TACR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte chemotaxis (GO:0002689)8.60892262
2regulation of chemokine-mediated signaling pathway (GO:0070099)8.10150113
3regulation of inhibitory postsynaptic membrane potential (GO:0060080)8.04373050
4axon extension involved in axon guidance (GO:0048846)7.84335389
5neuron projection extension involved in neuron projection guidance (GO:1902284)7.84335389
6adaptation of signaling pathway (GO:0023058)7.77237927
7positive regulation of synaptic transmission, GABAergic (GO:0032230)6.61845567
8regulation of dopamine secretion (GO:0014059)6.36245411
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.28095565
10negative regulation of vascular permeability (GO:0043116)6.05908541
11negative regulation of axon guidance (GO:1902668)6.03954203
12regulation of mononuclear cell migration (GO:0071675)6.03933594
13mating behavior (GO:0007617)5.87815832
14negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.34729286
15membrane hyperpolarization (GO:0060081)5.33020286
16regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21030573
17neuron-neuron synaptic transmission (GO:0007270)5.11066367
18synaptic transmission, glutamatergic (GO:0035249)5.04743607
19synaptic vesicle exocytosis (GO:0016079)5.03213075
20behavioral response to nicotine (GO:0035095)4.84921589
21dopamine biosynthetic process (GO:0042416)4.77151371
22protein localization to synapse (GO:0035418)4.74733713
23positive regulation of amino acid transport (GO:0051957)4.74030975
24neuromuscular process controlling posture (GO:0050884)4.70749296
25detection of light stimulus involved in visual perception (GO:0050908)4.65978171
26detection of light stimulus involved in sensory perception (GO:0050962)4.65978171
27negative regulation of smooth muscle cell migration (GO:0014912)4.65355399
28regulation of axon guidance (GO:1902667)4.63469333
29synaptic vesicle endocytosis (GO:0048488)4.49279042
30regulation of synaptic vesicle exocytosis (GO:2000300)4.45333100
31synaptic vesicle maturation (GO:0016188)4.41488504
32presynaptic membrane assembly (GO:0097105)4.38670604
33ionotropic glutamate receptor signaling pathway (GO:0035235)4.37968078
34neuron cell-cell adhesion (GO:0007158)4.37741753
35regulation of monocyte chemotaxis (GO:0090025)4.22884105
36glutamate secretion (GO:0014047)4.22337070
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21526625
38short-term memory (GO:0007614)4.12308303
39dopamine transport (GO:0015872)4.10016824
40regulation of gene silencing by RNA (GO:0060966)4.08585624
41regulation of posttranscriptional gene silencing (GO:0060147)4.08585624
42regulation of gene silencing by miRNA (GO:0060964)4.08585624
43regulation of meiosis I (GO:0060631)3.90351770
44negative regulation of axon extension (GO:0030517)3.87207692
45cell migration involved in sprouting angiogenesis (GO:0002042)3.82753073
46auditory behavior (GO:0031223)3.82243503
47regulation of DNA methylation (GO:0044030)3.82160846
48presynaptic membrane organization (GO:0097090)3.81850847
49cellular potassium ion homeostasis (GO:0030007)3.81380466
50motor neuron axon guidance (GO:0008045)3.77526197
51glutamate receptor signaling pathway (GO:0007215)3.76800004
52histone H4-K12 acetylation (GO:0043983)3.74388431
53regulation of synaptic vesicle transport (GO:1902803)3.73900112
54regulation of postsynaptic membrane potential (GO:0060078)3.72275976
55regulation of catecholamine secretion (GO:0050433)3.71219633
56response to histamine (GO:0034776)3.70283595
57neurotransmitter secretion (GO:0007269)3.69268103
58startle response (GO:0001964)3.68616176
59righting reflex (GO:0060013)3.68184417
60synaptic transmission, cholinergic (GO:0007271)3.67522333
61neurotransmitter catabolic process (GO:0042135)3.62862393
62retinal ganglion cell axon guidance (GO:0031290)3.62841556
63innervation (GO:0060384)3.62128714
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.60637842
65response to auditory stimulus (GO:0010996)3.59068232
66regulation of synaptic transmission, GABAergic (GO:0032228)3.53309876
67serotonin metabolic process (GO:0042428)3.50576700
68retinal cone cell development (GO:0046549)3.49958120
69catecholamine transport (GO:0051937)3.48653487
70chromatin remodeling at centromere (GO:0031055)3.48144661
71activation of protein kinase A activity (GO:0034199)3.47644888
72regulation of transmission of nerve impulse (GO:0051969)3.46151166
73CENP-A containing nucleosome assembly (GO:0034080)3.45040201
74vocalization behavior (GO:0071625)3.43835751
75locomotory exploration behavior (GO:0035641)3.41243212
76long-term memory (GO:0007616)3.40158909
77membrane depolarization (GO:0051899)3.39077350
78neurotransmitter transport (GO:0006836)3.36130884
79regulation of neurotransmitter levels (GO:0001505)3.35798959
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35411139
81synaptic transmission, dopaminergic (GO:0001963)3.33051713
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31029505
83behavioral response to cocaine (GO:0048148)3.30489658
84positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.29877152
85regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.29877152
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29830198
87positive regulation of neurotransmitter transport (GO:0051590)3.27176595
88prepulse inhibition (GO:0060134)3.23628428
89negative chemotaxis (GO:0050919)3.22351302
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20967409
91establishment of synaptic vesicle localization (GO:0097480)3.20835070
92synaptic vesicle transport (GO:0048489)3.20835070
93regulation of amino acid transport (GO:0051955)3.19616989
94positive regulation of neurotransmitter secretion (GO:0001956)3.18930952
95synaptic vesicle docking involved in exocytosis (GO:0016081)3.17558874
96exploration behavior (GO:0035640)3.17192692
97positive regulation of dendritic spine morphogenesis (GO:0061003)3.16931244
98cochlea development (GO:0090102)3.16682415
