TADA2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44957422
2negative regulation of cell killing (GO:0031342)5.44957422
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.00708651
4L-phenylalanine catabolic process (GO:0006559)5.00708651
5positive regulation of gamma-delta T cell activation (GO:0046645)4.94833504
6positive regulation by symbiont of host defense response (GO:0052509)4.92648489
7modulation by symbiont of host defense response (GO:0052031)4.92648489
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.92648489
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.92648489
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.92648489
11modulation by symbiont of host immune response (GO:0052553)4.92648489
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82597038
13L-phenylalanine metabolic process (GO:0006558)4.76517290
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.76517290
15alpha-linolenic acid metabolic process (GO:0036109)4.67619290
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.42674476
17lysine metabolic process (GO:0006553)4.26088777
18lysine catabolic process (GO:0006554)4.26088777
19negative regulation of erythrocyte differentiation (GO:0045647)4.25979253
20antigen processing and presentation of endogenous antigen (GO:0019883)4.15086862
21aromatic amino acid family catabolic process (GO:0009074)4.14321741
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.13589434
23cysteine metabolic process (GO:0006534)4.10459452
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06667582
25sulfur amino acid catabolic process (GO:0000098)4.04363534
26macrophage activation involved in immune response (GO:0002281)3.98796955
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94979455
28response to peptidoglycan (GO:0032494)3.90017587
29regulation of gamma-delta T cell activation (GO:0046643)3.89615119
30urea metabolic process (GO:0019627)3.88104259
31urea cycle (GO:0000050)3.88104259
32detection of other organism (GO:0098543)3.86014075
33negative regulation of fibrinolysis (GO:0051918)3.85383278
34kynurenine metabolic process (GO:0070189)3.84446744
35complement activation, alternative pathway (GO:0006957)3.82800278
36bile acid biosynthetic process (GO:0006699)3.81652243
37leukocyte aggregation (GO:0070486)3.77367530
38dicarboxylic acid biosynthetic process (GO:0043650)3.71248643
39regulation of B cell receptor signaling pathway (GO:0050855)3.71245979
40cellular extravasation (GO:0045123)3.69733345
41homocysteine metabolic process (GO:0050667)3.69120661
42regulation of protein activation cascade (GO:2000257)3.67333691
43regulation of cholesterol homeostasis (GO:2000188)3.66462024
44neutrophil activation involved in immune response (GO:0002283)3.65264412
45detection of bacterium (GO:0016045)3.62167584
46glyoxylate metabolic process (GO:0046487)3.60772716
47regulation of interferon-beta biosynthetic process (GO:0045357)3.60752089
48regulation of gamma-delta T cell differentiation (GO:0045586)3.59547352
49cellular ketone body metabolic process (GO:0046950)3.59408646
50glutamate metabolic process (GO:0006536)3.55996727
51detection of molecule of bacterial origin (GO:0032490)3.52608434
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52095684
53regulation of complement activation (GO:0030449)3.49365153
54regulation of fatty acid beta-oxidation (GO:0031998)3.49342164
55negative regulation of lymphocyte mediated immunity (GO:0002707)3.46931054
56positive regulation of fatty acid beta-oxidation (GO:0032000)3.45385916
57protein carboxylation (GO:0018214)3.44531899
58peptidyl-glutamic acid carboxylation (GO:0017187)3.44531899
59high-density lipoprotein particle remodeling (GO:0034375)3.44508401
60aspartate family amino acid catabolic process (GO:0009068)3.43937804
61detection of external biotic stimulus (GO:0098581)3.42294102
62nitrogen cycle metabolic process (GO:0071941)3.42287691
63regulation of fibrinolysis (GO:0051917)3.41784184
64short-chain fatty acid metabolic process (GO:0046459)3.41093738
65indole-containing compound catabolic process (GO:0042436)3.37823364
66indolalkylamine catabolic process (GO:0046218)3.37823364
67tryptophan catabolic process (GO:0006569)3.37823364
68negative regulation of T cell mediated immunity (GO:0002710)3.36772514
69positive thymic T cell selection (GO:0045059)3.36242878
70regulation of triglyceride catabolic process (GO:0010896)3.34021726
71germinal center formation (GO:0002467)3.33411449
72acetyl-CoA metabolic process (GO:0006084)3.32987096
73cellular modified amino acid catabolic process (GO:0042219)3.32650125
74negative regulation of interleukin-12 production (GO:0032695)3.30909041
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.30356631
76negative regulation of cholesterol transport (GO:0032375)3.29363677
77negative regulation of sterol transport (GO:0032372)3.29363677
78amino-acid betaine metabolic process (GO:0006577)3.29020715
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.27960255
80response to host immune response (GO:0052572)3.27960255
81bile acid metabolic process (GO:0008206)3.23269388
82serine family amino acid catabolic process (GO:0009071)3.21825330
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21683131
84response to host (GO:0075136)3.21683131
85response to host defenses (GO:0052200)3.21683131
86tryptophan metabolic process (GO:0006568)3.21290932
87reverse cholesterol transport (GO:0043691)3.17252515
88negative regulation of leukocyte mediated immunity (GO:0002704)3.16044655
89acylglycerol homeostasis (GO:0055090)3.14379027
90triglyceride homeostasis (GO:0070328)3.14379027
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.14059729
92ketone body metabolic process (GO:1902224)3.12272402
93B cell receptor signaling pathway (GO:0050853)3.12191040
94tolerance induction (GO:0002507)3.09564804
952-oxoglutarate metabolic process (GO:0006103)3.09545986
96fatty acid transmembrane transport (GO:1902001)3.09052201
97alpha-amino acid catabolic process (GO:1901606)3.08875570
98positive regulation of lipid catabolic process (GO:0050996)3.07067548
99plasma lipoprotein particle clearance (GO:0034381)2.98465645
100cellular amino acid catabolic process (GO:0009063)2.97739603
101detection of biotic stimulus (GO:0009595)2.97677848
102carnitine shuttle (GO:0006853)2.97273814
103phospholipid homeostasis (GO:0055091)2.95936505
104positive T cell selection (GO:0043368)2.95504113
105regulation of T cell tolerance induction (GO:0002664)2.95002934
106neutrophil activation (GO:0042119)2.94988148
107T cell selection (GO:0045058)2.94754588
108ethanol oxidation (GO:0006069)2.94242568
109response to interleukin-15 (GO:0070672)2.94099376
