TADA2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.00173741
2nucleobase biosynthetic process (GO:0046112)4.63067656
3mitotic metaphase plate congression (GO:0007080)4.62478541
4response to pheromone (GO:0019236)4.56885016
5purine nucleobase biosynthetic process (GO:0009113)4.47227377
6DNA replication initiation (GO:0006270)4.42821105
7DNA strand elongation involved in DNA replication (GO:0006271)4.28581899
8DNA strand elongation (GO:0022616)4.16592920
9protein localization to kinetochore (GO:0034501)4.05057590
10IMP biosynthetic process (GO:0006188)3.98808117
11CENP-A containing nucleosome assembly (GO:0034080)3.94822064
12metaphase plate congression (GO:0051310)3.94813859
13DNA replication checkpoint (GO:0000076)3.92890573
14cullin deneddylation (GO:0010388)3.91950758
15chromatin remodeling at centromere (GO:0031055)3.91489917
16DNA unwinding involved in DNA replication (GO:0006268)3.89549402
17ribosome biogenesis (GO:0042254)3.89241933
18telomere maintenance via semi-conservative replication (GO:0032201)3.87144060
19fucose catabolic process (GO:0019317)3.84732848
20L-fucose metabolic process (GO:0042354)3.84732848
21L-fucose catabolic process (GO:0042355)3.84732848
22nuclear pore organization (GO:0006999)3.80885863
23formation of translation preinitiation complex (GO:0001731)3.77300550
24maturation of SSU-rRNA (GO:0030490)3.75886164
25spliceosomal snRNP assembly (GO:0000387)3.71342218
26protein deneddylation (GO:0000338)3.70406299
27mitotic nuclear envelope disassembly (GO:0007077)3.61476229
28replication fork processing (GO:0031297)3.58719805
29ribosome assembly (GO:0042255)3.58017311
30DNA deamination (GO:0045006)3.57249692
31DNA replication-independent nucleosome organization (GO:0034724)3.50897430
32DNA replication-independent nucleosome assembly (GO:0006336)3.50897430
33nuclear pore complex assembly (GO:0051292)3.48566361
34termination of RNA polymerase III transcription (GO:0006386)3.48407792
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.48407792
36mitotic sister chromatid segregation (GO:0000070)3.46871796
37telomere maintenance via telomere lengthening (GO:0010833)3.46427797
38telomere maintenance via recombination (GO:0000722)3.46409932
39piRNA metabolic process (GO:0034587)3.44223425
40kinetochore organization (GO:0051383)3.44175877
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41050877
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.41050877
43maturation of 5.8S rRNA (GO:0000460)3.40702165
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40336728
45rRNA modification (GO:0000154)3.39415246
46respiratory chain complex IV assembly (GO:0008535)3.38237854
47establishment of chromosome localization (GO:0051303)3.38052219
48mitotic recombination (GO:0006312)3.38008154
49IMP metabolic process (GO:0046040)3.37491021
50DNA replication-dependent nucleosome assembly (GO:0006335)3.37435611
51DNA replication-dependent nucleosome organization (GO:0034723)3.37435611
52attachment of spindle microtubules to kinetochore (GO:0008608)3.36535882
53histone exchange (GO:0043486)3.34340826
54protein K6-linked ubiquitination (GO:0085020)3.34287976
55transcription-coupled nucleotide-excision repair (GO:0006283)3.34252702
56nuclear envelope disassembly (GO:0051081)3.33817998
57membrane disassembly (GO:0030397)3.33817998
58ribonucleoprotein complex biogenesis (GO:0022613)3.30566879
59protein localization to chromosome, centromeric region (GO:0071459)3.29250855
60rRNA processing (GO:0006364)3.28355032
61kinetochore assembly (GO:0051382)3.27961834
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26905192
63centriole replication (GO:0007099)3.26772247
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.26400933
65pseudouridine synthesis (GO:0001522)3.25585998
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.25321355
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24716286
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.24716286
69NADH dehydrogenase complex assembly (GO:0010257)3.24716286
70protein complex biogenesis (GO:0070271)3.22869661
71viral mRNA export from host cell nucleus (GO:0046784)3.21696872
727-methylguanosine mRNA capping (GO:0006370)3.21578011
73cellular ketone body metabolic process (GO:0046950)3.20897731
74spliceosomal complex assembly (GO:0000245)3.18929701
75RNA capping (GO:0036260)3.18913196
767-methylguanosine RNA capping (GO:0009452)3.18913196
77recombinational repair (GO:0000725)3.18721239
78rRNA metabolic process (GO:0016072)3.16802599
79regulation of cilium movement (GO:0003352)3.16315923
80transcription elongation from RNA polymerase I promoter (GO:0006362)3.15365263
81proteasome assembly (GO:0043248)3.14535803
82double-strand break repair via homologous recombination (GO:0000724)3.13917864
83spindle checkpoint (GO:0031577)3.13696821
84regulation of centriole replication (GO:0046599)3.13418801
85mitochondrial respiratory chain complex assembly (GO:0033108)3.13095383
86establishment of integrated proviral latency (GO:0075713)3.11185800
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11114074
88regulation of centrosome cycle (GO:0046605)3.10419075
89water-soluble vitamin biosynthetic process (GO:0042364)3.09394603
90kidney morphogenesis (GO:0060993)3.09092930
91protein-cofactor linkage (GO:0018065)3.08938348
92DNA double-strand break processing (GO:0000729)3.07567948
93negative regulation of DNA-dependent DNA replication (GO:2000104)3.07357219
94regulation of spindle organization (GO:0090224)3.06347099
95sister chromatid segregation (GO:0000819)3.05191953
96histone arginine methylation (GO:0034969)3.03483903
97negative regulation of chromosome segregation (GO:0051985)3.03440607
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03145469
99histone H2A acetylation (GO:0043968)3.02762935
100termination of RNA polymerase I transcription (GO:0006363)3.02539002
101transcription from RNA polymerase I promoter (GO:0006360)3.01671694
102ribosomal large subunit biogenesis (GO:0042273)3.01169648
103negative regulation of mitotic sister chromatid separation (GO:2000816)3.00495880
104negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00495880
