TAF13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.93310622
2long-chain fatty acid biosynthetic process (GO:0042759)6.32481412
3myelination (GO:0042552)5.15121372
4ensheathment of neurons (GO:0007272)5.14817840
5axon ensheathment (GO:0008366)5.14817840
6cholesterol biosynthetic process (GO:0006695)5.04959790
7protein neddylation (GO:0045116)4.83308326
8regulation of somitogenesis (GO:0014807)4.81485074
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.50967539
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.47416838
11sterol biosynthetic process (GO:0016126)4.44695488
12isoprenoid biosynthetic process (GO:0008299)4.35895804
13regulation of collateral sprouting (GO:0048670)4.23127436
14chaperone-mediated protein transport (GO:0072321)4.18218564
15limb bud formation (GO:0060174)4.17507017
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11083326
17response to redox state (GO:0051775)4.10769007
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96796568
19ATP synthesis coupled proton transport (GO:0015986)3.96796568
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.88888740
21NADH dehydrogenase complex assembly (GO:0010257)3.88888740
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88888740
23GPI anchor biosynthetic process (GO:0006506)3.82626353
24response to methylmercury (GO:0051597)3.80367625
25myelin maintenance (GO:0043217)3.77784697
26long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.74119747
27L-amino acid import (GO:0043092)3.66263453
28negative regulation of protein localization to cell surface (GO:2000009)3.65774677
29substantia nigra development (GO:0021762)3.61770991
30negative regulation of neurotransmitter transport (GO:0051589)3.59502006
31eye photoreceptor cell differentiation (GO:0001754)3.59479346
32photoreceptor cell differentiation (GO:0046530)3.59479346
33long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.57849765
34positive regulation of protein autophosphorylation (GO:0031954)3.56066224
35sphingoid metabolic process (GO:0046519)3.54897975
36nucleotide transmembrane transport (GO:1901679)3.53591224
37amyloid precursor protein metabolic process (GO:0042982)3.49169243
38preassembly of GPI anchor in ER membrane (GO:0016254)3.47613634
39GPI anchor metabolic process (GO:0006505)3.45042644
40oligodendrocyte differentiation (GO:0048709)3.43052766
41glycerophospholipid catabolic process (GO:0046475)3.41458062
42neuron remodeling (GO:0016322)3.37831307
43ribosome assembly (GO:0042255)3.36046556
44establishment of mitochondrion localization (GO:0051654)3.35852835
45respiratory electron transport chain (GO:0022904)3.35210778
46cullin deneddylation (GO:0010388)3.33856841
47ribonucleoprotein complex disassembly (GO:0032988)3.33331140
48negative regulation of execution phase of apoptosis (GO:1900118)3.31825518
49water-soluble vitamin biosynthetic process (GO:0042364)3.29470401
50positive regulation of oligodendrocyte differentiation (GO:0048714)3.27847507
51organelle disassembly (GO:1903008)3.27203740
52electron transport chain (GO:0022900)3.25244693
53magnesium ion transport (GO:0015693)3.24374598
54mannosylation (GO:0097502)3.23591171
55protein deneddylation (GO:0000338)3.21146910
56fatty-acyl-CoA metabolic process (GO:0035337)3.17920938
57import into cell (GO:0098657)3.16051288
58positive regulation of actin filament depolymerization (GO:0030836)3.06927411
59positive regulation of mitochondrial membrane permeability (GO:0035794)3.06688582
60protein complex biogenesis (GO:0070271)3.05416473
61protein targeting to mitochondrion (GO:0006626)2.99160951
62sphingosine metabolic process (GO:0006670)2.98530692
63lipid particle organization (GO:0034389)2.98448758
64negative regulation of neurotransmitter secretion (GO:0046929)2.97303727
65respiratory chain complex IV assembly (GO:0008535)2.95869690
66regulation of cellular amino acid metabolic process (GO:0006521)2.94540299
67positive regulation of cellular amine metabolic process (GO:0033240)2.94418072
68fatty-acyl-CoA biosynthetic process (GO:0046949)2.93236209
69positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.92191641
70mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.92191641
71dopamine biosynthetic process (GO:0042416)2.91865664
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88908121
73platelet dense granule organization (GO:0060155)2.88458313
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87878376
75protein localization to mitochondrion (GO:0070585)2.87531099
76cranial nerve development (GO:0021545)2.87025308
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86186710
78negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.85933377
79maturation of 5.8S rRNA (GO:0000460)2.84763249
80neurotransmitter uptake (GO:0001504)2.80849317
81establishment of protein localization to mitochondrion (GO:0072655)2.80596862
82rRNA modification (GO:0000154)2.80167951
83tissue regeneration (GO:0042246)2.79973909
84ribosomal small subunit biogenesis (GO:0042274)2.79247041
85axon development (GO:0061564)2.78972792
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77719666
87astrocyte development (GO:0014002)2.77448487
88microtubule polymerization or depolymerization (GO:0031109)2.77427767
89phosphatidylserine acyl-chain remodeling (GO:0036150)2.76885398
90otic vesicle formation (GO:0030916)2.76737807
91negative regulation of ligase activity (GO:0051352)2.75183207
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75183207
93negative regulation of acute inflammatory response (GO:0002674)2.74751491
94lateral sprouting from an epithelium (GO:0060601)2.73063321
95pseudouridine synthesis (GO:0001522)2.70846911
96very long-chain fatty acid metabolic process (GO:0000038)2.70189535
97creatine metabolic process (GO:0006600)2.69519999
98protein heterotetramerization (GO:0051290)2.68736396
99proteasome assembly (GO:0043248)2.68318603