110thymic T cell selection (GO:0045061)2.93876135
111tyrosine metabolic process (GO:0006570)2.93621984
112regulation of mast cell degranulation (GO:0043304)2.92718856
113macrophage activation (GO:0042116)2.91814321
114regulation of T-helper 2 cell differentiation (GO:0045628)2.90215659
115antigen processing and presentation via MHC class Ib (GO:0002475)2.89958635
116positive regulation of fatty acid oxidation (GO:0046321)2.87077565
117negative regulation of fatty acid biosynthetic process (GO:0045717)2.86882686
118regulation of leukocyte degranulation (GO:0043300)2.86477415
119drug transmembrane transport (GO:0006855)2.84051978
120positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83594404
121aromatic amino acid family metabolic process (GO:0009072)2.83412817
122response to muramyl dipeptide (GO:0032495)2.83324365
123respiratory burst (GO:0045730)2.83174818
1244-hydroxyproline metabolic process (GO:0019471)2.82906871
125coenzyme catabolic process (GO:0009109)2.82575748
126protein-lipid complex remodeling (GO:0034368)2.82380095
127macromolecular complex remodeling (GO:0034367)2.82380095
128plasma lipoprotein particle remodeling (GO:0034369)2.82380095
129drug catabolic process (GO:0042737)2.82159164
130fatty acid beta-oxidation (GO:0006635)2.82087602
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81107584
132cytolysis (GO:0019835)2.80563273
133negative regulation of toll-like receptor signaling pathway (GO:0034122)2.80071391
134production of molecular mediator involved in inflammatory response (GO:0002532)2.78442076
135regulation of necroptotic process (GO:0060544)2.78336353
136phospholipid efflux (GO:0033700)2.78330477
137granulocyte activation (GO:0036230)2.78238178
138mannose metabolic process (GO:0006013)2.78065464
139negative regulation of interleukin-6 production (GO:0032715)2.77965717
140cholesterol efflux (GO:0033344)2.77022221
141regulation of tolerance induction (GO:0002643)2.77017950
142negative thymic T cell selection (GO:0045060)2.76228886
143plasma lipoprotein particle assembly (GO:0034377)2.76096893
144epoxygenase P450 pathway (GO:0019373)2.76055827
145negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75688719
146dicarboxylic acid catabolic process (GO:0043649)2.75620881
147microglial cell activation (GO:0001774)2.75312907
148fatty acid oxidation (GO:0019395)2.74702868
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73710157
150response to laminar fluid shear stress (GO:0034616)2.72221009
151protein-lipid complex assembly (GO:0065005)2.71852519
152histone H3-K36 demethylation (GO:0070544)2.71824205
153regulation of fatty acid oxidation (GO:0046320)2.71208582
154negative T cell selection (GO:0043383)2.70747907
155amino-acid betaine transport (GO:0015838)2.69715710
156carnitine transport (GO:0015879)2.69715710
157immunoglobulin mediated immune response (GO:0016064)2.69042405
158protein localization to endosome (GO:0036010)2.68388386
159lipid oxidation (GO:0034440)2.67490266
160myeloid cell activation involved in immune response (GO:0002275)2.67120630
161fatty acid catabolic process (GO:0009062)2.66384921
162macroautophagy (GO:0016236)2.66366594
163carnitine transmembrane transport (GO:1902603)2.66116057
164positive regulation of triglyceride metabolic process (GO:0090208)2.64794493
165monocarboxylic acid catabolic process (GO:0072329)2.63895472
166negative regulation of cell size (GO:0045792)2.62258304
167regulation of mast cell activation involved in immune response (GO:0033006)2.61634000
168hormone catabolic process (GO:0042447)2.60684105
169negative regulation of protein activation cascade (GO:2000258)2.60594489
170neutrophil mediated immunity (GO:0002446)2.60265588
171positive regulation of fatty acid metabolic process (GO:0045923)2.59844356
172defense response to protozoan (GO:0042832)2.59248720
173regulation of fatty acid biosynthetic process (GO:0042304)2.58130257
174carboxylic acid catabolic process (GO:0046395)2.57658101
175organic acid catabolic process (GO:0016054)2.57658101
176valine metabolic process (GO:0006573)2.57100705
177sterol homeostasis (GO:0055092)2.56090883
178pyrimidine nucleobase catabolic process (GO:0006208)2.55958486
179cellular response to interleukin-15 (GO:0071350)2.55005346
180positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53726543
181positive regulation of cellular amide metabolic process (GO:0034250)2.53135238
182regulation of T cell mediated cytotoxicity (GO:0001914)2.51277898
183response to type I interferon (GO:0034340)2.50274214
184negative regulation of type 2 immune response (GO:0002829)2.49412070
185positive regulation of Rap GTPase activity (GO:0032854)2.48602221
186cellular response to type I interferon (GO:0071357)2.48214092
187type I interferon signaling pathway (GO:0060337)2.48214092
188activated T cell proliferation (GO:0050798)2.47453999
189negative regulation of T-helper cell differentiation (GO:0045623)2.46769588
190negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.46769588
191regulation of regulated secretory pathway (GO:1903305)2.46735605
192T cell migration (GO:0072678)2.45770690
193regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.45666869
194negative regulation of innate immune response (GO:0045824)2.44861417
195lipopolysaccharide-mediated signaling pathway (GO:0031663)2.44110457
196negative regulation of cytokine production involved in immune response (GO:0002719)2.40679583
197positive regulation of mast cell activation (GO:0033005)2.40348576
198regulation of mast cell activation (GO:0033003)2.39839548
199regulation of ARF protein signal transduction (GO:0032012)2.39141480
200JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37982288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.07452419
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.63054208
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.10158418
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.99181737
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.36509141
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.29689255
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.18069516
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11698083
9VDR_21846776_ChIP-Seq_THP-1_Human3.00962501
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.94881803
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.91361115
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86365847
13MYC_22102868_ChIP-Seq_BL_Human2.68061614
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50332085
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50211746
16VDR_24763502_ChIP-Seq_THP-1_Human2.34991599
