TAF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.93778617
2maturation of SSU-rRNA (GO:0030490)4.75998949
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.56799349
4protein complex biogenesis (GO:0070271)4.27357583
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23961198
6respiratory electron transport chain (GO:0022904)4.22259673
7electron transport chain (GO:0022900)4.17670405
8mitochondrial respiratory chain complex assembly (GO:0033108)4.16982343
9formation of translation preinitiation complex (GO:0001731)4.06085083
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.05302963
11DNA deamination (GO:0045006)4.04480634
127-methylguanosine mRNA capping (GO:0006370)4.01077809
13termination of RNA polymerase III transcription (GO:0006386)3.98944907
14transcription elongation from RNA polymerase III promoter (GO:0006385)3.98944907
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.98463041
16ATP synthesis coupled proton transport (GO:0015986)3.98463041
17chaperone-mediated protein transport (GO:0072321)3.98135784
18RNA capping (GO:0036260)3.96322157
197-methylguanosine RNA capping (GO:0009452)3.96322157
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.95320523
21viral transcription (GO:0019083)3.91289934
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.84539557
23translational termination (GO:0006415)3.84246891
24cullin deneddylation (GO:0010388)3.83375292
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.81887971
26ribosomal small subunit biogenesis (GO:0042274)3.80637873
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.80335062
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.79550131
29protein deneddylation (GO:0000338)3.78137046
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77811371
31negative regulation of ligase activity (GO:0051352)3.77811371
32ribosomal small subunit assembly (GO:0000028)3.74494624
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.68443746
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.68443746
35respiratory chain complex IV assembly (GO:0008535)3.66291884
36DNA strand elongation involved in DNA replication (GO:0006271)3.61568361
37cotranslational protein targeting to membrane (GO:0006613)3.61362820
38chromatin remodeling at centromere (GO:0031055)3.59870657
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58872528
40translational initiation (GO:0006413)3.58369242
41translational elongation (GO:0006414)3.57604511
42protein targeting to ER (GO:0045047)3.55509969
43establishment of integrated proviral latency (GO:0075713)3.53083692
44ribonucleoprotein complex biogenesis (GO:0022613)3.48987137
45translation (GO:0006412)3.48157278
46DNA strand elongation (GO:0022616)3.47240167
47ribosomal large subunit biogenesis (GO:0042273)3.44778430
48DNA unwinding involved in DNA replication (GO:0006268)3.43027068
49guanosine-containing compound biosynthetic process (GO:1901070)3.42345672
50CENP-A containing nucleosome assembly (GO:0034080)3.41667923
51ribosome biogenesis (GO:0042254)3.41065567
52protein localization to endoplasmic reticulum (GO:0070972)3.41009332
53GTP biosynthetic process (GO:0006183)3.39195482
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38827788
55regulation of cellular amino acid metabolic process (GO:0006521)3.38380190
56transcription elongation from RNA polymerase I promoter (GO:0006362)3.38094425
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37163759
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36950102
59DNA replication initiation (GO:0006270)3.36315652
60spliceosomal snRNP assembly (GO:0000387)3.33799799
61replication fork processing (GO:0031297)3.33739795
62rRNA processing (GO:0006364)3.32528083
63transcription-coupled nucleotide-excision repair (GO:0006283)3.32165333
64protein targeting to mitochondrion (GO:0006626)3.29912142
65cytochrome complex assembly (GO:0017004)3.29197160
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29161656
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29161656
68nucleobase biosynthetic process (GO:0046112)3.27633532
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26022754
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26022754
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26022754
72establishment of protein localization to mitochondrion (GO:0072655)3.25690282
73positive regulation of ligase activity (GO:0051351)3.25296947
74peptidyl-histidine modification (GO:0018202)3.24077618
75inner mitochondrial membrane organization (GO:0007007)3.23549544
76purine nucleobase biosynthetic process (GO:0009113)3.23485658
77DNA replication checkpoint (GO:0000076)3.22564265
78cellular protein complex disassembly (GO:0043624)3.22520152
79UTP biosynthetic process (GO:0006228)3.21520641
80ribosome assembly (GO:0042255)3.21419584
81protein neddylation (GO:0045116)3.20702741
82behavioral response to nicotine (GO:0035095)3.20601661
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20443198
84signal transduction involved in DNA damage checkpoint (GO:0072422)3.20443198
85pseudouridine synthesis (GO:0001522)3.20108139
86cellular component biogenesis (GO:0044085)3.19839089
87rRNA metabolic process (GO:0016072)3.19753977
88mitotic metaphase plate congression (GO:0007080)3.18898104
