TAF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.63470807
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.54684613
3replication fork processing (GO:0031297)5.51550364
4maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.02672821
5telomere maintenance via semi-conservative replication (GO:0032201)4.87639131
6proline biosynthetic process (GO:0006561)4.77115448
7ATP synthesis coupled proton transport (GO:0015986)4.69621272
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.69621272
9viral mRNA export from host cell nucleus (GO:0046784)4.59585359
10transcription from mitochondrial promoter (GO:0006390)4.58704746
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39698491
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31031480
13telomere maintenance via recombination (GO:0000722)4.29335050
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.19020298
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.15871159
16chaperone-mediated protein transport (GO:0072321)4.14421511
17nucleotide-excision repair, DNA gap filling (GO:0006297)4.12243988
18kinetochore assembly (GO:0051382)4.11250187
19somatic diversification of immune receptors via somatic mutation (GO:0002566)4.07117949
20somatic hypermutation of immunoglobulin genes (GO:0016446)4.07117949
21DNA strand elongation involved in DNA replication (GO:0006271)4.05326082
22respiratory electron transport chain (GO:0022904)4.04128984
23regulation of cellular amino acid metabolic process (GO:0006521)4.03357479
24negative regulation of ligase activity (GO:0051352)3.99559884
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.99559884
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.98610081
27electron transport chain (GO:0022900)3.97673756
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95594350
29DNA integration (GO:0015074)3.92414653
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.90557378
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.90557378
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.90557378
33DNA strand elongation (GO:0022616)3.89725335
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.87982836
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.87982836
36regulation of double-strand break repair via homologous recombination (GO:0010569)3.86405822
37maturation of 5.8S rRNA (GO:0000460)3.82392094
38poly(A)+ mRNA export from nucleus (GO:0016973)3.74733212
39meiotic chromosome segregation (GO:0045132)3.73232284
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.72943782
41mitotic recombination (GO:0006312)3.72762653
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.72610269
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.72610269
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.70202663
45kinetochore organization (GO:0051383)3.69350612
46telomere maintenance via telomere lengthening (GO:0010833)3.68462258
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.61437054
48positive regulation of ligase activity (GO:0051351)3.58651597
49proline metabolic process (GO:0006560)3.56320219
50formation of translation preinitiation complex (GO:0001731)3.55225055
51positive regulation of protein homooligomerization (GO:0032464)3.54043235
52protein complex biogenesis (GO:0070271)3.48260237
53proteasome assembly (GO:0043248)3.44112389
54DNA strand renaturation (GO:0000733)3.43724182
55synapsis (GO:0007129)3.43259704
56DNA replication checkpoint (GO:0000076)3.42912839
57pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.36801032
58DNA ligation (GO:0006266)3.35352540
59mitochondrial respiratory chain complex assembly (GO:0033108)3.33911181
60base-excision repair, AP site formation (GO:0006285)3.33699174
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30761948
62regulation of ubiquitin-protein transferase activity (GO:0051438)3.30199709
63histone exchange (GO:0043486)3.30189561
64embryonic process involved in female pregnancy (GO:0060136)3.29781702
65pseudouridine synthesis (GO:0001522)3.29759851
66oxidative demethylation (GO:0070989)3.29103743
67maturation of SSU-rRNA (GO:0030490)3.27685973
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27419032
69cotranslational protein targeting to membrane (GO:0006613)3.25831883
70DNA double-strand break processing (GO:0000729)3.25515232
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24752825
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24752825
73rRNA methylation (GO:0031167)3.24463187
74centriole replication (GO:0007099)3.23973112
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23963402
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.23963402
77NADH dehydrogenase complex assembly (GO:0010257)3.23963402
78protein targeting to ER (GO:0045047)3.22459031
79base-excision repair (GO:0006284)3.21172079
80regulation of ligase activity (GO:0051340)3.20042059
81DNA replication initiation (GO:0006270)3.19057605
82viral transcription (GO:0019083)3.18141896
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17088929
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17007766
85transcription-coupled nucleotide-excision repair (GO:0006283)3.16834186
86protein targeting to mitochondrion (GO:0006626)3.16638436
87translation (GO:0006412)3.16363370
88translational termination (GO:0006415)3.16139277
89ribosome biogenesis (GO:0042254)3.15990993
90rRNA processing (GO:0006364)3.12781068
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.11890705
92protein localization to endoplasmic reticulum (GO:0070972)3.10900317
93establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08340402
94DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.08033361
95spliceosomal snRNP assembly (GO:0000387)3.04104542
96protein deneddylation (GO:0000338)3.03373505
97mitochondrial RNA metabolic process (GO:0000959)3.03370658
98cytochrome complex assembly (GO:0017004)3.02841701
99respiratory chain complex IV assembly (GO:0008535)3.02509939
100rRNA metabolic process (GO:0016072)3.02034942
101termination of RNA polymerase II transcription (GO:0006369)3.01798193
102regulation of spindle checkpoint (GO:0090231)2.97460814
103positive regulation of cell cycle arrest (GO:0071158)2.97093740
104ribosomal small subunit assembly (GO:0000028)2.96911338
105regulation of mitochondrial translation (GO:0070129)2.96864098
106translational initiation (GO:0006413)2.95842074
107rRNA modification (GO:0000154)2.94356862
108somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94073769
109isotype switching (GO:0045190)2.94073769
110somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94073769
111mitochondrial DNA metabolic process (GO:0032042)2.93898992
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93645002
113protein localization to mitochondrion (GO:0070585)2.92374833
114water-soluble vitamin biosynthetic process (GO:0042364)2.90940682
115non-recombinational repair (GO:0000726)2.90256926
116double-strand break repair via nonhomologous end joining (GO:0006303)2.90256926
117protein K6-linked ubiquitination (GO:0085020)2.89866769
118mismatch repair (GO:0006298)2.89699386
119mitotic metaphase plate congression (GO:0007080)2.89417186
120CENP-A containing nucleosome assembly (GO:0034080)2.89055565
121protein-cofactor linkage (GO:0018065)2.89055267
122ribosomal small subunit biogenesis (GO:0042274)2.88431149
123termination of RNA polymerase III transcription (GO:0006386)2.88143822
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.88143822
125establishment of protein localization to mitochondrion (GO:0072655)2.87812409
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.86075784
127translational elongation (GO:0006414)2.85939840
128DNA replication-independent nucleosome assembly (GO:0006336)2.85926491
129DNA replication-independent nucleosome organization (GO:0034724)2.85926491
130peptidyl-histidine modification (GO:0018202)2.85634166
131pyrimidine nucleotide catabolic process (GO:0006244)2.85499374
132ribosome assembly (GO:0042255)2.85426143
133DNA catabolic process, exonucleolytic (GO:0000738)2.85179657
134negative regulation of protein ubiquitination (GO:0031397)2.85174236
1357-methylguanosine mRNA capping (GO:0006370)2.84585467
136cullin deneddylation (GO:0010388)2.84025069
137positive regulation of DNA repair (GO:0045739)2.83927657
138regulation of cellular amine metabolic process (GO:0033238)2.83563632
139male meiosis I (GO:0007141)2.81178271
140ribonucleoprotein complex biogenesis (GO:0022613)2.81001587
141protein neddylation (GO:0045116)2.80851284
142chromatin remodeling at centromere (GO:0031055)2.80814411
143DNA demethylation (GO:0080111)2.79706846
144regulation of double-strand break repair (GO:2000779)2.74108974
145mitochondrial DNA replication (GO:0006264)2.71013876
146DNA-dependent DNA replication (GO:0006261)2.70265368
147GDP-mannose metabolic process (GO:0019673)2.68738785
148DNA-templated transcription, termination (GO:0006353)2.68304520
149DNA topological change (GO:0006265)2.67061442
150regulation of integrin activation (GO:0033623)2.67050331
151mitotic sister chromatid segregation (GO:0000070)2.64416200
152cellular response to zinc ion (GO:0071294)2.63733640
153resolution of meiotic recombination intermediates (GO:0000712)2.63460473
154ribosomal large subunit biogenesis (GO:0042273)2.62029578
155tRNA methylation (GO:0030488)2.61357931
156telomere maintenance (GO:0000723)2.61219669
157telomere organization (GO:0032200)2.60356728
158tRNA modification (GO:0006400)2.57148976
159positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55410492
160positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55410492
161positive regulation of mitotic sister chromatid separation (GO:1901970)2.55410492
162mRNA cleavage (GO:0006379)2.54693164
163single strand break repair (GO:0000012)2.53883821
164G1/S transition of mitotic cell cycle (GO:0000082)2.53586643
165cell cycle G1/S phase transition (GO:0044843)2.53586643
166deoxyribonucleotide catabolic process (GO:0009264)2.51269293
167histone mRNA metabolic process (GO:0008334)2.50723488
168regulation of nuclear cell cycle DNA replication (GO:0033262)2.50398020
169deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50240185
170dosage compensation (GO:0007549)2.49219737
171ncRNA processing (GO:0034470)2.47183569
172somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.46956394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.22955018
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.99007503
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39137448
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24869803
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.17745799
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02615287
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.00263291
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97425252
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88927288
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72397084
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58455984
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56985029
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.56443912