100diol metabolic process (GO:0034311)2.67847516
101amino acid import (GO:0043090)2.66775853
102keratinocyte development (GO:0003334)2.66197186
103mitochondrial respiratory chain complex assembly (GO:0033108)2.64696140
104cell adhesion mediated by integrin (GO:0033627)2.62762898
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62643476
106response to lipoprotein particle (GO:0055094)2.62637226
107presynaptic membrane organization (GO:0097090)2.61796790
108positive regulation of pseudopodium assembly (GO:0031274)2.60040210
109negative regulation of chemokine production (GO:0032682)2.58707323
110regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.58076935
111histone H2B ubiquitination (GO:0033523)2.58012766
112ear development (GO:0043583)2.57845769
113termination of RNA polymerase III transcription (GO:0006386)2.55542021
114transcription elongation from RNA polymerase III promoter (GO:0006385)2.55542021
115enteric nervous system development (GO:0048484)2.55458022
116signal peptide processing (GO:0006465)2.55031227
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54193607
118rRNA methylation (GO:0031167)2.53989973
119positive regulation of ligase activity (GO:0051351)2.53835240
120intracellular protein transmembrane import (GO:0044743)2.53374269
121apical protein localization (GO:0045176)2.52880814
122dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.52680517
123cellular copper ion homeostasis (GO:0006878)2.52085913
124nucleotide transport (GO:0006862)2.51059033
125cerebral cortex radially oriented cell migration (GO:0021799)2.50011291
126protein palmitoylation (GO:0018345)2.49835165
127DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49770762
128neural nucleus development (GO:0048857)2.48417606
129membrane lipid biosynthetic process (GO:0046467)2.48158023
130peptidyl-cysteine modification (GO:0018198)2.47934699
131activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.45993597
132UDP-N-acetylglucosamine metabolic process (GO:0006047)2.45030516
133protein K6-linked ubiquitination (GO:0085020)2.44811801
134positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.44631391
135amyloid precursor protein catabolic process (GO:0042987)2.44458850
1367-methylguanosine mRNA capping (GO:0006370)2.43022998
137regulation of integrin-mediated signaling pathway (GO:2001044)2.42355848
138N-acetylglucosamine metabolic process (GO:0006044)2.41885507
139regulation of ubiquitin-protein transferase activity (GO:0051438)2.41609007
140signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.41496508
141signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.41496508
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.41496508
143signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.39792656
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.39792656
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39491122
146heart process (GO:0003015)2.38963708
147heart contraction (GO:0060047)2.38963708
148cytochrome complex assembly (GO:0017004)2.36246644
149regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.36205509
150regulation of ligase activity (GO:0051340)2.35100810
151protein-cofactor linkage (GO:0018065)2.35084505
152RNA capping (GO:0036260)2.34033988
1537-methylguanosine RNA capping (GO:0009452)2.34033988
154regulation of protein autophosphorylation (GO:0031952)2.33210154
155regulation of DNA endoreduplication (GO:0032875)2.31086138
156signal transduction involved in cell cycle checkpoint (GO:0072395)2.30993375
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.30939941
158amino acid salvage (GO:0043102)2.30283681
159L-methionine salvage (GO:0071267)2.30283681
160L-methionine biosynthetic process (GO:0071265)2.30283681
161cell fate commitment involved in formation of primary germ layer (GO:0060795)2.28914704
162wound healing, spreading of epidermal cells (GO:0035313)2.28892186
163signal transduction involved in DNA damage checkpoint (GO:0072422)2.28601082
164signal transduction involved in DNA integrity checkpoint (GO:0072401)2.28601082
165regulation of glomerulus development (GO:0090192)2.26188017
166peptidyl-histidine modification (GO:0018202)2.24643016
167anterior/posterior axis specification, embryo (GO:0008595)2.24155516
168ER overload response (GO:0006983)2.21640542
169hydrogen ion transmembrane transport (GO:1902600)2.20766427
170mitochondrial transport (GO:0006839)2.20230089
171protein K11-linked ubiquitination (GO:0070979)2.19902588
172negative regulation of nitric-oxide synthase activity (GO:0051001)2.19114655
173inner mitochondrial membrane organization (GO:0007007)2.15689232
174protein peptidyl-prolyl isomerization (GO:0000413)2.15017106
175response to nitrosative stress (GO:0051409)2.14293902
176axon ensheathment in central nervous system (GO:0032291)10.0850732
177central nervous system myelination (GO:0022010)10.0850732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.86891363
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.14292151
3ELK1_19687146_ChIP-ChIP_HELA_Human3.31605654
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81409544
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.67413186
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61120261
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.47725743
8TAF15_26573619_Chip-Seq_HEK293_Human2.44113641
9VDR_22108803_ChIP-Seq_LS180_Human2.42389636
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42234303
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.35287682
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33813135
13AR_21572438_ChIP-Seq_LNCaP_Human2.32457656
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.26424504
15* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.23710468
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10298348
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09338797
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.06757159