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00495880
106negative regulation of sister chromatid segregation (GO:0033046)3.00495880
107mitotic spindle checkpoint (GO:0071174)3.00374920
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99139328
109mismatch repair (GO:0006298)2.98170615
110DNA methylation involved in gamete generation (GO:0043046)2.97944613
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97654705
112ketone body metabolic process (GO:1902224)2.95977510
113mitotic spindle assembly checkpoint (GO:0007094)2.95730299
114protein polyglutamylation (GO:0018095)2.95054852
115spindle assembly checkpoint (GO:0071173)2.94844850
116nonmotile primary cilium assembly (GO:0035058)2.94684308
117deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92771002
118kynurenine metabolic process (GO:0070189)2.92325494
119regulation of double-strand break repair via homologous recombination (GO:0010569)2.92034108
120reciprocal DNA recombination (GO:0035825)2.91657283
121reciprocal meiotic recombination (GO:0007131)2.91657283
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91051790
123regulation of chromosome segregation (GO:0051983)2.90449876
124folic acid-containing compound biosynthetic process (GO:0009396)2.90036217
125regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.89753173
126rRNA catabolic process (GO:0016075)2.88562689
127mitotic chromosome condensation (GO:0007076)2.88276637
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87465910
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87186365
130RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87186365
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86882427
132platelet dense granule organization (GO:0060155)2.86633104
133meiotic chromosome segregation (GO:0045132)2.86330153
134positive regulation of chromosome segregation (GO:0051984)2.86316500
135regulation of gene silencing by RNA (GO:0060966)2.86048064
136regulation of posttranscriptional gene silencing (GO:0060147)2.86048064
137regulation of gene silencing by miRNA (GO:0060964)2.86048064
138G1/S transition of mitotic cell cycle (GO:0000082)2.85996565
139indolalkylamine metabolic process (GO:0006586)2.85912830
140cytochrome complex assembly (GO:0017004)2.83576603
141epithelial cilium movement (GO:0003351)2.81921953
142regulation of meiosis I (GO:0060631)2.80948685
143synapsis (GO:0007129)2.79728906
144retinal cone cell development (GO:0046549)2.79105406
145axoneme assembly (GO:0035082)2.78411263
146male meiosis I (GO:0007141)2.72192875
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70410028
148male meiosis (GO:0007140)2.70358544
149energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69630489
150ATP synthesis coupled proton transport (GO:0015986)2.69630489
151mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69194701
152RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66237030
153tryptophan catabolic process (GO:0006569)2.66064001
154indole-containing compound catabolic process (GO:0042436)2.66064001
155indolalkylamine catabolic process (GO:0046218)2.66064001
156resolution of meiotic recombination intermediates (GO:0000712)2.65946506
157rRNA methylation (GO:0031167)2.62090314
158protein neddylation (GO:0045116)2.59078762
159regulation of DNA endoreduplication (GO:0032875)2.58812305
160negative regulation of telomere maintenance (GO:0032205)2.56547931
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.56437115
162protein K11-linked deubiquitination (GO:0035871)2.54377654
163sperm motility (GO:0030317)2.51868865
164ubiquinone biosynthetic process (GO:0006744)2.50905172
165multicellular organism reproduction (GO:0032504)2.47751500
166mannosylation (GO:0097502)2.46219027
167translesion synthesis (GO:0019985)2.46083078
168cilium organization (GO:0044782)2.44544819
169regulation of hexokinase activity (GO:1903299)2.44102304
170regulation of glucokinase activity (GO:0033131)2.44102304
171somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43807692
172isotype switching (GO:0045190)2.43807692
173somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43807692
174proline transport (GO:0015824)2.40897085
175mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.40858516
176tRNA processing (GO:0008033)2.39661115
177positive regulation of histone H3-K4 methylation (GO:0051571)2.37821169
178single strand break repair (GO:0000012)2.37398719
179postreplication repair (GO:0006301)2.35751560
180DNA-dependent DNA replication (GO:0006261)2.35325120
181cilium assembly (GO:0042384)2.35316948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.20605998
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49794110
3ZNF274_21170338_ChIP-Seq_K562_Hela3.73360878
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71870593
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64610660
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.57789404
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.34813695
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17415886
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13867710
10EZH2_22144423_ChIP-Seq_EOC_Human3.06614562
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.04732824
12MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04237102
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03063057
14* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96561468
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94127909
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93736350
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.90915963
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82885702
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74183761
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72967962
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70933922
22VDR_22108803_ChIP-Seq_LS180_Human2.69724051
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67680870
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42921647
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42793045
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38883168