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37612839
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30969563
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.26706124
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.25261188
18VDR_23849224_ChIP-Seq_CD4+_Human2.24990627
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24331875
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14538205
21DCP1A_22483619_ChIP-Seq_HELA_Human2.11468208
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07718249
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06095292
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04826458
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03651589
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.00843543
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97297703
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96479028
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.94293778
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92137683
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90598488
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90371182
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86319232
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84598930
35* GABP_19822575_ChIP-Seq_HepG2_Human1.83734125
36FOXP3_21729870_ChIP-Seq_TREG_Human1.83536859
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82815388
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82385135
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82385135
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82385135
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78432697
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75041069
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74468442
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72306091
45TTF2_22483619_ChIP-Seq_HELA_Human1.70489139
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69403067
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69068550
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.68324728
49XRN2_22483619_ChIP-Seq_HELA_Human1.65172500
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.64360700
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62672204
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60841684
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56854445
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52936568
55ZNF274_21170338_ChIP-Seq_K562_Hela1.52901822
56* ELK1_19687146_ChIP-ChIP_HELA_Human1.52348688
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52216341
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51393195
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.49798191
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46087951
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.42785076
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.41519576
63* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41332227
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.41118513
65VDR_22108803_ChIP-Seq_LS180_Human1.40261257
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37669653
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.37589191
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.36881079
69EWS_26573619_Chip-Seq_HEK293_Human1.35844206
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31572943
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.30992015
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29029407
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26893991
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26798236
75IRF1_19129219_ChIP-ChIP_H3396_Human1.24583222
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21618921
77SPI1_23547873_ChIP-Seq_NB4_Human1.21418721
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17856340
79VDR_21846776_ChIP-Seq_THP-1_Human1.16382081
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14972238
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13955613
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12197747
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11040388
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08386573
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08051898
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07127702
87KDM5A_27292631_Chip-Seq_BREAST_Human1.05838033
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05635641
89TP53_22573176_ChIP-Seq_HFKS_Human1.04601283
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03681977
91MYC_18940864_ChIP-ChIP_HL60_Human1.01303600
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00106633
93* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99781386
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99736777
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99367003
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97058469
97* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96831361
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96555239
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95905988
100IGF1R_20145208_ChIP-Seq_DFB_Human0.94818588
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94404090
102AR_21909140_ChIP-Seq_LNCAP_Human0.93435418
103* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93178623
104STAT1_20625510_ChIP-Seq_HELA_Human0.91962845
105SALL4_22934838_ChIP-ChIP_CD34+_Human0.91610491
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90644509
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90012144
108KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89678218
109AR_20517297_ChIP-Seq_VCAP_Human0.89261900
110FUS_26573619_Chip-Seq_HEK293_Human0.87691725
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87405680
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86957304
113* NANOG_16153702_ChIP-ChIP_HESCs_Human0.86206172
114* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85554368
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85125517
116NANOG_19829295_ChIP-Seq_ESCs_Human0.84558118
117SOX2_19829295_ChIP-Seq_ESCs_Human0.84558118
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84431516
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84241513
120EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84074867
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83121874
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81127888
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80987575
124ELF5_23300383_ChIP-Seq_T47D_Human0.80908162
125TFEB_21752829_ChIP-Seq_HELA_Human0.80896488
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80864968
127* RBPJ_21746931_ChIP-Seq_IB4_Human0.80862117
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80738140
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80558068
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77898785
131FOXA1_25329375_ChIP-Seq_VCAP_Human0.77898785
132* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77549410
133* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76905018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.50666478
2MP0003806_abnormal_nucleotide_metabolis4.00125478
3MP0010094_abnormal_chromosome_stability3.54522116
4MP0008058_abnormal_DNA_repair3.28247177
5MP0003693_abnormal_embryo_hatching3.17161726
6MP0005171_absent_coat_pigmentation2.81438943
7MP0003111_abnormal_nucleus_morphology2.71288007
8MP0004957_abnormal_blastocyst_morpholog2.62297446
9MP0000372_irregular_coat_pigmentation2.53086339
10MP0003786_premature_aging2.49916059
11MP0002132_abnormal_respiratory_system2.47622062
12MP0003077_abnormal_cell_cycle2.47562138
13MP0006036_abnormal_mitochondrial_physio2.38379993
14MP0002396_abnormal_hematopoietic_system2.26988630
15MP0008007_abnormal_cellular_replicative2.16361388
16MP0005397_hematopoietic_system_phenotyp2.07563909
17MP0001545_abnormal_hematopoietic_system2.07563909
18MP0008877_abnormal_DNA_methylation2.05408195
19MP0009333_abnormal_splenocyte_physiolog1.92435346
20MP0000490_abnormal_crypts_of1.92350182
21MP0003718_maternal_effect1.89675624
22MP0006035_abnormal_mitochondrial_morpho1.88220107
23MP0008932_abnormal_embryonic_tissue1.85816223
24MP0008995_early_reproductive_senescence1.80178493
25MP0000566_synostosis1.78467545
26MP0003195_calcinosis1.77629571
27MP0005174_abnormal_tail_pigmentation1.76582894
28MP0001835_abnormal_antigen_presentation1.75181631
29MP0009278_abnormal_bone_marrow1.72297396
30MP0002163_abnormal_gland_morphology1.72120439
31MP0005075_abnormal_melanosome_morpholog1.71842149
32MP0006292_abnormal_olfactory_placode1.70177014
33MP0003763_abnormal_thymus_physiology1.67295682
34MP0003011_delayed_dark_adaptation1.58986962
35MP0005084_abnormal_gallbladder_morpholo1.58103198
36MP0000015_abnormal_ear_pigmentation1.54058362
37MP0000685_abnormal_immune_system1.47119297
38MP0002160_abnormal_reproductive_system1.44697348
39MP0002009_preneoplasia1.40788990
40MP0001529_abnormal_vocalization1.39628474
41MP0005671_abnormal_response_to1.38663443
42MP0010030_abnormal_orbit_morphology1.34730026
43MP0003136_yellow_coat_color1.33583300
44MP0005389_reproductive_system_phenotype1.32977873
45MP0002277_abnormal_respiratory_mucosa1.27567788
46MP0004147_increased_porphyrin_level1.26384970
47MP0003941_abnormal_skin_development1.26338934
48MP0005379_endocrine/exocrine_gland_phen1.26282520
49MP0002398_abnormal_bone_marrow1.25676178
50MP0002102_abnormal_ear_morphology1.23431088
51MP0003656_abnormal_erythrocyte_physiolo1.22973753
52MP0003724_increased_susceptibility_to1.22876443
53MP0002019_abnormal_tumor_incidence1.22687462
54MP0005408_hypopigmentation1.22192443
55MP0000689_abnormal_spleen_morphology1.20970386
56MP0002405_respiratory_system_inflammati1.19985588
57MP0001986_abnormal_taste_sensitivity1.17007351
58MP0009697_abnormal_copulation1.16692208
59MP0001764_abnormal_homeostasis1.15935228
60MP0001293_anophthalmia1.15382474
61MP0005367_renal/urinary_system_phenotyp1.15047657
62MP0000516_abnormal_urinary_system1.15047657
63MP0003252_abnormal_bile_duct1.15028582
64MP0002736_abnormal_nociception_after1.14063265
65MP0001919_abnormal_reproductive_system1.14057444
66MP0000313_abnormal_cell_death1.13322027
67MP0001119_abnormal_female_reproductive1.13307917
68MP0005083_abnormal_biliary_tract1.13216640
69MP0002148_abnormal_hypersensitivity_rea1.12352547
70MP0010307_abnormal_tumor_latency1.12295081
71MP0009785_altered_susceptibility_to1.12189482
72MP0002210_abnormal_sex_determination1.11018626
73MP0003186_abnormal_redox_activity1.10685905
74MP0000569_abnormal_digit_pigmentation1.10484022
75MP0000358_abnormal_cell_content/1.10057000
76MP0001800_abnormal_humoral_immune1.09382064
77MP0005253_abnormal_eye_physiology1.05784971
78MP0002837_dystrophic_cardiac_calcinosis1.04824306
79MP0002722_abnormal_immune_system1.04271177
80MP0000350_abnormal_cell_proliferation1.03980955
81MP0005395_other_phenotype1.03676838
82MP0005410_abnormal_fertilization1.01767418
83MP0002249_abnormal_larynx_morphology1.01377761
84MP0000716_abnormal_immune_system1.00734205
85MP0002429_abnormal_blood_cell1.00504573
86MP0002452_abnormal_antigen_presenting0.99695689
