TAF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.37859922
2heterochromatin organization (GO:0070828)4.24523270
3regulation of translational fidelity (GO:0006450)4.21956455
4nuclear pore complex assembly (GO:0051292)4.14784009
5RNA stabilization (GO:0043489)4.14265886
6mRNA stabilization (GO:0048255)4.14265886
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.98199258
8nuclear pore organization (GO:0006999)3.93804100
9regulation of histone H3-K27 methylation (GO:0061085)3.92263296
10folic acid-containing compound biosynthetic process (GO:0009396)3.86610531
11Golgi transport vesicle coating (GO:0048200)3.74098117
12COPI coating of Golgi vesicle (GO:0048205)3.74098117
13negative regulation of erythrocyte differentiation (GO:0045647)3.71940128
14mitotic sister chromatid cohesion (GO:0007064)3.70727841
15positive regulation of histone deacetylation (GO:0031065)3.59990474
16DNA unwinding involved in DNA replication (GO:0006268)3.58480999
17regulation of NFAT protein import into nucleus (GO:0051532)3.52192756
18protein localization to kinetochore (GO:0034501)3.49045921
19negative regulation of mRNA processing (GO:0050686)3.47020779
20negative regulation of RNA splicing (GO:0033119)3.44655896
21nucleosome disassembly (GO:0006337)3.41745057
22protein-DNA complex disassembly (GO:0032986)3.41745057
23dosage compensation (GO:0007549)3.40457671
24sister chromatid segregation (GO:0000819)3.39909985
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.35038347
26glucocorticoid receptor signaling pathway (GO:0042921)3.30381733
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27527493
28negative regulation of mRNA metabolic process (GO:1903312)3.26622482
29regulation of early endosome to late endosome transport (GO:2000641)3.23575574
30focal adhesion assembly (GO:0048041)3.21650203
31cell-substrate adherens junction assembly (GO:0007045)3.21650203
32regulation of glucose import in response to insulin stimulus (GO:2001273)3.18679080
33mitotic sister chromatid segregation (GO:0000070)3.18291381
34activation of Rac GTPase activity (GO:0032863)3.17745618
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.16880721
36protein export from nucleus (GO:0006611)3.16758139
37peptidyl-lysine dimethylation (GO:0018027)3.15682245
38regulation of RNA export from nucleus (GO:0046831)3.14980788
39negative regulation of histone methylation (GO:0031061)3.14327749
40maternal placenta development (GO:0001893)3.13838092
41regulation of sister chromatid cohesion (GO:0007063)3.13303738
42formation of translation preinitiation complex (GO:0001731)3.13251061
43cellular response to epidermal growth factor stimulus (GO:0071364)3.12880130
44protein localization to endosome (GO:0036010)3.12762287
45chromatin assembly (GO:0031497)3.08344969
46NLS-bearing protein import into nucleus (GO:0006607)3.07191150
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06803438
48DNA duplex unwinding (GO:0032508)3.04160320
49pentose-phosphate shunt (GO:0006098)3.03372462
50regulation of mRNA stability (GO:0043488)3.02856292
51proline biosynthetic process (GO:0006561)3.02598464
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01494840
53DNA geometric change (GO:0032392)3.00891347
54cytoplasmic mRNA processing body assembly (GO:0033962)3.00267811
55chromosome condensation (GO:0030261)2.99219559
563-UTR-mediated mRNA stabilization (GO:0070935)2.95711059
57mitotic chromosome condensation (GO:0007076)2.95003190
58histone H3-K36 demethylation (GO:0070544)2.89758418
59mitotic nuclear envelope disassembly (GO:0007077)2.87419922
60cytoskeletal anchoring at plasma membrane (GO:0007016)2.87322916
61tetrahydrofolate metabolic process (GO:0046653)2.86226733
62protein complex localization (GO:0031503)2.85469225
63regulation of hippo signaling (GO:0035330)2.85331581
64pore complex assembly (GO:0046931)2.85102078
65protein retention in ER lumen (GO:0006621)2.84921452
66regulation of translational termination (GO:0006449)2.84510054
67trophectodermal cell differentiation (GO:0001829)2.84490938
68cellular protein complex localization (GO:0034629)2.83928690
69response to epidermal growth factor (GO:0070849)2.83416128
70regulation of cholesterol homeostasis (GO:2000188)2.83165539
71alternative mRNA splicing, via spliceosome (GO:0000380)2.82440100
72regulation of RNA stability (GO:0043487)2.80998747
73mannose metabolic process (GO:0006013)2.78298488
74positive regulation of RNA splicing (GO:0033120)2.77679694
75intracellular estrogen receptor signaling pathway (GO:0030520)2.77161762
76protein localization to microtubule (GO:0035372)2.77046653
77retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.76025299
78nuclear envelope disassembly (GO:0051081)2.74207172
79membrane disassembly (GO:0030397)2.74207172
80stress granule assembly (GO:0034063)2.73852604
81protein localization to chromosome, centromeric region (GO:0071459)2.72868604
82cell-substrate junction assembly (GO:0007044)2.72305806
83DNA replication initiation (GO:0006270)2.71334765
84positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.70879825
85cellular hyperosmotic response (GO:0071474)2.68679347
86regulation of gene silencing by RNA (GO:0060966)2.68387830
87regulation of posttranscriptional gene silencing (GO:0060147)2.68387830