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.01059172
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88366078
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.86275180
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85155587
23ZNF274_21170338_ChIP-Seq_K562_Hela1.82024236
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.80427860
25GBX2_23144817_ChIP-Seq_PC3_Human1.78946164
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78904519
27FUS_26573619_Chip-Seq_HEK293_Human1.77372059
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74942758
29* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74131917
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73139517
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69028040
32VDR_23849224_ChIP-Seq_CD4+_Human1.68084440
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67411849
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67243956
35ER_23166858_ChIP-Seq_MCF-7_Human1.66963701
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66259673
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65869364
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65313969
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.62423446
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61570863
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59576159
42* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58312448
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57259482
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.55788076
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52890826
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51687063
47DCP1A_22483619_ChIP-Seq_HELA_Human1.48277452
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.45671416
49IRF1_19129219_ChIP-ChIP_H3396_Human1.44709346
50RNF2_27304074_Chip-Seq_NSC_Mouse1.42943677
51P300_19829295_ChIP-Seq_ESCs_Human1.40053716
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39708066
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.39577668
54* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38656150
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38573208
56* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37648102
57AR_21909140_ChIP-Seq_LNCAP_Human1.36682088
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36383906
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34874063
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34874063
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.34293612
62BRD4_25478319_ChIP-Seq_HGPS_Human1.34253293
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33493518
64CJUN_26792858_Chip-Seq_BT549_Human1.32362470
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.32222886
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32126718
67* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31842304
68* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31551862
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30923660
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30530110
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.28662603
72EWS_26573619_Chip-Seq_HEK293_Human1.28307759
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28272801
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27402163
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27353276
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.27113874
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25953521
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25337560
79MYC_18940864_ChIP-ChIP_HL60_Human1.24740465
80* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24712898
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.24656129
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24619840
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24263869
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24156441
85* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23792041
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23307700
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.22855582
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.22357607
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21999713
90TP53_18474530_ChIP-ChIP_U2OS_Human1.21909382
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.21566027
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21248322
93HTT_18923047_ChIP-ChIP_STHdh_Human1.20536673
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19102229
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19102229
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15614754
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.15553890
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15431324
99FOXP3_21729870_ChIP-Seq_TREG_Human1.14881868
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14798524
101NANOG_19829295_ChIP-Seq_ESCs_Human1.14787403
102SOX2_19829295_ChIP-Seq_ESCs_Human1.14787403
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13579065
104* GABP_19822575_ChIP-Seq_HepG2_Human1.13499471
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.13399427
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13363867
107P300_18555785_Chip-Seq_ESCs_Mouse1.13327815
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13130273
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12090426
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.11053083
111EZH2_22144423_ChIP-Seq_EOC_Human1.10272204
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09474130
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09342057
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08138376
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07851581
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.07496022
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06608249