87MP0001145_abnormal_male_reproductive0.98121796
88MP0000703_abnormal_thymus_morphology0.96787678
89MP0001819_abnormal_immune_cell0.96072924
90MP0002420_abnormal_adaptive_immunity0.96055152
91MP0003646_muscle_fatigue0.95242362
92MP0001929_abnormal_gametogenesis0.94976708
93MP0008875_abnormal_xenobiotic_pharmacok0.94830467
94MP0000470_abnormal_stomach_morphology0.94111533
95MP0008789_abnormal_olfactory_epithelium0.93915743
96MP0009764_decreased_sensitivity_to0.93437063
97MP0000681_abnormal_thyroid_gland0.92693597
98MP0002723_abnormal_immune_serum0.92091865
99MP0005645_abnormal_hypothalamus_physiol0.91005333
100MP0002095_abnormal_skin_pigmentation0.90987729
101MP0003698_abnormal_male_reproductive0.90683546
102MP0001346_abnormal_lacrimal_gland0.90586319
103MP0008873_increased_physiological_sensi0.89751206
104MP0005025_abnormal_response_to0.89447945
105MP0004142_abnormal_muscle_tone0.89249088
106MP0000647_abnormal_sebaceous_gland0.88813535
107MP0010386_abnormal_urinary_bladder0.88188529
108MP0000653_abnormal_sex_gland0.87117586
109MP0008872_abnormal_physiological_respon0.87116024
110MP0002006_tumorigenesis0.86622752
111MP0001873_stomach_inflammation0.86055395
112MP0001697_abnormal_embryo_size0.85251268
113MP0002086_abnormal_extraembryonic_tissu0.84181432
114MP0005000_abnormal_immune_tolerance0.83050500
115MP0003828_pulmonary_edema0.82355665
116MP0001790_abnormal_immune_system0.80601169
117MP0005387_immune_system_phenotype0.80601169
118MP0003567_abnormal_fetal_cardiomyocyte0.80505537
119MP0001853_heart_inflammation0.79941450
120MP0005085_abnormal_gallbladder_physiolo0.78876066
121MP0001324_abnormal_eye_pigmentation0.78678515
122MP0004782_abnormal_surfactant_physiolog0.78328535
123MP0002419_abnormal_innate_immunity0.77826997
124MP0005551_abnormal_eye_electrophysiolog0.77329393
125MP0002085_abnormal_embryonic_tissue0.77125672
126MP0005670_abnormal_white_adipose0.77063371
127MP0001186_pigmentation_phenotype0.76873017
128MP0002075_abnormal_coat/hair_pigmentati0.75841038
129MP0003890_abnormal_embryonic-extraembry0.74092383
130MP0003453_abnormal_keratinocyte_physiol0.74087891
131MP0002938_white_spotting0.73688036
132MP0006082_CNS_inflammation0.73677069
133MP0002282_abnormal_trachea_morphology0.73614986
134MP0005332_abnormal_amino_acid0.72906938
135MP0004133_heterotaxia0.72601940
136MP0005380_embryogenesis_phenotype0.72355049
137MP0001672_abnormal_embryogenesis/_devel0.72355049
138MP0003943_abnormal_hepatobiliary_system0.71717380
139MP0003787_abnormal_imprinting0.71426070
140MP0001881_abnormal_mammary_gland0.71406421
141MP0006054_spinal_hemorrhage0.70948136
142MP0006072_abnormal_retinal_apoptosis0.70175709
143MP0000858_altered_metastatic_potential0.70049947
144MP0001727_abnormal_embryo_implantation0.69523775
145MP0010155_abnormal_intestine_physiology0.69498014
146MP0001905_abnormal_dopamine_level0.66598029

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.95204531
2Abnormal mitochondria in muscle tissue (HP:0008316)4.45670599
3Mitochondrial inheritance (HP:0001427)4.45529623
4Acute encephalopathy (HP:0006846)4.40810318
5Increased CSF lactate (HP:0002490)4.34649481
6Progressive macrocephaly (HP:0004481)4.19769206
7Hepatocellular necrosis (HP:0001404)4.07411382
8Birth length less than 3rd percentile (HP:0003561)4.06618496
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04431370
10Chromsome breakage (HP:0040012)3.95716809
11Hepatic necrosis (HP:0002605)3.72276544
12Increased IgM level (HP:0003496)3.64901682
13Lipid accumulation in hepatocytes (HP:0006561)3.51701865
14Patellar aplasia (HP:0006443)3.43363041
15Type 2 muscle fiber atrophy (HP:0003554)3.39140415
16Renal Fanconi syndrome (HP:0001994)3.35045332
17Cerebral edema (HP:0002181)3.27277088
18Pustule (HP:0200039)3.21602698
19Aplasia/Hypoplasia of the patella (HP:0006498)3.15556269
20Rib fusion (HP:0000902)3.15106493
21Muscle fiber atrophy (HP:0100295)3.09787718
22Abnormality of the ileum (HP:0001549)3.09111895
23Exertional dyspnea (HP:0002875)3.07911316
24Breast hypoplasia (HP:0003187)3.06255898
25Reticulocytopenia (HP:0001896)3.02692675
26Absent radius (HP:0003974)3.00929930
27Increased serum lactate (HP:0002151)3.00216427
28Concave nail (HP:0001598)2.95657579
29Absent thumb (HP:0009777)2.93589967
30Lactic acidosis (HP:0003128)2.93507418
31Premature graying of hair (HP:0002216)2.91921556
32Increased intramyocellular lipid droplets (HP:0012240)2.85381801
33Abnormality of the preputium (HP:0100587)2.84589765
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.84256781
35Methylmalonic acidemia (HP:0002912)2.81826732
36Duplicated collecting system (HP:0000081)2.80850212
37Rectal fistula (HP:0100590)2.78031742
38Rectovaginal fistula (HP:0000143)2.78031742
39Aplasia involving forearm bones (HP:0009822)2.77272734
40Absent forearm bone (HP:0003953)2.77272734
41Tongue fasciculations (HP:0001308)2.77095857
42Reduced antithrombin III activity (HP:0001976)2.70050243
43Abnormality of male internal genitalia (HP:0000022)2.69787086
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66046234
45Abnormal protein N-linked glycosylation (HP:0012347)2.66046234
46Abnormal protein glycosylation (HP:0012346)2.66046234
47Abnormal glycosylation (HP:0012345)2.66046234
48Poikiloderma (HP:0001029)2.65910930
49Meckel diverticulum (HP:0002245)2.65338473
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.55504979
51Respiratory failure (HP:0002878)2.53872509
52Optic disc pallor (HP:0000543)2.53216996
53Generalized aminoaciduria (HP:0002909)2.51709983
54Abnormality of the renal collecting system (HP:0004742)2.50325242
