362
9OXSR12.99403535
10EIF2AK22.88311448
11CASK2.83063362
12CDK192.57665810
13EPHB12.39647992
14PIK3CG2.23074902
15INSRR2.22820762
16FER2.12830468
17CCNB12.03019083
18SIK21.92176991
19WNK31.89072731
20AKT31.88585213
21ADRBK21.85052237
22SIK11.73052358
23MKNK11.72993984
24PDK21.72659307
25BCR1.72368718
26SRPK11.67127708
27WNK41.65596448
28MAP2K41.60883702
29MAP2K31.59960180
30NTRK31.58119622
31CAMK1G1.57619244
32BMPR21.57305207
33EIF2AK11.56696041
34ZAK1.52177619
35FGR1.49852451
36EPHA41.49286949
37MAP2K61.49121045
38EPHB21.48497445
39PAK31.47917548
40EIF2AK31.46657407
41ERBB41.43916343
42TEC1.35433608
43PKN11.34022483
44TAOK31.31681637
45TNIK1.28120725
46STK31.24927837
47MAPK121.21717242
48NLK1.21127471
49MAP4K21.20771146
50STK381.13814820
51MAPK131.13413118
52MAPK71.11019147
53MST41.08905542
54OBSCN1.07249182
55PINK11.07235790
56MAPKAPK51.05363344
57SGK2231.03235406
58SGK4941.03235406
59ARAF1.03056237
60DAPK21.00715413
61TGFBR10.95696547
62ADRBK10.95647579
63MAP2K20.94944017
64WNK10.94364999
65PRKAA20.87828843
66CAMK2B0.85210073
67LATS10.84478707
68MARK20.84425669
69MELK0.83601039
70ERBB30.82998265
71RIPK40.81868482
72CAMK2A0.80676920
73PIK3CA0.79996780
74CAMK2G0.79468075
75MKNK20.78760062
76CAMK2D0.77061197
77NTRK10.75758113
78CAMKK20.75677701
79PTK2B0.73797157
80PRKCE0.72604095
81PAK40.72587571
82MAP3K40.71444220
83LIMK10.69154955
84ROCK20.69140753
85LATS20.67862225
86CAMK40.67133431
87MAP3K120.65839155
88PAK60.64997152
89MET0.64965491
90CSNK1A1L0.63950726
91PHKG10.63315813
92PHKG20.63315813
93DYRK1A0.62721154
94PRKCI0.62377919
95CDK50.61782569
96GRK70.61539254
97TRIM280.61048998
98PLK20.60834521
99ITK0.60360924
100YES10.59862376
101NTRK20.59854914
102MAP2K10.55325512
103CSNK1G10.54500750
104GRK50.52972174
105GRK10.52255050
106SGK20.49882411
107MAP3K130.49355436
108CDK140.49102300
109MAPKAPK30.48560167
110MAP3K140.47723858
111MAP2K70.47474639
112PLK40.46822095
113PRPF4B0.45109200
114KIT0.43686194
115BLK0.43592295
116CAMK10.43122746
117PRKCQ0.42901010
118PRKACA0.42421046
119MAP3K70.41670895
120GSK3A0.40939645
121TNK20.40693185
122SGK10.40143018
123BRSK20.39562472
124DMPK0.38285029
125NUAK10.37541459
126PRKG10.37414164
127CDK150.37296447
128NEK60.37205997
129FGFR20.36417520
130RPS6KA20.36357566
131CDK180.36103192
132RPS6KL10.35926378
133RPS6KC10.35926378
134CSNK1A10.34807008
135PLK30.33760968
136MARK30.33328655
137MARK10.32916082
138PRKCG0.32817130
139MYLK0.32750504
140TRPM70.31698604
141CSNK1D0.31553730
142ABL10.31268852
143NEK90.31114908
144ROCK10.30657410
145CSNK1G30.30250448
146TIE10.30202348
147IKBKE0.29471246
148PRKACB0.29452412
149CDK11A0.29233953
150UHMK10.28954127
151PRKAA10.28934632
152IKBKB0.27882612
153DYRK20.27873025
154SGK30.25547413
155PRKD10.24218382

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001403.51007569
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.10201369
3Fatty acid elongation_Homo sapiens_hsa000622.85868755
4Steroid biosynthesis_Homo sapiens_hsa001002.78535022
5Aldosterone synthesis and secretion_Homo sapiens_hsa049252.71891913
6Butanoate metabolism_Homo sapiens_hsa006502.62998463
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62963419
8ABC transporters_Homo sapiens_hsa020102.57096410
9Tryptophan metabolism_Homo sapiens_hsa003802.36480139
10Ovarian steroidogenesis_Homo sapiens_hsa049132.35735754
11Taste transduction_Homo sapiens_hsa047422.32577028
12Nicotine addiction_Homo sapiens_hsa050332.28851964
13Axon guidance_Homo sapiens_hsa043602.22433256
14Dorso-ventral axis formation_Homo sapiens_hsa043202.15374214
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.11049933
16Morphine addiction_Homo sapiens_hsa050322.05598043
17Homologous recombination_Homo sapiens_hsa034402.05455157
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.02254555