88regulation of gene silencing by miRNA (GO:0060964)2.68387830
89corticosteroid receptor signaling pathway (GO:0031958)2.65865693
90histone H2B ubiquitination (GO:0033523)2.65816639
91histone H2A monoubiquitination (GO:0035518)2.64554755
92negative regulation of fatty acid biosynthetic process (GO:0045717)2.64473631
93negative regulation of sterol transport (GO:0032372)2.63454854
94negative regulation of cholesterol transport (GO:0032375)2.63454854
95positive regulation of nuclease activity (GO:0032075)2.60119999
96apoptotic process involved in morphogenesis (GO:0060561)2.59773924
97NADPH regeneration (GO:0006740)2.59345276
98activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59335987
99mitotic G1 DNA damage checkpoint (GO:0031571)2.58924588
100regulation of fatty acid beta-oxidation (GO:0031998)2.56921719
101positive regulation of protein export from nucleus (GO:0046827)2.56042189
102histone H3-K9 demethylation (GO:0033169)2.56036296
103epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55956263
104DNA strand elongation involved in DNA replication (GO:0006271)2.55200150
105one-carbon metabolic process (GO:0006730)2.55086177
106peptidyl-arginine omega-N-methylation (GO:0035247)2.52977277
107regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50901176
108positive regulation of protein deacetylation (GO:0090312)2.50463952
109positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.50396751
110glucose catabolic process (GO:0006007)2.49540563
111DNA strand elongation (GO:0022616)2.49236514
112glycine metabolic process (GO:0006544)2.49197113
113regulation of DNA endoreduplication (GO:0032875)2.48865608
114regulation of nucleobase-containing compound transport (GO:0032239)2.48786597
115regulation of histone H3-K9 methylation (GO:0051570)2.48184284
116glucose 6-phosphate metabolic process (GO:0051156)2.48058748
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.47303432
118positive regulation of SMAD protein import into nucleus (GO:0060391)2.47118130
119positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.46770735
120regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.46770735
121hippo signaling (GO:0035329)2.45408971
122DNA topological change (GO:0006265)2.45408865
123regulation of chromatin binding (GO:0035561)2.44193388
124negative regulation of cell size (GO:0045792)2.44094528
125stress fiber assembly (GO:0043149)2.43248008
126alpha-linolenic acid metabolic process (GO:0036109)2.42560142
127nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.42347973
128lysine metabolic process (GO:0006553)2.42327068
129lysine catabolic process (GO:0006554)2.42327068
130positive regulation of DNA-dependent DNA replication (GO:2000105)2.41824949
131insulin-like growth factor receptor signaling pathway (GO:0048009)2.41313866
132positive regulation of chromosome segregation (GO:0051984)2.41120275
133regulation of nuclease activity (GO:0032069)2.40795772
134positive regulation of mitotic sister chromatid separation (GO:1901970)2.40058390
135positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.40058390
136positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.40058390
137regulation of stem cell maintenance (GO:2000036)2.39863560
138embryonic retina morphogenesis in camera-type eye (GO:0060059)2.39831731
139gene silencing (GO:0016458)2.39687914
140DNA packaging (GO:0006323)2.39267979
141DNA conformation change (GO:0071103)2.39089909
142dicarboxylic acid biosynthetic process (GO:0043650)2.36855382
143paraxial mesoderm development (GO:0048339)2.35534724
144positive regulation of gene expression, epigenetic (GO:0045815)2.35413487
145gene silencing by RNA (GO:0031047)2.34627505
146adherens junction assembly (GO:0034333)2.33094457
147regulation of mitotic spindle organization (GO:0060236)2.31993389
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.31276755
149regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.29787993
150regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.28829448
151mitotic G1/S transition checkpoint (GO:0044819)2.28072045
152embryonic process involved in female pregnancy (GO:0060136)2.27860800
153establishment of apical/basal cell polarity (GO:0035089)2.27462459
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.27172013
155negative regulation of fibrinolysis (GO:0051918)2.27169903
156embryonic placenta development (GO:0001892)2.27121540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.49351696
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.84768344
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.02534307
4MYC_22102868_ChIP-Seq_BL_Human3.79923659
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.49979198
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.81586747
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.28259455
8VDR_21846776_ChIP-Seq_THP-1_Human2.27778719
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21327179
10TCF7_22412390_ChIP-Seq_EML_Mouse2.17363327
11* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14500196
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13595144
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10016516
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06340417
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05966408