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22842947
18MAF_26560356_Chip-Seq_TH1_Human2.22519738
19ZNF263_19887448_ChIP-Seq_K562_Human2.21654420
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20048829
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.12996595
22RUNX_20019798_ChIP-Seq_JUKART_Human2.12274832
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.08898217
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08818770
25EGR1_23403033_ChIP-Seq_LIVER_Mouse2.06456489
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01543248
27EZH2_22144423_ChIP-Seq_EOC_Human2.01524289
28CLOCK_20551151_ChIP-Seq_293T_Human1.98032322
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95894102
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95854431
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.94992514
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92152865
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90802437
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.90638055
35SPI1_23127762_ChIP-Seq_K562_Human1.88829651
36UTX_26944678_Chip-Seq_JUKART_Human1.85066364
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83732503
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82547468
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78800931
40MAF_26560356_Chip-Seq_TH2_Human1.77758023
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.75996729
42* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71971613
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69800807
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64464517
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.64254974
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.61179014
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60967893
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55093791
49SCL_19346495_ChIP-Seq_HPC-7_Human1.54322638
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53877236
51SPI1_23547873_ChIP-Seq_NB4_Human1.48156668
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46781836
53MYB_26560356_Chip-Seq_TH2_Human1.45926785
54MYB_26560356_Chip-Seq_TH1_Human1.45158435
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44552401
56KDM2B_26808549_Chip-Seq_K562_Human1.44455224
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42813345
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42793892
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41581816
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.38878192
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38202770
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38076106
63* LXR_22292898_ChIP-Seq_THP-1_Human1.37048005
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36988997
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36843723
66KDM2B_26808549_Chip-Seq_DND41_Human1.35562357
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34118330
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.32486128
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31909688
70VDR_24787735_ChIP-Seq_THP-1_Human1.30115301
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29846778
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29723944
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29591686
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.28798889
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25849048
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25650461
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25014967
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24390152
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23408885
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22935771
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22063551
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.20245471
83DROSHA_22980978_ChIP-Seq_HELA_Human1.18324511
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.16964122
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15240751
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14958062
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13962195
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13120521
89PU_27001747_Chip-Seq_BMDM_Mouse1.13108978
90CREB1_26743006_Chip-Seq_LNCaP_Human1.12809778
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.12349913
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11674758
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.11156547
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.11156547
95P68_20966046_ChIP-Seq_HELA_Human1.10497017
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09457487
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09046196
98BCOR_27268052_Chip-Seq_Bcells_Human1.08897939
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.08759051
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08728439
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08667699
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07717912
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07606503
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07439161
105GATA3_27048872_Chip-Seq_THYMUS_Human1.07138499
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06301510
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05156754
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02226578
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01781836
110HNF4A_19822575_ChIP-Seq_HepG2_Human1.01723555
111NCOR1_26117541_ChIP-Seq_K562_Human1.01415594
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01369378
113* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01038450
114RACK7_27058665_Chip-Seq_MCF-7_Human0.99043439
115TRIM28_21343339_ChIP-Seq_HEK293_Human0.99009523
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98439477
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98386105
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97376800
119GATA2_19941826_ChIP-Seq_K562_Human0.97153303
120MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97019472
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97015117
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96954567
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96302517
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95704114
125TCF7_22412390_ChIP-Seq_EML_Mouse0.95546028
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94906372
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94685639
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.93750190
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93279929
