TAF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.70450562
2translational termination (GO:0006415)8.37177617
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.14425138
4translational elongation (GO:0006414)7.05431324
5protein targeting to ER (GO:0045047)7.02967560
6cotranslational protein targeting to membrane (GO:0006613)6.97207296
7ribosomal small subunit biogenesis (GO:0042274)6.80149670
8establishment of protein localization to endoplasmic reticulum (GO:0072599)6.70755546
9protein localization to endoplasmic reticulum (GO:0070972)6.53289672
10viral life cycle (GO:0019058)6.51723819
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.41455424
12cellular protein complex disassembly (GO:0043624)6.39846646
13ribosomal small subunit assembly (GO:0000028)6.24196373
14ribosomal large subunit biogenesis (GO:0042273)6.22048688
15translational initiation (GO:0006413)6.11076408
16protein complex disassembly (GO:0043241)5.60251529
17macromolecular complex disassembly (GO:0032984)5.20852176
18maturation of SSU-rRNA (GO:0030490)5.18598776
19protein targeting to membrane (GO:0006612)4.72186195
20ncRNA 3-end processing (GO:0043628)4.51625318
21folic acid-containing compound biosynthetic process (GO:0009396)4.41737253
22nuclear-transcribed mRNA catabolic process (GO:0000956)4.37621919
23negative regulation of erythrocyte differentiation (GO:0045647)4.34024002
24mRNA catabolic process (GO:0006402)4.16679219
25translation (GO:0006412)4.06660243
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.01104150
27negative regulation of cell killing (GO:0031342)4.01104150
28DNA deamination (GO:0045006)3.97094509
29ribonucleoprotein complex biogenesis (GO:0022613)3.94521617
30RNA catabolic process (GO:0006401)3.94023568
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88135010
32neutrophil activation involved in immune response (GO:0002283)3.87581334
33response to peptidoglycan (GO:0032494)3.87459012
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86197343
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86197343
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.86197343
37modulation by symbiont of host immune response (GO:0052553)3.86197343
38positive regulation by symbiont of host defense response (GO:0052509)3.86197343
39modulation by symbiont of host defense response (GO:0052031)3.86197343
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.65600105
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.64672075
42positive regulation of gamma-delta T cell activation (GO:0046645)3.63556379
43nuclear envelope reassembly (GO:0031468)3.60235144
44mitotic nuclear envelope reassembly (GO:0007084)3.60235144
45pteridine-containing compound biosynthetic process (GO:0042559)3.58361277
46adenosine receptor signaling pathway (GO:0001973)3.58173943
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34292704
48modulation by virus of host process (GO:0019054)3.31511552
49negative regulation of RNA splicing (GO:0033119)3.26882356
50lipoxygenase pathway (GO:0019372)3.23298363
51mannose metabolic process (GO:0006013)3.20767341
52tooth mineralization (GO:0034505)3.19205104
53DNA replication checkpoint (GO:0000076)3.14324447
54detection of bacterium (GO:0016045)3.13648361
55macrophage activation involved in immune response (GO:0002281)3.13630455
56tolerance induction (GO:0002507)3.11374447
57DNA strand elongation involved in DNA replication (GO:0006271)3.11352762
58modulation by symbiont of host cellular process (GO:0044068)3.10701465
59detection of other organism (GO:0098543)3.09316051
60rRNA processing (GO:0006364)3.09251885
61telomere maintenance via semi-conservative replication (GO:0032201)3.06371154
62establishment of protein localization to membrane (GO:0090150)3.04920597
63regulation of interferon-beta biosynthetic process (GO:0045357)3.03049384
64leukocyte aggregation (GO:0070486)3.02905169
65regulation of mast cell degranulation (GO:0043304)3.02536795
66GDP-mannose metabolic process (GO:0019673)3.01252709
67heme biosynthetic process (GO:0006783)3.00075266
68immunoglobulin mediated immune response (GO:0016064)2.99988311
69regulation of apoptotic process involved in morphogenesis (GO:1902337)2.98695266
70spliceosomal snRNP assembly (GO:0000387)2.98203730
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98019553
72rRNA metabolic process (GO:0016072)2.97998951
73tetrahydrofolate metabolic process (GO:0046653)2.97108769
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96214590
75glycine metabolic process (GO:0006544)2.94861799
76positive regulation of T cell apoptotic process (GO:0070234)2.92076179
77maternal placenta development (GO:0001893)2.92011300
78DNA strand elongation (GO:0022616)2.90222376
79protein targeting (GO:0006605)2.87328017
80response to muramyl dipeptide (GO:0032495)2.86200147
81establishment of protein localization to organelle (GO:0072594)2.86166381
82negative regulation of interleukin-12 production (GO:0032695)2.84783018
83regulation of T-helper 2 cell differentiation (GO:0045628)2.84554135
84DNA replication initiation (GO:0006270)2.81193413
85regulation of early endosome to late endosome transport (GO:2000641)2.79786192
86spliceosomal complex assembly (GO:0000245)2.79688783
87cellular component biogenesis (GO:0044085)2.77302026
88lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76203147
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76096143
90response to host immune response (GO:0052572)2.76096143
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76069814
92regulation of leukocyte degranulation (GO:0043300)2.76027084
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75587740
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75578875
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75578875