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35996835
28GBX2_23144817_ChIP-Seq_PC3_Human2.35087068
29XRN2_22483619_ChIP-Seq_HELA_Human2.33862467
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33694681
31AR_21909140_ChIP-Seq_LNCAP_Human2.22290646
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21267990
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19399004
34IGF1R_20145208_ChIP-Seq_DFB_Human2.14301853
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13702460
36MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09215679
37E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09182674
38VDR_23849224_ChIP-Seq_CD4+_Human2.08136174
39ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07966746
40POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05194387
41FLI1_27457419_Chip-Seq_LIVER_Mouse2.04942215
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98627429
43* DCP1A_22483619_ChIP-Seq_HELA_Human1.97383140
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96897298
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.92197780
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91296079
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90830852
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90086525
49TTF2_22483619_ChIP-Seq_HELA_Human1.85134067
50FOXP3_21729870_ChIP-Seq_TREG_Human1.84252558
51GABP_19822575_ChIP-Seq_HepG2_Human1.82720936
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80073915
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.78712472
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77898321
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.76182689
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75201161
57P300_19829295_ChIP-Seq_ESCs_Human1.74061734
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73413318
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71208555
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70236091
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.69720122
62TAF15_26573619_Chip-Seq_HEK293_Human1.65645139
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59894005
64ELK1_19687146_ChIP-ChIP_HELA_Human1.59155169
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56587117
66CIITA_25753668_ChIP-Seq_RAJI_Human1.52985406
67TP53_22573176_ChIP-Seq_HFKS_Human1.52892198
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51845501
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50386878
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49553447
71ER_23166858_ChIP-Seq_MCF-7_Human1.48901682
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.48853711
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48139078
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47897595
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46446352
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.45650008
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45616612
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43448539
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41516728
80STAT3_23295773_ChIP-Seq_U87_Human1.41212267
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39019134
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38387122
83BCAT_22108803_ChIP-Seq_LS180_Human1.34471227
84TCF4_23295773_ChIP-Seq_U87_Human1.33786309
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33733005
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31779587
87CBP_20019798_ChIP-Seq_JUKART_Human1.31779587
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31534077
89KDM5A_27292631_Chip-Seq_BREAST_Human1.30978747
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30641723
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29864493
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29577132
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28768343
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27869790
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27009786
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26795169
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26493432
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25640812
99SOX2_19829295_ChIP-Seq_ESCs_Human1.25079187
100NANOG_19829295_ChIP-Seq_ESCs_Human1.25079187
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24799223
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23830300
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23830300
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23830300
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.23671403
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23671403
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20575015
108REST_21632747_ChIP-Seq_MESCs_Mouse1.17575457
109* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16147501
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15954496
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15100968
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14860085
113AR_25329375_ChIP-Seq_VCAP_Human1.14730989
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14636581
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14636581
116SMAD4_21799915_ChIP-Seq_A2780_Human1.14042228
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.12709056
118NCOR_22424771_ChIP-Seq_293T_Human1.12631728
119MYC_18940864_ChIP-ChIP_HL60_Human1.12353745
120TCF4_22108803_ChIP-Seq_LS180_Human1.11136739
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11111380
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10649467
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.09709599
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09623072
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09255879
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09108847
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08959212
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08889648
129EGR1_19374776_ChIP-ChIP_THP-1_Human1.08672333
130TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08012411
131SOX2_16153702_ChIP-ChIP_HESCs_Human1.07470186
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07300118