55Abnormal number of erythroid precursors (HP:0012131)2.49957916
56Capillary hemangiomas (HP:0005306)2.47076546
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45845910
58Facial hemangioma (HP:0000329)2.44842830
59Intestinal fistula (HP:0100819)2.42619110
60Type I transferrin isoform profile (HP:0003642)2.41656197
61Pancytopenia (HP:0001876)2.39510686
62Abnormality of chromosome stability (HP:0003220)2.39241194
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38587924
64Abnormality of alanine metabolism (HP:0010916)2.38587924
65Hyperalaninemia (HP:0003348)2.38587924
66Exercise intolerance (HP:0003546)2.38488882
67Cheilitis (HP:0100825)2.35988032
68Leukodystrophy (HP:0002415)2.35310372
69Methylmalonic aciduria (HP:0012120)2.35277731
70Respiratory difficulties (HP:0002880)2.32940559
71CNS demyelination (HP:0007305)2.32655926
72Abnormal respiratory epithelium morphology (HP:0012253)2.31884532
73Abnormal respiratory motile cilium morphology (HP:0005938)2.31884532
74Macrocytic anemia (HP:0001972)2.31567951
75Abnormality of cells of the erythroid lineage (HP:0012130)2.31452931
76Muscle fibrillation (HP:0010546)2.30757817
77Increased serum pyruvate (HP:0003542)2.30299416
78Abnormality of renal resorption (HP:0011038)2.29923727
79Intestinal atresia (HP:0011100)2.29013656
80Aplastic anemia (HP:0001915)2.23144338
81Increased muscle lipid content (HP:0009058)2.22534829
82Lethargy (HP:0001254)2.22503290
83Abnormality of the prostate (HP:0008775)2.22394943
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22166100
85IgG deficiency (HP:0004315)2.21783213
86Alopecia of scalp (HP:0002293)2.21726491
87Aplasia of the musculature (HP:0100854)2.19992176
88Abnormality of placental membranes (HP:0011409)2.18802134
89Amniotic constriction ring (HP:0009775)2.18802134
90Ectopic kidney (HP:0000086)2.15670700
91Vaginal fistula (HP:0004320)2.15167769
92Albinism (HP:0001022)2.14749855
93Myelodysplasia (HP:0002863)2.14049233
94Abnormality of methionine metabolism (HP:0010901)2.13825910
95Degeneration of anterior horn cells (HP:0002398)2.12258227
96Abnormality of the anterior horn cell (HP:0006802)2.12258227
97Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09687994
98Clubbing of toes (HP:0100760)2.09001714
99Hypothermia (HP:0002045)2.08815203
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06397694
101Increased hepatocellular lipid droplets (HP:0006565)2.04735572
102Microvesicular hepatic steatosis (HP:0001414)2.03746483
103Hyperglycinemia (HP:0002154)2.03640291
104Abnormality of serum amino acid levels (HP:0003112)2.01748172
105Pulmonary fibrosis (HP:0002206)2.00707595
1063-Methylglutaconic aciduria (HP:0003535)2.00431532
107Congenital, generalized hypertrichosis (HP:0004540)2.00424204
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99831305
109Colon cancer (HP:0003003)1.99185711
110Rough bone trabeculation (HP:0100670)1.98511045
111Pancreatic cysts (HP:0001737)1.97576811
112Abnormality of T cell physiology (HP:0011840)1.96921455
113Supernumerary spleens (HP:0009799)1.95447706
114Recurrent lower respiratory tract infections (HP:0002783)1.95129702
115Prostate neoplasm (HP:0100787)1.94213408
116Pendular nystagmus (HP:0012043)1.93024709
117Bone marrow hypocellularity (HP:0005528)1.93006032
118Abnormality of the labia minora (HP:0012880)1.91565109
119Short thumb (HP:0009778)1.91223786
120Medial flaring of the eyebrow (HP:0010747)1.90945556
121Hypoproteinemia (HP:0003075)1.90230604
122Lymphoma (HP:0002665)1.90058508
123Stomatitis (HP:0010280)1.89948236
124Abnormality of glycolysis (HP:0004366)1.89706818
125Popliteal pterygium (HP:0009756)1.89581053
126Triphalangeal thumb (HP:0001199)1.89385393
127Selective tooth agenesis (HP:0001592)1.88146183
128Squamous cell carcinoma (HP:0002860)1.86774954
129X-linked dominant inheritance (HP:0001423)1.86455141
130Hypoplasia of the radius (HP:0002984)1.86397295
131Abnormal hemoglobin (HP:0011902)1.86378274
132Oral leukoplakia (HP:0002745)1.85223917
133Nausea (HP:0002018)1.84407259
134Cerebral hypomyelination (HP:0006808)1.82627017
135Abnormality of the heme biosynthetic pathway (HP:0010472)1.82258310
136Hypochromic microcytic anemia (HP:0004840)1.82196868
137Abnormal lung lobation (HP:0002101)1.81841981
138Glycosuria (HP:0003076)1.80162644
139Abnormality of urine glucose concentration (HP:0011016)1.80162644
140Small intestinal stenosis (HP:0012848)1.78813745
141Duodenal stenosis (HP:0100867)1.78813745
142Renal cortical cysts (HP:0000803)1.78394741
143IgA deficiency (HP:0002720)1.78211802
144Congenital ichthyosiform erythroderma (HP:0007431)1.77798788
14511 pairs of ribs (HP:0000878)1.76614336
146Microretrognathia (HP:0000308)1.76446461
147Aplasia/hypoplasia of the uterus (HP:0008684)1.75966818
148Gonadotropin excess (HP:0000837)1.75662625
149IgM deficiency (HP:0002850)1.74982752
150Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74950242
151Hypochromic anemia (HP:0001931)1.72636151
152Abnormal trabecular bone morphology (HP:0100671)1.72423295
153Sparse eyelashes (HP:0000653)1.71135305
154Pallor (HP:0000980)1.69932921
155Constricted visual fields (HP:0001133)1.68979708
156Dicarboxylic aciduria (HP:0003215)1.68978674
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68978674
158Redundant skin (HP:0001582)1.68178594
159Neutropenia (HP:0001875)1.68055220
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67665737
161Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67665737
162Abnormality of DNA repair (HP:0003254)1.67273815
163Petechiae (HP:0000967)1.66734068
164Chronic obstructive pulmonary disease (HP:0006510)1.66511745