118TRIM28_21343339_ChIP-Seq_HEK293_Human1.06536352
119SOX17_20123909_ChIP-Seq_XEN_Mouse1.05814802
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05654782
121JUN_21703547_ChIP-Seq_K562_Human1.04894480
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04524040
123RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03975948
124LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02571998
125P53_22387025_ChIP-Seq_ESCs_Mouse1.02341859
126SOX2_18555785_Chip-Seq_ESCs_Mouse1.02145008
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01899985
128THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01573674
129CDX2_22108803_ChIP-Seq_LS180_Human1.01297555
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99951524
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.99545773
132ELK1_22589737_ChIP-Seq_MCF10A_Human0.99485294
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99043894
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.98169024
135SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98152303
136KLF4_18555785_Chip-Seq_ESCs_Mouse0.98005994
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.97984036
138TTF2_22483619_ChIP-Seq_HELA_Human0.97536439
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96757510
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96625402
141NMYC_18555785_Chip-Seq_ESCs_Mouse0.96479537
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.96078446
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95922690
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93724511
145MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93610276
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93607403
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93527230
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93031700
149KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92689378
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92539205
151SMAD4_21799915_ChIP-Seq_A2780_Human0.91922271
152OCT4_18555785_Chip-Seq_ESCs_Mouse0.91711384
153EZH2_27294783_Chip-Seq_NPCs_Mouse0.91137742
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.90697693
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90125452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.26274242
2MP0003136_yellow_coat_color3.50086667
3MP0003950_abnormal_plasma_membrane3.48702279
4MP0001529_abnormal_vocalization2.98898394
5MP0003880_abnormal_central_pattern2.89221290
6MP0004381_abnormal_hair_follicle2.87499301
7MP0001346_abnormal_lacrimal_gland2.80211497
8MP0001905_abnormal_dopamine_level2.78397672
9MP0003941_abnormal_skin_development2.68622396
10MP0009780_abnormal_chondrocyte_physiolo2.66964260
11MP0008438_abnormal_cutaneous_collagen2.56415366
12MP0000383_abnormal_hair_follicle2.54044520
13MP0005451_abnormal_body_composition2.42899253
14MP0003195_calcinosis2.39524978
15MP0008260_abnormal_autophagy2.36216221
16MP0004270_analgesia2.35135734
17MP0004742_abnormal_vestibular_system2.28331886
18MP0009379_abnormal_foot_pigmentation2.28117347
19MP0005171_absent_coat_pigmentation2.20332771
20MP0006054_spinal_hemorrhage2.18668093
21MP0002837_dystrophic_cardiac_calcinosis2.15690169
22MP0010678_abnormal_skin_adnexa2.09183891
23MP0001485_abnormal_pinna_reflex2.00585804
24MP0000566_synostosis1.94018271
25MP0000647_abnormal_sebaceous_gland1.93907168
26MP0000749_muscle_degeneration1.92363514
27MP0004142_abnormal_muscle_tone1.91550905
28MP0003718_maternal_effect1.88444682
29MP0004885_abnormal_endolymph1.81038306
30MP0000372_irregular_coat_pigmentation1.80891676
31MP0005409_darkened_coat_color1.80023405
32MP0000762_abnormal_tongue_morphology1.76494432
33MP0001486_abnormal_startle_reflex1.75550896
34MP0002009_preneoplasia1.75278933
35MP0010234_abnormal_vibrissa_follicle1.69525118
36MP0009053_abnormal_anal_canal1.68929719
37MP0002272_abnormal_nervous_system1.68185123
38MP0003690_abnormal_glial_cell1.65660182
39MP0003806_abnormal_nucleotide_metabolis1.65477794
40MP0003646_muscle_fatigue1.64755475
41MP0000778_abnormal_nervous_system1.63174700
42MP0000516_abnormal_urinary_system1.61787472
43MP0005367_renal/urinary_system_phenotyp1.61787472
44MP0004272_abnormal_basement_membrane1.60592853
45MP0003634_abnormal_glial_cell1.59861767
46MP0002796_impaired_skin_barrier1.58527934
47MP0002734_abnormal_mechanical_nocicepti1.57363942
48MP0009046_muscle_twitch1.56739983
49MP0004147_increased_porphyrin_level1.56095220
50MP0005410_abnormal_fertilization1.52609354
51MP0003329_amyloid_beta_deposits1.51104251
52MP0008058_abnormal_DNA_repair1.49726809
53MP0005084_abnormal_gallbladder_morpholo1.47857202
54MP0005408_hypopigmentation1.45757208
55MP0002102_abnormal_ear_morphology1.44418349
56MP0004957_abnormal_blastocyst_morpholog1.41265889
57MP0002090_abnormal_vision1.39096338
58MP0002332_abnormal_exercise_endurance1.38962458
59MP0006036_abnormal_mitochondrial_physio1.38904473
60MP0005423_abnormal_somatic_nervous1.36481681
61MP0002163_abnormal_gland_morphology1.33910545
62MP0002064_seizures1.31021738
63MP0003938_abnormal_ear_development1.29926143
64MP0005187_abnormal_penis_morphology1.28002230
65MP0000579_abnormal_nail_morphology1.26342168
66MP0000358_abnormal_cell_content/1.26270633
67MP0004134_abnormal_chest_morphology1.24857093
68MP0004215_abnormal_myocardial_fiber1.24654132
69MP0002638_abnormal_pupillary_reflex1.24333746
70MP0001963_abnormal_hearing_physiology1.23876829
71MP0005551_abnormal_eye_electrophysiolog1.23868422
72MP0002098_abnormal_vibrissa_morphology1.23282097
73MP0001851_eye_inflammation1.23125364
74MP0005257_abnormal_intraocular_pressure1.22485819
75MP0001440_abnormal_grooming_behavior1.19918989
76MP0008789_abnormal_olfactory_epithelium1.18834911
77MP0002229_neurodegeneration1.18227476
78MP0006276_abnormal_autonomic_nervous1.17580931
79MP0005623_abnormal_meninges_morphology1.17412703
80MP0009250_abnormal_appendicular_skeleto1.16722610
81MP0001970_abnormal_pain_threshold1.16408587