99establishment of protein localization to mitochondrial membrane (GO:0090151)3.16272356
100regulation of amine transport (GO:0051952)3.13591989
101histone H2A acetylation (GO:0043968)3.11661307
102positive regulation of histone H3-K4 methylation (GO:0051571)3.10076218
103piRNA metabolic process (GO:0034587)3.07498394
104positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.06390984
105positive regulation of cell cycle G2/M phase transition (GO:1902751)3.06390984
106regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05313611
107inner ear receptor cell development (GO:0060119)3.04760636
108G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04306019
109primitive streak formation (GO:0090009)3.02727666
110positive regulation of mRNA processing (GO:0050685)3.00610854
111synaptic transmission (GO:0007268)2.99345778
112meiotic cell cycle (GO:0051321)2.98920146
113primary amino compound metabolic process (GO:1901160)2.97806635
114* regulation of catecholamine metabolic process (GO:0042069)2.97331933
115* regulation of dopamine metabolic process (GO:0042053)2.97331933
116axon extension (GO:0048675)2.96193124
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96107658
118regulation of mitotic spindle checkpoint (GO:1903504)2.96107658
119paraxial mesoderm development (GO:0048339)2.95902511
120mechanosensory behavior (GO:0007638)2.94554546
121regulation of calcium ion-dependent exocytosis (GO:0017158)2.94554539
122regulation of glutamate receptor signaling pathway (GO:1900449)2.94464333
123histone exchange (GO:0043486)2.91850519
124neuron recognition (GO:0008038)2.91590556
125regulation of cofactor metabolic process (GO:0051193)2.90699429
126regulation of coenzyme metabolic process (GO:0051196)2.90699429
127positive regulation of amine transport (GO:0051954)2.90471809
128neurotransmitter-gated ion channel clustering (GO:0072578)2.89283479
129response to insecticide (GO:0017085)2.89028279
130synapse assembly (GO:0007416)2.88861999
131chaperone-mediated protein complex assembly (GO:0051131)2.88774062
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88387669
133regulation of neuronal synaptic plasticity (GO:0048168)2.88150653
134gamma-aminobutyric acid transport (GO:0015812)2.87734403
135positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.86898445
136regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.86898445
137alkaloid metabolic process (GO:0009820)2.86693440
138pyrimidine nucleobase catabolic process (GO:0006208)2.86670924
139regulation of histone H3-K9 methylation (GO:0051570)2.85623851
140nonmotile primary cilium assembly (GO:0035058)2.84598387
141DNA replication-independent nucleosome organization (GO:0034724)2.83072320
142DNA replication-independent nucleosome assembly (GO:0006336)2.83072320
143neuronal action potential (GO:0019228)2.82090503
144positive regulation of dendritic spine development (GO:0060999)2.79194936
145postsynaptic membrane organization (GO:0001941)2.74710463
146negative regulation of DNA-dependent DNA replication (GO:2000104)2.72568097
147chaperone-mediated protein transport (GO:0072321)2.70816507
148RNA destabilization (GO:0050779)2.70346341
149telomere maintenance via telomerase (GO:0007004)2.69358079
150negative regulation of gene silencing (GO:0060969)2.67427726
151DNA replication-dependent nucleosome organization (GO:0034723)2.66632626
152DNA replication-dependent nucleosome assembly (GO:0006335)2.66632626
153positive regulation of mRNA 3-end processing (GO:0031442)2.65825167
154multicellular organism reproduction (GO:0032504)2.65471796
155positive regulation of gastrulation (GO:2000543)2.65438176
156regulation of female gonad development (GO:2000194)2.63328888
157protein neddylation (GO:0045116)2.57159511
158mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56473252
159catechol-containing compound biosynthetic process (GO:0009713)2.56320648
160catecholamine biosynthetic process (GO:0042423)2.56320648
161organ growth (GO:0035265)2.54953915
162DNA replication checkpoint (GO:0000076)2.53248155
163regulation of mitochondrial translation (GO:0070129)2.51993700
164peristalsis (GO:0030432)2.51008157
165ATP synthesis coupled proton transport (GO:0015986)2.50595560
166energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50595560
167lateral sprouting from an epithelium (GO:0060601)2.48034429
168positive regulation of histone methylation (GO:0031062)2.46355503
169positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.46068542
170otic vesicle formation (GO:0030916)2.45161956
171central nervous system projection neuron axonogenesis (GO:0021952)2.44470825
172spliceosomal snRNP assembly (GO:0000387)2.41402765
173negative regulation of histone methylation (GO:0031061)2.40227252
174regulation of gene silencing (GO:0060968)2.39561969
175regulation of mRNA 3-end processing (GO:0031440)2.36856251
176centriole replication (GO:0007099)2.36585022
177maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.34656424
178pre-miRNA processing (GO:0031054)2.34437638
179establishment of integrated proviral latency (GO:0075713)2.33652374
180inner mitochondrial membrane organization (GO:0007007)2.32944084
181G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.32549555
182female gamete generation (GO:0007292)2.31204068
183positive regulation of mRNA metabolic process (GO:1903313)2.29832424
184synapsis (GO:0007129)2.29378433
185regulation of timing of cell differentiation (GO:0048505)2.28863290
186regulation of translation, ncRNA-mediated (GO:0045974)2.28813622
187response to pheromone (GO:0019236)13.5093470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.24951891
2EZH2_22144423_ChIP-Seq_EOC_Human4.52617212
3GBX2_23144817_ChIP-Seq_PC3_Human4.14009670
4TAF15_26573619_Chip-Seq_HEK293_Human3.22376176
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17974720
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10036109
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07578432
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.02021788