165Obstructive lung disease (HP:0006536)1.66511745
166Recurrent abscess formation (HP:0002722)1.65620479
167Bifid uvula (HP:0000193)1.65073565
168Aplasia/hypoplasia of the humerus (HP:0006507)1.64786447
169Male infertility (HP:0003251)1.64126797
170Septo-optic dysplasia (HP:0100842)1.63160741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.90803564
2MAP3K62.70249525
3EPHA22.39525002
4PIM22.38189075
5MAP3K112.38177527
6WEE12.35358410
7NUAK12.33585591
8MAPK152.30724172
9ICK2.28248429
10CDK82.28184320
11CDK72.19578663
12BUB12.14184016
13EIF2AK12.12853027
14YES12.09970223
15NME22.00811189
16MAP3K121.98126762
17NME11.94272094
18PINK11.90074783
19SRPK11.88067657
20TIE11.84746397
21DDR21.78777805
22TRIM281.76358363
23CHEK21.75023223
24VRK11.71179105
25STK161.68329498
26PDK21.65002834
27IRAK31.63830960
28ZAK1.62001708
29BLK1.61904262
30TLK11.60459917
31MATK1.59037959
32MKNK21.58863330
33TRPM71.58611924
34PLK41.55459718
35CDC71.55092154
36PIM11.52186778
37PLK11.49758623
38TXK1.48935371
39TAF11.47227250
40EIF2AK31.42920844
41IRAK41.41014095
42NEK11.40129788
43WNK31.38572611
44MAP4K21.38544700
45STK38L1.36309951
46ATR1.31469543
47TEC1.30525976
48TTK1.30207572
49CSK1.27166675
50BCKDK1.23669020
51FGR1.20559449
52PBK1.19663842
53FRK1.18509884
54IKBKB1.18383846
55BRSK21.18273170
56MKNK11.16569808
57DYRK31.14465618
58ACVR1B1.11507677
59AKT31.09267184
60INSRR1.08815027
61EIF2AK21.08424418
62ADRBK21.07184195
63TAOK31.02545264
64CCNB10.97324337
65MYLK0.96886690
66PRKD20.96428719
67SIK30.91519753
68MAP4K10.90491160
69GRK10.90267430
70DAPK10.89373888
71ERBB30.89281977
72CDK190.88553333
73MST40.88368711
74MAPK110.88074871
75TAOK20.83286470
76LYN0.82800324
77CSNK2A10.81252981
78MAP3K140.80702456
79PLK20.79505903
80NEK20.79308302
81AURKA0.76911537
82STK40.76859793
83BCR0.75700802
84PRPF4B0.75123192
85CDK120.74979671
86OXSR10.73424899
87AURKB0.72499689
88TNIK0.72042798
89BMX0.72031442
90ATM0.71682908
91TSSK60.69412695
92BRAF0.68362290
93MUSK0.67342203
94RPS6KA60.67073254
95CHEK10.66804125
96RPS6KC10.65374102
97RPS6KL10.65374102
98DYRK20.64655331
99RPS6KA40.62749697
100RPS6KB20.59791652
101LIMK10.59430604
102CDK90.58765434
103STK30.57160762
104PASK0.56826625
105CDK40.56177605
106NLK0.54507114
107ILK0.53612161
108UHMK10.53502296
109PAK40.53400074
110BMPR1B0.52086640
111CSNK2A20.51523376
112CLK10.51249721
113IKBKE0.50590084
114GRK70.49484205
115MAP3K50.47847326
116STK240.47406024
117CDK30.46529471
118MAP2K70.46340323
119BTK0.46282923
120ABL20.45653327
121SCYL20.45199698
122CSNK1G30.44732784
123TYK20.43953937
124RPS6KA50.42807446
125PLK30.42673666
126CDK60.42367638
127PIK3CG0.42131945
128PRKCQ0.42025532
129STK100.40743116
130JAK30.39401319
131PAK10.38451984
132BRSK10.38271913
133TESK20.37862770
134KDR0.37784876
135CDK20.37621746
136MAP3K40.36273858
137TGFBR10.35240934
138STK390.34941514
139WNK40.34604248
140BMPR20.33976960
141CSNK1G20.33940588
142KIT0.33699997
143GRK50.33417830
144CSNK1G10.32790852
145ADRBK10.32346331
146SYK0.31387849
147FLT30.30188928

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32268535
2Mismatch repair_Homo sapiens_hsa034304.26892649
3Base excision repair_Homo sapiens_hsa034103.63953798
4Homologous recombination_Homo sapiens_hsa034403.28404207
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18120095
6RNA polymerase_Homo sapiens_hsa030203.02914697
7Ribosome_Homo sapiens_hsa030102.97179368
8Fanconi anemia pathway_Homo sapiens_hsa034602.86426994
9Proteasome_Homo sapiens_hsa030502.77655480
10Spliceosome_Homo sapiens_hsa030402.69876849
11Nucleotide excision repair_Homo sapiens_hsa034202.60264317
12RNA transport_Homo sapiens_hsa030132.15290987
13Pyrimidine metabolism_Homo sapiens_hsa002402.08444287
14Cell cycle_Homo sapiens_hsa041102.06795292
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95292886
16Alzheimers disease_Homo sapiens_hsa050101.95105220
17* Basal transcription factors_Homo sapiens_hsa030221.89583318
18Non-homologous end-joining_Homo sapiens_hsa034501.87219950
19Primary immunodeficiency_Homo sapiens_hsa053401.66262061
20p53 signaling pathway_Homo sapiens_hsa041151.57821842
21RNA degradation_Homo sapiens_hsa030181.54561462
22One carbon pool by folate_Homo sapiens_hsa006701.40344104
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31671637
24mRNA surveillance pathway_Homo sapiens_hsa030151.30662705
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26576306
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.24446471
27Herpes simplex infection_Homo sapiens_hsa051681.23743817
28Collecting duct acid secretion_Homo sapiens_hsa049661.23455155
29Fatty acid elongation_Homo sapiens_hsa000621.21972973
30Propanoate metabolism_Homo sapiens_hsa006401.21873233
31Purine metabolism_Homo sapiens_hsa002301.20144947
32Graft-versus-host disease_Homo sapiens_hsa053321.10354107
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09844621
34Folate biosynthesis_Homo sapiens_hsa007901.09752385
35Allograft rejection_Homo sapiens_hsa053301.05515112
36Vitamin B6 metabolism_Homo sapiens_hsa007501.05006547
37Protein export_Homo sapiens_hsa030601.04013934
38Regulation of autophagy_Homo sapiens_hsa041401.02790275
39Pyruvate metabolism_Homo sapiens_hsa006201.01034574
40Fatty acid biosynthesis_Homo sapiens_hsa000611.00863157
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00500496
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98361156
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98311979
44Cardiac muscle contraction_Homo sapiens_hsa042600.97857927
45Epstein-Barr virus infection_Homo sapiens_hsa051690.96510317
