TADA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)7.82885683
2chaperone-mediated protein transport (GO:0072321)6.62333606
3maturation of 5.8S rRNA (GO:0000460)6.26766809
4DNA strand elongation (GO:0022616)4.74245155
5barbed-end actin filament capping (GO:0051016)4.70426152
6DNA strand elongation involved in DNA replication (GO:0006271)4.56719507
7formation of translation preinitiation complex (GO:0001731)4.38294154
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35763399
9protein localization to kinetochore (GO:0034501)4.33152346
10ribosomal large subunit biogenesis (GO:0042273)4.31166759
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.26175195
12DNA replication initiation (GO:0006270)4.23927439
13telomere maintenance via semi-conservative replication (GO:0032201)4.16552109
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.12553842
15DNA replication-dependent nucleosome assembly (GO:0006335)4.05215040
16DNA replication-dependent nucleosome organization (GO:0034723)4.05215040
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.04831050
18alternative mRNA splicing, via spliceosome (GO:0000380)4.00572191
19telomere maintenance via telomere lengthening (GO:0010833)3.99154757
20negative regulation of erythrocyte differentiation (GO:0045647)3.97742771
21DNA deamination (GO:0045006)3.96747019
22negative regulation of cell size (GO:0045792)3.95732299
23Golgi transport vesicle coating (GO:0048200)3.93794184
24COPI coating of Golgi vesicle (GO:0048205)3.93794184
25DNA replication checkpoint (GO:0000076)3.92559098
26nuclear pore organization (GO:0006999)3.91250499
27mitotic nuclear envelope disassembly (GO:0007077)3.89699636
28antigen processing and presentation of endogenous antigen (GO:0019883)3.88095125
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.87776976
30DNA unwinding involved in DNA replication (GO:0006268)3.86163999
31protein localization to chromosome, centromeric region (GO:0071459)3.77854648
32modulation by virus of host process (GO:0019054)3.75754913
33ribosomal small subunit assembly (GO:0000028)3.68864756
34nuclear envelope disassembly (GO:0051081)3.67481185
35membrane disassembly (GO:0030397)3.67481185
36regulation of early endosome to late endosome transport (GO:2000641)3.64741172
37telomere maintenance via recombination (GO:0000722)3.58256546
38modulation by symbiont of host cellular process (GO:0044068)3.56020494
39positive regulation of cell cycle checkpoint (GO:1901978)3.53330353
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.53313423
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.53313423
42negative regulation of mRNA processing (GO:0050686)3.52871533
43telomere maintenance via telomerase (GO:0007004)3.46018779
44spliceosomal snRNP assembly (GO:0000387)3.41877052
45negative regulation of RNA splicing (GO:0033119)3.40691103
46regulation of defense response to virus by virus (GO:0050690)3.39213259
47proline biosynthetic process (GO:0006561)3.38929418
48regulation of double-strand break repair via homologous recombination (GO:0010569)3.37997874
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36335797
50negative regulation of epidermis development (GO:0045683)3.35798514
51protein localization to endosome (GO:0036010)3.33509974
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.32637800
53mitotic recombination (GO:0006312)3.31195668
54pentose-phosphate shunt (GO:0006098)3.30544722
55folic acid-containing compound biosynthetic process (GO:0009396)3.30056894
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.27525575
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25496534
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.25496534
59modulation by symbiont of host immune response (GO:0052553)3.25496534
60positive regulation by symbiont of host defense response (GO:0052509)3.25496534
61modulation by symbiont of host defense response (GO:0052031)3.25496534
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25496534
63neutrophil activation involved in immune response (GO:0002283)3.24428967
64attachment of spindle microtubules to kinetochore (GO:0008608)3.23855221
65mitotic metaphase plate congression (GO:0007080)3.22096801
66nucleobase biosynthetic process (GO:0046112)3.20796505
67protein retention in ER lumen (GO:0006621)3.20752572
68negative regulation of epidermal cell differentiation (GO:0045605)3.16822284
69regulation of helicase activity (GO:0051095)3.15952533
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.15818916
71regulation of extracellular matrix disassembly (GO:0010715)3.14035031
72regulation of spindle checkpoint (GO:0090231)3.11924481
73kinetochore assembly (GO:0051382)3.07415268
74protein insertion into membrane (GO:0051205)3.07133152
75modulation by virus of host morphology or physiology (GO:0019048)3.07067244
76nuclear pore complex assembly (GO:0051292)3.06547183
77negative regulation of mRNA metabolic process (GO:1903312)3.06265512
78spliceosomal tri-snRNP complex assembly (GO:0000244)3.04474085
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01793945
80RNA-dependent DNA replication (GO:0006278)3.00512588
81glucose catabolic process (GO:0006007)2.99911973
82positive regulation of Cdc42 GTPase activity (GO:0043089)2.98325219
83cullin deneddylation (GO:0010388)2.96502347
84translational initiation (GO:0006413)2.96104340
85DNA damage response, detection of DNA damage (GO:0042769)2.96069319
86protein K6-linked ubiquitination (GO:0085020)2.95889288
87regulation of mitotic spindle checkpoint (GO:1903504)2.95184636
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95184636
89mitotic sister chromatid segregation (GO:0000070)2.94509042
90maturation of SSU-rRNA (GO:0030490)2.93094051
91ribonucleoprotein complex biogenesis (GO:0022613)2.92590493
92viral transcription (GO:0019083)2.92398151
93transcription-coupled nucleotide-excision repair (GO:0006283)2.92041687
94protein deneddylation (GO:0000338)2.91646022
95positive regulation of blood vessel endothelial cell migration (GO:0043536)2.91363654
96negative regulation of chromosome segregation (GO:0051985)2.90563142
97negative regulation of histone methylation (GO:0031061)2.90503806
98mRNA splicing, via spliceosome (GO:0000398)2.90123629
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.90123629
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89553654
101nuclear envelope organization (GO:0006998)2.89174233
102positive regulation of receptor recycling (GO:0001921)2.89132875
103kinetochore organization (GO:0051383)2.88952294
104pinocytosis (GO:0006907)2.88922205
105termination of RNA polymerase II transcription (GO:0006369)2.88543716
106positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88391933
107mannose metabolic process (GO:0006013)2.87554241