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92917852
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76586796
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64474970
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.58785842
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57582242
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57496192
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57496192
16REST_21632747_ChIP-Seq_MESCs_Mouse2.39615310
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35912971
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35562214
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32398679
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25320987
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23002856
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20974213
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.18788274
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17161755
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.12743424
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09001871
27DROSHA_22980978_ChIP-Seq_HELA_Human2.01827593
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01789544
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.01174171
30VDR_22108803_ChIP-Seq_LS180_Human2.01134153
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99906688
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.99681943
33ZNF274_21170338_ChIP-Seq_K562_Hela1.91772119
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.85310336
35* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83446876
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83337006
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80090115
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.75819728
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.74787551
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73419968
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69092628
42* EWS_26573619_Chip-Seq_HEK293_Human1.67188908
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65648127
44* P300_19829295_ChIP-Seq_ESCs_Human1.64558968
45SMAD4_21799915_ChIP-Seq_A2780_Human1.60499038
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59060542
47BCAT_22108803_ChIP-Seq_LS180_Human1.55163273
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53887144
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51519911
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48293184
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48143746
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44731302
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44731302
54ZNF263_19887448_ChIP-Seq_K562_Human1.44233705
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.44078103
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42971398
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40671821
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39017359
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36554682
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36554682
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36554682
62E2F7_22180533_ChIP-Seq_HELA_Human1.36164312
63TP53_16413492_ChIP-PET_HCT116_Human1.35672889
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34939500
65AR_25329375_ChIP-Seq_VCAP_Human1.33226553
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31501237
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.25541438
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25157040
69AR_21572438_ChIP-Seq_LNCaP_Human1.24472472
70FUS_26573619_Chip-Seq_HEK293_Human1.21377726
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20206980
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19319828
73IGF1R_20145208_ChIP-Seq_DFB_Human1.19240065
74* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19205659
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.17868509
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17342912
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.16965899
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15996518
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15864929
80CBP_20019798_ChIP-Seq_JUKART_Human1.15820020
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15820020
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15168930
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14608835
84STAT3_23295773_ChIP-Seq_U87_Human1.14276715
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14180132
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13721136
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13717356
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12412125
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10952360
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.10829276
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.10666006
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.09197935
93* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09044187
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08431370
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07755043
96* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07529739
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04446285
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03561514
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03512947
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03260464
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02914300
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02390919
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01500637
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.01470720
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99712541
106SOX9_26525672_Chip-Seq_HEART_Mouse0.98232460
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97733965
108CBX2_27304074_Chip-Seq_ESCs_Mouse0.97397141