19Renin secretion_Homo sapiens_hsa049241.89669684
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88613190
21* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87191215
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83312195
23Non-homologous end-joining_Homo sapiens_hsa034501.81545152
24Nitrogen metabolism_Homo sapiens_hsa009101.72845748
25Serotonergic synapse_Homo sapiens_hsa047261.67186669
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65001680
27Fanconi anemia pathway_Homo sapiens_hsa034601.64152957
28Propanoate metabolism_Homo sapiens_hsa006401.61127938
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60304386
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.59341101
31Vitamin digestion and absorption_Homo sapiens_hsa049771.55574779
32Circadian entrainment_Homo sapiens_hsa047131.51514678
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49504687
34Glutamatergic synapse_Homo sapiens_hsa047241.46154245
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45420393
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42226684
37GABAergic synapse_Homo sapiens_hsa047271.41198085
38Salivary secretion_Homo sapiens_hsa049701.39155089
39Autoimmune thyroid disease_Homo sapiens_hsa053201.37527646
40Amphetamine addiction_Homo sapiens_hsa050311.35652987
41Gastric acid secretion_Homo sapiens_hsa049711.32662151
42Ether lipid metabolism_Homo sapiens_hsa005651.32498120
43One carbon pool by folate_Homo sapiens_hsa006701.31240056
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29647403
45Lysine degradation_Homo sapiens_hsa003101.25658363
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21534883
47Dopaminergic synapse_Homo sapiens_hsa047281.19916507
48Glycerolipid metabolism_Homo sapiens_hsa005611.18601542
49Fatty acid degradation_Homo sapiens_hsa000711.18012830
50Chemical carcinogenesis_Homo sapiens_hsa052041.17047050
51* Calcium signaling pathway_Homo sapiens_hsa040201.16405006
52Cholinergic synapse_Homo sapiens_hsa047251.13243123
53Mineral absorption_Homo sapiens_hsa049781.11665258
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10666410
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09551446
56Long-term potentiation_Homo sapiens_hsa047201.08769685
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06731080
58Olfactory transduction_Homo sapiens_hsa047401.05105927
59Circadian rhythm_Homo sapiens_hsa047101.03752191
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03307649
61beta-Alanine metabolism_Homo sapiens_hsa004101.03064474
62Prion diseases_Homo sapiens_hsa050201.02655587
63Sphingolipid metabolism_Homo sapiens_hsa006001.02181479
64Long-term depression_Homo sapiens_hsa047301.01940963
65cAMP signaling pathway_Homo sapiens_hsa040241.01624767
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00333817
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99633266
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95988684
69Selenocompound metabolism_Homo sapiens_hsa004500.93568671
70Sulfur metabolism_Homo sapiens_hsa009200.92688147
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91724402
72Basal transcription factors_Homo sapiens_hsa030220.91292061
73Bile secretion_Homo sapiens_hsa049760.90780369
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90625680
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.89904877
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87672889
77Oxytocin signaling pathway_Homo sapiens_hsa049210.86568758
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84937279
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84685600
80Caffeine metabolism_Homo sapiens_hsa002320.83746298
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83179506
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.82991564