82MP0005275_abnormal_skin_tensile1.15915322
83MP0003632_abnormal_nervous_system1.14335198
84MP0000569_abnormal_digit_pigmentation1.13194733
85MP0000026_abnormal_inner_ear1.11615059
86MP0002752_abnormal_somatic_nervous1.11520434
87MP0003937_abnormal_limbs/digits/tail_de1.10977975
88MP0008932_abnormal_embryonic_tissue1.09715367
89MP0002254_reproductive_system_inflammat1.09675173
90MP0002735_abnormal_chemical_nociception1.09601451
91MP0010352_gastrointestinal_tract_polyps1.08358209
92MP0000343_altered_response_to1.05443039
93MP0002282_abnormal_trachea_morphology1.03861893
94MP0001542_abnormal_bone_strength1.03533985
95MP0002876_abnormal_thyroid_physiology1.03377782
96MP0002060_abnormal_skin_morphology1.00350630
97MP0006035_abnormal_mitochondrial_morpho0.99487673
98MP0001661_extended_life_span0.99081712
99MP0001986_abnormal_taste_sensitivity0.97840812
100MP0000462_abnormal_digestive_system0.96296214
101MP0004233_abnormal_muscle_weight0.95842815
102MP0002295_abnormal_pulmonary_circulatio0.94859074
103MP0003279_aneurysm0.94599958
104MP0001340_abnormal_eyelid_morphology0.94505474
105MP0006072_abnormal_retinal_apoptosis0.93854298
106MP0002882_abnormal_neuron_morphology0.93774052
107MP0002160_abnormal_reproductive_system0.92509515
108MP0005379_endocrine/exocrine_gland_phen0.92224805
109MP0002972_abnormal_cardiac_muscle0.91421267
110MP0005195_abnormal_posterior_eye0.90758796
111MP0002938_white_spotting0.90224042
112MP0010771_integument_phenotype0.90102102
113MP0009384_cardiac_valve_regurgitation0.90062051
114MP0000613_abnormal_salivary_gland0.89950579
115MP0005620_abnormal_muscle_contractility0.87984778
116MP0005332_abnormal_amino_acid0.87926443
117MP0002751_abnormal_autonomic_nervous0.87746991
118MP0005501_abnormal_skin_physiology0.87498256
119MP0002277_abnormal_respiratory_mucosa0.87229186
120MP0000013_abnormal_adipose_tissue0.86769415
121MP0000377_abnormal_hair_follicle0.85159935
122MP0000750_abnormal_muscle_regeneration0.84958919
123MP0000427_abnormal_hair_cycle0.84638257
124MP0002177_abnormal_outer_ear0.84479761
125MP0010030_abnormal_orbit_morphology0.83648820
126MP0008569_lethality_at_weaning0.83470582
127MP0002733_abnormal_thermal_nociception0.82394389
128MP0010368_abnormal_lymphatic_system0.82158763
129MP0003631_nervous_system_phenotype0.81770262
130MP0004043_abnormal_pH_regulation0.81626257
131MP0000955_abnormal_spinal_cord0.81498453
132MP0001243_abnormal_dermal_layer0.81207801
133MP0002067_abnormal_sensory_capabilities0.80885187
134MP0001299_abnormal_eye_distance/0.80470458
135MP0005595_abnormal_vascular_smooth0.79813538
136MP0003755_abnormal_palate_morphology0.79808813
137MP0009745_abnormal_behavioral_response0.78430469
138MP0001968_abnormal_touch/_nociception0.78209501
139MP0008007_abnormal_cellular_replicative0.78091476
140MP0003123_paternal_imprinting0.77997927
141MP0001177_atelectasis0.76798924
142MP0002233_abnormal_nose_morphology0.76298399
143MP0002572_abnormal_emotion/affect_behav0.75803798
144MP0003786_premature_aging0.75695664
145MP0006082_CNS_inflammation0.75178975
146MP0002736_abnormal_nociception_after0.74672286
147MP0005197_abnormal_uvea_morphology0.74154656
148MP0001764_abnormal_homeostasis0.74063609
149MP0000467_abnormal_esophagus_morphology0.74011821
150MP0005253_abnormal_eye_physiology0.73760576
151MP0003186_abnormal_redox_activity0.73156826
152MP0003656_abnormal_erythrocyte_physiolo0.72986379
153MP0002066_abnormal_motor_capabilities/c0.72823476
154MP0003011_delayed_dark_adaptation0.72668498
155MP0001188_hyperpigmentation0.72381113
156MP0003693_abnormal_embryo_hatching0.72059666
157MP0005330_cardiomyopathy0.68596342
158MP0001293_anophthalmia0.68382850
159MP0008775_abnormal_heart_ventricle0.66712386
160MP0005503_abnormal_tendon_morphology0.66335994
161MP0010386_abnormal_urinary_bladder0.65287740
162MP0001879_abnormal_lymphatic_vessel0.64855039
163MP0002234_abnormal_pharynx_morphology0.64342380

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)6.00742531
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.01664527
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.32226583
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.32226583
5Neurofibrillary tangles (HP:0002185)3.98627930
6Peripheral hypomyelination (HP:0007182)3.81516067
7Congenital ichthyosiform erythroderma (HP:0007431)3.80743477
8Increased serum pyruvate (HP:0003542)3.69138868
9Abnormality of glycolysis (HP:0004366)3.69138868
10Anomalous pulmonary venous return (HP:0010772)3.51365006
11Acute necrotizing encephalopathy (HP:0006965)3.43347318
12Cerebral hypomyelination (HP:0006808)3.32497336
13Mitochondrial inheritance (HP:0001427)3.25751646
14Delayed gross motor development (HP:0002194)3.20323249
15Abnormality of the pulmonary veins (HP:0011718)3.19688817
16Hepatocellular necrosis (HP:0001404)3.19511715
17Segmental peripheral demyelination/remyelination (HP:0003481)2.97391726
18Abnormality of the corticospinal tract (HP:0002492)2.92715029
19Renal Fanconi syndrome (HP:0001994)2.88778351
20Sensory axonal neuropathy (HP:0003390)2.83761403
21Progressive macrocephaly (HP:0004481)2.79340034
22Leukodystrophy (HP:0002415)2.79092957
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77798577
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77798577
25Onion bulb formation (HP:0003383)2.72705796
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.72111752
27Stenosis of the external auditory canal (HP:0000402)2.71430072
28Abnormal mitochondria in muscle tissue (HP:0008316)2.71032963
29Acute encephalopathy (HP:0006846)2.70375358
30Congenital, generalized hypertrichosis (HP:0004540)2.66750242
31Abnormality of secondary sexual hair (HP:0009888)2.58702509
32Abnormality of the axillary hair (HP:0100134)2.58702509
33Increased hepatocellular lipid droplets (HP:0006565)2.57486158
34Methylmalonic aciduria (HP:0012120)2.56013867
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53575198