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06690883
134SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06527263
135BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05047987
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.04769515
137* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04364455
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.03458823
139HOXB7_26014856_ChIP-Seq_BT474_Human1.03194524
140NFE2_27457419_Chip-Seq_LIVER_Mouse1.02992026
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.02369124
142E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01902604
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01813492
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01719904
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.01468899
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00544628
147RUNX2_22187159_ChIP-Seq_PCA_Human0.99485293
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99031122
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.98867108
150CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98600382
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97530289
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96754622
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96619869
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96233126
155EWS_26573619_Chip-Seq_HEK293_Human0.95544508
156NANOG_16153702_ChIP-ChIP_HESCs_Human0.95480188
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95048497
158* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94903915
159AR_20517297_ChIP-Seq_VCAP_Human0.94884588
160IRF1_19129219_ChIP-ChIP_H3396_Human0.94854636
161SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93260820
162AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93045812
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.91985544
164SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90562208
165SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88279830
166ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88193556
167CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87429113
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87396786
169FUS_26573619_Chip-Seq_HEK293_Human0.85984684
170NOTCH1_21737748_ChIP-Seq_TLL_Human0.84588392
171SOX17_20123909_ChIP-Seq_XEN_Mouse0.83600367
172SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82332353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.42959342
2MP0010094_abnormal_chromosome_stability4.09068408
3MP0003111_abnormal_nucleus_morphology3.97201700
4MP0004957_abnormal_blastocyst_morpholog3.81131373
5MP0003077_abnormal_cell_cycle3.44991091
6MP0008057_abnormal_DNA_replication3.39977830
7MP0008058_abnormal_DNA_repair3.18105652
8MP0003136_yellow_coat_color2.99867074
9MP0003123_paternal_imprinting2.88273394
10MP0006292_abnormal_olfactory_placode2.68332695
11MP0008932_abnormal_embryonic_tissue2.67351363
12MP0008877_abnormal_DNA_methylation2.45391122
13MP0008007_abnormal_cellular_replicative2.42326128
14MP0003718_maternal_effect2.36351774
15MP0003646_muscle_fatigue2.27766097
16MP0000569_abnormal_digit_pigmentation2.22906601
17MP0005551_abnormal_eye_electrophysiolog2.17442921
18MP0000566_synostosis2.16262874
19MP0001730_embryonic_growth_arrest2.14093668
20MP0003121_genomic_imprinting2.10214713
21MP0010030_abnormal_orbit_morphology2.09561061
22MP0008872_abnormal_physiological_respon2.07171131
23MP0001968_abnormal_touch/_nociception2.02763603
24MP0002837_dystrophic_cardiac_calcinosis2.02172556
25MP0009046_muscle_twitch1.99346887
26MP0004133_heterotaxia1.98587013
27MP0005646_abnormal_pituitary_gland1.98477730
28MP0005645_abnormal_hypothalamus_physiol1.96422319
29MP0003890_abnormal_embryonic-extraembry1.96138939
30MP0004142_abnormal_muscle_tone1.91583276
31MP0000350_abnormal_cell_proliferation1.90701891
32MP0001986_abnormal_taste_sensitivity1.89389862
33MP0000372_irregular_coat_pigmentation1.85038209
34MP0005174_abnormal_tail_pigmentation1.83154311
35MP0002736_abnormal_nociception_after1.81079368
36MP0003786_premature_aging1.75591942
37MP0002163_abnormal_gland_morphology1.75257610
38MP0009745_abnormal_behavioral_response1.72760276
39MP0002272_abnormal_nervous_system1.71641387
40MP0003195_calcinosis1.71628443
41MP0005380_embryogenesis_phenotype1.65539102
42MP0001672_abnormal_embryogenesis/_devel1.65539102
43MP0002876_abnormal_thyroid_physiology1.65152225
44MP0002653_abnormal_ependyma_morphology1.62029988
45MP0003787_abnormal_imprinting1.60298970
46MP0002085_abnormal_embryonic_tissue1.58078348
47MP0000427_abnormal_hair_cycle1.57053726
48MP0002735_abnormal_chemical_nociception1.56421430
49MP0005410_abnormal_fertilization1.54458785
50MP0003806_abnormal_nucleotide_metabolis1.52665918
51MP0001697_abnormal_embryo_size1.52223168
52MP0003119_abnormal_digestive_system1.51963977
53MP0005253_abnormal_eye_physiology1.50987898
54MP0005379_endocrine/exocrine_gland_phen1.47840669
55MP0002084_abnormal_developmental_patter1.45431990
56MP0004885_abnormal_endolymph1.45257968
57MP0003984_embryonic_growth_retardation1.40791579
58MP0001984_abnormal_olfaction1.39377197
59MP0002088_abnormal_embryonic_growth/wei1.35828590
60MP0005084_abnormal_gallbladder_morpholo1.35656144
61MP0003937_abnormal_limbs/digits/tail_de1.34952771
62MP0001293_anophthalmia1.32373098
63MP0002095_abnormal_skin_pigmentation1.30463629
64MP0001529_abnormal_vocalization1.28557973
65MP0002080_prenatal_lethality1.27719044
66MP0000049_abnormal_middle_ear1.27650504
67MP0003315_abnormal_perineum_morphology1.24870809
68MP0003938_abnormal_ear_development1.22887928
69MP0002210_abnormal_sex_determination1.21870781
70MP0002064_seizures1.21501528
71MP0003880_abnormal_central_pattern1.17407265
72MP0002938_white_spotting1.17291015
73MP0004043_abnormal_pH_regulation1.17252834
74MP0005171_absent_coat_pigmentation1.17241482
75MP0006276_abnormal_autonomic_nervous1.16614688
76MP0002733_abnormal_thermal_nociception1.15553807
77MP0005075_abnormal_melanosome_morpholog1.15512309
78MP0001486_abnormal_startle_reflex1.14841727
79MP0003941_abnormal_skin_development1.13933395
80MP0002160_abnormal_reproductive_system1.13431378