89NADH dehydrogenase complex assembly (GO:0010257)3.17083633
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17083633
91mitochondrial respiratory chain complex I assembly (GO:0032981)3.17083633
92protein-cofactor linkage (GO:0018065)3.16727598
93rRNA modification (GO:0000154)3.16659756
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.16298420
95DNA damage response, detection of DNA damage (GO:0042769)3.15328797
96termination of RNA polymerase I transcription (GO:0006363)3.15063923
97regulation of ubiquitin-protein transferase activity (GO:0051438)3.14916671
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14302176
99L-methionine salvage (GO:0071267)3.14269639
100L-methionine biosynthetic process (GO:0071265)3.14269639
101amino acid salvage (GO:0043102)3.14269639
102viral life cycle (GO:0019058)3.11145512
103transcription from RNA polymerase I promoter (GO:0006360)3.08313304
104viral mRNA export from host cell nucleus (GO:0046784)3.07110008
105* transcription elongation from RNA polymerase II promoter (GO:0006368)3.06716776
106regulation of ligase activity (GO:0051340)3.06061796
107establishment of viral latency (GO:0019043)3.05913441
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02184101
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01729626
110protein localization to mitochondrion (GO:0070585)2.99291729
111negative regulation of DNA-templated transcription, elongation (GO:0032785)2.97676665
112negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.97676665
113protein complex disassembly (GO:0043241)2.96865547
114CTP biosynthetic process (GO:0006241)2.96616007
115CTP metabolic process (GO:0046036)2.96616007
116regulation of mitochondrial translation (GO:0070129)2.96377001
117resolution of meiotic recombination intermediates (GO:0000712)2.95552056
118histone exchange (GO:0043486)2.94295782
119macromolecular complex disassembly (GO:0032984)2.91447737
120nuclear-transcribed mRNA catabolic process (GO:0000956)2.89528052
121rRNA methylation (GO:0031167)2.89110393
122hydrogen ion transmembrane transport (GO:1902600)2.87028300
123organelle disassembly (GO:1903008)2.80627640
124water-soluble vitamin biosynthetic process (GO:0042364)2.77168095
125DNA double-strand break processing (GO:0000729)2.77148752
126platelet dense granule organization (GO:0060155)2.76451098
127intracellular protein transmembrane import (GO:0044743)2.76144085
128spliceosomal complex assembly (GO:0000245)2.74951083
129ATP biosynthetic process (GO:0006754)2.74766413
130purine nucleoside triphosphate biosynthetic process (GO:0009145)2.74505635
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74375014
132mRNA catabolic process (GO:0006402)2.73457250
133purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72446475
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.68617507
135base-excision repair, AP site formation (GO:0006285)2.68573838
136kinetochore assembly (GO:0051382)2.68178792
137anterograde synaptic vesicle transport (GO:0048490)2.64516671
138ubiquinone biosynthetic process (GO:0006744)2.63789437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.48842355
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.42450901
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.17925917
4E2F7_22180533_ChIP-Seq_HELA_Human4.06580932
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.02394909
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.95622733
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.90524814
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67695733
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.66567929
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.62702338
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.60918971
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.49473771
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.21598442
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.02148387
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96108489
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92582463
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91037886
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.83577989
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83054428
20* XRN2_22483619_ChIP-Seq_HELA_Human2.75219275
21* VDR_23849224_ChIP-Seq_CD4+_Human2.66184518
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.65642349
23ZNF274_21170338_ChIP-Seq_K562_Hela2.52846809
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39458809
25GABP_19822575_ChIP-Seq_HepG2_Human2.35461014
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.33927029
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27905992
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27762256
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27025892
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24269085
31TTF2_22483619_ChIP-Seq_HELA_Human2.23998354
32FOXP3_21729870_ChIP-Seq_TREG_Human2.21189640
33VDR_22108803_ChIP-Seq_LS180_Human2.08465965
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.08307562
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08033217
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.01762739
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99720997