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99251663
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.98825921
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93767076
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93077697
20KDM2B_26808549_Chip-Seq_DND41_Human1.92777757
21CLOCK_20551151_ChIP-Seq_293T_Human1.89248350
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76292410
23AR_21909140_ChIP-Seq_LNCAP_Human1.74363532
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.73232970
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67376340
26* MYC_18555785_ChIP-Seq_MESCs_Mouse1.66584383
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65509736
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65018316
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60439896
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59934042
31UTX_26944678_Chip-Seq_JUKART_Human1.58903946
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.58200483
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.57643169
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56503905
35MAF_26560356_Chip-Seq_TH1_Human1.54723006
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53890530
37KDM2B_26808549_Chip-Seq_K562_Human1.51394888
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51139475
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46901060
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46549339
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43595939
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43257142
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43155652
44ZNF263_19887448_ChIP-Seq_K562_Human1.41441463
45NCOR1_26117541_ChIP-Seq_K562_Human1.39117603
46ATF3_27146783_Chip-Seq_COLON_Human1.38414615
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37929327
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34039490
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29731205
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29465281
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.29433972
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29087366
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28778850
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28050141
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27855300
56RACK7_27058665_Chip-Seq_MCF-7_Human1.27847673
57CIITA_25753668_ChIP-Seq_RAJI_Human1.26432410
58LXR_22292898_ChIP-Seq_THP-1_Human1.25828832
59* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24486436
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22906980
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22465023
62KDM5A_27292631_Chip-Seq_BREAST_Human1.21808504
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20723706
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20424409
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20361553
66GATA6_25053715_ChIP-Seq_YYC3_Human1.20059301
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19720287
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17917902
69CHD1_26751641_Chip-Seq_LNCaP_Human1.17739528
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17568878
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15749374
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15448024
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14825549
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14803945
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13826269
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13331407
77MYB_26560356_Chip-Seq_TH1_Human1.13182974
78VDR_24763502_ChIP-Seq_THP-1_Human1.13063790
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12706094
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.12335697
81* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12325484
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11624707
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09447920
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09421629
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09151121
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08174188
87XRN2_22483619_ChIP-Seq_HELA_Human1.07745772
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.07222529
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05998264
90* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05654141
91* P68_20966046_ChIP-Seq_HELA_Human1.04085084
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03620937
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03452140
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03451692
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.02027999
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01879791
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01705937
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01637658
99SCL_19346495_ChIP-Seq_HPC-7_Human1.01160823
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01050750
101SMC4_20622854_ChIP-Seq_HELA_Human1.01042591
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.00997570
103CREB1_26743006_Chip-Seq_LNCaP_Human1.00599818
104MYB_26560356_Chip-Seq_TH2_Human0.99438543
105MAF_26560356_Chip-Seq_TH2_Human0.98840535