36Hypoplastic pelvis (HP:0008839)2.52137860
37Hepatic necrosis (HP:0002605)2.50039719
38Increased CSF lactate (HP:0002490)2.49583441
39Myelomeningocele (HP:0002475)2.48602982
40Cerebral inclusion bodies (HP:0100314)2.47938836
41Cerebral edema (HP:0002181)2.47080660
42Conical tooth (HP:0000698)2.43840570
43Retinal dysplasia (HP:0007973)2.40403263
44Aplasia involving bones of the extremities (HP:0009825)2.38089080
45Aplasia involving bones of the upper limbs (HP:0009823)2.38089080
46Aplasia of the phalanges of the hand (HP:0009802)2.38089080
47Absent septum pellucidum (HP:0001331)2.37530731
48Follicular hyperkeratosis (HP:0007502)2.37367610
49Autoamputation (HP:0001218)2.34595428
503-Methylglutaconic aciduria (HP:0003535)2.33954983
51Adrenal hypoplasia (HP:0000835)2.32582815
52Erythroderma (HP:0001019)2.32449337
53Nemaline bodies (HP:0003798)2.29967985
54Lipid accumulation in hepatocytes (HP:0006561)2.22405195
55Abnormality of the septum pellucidum (HP:0007375)2.21851266
56Abnormal auditory evoked potentials (HP:0006958)2.19733183
57Cardiovascular calcification (HP:0011915)2.18952221
58Alacrima (HP:0000522)2.18452459
59Cupped ear (HP:0000378)2.17118411
60Meningioma (HP:0002858)2.17005235
61Hypomagnesemia (HP:0002917)2.16123141
62Cerebral hemorrhage (HP:0001342)2.15431181
63Lactic acidosis (HP:0003128)2.13951213
64Delusions (HP:0000746)2.13642744
65Increased serum lactate (HP:0002151)2.13321886
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.12098084
67Abnormality of alanine metabolism (HP:0010916)2.10416342
68Hyperalaninemia (HP:0003348)2.10416342
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10416342
70Optic disc pallor (HP:0000543)2.09867431
71Exercise-induced muscle cramps (HP:0003710)2.09507239
72CNS hypomyelination (HP:0003429)2.09135442
73Aplasia/hypoplasia of the uterus (HP:0008684)2.08246744
74Exertional dyspnea (HP:0002875)2.08236691
75Muscle fiber inclusion bodies (HP:0100299)2.07814776
76Short tibia (HP:0005736)2.07225875
77Premature rupture of membranes (HP:0001788)2.06071576
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05847739
79Neoplasm of the peripheral nervous system (HP:0100007)2.05362272
80Patchy hypopigmentation of hair (HP:0011365)2.05126730
81Abnormality of the anterior horn cell (HP:0006802)2.04181853
82Degeneration of anterior horn cells (HP:0002398)2.04181853
83Conjunctival hamartoma (HP:0100780)2.03577205
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02284782
85Fused cervical vertebrae (HP:0002949)2.01303283
86Respiratory failure (HP:0002878)2.01242381
87Slow saccadic eye movements (HP:0000514)2.01207796
88Vascular calcification (HP:0004934)1.99242951
89Spastic paraparesis (HP:0002313)1.97148784
90Exercise intolerance (HP:0003546)1.96224645
91Type I transferrin isoform profile (HP:0003642)1.95765086
92Vaginal atresia (HP:0000148)1.95429085
93Mixed hearing impairment (HP:0000410)1.95275623
94Genital tract atresia (HP:0001827)1.95257121
95Irregular epiphyses (HP:0010582)1.94883337
96Abnormality of the middle phalanges of the toes (HP:0010183)1.94749984
97Abnormality of renal resorption (HP:0011038)1.94009181
98Septo-optic dysplasia (HP:0100842)1.93441480
99Lethargy (HP:0001254)1.92923248
100Split foot (HP:0001839)1.92357731
101Abnormality of methionine metabolism (HP:0010901)1.91013961
102Morphological abnormality of the inner ear (HP:0011390)1.90468131
103Ulnar claw (HP:0001178)1.90293292
104Supranuclear gaze palsy (HP:0000605)1.90137041
105Hypoplastic left heart (HP:0004383)1.90026390
106Axonal loss (HP:0003447)1.89858277
107Pancreatic fibrosis (HP:0100732)1.87986303
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87915709
109Abnormal protein N-linked glycosylation (HP:0012347)1.87915709
110Abnormal protein glycosylation (HP:0012346)1.87915709
111Abnormal glycosylation (HP:0012345)1.87915709
112Hepatosplenomegaly (HP:0001433)1.85595006
113Decreased lacrimation (HP:0000633)1.83682178
114Nasolacrimal duct obstruction (HP:0000579)1.82741187
115White forelock (HP:0002211)1.82611280
116Abnormality of placental membranes (HP:0011409)1.81580862
117Amniotic constriction ring (HP:0009775)1.81580862
118Sparse eyelashes (HP:0000653)1.81133852
119Methylmalonic acidemia (HP:0002912)1.80093612
120Hypothermia (HP:0002045)1.79755767
121Termporal pattern (HP:0011008)1.78578303
122Insidious onset (HP:0003587)1.78578303
123Reduced subcutaneous adipose tissue (HP:0003758)1.78526471
124Postnatal microcephaly (HP:0005484)1.78455143
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78286572
126Hypokinesia (HP:0002375)1.78048280
127Abnormality of serum amino acid levels (HP:0003112)1.77970141
128Anhidrosis (HP:0000970)1.76078631
129Poor suck (HP:0002033)1.75533826
130Esophageal atresia (HP:0002032)1.75445072
131Thickened helices (HP:0000391)1.75044337
132Redundant skin (HP:0001582)1.74435427
133Aplasia/Hypoplasia of the hallux (HP:0008362)1.74105378
134Ankle contracture (HP:0006466)1.72206252
135Hypoplasia of the uterus (HP:0000013)1.72140764
136Short hallux (HP:0010109)1.72127243
137X-linked dominant inheritance (HP:0001423)1.72034171
138Septate vagina (HP:0001153)1.71216680
139Concave nail (HP:0001598)1.70860171
140Fibular aplasia (HP:0002990)1.70765496
141Metaphyseal dysplasia (HP:0100255)1.70569176
142Oral leukoplakia (HP:0002745)1.70463203
143Seborrheic dermatitis (HP:0001051)1.69024213
144CNS demyelination (HP:0007305)1.68736697
145Increased intramyocellular lipid droplets (HP:0012240)1.68719445
146Spastic gait (HP:0002064)1.67106472
147Neuroendocrine neoplasm (HP:0100634)1.67086164
148Furrowed tongue (HP:0000221)1.66709329
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.66255558
150Brittle hair (HP:0002299)1.65714546
151Limb dystonia (HP:0002451)1.65553466
152Abnormality of incisor morphology (HP:0011063)1.65123329
153Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65048739