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92143056
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90769933
132GATA1_19941826_ChIP-Seq_K562_Human0.90673422
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90476305
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88574131
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87976851
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.87706018
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87619378
138REST_21632747_ChIP-Seq_MESCs_Mouse0.85381796
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.84248033
140ZNF274_21170338_ChIP-Seq_K562_Hela0.84232064
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83308056
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82115561
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.81907121
144AHR_22903824_ChIP-Seq_MCF-7_Human0.81347812
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80528425
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80360562
147CTCF_27219007_Chip-Seq_Bcells_Human0.80047408
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.79030846
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77854917
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.77768117
151SMC4_20622854_ChIP-Seq_HELA_Human0.77280440
152AR_21572438_ChIP-Seq_LNCaP_Human0.76316626
153BCAT_22108803_ChIP-Seq_LS180_Human0.75308533
154AR_19668381_ChIP-Seq_PC3_Human0.74812415
155NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74541932
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73804062
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.73800654
158KLF4_19829295_ChIP-Seq_ESCs_Human0.73416187
159ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72719268
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.72406498
161RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71652073
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.71481478
163NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.71459086
164RNF2_18974828_ChIP-Seq_MESCs_Mouse0.70585194
165EZH2_18974828_ChIP-Seq_MESCs_Mouse0.70585194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.37667983
2MP0005360_urolithiasis5.51081038
3MP0005085_abnormal_gallbladder_physiolo4.70063463
4MP0005365_abnormal_bile_salt4.53332095
5MP0003436_decreased_susceptibility_to3.69509290
6MP0003705_abnormal_hypodermis_morpholog3.33276987
7MP0003252_abnormal_bile_duct3.33271835
8MP0008875_abnormal_xenobiotic_pharmacok3.32418149
9MP0003724_increased_susceptibility_to3.27839526
10MP0010329_abnormal_lipoprotein_level2.93294027
11MP0005451_abnormal_body_composition2.92544815
12MP0001835_abnormal_antigen_presentation2.53077300
13MP0000685_abnormal_immune_system2.44010136
14MP0002419_abnormal_innate_immunity2.40961040
15MP0001800_abnormal_humoral_immune2.37142021
16MP0003195_calcinosis2.36967249
17MP0005083_abnormal_biliary_tract2.33561320
18MP0002837_dystrophic_cardiac_calcinosis2.33107961
19MP0001790_abnormal_immune_system2.32259035
20MP0005387_immune_system_phenotype2.32259035
21MP0003763_abnormal_thymus_physiology2.27030014
22MP0005025_abnormal_response_to2.23367532
23MP0005000_abnormal_immune_tolerance2.22747902
24MP0003183_abnormal_peptide_metabolism2.18364794
25MP0001666_abnormal_nutrient_absorption2.15437189
26MP0005332_abnormal_amino_acid2.11989310
27MP0010234_abnormal_vibrissa_follicle2.11826937
28MP0003806_abnormal_nucleotide_metabolis2.08221692
29MP0003828_pulmonary_edema2.04169260
30MP0002723_abnormal_immune_serum2.00499683
31MP0002452_abnormal_antigen_presenting2.00157233
32MP0002420_abnormal_adaptive_immunity1.99747559
33MP0001819_abnormal_immune_cell1.97086539
34MP0004130_abnormal_muscle_cell1.96600997
35MP0009785_altered_susceptibility_to1.96441900
36MP0003329_amyloid_beta_deposits1.95912354
37MP0002118_abnormal_lipid_homeostasis1.95221337
38MP0005671_abnormal_response_to1.94155783
39MP0008260_abnormal_autophagy1.93848352
40MP0004510_myositis1.91922449
41MP0004947_skin_inflammation1.89121033
42MP0009840_abnormal_foam_cell1.88357639
43MP0000609_abnormal_liver_physiology1.84350705
44MP0001533_abnormal_skeleton_physiology1.80306368
45MP0005670_abnormal_white_adipose1.78482953
46MP0003191_abnormal_cellular_cholesterol1.75540099
47MP0009780_abnormal_chondrocyte_physiolo1.74857379
48MP0009333_abnormal_splenocyte_physiolog1.74213109
49MP0003646_muscle_fatigue1.71245203
50MP0008961_abnormal_basal_metabolism1.68316002
51MP0004859_abnormal_synaptic_plasticity1.67139815
52MP0003300_gastrointestinal_ulcer1.66669480
53MP0002909_abnormal_adrenal_gland1.64494003
54MP0000604_amyloidosis1.60123377
55MP0004381_abnormal_hair_follicle1.59075725
56MP0002148_abnormal_hypersensitivity_rea1.57670047
57MP0002405_respiratory_system_inflammati1.55292369
58MP0003172_abnormal_lysosome_physiology1.52568125
59MP0002398_abnormal_bone_marrow1.52451592
60MP0000716_abnormal_immune_system1.52319690
61MP0006082_CNS_inflammation1.50908190
62MP0000749_muscle_degeneration1.50050299
63MP0005464_abnormal_platelet_physiology1.49219403
64MP0005410_abnormal_fertilization1.47901337
65MP0005666_abnormal_adipose_tissue1.46876639
66MP0010155_abnormal_intestine_physiology1.46430939
67MP0004185_abnormal_adipocyte_glucose1.43822366
68MP0002138_abnormal_hepatobiliary_system1.39122741
69MP0001845_abnormal_inflammatory_respons1.35983976
70MP0002822_catalepsy1.34228514
71MP0002998_abnormal_bone_remodeling1.33813468
72MP0002332_abnormal_exercise_endurance1.33200327
73MP0001873_stomach_inflammation1.31144086
74MP0003868_abnormal_feces_composition1.30300266
75MP0005584_abnormal_enzyme/coenzyme_acti1.29053648
76MP0002132_abnormal_respiratory_system1.28186613
77MP0003091_abnormal_cell_migration1.27861761
78MP0005319_abnormal_enzyme/_coenzyme1.27660495
79MP0000703_abnormal_thymus_morphology1.25587569
80MP0002722_abnormal_immune_system1.25111678
81MP0009384_cardiac_valve_regurgitation1.21876040
82MP0000013_abnormal_adipose_tissue1.21393383
83MP0002971_abnormal_brown_adipose1.20922317
84MP0000759_abnormal_skeletal_muscle1.20705345
85MP0005310_abnormal_salivary_gland1.19922228
86MP0005375_adipose_tissue_phenotype1.19150235
87MP0000689_abnormal_spleen_morphology1.18572321
88MP0008469_abnormal_protein_level1.17370032
89MP0003866_abnormal_defecation1.17098713
90MP0009278_abnormal_bone_marrow1.16524475
91MP0000750_abnormal_muscle_regeneration1.16299402
92MP0002429_abnormal_blood_cell1.15768522
93MP0003283_abnormal_digestive_organ1.13559827
94MP0000858_altered_metastatic_potential1.13115977
95MP0004043_abnormal_pH_regulation1.11880633
96MP0002078_abnormal_glucose_homeostasis1.11534086
97MP0005409_darkened_coat_color1.11457142
98MP0000003_abnormal_adipose_tissue1.10655066