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.97378514
110* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97143633
111ER_23166858_ChIP-Seq_MCF-7_Human0.96518623
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96182227
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.95904141
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95872212
115* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95686236
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.95571106
117TCF4_22108803_ChIP-Seq_LS180_Human0.95475304
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94856320
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94726656
120AR_19668381_ChIP-Seq_PC3_Human0.93542544
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93165138
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92910855
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92761779
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91095331
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91022143
126* RUNX2_22187159_ChIP-Seq_PCA_Human0.90114969
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89357411
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89104191
129TCF4_23295773_ChIP-Seq_U87_Human0.88901945
130FLI1_21867929_ChIP-Seq_TH2_Mouse0.88610208
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.87921185
132STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87134985
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86555394
134* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86269993
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.85009003
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.84312229
137* SMAD3_21741376_ChIP-Seq_ESCs_Human0.83312850
138RNF2_27304074_Chip-Seq_NSC_Mouse0.82183801
139JUN_21703547_ChIP-Seq_K562_Human0.81394373
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80468018
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79978600
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79742651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.56591502
2MP0004859_abnormal_synaptic_plasticity4.42153872
3MP0002735_abnormal_chemical_nociception4.02627410
4MP0003635_abnormal_synaptic_transmissio3.89763184
5MP0005423_abnormal_somatic_nervous3.39015381
6MP0005551_abnormal_eye_electrophysiolog3.04811104
7MP0002064_seizures3.01091154
8MP0006292_abnormal_olfactory_placode2.94595362
9MP0001486_abnormal_startle_reflex2.91463799
10MP0009046_muscle_twitch2.81024989
11MP0002272_abnormal_nervous_system2.80489279
12MP0001968_abnormal_touch/_nociception2.73601414
13MP0009745_abnormal_behavioral_response2.69748087
14MP0003890_abnormal_embryonic-extraembry2.68097976
15MP0008877_abnormal_DNA_methylation2.62195522
16MP0003718_maternal_effect2.60330166
17MP0001905_abnormal_dopamine_level2.54702814
18MP0003941_abnormal_skin_development2.54086573
19* MP0002063_abnormal_learning/memory/cond2.51782115
20MP0004270_analgesia2.50779593
21MP0006276_abnormal_autonomic_nervous2.49410010
22MP0002736_abnormal_nociception_after2.39430473
23MP0000534_abnormal_ureter_morphology2.37576596
24MP0002090_abnormal_vision2.35112979
25MP0001529_abnormal_vocalization2.34445538
26MP0000566_synostosis2.27877147
27MP0001440_abnormal_grooming_behavior2.21151286
28* MP0002572_abnormal_emotion/affect_behav2.17175079
29MP0002733_abnormal_thermal_nociception2.14354597
30MP0001970_abnormal_pain_threshold2.08863156
31MP0003121_genomic_imprinting2.07052426
32MP0002909_abnormal_adrenal_gland2.04661087
33MP0002822_catalepsy2.01150274
34MP0001501_abnormal_sleep_pattern1.96658440
35MP0002734_abnormal_mechanical_nocicepti1.92218456
36MP0010030_abnormal_orbit_morphology1.86945973
37MP0004858_abnormal_nervous_system1.86072777
38MP0008789_abnormal_olfactory_epithelium1.86054694
39MP0002067_abnormal_sensory_capabilities1.80429262
40MP0003136_yellow_coat_color1.78191108
41MP0001293_anophthalmia1.75780153
42MP0002184_abnormal_innervation1.69885076
43MP0005386_behavior/neurological_phenoty1.67835708
44MP0004924_abnormal_behavior1.67835708
45MP0003329_amyloid_beta_deposits1.67609231
46MP0009379_abnormal_foot_pigmentation1.65819829
47MP0003119_abnormal_digestive_system1.61175419
48MP0003122_maternal_imprinting1.59894544
49MP0001502_abnormal_circadian_rhythm1.52761873
50MP0000579_abnormal_nail_morphology1.47225320
51MP0002557_abnormal_social/conspecific_i1.45677917
52MP0000372_irregular_coat_pigmentation1.44742419
53MP0004133_heterotaxia1.44213545
54MP0008872_abnormal_physiological_respon1.41210478
55MP0003693_abnormal_embryo_hatching1.40884328
56MP0002882_abnormal_neuron_morphology1.37478757
57MP0001346_abnormal_lacrimal_gland1.36617618
58MP0002066_abnormal_motor_capabilities/c1.36066221
59MP0003937_abnormal_limbs/digits/tail_de1.35944227
60MP0002233_abnormal_nose_morphology1.32921299
61MP0005377_hearing/vestibular/ear_phenot1.32016250
62MP0003878_abnormal_ear_physiology1.32016250
63MP0002638_abnormal_pupillary_reflex1.31791477
64MP0009672_abnormal_birth_weight1.31057124
65MP0004142_abnormal_muscle_tone1.30969638
66MP0004885_abnormal_endolymph1.28448702
67MP0000955_abnormal_spinal_cord1.28330728
68MP0005623_abnormal_meninges_morphology1.25839793
69MP0003633_abnormal_nervous_system1.25481266
70MP0004957_abnormal_blastocyst_morpholog1.23798206
71MP0004811_abnormal_neuron_physiology1.23409080
72MP0005171_absent_coat_pigmentation1.22295263
73MP0008961_abnormal_basal_metabolism1.18998175
74MP0002229_neurodegeneration1.18765838
75MP0003942_abnormal_urinary_system1.18691219
76MP0002751_abnormal_autonomic_nervous1.18238358
77MP0010368_abnormal_lymphatic_system1.18106800
78MP0009697_abnormal_copulation1.18067620
79MP0006072_abnormal_retinal_apoptosis1.18007896
80MP0002138_abnormal_hepatobiliary_system1.17871199
81MP0002160_abnormal_reproductive_system1.16824909
82MP0000631_abnormal_neuroendocrine_gland1.16711203
83MP0002210_abnormal_sex_determination1.14803730
84MP0003631_nervous_system_phenotype1.13343449