81MP0002086_abnormal_extraembryonic_tissu1.12055886
82MP0000015_abnormal_ear_pigmentation1.12036500
83MP0001501_abnormal_sleep_pattern1.11223610
84MP0002067_abnormal_sensory_capabilities1.10662249
85MP0001970_abnormal_pain_threshold1.10121694
86MP0002572_abnormal_emotion/affect_behav1.08917378
87MP0001873_stomach_inflammation1.08222843
88MP0004145_abnormal_muscle_electrophysio1.07545593
89MP0004197_abnormal_fetal_growth/weight/1.07004001
90MP0001145_abnormal_male_reproductive1.06596075
91MP0003861_abnormal_nervous_system1.06528553
92MP0004233_abnormal_muscle_weight1.05347482
93MP0008789_abnormal_olfactory_epithelium1.04777159
94MP0002396_abnormal_hematopoietic_system1.04609929
95MP0002557_abnormal_social/conspecific_i1.04030219
96MP0004742_abnormal_vestibular_system1.03897691
97MP0002751_abnormal_autonomic_nervous1.03526151
98MP0003755_abnormal_palate_morphology1.02262586
99MP0002102_abnormal_ear_morphology1.00385178
100MP0000313_abnormal_cell_death0.99684043
101MP0001188_hyperpigmentation0.99667965
102MP0000537_abnormal_urethra_morphology0.99028951
103MP0003635_abnormal_synaptic_transmissio0.97594766
104MP0010386_abnormal_urinary_bladder0.95796329
105MP0005377_hearing/vestibular/ear_phenot0.94907028
106MP0003878_abnormal_ear_physiology0.94907028
107MP0002638_abnormal_pupillary_reflex0.94680410
108MP0000653_abnormal_sex_gland0.94205939
109MP0001929_abnormal_gametogenesis0.93435848
110MP0009672_abnormal_birth_weight0.92971942
111MP0001286_abnormal_eye_development0.92595538
112MP0006072_abnormal_retinal_apoptosis0.92283292
113MP0008875_abnormal_xenobiotic_pharmacok0.91047531
114MP0002063_abnormal_learning/memory/cond0.88495678
115MP0002928_abnormal_bile_duct0.87055698
116MP0001485_abnormal_pinna_reflex0.86855736
117MP0003122_maternal_imprinting0.86639021
118MP0010307_abnormal_tumor_latency0.86111594
119MP0005195_abnormal_posterior_eye0.85737312
120MP0005394_taste/olfaction_phenotype0.85710527
121MP0005499_abnormal_olfactory_system0.85710527
122MP0002734_abnormal_mechanical_nocicepti0.85612043
123MP0001905_abnormal_dopamine_level0.85140570
124MP0006036_abnormal_mitochondrial_physio0.83416615
125MP0005386_behavior/neurological_phenoty0.83408868
126MP0004924_abnormal_behavior0.83408868
127MP0002111_abnormal_tail_morphology0.83186277
128MP0005423_abnormal_somatic_nervous0.81812917
129MP0003950_abnormal_plasma_membrane0.80585073
130MP0008775_abnormal_heart_ventricle0.80092412
131MP0003567_abnormal_fetal_cardiomyocyte0.80088760
132MP0005389_reproductive_system_phenotype0.77361211
133MP0001324_abnormal_eye_pigmentation0.77283038
134MP0002229_neurodegeneration0.77204702
135MP0006035_abnormal_mitochondrial_morpho0.76871899
136MP0009703_decreased_birth_body0.76862300
137MP0000516_abnormal_urinary_system0.75844393
138MP0005367_renal/urinary_system_phenotyp0.75844393
139MP0010352_gastrointestinal_tract_polyps0.75061931
140MP0002693_abnormal_pancreas_physiology0.74814892
141MP0002234_abnormal_pharynx_morphology0.74030077
142MP0008260_abnormal_autophagy0.73867704
143MP0000631_abnormal_neuroendocrine_gland0.73217713
144MP0001119_abnormal_female_reproductive0.72692124
145MP0004147_increased_porphyrin_level0.72485834
146MP0000490_abnormal_crypts_of0.71012401
147MP0003115_abnormal_respiratory_system0.70617899
148MP0003936_abnormal_reproductive_system0.69636606
149MP0000428_abnormal_craniofacial_morphol0.69458245
150MP0002249_abnormal_larynx_morphology0.69333645
151MP0002116_abnormal_craniofacial_bone0.69156158
152MP0002127_abnormal_cardiovascular_syste0.69143180
153MP0000432_abnormal_head_morphology0.67946508
154MP0002114_abnormal_axial_skeleton0.67172329
155MP0003698_abnormal_male_reproductive0.65221929
156MP0000778_abnormal_nervous_system0.64682453
157MP0003935_abnormal_craniofacial_develop0.63107510
158MP0002233_abnormal_nose_morphology0.62804691
159MP0005384_cellular_phenotype0.61163062
160MP0001919_abnormal_reproductive_system0.59383106
161MP0000026_abnormal_inner_ear0.59295761
162MP0002019_abnormal_tumor_incidence0.59073881
163MP0003283_abnormal_digestive_organ0.58955747

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.88347246
2Breast hypoplasia (HP:0003187)3.99030040
3Molar tooth sign on MRI (HP:0002419)3.86068943
4Abnormality of midbrain morphology (HP:0002418)3.86068943
5Cerebral hypomyelination (HP:0006808)3.77367176
6Abnormality of the labia minora (HP:0012880)3.75568167
7Nephronophthisis (HP:0000090)3.40007742
8Chromsome breakage (HP:0040012)3.23939213
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20580290
10Type II lissencephaly (HP:0007260)3.19946037
11Selective tooth agenesis (HP:0001592)3.19174449
12Ependymoma (HP:0002888)3.17562160
13Congenital stationary night blindness (HP:0007642)3.16752183
14Absent radius (HP:0003974)3.13130969
15Patellar aplasia (HP:0006443)3.05157365
16Medial flaring of the eyebrow (HP:0010747)3.03286548
17Abnormality of the renal cortex (HP:0011035)3.01224302
18Absent forearm bone (HP:0003953)2.98805106
19Aplasia involving forearm bones (HP:0009822)2.98805106
20Rough bone trabeculation (HP:0100670)2.96604578
21Abnormality of the renal medulla (HP:0100957)2.88708800
22Attenuation of retinal blood vessels (HP:0007843)2.88502949
23Meckel diverticulum (HP:0002245)2.88039164
24Aplasia/Hypoplasia of the patella (HP:0006498)2.86376980
25Abnormality of the ileum (HP:0001549)2.84289055
26Abnormality of the preputium (HP:0100587)2.81431284
27Medulloblastoma (HP:0002885)2.79766454
28Supernumerary spleens (HP:0009799)2.75043310
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.72449131
30Colon cancer (HP:0003003)2.72436812
31Oral leukoplakia (HP:0002745)2.71376262
32Abnormality of the anterior horn cell (HP:0006802)2.69474213
33Degeneration of anterior horn cells (HP:0002398)2.69474213
34Cerebellar dysplasia (HP:0007033)2.63061186
35Abnormality of chromosome stability (HP:0003220)2.60030099
36Acute necrotizing encephalopathy (HP:0006965)2.58430239
37Impulsivity (HP:0100710)2.57856254
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.57383249
393-Methylglutaconic aciduria (HP:0003535)2.56714419
40Chronic hepatic failure (HP:0100626)2.51883398
41Mitochondrial inheritance (HP:0001427)2.51101142