96regulation of protein heterodimerization activity (GO:0043497)2.75154224
97mature B cell differentiation involved in immune response (GO:0002313)2.73998839
98positive regulation of mast cell activation (GO:0033005)2.72986604
99UV protection (GO:0009650)2.72036640
100regulation of mitotic spindle organization (GO:0060236)2.71751765
101positive regulation of lymphocyte apoptotic process (GO:0070230)2.70507992
1023-UTR-mediated mRNA stabilization (GO:0070935)2.70407969
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69788753
104response to host (GO:0075136)2.69788753
105response to host defenses (GO:0052200)2.69788753
106positive regulation of Cdc42 GTPase activity (GO:0043089)2.69634460
107positive regulation of histone deacetylation (GO:0031065)2.69090151
108protein localization to chromosome, centromeric region (GO:0071459)2.67022860
109cellular response to virus (GO:0098586)2.66903563
110skin morphogenesis (GO:0043589)2.64105853
111NIK/NF-kappaB signaling (GO:0038061)2.63197428
112regulation of gamma-delta T cell activation (GO:0046643)2.62307621
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.61644973
114detection of external biotic stimulus (GO:0098581)2.61194860
115antigen processing and presentation via MHC class Ib (GO:0002475)2.60970813
116myeloid cell activation involved in immune response (GO:0002275)2.60535097
117negative regulation of phagocytosis (GO:0050765)2.60267309
118apoptotic process involved in morphogenesis (GO:0060561)2.59977577
119peptidyl-arginine omega-N-methylation (GO:0035247)2.58596804
120regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58583847
121telomere maintenance via recombination (GO:0000722)2.57348448
122negative regulation of tumor necrosis factor production (GO:0032720)2.56090447
123L-serine metabolic process (GO:0006563)2.55701639
124defense response to protozoan (GO:0042832)2.55609643
125negative regulation of mRNA processing (GO:0050686)2.55222836
126regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.55032842
127regulation of mast cell activation involved in immune response (GO:0033006)2.54425115
128negative regulation of innate immune response (GO:0045824)2.54403469
129positive thymic T cell selection (GO:0045059)2.54137655
130detection of biotic stimulus (GO:0009595)2.53241393
131positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.52566505
132regulation of cell aging (GO:0090342)2.51344781
133regulation of B cell receptor signaling pathway (GO:0050855)2.51110497
134protoporphyrinogen IX metabolic process (GO:0046501)2.50014290
135pentose-phosphate shunt (GO:0006098)2.49967199
136negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.49328828
137serine family amino acid biosynthetic process (GO:0009070)2.48682547
138regulation of tumor necrosis factor production (GO:0032680)2.48530410
139G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.48525766
140myeloid dendritic cell differentiation (GO:0043011)2.48106387
141barbed-end actin filament capping (GO:0051016)2.47688900
142amino sugar catabolic process (GO:0046348)2.46920735
143DNA unwinding involved in DNA replication (GO:0006268)2.46494519
144mitotic nuclear envelope disassembly (GO:0007077)2.45585625
145respiratory burst (GO:0045730)2.44955473
146regulation of necrotic cell death (GO:0010939)2.44786361
147mitotic recombination (GO:0006312)2.44502517
148negative regulation of interleukin-6 production (GO:0032715)2.44315970
149response to protozoan (GO:0001562)2.43717500
150regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43384796
151actin nucleation (GO:0045010)2.43287405
152protein localization to kinetochore (GO:0034501)2.43274441
153antigen processing and presentation of endogenous antigen (GO:0019883)2.40541091
154folic acid-containing compound metabolic process (GO:0006760)2.37298018
155cellular component disassembly (GO:0022411)2.36761989
156RNA stabilization (GO:0043489)2.35822127
157mRNA stabilization (GO:0048255)2.35822127
158pattern specification involved in kidney development (GO:0061004)2.32077557
159intra-S DNA damage checkpoint (GO:0031573)2.31154714
160heme metabolic process (GO:0042168)2.30926500
161pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.30518911
162activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.30310915
163regulation of spindle organization (GO:0090224)2.29171174
164termination of RNA polymerase II transcription (GO:0006369)2.28900104
165pteridine-containing compound metabolic process (GO:0042558)2.28244698
166regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.27498656
167negative regulation of cell aging (GO:0090344)2.27083451
168endothelium development (GO:0003158)2.24996854
169telomere maintenance via telomere lengthening (GO:0010833)2.23332091
170folic acid metabolic process (GO:0046655)2.22432208
171protein localization to membrane (GO:0072657)2.22191143
172negative regulation of mRNA metabolic process (GO:1903312)2.22005652
173DNA replication-dependent nucleosome assembly (GO:0006335)2.20605045
174DNA replication-dependent nucleosome organization (GO:0034723)2.20605045
175nuclear envelope disassembly (GO:0051081)2.20151537
176membrane disassembly (GO:0030397)2.20151537
177pentose metabolic process (GO:0019321)2.18067645
178DNA damage response, detection of DNA damage (GO:0042769)2.17155402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.38354275
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71697292
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67130838
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.35832230
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76367289
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71203558
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57242259