154Partial duplication of thumb phalanx (HP:0009944)1.64577527
155Stomach cancer (HP:0012126)1.64284636
156Meningocele (HP:0002435)1.64268298
157Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63627228
158Short 1st metacarpal (HP:0010034)1.63627228
159Pancreatic cysts (HP:0001737)1.63476147
160Hypoglycemic coma (HP:0001325)1.63102021
161Progressive inability to walk (HP:0002505)1.62847591
162Tongue fasciculations (HP:0001308)1.61743227
163Poor head control (HP:0002421)1.61528331
164Abnormality of glycolipid metabolism (HP:0010969)1.61379381
165Abnormality of liposaccharide metabolism (HP:0010968)1.61379381
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.61379381
167Type 1 muscle fiber predominance (HP:0003803)1.59921992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.23877717
2PBK3.64042565
3MST43.50026719
4OXSR13.34090764
5BCR3.00755600
6LIMK12.85200295
7TESK22.74558380
8MAPKAPK52.61881308
9MAP3K122.35631718
10TSSK62.29750375
11EIF2AK12.29689533
12EPHB12.28249971
13WNK42.21624802
14ERBB32.15979731
15TRIM282.15581676
16STK38L2.02002615
17PKN11.92020879
18LATS21.84794900
19DYRK21.82316768
20MET1.79023355
21CASK1.72665732
22PLK31.69171211
23CSNK1G31.66789889
24WNK31.65433832
25WEE11.54807179
26NEK11.48893672
27PDK21.47809492
28BMPR1B1.45710027
29PNCK1.45426177
30TNIK1.44079071
31MYLK1.42127870
32CSNK1A1L1.38976059
33CSNK1G11.38778743
34NEK61.36528347
35FRK1.36210773
36CDK191.34927036
37SRPK11.33467621
38ARAF1.29496259
39NME11.28803729
40STK161.27917635
41FGR1.27129471
42CSNK1G21.25496772
43BRSK21.25156351
44CAMK2B1.23896711
45ACVR1B1.23857630
46BUB11.22393269
47MUSK1.13303549
48WNK11.12295870
49MKNK11.09110572
50IRAK31.08272092
51PINK11.07452561
52NEK91.06740862
53ROCK21.06420975
54FGFR21.05257367
55UHMK11.03692373
56GRK71.00511894
57PIM20.97978559
58PLK40.97945552
59BMPR20.96421128
60SIK30.94751699
61CDC70.94360371
62ZAK0.93905190
63CAMK2D0.93874776
64STK30.92543074
65MAP4K20.90908701
66NTRK10.90848962
67TLK10.89780884
68GRK10.87551871
69VRK20.82357777
70CAMK2G0.81217308
71PLK10.80993333
72GRK50.80974817
73PRKCE0.80800943
74VRK10.79633711
75RPS6KA50.79569410
76TRPM70.79229955
77PAK40.77663640
78CAMK2A0.74120600
79DYRK1A0.74108222
80TGFBR10.73639906
81SGK4940.72849521
82SGK2230.72849521
83MAP3K90.71693699
84MARK10.71255126
85PAK20.69932032
86TTK0.69577965
87MAP2K20.69369725
88ERBB40.68584650
89PRKCG0.66198842
90PTK20.66074392
91NME20.64778652
92CLK10.61841925
93PRKCQ0.61809284
94PLK20.60655002
95MAPK150.59546200
96EIF2AK30.58000518
97MKNK20.56976206
98PAK30.56558151
99EIF2AK20.56508126
100ABL20.56401740
101CDK140.55944593
102BLK0.55368140
103FER0.55126518
104MAPK130.55023258
105MST1R0.54766292
106TIE10.53859493
107INSRR0.53325267
108CDK80.52712460
109TESK10.52287243
110PAK60.51992740
111NTRK20.50733833
112BRAF0.48680599
113DDR20.47984725
114AKT30.47511645
115EPHA20.47375985
116PRKD10.46708259
117NUAK10.45120819
118CDK30.44929761
119PRKG10.44838190
120NLK0.44771544
121MAP3K40.44413813
122YES10.44372561
123PRKCI0.44314169
124DYRK30.43658036
125CDK50.43106034
126EPHB20.43086020
127ROCK10.40408457
128KSR10.39828678
129CSNK1A10.39161404
130MOS0.39042490
131PTK2B0.38720593
132ADRBK10.38459235
133PIK3CA0.37544767
134ADRBK20.36352937
135ITK0.36001872
136STK240.35865614
137IRAK10.35477240
138CDK150.35440912
139PRKACA0.35438745
140CDK180.34395186
141OBSCN0.34324816
142PAK10.32857187
143PIK3CG0.31871969
144MAP2K70.31650604
145GSK3A0.31593145
146CDK11A0.31499030
147PHKG10.31143835
148PHKG20.31143835
149STK40.29830745

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.43121564
2Steroid biosynthesis_Homo sapiens_hsa001004.09925055
3Fatty acid elongation_Homo sapiens_hsa000624.09586742
4Oxidative phosphorylation_Homo sapiens_hsa001903.79352220
5Parkinsons disease_Homo sapiens_hsa050122.92003164
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87087723
7Ether lipid metabolism_Homo sapiens_hsa005652.81103540
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65080655
9Protein export_Homo sapiens_hsa030602.64289076
10RNA polymerase_Homo sapiens_hsa030202.46483579
11Alzheimers disease_Homo sapiens_hsa050102.35204162
12Ribosome_Homo sapiens_hsa030102.32823437
13Proteasome_Homo sapiens_hsa030502.31404592
14Sphingolipid metabolism_Homo sapiens_hsa006002.24768124
15Sulfur metabolism_Homo sapiens_hsa009202.06047191
16Vitamin B6 metabolism_Homo sapiens_hsa007502.03112263
17Huntingtons disease_Homo sapiens_hsa050161.98050298
18Linoleic acid metabolism_Homo sapiens_hsa005911.91266338
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83718786
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79971943
21Histidine metabolism_Homo sapiens_hsa003401.69194766
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66529546
23Selenocompound metabolism_Homo sapiens_hsa004501.54324757
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48334433
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36636945
26Arachidonic acid metabolism_Homo sapiens_hsa005901.36431604
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28735006
28Collecting duct acid secretion_Homo sapiens_hsa049661.21203515
29Folate biosynthesis_Homo sapiens_hsa007901.18572802
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17273519
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14206481
32RNA transport_Homo sapiens_hsa030131.14016499
33Nucleotide excision repair_Homo sapiens_hsa034201.13344092
34Cardiac muscle contraction_Homo sapiens_hsa042601.12727875
35Autoimmune thyroid disease_Homo sapiens_hsa053201.11360081
36RNA degradation_Homo sapiens_hsa030181.11134516
37Pyruvate metabolism_Homo sapiens_hsa006201.10676670
38Rheumatoid arthritis_Homo sapiens_hsa053231.09058776
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07427536
40Mineral absorption_Homo sapiens_hsa049781.05582199
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05193707
42Homologous recombination_Homo sapiens_hsa034401.04810096