42Polydipsia (HP:0001959)2.50353846
43Abnormal drinking behavior (HP:0030082)2.50353846
44Premature graying of hair (HP:0002216)2.50050791
45Pendular nystagmus (HP:0012043)2.49499396
46Hyperventilation (HP:0002883)2.46177154
47Renal cortical cysts (HP:0000803)2.41739670
48Increased CSF lactate (HP:0002490)2.40846233
49Gaze-evoked nystagmus (HP:0000640)2.39800890
50Hypothermia (HP:0002045)2.39023473
51Gait imbalance (HP:0002141)2.37856687
52Progressive macrocephaly (HP:0004481)2.37774651
53Lipid accumulation in hepatocytes (HP:0006561)2.35114033
54Hypoplasia of the pons (HP:0012110)2.33461508
55Small intestinal stenosis (HP:0012848)2.33437935
56Duodenal stenosis (HP:0100867)2.33437935
57Lissencephaly (HP:0001339)2.33311482
58Nephrogenic diabetes insipidus (HP:0009806)2.31913116
59Abnormality of glycolysis (HP:0004366)2.30839380
60Increased serum pyruvate (HP:0003542)2.30839380
61Congenital primary aphakia (HP:0007707)2.30426007
62Abnormality of the pons (HP:0007361)2.29641123
63Abnormal lung lobation (HP:0002101)2.28669404
64Tubular atrophy (HP:0000092)2.27771736
65Astrocytoma (HP:0009592)2.27722456
66Abnormality of the astrocytes (HP:0100707)2.27722456
67Hepatocellular necrosis (HP:0001404)2.25699181
68Carpal bone hypoplasia (HP:0001498)2.24888995
69Triphalangeal thumb (HP:0001199)2.24058019
70Inability to walk (HP:0002540)2.23377005
71Acute encephalopathy (HP:0006846)2.22599718
72Agnosia (HP:0010524)2.22270128
73Abnormal number of incisors (HP:0011064)2.21573877
74Abnormal rod and cone electroretinograms (HP:0008323)2.21563549
75Glioma (HP:0009733)2.21536383
76Stenosis of the external auditory canal (HP:0000402)2.19797051
77Hypomagnesemia (HP:0002917)2.19329952
78Sclerocornea (HP:0000647)2.15475410
79CNS hypomyelination (HP:0003429)2.14753351
80Hepatic necrosis (HP:0002605)2.14601807
81Increased hepatocellular lipid droplets (HP:0006565)2.13919818
82Cystic liver disease (HP:0006706)2.13117737
83Abnormal mitochondria in muscle tissue (HP:0008316)2.11698693
84Absent thumb (HP:0009777)2.10638709
85Reticulocytopenia (HP:0001896)2.09818467
86Sloping forehead (HP:0000340)2.09654718
87Abnormal number of erythroid precursors (HP:0012131)2.08770233
88Abnormal trabecular bone morphology (HP:0100671)2.07805086
89Bone marrow hypocellularity (HP:0005528)2.07335099
90Horseshoe kidney (HP:0000085)2.06644032
91Decreased central vision (HP:0007663)2.05792407
92Cellular immunodeficiency (HP:0005374)2.05433557
93Duplicated collecting system (HP:0000081)2.04629075
94Abolished electroretinogram (ERG) (HP:0000550)2.04075100
95Facial cleft (HP:0002006)2.03349181
96Preaxial hand polydactyly (HP:0001177)2.03287223
97Nephroblastoma (Wilms tumor) (HP:0002667)2.01904502
98Methylmalonic aciduria (HP:0012120)2.01873516
99Esophageal atresia (HP:0002032)2.00078478
100Rhabdomyosarcoma (HP:0002859)1.99392178
101Abnormality of the duodenum (HP:0002246)1.98773997
102Methylmalonic acidemia (HP:0002912)1.97937159
103Polyuria (HP:0000103)1.96629050
104Hyperalaninemia (HP:0003348)1.96505429
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96505429
106Abnormality of alanine metabolism (HP:0010916)1.96505429
107Genital tract atresia (HP:0001827)1.95708155
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95250534
109Pancreatic fibrosis (HP:0100732)1.95052412
110Large for gestational age (HP:0001520)1.93858251
111Breast aplasia (HP:0100783)1.93625532
112Fair hair (HP:0002286)1.93296646
113Atresia of the external auditory canal (HP:0000413)1.93134037
114Progressive inability to walk (HP:0002505)1.93123310
115Clubbing of toes (HP:0100760)1.92288507
116Increased serum lactate (HP:0002151)1.92093479
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.91480659
11811 pairs of ribs (HP:0000878)1.90262761
119Embryonal renal neoplasm (HP:0011794)1.89470119
120Focal motor seizures (HP:0011153)1.88637333
121Vaginal atresia (HP:0000148)1.87604672
122Furrowed tongue (HP:0000221)1.85849407
123Broad alveolar ridges (HP:0000187)1.85278045
124Aplasia/Hypoplasia of the breasts (HP:0010311)1.84186494
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.83514070
126Absent/shortened dynein arms (HP:0200106)1.83514070
127Volvulus (HP:0002580)1.83173191
128Ectopic kidney (HP:0000086)1.83058670
129Abnormality of DNA repair (HP:0003254)1.82857783
130Aplasia/Hypoplasia of the spleen (HP:0010451)1.82618414
131Neoplasm of the pancreas (HP:0002894)1.81973818
132Abnormality of the renal collecting system (HP:0004742)1.81668822
133Myelodysplasia (HP:0002863)1.81255669
134Optic disc pallor (HP:0000543)1.81154306
135Aplastic anemia (HP:0001915)1.81041000
136True hermaphroditism (HP:0010459)1.80105045
137Premature ovarian failure (HP:0008209)1.79073980
138Short middle phalanx of the 5th finger (HP:0004220)1.78931975
139Gastrointestinal atresia (HP:0002589)1.78300458
140Congenital hepatic fibrosis (HP:0002612)1.78101597
141Anencephaly (HP:0002323)1.77109181
142Neoplasm of the adrenal cortex (HP:0100641)1.76905556
143Rectal fistula (HP:0100590)1.76642296
144Rectovaginal fistula (HP:0000143)1.76642296
145Tracheoesophageal fistula (HP:0002575)1.76369213
146Oligodactyly (hands) (HP:0001180)1.75955292
147Hypoplasia of the fovea (HP:0007750)1.74670812
148Aplasia/Hypoplasia of the fovea (HP:0008060)1.74670812
149Febrile seizures (HP:0002373)1.74619183
150Asplenia (HP:0001746)1.74496862
151Type I transferrin isoform profile (HP:0003642)1.74458786
152Poor coordination (HP:0002370)1.73728113
153Astigmatism (HP:0000483)1.73027090
154Renal Fanconi syndrome (HP:0001994)1.72783129
155Pancreatic cysts (HP:0001737)1.72772652
156Septo-optic dysplasia (HP:0100842)1.72535199
157Hemiparesis (HP:0001269)1.72234534
158Short thumb (HP:0009778)1.71520869
159Rib fusion (HP:0000902)1.70283570
160Abnormality of macular pigmentation (HP:0008002)1.70111572
161Abnormality of chromosome segregation (HP:0002916)1.69946342
162Male pseudohermaphroditism (HP:0000037)1.69676528
163Broad-based gait (HP:0002136)1.69590624
164Abdominal situs inversus (HP:0003363)1.67762746
165Abnormality of abdominal situs (HP:0011620)1.67762746
166Postnatal microcephaly (HP:0005484)1.67472742