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42946912
9MYC_22102868_ChIP-Seq_BL_Human2.42315294
10VDR_21846776_ChIP-Seq_THP-1_Human2.41728818
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35195131
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34760000
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27078315
14* XRN2_22483619_ChIP-Seq_HELA_Human2.26143182
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21272324
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.13280977
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06255242
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05551700
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01038462
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99808622
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.98874161
22RACK7_27058665_Chip-Seq_MCF-7_Human1.96951295
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93911071
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93688915
25P68_20966046_ChIP-Seq_HELA_Human1.92696091
26DCP1A_22483619_ChIP-Seq_HELA_Human1.92595749
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89221837
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.86169958
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79245963
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74095931
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.70623843
32BCL6_27268052_Chip-Seq_Bcells_Human1.69949080
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.68188720
34BCOR_27268052_Chip-Seq_Bcells_Human1.67975888
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66463583
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.66014088
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65813960
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.65205405
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.65177711
40TTF2_22483619_ChIP-Seq_HELA_Human1.64147011
41* MAF_26560356_Chip-Seq_TH1_Human1.62547449
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60814905
43VDR_24763502_ChIP-Seq_THP-1_Human1.57229192
44VDR_23849224_ChIP-Seq_CD4+_Human1.54968422
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53339025
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.52022319
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51160314
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49837358
49UTX_26944678_Chip-Seq_JUKART_Human1.49363221
50FOXP3_21729870_ChIP-Seq_TREG_Human1.48391185
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48064211
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47369739
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47034233
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46796508
55* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46470889
56MAF_26560356_Chip-Seq_TH2_Human1.45331456
57ZNF263_19887448_ChIP-Seq_K562_Human1.43394363
58* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42287107
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.40980033
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40624510
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39966625
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39380384
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.37945638
64* KDM2B_26808549_Chip-Seq_JURKAT_Human1.37675117
65TCF7_22412390_ChIP-Seq_EML_Mouse1.37481523
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36531857
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35227834
68GABP_19822575_ChIP-Seq_HepG2_Human1.35200620
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34884706
70KDM2B_26808549_Chip-Seq_K562_Human1.34512985
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34231357
72SMC4_20622854_ChIP-Seq_HELA_Human1.34170193
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34106375
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33964464
75CTCF_21964334_Chip-Seq_Bcells_Human1.33440717
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32880209
77* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32379988
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31612620
79SCL_19346495_ChIP-Seq_HPC-7_Human1.30668314
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29229479
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28653507
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28154808
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28095386
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27678540
85* SPI1_23547873_ChIP-Seq_NB4_Human1.27218825
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.27068892
87E2F1_20622854_ChIP-Seq_HELA_Human1.26901779
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26843151
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26679160
90CTCF_26484167_Chip-Seq_Bcells_Mouse1.25800776
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25522193
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25317245
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24794596
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24691907
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24192028
96PHF8_20622854_ChIP-Seq_HELA_Human1.23795051
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.23716085
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23287606
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22989976
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.22719278
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.22430974
102* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20461064
103* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19963860
104SA1_27219007_Chip-Seq_Bcells_Human1.19594449
105* KDM5A_27292631_Chip-Seq_BREAST_Human1.18714431
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18320044