108regulation of leukocyte degranulation (GO:0043300)2.87505857
109mismatch repair (GO:0006298)2.87024079
110RNA splicing, via transesterification reactions (GO:0000375)2.87015015
111negative regulation of phagocytosis (GO:0050765)2.86378889
112protein maturation by protein folding (GO:0022417)2.86354252
113histone H2A acetylation (GO:0043968)2.86265861
114translational termination (GO:0006415)2.85183086
115translational elongation (GO:0006414)2.84775895
116regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.82713910
117regulation of superoxide anion generation (GO:0032928)2.82431908
118positive regulation of protein dephosphorylation (GO:0035307)2.81433715
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81398075
120negative regulation of telomere maintenance (GO:0032205)2.80226947
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.79617383
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79617383
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79617383
124negative regulation of sister chromatid segregation (GO:0033046)2.79617383
125amyloid precursor protein catabolic process (GO:0042987)2.79273431
126histone arginine methylation (GO:0034969)2.79240815
127regulation of mast cell degranulation (GO:0043304)2.78854758
128tRNA methylation (GO:0030488)2.78529523
129negative regulation of cell killing (GO:0031342)2.78098790
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78098790
131establishment of integrated proviral latency (GO:0075713)2.77816691
132glucose 6-phosphate metabolic process (GO:0051156)2.77348417
133GDP-mannose metabolic process (GO:0019673)2.75354962
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74844883
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74843328
136viral mRNA export from host cell nucleus (GO:0046784)2.74729489
137telomere organization (GO:0032200)2.74431732
138rRNA processing (GO:0006364)2.74207762
139protein import into peroxisome matrix (GO:0016558)2.74066073
140stress fiber assembly (GO:0043149)2.73700084
141DNA ligation (GO:0006266)2.72990228
142ribosome biogenesis (GO:0042254)2.71639547
143positive regulation of histone deacetylation (GO:0031065)2.70943535
144telomere maintenance (GO:0000723)2.70646480
145protein localization to chromosome (GO:0034502)2.70161903
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70024082
147metaphase plate congression (GO:0051310)2.69694634
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69645755
149virion assembly (GO:0019068)2.69584205
150regulation of double-strand break repair (GO:2000779)2.69173264
151spindle assembly checkpoint (GO:0071173)2.68773404
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67824227
153DNA replication (GO:0006260)2.67771992
154mitotic spindle assembly checkpoint (GO:0007094)2.67652575
155regulation of cell cycle checkpoint (GO:1901976)2.67137005
156NADPH regeneration (GO:0006740)2.65841487
157adenosine receptor signaling pathway (GO:0001973)2.65628168
158platelet aggregation (GO:0070527)2.63823632
1593-UTR-mediated mRNA stabilization (GO:0070935)2.62168448
160pyrimidine nucleoside salvage (GO:0043097)2.61612477
161pyrimidine-containing compound salvage (GO:0008655)2.61612477
162negative regulation of viral release from host cell (GO:1902187)2.56059125
163positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.47637345
164regulation of regulated secretory pathway (GO:1903305)2.47070432
165protein targeting to plasma membrane (GO:0072661)2.46773348
166hypotonic response (GO:0006971)2.45882667
167regulation of T-helper 2 cell differentiation (GO:0045628)2.45856222
168adherens junction assembly (GO:0034333)2.45269534
169peptidyl-arginine omega-N-methylation (GO:0035247)2.44357698
170negative regulation of homotypic cell-cell adhesion (GO:0034111)2.43612866
171apoptotic process involved in morphogenesis (GO:0060561)2.43200505
172leukocyte aggregation (GO:0070486)2.41189329
173cellular response to virus (GO:0098586)2.38041003
174focal adhesion assembly (GO:0048041)2.36486009
175cell-substrate adherens junction assembly (GO:0007045)2.36486009
176negative regulation of stress fiber assembly (GO:0051497)2.36431044
177activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35418889
178response to peptidoglycan (GO:0032494)2.33295455
179actin filament polymerization (GO:0030041)2.33123383
180regulation of mast cell activation involved in immune response (GO:0033006)2.32687845
181basement membrane organization (GO:0071711)2.32643953
182positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.32375887
183NIK/NF-kappaB signaling (GO:0038061)2.30175736
184amyloid precursor protein metabolic process (GO:0042982)2.26526850
185endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.25474438
186neutrophil activation (GO:0042119)2.24954977
187positive regulation of nuclease activity (GO:0032075)2.24839716
188UV protection (GO:0009650)2.23683310
189granulocyte activation (GO:0036230)2.23515728
190fibril organization (GO:0097435)2.20000834
191retrograde transport, endosome to Golgi (GO:0042147)2.19219865
192positive regulation of extracellular matrix organization (GO:1903055)2.18726400
193modification by symbiont of host morphology or physiology (GO:0044003)2.17750021
194adenine nucleotide transport (GO:0051503)2.17659226
195macrophage activation involved in immune response (GO:0002281)2.17577486
196viral protein processing (GO:0019082)2.17546424
197leukocyte migration involved in inflammatory response (GO:0002523)2.17451138
198regulation of protein dephosphorylation (GO:0035304)2.17060761
199negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.16322348
200response to host defenses (GO:0052200)2.16295295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67413648
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.75450713
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.55343200
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.36202501
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23465432
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00555868
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85856578
8LXR_22292898_ChIP-Seq_THP-1_Human2.85746913
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80591629
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79031875
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76419507
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69279339
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65002167
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64187909
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.60625390
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.52953546
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51861683