167Atrophy/Degeneration involving motor neurons (HP:0007373)1.67353869
168Duplication of thumb phalanx (HP:0009942)1.67270773
169Neoplasm of the oral cavity (HP:0100649)1.67249590
170High anterior hairline (HP:0009890)1.66568826
171Anophthalmia (HP:0000528)1.66436644
172Facial hemangioma (HP:0000329)1.65628864
173Abnormality of the fetal cardiovascular system (HP:0010948)1.64895687
174Abnormal umbilical cord blood vessels (HP:0011403)1.64895687
175Single umbilical artery (HP:0001195)1.64895687
176Adrenal hypoplasia (HP:0000835)1.64655944
177Unsteady gait (HP:0002317)1.63579240
178Abnormality of cells of the erythroid lineage (HP:0012130)1.63422503
179Missing ribs (HP:0000921)1.61406173
180Hypoplasia of the radius (HP:0002984)1.60286718
181Intestinal atresia (HP:0011100)1.59775349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.87589424
2FRK4.77216035
3CDC74.03645318
4WEE13.67891548
5TSSK63.21317336
6SRPK12.97282486
7BMPR1B2.78068813
8TTK2.68663063
9EIF2AK12.60185815
10MKNK12.48109647
11BRSK22.41180694
12MAP4K22.37438440
13NUAK12.35984634
14PLK32.31212160
15PNCK2.13850390
16NEK12.11485200
17WNK42.10033038
18AKT32.09426273
19WNK32.09382484
20PLK12.08391042
21BRSK12.05809053
22CCNB11.91223701
23GRK11.85812445
24MKNK21.78815961
25PASK1.78796184
26PLK41.77704994
27TAOK31.77599987
28NEK21.74796544
29CHEK21.72002494
30VRK11.61555299
31STK391.61494482
32EIF2AK31.61468147
33CDK81.59142430
34TRIM281.57823461
35CDK71.56090103
36STK161.55177575
37INSRR1.53564766
38OXSR11.53514846
39ATR1.52411426
40AURKA1.48565930
41MST41.47693601
42CAMKK21.47547980
43TXK1.36219500
44AURKB1.36174137
45PINK11.33587023
46CHEK11.25853175
47EPHA21.24660560
48ZAK1.21357803
49NEK61.16621771
50CASK1.14530890
51BRD41.13841009
52BRAF1.10935825
53STK38L1.03366159
54MELK0.99560005
55PLK20.97633361
56NME10.95759344
57DAPK20.95177568
58BCR0.94658556
59TESK20.92117732
60PAK30.91465245
61TLK10.91244738
62CDK20.89684056
63ADRBK10.88509951
64ATM0.87920049
65DYRK30.87566307
66DYRK20.86426996
67CAMK1G0.83502033
68LATS20.81892620
69NLK0.80945704
70CDK40.80260761
71RPS6KB20.80241254
72PRPF4B0.80073412
73CDK10.78551551
74PRKCI0.76549870
75MAP2K60.76348044
76VRK20.75102466
77PHKG20.74816850
78PHKG10.74816850
79KSR10.74567643
80CSNK1G20.73804061
81ERBB30.73016152
82CSNK2A20.72794843
83MAP2K70.72448383
84EIF2AK20.72369596
85ACVR1B0.71971142
86NTRK30.71948807
87TNIK0.71648271
88NME20.71141898
89CDK120.70247750
90BCKDK0.69748025
91TEC0.69641522
92CSNK1G10.69201116
93MAP3K80.67385267
94CDK30.65894074
95PRKCE0.65515934
96CSNK2A10.64344088
97PTK2B0.63328436
98CSNK1E0.61439003
99DAPK10.61326823
100CAMK1D0.60871649
101PRKCQ0.60836939
102CAMK10.60417221
103TAOK20.58050297
104YES10.54806918
105PAK10.54747710
106STK30.54158786
107RPS6KA50.54085232
108RAF10.53937029
109IKBKB0.53699828
110EPHA40.52684367
111MARK30.52398984
112BMPR20.52201348
113CLK10.51695512
114ALK0.50863558
115CAMK2A0.47139821
116STK110.46928029
117TIE10.45567498
118MINK10.44661312
119UHMK10.44285892
120WNK10.43614731
121DYRK1A0.43190075
122NTRK20.42654981
123CSNK1A1L0.41988562
124MAP3K60.41693067
125MAPK130.41628869
126TNK20.41436944
127CDK180.41421388
128CSNK1A10.41047698
129FGFR10.40889716
130PRKCG0.40196604
131PRKDC0.39775231
132PKN10.38737970
133TGFBR10.38397194
134TAF10.38057159
135AKT20.37574845
136CSNK1D0.37001337
137MARK10.36982830
138CDK11A0.36878840
139CDK150.36501167
140PRKACA0.35336397
141GSK3B0.33853316
142MAPK140.33804330
143PRKCH0.33682945
144PAK40.32909262
145CDK140.30884352
146RPS6KA40.30197846
147MAP3K40.29800672
148CSNK1G30.29672949
149FGFR20.28944949
150ADRBK20.28249786
151PBK0.25252142
152PDK20.24944319

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51791728
2Mismatch repair_Homo sapiens_hsa034304.29965976
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.29957623
4RNA polymerase_Homo sapiens_hsa030204.08980170
5RNA transport_Homo sapiens_hsa030133.43288171
6Spliceosome_Homo sapiens_hsa030403.39979047
7Proteasome_Homo sapiens_hsa030503.19058074
8Homologous recombination_Homo sapiens_hsa034402.98377002
9Nucleotide excision repair_Homo sapiens_hsa034202.97091181
10Cell cycle_Homo sapiens_hsa041102.76323194
11Base excision repair_Homo sapiens_hsa034102.75971836
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68101269
13Pyrimidine metabolism_Homo sapiens_hsa002402.55743210
14Ribosome_Homo sapiens_hsa030102.48406547
15Fanconi anemia pathway_Homo sapiens_hsa034602.48207679
16Basal transcription factors_Homo sapiens_hsa030222.46868887
17One carbon pool by folate_Homo sapiens_hsa006702.43689756
18Non-homologous end-joining_Homo sapiens_hsa034502.33356634
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31418550
20RNA degradation_Homo sapiens_hsa030182.18080848
21mRNA surveillance pathway_Homo sapiens_hsa030152.09956704
22Butanoate metabolism_Homo sapiens_hsa006502.00002629
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.84680652
24Vitamin B6 metabolism_Homo sapiens_hsa007501.79512278
25Nitrogen metabolism_Homo sapiens_hsa009101.77724507
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71761568
27Purine metabolism_Homo sapiens_hsa002301.63459088
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57786622
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44669374
30Olfactory transduction_Homo sapiens_hsa047401.37365484
31Propanoate metabolism_Homo sapiens_hsa006401.37053974
32Oocyte meiosis_Homo sapiens_hsa041141.36503208
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23522704
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22992867
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19258139
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15545785
37Taste transduction_Homo sapiens_hsa047421.13830852
38p53 signaling pathway_Homo sapiens_hsa041151.11558005
39Morphine addiction_Homo sapiens_hsa050321.10227951
40Tryptophan metabolism_Homo sapiens_hsa003801.07190297
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05901078
42Epstein-Barr virus infection_Homo sapiens_hsa051691.03383316
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98318271
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96444496