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18172289
108* CREB1_26743006_Chip-Seq_LNCaP_Human1.17899821
109CTCF_27219007_Chip-Seq_Bcells_Human1.17468241
110MYB_26560356_Chip-Seq_TH1_Human1.16824184
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16441665
112SPI1_23127762_ChIP-Seq_K562_Human1.15281205
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15086330
114STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14815437
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13461269
116YY1_22570637_ChIP-Seq_MALME-3M_Human1.12490927
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12211847
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11945273
119* KDM2B_26808549_Chip-Seq_DND41_Human1.11648946
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11465016
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11458714
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10921782
123LXR_22292898_ChIP-Seq_THP-1_Human1.10872421
124GATA1_19941827_ChIP-Seq_MEL_Mouse1.10802930
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10717385
126MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10476599
127IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10128198
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09929212
129AR_21909140_ChIP-Seq_LNCAP_Human1.09407656
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09273806
131* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09100092
132PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09043869
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.08956805
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07838826
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07433140
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06124176
137HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05630318
138CIITA_25753668_ChIP-Seq_RAJI_Human1.05026988
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04799598
140CTCF_20526341_ChIP-Seq_ESCs_Human1.04214869
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04120014
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03992112
143CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03727412
144DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01870890
145ATF3_27146783_Chip-Seq_COLON_Human1.01708269
146* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01524567
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00113401
148FOXP1_21924763_ChIP-Seq_HESCs_Human1.00062691
149POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99558069
150MYB_26560356_Chip-Seq_TH2_Human0.99418403
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98264844
152NCOR1_26117541_ChIP-Seq_K562_Human0.97712208
153SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97358106
154FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96350465
155GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95275306
156MYC_18940864_ChIP-ChIP_HL60_Human0.93954290
157TFEB_21752829_ChIP-Seq_HELA_Human0.93802453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.90711078
2MP0003303_peritoneal_inflammation4.68917367
3MP0005058_abnormal_lysosome_morphology2.96767576
4MP0005464_abnormal_platelet_physiology2.90459236
5MP0003724_increased_susceptibility_to2.63431095
6MP0004510_myositis2.52587290
7MP0005451_abnormal_body_composition2.47973168
8MP0003693_abnormal_embryo_hatching2.34108477
9MP0004185_abnormal_adipocyte_glucose2.20333001
10MP0003300_gastrointestinal_ulcer2.18762687
11MP0009333_abnormal_splenocyte_physiolog2.10094520
12MP0002139_abnormal_hepatobiliary_system2.03750048
13MP0003705_abnormal_hypodermis_morpholog2.02281748
14MP0003111_abnormal_nucleus_morphology1.94425160
15MP0004858_abnormal_nervous_system1.93934779
16MP0008260_abnormal_autophagy1.92313121
17MP0003436_decreased_susceptibility_to1.92164079
18* MP0004957_abnormal_blastocyst_morpholog1.89641877
19MP0000490_abnormal_crypts_of1.87530739
20MP0003172_abnormal_lysosome_physiology1.85875287
21MP0000678_abnormal_parathyroid_gland1.81894366
22MP0003763_abnormal_thymus_physiology1.72064324
23MP0008007_abnormal_cellular_replicative1.71800567
24MP0002138_abnormal_hepatobiliary_system1.65075425
25MP0003077_abnormal_cell_cycle1.64353109
26MP0000685_abnormal_immune_system1.62580188
27MP0010030_abnormal_orbit_morphology1.62316342
28MP0008004_abnormal_stomach_pH1.59907282
29MP0002877_abnormal_melanocyte_morpholog1.57151498
30MP0003806_abnormal_nucleotide_metabolis1.56464032
31MP0010094_abnormal_chromosome_stability1.56299386
32MP0005083_abnormal_biliary_tract1.54498651
33MP0003828_pulmonary_edema1.51798107
34MP0009053_abnormal_anal_canal1.48839235
35MP0002396_abnormal_hematopoietic_system1.47296039
36MP0006082_CNS_inflammation1.46310470
37MP0001800_abnormal_humoral_immune1.42824032
38MP0003656_abnormal_erythrocyte_physiolo1.37291084
39MP0002398_abnormal_bone_marrow1.36336660
40MP0010155_abnormal_intestine_physiology1.35185749
41MP0000858_altered_metastatic_potential1.35098321
42MP0005666_abnormal_adipose_tissue1.33288490
43MP0005000_abnormal_immune_tolerance1.30606518
44MP0000343_altered_response_to1.28030343
45MP0003879_abnormal_hair_cell1.27789915
46MP0001835_abnormal_antigen_presentation1.26564413
47MP0000689_abnormal_spleen_morphology1.25459353
48MP0002452_abnormal_antigen_presenting1.24313357
49MP0001849_ear_inflammation1.23961613
50MP0005397_hematopoietic_system_phenotyp1.21633981
51MP0001545_abnormal_hematopoietic_system1.21633981
52MP0001663_abnormal_digestive_system1.20992438
53MP0005025_abnormal_response_to1.20672407
54MP0000703_abnormal_thymus_morphology1.20349870
55MP0002722_abnormal_immune_system1.20228897
56MP0005076_abnormal_cell_differentiation1.18942553
57MP0004808_abnormal_hematopoietic_stem1.18160615
58* MP0008932_abnormal_embryonic_tissue1.17232860