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.97929522
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91460697
40FUS_26573619_Chip-Seq_HEK293_Human1.91380809
41EWS_26573619_Chip-Seq_HEK293_Human1.89653611
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86146045
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83087473
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82239762
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.77840662
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77143782
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71812477
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70891120
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67310871
50ELK1_19687146_ChIP-ChIP_HELA_Human1.65074134
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65011157
52IGF1R_20145208_ChIP-Seq_DFB_Human1.61552128
53AR_21909140_ChIP-Seq_LNCAP_Human1.60710480
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57642122
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55636148
56CIITA_25753668_ChIP-Seq_RAJI_Human1.44239924
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43644126
58IRF1_19129219_ChIP-ChIP_H3396_Human1.43546725
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39174138
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37460939
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.37148739
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37047381
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35707597
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33306728
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.30964218
66KDM5A_27292631_Chip-Seq_BREAST_Human1.30401707
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30124530
68* TP63_19390658_ChIP-ChIP_HaCaT_Human1.29088632
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27147699
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24033498
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23083356
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22075571
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21817237
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21265846
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19480117
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18882492
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.18618864
78TAF15_26573619_Chip-Seq_HEK293_Human1.18532403
79MYC_18940864_ChIP-ChIP_HL60_Human1.18281727
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18114318
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16786911
82TP53_22573176_ChIP-Seq_HFKS_Human1.15164699
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14563859
84* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13691165
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11580554
86P300_19829295_ChIP-Seq_ESCs_Human1.11205137
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10790114
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10459800
89* E2F1_21310950_ChIP-Seq_MCF-7_Human1.09873509
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09139626
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08327326
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06503041
93* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05246202
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.05055180
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04690362
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03414080
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03362933
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03094201
99* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03013546
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02668067
101BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99399239
102TFEB_21752829_ChIP-Seq_HELA_Human0.98299040
103RNF2_27304074_Chip-Seq_NSC_Mouse0.96393940
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94882181
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93710849
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93504012
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.93139486
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92855504
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91557368
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90780626
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90724874
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90501120
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.90089168
114ER_23166858_ChIP-Seq_MCF-7_Human0.89175426
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89059529
116PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86207769
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.85570749
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85426681
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85305722
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85119505
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84458394
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84081772
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84004453
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.83330130
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83158869
126KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82875516
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.82692504
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81016842
129SOX2_19829295_ChIP-Seq_ESCs_Human0.80585883
130NANOG_19829295_ChIP-Seq_ESCs_Human0.80585883
131* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79349740
132TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.79214964
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78759963
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78251954
135HTT_18923047_ChIP-ChIP_STHdh_Human0.77895072
136FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76968284
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75738579
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.75426418
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73190920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.55699774
2MP0004957_abnormal_blastocyst_morpholog3.66713705
3MP0001529_abnormal_vocalization3.43285612
4MP0003123_paternal_imprinting3.09803097
5MP0010094_abnormal_chromosome_stability2.94052849
6MP0003077_abnormal_cell_cycle2.89534163
7MP0008932_abnormal_embryonic_tissue2.86251139
8MP0003111_abnormal_nucleus_morphology2.81386568
9MP0008058_abnormal_DNA_repair2.69211690
10MP0008057_abnormal_DNA_replication2.58786400
11MP0003122_maternal_imprinting2.46458216
12MP0008877_abnormal_DNA_methylation2.27520471
13MP0003718_maternal_effect2.14528704
14MP0003121_genomic_imprinting2.07946075
15MP0001905_abnormal_dopamine_level2.01560048
16MP0001730_embryonic_growth_arrest1.98422297
17MP0008007_abnormal_cellular_replicative1.93539827
18MP0002653_abnormal_ependyma_morphology1.88969675
19MP0003787_abnormal_imprinting1.86204070
20MP0003880_abnormal_central_pattern1.85303611
21MP0009379_abnormal_foot_pigmentation1.82385575
22MP0003786_premature_aging1.80264421
23MP0000537_abnormal_urethra_morphology1.75201684
24MP0006072_abnormal_retinal_apoptosis1.72218781
25MP0002837_dystrophic_cardiac_calcinosis1.71302998
26MP0005084_abnormal_gallbladder_morpholo1.70084004
27MP0003890_abnormal_embryonic-extraembry1.63473297
28MP0002102_abnormal_ear_morphology1.63405961
29MP0008995_early_reproductive_senescence1.63379195
30MP0002638_abnormal_pupillary_reflex1.58656807
31MP0003567_abnormal_fetal_cardiomyocyte1.57683659
32MP0000631_abnormal_neuroendocrine_gland1.54942655
33MP0002938_white_spotting1.50599444
34MP0003315_abnormal_perineum_morphology1.49884361
35MP0004147_increased_porphyrin_level1.41705055
36MP0009333_abnormal_splenocyte_physiolog1.40656446
37MP0002210_abnormal_sex_determination1.38479154
38MP0003938_abnormal_ear_development1.38094035
39MP0003186_abnormal_redox_activity1.36255141
40MP0002277_abnormal_respiratory_mucosa1.35692623
41MP0004142_abnormal_muscle_tone1.35139835
42MP0001697_abnormal_embryo_size1.33163476
43MP0006036_abnormal_mitochondrial_physio1.32454542
44MP0005646_abnormal_pituitary_gland1.32428603
45MP0000350_abnormal_cell_proliferation1.30338086
46MP0003806_abnormal_nucleotide_metabolis1.29936467
47MP0004885_abnormal_endolymph1.27881165
48MP0010030_abnormal_orbit_morphology1.27262270
49MP0005551_abnormal_eye_electrophysiolog1.24776390
50MP0001968_abnormal_touch/_nociception1.24373391
51MP0000569_abnormal_digit_pigmentation1.24207263
52MP0001764_abnormal_homeostasis1.23641004
53MP0002396_abnormal_hematopoietic_system1.22038171
54MP0001929_abnormal_gametogenesis1.21771602
55MP0002080_prenatal_lethality1.20218654
56MP0001145_abnormal_male_reproductive1.20186795
57MP0004133_heterotaxia1.19771361
58MP0005499_abnormal_olfactory_system1.18975150
59MP0005394_taste/olfaction_phenotype1.18975150
60MP0001984_abnormal_olfaction1.16303432
61MP0002751_abnormal_autonomic_nervous1.16163248
62MP0002085_abnormal_embryonic_tissue1.15113491
63MP0005645_abnormal_hypothalamus_physiol1.13724361
64MP0002234_abnormal_pharynx_morphology1.12445160
65MP0005379_endocrine/exocrine_gland_phen1.11627881
66MP0002822_catalepsy1.11511905
67MP0005253_abnormal_eye_physiology1.11478036
68MP0001919_abnormal_reproductive_system1.11359103
69MP0006276_abnormal_autonomic_nervous1.11290533
70MP0006292_abnormal_olfactory_placode1.09839462
71MP0003119_abnormal_digestive_system1.09320112
72MP0001485_abnormal_pinna_reflex1.07551861
73MP0005408_hypopigmentation1.07525907
74MP0000653_abnormal_sex_gland1.07234608
75MP0004742_abnormal_vestibular_system1.07221419
76MP0003937_abnormal_limbs/digits/tail_de1.07019106
77MP0001727_abnormal_embryo_implantation1.05856197
78MP0004270_analgesia1.03252704
79MP0001286_abnormal_eye_development1.02517059
80MP0009046_muscle_twitch1.01788552
81MP0002095_abnormal_skin_pigmentation1.01560852
82MP0005075_abnormal_melanosome_morpholog1.01337309
83MP0002132_abnormal_respiratory_system1.01252751
84MP0005380_embryogenesis_phenotype1.00867556
85MP0001672_abnormal_embryogenesis/_devel1.00867556
86MP0002084_abnormal_developmental_patter1.00416697
87MP0000358_abnormal_cell_content/0.98510190
88MP0005174_abnormal_tail_pigmentation0.98351761
89MP0002909_abnormal_adrenal_gland0.98028714
90MP0001324_abnormal_eye_pigmentation0.97653663
91MP0002160_abnormal_reproductive_system0.97595108
92MP0008260_abnormal_autophagy0.97381088
93MP0001293_anophthalmia0.96370421
94MP0002233_abnormal_nose_morphology0.95008945