99MP0009643_abnormal_urine_homeostasis1.10199726
100MP0004019_abnormal_vitamin_homeostasis1.10095164
101MP0005166_decreased_susceptibility_to1.09162298
102MP0002877_abnormal_melanocyte_morpholog1.08954343
103MP0001851_eye_inflammation1.06041604
104MP0003453_abnormal_keratinocyte_physiol1.04995281
105MP0004883_abnormal_blood_vessel0.98409817
106MP0002277_abnormal_respiratory_mucosa0.97811523
107MP0005535_abnormal_body_temperature0.96391067
108MP0000747_muscle_weakness0.94898380
109MP0002166_altered_tumor_susceptibility0.94307619
110MP0005334_abnormal_fat_pad0.92678093
111MP0003690_abnormal_glial_cell0.92486015
112MP0002106_abnormal_muscle_physiology0.91375779
113MP0004145_abnormal_muscle_electrophysio0.91004583
114MP0002269_muscular_atrophy0.90858350
115MP0002928_abnormal_bile_duct0.90339886
116MP0005167_abnormal_blood-brain_barrier0.88861266
117MP0002396_abnormal_hematopoietic_system0.87979502
118MP0005076_abnormal_cell_differentiation0.87020780
119MP0003656_abnormal_erythrocyte_physiolo0.84245694
120MP0000733_abnormal_muscle_development0.83774556
121MP0000465_gastrointestinal_hemorrhage0.83590804
122MP0003635_abnormal_synaptic_transmissio0.83578713
123MP0005623_abnormal_meninges_morphology0.82273685
124MP0005448_abnormal_energy_balance0.82179871
125MP0003633_abnormal_nervous_system0.81866660
126MP0002009_preneoplasia0.81715641
127MP0004087_abnormal_muscle_fiber0.81153128
128MP0004233_abnormal_muscle_weight0.81067640
129MP0001958_emphysema0.80583062
130MP0008438_abnormal_cutaneous_collagen0.80573522
131MP0000598_abnormal_liver_morphology0.80472154
132MP0003279_aneurysm0.78367744
133MP0003303_peritoneal_inflammation0.78365929
134MP0009764_decreased_sensitivity_to0.78276804
135MP0003448_altered_tumor_morphology0.77331692
136MP0002896_abnormal_bone_mineralization0.76823167
137MP0004858_abnormal_nervous_system0.76453022
138MP0004270_analgesia0.75994811
139MP0001765_abnormal_ion_homeostasis0.74553480
140MP0005390_skeleton_phenotype0.74476824
141MP0000751_myopathy0.74361472
142MP0005187_abnormal_penis_morphology0.74318439
143MP0004484_altered_response_of0.74059324
144MP0002063_abnormal_learning/memory/cond0.74006877
145MP0002933_joint_inflammation0.73936765
146MP0005220_abnormal_exocrine_pancreas0.72901164
147MP0003045_fibrosis0.72630865
148MP0002254_reproductive_system_inflammat0.70596692
149MP0001756_abnormal_urination0.69904328
150MP0001944_abnormal_pancreas_morphology0.69430929
151MP0002234_abnormal_pharynx_morphology0.69295834
152MP0008874_decreased_physiological_sensi0.68467352
153MP0001661_extended_life_span0.68095681
154MP0010368_abnormal_lymphatic_system0.66626174
155MP0005330_cardiomyopathy0.66139113
156MP0003075_altered_response_to0.66101654
157MP0004885_abnormal_endolymph0.63033590
158MP0002970_abnormal_white_adipose0.62242846
159MP0003221_abnormal_cardiomyocyte_apopto0.62003205
160MP0005636_abnormal_mineral_homeostasis0.60996873
161MP0003953_abnormal_hormone_level0.60779492
162MP0002168_other_aberrant_phenotype0.60749298
163MP0009672_abnormal_birth_weight0.60528189
164MP0009642_abnormal_blood_homeostasis0.60296108
165MP0003631_nervous_system_phenotype0.54142541
166MP0004036_abnormal_muscle_relaxation0.53406155
167MP0005647_abnormal_sex_gland0.52984936
168MP0010630_abnormal_cardiac_muscle0.52361652
169MP0005058_abnormal_lysosome_morphology0.51641016
170MP0004264_abnormal_extraembryonic_tissu0.50857135
171MP0001984_abnormal_olfaction0.48686650
172MP0003959_abnormal_lean_body0.48461313
173MP0003566_abnormal_cell_adhesion0.44895890

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.42940884
2Eczematoid dermatitis (HP:0000976)5.29253202
3Intrahepatic cholestasis (HP:0001406)4.30391646
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.24533810
5Xanthomatosis (HP:0000991)4.21885995
6Abnormality of macrophages (HP:0004311)4.04276658
7Complement deficiency (HP:0004431)4.03821066
8Muscle fiber inclusion bodies (HP:0100299)3.97715510
9Recurrent abscess formation (HP:0002722)3.96881370
10Recurrent bacterial skin infections (HP:0005406)3.92201264
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.83112727
12Nemaline bodies (HP:0003798)3.83055523
13Myositis (HP:0100614)3.79030017
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.68589061
15Orchitis (HP:0100796)3.65677749
16Ketosis (HP:0001946)3.63655036
17Hypobetalipoproteinemia (HP:0003563)3.50146231
18Hyperlipoproteinemia (HP:0010980)3.48783493
19Hypoglycemic coma (HP:0001325)3.44975742
20Retrobulbar optic neuritis (HP:0100654)3.44198514
21Optic neuritis (HP:0100653)3.44198514
22Gastrointestinal infarctions (HP:0005244)3.43202409
23Recurrent gram-negative bacterial infections (HP:0005420)3.43148423
24Ketoacidosis (HP:0001993)3.27296196
25Type 1 muscle fiber predominance (HP:0003803)3.20894023
26Hypoalphalipoproteinemia (HP:0003233)3.11534816
27Hyperammonemia (HP:0001987)3.09965938
28Epidermoid cyst (HP:0200040)3.06311491
29Hypolipoproteinemia (HP:0010981)3.04724812
30Abnormality of the common coagulation pathway (HP:0010990)2.99534485
31Stomatitis (HP:0010280)2.98029525
32Muscle fiber splitting (HP:0003555)2.93013653
33Abnormality of complement system (HP:0005339)2.91714329
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.91398212
35Spontaneous hematomas (HP:0007420)2.88894985
36Mediastinal lymphadenopathy (HP:0100721)2.85915852
37Increased connective tissue (HP:0009025)2.82666192
38Recurrent fungal infections (HP:0002841)2.82162012
39Hyperglycinemia (HP:0002154)2.81655359
40Asymmetric septal hypertrophy (HP:0001670)2.80874962
41Cerebral inclusion bodies (HP:0100314)2.78671744
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.78568009
43Abnormality of skeletal muscle fiber size (HP:0012084)2.75883111
44Prolonged partial thromboplastin time (HP:0003645)2.75152786
45Hyperglycinuria (HP:0003108)2.74807617
46Myopathic facies (HP:0002058)2.74723136
47Meningitis (HP:0001287)2.71190058
48Chronic obstructive pulmonary disease (HP:0006510)2.69298336
49Obstructive lung disease (HP:0006536)2.69298336
50Skin nodule (HP:0200036)2.67401772
51Abnormality of the lower motor neuron (HP:0002366)2.67377833
52Gingivitis (HP:0000230)2.67292009
53Abnormality of glycine metabolism (HP:0010895)2.66281100
54Abnormality of serine family amino acid metabolism (HP:0010894)2.66281100
55Gout (HP:0001997)2.65751031
56Ulnar deviation of the wrist (HP:0003049)2.64684944
57EMG: myopathic abnormalities (HP:0003458)2.63400588
58Myocardial infarction (HP:0001658)2.62535171
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62130039
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.59151679
61Distal lower limb muscle weakness (HP:0009053)2.58331333