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97866665
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97866665
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97866665
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97592880
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97435914
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.97101394
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96880507
113UBF1/2_26484160_Chip-Seq_HMECs_Human0.96409524
114* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96142894
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96084297
116PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95812508
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95079988
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95044130
119TP53_22127205_ChIP-Seq_IMR90_Human0.94628161
120* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94590372
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.94323498
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94236573
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93704008
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.93292469
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92526291
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91808484
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91788224
128* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90834959
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.89220522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.20725283
2MP0010352_gastrointestinal_tract_polyps3.04976574
3MP0005076_abnormal_cell_differentiation3.02410339
4MP0005451_abnormal_body_composition2.90105553
5MP0005360_urolithiasis2.56204647
6MP0002139_abnormal_hepatobiliary_system2.45843960
7MP0003111_abnormal_nucleus_morphology2.10745460
8MP0003300_gastrointestinal_ulcer2.09715367
9MP0009053_abnormal_anal_canal2.08295677
10MP0010234_abnormal_vibrissa_follicle1.98382604
11MP0010307_abnormal_tumor_latency1.97401036
12MP0005365_abnormal_bile_salt1.94008345
13MP0005085_abnormal_gallbladder_physiolo1.93887382
14MP0003566_abnormal_cell_adhesion1.93569863
15MP0009278_abnormal_bone_marrow1.88507377
16MP0004197_abnormal_fetal_growth/weight/1.88028078
17MP0004858_abnormal_nervous_system1.86531801
18MP0001730_embryonic_growth_arrest1.78868269
19MP0001849_ear_inflammation1.77876066
20MP0003252_abnormal_bile_duct1.76950266
21MP0000678_abnormal_parathyroid_gland1.74160194
22MP0010094_abnormal_chromosome_stability1.70881573
23MP0002796_impaired_skin_barrier1.70706236
24MP0003077_abnormal_cell_cycle1.70566748
25MP0004957_abnormal_blastocyst_morpholog1.69891130
26MP0002009_preneoplasia1.66941807
27MP0005409_darkened_coat_color1.63389494
28MP0002396_abnormal_hematopoietic_system1.61294261
29MP0000569_abnormal_digit_pigmentation1.61225055
30MP0001348_abnormal_lacrimal_gland1.60734164
31MP0000350_abnormal_cell_proliferation1.59749645
32MP0005380_embryogenesis_phenotype1.59725113
33MP0001672_abnormal_embryogenesis/_devel1.59725113
34MP0003984_embryonic_growth_retardation1.59308127
35MP0002086_abnormal_extraembryonic_tissu1.58937698
36MP0002088_abnormal_embryonic_growth/wei1.58715873
37MP0004185_abnormal_adipocyte_glucose1.56474004
38MP0000733_abnormal_muscle_development1.55131877
39MP0004264_abnormal_extraembryonic_tissu1.50694907
40MP0002084_abnormal_developmental_patter1.50588302
41MP0003303_peritoneal_inflammation1.47503494
42MP0003693_abnormal_embryo_hatching1.46204779
43MP0004808_abnormal_hematopoietic_stem1.42551638
44MP0008932_abnormal_embryonic_tissue1.38238549
45MP0009672_abnormal_birth_weight1.38131063
46MP0005023_abnormal_wound_healing1.37189055
47MP0003123_paternal_imprinting1.34844441
48MP0003806_abnormal_nucleotide_metabolis1.34589014
49MP0010030_abnormal_orbit_morphology1.33391662
50MP0008961_abnormal_basal_metabolism1.32463139
51MP0001697_abnormal_embryo_size1.32356734
52MP0002877_abnormal_melanocyte_morpholog1.30813590
53MP0008057_abnormal_DNA_replication1.28634289
54MP0002085_abnormal_embryonic_tissue1.28234138
55MP0000858_altered_metastatic_potential1.27213627
56MP0005058_abnormal_lysosome_morphology1.25914485
57MP0005257_abnormal_intraocular_pressure1.25594979
58MP0002060_abnormal_skin_morphology1.23718454
59MP0000537_abnormal_urethra_morphology1.23094835
60MP0002080_prenatal_lethality1.22130492
61MP0002249_abnormal_larynx_morphology1.21719143
62MP0005621_abnormal_cell_physiology1.21407942
63MP0010329_abnormal_lipoprotein_level1.21007331
64MP0003567_abnormal_fetal_cardiomyocyte1.20714804
65MP0003453_abnormal_keratinocyte_physiol1.20401412
66MP0008260_abnormal_autophagy1.16736979
67MP0009840_abnormal_foam_cell1.15453089
68MP0008007_abnormal_cellular_replicative1.12616438
69MP0005083_abnormal_biliary_tract1.12504179
70MP0000609_abnormal_liver_physiology1.11215273
71MP0009703_decreased_birth_body1.10369060
72MP0001915_intracranial_hemorrhage1.10121352
73MP0003115_abnormal_respiratory_system1.09240111
74MP0000579_abnormal_nail_morphology1.07115787
75MP0003763_abnormal_thymus_physiology1.05558108
76MP0001545_abnormal_hematopoietic_system1.05482184
77MP0005397_hematopoietic_system_phenotyp1.05482184
78MP0002697_abnormal_eye_size1.05142612
79MP0000003_abnormal_adipose_tissue1.04216713
80MP0005666_abnormal_adipose_tissue1.02209291