95MP0002163_abnormal_gland_morphology0.94953081
96MP0000049_abnormal_middle_ear0.93318653
97MP0005451_abnormal_body_composition0.91099548
98MP0000920_abnormal_myelination0.90763000
99MP0008875_abnormal_xenobiotic_pharmacok0.90178787
100MP0001986_abnormal_taste_sensitivity0.89731773
101MP0003861_abnormal_nervous_system0.89349584
102MP0002736_abnormal_nociception_after0.88469842
103MP0003136_yellow_coat_color0.88425872
104MP0000372_irregular_coat_pigmentation0.87911842
105MP0008872_abnormal_physiological_respon0.87417827
106MP0003984_embryonic_growth_retardation0.86860675
107MP0003698_abnormal_male_reproductive0.86567445
108MP0006035_abnormal_mitochondrial_morpho0.86335565
109MP0002557_abnormal_social/conspecific_i0.85771578
110MP0009672_abnormal_birth_weight0.85261174
111MP0000462_abnormal_digestive_system0.84362846
112MP0000313_abnormal_cell_death0.84166613
113MP0003011_delayed_dark_adaptation0.83355170
114MP0001486_abnormal_startle_reflex0.83271331
115MP0002088_abnormal_embryonic_growth/wei0.83042035
116MP0009250_abnormal_appendicular_skeleto0.82891121
117MP0002928_abnormal_bile_duct0.81847832
118MP0005195_abnormal_posterior_eye0.81770184
119MP0002734_abnormal_mechanical_nocicepti0.81496247
120MP0009745_abnormal_behavioral_response0.80570210
121MP0009697_abnormal_copulation0.80199244
122MP0005391_vision/eye_phenotype0.79922893
123MP0005410_abnormal_fertilization0.79205251
124MP0000778_abnormal_nervous_system0.78075555
125MP0000747_muscle_weakness0.76952261
126MP0003221_abnormal_cardiomyocyte_apopto0.75843718
127MP0005389_reproductive_system_phenotype0.75120903
128MP0001188_hyperpigmentation0.74368846
129MP0002184_abnormal_innervation0.74346054
130MP0008789_abnormal_olfactory_epithelium0.74171935
131MP0002114_abnormal_axial_skeleton0.73065280
132MP0003942_abnormal_urinary_system0.71293911
133MP0002161_abnormal_fertility/fecundity0.71062490
134MP0002272_abnormal_nervous_system0.69202386
135MP0002752_abnormal_somatic_nervous0.68800607
136MP0002019_abnormal_tumor_incidence0.65741976
137MP0004145_abnormal_muscle_electrophysio0.65566259
138MP0002735_abnormal_chemical_nociception0.65028018
139MP0002111_abnormal_tail_morphology0.64651727
140MP0004197_abnormal_fetal_growth/weight/0.63767519
141MP0005386_behavior/neurological_phenoty0.62936801
142MP0004924_abnormal_behavior0.62936801
143MP0005384_cellular_phenotype0.62556065

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.91631685
2Breast hypoplasia (HP:0003187)4.26444813
3Abnormality of cells of the erythroid lineage (HP:0012130)4.18352083
4Birth length less than 3rd percentile (HP:0003561)3.97534993
5Abnormal number of erythroid precursors (HP:0012131)3.80876970
6Acute necrotizing encephalopathy (HP:0006965)3.75082521
7Abnormality of glycolysis (HP:0004366)3.50169292
8Increased serum pyruvate (HP:0003542)3.50169292
9Mitochondrial inheritance (HP:0001427)3.48976836
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32404204
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32404204
12Abnormal mitochondria in muscle tissue (HP:0008316)3.24356608
13Increased hepatocellular lipid droplets (HP:0006565)3.23755452
14Hepatocellular necrosis (HP:0001404)3.12285438
15Increased CSF lactate (HP:0002490)3.07008370
16Pancreatic cysts (HP:0001737)3.03351626
17CNS hypomyelination (HP:0003429)3.00514641
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93778918
19Acute encephalopathy (HP:0006846)2.91085087
20Cerebral edema (HP:0002181)2.90554181
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86305686
22Lipid accumulation in hepatocytes (HP:0006561)2.84793831
233-Methylglutaconic aciduria (HP:0003535)2.76902419
24Abnormality of midbrain morphology (HP:0002418)2.74487957
25Molar tooth sign on MRI (HP:0002419)2.74487957
26Progressive macrocephaly (HP:0004481)2.74288660
27Carpal bone hypoplasia (HP:0001498)2.71199070
28Renal Fanconi syndrome (HP:0001994)2.69417218
29Postnatal microcephaly (HP:0005484)2.68626251
30Hypoplastic pelvis (HP:0008839)2.65588325
31True hermaphroditism (HP:0010459)2.64750932
32Supernumerary spleens (HP:0009799)2.61655061
33Increased serum lactate (HP:0002151)2.60425247
34Abnormality of the labia minora (HP:0012880)2.57663116
35Macrocytic anemia (HP:0001972)2.54857502
36Rough bone trabeculation (HP:0100670)2.54821124
37Respiratory difficulties (HP:0002880)2.51364612
38Abnormality of the fetal cardiovascular system (HP:0010948)2.47427706
39Abnormal umbilical cord blood vessels (HP:0011403)2.47427706
40Single umbilical artery (HP:0001195)2.47427706
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46762124
42Abnormality of alanine metabolism (HP:0010916)2.46762124
43Hyperalaninemia (HP:0003348)2.46762124
44Optic disc pallor (HP:0000543)2.45645430
45Hepatic necrosis (HP:0002605)2.45074319
46Nephronophthisis (HP:0000090)2.44760924
47Leukodystrophy (HP:0002415)2.43506768
48Abnormal lung lobation (HP:0002101)2.42609698
49Volvulus (HP:0002580)2.41985325
50Abnormality of the umbilical cord (HP:0010881)2.41845447
51Increased intramyocellular lipid droplets (HP:0012240)2.41451096
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.39053762
53Exertional dyspnea (HP:0002875)2.32399030
54Sclerocornea (HP:0000647)2.30718393
55Meckel diverticulum (HP:0002245)2.28494700