59MP0002723_abnormal_immune_serum1.17091264
60MP0002420_abnormal_adaptive_immunity1.16764354
61MP0000350_abnormal_cell_proliferation1.16760919
62MP0005360_urolithiasis1.16440817
63MP0003075_altered_response_to1.15878819
64MP0001819_abnormal_immune_cell1.14870609
65MP0005387_immune_system_phenotype1.14697740
66MP0001790_abnormal_immune_system1.14697740
67MP0002405_respiratory_system_inflammati1.14459673
68MP0002132_abnormal_respiratory_system1.12315599
69MP0002998_abnormal_bone_remodeling1.11596057
70MP0002019_abnormal_tumor_incidence1.11351404
71MP0004130_abnormal_muscle_cell1.10892389
72MP0002166_altered_tumor_susceptibility1.10883048
73MP0002429_abnormal_blood_cell1.10312509
74MP0005257_abnormal_intraocular_pressure1.10305626
75MP0003011_delayed_dark_adaptation1.09943254
76MP0008438_abnormal_cutaneous_collagen1.09499042
77MP0000716_abnormal_immune_system1.08569540
78MP0003941_abnormal_skin_development1.06505428
79MP0002933_joint_inflammation1.06185148
80MP0005174_abnormal_tail_pigmentation1.05631474
81MP0005166_decreased_susceptibility_to1.05495012
82MP0000015_abnormal_ear_pigmentation1.02640023
83MP0003566_abnormal_cell_adhesion1.02393455
84MP0003136_yellow_coat_color1.01772150
85MP0010352_gastrointestinal_tract_polyps1.01058408
86MP0005409_darkened_coat_color1.00698057
87MP0001873_stomach_inflammation0.98179121
88MP0002249_abnormal_larynx_morphology0.96156762
89MP0005671_abnormal_response_to0.95967954
90MP0003453_abnormal_keratinocyte_physiol0.95097616
91MP0001851_eye_inflammation0.93625080
92MP0001730_embryonic_growth_arrest0.93148062
93MP0003866_abnormal_defecation0.92905387
94MP0001845_abnormal_inflammatory_respons0.92905268
95MP0000750_abnormal_muscle_regeneration0.92400170
96MP0001533_abnormal_skeleton_physiology0.91790356
97MP0005381_digestive/alimentary_phenotyp0.91230205
98MP0009785_altered_susceptibility_to0.91128689
99MP0002148_abnormal_hypersensitivity_rea0.89167765
100MP0009278_abnormal_bone_marrow0.89121430
101MP0009764_decreased_sensitivity_to0.89072240
102MP0005310_abnormal_salivary_gland0.88613786
103MP0000313_abnormal_cell_death0.88180766
104* MP0002080_prenatal_lethality0.84578930
105MP0001853_heart_inflammation0.83545325
106MP0009840_abnormal_foam_cell0.83154130
107MP0003091_abnormal_cell_migration0.83050929
108MP0005375_adipose_tissue_phenotype0.82434565
109MP0003448_altered_tumor_morphology0.81221152
110MP0001697_abnormal_embryo_size0.81010911
111MP0003279_aneurysm0.80341770
112MP0003786_premature_aging0.80168770
113MP0000465_gastrointestinal_hemorrhage0.80028157
114MP0005220_abnormal_exocrine_pancreas0.79806690
115MP0000609_abnormal_liver_physiology0.79502823
116MP0003186_abnormal_redox_activity0.79248835
117MP0004381_abnormal_hair_follicle0.77887146
118MP0000681_abnormal_thyroid_gland0.77441820
119MP0009672_abnormal_birth_weight0.77428192
120MP0001542_abnormal_bone_strength0.77393505
121MP0000003_abnormal_adipose_tissue0.76919243
122MP0000477_abnormal_intestine_morphology0.76622381
123MP0008469_abnormal_protein_level0.75751227
124MP0005023_abnormal_wound_healing0.75321224
125MP0002419_abnormal_innate_immunity0.75318442
126MP0010307_abnormal_tumor_latency0.74102494
127MP0005410_abnormal_fertilization0.73851712
128MP0002006_tumorigenesis0.73255613
129MP0002089_abnormal_postnatal_growth/wei0.73166038
130MP0004947_skin_inflammation0.72211180
131* MP0005501_abnormal_skin_physiology0.72125353
132MP0006036_abnormal_mitochondrial_physio0.71789138
133MP0000249_abnormal_blood_vessel0.71363178
134MP0002970_abnormal_white_adipose0.70276453
135MP0008874_decreased_physiological_sensi0.70025991
136MP0001986_abnormal_taste_sensitivity0.68860372
137MP0005390_skeleton_phenotype0.68811084
138MP0003191_abnormal_cellular_cholesterol0.68254894
139MP0000598_abnormal_liver_morphology0.66147923

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.13923392
2Macrocytic anemia (HP:0001972)4.88039673
3Abnormal hemoglobin (HP:0011902)4.75165544
4Abnormality of cells of the erythroid lineage (HP:0012130)4.69998905
5Abnormal number of erythroid precursors (HP:0012131)4.66089436
6Recurrent bacterial skin infections (HP:0005406)4.42350280
7Pallor (HP:0000980)4.23664026
8Aplasia/Hypoplasia of the sacrum (HP:0008517)4.19114336
9Purpura (HP:0000979)4.05032447
10Petechiae (HP:0000967)4.04753844
11Abnormality of macrophages (HP:0004311)3.96304490
12Premature rupture of membranes (HP:0001788)3.92346253
13Concave nail (HP:0001598)3.91543230
14Achilles tendon contracture (HP:0001771)3.87695459
15Abnormality of the Achilles tendon (HP:0005109)3.69267730
16Hypertensive crisis (HP:0100735)3.02985628
17Mediastinal lymphadenopathy (HP:0100721)3.01151988
18Thrombocytosis (HP:0001894)2.97238492
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.95471775
20Abnormality of reticulocytes (HP:0004312)2.93304773
21Protrusio acetabuli (HP:0003179)2.88716510
22Colitis (HP:0002583)2.88628169
23Thin bony cortex (HP:0002753)2.81609678
24Recurrent skin infections (HP:0001581)2.74786378
25Myositis (HP:0100614)2.74011186
26Gastrointestinal infarctions (HP:0005244)2.68301226
27Trismus (HP:0000211)2.67928853
28Emphysema (HP:0002097)2.66143707
29Gastrointestinal stroma tumor (HP:0100723)2.65056342
30Sparse lateral eyebrow (HP:0005338)2.63769310
31Multiple enchondromatosis (HP:0005701)2.63088942
32Myocardial infarction (HP:0001658)2.58547411
33Increased cerebral lipofuscin (HP:0011813)2.56205133
34Progressive muscle weakness (HP:0003323)2.52821508
35Hyperthyroidism (HP:0000836)2.50038199
36Meningitis (HP:0001287)2.47539157
37Increased IgE level (HP:0003212)2.46840913
38Testicular atrophy (HP:0000029)2.46395641
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.44551608
40Recurrent gram-negative bacterial infections (HP:0005420)2.40704336