81MP0000566_synostosis1.00066376
82MP0010630_abnormal_cardiac_muscle0.99699357
83MP0001346_abnormal_lacrimal_gland0.99425939
84MP0004272_abnormal_basement_membrane0.98589115
85MP0002092_abnormal_eye_morphology0.97512964
86MP0002925_abnormal_cardiovascular_devel0.97148123
87MP0003890_abnormal_embryonic-extraembry0.96506600
88MP0004087_abnormal_muscle_fiber0.95972542
89MP0003121_genomic_imprinting0.95292470
90MP0004782_abnormal_surfactant_physiolog0.94994464
91MP0001216_abnormal_epidermal_layer0.94395078
92MP0000598_abnormal_liver_morphology0.93031769
93MP0000428_abnormal_craniofacial_morphol0.92698481
94MP0003119_abnormal_digestive_system0.91063284
95MP0002019_abnormal_tumor_incidence0.89818963
96MP0003315_abnormal_perineum_morphology0.89563640
97MP0006054_spinal_hemorrhage0.87956294
98MP0000751_myopathy0.87682172
99MP0000759_abnormal_skeletal_muscle0.86952352
100MP0005384_cellular_phenotype0.86847944
101MP0009333_abnormal_splenocyte_physiolog0.86105848
102MP0000747_muscle_weakness0.86085334
103MP0000490_abnormal_crypts_of0.85991667
104MP0009931_abnormal_skin_appearance0.85724208
105MP0004233_abnormal_muscle_weight0.84550070
106MP0000703_abnormal_thymus_morphology0.84540680
107MP0004947_skin_inflammation0.84446723
108MP0003091_abnormal_cell_migration0.84434032
109MP0003221_abnormal_cardiomyocyte_apopto0.84314027
110MP0002166_altered_tumor_susceptibility0.83111298
111MP0008770_decreased_survivor_rate0.82919980
112MP0003283_abnormal_digestive_organ0.82222363
113MP0003191_abnormal_cellular_cholesterol0.81833765
114MP0005623_abnormal_meninges_morphology0.81617825
115MP0000762_abnormal_tongue_morphology0.80441700
116MP0002653_abnormal_ependyma_morphology0.79522859
117MP0000266_abnormal_heart_morphology0.77922690
118MP0008875_abnormal_xenobiotic_pharmacok0.77893887
119MP0001661_extended_life_span0.77603316
120MP0000477_abnormal_intestine_morphology0.75939316
121MP0002970_abnormal_white_adipose0.75832810
122MP0001293_anophthalmia0.75639950
123MP0000377_abnormal_hair_follicle0.75480066
124MP0000313_abnormal_cell_death0.75466747
125MP0001666_abnormal_nutrient_absorption0.75038974
126MP0005375_adipose_tissue_phenotype0.74222262
127MP0002398_abnormal_bone_marrow0.72619368
128MP0003448_altered_tumor_morphology0.72142703
129MP0008438_abnormal_cutaneous_collagen0.71249524
130MP0003385_abnormal_body_wall0.70683776
131MP0002111_abnormal_tail_morphology0.70131330
132MP0003935_abnormal_craniofacial_develop0.69851151
133MP0005319_abnormal_enzyme/_coenzyme0.68961883
134MP0000432_abnormal_head_morphology0.68560362
135MP0002722_abnormal_immune_system0.67705054
136MP0002089_abnormal_postnatal_growth/wei0.65979642
137MP0002928_abnormal_bile_duct0.65871119
138MP0005501_abnormal_skin_physiology0.64896127

Predicted human phenotypes

RankGene SetZ-score
1Pseudobulbar signs (HP:0002200)3.40802332
2Hyperacusis (HP:0010780)3.26471540
3Deep venous thrombosis (HP:0002625)2.90229450
4Ulnar bowing (HP:0003031)2.71713579
5Cerebral aneurysm (HP:0004944)2.66278643
6Ependymoma (HP:0002888)2.63056312
7Increased nuchal translucency (HP:0010880)2.62929815
8Abnormality of the fingertips (HP:0001211)2.54364844
9Obstructive sleep apnea (HP:0002870)2.51855076
10Spastic diplegia (HP:0001264)2.49821283
11Shallow orbits (HP:0000586)2.46969047
12Renovascular hypertension (HP:0100817)2.45578349
13Flat acetabular roof (HP:0003180)2.44130148
14Long palpebral fissure (HP:0000637)2.43697112
15Volvulus (HP:0002580)2.41323551
16Broad face (HP:0000283)2.40298148
17Renal duplication (HP:0000075)2.38127713
18Abnormality of the astrocytes (HP:0100707)2.35169132
19Astrocytoma (HP:0009592)2.35169132
20Back pain (HP:0003418)2.35119734
21Abnormality of the lower motor neuron (HP:0002366)2.34616047
22Centrally nucleated skeletal muscle fibers (HP:0003687)2.34137536
23Macroorchidism (HP:0000053)2.33657980
24Hypochromic microcytic anemia (HP:0004840)2.30660287
25Increased density of long bones (HP:0006392)2.30256049
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29820868
27Short 4th metacarpal (HP:0010044)2.29820868
28Rectal prolapse (HP:0002035)2.29080772
29Asymmetry of the thorax (HP:0001555)2.28827709
30Achilles tendon contracture (HP:0001771)2.27780239
31Increased mean platelet volume (HP:0011877)2.27003412
32Progressive muscle weakness (HP:0003323)2.26965801
33Heterotopia (HP:0002282)2.25932768
34Distal lower limb amyotrophy (HP:0008944)2.24909066
35Elfin facies (HP:0004428)2.24705917
36Abnormality of the calcaneus (HP:0008364)2.18406709
37Protrusio acetabuli (HP:0003179)2.17727375
38Deviation of the thumb (HP:0009603)2.16747640
39Abnormality of the distal phalanx of the thumb (HP:0009617)2.14701537
40Abnormal platelet volume (HP:0011876)2.14495428
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13889561
42Premature rupture of membranes (HP:0001788)2.12794838
43Abnormality of oral frenula (HP:0000190)2.12529937
44Subacute progressive viral hepatitis (HP:0006572)2.08981893
45Deep palmar crease (HP:0006191)2.08907444
46Mitral valve prolapse (HP:0001634)2.08890436
47Abnormality of the 4th metacarpal (HP:0010012)2.07909742
48Proximal placement of thumb (HP:0009623)2.07227524
49Fragile skin (HP:0001030)2.04205789
50Aneurysm (HP:0002617)2.03672089
51Abnormality of the thoracic spine (HP:0100711)2.02688759