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46852027
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45878661
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.38161525
21XRN2_22483619_ChIP-Seq_HELA_Human2.32874429
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29068117
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24665749
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23326226
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18212971
26RACK7_27058665_Chip-Seq_MCF-7_Human2.15373581
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14915620
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03856467
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02581443
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.99206609
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.95105012
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94782951
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92640760
34MYC_22102868_ChIP-Seq_BL_Human1.91879423
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89918934
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89710781
37KDM2B_26808549_Chip-Seq_DND41_Human1.88031687
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86399635
39TCF7_22412390_ChIP-Seq_EML_Mouse1.83070033
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82132722
41P68_20966046_ChIP-Seq_HELA_Human1.78699541
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77488854
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76672215
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75494838
45GABP_19822575_ChIP-Seq_HepG2_Human1.73998674
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.73998345
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70950249
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.70836989
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70013336
50TTF2_22483619_ChIP-Seq_HELA_Human1.69931571
51VDR_24763502_ChIP-Seq_THP-1_Human1.68788090
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.67346275
53VDR_23849224_ChIP-Seq_CD4+_Human1.66501638
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.65519492
55DCP1A_22483619_ChIP-Seq_HELA_Human1.62538699
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.61415793
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60804844
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.60581845
59SMC4_20622854_ChIP-Seq_HELA_Human1.53572903
60MAF_26560356_Chip-Seq_TH1_Human1.53292134
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.52970401
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51972238
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51814280
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.51274149
65UTX_26944678_Chip-Seq_JUKART_Human1.50843597
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50698891
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50106755
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49331606
69AR_21909140_ChIP-Seq_LNCAP_Human1.48480143
70BCOR_27268052_Chip-Seq_Bcells_Human1.48451091
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48366250
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48326130
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.48290102
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48121496
75CIITA_25753668_ChIP-Seq_RAJI_Human1.48054063
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47676985
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46632681
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46240642
79KDM2B_26808549_Chip-Seq_K562_Human1.44514651
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44495386
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43886239
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43712804
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43706141
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42842484
85ZNF263_19887448_ChIP-Seq_K562_Human1.42804857
86BCL6_27268052_Chip-Seq_Bcells_Human1.42463798
87TFEB_21752829_ChIP-Seq_HELA_Human1.42345841
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42048212
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41603928
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40242410
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39503607
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39246773
93MAF_26560356_Chip-Seq_TH2_Human1.38960229
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38030001
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.37597233
96KDM5A_27292631_Chip-Seq_BREAST_Human1.37445181
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37238614
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35774720
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.35321377
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34322854
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33874636
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33857146
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33184619
104NCOR1_26117541_ChIP-Seq_K562_Human1.32910893
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32824797
106VDR_21846776_ChIP-Seq_THP-1_Human1.31909852
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31301859
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.31112131
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31037224
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30189045
111KDM2B_26808549_Chip-Seq_JURKAT_Human1.27139114
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26856859
113BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26064977
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25900963
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24174172
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23936976
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23210403
118SPI1_23127762_ChIP-Seq_K562_Human1.23011172
119ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22959851
120CTCF_26484167_Chip-Seq_Bcells_Mouse1.21914401
121CREB1_26743006_Chip-Seq_LNCaP_Human1.21711959
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21502778
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20508622
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19776438
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19489616
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18945020
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18395014
128TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17895078
129TP53_22127205_ChIP-Seq_IMR90_Human1.16992304
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14501620
131PHF8_20622854_ChIP-Seq_HELA_Human1.13970990
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13833270