56Exercise intolerance (HP:0003546)2.27171164
57Medial flaring of the eyebrow (HP:0010747)2.24953043
58Type I transferrin isoform profile (HP:0003642)2.24344546
59Asplenia (HP:0001746)2.22766369
60Abnormality of the ileum (HP:0001549)2.20736038
61Patellar aplasia (HP:0006443)2.20658917
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.20556186
63Secondary amenorrhea (HP:0000869)2.20011448
64Spastic paraparesis (HP:0002313)2.17543665
65Lactic acidosis (HP:0003128)2.16451588
66Degeneration of anterior horn cells (HP:0002398)2.16433396
67Abnormality of the anterior horn cell (HP:0006802)2.16433396
68Respiratory failure (HP:0002878)2.15520258
69Type II lissencephaly (HP:0007260)2.14781645
70Irregular epiphyses (HP:0010582)2.14486522
71Microretrognathia (HP:0000308)2.13372942
72Delusions (HP:0000746)2.11606282
73Trismus (HP:0000211)2.11350329
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09956505
75Stenosis of the external auditory canal (HP:0000402)2.09078482
76Aplasia/Hypoplasia of the patella (HP:0006498)2.07487967
77Diastasis recti (HP:0001540)2.07248703
78Congenital stationary night blindness (HP:0007642)2.07016723
79Emotional lability (HP:0000712)2.06805824
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05496696
81Abnormality of the renal medulla (HP:0100957)2.05057772
82Abnormality of renal resorption (HP:0011038)2.04954779
83Abnormality of the pons (HP:0007361)2.03752165
84Hyperglycinemia (HP:0002154)2.03314494
85Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01756164
86Glossoptosis (HP:0000162)2.00898692
87Adrenal hypoplasia (HP:0000835)2.00881530
88Abnormal protein glycosylation (HP:0012346)1.99214447
89Abnormal glycosylation (HP:0012345)1.99214447
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99214447
91Abnormal protein N-linked glycosylation (HP:0012347)1.99214447
92Bile duct proliferation (HP:0001408)1.97837149
93Abnormal biliary tract physiology (HP:0012439)1.97837149
94Absent thumb (HP:0009777)1.97123473
95Microvesicular hepatic steatosis (HP:0001414)1.95980389
96Hypothermia (HP:0002045)1.95350618
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.94539203
98Rib fusion (HP:0000902)1.93996252
99Poor suck (HP:0002033)1.93991021
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.93880593
101Reticulocytopenia (HP:0001896)1.93780056
102Hypoplasia of the pons (HP:0012110)1.93630835
103Muscle fiber atrophy (HP:0100295)1.92682824
104CNS demyelination (HP:0007305)1.91926861
105Hyperglycinuria (HP:0003108)1.91575753
106Increased muscle lipid content (HP:0009058)1.91040552
107Abnormality of the renal cortex (HP:0011035)1.90683183
108Pallor (HP:0000980)1.89904013
109Sensory axonal neuropathy (HP:0003390)1.89752303
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88404253
111Lethargy (HP:0001254)1.87470761
112Aplastic anemia (HP:0001915)1.86338667
113Abnormality of chromosome stability (HP:0003220)1.84965747
114Retinal dysplasia (HP:0007973)1.84607968
115Type 2 muscle fiber atrophy (HP:0003554)1.83217469
116Anencephaly (HP:0002323)1.82630271
117Septo-optic dysplasia (HP:0100842)1.82206950
118Oral leukoplakia (HP:0002745)1.81923952
119Abnormality of the preputium (HP:0100587)1.81140451
120Abnormality of urine glucose concentration (HP:0011016)1.80739652
121Glycosuria (HP:0003076)1.80739652
122Male pseudohermaphroditism (HP:0000037)1.80503661
123Oligodactyly (hands) (HP:0001180)1.80341200
124Unsteady gait (HP:0002317)1.80053007
125Nephrogenic diabetes insipidus (HP:0009806)1.79963865
126Triphalangeal thumb (HP:0001199)1.79676390
127Broad distal phalanx of finger (HP:0009836)1.79137502
128Congenital, generalized hypertrichosis (HP:0004540)1.78480319
129Premature ovarian failure (HP:0008209)1.78299126
130Pancreatic fibrosis (HP:0100732)1.77918987
131Methylmalonic acidemia (HP:0002912)1.77707279
132Abnormality of serum amino acid levels (HP:0003112)1.77020761
133Absent epiphyses (HP:0010577)1.76478985
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76478985
135Congenital primary aphakia (HP:0007707)1.76191617
136Gait imbalance (HP:0002141)1.75115002
137Poor head control (HP:0002421)1.74775871
138Abnormal hair whorl (HP:0010721)1.74645217
139Split foot (HP:0001839)1.74227584
140Rimmed vacuoles (HP:0003805)1.73252418
141Female pseudohermaphroditism (HP:0010458)1.72157474
142Methylmalonic aciduria (HP:0012120)1.70840818
143Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69480055
144Renal cortical cysts (HP:0000803)1.68638379
145Pendular nystagmus (HP:0012043)1.68548051
146Atresia of the external auditory canal (HP:0000413)1.68271800
147Poor speech (HP:0002465)1.66251240
148Overlapping toe (HP:0001845)1.66033811
149Colon cancer (HP:0003003)1.65421069
150Lissencephaly (HP:0001339)1.64855125
151X-linked dominant inheritance (HP:0001423)1.64369954
152Bilateral microphthalmos (HP:0007633)1.64035898
153Chronic hepatic failure (HP:0100626)1.62810888
154Pancytopenia (HP:0001876)1.62294573
155Anophthalmia (HP:0000528)1.61535855
156Limb dystonia (HP:0002451)1.60610057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.60844755
2WEE13.83737512
3STK163.33358427
4NME23.12256726
5VRK23.11534525
6EIF2AK12.94690787
7ARAF2.85673384
8TRIM282.41553722
9SRPK12.40023023
10ZAK2.31991819
11TSSK62.27782601
12ADRBK22.22466064