46Measles_Homo sapiens_hsa051620.93192794
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89686186
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88355450
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88250438
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.88059433
51Huntingtons disease_Homo sapiens_hsa050160.85924315
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84994261
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83674530
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81223742
55Oxidative phosphorylation_Homo sapiens_hsa001900.80402436
56Selenocompound metabolism_Homo sapiens_hsa004500.79632924
57Arachidonic acid metabolism_Homo sapiens_hsa005900.79447151
58Sulfur metabolism_Homo sapiens_hsa009200.78968028
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78347425
60Legionellosis_Homo sapiens_hsa051340.78206297
61Nitrogen metabolism_Homo sapiens_hsa009100.77222437
62Peroxisome_Homo sapiens_hsa041460.75574905
63Sulfur relay system_Homo sapiens_hsa041220.75274865
64Notch signaling pathway_Homo sapiens_hsa043300.74797876
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74364607
66Autoimmune thyroid disease_Homo sapiens_hsa053200.73107169
67Hematopoietic cell lineage_Homo sapiens_hsa046400.72946177
68Parkinsons disease_Homo sapiens_hsa050120.69697613
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68807701
70Asthma_Homo sapiens_hsa053100.68747771
71Arginine and proline metabolism_Homo sapiens_hsa003300.67221157
72Glutathione metabolism_Homo sapiens_hsa004800.63929377
73TGF-beta signaling pathway_Homo sapiens_hsa043500.62394055
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60591610
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60348888
76Antigen processing and presentation_Homo sapiens_hsa046120.59112356
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59034077
78Shigellosis_Homo sapiens_hsa051310.58892343
79Phototransduction_Homo sapiens_hsa047440.57860968
80Circadian rhythm_Homo sapiens_hsa047100.56352858
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56138075
82Systemic lupus erythematosus_Homo sapiens_hsa053220.51111502
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51003961
84Butanoate metabolism_Homo sapiens_hsa006500.49954031
85HTLV-I infection_Homo sapiens_hsa051660.47694248
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.46778967
87Viral carcinogenesis_Homo sapiens_hsa052030.45312541
88Linoleic acid metabolism_Homo sapiens_hsa005910.45034380
89Hepatitis B_Homo sapiens_hsa051610.44806874
90Rheumatoid arthritis_Homo sapiens_hsa053230.43961402
91Type I diabetes mellitus_Homo sapiens_hsa049400.43792119
92Tryptophan metabolism_Homo sapiens_hsa003800.43354285
93Pentose phosphate pathway_Homo sapiens_hsa000300.41417950
94Carbon metabolism_Homo sapiens_hsa012000.40885173
95Oocyte meiosis_Homo sapiens_hsa041140.40801203
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40327050
97Viral myocarditis_Homo sapiens_hsa054160.39683857
98Fructose and mannose metabolism_Homo sapiens_hsa000510.38793863
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37917405
100Influenza A_Homo sapiens_hsa051640.37254897
101N-Glycan biosynthesis_Homo sapiens_hsa005100.36584689
102Metabolic pathways_Homo sapiens_hsa011000.36510356
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36494381
104Malaria_Homo sapiens_hsa051440.36121430
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.35793778
106Other glycan degradation_Homo sapiens_hsa005110.35684725
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35466695
108Apoptosis_Homo sapiens_hsa042100.35101497
109Leishmaniasis_Homo sapiens_hsa051400.34258421
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.33970678
111Hippo signaling pathway_Homo sapiens_hsa043900.32818191
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31049262
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31021568
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30807751
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30147554
116Adherens junction_Homo sapiens_hsa045200.29937744
117Caffeine metabolism_Homo sapiens_hsa002320.29839824
118Chemical carcinogenesis_Homo sapiens_hsa052040.29757699
119Olfactory transduction_Homo sapiens_hsa047400.27800582
120Vibrio cholerae infection_Homo sapiens_hsa051100.26770080
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26495203
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26424748
123Retinol metabolism_Homo sapiens_hsa008300.26064225
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.25519526
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24971063
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24501603
127Steroid biosynthesis_Homo sapiens_hsa001000.24443497
128Biosynthesis of amino acids_Homo sapiens_hsa012300.24436874
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24351608
130Wnt signaling pathway_Homo sapiens_hsa043100.23768195
131Fatty acid degradation_Homo sapiens_hsa000710.21867718
132Acute myeloid leukemia_Homo sapiens_hsa052210.21630088
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.20714527
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20643634
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20024882
136Small cell lung cancer_Homo sapiens_hsa052220.19052174
137MicroRNAs in cancer_Homo sapiens_hsa052060.18379660
138Sphingolipid metabolism_Homo sapiens_hsa006000.17495147
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17327364
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16731084

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