62Increased IgE level (HP:0003212)2.55321032
63Increased variability in muscle fiber diameter (HP:0003557)2.55145818
64Elevated erythrocyte sedimentation rate (HP:0003565)2.54107451
65Back pain (HP:0003418)2.53927314
66Obstructive sleep apnea (HP:0002870)2.53099100
67Abnormality of the Achilles tendon (HP:0005109)2.51600902
68Hyperinsulinemic hypoglycemia (HP:0000825)2.50659094
69Cellulitis (HP:0100658)2.49581586
70Recurrent skin infections (HP:0001581)2.47730165
71Sensorimotor neuropathy (HP:0007141)2.43608767
72Abnormality of the intrinsic pathway (HP:0010989)2.43566693
73Slow saccadic eye movements (HP:0000514)2.42556381
74Vasculitis (HP:0002633)2.42127367
75Chest pain (HP:0100749)2.40580508
76Keratoconjunctivitis sicca (HP:0001097)2.40484426
77Hypercholesterolemia (HP:0003124)2.39659166
78Neurofibrillary tangles (HP:0002185)2.39373068
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.36532928
80Abnormality of glycolipid metabolism (HP:0010969)2.32290438
81Abnormality of liposaccharide metabolism (HP:0010968)2.32290438
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.32290438
83Segmental peripheral demyelination/remyelination (HP:0003481)2.30628319
84Lymphangioma (HP:0100764)2.29406674
85Recurrent cutaneous fungal infections (HP:0011370)2.27595473
86Chronic mucocutaneous candidiasis (HP:0002728)2.27595473
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26112070
88Hypoglycemic seizures (HP:0002173)2.25538964
89Polycythemia (HP:0001901)2.24291235
90Encephalitis (HP:0002383)2.23493225
91Fat malabsorption (HP:0002630)2.22150417
92Abnormality of the fingertips (HP:0001211)2.18440382
93Abnormal gallbladder physiology (HP:0012438)2.16696449
94Cholecystitis (HP:0001082)2.16696449
95Hypochromic anemia (HP:0001931)2.15787755
96Urticaria (HP:0001025)2.15769140
97Gastrointestinal inflammation (HP:0004386)2.15507584
98Inflammation of the large intestine (HP:0002037)2.15472119
99Colitis (HP:0002583)2.15230591
100Macroorchidism (HP:0000053)2.14170688
101Arterial thrombosis (HP:0004420)2.13878218
102Global brain atrophy (HP:0002283)2.13598990
103Hepatocellular carcinoma (HP:0001402)2.10720972
104Hemoptysis (HP:0002105)2.10120163
105Pustule (HP:0200039)2.10089706
106Myoglobinuria (HP:0002913)2.09194241
107Abnormality of purine metabolism (HP:0004352)2.08330672
108Achilles tendon contracture (HP:0001771)2.07865185
109Abnormality of the left ventricular outflow tract (HP:0011103)2.07687563
110Subaortic stenosis (HP:0001682)2.07687563
111Keratoconjunctivitis (HP:0001096)2.07085235
112Amyloidosis (HP:0011034)2.07008272
113Prolonged bleeding time (HP:0003010)2.04251844
114Bulbar palsy (HP:0001283)2.04204315
115Mitral stenosis (HP:0001718)2.03958212
116Status epilepticus (HP:0002133)2.03009512
117Abnormality of the endocardium (HP:0004306)2.02950081
118Thin bony cortex (HP:0002753)2.01565103
119Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01366836
120Turricephaly (HP:0000262)2.00276603
121Peritonitis (HP:0002586)2.00126138
122Muscle hypertrophy of the lower extremities (HP:0008968)1.99936016
123Dysostosis multiplex (HP:0000943)1.99844028
124Hyperglycemia (HP:0003074)1.98879866
125Pulmonary infiltrates (HP:0002113)1.98031910
126Cholelithiasis (HP:0001081)1.97698962
127Abnormal cartilage morphology (HP:0002763)1.96065950
128Frequent falls (HP:0002359)1.95841226
129Easy fatigability (HP:0003388)1.95117828
130Abnormal gallbladder morphology (HP:0012437)1.94605288
131Hyporeflexia of lower limbs (HP:0002600)1.94374183
132Gingival bleeding (HP:0000225)1.94246278
133T lymphocytopenia (HP:0005403)1.92645832
134Distal lower limb amyotrophy (HP:0008944)1.92513924
135Recurrent viral infections (HP:0004429)1.92325991
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91628499
137Cerebral aneurysm (HP:0004944)1.90645157
138Abnormality of fatty-acid metabolism (HP:0004359)1.90192468
139Difficulty running (HP:0009046)1.88442442
140Distal arthrogryposis (HP:0005684)1.88211767
141Neonatal onset (HP:0003623)1.87642097
142Resting tremor (HP:0002322)1.86272189
143Osteomyelitis (HP:0002754)1.86258689
144Round ear (HP:0100830)1.86235040
145Increased CSF protein (HP:0002922)1.85744315
146Epistaxis (HP:0000421)1.84348392
147Acne (HP:0001061)1.84080707
148Hyperbilirubinemia (HP:0002904)1.83714817
149Exercise-induced myalgia (HP:0003738)1.83713260
150Dysmetric saccades (HP:0000641)1.83609591
151Pulmonary embolism (HP:0002204)1.83380999
152Urinary glycosaminoglycan excretion (HP:0003541)1.83312502
153Mucopolysacchariduria (HP:0008155)1.83312502
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83292840
155Abnormality of polysaccharide metabolism (HP:0011012)1.83292840
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83292840
157Increased serum ferritin (HP:0003281)1.81889893
158Intention tremor (HP:0002080)1.80896316
159Fatigue (HP:0012378)1.80756396
160Retinal atrophy (HP:0001105)1.80611696
161Gastrointestinal stroma tumor (HP:0100723)1.80203695
162Calf muscle hypertrophy (HP:0008981)1.79386687
163Rhabdomyolysis (HP:0003201)1.78370525
164Abnormality of T cell number (HP:0011839)1.78361981
165Malnutrition (HP:0004395)1.78305961
166Restrictive lung disease (HP:0002091)1.77151129
167Aneurysm (HP:0002617)1.76835713
168Insidious onset (HP:0003587)1.75753049
169Termporal pattern (HP:0011008)1.75753049
170Abnormal social behavior (HP:0012433)1.74523140
171Impaired social interactions (HP:0000735)1.74523140
172Abnormality of methionine metabolism (HP:0010901)1.74136201
173Death in childhood (HP:0003819)1.74074972
174Mitral valve prolapse (HP:0001634)1.72816724
175Hypochromic microcytic anemia (HP:0004840)1.72600240
176Acanthocytosis (HP:0001927)1.72237738
177Visceral angiomatosis (HP:0100761)1.71854292
178Late onset (HP:0003584)1.71163696
179Abnormality of the pancreatic islet cells (HP:0006476)1.69166129
180Abnormality of endocrine pancreas physiology (HP:0012093)1.69166129
181Abnormality of nucleobase metabolism (HP:0010932)1.67758530
182Hamartoma of the eye (HP:0010568)1.67723035
183Joint hemorrhage (HP:0005261)1.67599928
184Reticulocytosis (HP:0001923)1.65496466
185Insomnia (HP:0100785)1.65301701
186Long toe (HP:0010511)1.63947748
187Exercise-induced muscle cramps (HP:0003710)1.62771545
188Hemangiomatosis (HP:0007461)1.61094137
189Abnormality of the gallbladder (HP:0005264)1.60823945
190Hemorrhage of the eye (HP:0011885)1.60053890
191Impaired vibration sensation in the lower limbs (HP:0002166)1.59715526
192Spastic diplegia (HP:0001264)1.59382107
193Delayed CNS myelination (HP:0002188)1.58724467
194Stroke (HP:0001297)1.58685038
195Increased purine levels (HP:0004368)1.58430448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.91021469