85MP0000049_abnormal_middle_ear1.13040537
86MP0002938_white_spotting1.12725599
87MP0005187_abnormal_penis_morphology1.12420738
88MP0005535_abnormal_body_temperature1.11990267
89MP0000639_abnormal_adrenal_gland1.10287281
90MP0002102_abnormal_ear_morphology1.09294602
91MP0003879_abnormal_hair_cell1.08732806
92MP0000537_abnormal_urethra_morphology1.06998267
93MP0004510_myositis1.05556971
94MP0005253_abnormal_eye_physiology1.05464077
95MP0000778_abnormal_nervous_system1.05212327
96MP0003938_abnormal_ear_development1.05135310
97MP0008569_lethality_at_weaning1.04583724
98MP0003787_abnormal_imprinting1.03939314
99MP0003567_abnormal_fetal_cardiomyocyte1.03346025
100MP0008057_abnormal_DNA_replication1.02786795
101MP0002752_abnormal_somatic_nervous1.02238555
102MP0009703_decreased_birth_body1.02219591
103MP0001485_abnormal_pinna_reflex0.99535930
104MP0002234_abnormal_pharynx_morphology0.98947850
105MP0003861_abnormal_nervous_system0.98751112
106MP0005195_abnormal_posterior_eye0.97833593
107MP0002277_abnormal_respiratory_mucosa0.97538276
108MP0005395_other_phenotype0.97315883
109MP0001929_abnormal_gametogenesis0.97139686
110MP0002697_abnormal_eye_size0.96546239
111MP0003172_abnormal_lysosome_physiology0.95372477
112MP0003632_abnormal_nervous_system0.95358966
113MP0001286_abnormal_eye_development0.95250940
114MP0003698_abnormal_male_reproductive0.94772221
115MP0002152_abnormal_brain_morphology0.94562319
116MP0003077_abnormal_cell_cycle0.93147261
117MP0005499_abnormal_olfactory_system0.92134765
118MP0005394_taste/olfaction_phenotype0.92134765
119MP0001984_abnormal_olfaction0.90858869
120MP0000653_abnormal_sex_gland0.88624359
121MP0003315_abnormal_perineum_morphology0.87158534
122MP0005084_abnormal_gallbladder_morpholo0.86893640
123MP0008874_decreased_physiological_sensi0.86863061
124MP0003868_abnormal_feces_composition0.86711533
125MP0002332_abnormal_exercise_endurance0.85695600
126MP0000013_abnormal_adipose_tissue0.85555581
127MP0002161_abnormal_fertility/fecundity0.84436612
128MP0002876_abnormal_thyroid_physiology0.82702991
129MP0005646_abnormal_pituitary_gland0.82313144
130MP0001177_atelectasis0.80061444
131MP0004145_abnormal_muscle_electrophysio0.78920046
132MP0003634_abnormal_glial_cell0.77877241
133MP0002069_abnormal_eating/drinking_beha0.76906422
134MP0010386_abnormal_urinary_bladder0.75337040
135MP0001664_abnormal_digestion0.73086251
136MP0000751_myopathy0.71184143
137MP0002837_dystrophic_cardiac_calcinosis0.69906024
138MP0004085_abnormal_heartbeat0.68583835
139MP0005410_abnormal_fertilization0.68441381
140MP0005248_abnormal_Harderian_gland0.68227990
141MP0001188_hyperpigmentation0.67179661
142MP0003283_abnormal_digestive_organ0.67060783
143MP0002653_abnormal_ependyma_morphology0.66847628
144MP0003950_abnormal_plasma_membrane0.66570224
145MP0000604_amyloidosis0.65680462
146MP0000920_abnormal_myelination0.65203052
147MP0001963_abnormal_hearing_physiology0.64968434
148MP0005645_abnormal_hypothalamus_physiol0.64159018
149MP0004742_abnormal_vestibular_system0.63297575
150MP0004215_abnormal_myocardial_fiber0.63180471
151MP0001943_abnormal_respiration0.62651059
152MP0005409_darkened_coat_color0.59197394

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.40433849
2Limb dystonia (HP:0002451)5.49654919
3Focal seizures (HP:0007359)5.48069704
4Visual hallucinations (HP:0002367)5.35010006
5Atonic seizures (HP:0010819)5.07003271
6Congenital stationary night blindness (HP:0007642)4.80326544
7Febrile seizures (HP:0002373)4.51627719
8Absence seizures (HP:0002121)4.50962017
9Dialeptic seizures (HP:0011146)4.38592147
10Potter facies (HP:0002009)4.30763171
11Facial shape deformation (HP:0011334)4.30763171
12Epileptic encephalopathy (HP:0200134)4.15140655
13Pheochromocytoma (HP:0002666)3.88072447
14Myokymia (HP:0002411)3.80719968
15Generalized tonic-clonic seizures (HP:0002069)3.72204939
16Decreased central vision (HP:0007663)3.69958415
17Distal arthrogryposis (HP:0005684)3.60337852
18Septo-optic dysplasia (HP:0100842)3.33840332
19Central scotoma (HP:0000603)3.31073131
20Abnormality of binocular vision (HP:0011514)3.29494589
21Diplopia (HP:0000651)3.29494589
22Neoplasm of the heart (HP:0100544)3.23229893
23Neuroendocrine neoplasm (HP:0100634)3.17524617
24Progressive cerebellar ataxia (HP:0002073)3.15946075
25Abnormality of macular pigmentation (HP:0008002)3.10170579
26Urinary bladder sphincter dysfunction (HP:0002839)2.97732803
27Acute lymphatic leukemia (HP:0006721)2.97722360
28Cone-rod dystrophy (HP:0000548)2.86452704
29Cerebral inclusion bodies (HP:0100314)2.81989348
30Failure to thrive in infancy (HP:0001531)2.75874724
31Optic nerve hypoplasia (HP:0000609)2.74966041
32Abnormality of alanine metabolism (HP:0010916)2.71417170
33Hyperalaninemia (HP:0003348)2.71417170
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71417170
35Hemiparesis (HP:0001269)2.68597748
36Hypothermia (HP:0002045)2.68520393
37Maternal diabetes (HP:0009800)2.67122706
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67120461
39EEG with generalized epileptiform discharges (HP:0011198)2.66720171
40Epileptiform EEG discharges (HP:0011182)2.65224712
41Abnormal eating behavior (HP:0100738)2.61593309
42Polyphagia (HP:0002591)2.55969090
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.55268175
44Hypokinesia (HP:0002375)2.54291299
45Hypoplastic nipples (HP:0002557)2.49730253
46Spastic gait (HP:0002064)2.48042579
47Abnormality of the parathyroid morphology (HP:0011766)2.42378875
48Absent septum pellucidum (HP:0001331)2.42360288
49Poor suck (HP:0002033)2.41057523
50Supernumerary spleens (HP:0009799)2.40613374
51Morphological abnormality of the pyramidal tract (HP:0002062)2.38039137
52Truncal ataxia (HP:0002078)2.36265223
53Scotoma (HP:0000575)2.35426785
54Bilateral microphthalmos (HP:0007633)2.35278188
55Hepatoblastoma (HP:0002884)2.34403345
56Mutism (HP:0002300)2.33951434
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.32543739
58Hypoplasia of the fovea (HP:0007750)2.32543739