52Malignant gastrointestinal tract tumors (HP:0006749)2.02269905
53Gastrointestinal carcinoma (HP:0002672)2.02269905
54High pitched voice (HP:0001620)1.99514710
55Distal upper limb amyotrophy (HP:0007149)1.97925062
56Upper limb amyotrophy (HP:0009129)1.97925062
57Sparse lateral eyebrow (HP:0005338)1.97590621
58Long eyelashes (HP:0000527)1.96797467
59Hand muscle atrophy (HP:0009130)1.93920574
60Genu recurvatum (HP:0002816)1.91866291
61Progressive external ophthalmoplegia (HP:0000590)1.89090272
62Hypobetalipoproteinemia (HP:0003563)1.86345372
63Patellar dislocation (HP:0002999)1.86345165
64Intrahepatic cholestasis (HP:0001406)1.86152292
65Trismus (HP:0000211)1.85022741
66Broad thumb (HP:0011304)1.83594426
67Disproportionate tall stature (HP:0001519)1.83271328
68Lymphangioma (HP:0100764)1.82763733
69Reticulocytosis (HP:0001923)1.82273011
70Vertebral compression fractures (HP:0002953)1.82271389
71Abnormality of the peritoneum (HP:0002585)1.82242092
72Myocardial infarction (HP:0001658)1.81931257
73Advanced eruption of teeth (HP:0006288)1.81297601
74Insomnia (HP:0100785)1.80727131
75Skin tags (HP:0010609)1.79471955
76Abnormality of the salivary glands (HP:0010286)1.79342681
77Bowel diverticulosis (HP:0005222)1.77899624
78Obsessive-compulsive behavior (HP:0000722)1.76620115
79Biliary tract neoplasm (HP:0100574)1.76113696
80Basal cell carcinoma (HP:0002671)1.75800856
81Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75728123
82Abnormal gallbladder physiology (HP:0012438)1.75700536
83Cholecystitis (HP:0001082)1.75700536
84Syringomyelia (HP:0003396)1.75366039
85Spinal cord lesions (HP:0100561)1.75366039
86Enlarged penis (HP:0000040)1.74990816
87Insidious onset (HP:0003587)1.74807781
88Termporal pattern (HP:0011008)1.74807781
89Urethral obstruction (HP:0000796)1.74700897
90Hallux valgus (HP:0001822)1.74262614
91Arnold-Chiari malformation (HP:0002308)1.74107380
92Thoracic kyphosis (HP:0002942)1.73500295
93Deviation of the hallux (HP:0010051)1.72403032
94Biconcave vertebral bodies (HP:0004586)1.71994990
95Thin ribs (HP:0000883)1.71736243
96Selective tooth agenesis (HP:0001592)1.71564485
97Bowel incontinence (HP:0002607)1.71286415
98Cutis marmorata (HP:0000965)1.71276022
99Broad palm (HP:0001169)1.70972735
100Turricephaly (HP:0000262)1.70895248
101Abnormality of the phalanges of the hallux (HP:0010057)1.70124614
102Vertebral clefting (HP:0008428)1.69495312
103Overriding aorta (HP:0002623)1.68833188
104Dysmetric saccades (HP:0000641)1.67646861
105Skull defect (HP:0001362)1.67325692
106Aortic aneurysm (HP:0004942)1.66653388
107Lower limb amyotrophy (HP:0007210)1.65926654
108Persistence of primary teeth (HP:0006335)1.65788332
109Metaphyseal cupping (HP:0003021)1.65539282
110Abnormality of the Achilles tendon (HP:0005109)1.65468952
111Deep philtrum (HP:0002002)1.64226274
112Xanthomatosis (HP:0000991)1.63754863
113Cortical dysplasia (HP:0002539)1.63189195
114Abnormality of the diencephalon (HP:0010662)1.62726155
115Abnormality of sulfur amino acid metabolism (HP:0004339)1.62469641
116Increased variability in muscle fiber diameter (HP:0003557)1.62386202
117Bladder diverticulum (HP:0000015)1.62180105
118Hammertoe (HP:0001765)1.62048359
119Mitral regurgitation (HP:0001653)1.61629975
120Hypochromic anemia (HP:0001931)1.61157678
121Increased connective tissue (HP:0009025)1.61063802
122High anterior hairline (HP:0009890)1.60340251
123Calcaneovalgus deformity (HP:0001848)1.60263103
124Vertebral arch anomaly (HP:0008438)1.59877478
125Abnormality of skeletal muscle fiber size (HP:0012084)1.59244643
126Esophageal varix (HP:0002040)1.59207147
127Uterine leiomyosarcoma (HP:0002891)1.58310987
128Leiomyosarcoma (HP:0100243)1.58310987
129Premature skin wrinkling (HP:0100678)1.57995480
130Bowing of the arm (HP:0006488)1.57711442
131Bowed forearm bones (HP:0003956)1.57711442
132Rib fusion (HP:0000902)1.56985510
133Thin bony cortex (HP:0002753)1.56738057
134Abnormal large intestine physiology (HP:0012700)1.56664227
135Overlapping toe (HP:0001845)1.56306180
136Orthostatic hypotension (HP:0001278)1.56254678
137Fibroma (HP:0010614)1.56172999
138Pointed chin (HP:0000307)1.55465393
139Fibrous tissue neoplasm (HP:0012316)1.55439427
140Flat cornea (HP:0007720)1.54912214
141Unilateral renal agenesis (HP:0000122)1.54906653
142Polygenic inheritance (HP:0010982)1.54579473
143Dilatation of the ascending aorta (HP:0005111)1.54151034
144Ankyloglossia (HP:0010296)1.53669083
145Relative macrocephaly (HP:0004482)1.53653720
146Spina bifida occulta (HP:0003298)1.53405346
147Prominent nose (HP:0000448)1.53123639
148Broad distal phalanx of finger (HP:0009836)1.52930525
149Large earlobe (HP:0009748)1.52615981
150Cerebral inclusion bodies (HP:0100314)1.52572372
151Neoplasm of striated muscle (HP:0009728)1.52090156
152Trigonocephaly (HP:0000243)1.51750865
153Glioma (HP:0009733)1.51689016
154Transitional cell carcinoma of the bladder (HP:0006740)1.51681853
155Uterine neoplasm (HP:0010784)1.51613082
156Precocious puberty (HP:0000826)1.51262213
157Segmental peripheral demyelination/remyelination (HP:0003481)1.51150548
158Natal tooth (HP:0000695)1.50185560
159Germ cell neoplasia (HP:0100728)1.49397419
160Progressive hearing impairment (HP:0001730)1.48995583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.72647964