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13210541
134NANOG_21062744_ChIP-ChIP_HESCs_Human1.12673097
135SRF_21415370_ChIP-Seq_HL-1_Mouse1.12646952
136ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11738108
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11373241
138P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11298110
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11181012
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10777795
141GATA1_19941826_ChIP-Seq_K562_Human1.10334113
142RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10117979
143CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09532649
144E2F1_20622854_ChIP-Seq_HELA_Human1.08686300
145NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08168674
146NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07497840
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07399377
148KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07385106
149KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07385106
150KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07385106
151PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07357629
152CTCF_21964334_Chip-Seq_Bcells_Human1.07196067
153PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07046849
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05861809
155SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05287241
156STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05266488
157SA1_27219007_Chip-Seq_Bcells_Human1.04621578
158SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04582328
159PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04312557
160* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03300000
161ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03212742
162ATF3_27146783_Chip-Seq_COLON_Human1.01962738
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01381219
164TP63_22573176_ChIP-Seq_HFKS_Human1.00584078
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98672198
166CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98174458
167* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98143441
168NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96032151
169TP63_19390658_ChIP-ChIP_HaCaT_Human0.95425412
170HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94805457
171* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92766536
172ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91927667
173CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91694946
174NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91691991
175ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91017208
176CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90980345
177CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90757325
178PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90418614
179TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90187857
180NOTCH1_21737748_ChIP-Seq_TLL_Human0.90159385
181TET1_21451524_ChIP-Seq_MESCs_Mouse0.90075694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57433014
2MP0010094_abnormal_chromosome_stability4.56048214
3MP0003111_abnormal_nucleus_morphology4.33930350
4MP0003705_abnormal_hypodermis_morpholog4.23712174
5MP0008057_abnormal_DNA_replication3.83384470
6MP0005058_abnormal_lysosome_morphology3.76253610
7MP0003077_abnormal_cell_cycle3.73437381
8MP0003123_paternal_imprinting3.60597849
9MP0004957_abnormal_blastocyst_morpholog3.49939719
10MP0005451_abnormal_body_composition3.28825654
11MP0008058_abnormal_DNA_repair3.17739212
12MP0008007_abnormal_cellular_replicative2.99826602
13MP0004858_abnormal_nervous_system2.90983796
14MP0005464_abnormal_platelet_physiology2.86806710
15MP0001730_embryonic_growth_arrest2.73586786
16MP0008932_abnormal_embryonic_tissue2.68553057
17MP0009840_abnormal_foam_cell2.67651501
18MP0008260_abnormal_autophagy2.66349231
19MP0008438_abnormal_cutaneous_collagen2.45797366
20MP0002653_abnormal_ependyma_morphology2.45576862
21MP0003436_decreased_susceptibility_to2.44230613
22MP0010030_abnormal_orbit_morphology1.96698802
23MP0000350_abnormal_cell_proliferation1.96389637
24MP0003191_abnormal_cellular_cholesterol1.95062715
25MP0003172_abnormal_lysosome_physiology1.94644040
26MP0003303_peritoneal_inflammation1.87031269
27MP0004133_heterotaxia1.86652937
28MP0006292_abnormal_olfactory_placode1.82398116
29MP0004808_abnormal_hematopoietic_stem1.77944850
30MP0001697_abnormal_embryo_size1.71968032
31MP0005410_abnormal_fertilization1.71207956
32MP0002210_abnormal_sex_determination1.70971527
33MP0002085_abnormal_embryonic_tissue1.68240938
34MP0002396_abnormal_hematopoietic_system1.68142103
35MP0003121_genomic_imprinting1.67264755
36MP0002877_abnormal_melanocyte_morpholog1.66722450
37MP0001958_emphysema1.63436990
38MP0000490_abnormal_crypts_of1.61236103
39MP0003300_gastrointestinal_ulcer1.60329583
40MP0002419_abnormal_innate_immunity1.59857634
41MP0001293_anophthalmia1.59337431
42MP0008877_abnormal_DNA_methylation1.56816097
43MP0002080_prenatal_lethality1.56682027
44MP0005397_hematopoietic_system_phenotyp1.56238139
45MP0001545_abnormal_hematopoietic_system1.56238139
46MP0001145_abnormal_male_reproductive1.54439989
47MP0005025_abnormal_response_to1.53296716
48MP0000313_abnormal_cell_death1.51686521
49MP0005257_abnormal_intraocular_pressure1.51665660
50MP0009384_cardiac_valve_regurgitation1.50785718
51MP0003279_aneurysm1.48987738
52MP0004233_abnormal_muscle_weight1.48450105
53MP0001929_abnormal_gametogenesis1.47791167
54MP0003119_abnormal_digestive_system1.46777907
55MP0006082_CNS_inflammation1.45977445
56MP0002084_abnormal_developmental_patter1.45348701
57MP0004185_abnormal_adipocyte_glucose1.45260942
58MP0005380_embryogenesis_phenotype1.44791949
59MP0001672_abnormal_embryogenesis/_devel1.44791949
60MP0001835_abnormal_antigen_presentation1.42923802
61MP0003075_altered_response_to1.41301541
62MP0001533_abnormal_skeleton_physiology1.39973675
63MP0010307_abnormal_tumor_latency1.38488283
64MP0004947_skin_inflammation1.36999101
65MP0003329_amyloid_beta_deposits1.35930007
66MP0003786_premature_aging1.34549421
67MP0004197_abnormal_fetal_growth/weight/1.29062368
68MP0000653_abnormal_sex_gland1.28096572
69MP0000685_abnormal_immune_system1.28056901
70MP0003984_embryonic_growth_retardation1.27445825
71MP0002086_abnormal_extraembryonic_tissu1.26700145
72MP0000343_altered_response_to1.25500200
73MP0005083_abnormal_biliary_tract1.25196016
74MP0002088_abnormal_embryonic_growth/wei1.24807185
75MP0002019_abnormal_tumor_incidence1.24645626
76MP0005076_abnormal_cell_differentiation1.21625417
77MP0005000_abnormal_immune_tolerance1.20714190
78MP0002132_abnormal_respiratory_system1.20616863
79MP0003698_abnormal_male_reproductive1.18835308
80MP0001849_ear_inflammation1.18339717