2PRPF4B3.40898402
3RIPK43.11743067
4MAP3K103.03542990
5PKN22.73680763
6PRKD32.63763572
7MAP4K12.60719724
8MAP2K32.60640339
9ERN12.53711833
10IRAK42.51054347
11ICK2.19711184
12SIK12.17894852
13BLK2.16466292
14TYK22.08813565
15BCKDK2.06122109
16RIPK12.02050234
17MAP3K92.01321882
18PDK41.94362297
19PDK31.94362297
20LATS11.93117611
21CSK1.93086280
22OBSCN1.89317482
23MAP3K131.82003287
24CAMK1G1.75668112
25KSR21.74489410
26MAP3K31.65625723
27ZAP701.61332380
28MAP3K21.60278189
29INSRR1.59594714
30MAP2K41.48478685
31DAPK21.48429869
32TNK21.42561818
33PDGFRA1.42417061
34MAP3K111.40949938
35FGFR41.30614431
36PTK61.28448681
37CAMK1D1.27768299
38PAK31.27257763
39FES1.26963937
40MAP3K141.25318039
41STK381.24215831
42MAP3K71.23244038
43NTRK11.22024363
44FRK1.21847826
45PAK61.19791753
46MAP3K41.19714031
47LATS21.18653896
48RET1.16436715
49TYRO31.16423705
50PRKCH1.16092666
51WNK41.13845051
52BTK1.13658988
53SIK21.11966571
54HCK1.11211699
55JAK31.11120416
56DYRK1B1.10487709
57TAOK21.09614850
58SMG11.09524306
59PHKG21.07994260
60PHKG11.07994260
61TBK11.06590443
62IRAK21.05816835
63SIK31.05659403
64CAMKK11.04470015
65PIK3CG1.03279734
66IRAK31.01895691
67IKBKE1.01616226
68TTN0.99614900
69GRK60.98399361
70FGFR20.97721249
71PDK20.95931047
72SYK0.95491931
73PTK2B0.92788980
74CDC42BPA0.90727676
75CAMKK20.89837905
76MARK30.88996026
77PDPK10.88172273
78MST1R0.87712966
79TAOK10.87652491
80PRKAA10.86535578
81MTOR0.84307517
82PDK10.84001724
83ALK0.83995368
84STK110.83095911
85IRAK10.82889400
86EPHB10.82638482
87NTRK30.81030660
88EEF2K0.80324716
89PDGFRB0.79655099
90KSR10.79302015
91PTK20.78468029
92BMX0.78359739
93MINK10.77976679
94DMPK0.77707216
95SCYL20.76478407
96TXK0.75981467
97MET0.74037125
98CSF1R0.73881881
99MARK10.72827670
100MAPK70.72610971
101MOS0.72316647
102SGK30.71633259
103ITK0.70705127
104MAP3K10.70469518
105FGR0.70345921
106MARK20.67957735
107RPS6KL10.67866378
108RPS6KC10.67866378
109LMTK20.67278274
110TAOK30.66303251
111DDR20.65090316
112JAK20.64897006
113GSK3A0.64821097
114STK100.64583297
115SGK20.64432960
116EPHA40.64221769
117LCK0.64094565
118LYN0.63284571
119ERBB20.63116748
120WNK10.62792320
121JAK10.62333853
122NEK90.62188941
123PRKD20.61670132
124RPS6KA20.61619095
125PRKAA20.61390229
126PRKCZ0.61376072
127TGFBR20.61260054
128MAP2K10.60185049
129CDK60.59585026
130PRKD10.59108038
131FGFR30.58795431
132ARAF0.58502131
133CAMK40.57338284
134CDK50.56576351
135TRPM70.56529837
136YES10.56510717
137RPS6KA60.54607626
138PAK20.53911840
139HIPK20.53148922
140FER0.51926451
141LRRK20.51819618
142UHMK10.51061809
143ERBB40.50446782
144MAPK120.50219937
145MAPK110.47385225
146PNCK0.46511529
147STK390.46111438
148CDK120.45208908
149EPHB20.43716364
150TESK10.43550391
151MAP3K60.43114042
152IKBKB0.41901203
153SGK2230.38423913

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.30006785
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.15124687
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12205586
4Arginine biosynthesis_Homo sapiens_hsa002202.71197464
5Osteoclast differentiation_Homo sapiens_hsa043802.43755081
6B cell receptor signaling pathway_Homo sapiens_hsa046622.33596951
7Fatty acid degradation_Homo sapiens_hsa000712.26811553
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22067700
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15775414
10Leishmaniasis_Homo sapiens_hsa051402.11453787
11Butanoate metabolism_Homo sapiens_hsa006502.05273166
12Propanoate metabolism_Homo sapiens_hsa006402.04091628
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02169975
14Fatty acid metabolism_Homo sapiens_hsa012121.96664741
15Tryptophan metabolism_Homo sapiens_hsa003801.93261070
16Acute myeloid leukemia_Homo sapiens_hsa052211.92367032
17PPAR signaling pathway_Homo sapiens_hsa033201.91306250
18Fatty acid biosynthesis_Homo sapiens_hsa000611.87802207
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81315862
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81218204
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81116197
22T cell receptor signaling pathway_Homo sapiens_hsa046601.79846497
23Bile secretion_Homo sapiens_hsa049761.77320451
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76373597
25Complement and coagulation cascades_Homo sapiens_hsa046101.76116234
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71679318
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68252947
28Tuberculosis_Homo sapiens_hsa051521.66157974
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65811642
30Non-small cell lung cancer_Homo sapiens_hsa052231.59487636
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58014805
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53616651
33Other glycan degradation_Homo sapiens_hsa005111.50537901
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41217823
35Pyruvate metabolism_Homo sapiens_hsa006201.39633683
36Sulfur metabolism_Homo sapiens_hsa009201.39566400
37Measles_Homo sapiens_hsa051621.36773493
38Chemokine signaling pathway_Homo sapiens_hsa040621.36311021
39Malaria_Homo sapiens_hsa051441.35403447
40Toxoplasmosis_Homo sapiens_hsa051451.35284384
41Chronic myeloid leukemia_Homo sapiens_hsa052201.35144508
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.29663135
43TNF signaling pathway_Homo sapiens_hsa046681.29576751
44Primary immunodeficiency_Homo sapiens_hsa053401.28627509
45Graft-versus-host disease_Homo sapiens_hsa053321.27755437
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26966296
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.25933273
48Lysine degradation_Homo sapiens_hsa003101.25787728
49Influenza A_Homo sapiens_hsa051641.25531096
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.24653549
51Allograft rejection_Homo sapiens_hsa053301.23492634
52Peroxisome_Homo sapiens_hsa041461.21564593
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18804968
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.18721607
55Fat digestion and absorption_Homo sapiens_hsa049751.18709877
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18599761
57Endometrial cancer_Homo sapiens_hsa052131.17947924
58Viral myocarditis_Homo sapiens_hsa054161.17309329
59Hepatitis B_Homo sapiens_hsa051611.15845654
60Hepatitis C_Homo sapiens_hsa051601.15265275
61Pancreatic cancer_Homo sapiens_hsa052121.14764228
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13942773
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13754850
64Autoimmune thyroid disease_Homo sapiens_hsa053201.13371038
65Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13135599
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10937102
67Prolactin signaling pathway_Homo sapiens_hsa049171.09472294