13BRAF2.20916133
14MAP4K22.15648252
15CDC72.08754355
16NUAK12.00540846
17BRSK21.99180467
18CCNB11.98321285
19ACVR1B1.96521460
20PNCK1.93749792
21VRK11.82705479
22LIMK11.79753587
23DYRK31.73517788
24EIF2AK31.70213638
25FRK1.68253963
26TAF11.62199508
27PLK41.53759601
28TESK21.53103485
29CDK191.52724215
30STK391.51833194
31MAP3K41.51449149
32MAP2K71.49856863
33TIE11.46940959
34MAP3K91.46839033
35DYRK21.41096515
36NME11.36896426
37PASK1.36628689
38PLK31.33546644
39AURKA1.33184973
40MKNK11.33098995
41CSNK1G31.32791329
42PLK11.29992102
43TTK1.29705203
44GRK11.26628026
45ERBB31.23753348
46BCR1.23265705
47BCKDK1.19755387
48MARK11.18532110
49BRSK11.17723662
50RAF11.12157704
51INSRR1.11875926
52PDK21.11075094
53CDK81.09784578
54PIM21.09015463
55CASK1.08979725
56OXSR11.07703362
57MST41.06615704
58PRKCG1.01926587
59CSNK1G11.01553752
60NEK21.00039554
61PAK10.99775975
62CHEK20.97616184
63WNK40.95957601
64CDK70.94210796
65MUSK0.93935617
66MKNK20.90486219
67PINK10.87405694
68MINK10.86756554
69MAP3K120.85671190
70KSR20.84673873
71AURKB0.84399299
72UHMK10.82943528
73AKT30.79627469
74CDK140.79584141
75CSNK1G20.78985323
76LATS20.77019327
77TGFBR10.74443400
78CSNK1A1L0.72099970
79MAP3K110.72089587
80TESK10.71686617
81TNIK0.70454371
82MAP3K80.69311408
83CLK10.67857159
84FGFR20.66646345
85ATM0.66475215
86CSNK2A20.65815171
87RPS6KB20.64384894
88CDK180.62464504
89KDR0.62154585
90CDK11A0.61885881
91ILK0.60410926
92PRKCI0.60235076
93WNK30.60159083
94CDK150.60153104
95PAK30.60013169
96GRK50.59514358
97CHEK10.58081538
98CDK30.56104785
99NEK10.56024162
100MAPKAPK50.55847677
101TYRO30.55824538
102MOS0.55563659
103CSNK2A10.55341834
104PRKCE0.55122088
105CSNK1A10.54401889
106ATR0.53582576
107TEC0.51922844
108TLK10.50764510
109ZAP700.49825420
110KSR10.49756120
111PIK3CA0.48776238
112MAPK150.47099566
113STK40.46832229
114MAPK130.45777775
115PDK40.44159745
116PDK30.44159745
117IRAK20.44029042
118ABL20.43553020
119EIF2AK20.43309491
120DYRK1A0.41869713
121PBK0.41578241
122IRAK10.39218778
123RPS6KA40.39130148
124CDK20.38262306
125MELK0.38132981
126TAOK30.38064574
127NTRK20.37412133
128MET0.37300546
129BMPR1B0.36290778
130ROCK20.35314794
131CAMK2B0.35298856
132CSNK1E0.35247667
133CDK10.35115351
134ADRBK10.34725262
135PLK20.34589216
136STK30.34359182
137MYLK0.34331428
138SCYL20.33183571
139RPS6KA50.32832580
140CAMK2G0.31617245
141MAP2K20.28159023

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.56515467
2Ribosome_Homo sapiens_hsa030104.25310385
3RNA polymerase_Homo sapiens_hsa030204.10040207
4DNA replication_Homo sapiens_hsa030303.42249862
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14652802
6Spliceosome_Homo sapiens_hsa030403.05825525
7Protein export_Homo sapiens_hsa030603.04672695
8Mismatch repair_Homo sapiens_hsa034302.83063281
9Oxidative phosphorylation_Homo sapiens_hsa001902.82289346
10RNA transport_Homo sapiens_hsa030132.59261848
11Parkinsons disease_Homo sapiens_hsa050122.53300153
12Pyrimidine metabolism_Homo sapiens_hsa002402.51063700
13Base excision repair_Homo sapiens_hsa034102.48549768
14Nucleotide excision repair_Homo sapiens_hsa034202.48487330
15Cell cycle_Homo sapiens_hsa041102.20309756
16* Basal transcription factors_Homo sapiens_hsa030222.20274434
17Homologous recombination_Homo sapiens_hsa034402.13974896
18Huntingtons disease_Homo sapiens_hsa050162.13073795
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01252111
20Non-homologous end-joining_Homo sapiens_hsa034501.98911745
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91760166
22RNA degradation_Homo sapiens_hsa030181.66594531
23Alzheimers disease_Homo sapiens_hsa050101.61995539
24Vitamin B6 metabolism_Homo sapiens_hsa007501.58526548
25Purine metabolism_Homo sapiens_hsa002301.50647801
26Folate biosynthesis_Homo sapiens_hsa007901.49312095
27mRNA surveillance pathway_Homo sapiens_hsa030151.42762168
28Oocyte meiosis_Homo sapiens_hsa041141.27808032
29Propanoate metabolism_Homo sapiens_hsa006401.26895891
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23074444
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21963763
32Fanconi anemia pathway_Homo sapiens_hsa034601.20614658
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14224434
34Phototransduction_Homo sapiens_hsa047441.13149707
35Butanoate metabolism_Homo sapiens_hsa006501.05825702
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03984394
37Epstein-Barr virus infection_Homo sapiens_hsa051691.03317593
38Regulation of autophagy_Homo sapiens_hsa041401.03087954
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.98812848
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93254554
41Nicotine addiction_Homo sapiens_hsa050330.91916555
42Sulfur relay system_Homo sapiens_hsa041220.89097420
43Cardiac muscle contraction_Homo sapiens_hsa042600.81017713
44p53 signaling pathway_Homo sapiens_hsa041150.79862068
45Ether lipid metabolism_Homo sapiens_hsa005650.77766633
46Steroid biosynthesis_Homo sapiens_hsa001000.76019329
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75214876
48Peroxisome_Homo sapiens_hsa041460.73519062
49Vibrio cholerae infection_Homo sapiens_hsa051100.73199853
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72659449
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.71357744