81MP0009333_abnormal_splenocyte_physiolog1.17411479
82MP0003890_abnormal_embryonic-extraembry1.17297755
83MP0005409_darkened_coat_color1.16520838
84MP0003718_maternal_effect1.16309132
85MP0004510_myositis1.16176191
86MP0010352_gastrointestinal_tract_polyps1.14642671
87MP0002998_abnormal_bone_remodeling1.13676898
88MP0000703_abnormal_thymus_morphology1.13674102
89MP0005075_abnormal_melanosome_morpholog1.13582805
90MP0009053_abnormal_anal_canal1.12346007
91MP0003724_increased_susceptibility_to1.11014803
92MP0003091_abnormal_cell_migration1.09731053
93MP0002420_abnormal_adaptive_immunity1.09018642
94MP0001873_stomach_inflammation1.08598898
95MP0001188_hyperpigmentation1.07804102
96MP0000049_abnormal_middle_ear1.07413358
97MP0001819_abnormal_immune_cell1.07412238
98MP0000537_abnormal_urethra_morphology1.07295519
99MP0002723_abnormal_immune_serum1.06994179
100MP0000681_abnormal_thyroid_gland1.06206943
101MP0003183_abnormal_peptide_metabolism1.05277465
102MP0002452_abnormal_antigen_presenting1.04997463
103MP0010155_abnormal_intestine_physiology1.04039709
104MP0009379_abnormal_foot_pigmentation1.03677838
105MP0000747_muscle_weakness1.02595671
106MP0009278_abnormal_bone_marrow1.00653104
107MP0000516_abnormal_urinary_system1.00541724
108MP0005367_renal/urinary_system_phenotyp1.00541724
109MP0005023_abnormal_wound_healing0.99769628
110MP0001348_abnormal_lacrimal_gland0.99719248
111MP0003567_abnormal_fetal_cardiomyocyte0.99221942
112MP0008874_decreased_physiological_sensi0.98898491
113MP0000751_myopathy0.98346068
114MP0000604_amyloidosis0.97562476
115MP0003763_abnormal_thymus_physiology0.96513317
116MP0003315_abnormal_perineum_morphology0.95217616
117MP0002398_abnormal_bone_marrow0.94601028
118MP0005390_skeleton_phenotype0.93999625
119MP0005623_abnormal_meninges_morphology0.93570687
120MP0003806_abnormal_nucleotide_metabolis0.93495264
121MP0000858_altered_metastatic_potential0.91307241
122MP0002161_abnormal_fertility/fecundity0.89629033
123MP0001790_abnormal_immune_system0.89622433
124MP0005387_immune_system_phenotype0.89622433
125MP0000678_abnormal_parathyroid_gland0.87886992
126MP0001800_abnormal_humoral_immune0.87774858
127MP0005501_abnormal_skin_physiology0.87439909
128MP0000003_abnormal_adipose_tissue0.87418303
129MP0002148_abnormal_hypersensitivity_rea0.86437253
130MP0002089_abnormal_postnatal_growth/wei0.86053053
131MP0003221_abnormal_cardiomyocyte_apopto0.84453426
132MP0000759_abnormal_skeletal_muscle0.84410944
133MP0001845_abnormal_inflammatory_respons0.84224522
134MP0005166_decreased_susceptibility_to0.83396199
135MP0000716_abnormal_immune_system0.83146834
136MP0000767_abnormal_smooth_muscle0.82944673
137MP0003448_altered_tumor_morphology0.82653945
138MP0004264_abnormal_extraembryonic_tissu0.82135686
139MP0004883_abnormal_blood_vessel0.82075540
140MP0003453_abnormal_keratinocyte_physiol0.81647122
141MP0000733_abnormal_muscle_development0.81563000
142MP0008469_abnormal_protein_level0.80556507
143MP0003861_abnormal_nervous_system0.80243645
144MP0003795_abnormal_bone_structure0.79902601
145MP0000689_abnormal_spleen_morphology0.79783354
146MP0002722_abnormal_immune_system0.79325934
147MP0003866_abnormal_defecation0.78440821
148MP0001663_abnormal_digestive_system0.78394405
149MP0003283_abnormal_digestive_organ0.76975111
150MP0000428_abnormal_craniofacial_morphol0.75419051
151MP0003828_pulmonary_edema0.75108750
152MP0001542_abnormal_bone_strength0.74204824
153MP0002896_abnormal_bone_mineralization0.73982235
154MP0003656_abnormal_erythrocyte_physiolo0.73737770
155MP0000249_abnormal_blood_vessel0.72937362
156MP0001661_extended_life_span0.72778961
157MP0004130_abnormal_muscle_cell0.72250653
158MP0002060_abnormal_skin_morphology0.72120005
159MP0002751_abnormal_autonomic_nervous0.71372008
160MP0002269_muscular_atrophy0.70387279
161MP0002429_abnormal_blood_cell0.70078576
162MP0000015_abnormal_ear_pigmentation0.69535276
163MP0001119_abnormal_female_reproductive0.68838438
164MP0005621_abnormal_cell_physiology0.68357723
165MP0002092_abnormal_eye_morphology0.66552009
166MP0002249_abnormal_larynx_morphology0.65651192
167MP0005384_cellular_phenotype0.65188053
168MP0003136_yellow_coat_color0.62158807
169MP0002111_abnormal_tail_morphology0.60534042
170MP0003937_abnormal_limbs/digits/tail_de0.60016744
171MP0000750_abnormal_muscle_regeneration0.59365543
172MP0002127_abnormal_cardiovascular_syste0.59070630
173MP0009672_abnormal_birth_weight0.58314110
174MP0002925_abnormal_cardiovascular_devel0.57658583
175MP0003566_abnormal_cell_adhesion0.57526148
176MP0001727_abnormal_embryo_implantation0.57457068
177MP0000477_abnormal_intestine_morphology0.57307322
178MP0003122_maternal_imprinting0.55407134
179MP0005174_abnormal_tail_pigmentation0.55397096
180MP0001919_abnormal_reproductive_system0.54878928

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.87254981
2Birth length less than 3rd percentile (HP:0003561)5.11794371
3Medulloblastoma (HP:0002885)4.34530326
4Abnormality of the astrocytes (HP:0100707)4.01754653
5Astrocytoma (HP:0009592)4.01754653
6Rough bone trabeculation (HP:0100670)3.88264559
7Degeneration of anterior horn cells (HP:0002398)3.66984697
8Abnormality of the anterior horn cell (HP:0006802)3.66984697
9Patellar aplasia (HP:0006443)3.65820987
10Breast hypoplasia (HP:0003187)3.50030030
11Distal lower limb muscle weakness (HP:0009053)3.43785888
12Glioma (HP:0009733)3.40733605
13Nasal polyposis (HP:0100582)3.38572880
14Aplasia/Hypoplasia of the patella (HP:0006498)3.36498210
15Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27982503
16Neoplasm of striated muscle (HP:0009728)3.26477096
17Premature rupture of membranes (HP:0001788)3.24875185
18Vertebral compression fractures (HP:0002953)3.24309461
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19257929
20Premature graying of hair (HP:0002216)3.19007988
21Abnormality of chromosome stability (HP:0003220)3.17470251
22Protrusio acetabuli (HP:0003179)3.16227922
23Selective tooth agenesis (HP:0001592)3.13554079
24Purpura (HP:0000979)3.13392477
25Hyperacusis (HP:0010780)3.07663477
26Abnormality of the nasal mucosa (HP:0000433)3.03643651
27Chromsome breakage (HP:0040012)3.02063228
28Recurrent abscess formation (HP:0002722)2.95795400
29Meckel diverticulum (HP:0002245)2.91184437
30Abnormality of the ileum (HP:0001549)2.89372219
31Reticulocytopenia (HP:0001896)2.88390473
32Rhabdomyosarcoma (HP:0002859)2.88061428
33Cholecystitis (HP:0001082)2.86772748
34Abnormal gallbladder physiology (HP:0012438)2.86772748
35Abnormality of macrophages (HP:0004311)2.84943156
36Aplastic anemia (HP:0001915)2.80703224
37Eczematoid dermatitis (HP:0000976)2.79482306
38Impulsivity (HP:0100710)2.78034591
39Supernumerary spleens (HP:0009799)2.75187686