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09056646
69Notch signaling pathway_Homo sapiens_hsa043301.08768546
70Carbon metabolism_Homo sapiens_hsa012001.07456298
71FoxO signaling pathway_Homo sapiens_hsa040681.05949686
72beta-Alanine metabolism_Homo sapiens_hsa004101.05038923
73ABC transporters_Homo sapiens_hsa020101.04536221
74Selenocompound metabolism_Homo sapiens_hsa004501.03217909
75Hematopoietic cell lineage_Homo sapiens_hsa046401.01301903
76Platelet activation_Homo sapiens_hsa046111.00839276
77Maturity onset diabetes of the young_Homo sapiens_hsa049501.00094744
78Glucagon signaling pathway_Homo sapiens_hsa049220.99369737
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98484327
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97464764
81Starch and sucrose metabolism_Homo sapiens_hsa005000.96885417
82Glycerolipid metabolism_Homo sapiens_hsa005610.94731671
83Caffeine metabolism_Homo sapiens_hsa002320.91971074
84Biosynthesis of amino acids_Homo sapiens_hsa012300.89988451
85ErbB signaling pathway_Homo sapiens_hsa040120.89794711
86Insulin resistance_Homo sapiens_hsa049310.89092827
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89036086
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.88620332
89Legionellosis_Homo sapiens_hsa051340.88439472
90Phagosome_Homo sapiens_hsa041450.88414623
91Chemical carcinogenesis_Homo sapiens_hsa052040.86929542
92Choline metabolism in cancer_Homo sapiens_hsa052310.86835147
93Herpes simplex infection_Homo sapiens_hsa051680.84140501
94Apoptosis_Homo sapiens_hsa042100.83957333
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82866735
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.81354720
97Amoebiasis_Homo sapiens_hsa051460.80721785
98Antigen processing and presentation_Homo sapiens_hsa046120.80642502
99Staphylococcus aureus infection_Homo sapiens_hsa051500.79159470
100MAPK signaling pathway_Homo sapiens_hsa040100.78819397
101Endocytosis_Homo sapiens_hsa041440.78422482
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78172001
103Prostate cancer_Homo sapiens_hsa052150.77790353
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77260153
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.77069145
106Phenylalanine metabolism_Homo sapiens_hsa003600.76767294
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.75886206
108Pertussis_Homo sapiens_hsa051330.75384384
109Lysosome_Homo sapiens_hsa041420.74755304
110Dorso-ventral axis formation_Homo sapiens_hsa043200.74540712
111Thyroid cancer_Homo sapiens_hsa052160.74396286
112Histidine metabolism_Homo sapiens_hsa003400.73961070
113Inositol phosphate metabolism_Homo sapiens_hsa005620.73810151
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.72999250
115Sulfur relay system_Homo sapiens_hsa041220.71723441
116AMPK signaling pathway_Homo sapiens_hsa041520.71419253
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.70831479
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.70725569
119Colorectal cancer_Homo sapiens_hsa052100.68898391
120Salmonella infection_Homo sapiens_hsa051320.67888368
121Type I diabetes mellitus_Homo sapiens_hsa049400.67777597
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.67218581
123Insulin signaling pathway_Homo sapiens_hsa049100.65937204
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65813731
125HIF-1 signaling pathway_Homo sapiens_hsa040660.65133756
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65008673
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64987041
128Type II diabetes mellitus_Homo sapiens_hsa049300.64865412
129Insulin secretion_Homo sapiens_hsa049110.64445335
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63044325
131mTOR signaling pathway_Homo sapiens_hsa041500.62890472
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62408234
133African trypanosomiasis_Homo sapiens_hsa051430.61416807
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61011932
135Long-term potentiation_Homo sapiens_hsa047200.60708694
136Tyrosine metabolism_Homo sapiens_hsa003500.59772378
137HTLV-I infection_Homo sapiens_hsa051660.59682618
138Shigellosis_Homo sapiens_hsa051310.56152321
139Bladder cancer_Homo sapiens_hsa052190.56108836
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55893533
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.55687241
142Estrogen signaling pathway_Homo sapiens_hsa049150.55333988
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54872212
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54324510
145Gastric acid secretion_Homo sapiens_hsa049710.52040823
146Focal adhesion_Homo sapiens_hsa045100.51908707
147Oxytocin signaling pathway_Homo sapiens_hsa049210.51903975
148Thyroid hormone synthesis_Homo sapiens_hsa049180.51859257
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51539382
150Viral carcinogenesis_Homo sapiens_hsa052030.51236393
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50731860
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49600324
153Retinol metabolism_Homo sapiens_hsa008300.48962085
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48780400
155Prion diseases_Homo sapiens_hsa050200.47687954
156Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47531571
157Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46529457
158Renin secretion_Homo sapiens_hsa049240.45746005
159Arginine and proline metabolism_Homo sapiens_hsa003300.44709975
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44509679
161Amphetamine addiction_Homo sapiens_hsa050310.44161510
162Glioma_Homo sapiens_hsa052140.42639347
163Fatty acid elongation_Homo sapiens_hsa000620.41554478
164GnRH signaling pathway_Homo sapiens_hsa049120.40888334
165Salivary secretion_Homo sapiens_hsa049700.39444315
166VEGF signaling pathway_Homo sapiens_hsa043700.38939860
167Dopaminergic synapse_Homo sapiens_hsa047280.38438593
168Olfactory transduction_Homo sapiens_hsa047400.38180980
169Central carbon metabolism in cancer_Homo sapiens_hsa052300.35831738
170cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34457009
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.32473337
172Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30204968
173Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29625100
174Vitamin B6 metabolism_Homo sapiens_hsa007500.29243660
175Circadian entrainment_Homo sapiens_hsa047130.28276385
176Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27904893
177Renal cell carcinoma_Homo sapiens_hsa052110.27382961
178GABAergic synapse_Homo sapiens_hsa047270.26382211
179Gap junction_Homo sapiens_hsa045400.26316293

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