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.96124240
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90257711
47Peroxisome_Homo sapiens_hsa041460.86613390
48Primary immunodeficiency_Homo sapiens_hsa053400.84496231
49Huntingtons disease_Homo sapiens_hsa050160.83584250
50Collecting duct acid secretion_Homo sapiens_hsa049660.82769573
51Insulin secretion_Homo sapiens_hsa049110.82217141
52Caffeine metabolism_Homo sapiens_hsa002320.80787294
53Basal cell carcinoma_Homo sapiens_hsa052170.80164054
54Biosynthesis of amino acids_Homo sapiens_hsa012300.79090245
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.74434810
56Hippo signaling pathway_Homo sapiens_hsa043900.71889981
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67134554
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66863296
59GABAergic synapse_Homo sapiens_hsa047270.66862371
60ABC transporters_Homo sapiens_hsa020100.66234068
61Hedgehog signaling pathway_Homo sapiens_hsa043400.65891503
62Protein export_Homo sapiens_hsa030600.64165767
63Circadian entrainment_Homo sapiens_hsa047130.61356443
64Glutamatergic synapse_Homo sapiens_hsa047240.60823300
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60200344
66TGF-beta signaling pathway_Homo sapiens_hsa043500.59050664
67Parkinsons disease_Homo sapiens_hsa050120.57063661
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56349073
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56109682
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55584611
71Oxidative phosphorylation_Homo sapiens_hsa001900.54542635
72Folate biosynthesis_Homo sapiens_hsa007900.52474049
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51585500
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49661006
75Glycerolipid metabolism_Homo sapiens_hsa005610.49637973
76Viral carcinogenesis_Homo sapiens_hsa052030.49257710
77MicroRNAs in cancer_Homo sapiens_hsa052060.48370789
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.48283282
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.46365066
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.45968371
81Salivary secretion_Homo sapiens_hsa049700.45874157
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.45775035
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45756705
84Dorso-ventral axis formation_Homo sapiens_hsa043200.45602361
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45163897
86Ovarian steroidogenesis_Homo sapiens_hsa049130.44827598
87Wnt signaling pathway_Homo sapiens_hsa043100.44728162
88Systemic lupus erythematosus_Homo sapiens_hsa053220.43923031
89Thyroid cancer_Homo sapiens_hsa052160.43112060
90HTLV-I infection_Homo sapiens_hsa051660.42678564
91Notch signaling pathway_Homo sapiens_hsa043300.42127668
92Sulfur metabolism_Homo sapiens_hsa009200.41061501
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39950654
94Dopaminergic synapse_Homo sapiens_hsa047280.38536153
95Nicotine addiction_Homo sapiens_hsa050330.38498674
96Sulfur relay system_Homo sapiens_hsa041220.37687083
97Fat digestion and absorption_Homo sapiens_hsa049750.37150600
98Alcoholism_Homo sapiens_hsa050340.36911413
99Fructose and mannose metabolism_Homo sapiens_hsa000510.36854602
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36650932
101Phototransduction_Homo sapiens_hsa047440.36193050
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35498863
103Glutathione metabolism_Homo sapiens_hsa004800.35459319
104Calcium signaling pathway_Homo sapiens_hsa040200.34617434
105N-Glycan biosynthesis_Homo sapiens_hsa005100.33866046
106Chemical carcinogenesis_Homo sapiens_hsa052040.33625916
107Metabolic pathways_Homo sapiens_hsa011000.32538764
108Fatty acid metabolism_Homo sapiens_hsa012120.30163267
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29916970
110Arachidonic acid metabolism_Homo sapiens_hsa005900.29645222
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29424039
112Regulation of autophagy_Homo sapiens_hsa041400.29338854
113Synaptic vesicle cycle_Homo sapiens_hsa047210.28960087
114Herpes simplex infection_Homo sapiens_hsa051680.28653869
115Tight junction_Homo sapiens_hsa045300.28530454
116Fatty acid biosynthesis_Homo sapiens_hsa000610.28216456
117Arginine and proline metabolism_Homo sapiens_hsa003300.25200009
118Colorectal cancer_Homo sapiens_hsa052100.25081463
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24733675
120Selenocompound metabolism_Homo sapiens_hsa004500.24380412
121Steroid biosynthesis_Homo sapiens_hsa001000.22433310
122Melanoma_Homo sapiens_hsa052180.22417858
123Circadian rhythm_Homo sapiens_hsa047100.21307160
124Bladder cancer_Homo sapiens_hsa052190.21129499
125Carbon metabolism_Homo sapiens_hsa012000.20262855
126Pathways in cancer_Homo sapiens_hsa052000.19999324
127Ether lipid metabolism_Homo sapiens_hsa005650.18560743
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18261674
129Alzheimers disease_Homo sapiens_hsa050100.16608694
130Pentose phosphate pathway_Homo sapiens_hsa000300.15901514
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15272660
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13324687
133Linoleic acid metabolism_Homo sapiens_hsa005910.12508716
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11341509
135Melanogenesis_Homo sapiens_hsa049160.11167393
136Adherens junction_Homo sapiens_hsa045200.08290548
137Long-term depression_Homo sapiens_hsa047300.08246902
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07599850
139Long-term potentiation_Homo sapiens_hsa047200.07432359
140Prostate cancer_Homo sapiens_hsa052150.06917549
141Small cell lung cancer_Homo sapiens_hsa052220.06566274
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06489535
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.05589771
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04862236
145Cardiac muscle contraction_Homo sapiens_hsa042600.04602702
146HIF-1 signaling pathway_Homo sapiens_hsa040660.04058106
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.03636545
148Galactose metabolism_Homo sapiens_hsa000520.03524481
149Serotonergic synapse_Homo sapiens_hsa047260.02938591

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