41Chronic obstructive pulmonary disease (HP:0006510)2.40002112
42Obstructive lung disease (HP:0006536)2.40002112
43Spontaneous hematomas (HP:0007420)2.37864833
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36548807
45Seborrheic dermatitis (HP:0001051)2.31880693
46Stomatitis (HP:0010280)2.30229883
47Gingivitis (HP:0000230)2.29438669
48Menorrhagia (HP:0000132)2.27721147
49Increased muscle lipid content (HP:0009058)2.26546499
50Abnormality of glycolipid metabolism (HP:0010969)2.25192041
51Abnormality of liposaccharide metabolism (HP:0010968)2.25192041
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.25192041
53Dysostosis multiplex (HP:0000943)2.21643174
54Obstructive sleep apnea (HP:0002870)2.19928488
55Increased serum ferritin (HP:0003281)2.19892233
56Bulbar palsy (HP:0001283)2.19752219
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18213932
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18213932
59Congenital, generalized hypertrichosis (HP:0004540)2.16543937
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.16221953
61Truncus arteriosus (HP:0001660)2.16138407
62Hypochromic anemia (HP:0001931)2.15073695
63Abnormality of complement system (HP:0005339)2.14352576
64Polygenic inheritance (HP:0010982)2.13666303
65Secondary amenorrhea (HP:0000869)2.13539570
66Genu recurvatum (HP:0002816)2.12955770
67Increased density of long bones (HP:0006392)2.12833569
68Recurrent cutaneous fungal infections (HP:0011370)2.12561667
69Chronic mucocutaneous candidiasis (HP:0002728)2.12561667
70Hepatosplenomegaly (HP:0001433)2.11812032
71Entropion (HP:0000621)2.11401105
72Elevated erythrocyte sedimentation rate (HP:0003565)2.11219431
73Gingival bleeding (HP:0000225)2.09241526
74Orchitis (HP:0100796)2.08001104
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07889602
76Hypertriglyceridemia (HP:0002155)2.06960664
77Exertional dyspnea (HP:0002875)2.06143710
78Microcytic anemia (HP:0001935)2.05105918
79Pustule (HP:0200039)2.04853523
80Abnormality of T cell physiology (HP:0011840)2.04376765
81Oral leukoplakia (HP:0002745)2.03709752
82Myopathic facies (HP:0002058)2.03174945
83Cerebral aneurysm (HP:0004944)2.02847754
84Eczematoid dermatitis (HP:0000976)2.02311799
85Basal cell carcinoma (HP:0002671)2.02092481
86Hemorrhage of the eye (HP:0011885)2.01815559
87Panhypogammaglobulinemia (HP:0003139)2.01285215
88Verrucae (HP:0200043)2.00707625
89Papilloma (HP:0012740)2.00707625
90Polycythemia (HP:0001901)2.00422733
91Vasculitis (HP:0002633)2.00371873
92Cellulitis (HP:0100658)2.00324434
93Rhabdomyosarcoma (HP:0002859)1.98284405
94Abnormal platelet function (HP:0011869)1.97502419
95Impaired platelet aggregation (HP:0003540)1.97502419
96Depressed nasal ridge (HP:0000457)1.96952740
97Lymphopenia (HP:0001888)1.96565117
98Axonal loss (HP:0003447)1.96046396
99Abnormality of the distal phalanges of the toes (HP:0010182)1.95829213
100Multiple lipomas (HP:0001012)1.95218112
101Joint stiffness (HP:0001387)1.95007239
102Deep palmar crease (HP:0006191)1.94477235
103Reduced subcutaneous adipose tissue (HP:0003758)1.93937675
104Breast hypoplasia (HP:0003187)1.92421991
105Redundant skin (HP:0001582)1.92297732
106Double outlet right ventricle (HP:0001719)1.92217031
107Congenital malformation of the right heart (HP:0011723)1.92217031
108Increased intramyocellular lipid droplets (HP:0012240)1.91983117
109Biconcave vertebral bodies (HP:0004586)1.91895997
110Prolonged bleeding time (HP:0003010)1.91893897
111Hyperphosphaturia (HP:0003109)1.90650701
112Triphalangeal thumb (HP:0001199)1.90381926
113Abnormal platelet volume (HP:0011876)1.89778290
114Malnutrition (HP:0004395)1.89289458
115Abnormality of the nasal mucosa (HP:0000433)1.86138829
116Angiofibromas (HP:0010615)1.86027475
117Adenoma sebaceum (HP:0009720)1.86027475
118Gastrointestinal dysmotility (HP:0002579)1.85140826
119Increased IgM level (HP:0003496)1.85102138
120Nasal polyposis (HP:0100582)1.84164955
121Down-sloping shoulders (HP:0200021)1.83255197
122Woolly hair (HP:0002224)1.82366892
123Unilateral renal agenesis (HP:0000122)1.81783840
124Aplasia/Hypoplasia of the thymus (HP:0010515)1.81168090
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.81111751
126Encephalitis (HP:0002383)1.81070308
127Systemic lupus erythematosus (HP:0002725)1.79058352
128Limb-girdle muscle atrophy (HP:0003797)1.77636712
129Recurrent viral infections (HP:0004429)1.76557624
130Increased mean platelet volume (HP:0011877)1.75907074
131Atelectasis (HP:0100750)1.75835591
132Recurrent fungal infections (HP:0002841)1.75640849
133Migraine (HP:0002076)1.75628841
134Gastrointestinal inflammation (HP:0004386)1.75382557
135Abnormality of T cells (HP:0002843)1.74518588
136Late onset (HP:0003584)1.74430986
137Prolonged neonatal jaundice (HP:0006579)1.74230256
138Porencephaly (HP:0002132)1.74073960
139Vertebral compression fractures (HP:0002953)1.73818764
140Inflammation of the large intestine (HP:0002037)1.73211364
141Large earlobe (HP:0009748)1.73010825
142Recurrent abscess formation (HP:0002722)1.72923531
143Rough bone trabeculation (HP:0100670)1.72726546
144Ragged-red muscle fibers (HP:0003200)1.72424972
145Hypercortisolism (HP:0001578)1.72127003
146Chest pain (HP:0100749)1.71206165
147Abnormal pupillary function (HP:0007686)1.69525335
148Peritonitis (HP:0002586)1.68735452
149Mitral regurgitation (HP:0001653)1.68673032
150Epistaxis (HP:0000421)1.68079190
151Abnormality of iron homeostasis (HP:0011031)1.67741749
152Rectal prolapse (HP:0002035)1.66618283
153Mitral valve prolapse (HP:0001634)1.66370219
154Thick lower lip vermilion (HP:0000179)1.65240095
155Hypoparathyroidism (HP:0000829)1.64594234
156Abnormality of dental color (HP:0011073)1.63959263
157Urticaria (HP:0001025)1.63928090
158Soft skin (HP:0000977)1.61475892
159Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61058541
160Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61054208
161Xanthomatosis (HP:0000991)1.60470784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.60241198
2NME23.67556047
3EIF2AK13.56869350
4PRPF4B2.98897543
5RIPK42.83981102
6TESK22.72528339
7SMG12.71446663
8TRIB32.64465484
9BLK2.58833791
10PKN22.46176453
11NEK92.44532687
12PIM22.34205587
13FES2.24162609
14MAP3K102.18942204
15MAP4K12.15836673
16BUB12.03209597
17ARAF1.98639662
18SIK11.95961017
19TAOK21.87497046
20MAP3K131.79792367
21MAP3K111.59551754
22MKNK21.58936984
23CSK1.58440019
24EEF2K1.50196280
25FLT31.49083608
26MAP3K11.44126855
27DMPK1.42675071
28DYRK1B1.37552819
29ICK1.36044748
30TBK11.33971041
31NEK21.31623668
32DYRK31.28486860
33ERN11.23881347
34WEE11.23262775
35LRRK21.19506700
36ZAP701.18082684
37RPS6KA41.17895641
38STK101.15682843
39PDPK11.14040890
40VRK21.11991738
41IRAK41.10238537
42TNK21.07894300
43MAP3K31.06157574
44MARK21.05911250
45PIM11.04446974
46SCYL21.04060800
47DAPK31.03551670
48BCKDK1.02011105
49CDK71.01137988
50CDK90.99852593
51BRAF0.99707202
52TESK10.99315418
53MAP3K80.99284289
54GRK60.98373100
55CDC70.97907036
56IRAK10.97906191
57MAPK120.93921727
58SRPK10.92544396
59IRAK30.92316152
60MOS0.91006419
61TYK20.90512527
62RPS6KC10.89911155
63RPS6KL10.89911155
64CLK10.89663140
65PAK40.88670721
66CDK60.87852052
67CDK40.87826484
68ALK0.86474499
69CDC42BPA0.86205096
70KSR20.85545421
71ILK0.84665325
72PRKD20.81685761
73BTK0.78792440
74PRKD30.78543129
75TEC0.77824752
76MAPK110.77341577
77MAPK150.76302350
78KDR0.76148216
79RPS6KA60.73932405
80AURKB0.73675601
81PDK10.73492773
82IKBKE0.73125092
83EPHB10.72904482
84IKBKB0.72088298
85NLK0.71818363
86CDK190.71443028
87SIK20.70625622
88FER0.69481910
89LCK0.69374359
90TTK0.68230447
91TAOK10.68070934
92HIPK20.66950752
93MKNK10.66603017
94RPS6KB20.66062853
95JAK30.65014224
96MAP3K140.64097110
97MAP2K20.63030184
98PLK10.62424141
99RPS6KA20.62223856
100FGFR40.61491092
101CDK80.60347270
102AURKA0.60255042
103LYN0.57660396
104STK160.55661732
105STK40.53160663
106JAK20.52316602
107EPHB20.52280168
108NME10.50325986
109LIMK10.49986325
110ABL20.49345009
111HCK0.47607244
112IRAK20.47174449
113STK110.46243091
114MTOR0.45582059
115RPS6KA50.44555142
116MAPK70.43175286
117PTK60.43172865
118PRKG20.42764961
119CSF1R0.42517760
120MELK0.42318437
121MYLK0.41538031
122SIK30.41333525
123EIF2AK30.41050868
124VRK10.40999361
125TXK0.40151730
126CSNK2A20.40028068
127PAK10.39763076
128MAPK40.38310300
129BMX0.38015600
130TGFBR20.36547865
131KIT0.36130989
132MAPKAPK20.35796798
133TTN0.35748332
134MAP2K60.35162330
135CDK120.34138169
136FGR0.34054592
137CSNK2A10.33319912
138MAP2K30.32726814
139CHEK20.32534512
140SYK0.31745207
141MARK30.27146886

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.31858122
2Sulfur relay system_Homo sapiens_hsa041223.36537294
3DNA replication_Homo sapiens_hsa030303.27028408
4One carbon pool by folate_Homo sapiens_hsa006703.00445988
5Spliceosome_Homo sapiens_hsa030402.24813222
6Mismatch repair_Homo sapiens_hsa034302.13268320
7Homologous recombination_Homo sapiens_hsa034402.04072705
8Cyanoamino acid metabolism_Homo sapiens_hsa004601.98192082
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96881946
10Base excision repair_Homo sapiens_hsa034101.92234658
11Notch signaling pathway_Homo sapiens_hsa043301.86065480
12RNA polymerase_Homo sapiens_hsa030201.81296348
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72482102
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66776367
15Allograft rejection_Homo sapiens_hsa053301.65590028
16Graft-versus-host disease_Homo sapiens_hsa053321.64348172
17Protein export_Homo sapiens_hsa030601.63321628
18Pyrimidine metabolism_Homo sapiens_hsa002401.57678337
19Nucleotide excision repair_Homo sapiens_hsa034201.54453694
20Tuberculosis_Homo sapiens_hsa051521.53178852
21Folate biosynthesis_Homo sapiens_hsa007901.52759776
22RNA transport_Homo sapiens_hsa030131.50054025
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49801319
24Autoimmune thyroid disease_Homo sapiens_hsa053201.43174160
25Systemic lupus erythematosus_Homo sapiens_hsa053221.40991581
26Bladder cancer_Homo sapiens_hsa052191.40551365
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.40481232
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39107106
29Primary immunodeficiency_Homo sapiens_hsa053401.39033465
30Cell cycle_Homo sapiens_hsa041101.33758408
31Chemokine signaling pathway_Homo sapiens_hsa040621.21756225
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21192676
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19510168
34Acute myeloid leukemia_Homo sapiens_hsa052211.17368535
35Antigen processing and presentation_Homo sapiens_hsa046121.16286404
36p53 signaling pathway_Homo sapiens_hsa041151.16232201
37Lysosome_Homo sapiens_hsa041421.14156118
38TNF signaling pathway_Homo sapiens_hsa046681.13452514
39Fanconi anemia pathway_Homo sapiens_hsa034601.11956005
40Pentose phosphate pathway_Homo sapiens_hsa000301.11056664
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10384563
42Platelet activation_Homo sapiens_hsa046111.08943596
43* Herpes simplex infection_Homo sapiens_hsa051681.07522392
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.07495478
45mRNA surveillance pathway_Homo sapiens_hsa030151.05274093
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05046270
47Chronic myeloid leukemia_Homo sapiens_hsa052201.02739976
48Fructose and mannose metabolism_Homo sapiens_hsa000511.00830183
49Thyroid cancer_Homo sapiens_hsa052161.00533917
50B cell receptor signaling pathway_Homo sapiens_hsa046620.99228627
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96599629
52Asthma_Homo sapiens_hsa053100.95837908
53Endocytosis_Homo sapiens_hsa041440.94422934