43Serotonergic synapse_Homo sapiens_hsa047261.04570499
44Axon guidance_Homo sapiens_hsa043601.03704399
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02605205
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02376265
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01111706
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00966055
49Glutathione metabolism_Homo sapiens_hsa004801.00876267
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00500576
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.98887816
52p53 signaling pathway_Homo sapiens_hsa041150.94532025
53Regulation of autophagy_Homo sapiens_hsa041400.93309737
54Tryptophan metabolism_Homo sapiens_hsa003800.90147383
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90050635
56Arginine and proline metabolism_Homo sapiens_hsa003300.89240047
57Spliceosome_Homo sapiens_hsa030400.84091205
58Legionellosis_Homo sapiens_hsa051340.83879229
59* Basal transcription factors_Homo sapiens_hsa030220.83270738
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82815528
61Synaptic vesicle cycle_Homo sapiens_hsa047210.82271778
62Phototransduction_Homo sapiens_hsa047440.80504505
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75325895
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74786401
65TGF-beta signaling pathway_Homo sapiens_hsa043500.74493540
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73870244
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72695740
68Vibrio cholerae infection_Homo sapiens_hsa051100.71659929
69Mismatch repair_Homo sapiens_hsa034300.70857573
70Metabolic pathways_Homo sapiens_hsa011000.70047418
71Fanconi anemia pathway_Homo sapiens_hsa034600.67871374
72Tyrosine metabolism_Homo sapiens_hsa003500.66359657
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.65574239
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65424970
75Circadian rhythm_Homo sapiens_hsa047100.64906822
76Butanoate metabolism_Homo sapiens_hsa006500.64872527
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.62428729
78Retinol metabolism_Homo sapiens_hsa008300.61929845
79Phagosome_Homo sapiens_hsa041450.61832988
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61065573
81Vitamin digestion and absorption_Homo sapiens_hsa049770.60092854
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60044551
83One carbon pool by folate_Homo sapiens_hsa006700.59907165
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.59237155
85Non-homologous end-joining_Homo sapiens_hsa034500.55613533
86N-Glycan biosynthesis_Homo sapiens_hsa005100.55437314
87Graft-versus-host disease_Homo sapiens_hsa053320.55393556
88Chemical carcinogenesis_Homo sapiens_hsa052040.55211627
89Renal cell carcinoma_Homo sapiens_hsa052110.54546693
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54546178
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53504812
92Oocyte meiosis_Homo sapiens_hsa041140.53418658
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51627415
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51076366
95Hippo signaling pathway_Homo sapiens_hsa043900.50071409
96Glutamatergic synapse_Homo sapiens_hsa047240.49527244
97beta-Alanine metabolism_Homo sapiens_hsa004100.48551537
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47700776
99GABAergic synapse_Homo sapiens_hsa047270.47588527
100Melanoma_Homo sapiens_hsa052180.47059063
101Ras signaling pathway_Homo sapiens_hsa040140.46553219
102Allograft rejection_Homo sapiens_hsa053300.45311166
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.44547266
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43732012
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43403580
106Ovarian steroidogenesis_Homo sapiens_hsa049130.43195265
107Peroxisome_Homo sapiens_hsa041460.42850171
108Tight junction_Homo sapiens_hsa045300.41808816
109Caffeine metabolism_Homo sapiens_hsa002320.41682973
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.40684409
111Sulfur relay system_Homo sapiens_hsa041220.39245719
112Malaria_Homo sapiens_hsa051440.39013108
113Asthma_Homo sapiens_hsa053100.37227607
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36049759
115Purine metabolism_Homo sapiens_hsa002300.35187894
116Shigellosis_Homo sapiens_hsa051310.35179207
117Long-term depression_Homo sapiens_hsa047300.34646983
118Carbon metabolism_Homo sapiens_hsa012000.33997914
119Pyrimidine metabolism_Homo sapiens_hsa002400.32452615
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31389495
121Fatty acid degradation_Homo sapiens_hsa000710.30602541
122Hedgehog signaling pathway_Homo sapiens_hsa043400.29837921
123Cocaine addiction_Homo sapiens_hsa050300.28202991
124Cell cycle_Homo sapiens_hsa041100.26522662
125DNA replication_Homo sapiens_hsa030300.23475927
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23323957
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22830250
128Pancreatic secretion_Homo sapiens_hsa049720.22356839
129Dorso-ventral axis formation_Homo sapiens_hsa043200.20320025
130Propanoate metabolism_Homo sapiens_hsa006400.20216309
131Lysosome_Homo sapiens_hsa041420.19130135
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18306069
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17867236
134Phenylalanine metabolism_Homo sapiens_hsa003600.16046704
135ECM-receptor interaction_Homo sapiens_hsa045120.16020642
136Fatty acid metabolism_Homo sapiens_hsa012120.15561915
137Morphine addiction_Homo sapiens_hsa050320.14814077
138Nicotine addiction_Homo sapiens_hsa050330.14279527
139Taste transduction_Homo sapiens_hsa047420.13326269
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.12754313
141Endocytosis_Homo sapiens_hsa041440.12544813
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11077569
143African trypanosomiasis_Homo sapiens_hsa051430.08892659
144Cholinergic synapse_Homo sapiens_hsa047250.08579828

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