2EEF2K3.86062708
3SMG13.82967513
4PKN23.54779923
5TRIB33.51012796
6MAP3K103.37855620
7PRPF4B3.07557378
8CDC72.25782050
9ERN12.22102032
10NEK22.20430779
11SIK12.04514302
12MAP3K131.92425412
13NEK11.92032162
14ICK1.81615437
15IRAK31.80690740
16ALK1.78199116
17PTK61.74355949
18CDK61.70407661
19LATS11.69163738
20STK101.64991547
21RPS6KB21.59392007
22BRD41.58987397
23MST1R1.57840617
24PDGFRA1.53476294
25CDK41.53316098
26SIK21.53261677
27TTN1.52531768
28CAMK1D1.52003286
29MTOR1.46373114
30MAP4K11.41008117
31BMX1.39947583
32LRRK21.35739327
33RIPK11.35437673
34CAMK1G1.33916445
35GRK61.32199262
36KSR21.31761562
37MAP3K141.15480468
38NME21.15458903
39PAK41.15115994
40STK31.07865886
41TTK1.06252003
42MAP3K91.05708770
43FGFR41.04200246
44EPHA21.04194865
45PRKD31.04049192
46PAK21.00151839
47CDK70.97806558
48PASK0.94439163
49CHEK10.93799090
50MAP3K80.93508324
51TYRO30.86204054
52TAOK10.85677337
53NTRK10.85190972
54FLT30.85182662
55PDGFRB0.84671127
56DDR20.84276134
57SCYL20.83303602
58FGFR30.83224062
59MAP2K30.82314934
60ARAF0.78737187
61MAP3K70.78309297
62ATR0.78165524
63RIPK40.78018357
64FGFR10.77919542
65RPS6KA40.76205744
66MAPK110.75527581
67LATS20.74557059
68TAOK20.72413219
69PIM10.71543514
70EIF2AK10.70365311
71CSK0.69244414
72CDK20.68773307
73MARK20.68738367
74PTK20.68273146
75MAP3K10.66101176
76BRAF0.65859522
77CLK10.65830585
78MKNK10.64974573
79ATM0.63252435
80AURKB0.62878617
81MET0.60565154
82HIPK20.58527049
83SIK30.58469467
84PRKD20.58325604
85STK40.56586097
86DYRK1B0.55531685
87MAP2K20.55112665
88CSNK1D0.52922733
89PDPK10.52806496
90TGFBR10.52509668
91CHUK0.52073027
92DMPK0.51209904
93CSNK1E0.50635118
94MOS0.49384320
95AKT20.49002362
96ITK0.48602246
97IRAK20.48542684
98CSF1R0.48345698
99TAOK30.47300553
100CDK90.46804236
101SRPK10.46363624
102RPS6KA10.46054208
103RPS6KL10.45480565
104RPS6KC10.45480565
105RET0.45199508
106TAF10.45186717
107PLK10.44979490
108CHEK20.44883761
109MAPK100.44281794
110TSSK60.43779688
111CDK80.43659409
112MAPK140.43570432
113WNK10.42995552
114CDK10.42441586
115HCK0.42015204
116IRAK40.41699460
117ZAP700.41341194
118FGFR20.41300010
119PRKDC0.40990459
120MAPK10.40598589
121JAK30.40447531
122CDK11A0.40161634
123EGFR0.39954301
124MKNK20.39062263
125ERBB20.38770297
126JAK20.38210390
127YES10.37711912
128TRPM70.37312313
129RPS6KA20.37107232
130AKT10.36476879
131BTK0.36409548
132KSR10.35839655
133PRKCH0.35754794
134CDC42BPA0.35136000
135TGFBR20.34789414
136CDK150.34733963
137SGK30.34703115
138BRSK10.34441541
139EPHB10.34273304
140JAK10.33884704
141EPHB20.33846321
142MELK0.33510625

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68381193
2One carbon pool by folate_Homo sapiens_hsa006702.61783890
3Nitrogen metabolism_Homo sapiens_hsa009102.55569288
4Lysine degradation_Homo sapiens_hsa003102.51863579
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23054817
6Arginine biosynthesis_Homo sapiens_hsa002201.95730191
7Primary bile acid biosynthesis_Homo sapiens_hsa001201.78129870
8Chronic myeloid leukemia_Homo sapiens_hsa052201.70122631
9Selenocompound metabolism_Homo sapiens_hsa004501.68951596
10mRNA surveillance pathway_Homo sapiens_hsa030151.54189430
11Biosynthesis of amino acids_Homo sapiens_hsa012301.46817862
12Renal cell carcinoma_Homo sapiens_hsa052111.46318964
13mTOR signaling pathway_Homo sapiens_hsa041501.45893933
14Prion diseases_Homo sapiens_hsa050201.44487915
15Tryptophan metabolism_Homo sapiens_hsa003801.39943916
16RNA transport_Homo sapiens_hsa030131.35755706
17Spliceosome_Homo sapiens_hsa030401.34577335
18MicroRNAs in cancer_Homo sapiens_hsa052061.32995849
19Small cell lung cancer_Homo sapiens_hsa052221.29950066
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28953403
21Other glycan degradation_Homo sapiens_hsa005111.27626865
22Bladder cancer_Homo sapiens_hsa052191.26723166
23Notch signaling pathway_Homo sapiens_hsa043301.24696315
24Non-small cell lung cancer_Homo sapiens_hsa052231.22130235
25ErbB signaling pathway_Homo sapiens_hsa040121.20210187
26Caffeine metabolism_Homo sapiens_hsa002321.19639750
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18874439
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.17150036
29Fructose and mannose metabolism_Homo sapiens_hsa000511.17022730
30Complement and coagulation cascades_Homo sapiens_hsa046101.16681360
31Adherens junction_Homo sapiens_hsa045201.15532070
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15529579
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.11726232
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11251945
35Fatty acid degradation_Homo sapiens_hsa000711.10887311
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10637330
37Proteoglycans in cancer_Homo sapiens_hsa052051.10445919
38Cell cycle_Homo sapiens_hsa041101.07922004
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06750825
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04067512
41Insulin resistance_Homo sapiens_hsa049311.03926656
42PPAR signaling pathway_Homo sapiens_hsa033200.98759110
43Acute myeloid leukemia_Homo sapiens_hsa052210.98362526
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96866711
45DNA replication_Homo sapiens_hsa030300.95173722
46B cell receptor signaling pathway_Homo sapiens_hsa046620.92908249