40Dysostosis multiplex (HP:0000943)2.72347911
41Abnormality of the preputium (HP:0100587)2.72219658
42Petechiae (HP:0000967)2.71321944
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.71050796
44Adenoma sebaceum (HP:0009720)2.70851892
45Angiofibromas (HP:0010615)2.70851892
46Neoplasm of the heart (HP:0100544)2.70449726
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.69224909
48Brushfield spots (HP:0001088)2.67951740
49Tongue fasciculations (HP:0001308)2.67104443
50Bone marrow hypocellularity (HP:0005528)2.61682645
51Cervical subluxation (HP:0003308)2.59991261
52Achilles tendon contracture (HP:0001771)2.59987740
53Premature ovarian failure (HP:0008209)2.54328058
54Cerebral hypomyelination (HP:0006808)2.52488602
55Upper limb amyotrophy (HP:0009129)2.50622539
56Distal upper limb amyotrophy (HP:0007149)2.50622539
57Abnormal trabecular bone morphology (HP:0100671)2.49909642
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.49281783
59Absent thumb (HP:0009777)2.48305524
60Abnormality of the Achilles tendon (HP:0005109)2.48087598
61Disproportionate tall stature (HP:0001519)2.47972615
62Long palpebral fissure (HP:0000637)2.47885511
63Muscle fibrillation (HP:0010546)2.46741779
64Increased connective tissue (HP:0009025)2.45988936
65Carpal bone hypoplasia (HP:0001498)2.44760738
66Neoplasm of the pancreas (HP:0002894)2.42713391
67Hypertensive crisis (HP:0100735)2.41913052
68Prolonged bleeding time (HP:0003010)2.41825262
69Basal cell carcinoma (HP:0002671)2.40207031
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.39945164
71Absent radius (HP:0003974)2.39063271
72Abnormality of the labia minora (HP:0012880)2.34458081
73Thin bony cortex (HP:0002753)2.33790217
74Agnosia (HP:0010524)2.33290049
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33010981
76Horseshoe kidney (HP:0000085)2.29103340
77Gonadotropin excess (HP:0000837)2.28869257
78Tracheoesophageal fistula (HP:0002575)2.28256912
79Absent forearm bone (HP:0003953)2.25779255
80Aplasia involving forearm bones (HP:0009822)2.25779255
81Optic nerve coloboma (HP:0000588)2.25035274
82Heterotopia (HP:0002282)2.24886986
83Trismus (HP:0000211)2.23870848
84Increased variability in muscle fiber diameter (HP:0003557)2.22298770
85Atelectasis (HP:0100750)2.21987292
86Distal lower limb amyotrophy (HP:0008944)2.21377906
87Blue sclerae (HP:0000592)2.21004370
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20659548
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20659548
90Emphysema (HP:0002097)2.19494739
91Recurrent bacterial skin infections (HP:0005406)2.19389378
92Small intestinal stenosis (HP:0012848)2.19257448
93Duodenal stenosis (HP:0100867)2.19257448
94Obstructive lung disease (HP:0006536)2.18803587
95Chronic obstructive pulmonary disease (HP:0006510)2.18803587
96Triphalangeal thumb (HP:0001199)2.18101343
97Abnormality of liposaccharide metabolism (HP:0010968)2.17879145
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.17879145
99Abnormality of glycolipid metabolism (HP:0010969)2.17879145
100Increased cerebral lipofuscin (HP:0011813)2.13523874
101Insomnia (HP:0100785)2.12110303
102Acute lymphatic leukemia (HP:0006721)2.11937597
103Hyperparathyroidism (HP:0000843)2.11349396
104Freckling (HP:0001480)2.11074380
105Abnormality of skeletal muscle fiber size (HP:0012084)2.10824858
106Myelodysplasia (HP:0002863)2.10718199
107Abnormal number of incisors (HP:0011064)2.10712678
108Hyperthyroidism (HP:0000836)2.10531328
109Hand muscle atrophy (HP:0009130)2.08892868
110Mucopolysacchariduria (HP:0008155)2.08746920
111Urinary glycosaminoglycan excretion (HP:0003541)2.08746920
112Neoplasm of the oral cavity (HP:0100649)2.08375749
113Amyloidosis (HP:0011034)2.07923292
114Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07759946
115Abnormality of polysaccharide metabolism (HP:0011012)2.07759946
116Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07759946
117Myopathic facies (HP:0002058)2.06710905
118Stridor (HP:0010307)2.06654702
119Reticulocytosis (HP:0001923)2.06648784
120Flattened epiphyses (HP:0003071)2.06168264
121Recurrent gram-negative bacterial infections (HP:0005420)2.03786120
122Spinal muscular atrophy (HP:0007269)2.03713227
123Hypertriglyceridemia (HP:0002155)2.03493724
124Abnormality of the carotid arteries (HP:0005344)2.03214698
125Chronic otitis media (HP:0000389)2.02361815
126Metaphyseal cupping (HP:0003021)2.01932781
127Menorrhagia (HP:0000132)2.00616287
128Gingivitis (HP:0000230)2.00523781
129Colon cancer (HP:0003003)1.99271145
130Hemorrhage of the eye (HP:0011885)1.98304987
131Death in infancy (HP:0001522)1.96373325
132Cholelithiasis (HP:0001081)1.96342594
133Slender long bone (HP:0003100)1.96022004
134Abnormality of the tricuspid valve (HP:0001702)1.94883511
135Aplasia/hypoplasia of the humerus (HP:0006507)1.93956257
136Menstrual irregularities (HP:0000858)1.93785646
137Spinal rigidity (HP:0003306)1.93276420
138Biconcave vertebral bodies (HP:0004586)1.93058139
139Abnormal platelet volume (HP:0011876)1.92949132
140Secondary amenorrhea (HP:0000869)1.92261358
141Axonal loss (HP:0003447)1.92088506
142Oral leukoplakia (HP:0002745)1.92017678
143Abnormality of the distal phalanges of the toes (HP:0010182)1.91913642
144Ulnar bowing (HP:0003031)1.91836746
145Epistaxis (HP:0000421)1.91415934
146Increased serum ferritin (HP:0003281)1.90865922
147Hypoplasia of the radius (HP:0002984)1.90539987
148Female pseudohermaphroditism (HP:0010458)1.90510741
149Cerebellar dysplasia (HP:0007033)1.90408067
150J-shaped sella turcica (HP:0002680)1.89256564
151Peritonitis (HP:0002586)1.89059393
152Short nail (HP:0001799)1.87878274
153Polycythemia (HP:0001901)1.87759782
154Polygenic inheritance (HP:0010982)1.87238851
155Flat acetabular roof (HP:0003180)1.86956093
156Hypercortisolism (HP:0001578)1.86903380
157Bulbar palsy (HP:0001283)1.86570419
158Abnormality of the duodenum (HP:0002246)1.85926734
159Joint stiffness (HP:0001387)1.85248341
160Gastrointestinal dysmotility (HP:0002579)1.85195043
161Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84646593
162Broad distal phalanx of finger (HP:0009836)1.84349607
163Back pain (HP:0003418)1.84299211
164Generalized amyotrophy (HP:0003700)1.84285027
165Mitral regurgitation (HP:0001653)1.83731577
166Increased neuronal autofluorescent lipopigment (HP:0002074)1.82310571
167Cleft eyelid (HP:0000625)1.82113709
168Cellulitis (HP:0100658)1.82045191
169Broad face (HP:0000283)1.81560828
170Segmental peripheral demyelination/remyelination (HP:0003481)1.81147590
171Cerebral aneurysm (HP:0004944)1.81025471
172Dilatation of the ascending aorta (HP:0005111)1.80700285
173Sloping forehead (HP:0000340)1.80604111
174Coxa vara (HP:0002812)1.78738495
175Cafe-au-lait spot (HP:0000957)1.78668623