83Synaptic vesicle cycle_Homo sapiens_hsa047210.81736395
84Collecting duct acid secretion_Homo sapiens_hsa049660.80105129
85ErbB signaling pathway_Homo sapiens_hsa040120.79312003
86Rheumatoid arthritis_Homo sapiens_hsa053230.76916212
87Fatty acid metabolism_Homo sapiens_hsa012120.76412452
88Linoleic acid metabolism_Homo sapiens_hsa005910.75408276
89Tyrosine metabolism_Homo sapiens_hsa003500.74790795
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72914097
91Ras signaling pathway_Homo sapiens_hsa040140.72255552
92Allograft rejection_Homo sapiens_hsa053300.71680619
93African trypanosomiasis_Homo sapiens_hsa051430.71212716
94Glutathione metabolism_Homo sapiens_hsa004800.70550264
95Fatty acid biosynthesis_Homo sapiens_hsa000610.70194140
96Arginine and proline metabolism_Homo sapiens_hsa003300.69493003
97Regulation of autophagy_Homo sapiens_hsa041400.67349205
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66708891
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65143798
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64870937
101Insulin secretion_Homo sapiens_hsa049110.63530423
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.63369520
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62182237
104MAPK signaling pathway_Homo sapiens_hsa040100.61517192
105Notch signaling pathway_Homo sapiens_hsa043300.61438928
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60813855
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.60158678
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.57603749
109Type II diabetes mellitus_Homo sapiens_hsa049300.57254240
110PPAR signaling pathway_Homo sapiens_hsa033200.56247592
111Pancreatic secretion_Homo sapiens_hsa049720.55675268
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55550258
113Histidine metabolism_Homo sapiens_hsa003400.53759938
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50857515
115Peroxisome_Homo sapiens_hsa041460.49434018
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48392534
117Melanoma_Homo sapiens_hsa052180.48331195
118N-Glycan biosynthesis_Homo sapiens_hsa005100.48040176
119Phototransduction_Homo sapiens_hsa047440.47949116
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46882631
121Wnt signaling pathway_Homo sapiens_hsa043100.46779402
122Fat digestion and absorption_Homo sapiens_hsa049750.46286748
123Cocaine addiction_Homo sapiens_hsa050300.43229979
124Vibrio cholerae infection_Homo sapiens_hsa051100.42520329
125Purine metabolism_Homo sapiens_hsa002300.42372890
126Platelet activation_Homo sapiens_hsa046110.42296432
127Gap junction_Homo sapiens_hsa045400.41996913
128Alzheimers disease_Homo sapiens_hsa050100.41918452
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39877448
130Protein export_Homo sapiens_hsa030600.39765704
131Insulin resistance_Homo sapiens_hsa049310.39075044
132Melanogenesis_Homo sapiens_hsa049160.38202739
133Rap1 signaling pathway_Homo sapiens_hsa040150.37388319
134Retinol metabolism_Homo sapiens_hsa008300.36689962
135Metabolic pathways_Homo sapiens_hsa011000.36202148
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.35961581
137Dilated cardiomyopathy_Homo sapiens_hsa054140.35846285
138ECM-receptor interaction_Homo sapiens_hsa045120.34977731
139Arachidonic acid metabolism_Homo sapiens_hsa005900.34646865
140Renal cell carcinoma_Homo sapiens_hsa052110.33842001
141Inositol phosphate metabolism_Homo sapiens_hsa005620.33508322
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33444837
143FoxO signaling pathway_Homo sapiens_hsa040680.32897828
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31574132
145Thyroid hormone synthesis_Homo sapiens_hsa049180.29147825
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.27351431

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