59Colon cancer (HP:0003003)2.31519341
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.31502585
61Gait imbalance (HP:0002141)2.31290963
62Abnormality of abdominal situs (HP:0011620)2.29974643
63Abdominal situs inversus (HP:0003363)2.29974643
64Hypoventilation (HP:0002791)2.28559342
65Tubulointerstitial fibrosis (HP:0005576)2.27393589
66Hypsarrhythmia (HP:0002521)2.24065452
67Oligodactyly (hands) (HP:0001180)2.21916406
68Generalized aminoaciduria (HP:0002909)2.21119769
69Abnormal gallbladder physiology (HP:0012438)2.19836231
70Cholecystitis (HP:0001082)2.19836231
71Ankle clonus (HP:0011448)2.19650076
72Anxiety (HP:0000739)2.17616956
73Postural tremor (HP:0002174)2.15727445
74Hemiplegia (HP:0002301)2.15290964
75Supranuclear gaze palsy (HP:0000605)2.14778438
76Increased cerebral lipofuscin (HP:0011813)2.14162510
77Aqueductal stenosis (HP:0002410)2.13794741
78Midline defect of the nose (HP:0004122)2.13008391
79Abnormality of the septum pellucidum (HP:0007375)2.11891159
80Ependymoma (HP:0002888)2.10891881
81Esophageal atresia (HP:0002032)2.09722689
82Depressed nasal tip (HP:0000437)2.09396163
83Osteomalacia (HP:0002749)2.07206013
84Medial flaring of the eyebrow (HP:0010747)2.07007332
85Growth hormone deficiency (HP:0000824)2.06420374
86Gastrointestinal atresia (HP:0002589)2.05228867
87Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.04834051
88Cutaneous syndactyly (HP:0012725)2.04797731
89Abolished electroretinogram (ERG) (HP:0000550)2.04347531
90Astrocytoma (HP:0009592)2.04116501
91Abnormality of the astrocytes (HP:0100707)2.04116501
92Rigidity (HP:0002063)2.02839936
93Decreased muscle mass (HP:0003199)2.02451789
94Abnormal rod and cone electroretinograms (HP:0008323)2.01664761
95Congenital primary aphakia (HP:0007707)2.01449411
96Abnormal lung lobation (HP:0002101)2.01197861
97Diminished movement (HP:0002374)2.01186684
98Clumsiness (HP:0002312)2.00512902
99Hyperglycinemia (HP:0002154)2.00256873
100Abnormality of the fovea (HP:0000493)1.99509931
101Broad-based gait (HP:0002136)1.99153650
102Abnormality of calcium-phosphate metabolism (HP:0100530)1.98451409
103Status epilepticus (HP:0002133)1.98403090
104Bony spicule pigmentary retinopathy (HP:0007737)1.98131257
105Genital tract atresia (HP:0001827)1.97654115
106Depression (HP:0000716)1.97626607
107Neurofibrillary tangles (HP:0002185)1.97477601
108Severe visual impairment (HP:0001141)1.97348126
109Atelectasis (HP:0100750)1.96510706
110Intestinal atresia (HP:0011100)1.95991145
111Vaginal atresia (HP:0000148)1.95571096
112Gonadotropin excess (HP:0000837)1.93989669
113Partial duplication of thumb phalanx (HP:0009944)1.92700535
114Absent eyebrow (HP:0002223)1.92676456
115Pancreatic cysts (HP:0001737)1.92535291
116Abnormality of ocular smooth pursuit (HP:0000617)1.90942342
117Muscular hypotonia of the trunk (HP:0008936)1.90551458
118Neoplasm of the peripheral nervous system (HP:0100007)1.90423249
119Pancreatic fibrosis (HP:0100732)1.90377425
120Excessive salivation (HP:0003781)1.90097128
121Drooling (HP:0002307)1.90097128
122Pendular nystagmus (HP:0012043)1.89811944
123Delayed gross motor development (HP:0002194)1.89031685
124Popliteal pterygium (HP:0009756)1.88940159
125Limb hypertonia (HP:0002509)1.86462751
126Abnormal mitochondria in muscle tissue (HP:0008316)1.86224814
127Fetal akinesia sequence (HP:0001989)1.85367884
128Absent speech (HP:0001344)1.84989602
129Choanal stenosis (HP:0000452)1.84834688
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83708263
131Abnormal number of incisors (HP:0011064)1.83598234
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83465897
133Abnormality of the lacrimal duct (HP:0011481)1.83349931
134Diastasis recti (HP:0001540)1.83241128
135Anencephaly (HP:0002323)1.82704206
136Abnormality of the labia minora (HP:0012880)1.82673846
137Retinal atrophy (HP:0001105)1.82260407
138Delusions (HP:0000746)1.81843249
139Gait ataxia (HP:0002066)1.81380416
140Slender build (HP:0001533)1.80755189
141Cortical dysplasia (HP:0002539)1.80751044
142Stenosis of the external auditory canal (HP:0000402)1.79181146
143Calcaneovalgus deformity (HP:0001848)1.78547450
144Aplasia involving bones of the extremities (HP:0009825)1.78361854
145Aplasia involving bones of the upper limbs (HP:0009823)1.78361854
146Aplasia of the phalanges of the hand (HP:0009802)1.78361854
147Sleep apnea (HP:0010535)1.76877770
148Incomplete penetrance (HP:0003829)1.76381501
149Cutaneous finger syndactyly (HP:0010554)1.73912959
150Nephrogenic diabetes insipidus (HP:0009806)1.73912668
151Abnormal hair whorl (HP:0010721)1.73452648
152Lower limb muscle weakness (HP:0007340)1.72913066
153Reticulocytopenia (HP:0001896)1.72346964
154Cerebral hemorrhage (HP:0001342)1.71743239
155Papilledema (HP:0001085)1.70800485
156Rib fusion (HP:0000902)1.69952350
157Acute necrotizing encephalopathy (HP:0006965)1.69910432
158Torticollis (HP:0000473)1.69873578
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.69383973
160Bradykinesia (HP:0002067)1.68330410
161Type 2 muscle fiber atrophy (HP:0003554)1.67396156
162Abnormality of the dental root (HP:0006486)1.67355884
163Taurodontia (HP:0000679)1.67355884
164Abnormality of permanent molar morphology (HP:0011071)1.67355884
165True hermaphroditism (HP:0010459)1.67344494
166Renal hypoplasia (HP:0000089)1.65448190
167Sclerocornea (HP:0000647)1.65199269
168Absent radius (HP:0003974)1.63457128
169Poor coordination (HP:0002370)1.62595142
170Meckel diverticulum (HP:0002245)1.62182487
171Absent forearm bone (HP:0003953)1.60188338
172Aplasia involving forearm bones (HP:0009822)1.60188338
173Hypophosphatemic rickets (HP:0004912)1.59949722
174Amniotic constriction ring (HP:0009775)1.59908421
175Abnormality of placental membranes (HP:0011409)1.59908421
176Chin dimple (HP:0010751)1.59286929
177Hip contracture (HP:0003273)1.58966009
178Absent hair (HP:0002298)1.58725050
179Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58241357
180Postaxial hand polydactyly (HP:0001162)1.58219194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.32785839