176Bladder diverticulum (HP:0000015)1.77464845
177Muscle fiber atrophy (HP:0100295)1.76751658
178Ectopic kidney (HP:0000086)1.74513959
179Chronic bronchitis (HP:0004469)1.73714316
180Breech presentation (HP:0001623)1.73562394
181Malignant neoplasm of the central nervous system (HP:0100836)1.72418624
182Obstructive sleep apnea (HP:0002870)1.72137491
183Elevated erythrocyte sedimentation rate (HP:0003565)1.72106816
184Disinhibition (HP:0000734)1.71903878
185Ureteral duplication (HP:0000073)1.71633442
186Atresia of the external auditory canal (HP:0000413)1.71480410
187Growth hormone excess (HP:0000845)1.71189503
188Increased nuchal translucency (HP:0010880)1.71044035
189Easy fatigability (HP:0003388)1.70524402
190Fragile skin (HP:0001030)1.69716187
191Venous abnormality (HP:0002624)1.68968148
192Difficulty climbing stairs (HP:0003551)1.68604432
193Squamous cell carcinoma (HP:0002860)1.68556320
194Truncus arteriosus (HP:0001660)1.68473764
195Short humerus (HP:0005792)1.67920867
196Severe global developmental delay (HP:0011344)1.67604177
197Clubbing of toes (HP:0100760)1.67497333
198Poor suck (HP:0002033)1.67139830
199Microretrognathia (HP:0000308)1.66680194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.53007733
2TRIB34.98877928
3WEE13.76381610
4ERN13.55089855
5BCKDK3.47072678
6ACVR1B3.21371216
7MAP3K113.15300358
8BUB13.04319583
9EIF2AK32.95710650
10PASK2.89347888
11ARAF2.81257370
12BRSK12.74226215
13PRPF4B2.73137053
14SMG12.66784319
15CDC72.36311434
16MAP3K132.35833591
17STK162.25943780
18PBK2.24015753
19RIPK42.16596515
20TESK22.14583259
21IRAK31.98710451
22NEK21.94389263
23SIK11.88862892
24RPS6KA41.86210005
25MAP2K31.82366237
26PLK11.73054539
27CDK71.71629284
28ICK1.70295127
29PAK41.69767799
30KSR21.67692912
31TGFBR11.65315533
32TTK1.62754679
33TLK11.62011673
34DYRK31.60042243
35MAP3K31.59524234
36TESK11.58057173
37ILK1.53622535
38TSSK61.53063540
39MKNK21.52722291
40CDK121.45745180
41ATR1.38989519
42AURKA1.36493353
43TTN1.34906161
44BMPR1B1.34116751
45BRD41.33122410
46BRSK21.32321070
47PTK61.23719641
48RPS6KB21.22140772
49LRRK21.19902970
50PDPK11.19568154
51MAP3K11.17382923
52PLK41.12759965
53FLT31.12148848
54MKNK11.10156587
55TAOK11.09958329
56CDK41.07627126
57IRAK41.03807201
58CHEK20.98936987
59GRK60.98577129
60NEK10.97428402
61ZAP700.96441325
62CHEK10.95705748
63MAP4K10.95666217
64TNK20.95427114
65FGFR40.94976032
66VRK10.94643047
67DAPK10.94407905
68DYRK20.93116663
69BLK0.92522532
70VRK20.90584401
71MAP2K20.89358920
72JAK30.88703355
73TBK10.86154871
74PNCK0.85391803
75TYK20.85308177
76RAF10.83888221
77AKT30.82795628
78BMX0.82000971
79EPHA20.80185118
80RIPK10.79987106
81AURKB0.79726333
82CAMKK10.79630121
83MARK20.78600579
84MOS0.78120492
85EIF2AK20.77727150
86PDK10.77705507
87UHMK10.77653656
88STK100.77021340
89PRKD30.76198555
90TYRO30.73415456
91MUSK0.72999036
92CDK80.72170102
93CSK0.71402362
94BTK0.71244906
95CDC42BPA0.70399819
96CDK20.70216628
97STK38L0.69122177
98PAK10.69109812
99ATM0.68273681
100SCYL20.68118526
101ALK0.67991291
102KIT0.67731511
103PKN20.65368844
104RPS6KA60.63911597
105STK40.63132830
106RPS6KL10.62699281
107RPS6KC10.62699281
108PRKG20.62159638
109MAPK70.61721295
110IRAK20.61040694
111NME20.60767612
112RET0.59942499
113SRPK10.59525341
114HCK0.59431415
115PDK30.58799886
116PDK40.58799886
117PLK30.58379724
118PTK20.58323256
119MAP3K100.58228786
120MAP3K80.57322941
121PIM20.56948958
122FES0.56467041
123STK380.55177506
124EPHB10.53634770
125MAPK110.53479576
126MAP3K20.53204365
127MAP3K70.52579451
128NTRK10.51758747
129DYRK1B0.51131438
130CSNK2A10.50126052
131LIMK10.48950182
132MAPK120.47478618
133PDGFRA0.47441208
134MAPK150.45794714
135PIM10.44736344
136CSNK2A20.44658374
137LMTK20.44501748
138MYLK0.44069738
139PRKD10.44031580
140MAPKAPK20.43157651
141EPHB20.42982663
142HIPK20.42696150
143PRKD20.41979870
144SIK20.39246453
145PAK60.39011301
146DAPK30.38171566
147RPS6KA10.38066648
148PRKCI0.37980123
149MTOR0.37890222
150RPS6KA50.36670702
151ERBB20.36237234
152MAP2K10.35946209
153CSF1R0.35469182
154EEF2K0.35321710
155CCNB10.35092486
156LATS20.34663842
157SIK30.34411146
158CDK10.33983602
159PAK20.33650819
160PRKCH0.33210709
161FGR0.32852267
162MATK0.30809501
163MAPKAPK30.30019754
164BRAF0.27767453
165TAOK20.27728218
166MELK0.27520350
167RPS6KA20.27065629
168ZAK0.24310792
169CSNK1E0.23019022

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.89698123
2Mismatch repair_Homo sapiens_hsa034304.76178261
3Spliceosome_Homo sapiens_hsa030403.55520700
4Base excision repair_Homo sapiens_hsa034103.37987227
5RNA transport_Homo sapiens_hsa030133.25188648
6Ribosome_Homo sapiens_hsa030102.86157850
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81688137
8Proteasome_Homo sapiens_hsa030502.81375826
9Cell cycle_Homo sapiens_hsa041102.77460772
10Other glycan degradation_Homo sapiens_hsa005112.73452982
11RNA polymerase_Homo sapiens_hsa030202.68244220
12Homologous recombination_Homo sapiens_hsa034402.67091132
13One carbon pool by folate_Homo sapiens_hsa006702.54871508
14Fanconi anemia pathway_Homo sapiens_hsa034602.42332380
15Nucleotide excision repair_Homo sapiens_hsa034202.40607239
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24024247
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09276866
18Basal transcription factors_Homo sapiens_hsa030221.99543970
19Pyrimidine metabolism_Homo sapiens_hsa002401.98439414
20p53 signaling pathway_Homo sapiens_hsa041151.87558138
21mRNA surveillance pathway_Homo sapiens_hsa030151.67051058
22Prion diseases_Homo sapiens_hsa050201.66699626
23Osteoclast differentiation_Homo sapiens_hsa043801.64797732
24RNA degradation_Homo sapiens_hsa030181.55735412
25Lysosome_Homo sapiens_hsa041421.54325048
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51463895
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39551306
28Non-homologous end-joining_Homo sapiens_hsa034501.33008922
29Oocyte meiosis_Homo sapiens_hsa041141.29535003
30Sphingolipid signaling pathway_Homo sapiens_hsa040711.28993133
31Vibrio cholerae infection_Homo sapiens_hsa051101.28871073
32Renal cell carcinoma_Homo sapiens_hsa052111.27196532
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26463253
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25089980
35Endocytosis_Homo sapiens_hsa041441.25055894
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.24011585
37Epstein-Barr virus infection_Homo sapiens_hsa051691.23177906
38Herpes simplex infection_Homo sapiens_hsa051681.21753829
39Purine metabolism_Homo sapiens_hsa002301.17500297
40Leishmaniasis_Homo sapiens_hsa051401.12787856
41Insulin signaling pathway_Homo sapiens_hsa049101.12753676
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08894459
43Platelet activation_Homo sapiens_hsa046111.08814123