54Selenocompound metabolism_Homo sapiens_hsa004500.94284003
55Galactose metabolism_Homo sapiens_hsa000520.90448133
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89269226
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87924464
58Renal cell carcinoma_Homo sapiens_hsa052110.87721588
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.85938860
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83727028
61Viral carcinogenesis_Homo sapiens_hsa052030.81746237
62Phagosome_Homo sapiens_hsa041450.81611201
63Leishmaniasis_Homo sapiens_hsa051400.81154315
64Measles_Homo sapiens_hsa051620.81146593
65Salmonella infection_Homo sapiens_hsa051320.79694100
66Prion diseases_Homo sapiens_hsa050200.77836518
67Endometrial cancer_Homo sapiens_hsa052130.77744954
68Other glycan degradation_Homo sapiens_hsa005110.77734977
69HTLV-I infection_Homo sapiens_hsa051660.77237964
70mTOR signaling pathway_Homo sapiens_hsa041500.76589436
71Apoptosis_Homo sapiens_hsa042100.76303255
72Shigellosis_Homo sapiens_hsa051310.74494262
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74170224
74Pertussis_Homo sapiens_hsa051330.73426477
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73291739
76Epstein-Barr virus infection_Homo sapiens_hsa051690.72805150
77Type I diabetes mellitus_Homo sapiens_hsa049400.72592669
78Hematopoietic cell lineage_Homo sapiens_hsa046400.72400343
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.70289047
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.70152164
81Rheumatoid arthritis_Homo sapiens_hsa053230.69862830
82Hepatitis B_Homo sapiens_hsa051610.69560541
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66500910
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66492131
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.65651972
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64415305
87Small cell lung cancer_Homo sapiens_hsa052220.64073921
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63960039
89African trypanosomiasis_Homo sapiens_hsa051430.63611816
90Osteoclast differentiation_Homo sapiens_hsa043800.63407985
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63367053
92Prolactin signaling pathway_Homo sapiens_hsa049170.63192655
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62763713
94Legionellosis_Homo sapiens_hsa051340.62480102
95Malaria_Homo sapiens_hsa051440.61839005
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60345044
97Viral myocarditis_Homo sapiens_hsa054160.59505555
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.59439791
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.59061935
100Nitrogen metabolism_Homo sapiens_hsa009100.58961782
101Biosynthesis of amino acids_Homo sapiens_hsa012300.58885629
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.58820179
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58391198
104T cell receptor signaling pathway_Homo sapiens_hsa046600.57727111
105FoxO signaling pathway_Homo sapiens_hsa040680.55824455
106Parkinsons disease_Homo sapiens_hsa050120.55705652
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.54700822
108MAPK signaling pathway_Homo sapiens_hsa040100.54459809
109Proteasome_Homo sapiens_hsa030500.52904795
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52564588
111Glioma_Homo sapiens_hsa052140.51965044
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50668360
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50485726
114Insulin signaling pathway_Homo sapiens_hsa049100.50374495
115Carbon metabolism_Homo sapiens_hsa012000.50229975
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49985911
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49264180
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49238436
119MicroRNAs in cancer_Homo sapiens_hsa052060.49009787
120Lysine degradation_Homo sapiens_hsa003100.48692082
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47648867
122Sulfur metabolism_Homo sapiens_hsa009200.47407317
123Colorectal cancer_Homo sapiens_hsa052100.47202947
124Insulin resistance_Homo sapiens_hsa049310.46233779
125Non-small cell lung cancer_Homo sapiens_hsa052230.45398906
126Glutathione metabolism_Homo sapiens_hsa004800.45047773
127Choline metabolism in cancer_Homo sapiens_hsa052310.44972475
128Pancreatic cancer_Homo sapiens_hsa052120.44763039
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43329717
130VEGF signaling pathway_Homo sapiens_hsa043700.42691281
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42674504
132Staphylococcus aureus infection_Homo sapiens_hsa051500.42186046
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41602819
134RNA degradation_Homo sapiens_hsa030180.41053251
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41007383
136Vitamin B6 metabolism_Homo sapiens_hsa007500.40940408
137Toxoplasmosis_Homo sapiens_hsa051450.39315035
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.37210547
139Tryptophan metabolism_Homo sapiens_hsa003800.36233922
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36045963
141Hepatitis C_Homo sapiens_hsa051600.35897326
142Fatty acid degradation_Homo sapiens_hsa000710.35199011
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.34748473
144Huntingtons disease_Homo sapiens_hsa050160.34292312
145Arginine biosynthesis_Homo sapiens_hsa002200.34223226
146Prostate cancer_Homo sapiens_hsa052150.34163011
147Melanoma_Homo sapiens_hsa052180.34041220
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33779848
149Influenza A_Homo sapiens_hsa051640.33325493
150HIF-1 signaling pathway_Homo sapiens_hsa040660.32604780
151Non-homologous end-joining_Homo sapiens_hsa034500.31693587
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31390078

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