52Tryptophan metabolism_Homo sapiens_hsa003800.70510212
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70309531
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69562953
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69368823
56Nitrogen metabolism_Homo sapiens_hsa009100.68813811
57Glutathione metabolism_Homo sapiens_hsa004800.68651392
58Fatty acid elongation_Homo sapiens_hsa000620.68411911
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68370648
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67513395
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66530831
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65762255
63Caffeine metabolism_Homo sapiens_hsa002320.65488469
64Collecting duct acid secretion_Homo sapiens_hsa049660.63906325
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.63340376
66Thyroid cancer_Homo sapiens_hsa052160.62842668
67Sulfur metabolism_Homo sapiens_hsa009200.59385562
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58938555
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56261700
70Pentose phosphate pathway_Homo sapiens_hsa000300.55208754
71Metabolic pathways_Homo sapiens_hsa011000.54897610
72Olfactory transduction_Homo sapiens_hsa047400.53313497
73N-Glycan biosynthesis_Homo sapiens_hsa005100.51159617
74Chemical carcinogenesis_Homo sapiens_hsa052040.50754050
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44290380
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44211837
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43690757
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43464701
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43334173
80One carbon pool by folate_Homo sapiens_hsa006700.42375850
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41868372
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41868207
83Taste transduction_Homo sapiens_hsa047420.40464058
84Hedgehog signaling pathway_Homo sapiens_hsa043400.40318015
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37965078
86Arachidonic acid metabolism_Homo sapiens_hsa005900.35764684
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35191404
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33271632
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.32191774
90Retinol metabolism_Homo sapiens_hsa008300.32036279
91Hippo signaling pathway_Homo sapiens_hsa043900.31618434
92Alcoholism_Homo sapiens_hsa050340.31086262
93TGF-beta signaling pathway_Homo sapiens_hsa043500.30966999
94Linoleic acid metabolism_Homo sapiens_hsa005910.30123613
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29280107
96beta-Alanine metabolism_Homo sapiens_hsa004100.28815850
97Tyrosine metabolism_Homo sapiens_hsa003500.28752870
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28224420
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.28166388
100Fat digestion and absorption_Homo sapiens_hsa049750.27322364
101Pyruvate metabolism_Homo sapiens_hsa006200.27267130
102Arginine and proline metabolism_Homo sapiens_hsa003300.26538398
103Wnt signaling pathway_Homo sapiens_hsa043100.25545348
104Biosynthesis of amino acids_Homo sapiens_hsa012300.24575266
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.24418275
106Sphingolipid metabolism_Homo sapiens_hsa006000.23090125
107Viral carcinogenesis_Homo sapiens_hsa052030.21925998
108Shigellosis_Homo sapiens_hsa051310.21543697
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19292096
110Morphine addiction_Homo sapiens_hsa050320.19281039
111Synaptic vesicle cycle_Homo sapiens_hsa047210.19216724
112Carbon metabolism_Homo sapiens_hsa012000.18787935
113Fatty acid metabolism_Homo sapiens_hsa012120.18757465
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17403490
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17284602
116Serotonergic synapse_Homo sapiens_hsa047260.17276015
117Fatty acid degradation_Homo sapiens_hsa000710.16967339
118GABAergic synapse_Homo sapiens_hsa047270.16408751
119HTLV-I infection_Homo sapiens_hsa051660.16008337
120Systemic lupus erythematosus_Homo sapiens_hsa053220.15215634
121Basal cell carcinoma_Homo sapiens_hsa052170.14488119
122Tight junction_Homo sapiens_hsa045300.13948875
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13709252
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.13658036
125Renal cell carcinoma_Homo sapiens_hsa052110.12414388
126Antigen processing and presentation_Homo sapiens_hsa046120.12172528
127Fructose and mannose metabolism_Homo sapiens_hsa000510.11287592
128Amphetamine addiction_Homo sapiens_hsa050310.10671551
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10499702
130Dopaminergic synapse_Homo sapiens_hsa047280.10421284
131Prostate cancer_Homo sapiens_hsa052150.09884530
132Axon guidance_Homo sapiens_hsa043600.09511476
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09508064
134Endocytosis_Homo sapiens_hsa041440.08234491
135Melanoma_Homo sapiens_hsa052180.05392824
136Long-term potentiation_Homo sapiens_hsa047200.05193346
137Long-term depression_Homo sapiens_hsa047300.05187674
138Colorectal cancer_Homo sapiens_hsa052100.05044113
139Herpes simplex infection_Homo sapiens_hsa051680.04402318
140Selenocompound metabolism_Homo sapiens_hsa004500.03995018

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