44Thyroid cancer_Homo sapiens_hsa052161.07894491
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05160730
46Glioma_Homo sapiens_hsa052141.04096377
47Hepatitis C_Homo sapiens_hsa051601.02882904
48ErbB signaling pathway_Homo sapiens_hsa040121.01653669
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00997251
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99591857
51Phagosome_Homo sapiens_hsa041450.94739686
52Chemokine signaling pathway_Homo sapiens_hsa040620.94454995
53Focal adhesion_Homo sapiens_hsa045100.94238402
54HTLV-I infection_Homo sapiens_hsa051660.93825155
55Choline metabolism in cancer_Homo sapiens_hsa052310.91710973
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91436821
57Antigen processing and presentation_Homo sapiens_hsa046120.90699477
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89889408
59Salmonella infection_Homo sapiens_hsa051320.89601094
60Notch signaling pathway_Homo sapiens_hsa043300.89482359
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.89294079
62Shigellosis_Homo sapiens_hsa051310.88732123
63Tuberculosis_Homo sapiens_hsa051520.88431054
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88427499
65Viral carcinogenesis_Homo sapiens_hsa052030.85037896
66GnRH signaling pathway_Homo sapiens_hsa049120.82626902
67AMPK signaling pathway_Homo sapiens_hsa041520.81179758
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81130805
69Amoebiasis_Homo sapiens_hsa051460.80097468
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79250436
71Bladder cancer_Homo sapiens_hsa052190.78551804
72Synaptic vesicle cycle_Homo sapiens_hsa047210.78543940
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76193174
74T cell receptor signaling pathway_Homo sapiens_hsa046600.75470584
75Colorectal cancer_Homo sapiens_hsa052100.74509994
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.73895921
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73297735
78Vitamin B6 metabolism_Homo sapiens_hsa007500.70150711
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69619696
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68998849
81Basal cell carcinoma_Homo sapiens_hsa052170.68905472
82Prolactin signaling pathway_Homo sapiens_hsa049170.68656443
83Malaria_Homo sapiens_hsa051440.68592874
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68287951
85Apoptosis_Homo sapiens_hsa042100.68236978
86Estrogen signaling pathway_Homo sapiens_hsa049150.67509818
87TNF signaling pathway_Homo sapiens_hsa046680.67251029
88Primary immunodeficiency_Homo sapiens_hsa053400.65053282
89Staphylococcus aureus infection_Homo sapiens_hsa051500.64406090
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64126260
91Toxoplasmosis_Homo sapiens_hsa051450.63663463
92Proteoglycans in cancer_Homo sapiens_hsa052050.63583900
93Legionellosis_Homo sapiens_hsa051340.63389107
94MicroRNAs in cancer_Homo sapiens_hsa052060.62529311
95Acute myeloid leukemia_Homo sapiens_hsa052210.62083176
96Insulin resistance_Homo sapiens_hsa049310.61172956
97Pertussis_Homo sapiens_hsa051330.60839968
98Inositol phosphate metabolism_Homo sapiens_hsa005620.60383278
99Rap1 signaling pathway_Homo sapiens_hsa040150.60331226
100Hedgehog signaling pathway_Homo sapiens_hsa043400.59745686
101Folate biosynthesis_Homo sapiens_hsa007900.59032701
102Measles_Homo sapiens_hsa051620.56967230
103Arginine biosynthesis_Homo sapiens_hsa002200.56659268
104Biosynthesis of amino acids_Homo sapiens_hsa012300.55431059
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55244364
106Carbon metabolism_Homo sapiens_hsa012000.54519958
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53982610
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53447235
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53211386
110Hippo signaling pathway_Homo sapiens_hsa043900.53107520
111Sulfur relay system_Homo sapiens_hsa041220.49860134
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49634013
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47886353
114Fructose and mannose metabolism_Homo sapiens_hsa000510.47493717
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46318053
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.46076747
117Huntingtons disease_Homo sapiens_hsa050160.45460419
118mTOR signaling pathway_Homo sapiens_hsa041500.43853699
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.43659136
120Regulation of autophagy_Homo sapiens_hsa041400.42737224
121Galactose metabolism_Homo sapiens_hsa000520.42136137
122Chronic myeloid leukemia_Homo sapiens_hsa052200.42050654
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41864205
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41770852
125Pathways in cancer_Homo sapiens_hsa052000.40378137
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39381840
127HIF-1 signaling pathway_Homo sapiens_hsa040660.37017635
128Gap junction_Homo sapiens_hsa045400.36544101
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36269785
130Wnt signaling pathway_Homo sapiens_hsa043100.35687661
131VEGF signaling pathway_Homo sapiens_hsa043700.35236486
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.34145433
133Systemic lupus erythematosus_Homo sapiens_hsa053220.33501131
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33429659
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32842493
136Selenocompound metabolism_Homo sapiens_hsa004500.31667693
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31370093
138Hepatitis B_Homo sapiens_hsa051610.31046258
139Pancreatic cancer_Homo sapiens_hsa052120.30792986
140Non-small cell lung cancer_Homo sapiens_hsa052230.30126194
141Small cell lung cancer_Homo sapiens_hsa052220.29140639
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27595970
143Pentose phosphate pathway_Homo sapiens_hsa000300.26835832
144Hematopoietic cell lineage_Homo sapiens_hsa046400.26700070
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.24442605
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23944779
147Influenza A_Homo sapiens_hsa051640.23223463
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22729276
149Endometrial cancer_Homo sapiens_hsa052130.22520456
150B cell receptor signaling pathway_Homo sapiens_hsa046620.22063138
151Melanoma_Homo sapiens_hsa052180.22008785
152Renin-angiotensin system_Homo sapiens_hsa046140.21997022
153Alcoholism_Homo sapiens_hsa050340.21421061
154Viral myocarditis_Homo sapiens_hsa054160.21349143
155Tight junction_Homo sapiens_hsa045300.21232069
156Olfactory transduction_Homo sapiens_hsa047400.20796009
1572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20053972
158Prostate cancer_Homo sapiens_hsa052150.19658252
159Glycosaminoglycan degradation_Homo sapiens_hsa005310.17721435

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