2STK38L3.19997580
3MKNK23.15443691
4CDC73.07967827
5FES2.73740402
6MAP3K122.69303453
7ZAK2.57325278
8STK382.44594018
9NEK12.37298205
10GRK52.29647320
11MAP3K42.28594942
12MINK12.28547139
13WNK32.28371888
14NTRK32.27802827
15DYRK22.27653408
16LATS22.22731443
17EPHA42.22718376
18MAPKAPK52.20839720
19MAP3K92.20092987
20TTK2.09400590
21VRK12.04859297
22MAP2K41.92557560
23PLK21.85640093
24MKNK11.81177919
25PAK61.80781088
26DYRK1A1.79654793
27MAP2K71.74279377
28WNK11.73048017
29CDK141.55888131
30SIK21.54745492
31PHKG21.54644826
32PHKG11.54644826
33VRK21.53713767
34PNCK1.53702555
35KSR21.53110241
36CDK151.52339306
37EPHA31.51882391
38RIPK11.48735647
39CDK181.46358501
40FRK1.46205269
41NTRK21.45861010
42SRPK11.42983097
43CDK11A1.42641435
44FGFR21.40251110
45TSSK61.38397430
46CDK121.38287479
47PRKD31.37888927
48FGR1.37298897
49FER1.35610517
50CAMK2A1.33489012
51TAOK11.33083795
52CDK51.31409664
53CSNK1G31.30861899
54CSNK1G21.28745416
55LMTK21.26770766
56STK241.26548107
57NTRK11.25388656
58RIPK41.17356266
59CHEK21.13614356
60TLK11.11145436
61PLK11.10802782
62GRK61.09662865
63BMPR1B1.08365924
64CASK1.08206231
65CAMK2D1.07488926
66STK391.07338006
67MAPK151.04751218
68KSR11.04661792
69PLK41.03810784
70BUB11.02078066
71INSRR1.00383231
72OXSR10.99438439
73DYRK30.99408541
74BRD40.98972615
75PKN10.98706877
76PAK30.95162662
77PRKCG0.92106967
78CAMK1G0.91771825
79MOS0.88478883
80UHMK10.86977622
81WNK40.84657884
82CSNK1G10.84216272
83NUAK10.83050260
84MAPK100.82752277
85MAPK130.82525414
86CDC42BPA0.81281060
87CAMK2B0.80960346
88SGK4940.80637830
89SGK2230.80637830
90PLK30.79218738
91BRSK20.79144036
92TAF10.78803411
93PBK0.77052744
94AURKA0.76758922
95PRKAA10.76337039
96RET0.75983470
97ADRBK10.75280281
98MAP3K130.74945311
99STK30.69785426
100PTK2B0.69374807
101ROCK20.68887923
102CAMK2G0.68037024
103CAMKK10.67660895
104NEK60.65957655
105ERBB30.65124815
106MARK30.64322267
107CAMK10.62679156
108DDR20.62219541
109LATS10.59629106
110PRKCE0.58997931
111CDK190.57903464
112SIK10.57534553
113RPS6KA40.57191779
114STK110.55761475
115ERBB40.55471099
116RPS6KA30.54829636
117ADRBK20.54336082
118ALK0.52874819
119MAP3K100.51837874
120NME10.51221757
121PRKCQ0.50189996
122TYRO30.49446186
123SGK10.48928359
124ATM0.48861460
125PRKCA0.48631019
126PRKCB0.48380561
127MAPK90.47698985
128CDK70.47342346
129SGK20.47130022
130GRK70.46500921
131OBSCN0.45193485
132PTK20.44976420
133PASK0.44750830
134PRKCZ0.44582232
135CDK10.44035857
136STK160.43583804
137MARK20.43580087
138TIE10.41600413
139ARAF0.41335634
140DMPK0.40762276
141MAP4K20.40195232
142FYN0.39339590
143PRKG10.38442752
144ACVR1B0.37659961
145CSNK1A1L0.37359182
146CSNK1E0.37049953
147TNIK0.36995403
148PRKACB0.35999194
149PRKD20.35472135
150CDK20.35334889
151RPS6KA10.35174768
152EPHB20.34942595
153CSNK1A10.34872996
154CSNK1D0.34593422
155RAF10.34534821
156CHEK10.33717571
157MAP3K20.31811836
158PRKACA0.31289740
159CAMK1D0.31101565

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.72979906
2Synaptic vesicle cycle_Homo sapiens_hsa047213.88369988
3GABAergic synapse_Homo sapiens_hsa047273.02944254
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75832715
5Morphine addiction_Homo sapiens_hsa050322.61565072
6Mismatch repair_Homo sapiens_hsa034302.56576019
7Circadian entrainment_Homo sapiens_hsa047132.48538531
8Protein export_Homo sapiens_hsa030602.37510893
9Ribosome_Homo sapiens_hsa030102.37074561
10Cholinergic synapse_Homo sapiens_hsa047252.28814118
11Cocaine addiction_Homo sapiens_hsa050302.27170386
12Glutamatergic synapse_Homo sapiens_hsa047242.25057211
13Dopaminergic synapse_Homo sapiens_hsa047282.19899865
14Collecting duct acid secretion_Homo sapiens_hsa049662.18267239
15Long-term potentiation_Homo sapiens_hsa047202.14600105
16Insulin secretion_Homo sapiens_hsa049112.10921993
17Amphetamine addiction_Homo sapiens_hsa050312.09201750
18Basal transcription factors_Homo sapiens_hsa030222.04235165
19Salivary secretion_Homo sapiens_hsa049701.95325694
20RNA degradation_Homo sapiens_hsa030181.95113943
21Homologous recombination_Homo sapiens_hsa034401.92149590
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88237218
23RNA polymerase_Homo sapiens_hsa030201.87382905
24Serotonergic synapse_Homo sapiens_hsa047261.85605913
25Olfactory transduction_Homo sapiens_hsa047401.83787799
26Renin secretion_Homo sapiens_hsa049241.82789317
27Spliceosome_Homo sapiens_hsa030401.77280142
28Taste transduction_Homo sapiens_hsa047421.74451443
29DNA replication_Homo sapiens_hsa030301.56572689
30Long-term depression_Homo sapiens_hsa047301.51920019
31RNA transport_Homo sapiens_hsa030131.50000196
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49466359
33Cardiac muscle contraction_Homo sapiens_hsa042601.48762928
34Oxytocin signaling pathway_Homo sapiens_hsa049211.48220736
35* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47729622
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45249266
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44564117
38Cell cycle_Homo sapiens_hsa041101.44504851
39Phototransduction_Homo sapiens_hsa047441.41409171
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37704312
41Gastric acid secretion_Homo sapiens_hsa049711.34720884
42Selenocompound metabolism_Homo sapiens_hsa004501.29985576
43Proteasome_Homo sapiens_hsa030501.23191706
44Oxidative phosphorylation_Homo sapiens_hsa001901.22902405
45* Calcium signaling pathway_Homo sapiens_hsa040201.21231732
46Parkinsons disease_Homo sapiens_hsa050121.19953126
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.16242757
48Vibrio cholerae infection_Homo sapiens_hsa051101.15145173
49GnRH signaling pathway_Homo sapiens_hsa049121.13735832
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13309900
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13159434
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11752191
53Hedgehog signaling pathway_Homo sapiens_hsa043401.10742806
54Estrogen signaling pathway_Homo sapiens_hsa049151.08089751