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92058423
48Bile secretion_Homo sapiens_hsa049760.91006198
49Carbon metabolism_Homo sapiens_hsa012000.89810617
50Estrogen signaling pathway_Homo sapiens_hsa049150.89539612
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.88040821
52HTLV-I infection_Homo sapiens_hsa051660.88032699
53Endometrial cancer_Homo sapiens_hsa052130.87732674
54Choline metabolism in cancer_Homo sapiens_hsa052310.86796492
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86660434
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86543287
57Pancreatic cancer_Homo sapiens_hsa052120.85564477
58Staphylococcus aureus infection_Homo sapiens_hsa051500.84696628
59Thyroid cancer_Homo sapiens_hsa052160.83893375
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83528035
61Hepatitis C_Homo sapiens_hsa051600.83524418
62GnRH signaling pathway_Homo sapiens_hsa049120.82668787
63Antigen processing and presentation_Homo sapiens_hsa046120.82294727
64Viral myocarditis_Homo sapiens_hsa054160.81563210
65Mismatch repair_Homo sapiens_hsa034300.80258655
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80114414
67Colorectal cancer_Homo sapiens_hsa052100.78610412
68Basal cell carcinoma_Homo sapiens_hsa052170.78230087
69Influenza A_Homo sapiens_hsa051640.78014981
70Long-term potentiation_Homo sapiens_hsa047200.76848625
71Focal adhesion_Homo sapiens_hsa045100.76438542
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.76095532
73Fat digestion and absorption_Homo sapiens_hsa049750.75357786
74Shigellosis_Homo sapiens_hsa051310.74582769
75Prostate cancer_Homo sapiens_hsa052150.73840473
76Hippo signaling pathway_Homo sapiens_hsa043900.73624009
77Viral carcinogenesis_Homo sapiens_hsa052030.73490839
78Glioma_Homo sapiens_hsa052140.73345558
79AMPK signaling pathway_Homo sapiens_hsa041520.73178157
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.72301139
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.71255524
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70669429
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70418355
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67951587
85p53 signaling pathway_Homo sapiens_hsa041150.67252807
86Measles_Homo sapiens_hsa051620.66439617
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.65741059
88Base excision repair_Homo sapiens_hsa034100.65725119
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65634040
90Fatty acid metabolism_Homo sapiens_hsa012120.65439753
91Galactose metabolism_Homo sapiens_hsa000520.65244798
92Epstein-Barr virus infection_Homo sapiens_hsa051690.64994602
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64810609
94Hepatitis B_Homo sapiens_hsa051610.64374179
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64062244
96* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63336576
97Starch and sucrose metabolism_Homo sapiens_hsa005000.63228312
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62654098
99Pathways in cancer_Homo sapiens_hsa052000.62497984
100FoxO signaling pathway_Homo sapiens_hsa040680.62088763
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61792803
102Inositol phosphate metabolism_Homo sapiens_hsa005620.61756912
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61728759
104Dorso-ventral axis formation_Homo sapiens_hsa043200.59594648
105Melanoma_Homo sapiens_hsa052180.59455062
106Insulin signaling pathway_Homo sapiens_hsa049100.59046272
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58436832
108Glucagon signaling pathway_Homo sapiens_hsa049220.58314120
109Herpes simplex infection_Homo sapiens_hsa051680.58254045
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58122129
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57339637
112HIF-1 signaling pathway_Homo sapiens_hsa040660.56839914
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.56741470
114Apoptosis_Homo sapiens_hsa042100.56469277
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.56263971
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55989137
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.55214889
118Pyruvate metabolism_Homo sapiens_hsa006200.54887712
119Toxoplasmosis_Homo sapiens_hsa051450.54845250
120Nucleotide excision repair_Homo sapiens_hsa034200.54539742
121Pentose phosphate pathway_Homo sapiens_hsa000300.54064628
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54028472
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53949027
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53589268
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53534933
126Fatty acid biosynthesis_Homo sapiens_hsa000610.53435658
127TNF signaling pathway_Homo sapiens_hsa046680.52953746
128Melanogenesis_Homo sapiens_hsa049160.52542470
129VEGF signaling pathway_Homo sapiens_hsa043700.52023398
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51722849
131Amoebiasis_Homo sapiens_hsa051460.50243951
132Wnt signaling pathway_Homo sapiens_hsa043100.49882763
133T cell receptor signaling pathway_Homo sapiens_hsa046600.48445407
134Prolactin signaling pathway_Homo sapiens_hsa049170.48067865
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47687476
136Osteoclast differentiation_Homo sapiens_hsa043800.47358291

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