55Gap junction_Homo sapiens_hsa045401.07445271
56Dilated cardiomyopathy_Homo sapiens_hsa054141.07274862
57Inositol phosphate metabolism_Homo sapiens_hsa005621.07246732
58Folate biosynthesis_Homo sapiens_hsa007901.03986226
59Alzheimers disease_Homo sapiens_hsa050101.02986960
60Nucleotide excision repair_Homo sapiens_hsa034201.02604124
61Basal cell carcinoma_Homo sapiens_hsa052171.01628163
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01564262
63Fanconi anemia pathway_Homo sapiens_hsa034601.00477846
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97235107
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.96683956
66Axon guidance_Homo sapiens_hsa043600.96312485
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95978555
68Vitamin B6 metabolism_Homo sapiens_hsa007500.94947787
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94750736
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94582888
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92089422
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91553766
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91091591
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.87207806
75mRNA surveillance pathway_Homo sapiens_hsa030150.84740886
76Base excision repair_Homo sapiens_hsa034100.83723027
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82811128
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82119026
79Circadian rhythm_Homo sapiens_hsa047100.81024425
80Oocyte meiosis_Homo sapiens_hsa041140.79110164
81Bile secretion_Homo sapiens_hsa049760.78771898
82Melanogenesis_Homo sapiens_hsa049160.78739625
83Thyroid hormone synthesis_Homo sapiens_hsa049180.76809565
84cAMP signaling pathway_Homo sapiens_hsa040240.75707702
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75112792
86Hippo signaling pathway_Homo sapiens_hsa043900.75064469
87Tight junction_Homo sapiens_hsa045300.74687729
88Type II diabetes mellitus_Homo sapiens_hsa049300.74298618
89Purine metabolism_Homo sapiens_hsa002300.73708404
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73584536
91Steroid biosynthesis_Homo sapiens_hsa001000.73225946
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73049640
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71900161
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70506603
95Huntingtons disease_Homo sapiens_hsa050160.70504078
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70275595
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68607583
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66682817
99Retinol metabolism_Homo sapiens_hsa008300.63703139
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63353321
101Renin-angiotensin system_Homo sapiens_hsa046140.61221460
102One carbon pool by folate_Homo sapiens_hsa006700.60658112
103Pancreatic secretion_Homo sapiens_hsa049720.59952966
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58923882
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57909647
106Glucagon signaling pathway_Homo sapiens_hsa049220.56673700
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56642945
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55731572
109Vitamin digestion and absorption_Homo sapiens_hsa049770.54178240
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52156358
111Caffeine metabolism_Homo sapiens_hsa002320.52138743
112African trypanosomiasis_Homo sapiens_hsa051430.51815930
113Starch and sucrose metabolism_Homo sapiens_hsa005000.51519873
114Pyruvate metabolism_Homo sapiens_hsa006200.50249993
115Rheumatoid arthritis_Homo sapiens_hsa053230.49564096
116Nitrogen metabolism_Homo sapiens_hsa009100.48553904
117Protein digestion and absorption_Homo sapiens_hsa049740.48230412
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47414987
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47358093
120Alcoholism_Homo sapiens_hsa050340.45865014
121Dorso-ventral axis formation_Homo sapiens_hsa043200.45406578
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45378378
123Chemical carcinogenesis_Homo sapiens_hsa052040.44530724
124TGF-beta signaling pathway_Homo sapiens_hsa043500.42924330
125Biosynthesis of amino acids_Homo sapiens_hsa012300.42731083
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.42200790
127Ovarian steroidogenesis_Homo sapiens_hsa049130.42173985
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38879701
129Ras signaling pathway_Homo sapiens_hsa040140.36101422
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35659601
131MAPK signaling pathway_Homo sapiens_hsa040100.34214180
132Phenylalanine metabolism_Homo sapiens_hsa003600.34108289
133Pyrimidine metabolism_Homo sapiens_hsa002400.33265537
134Metabolic pathways_Homo sapiens_hsa011000.30820140
135Linoleic acid metabolism_Homo sapiens_hsa005910.30098650
136Fatty acid biosynthesis_Homo sapiens_hsa000610.29611260
137Pentose phosphate pathway_Homo sapiens_hsa000300.29504809
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27679092
139mTOR signaling pathway_Homo sapiens_hsa041500.26073540
140Rap1 signaling pathway_Homo sapiens_hsa040150.24652261
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23897241
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.23684315
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.23555301
144Butanoate metabolism_Homo sapiens_hsa006500.22722104
145ErbB signaling pathway_Homo sapiens_hsa040120.22322333
146Tyrosine metabolism_Homo sapiens_hsa003500.22054560
147Wnt signaling pathway_Homo sapiens_hsa043100.21710704
148Renal cell carcinoma_Homo sapiens_hsa052110.19854887
149Glioma_Homo sapiens_hsa052140.17899342
150Choline metabolism in cancer_Homo sapiens_hsa052310.16904058
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16368890
152Galactose metabolism_Homo sapiens_hsa000520.15361357
153Endocytosis_Homo sapiens_hsa041440.15209221
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.14786022

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