TAF1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.61470329
2metaphase plate congression (GO:0051310)4.66262781
3protein K6-linked ubiquitination (GO:0085020)4.56173629
4piRNA metabolic process (GO:0034587)4.53244564
5replication fork processing (GO:0031297)4.38728788
6CENP-A containing nucleosome assembly (GO:0034080)4.28028936
7DNA replication checkpoint (GO:0000076)4.27154310
8regulation of DNA endoreduplication (GO:0032875)4.26809057
9synapsis (GO:0007129)4.09326753
10chromatin remodeling at centromere (GO:0031055)4.08527965
11DNA double-strand break processing (GO:0000729)4.04274209
12protein localization to kinetochore (GO:0034501)4.04081067
13establishment of chromosome localization (GO:0051303)4.03949204
14attachment of spindle microtubules to kinetochore (GO:0008608)3.92617791
15kinetochore assembly (GO:0051382)3.91323623
16maturation of 5.8S rRNA (GO:0000460)3.78916688
17rRNA modification (GO:0000154)3.78161694
18regulation of spindle organization (GO:0090224)3.76016488
19kinetochore organization (GO:0051383)3.75049488
20DNA synthesis involved in DNA repair (GO:0000731)3.74919175
21histone exchange (GO:0043486)3.71857154
22DNA methylation involved in gamete generation (GO:0043046)3.66849556
23regulation of female gonad development (GO:2000194)3.65496546
24DNA replication-independent nucleosome organization (GO:0034724)3.64221462
25DNA replication-independent nucleosome assembly (GO:0006336)3.64221462
26ribosome assembly (GO:0042255)3.61621944
27centriole replication (GO:0007099)3.60816354
28protein localization to chromosome, centromeric region (GO:0071459)3.60457542
29regulation of double-strand break repair via homologous recombination (GO:0010569)3.59640172
30non-recombinational repair (GO:0000726)3.59056014
31double-strand break repair via nonhomologous end joining (GO:0006303)3.59056014
32microtubule depolymerization (GO:0007019)3.57794948
33ribosome biogenesis (GO:0042254)3.56223070
34DNA damage response, detection of DNA damage (GO:0042769)3.54976158
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.53959787
36rRNA methylation (GO:0031167)3.53031836
37negative regulation of DNA recombination (GO:0045910)3.51604503
38regulation of helicase activity (GO:0051095)3.49688712
39spindle checkpoint (GO:0031577)3.48311545
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47222623
41termination of RNA polymerase III transcription (GO:0006386)3.40090115
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.40090115
43proteasome assembly (GO:0043248)3.38916088
447-methylguanosine mRNA capping (GO:0006370)3.36082449
45RNA capping (GO:0036260)3.34269592
467-methylguanosine RNA capping (GO:0009452)3.34269592
47somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.32354743
48isotype switching (GO:0045190)3.32354743
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.32354743
50mitotic G2/M transition checkpoint (GO:0044818)3.32337793
51meiotic chromosome segregation (GO:0045132)3.31340014
52meiotic cell cycle (GO:0051321)3.28562336
53DNA ligation (GO:0006266)3.27947062
54protein deneddylation (GO:0000338)3.23942703
55histone mRNA metabolic process (GO:0008334)3.23836151
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.23667580
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.22306537
58DNA replication-dependent nucleosome assembly (GO:0006335)3.21046279
59DNA replication-dependent nucleosome organization (GO:0034723)3.21046279
60purine nucleobase biosynthetic process (GO:0009113)3.20862675
61regulation of mitotic spindle checkpoint (GO:1903504)3.19617567
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19617567
63mitotic chromosome condensation (GO:0007076)3.18365669
64DNA deamination (GO:0045006)3.17168716
65sister chromatid segregation (GO:0000819)3.15449141
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14582858
67nucleobase biosynthetic process (GO:0046112)3.12571755
68mitochondrial RNA metabolic process (GO:0000959)3.11999205
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11456805
70DNA catabolic process, exonucleolytic (GO:0000738)3.09967993
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.09222496
72NADH dehydrogenase complex assembly (GO:0010257)3.09222496
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09222496
74mitotic spindle checkpoint (GO:0071174)3.06650863
75axonemal dynein complex assembly (GO:0070286)3.06345760
76regulation of centriole replication (GO:0046599)3.05288717
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05250760
78* termination of RNA polymerase I transcription (GO:0006363)3.03906721
79RNA-dependent DNA replication (GO:0006278)3.03651982
80transcription elongation from RNA polymerase II promoter (GO:0006368)3.03592417
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03299558
82recombinational repair (GO:0000725)3.02715910
83double-strand break repair via homologous recombination (GO:0000724)3.01847838
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01833330
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.01564790
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01564790
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01564790
88negative regulation of sister chromatid segregation (GO:0033046)3.01564790
89female gamete generation (GO:0007292)3.00257958
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99299461
91mitotic G2 DNA damage checkpoint (GO:0007095)2.99253768
92negative regulation of chromosome segregation (GO:0051985)2.99242799
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.99078092
94negative regulation of DNA-templated transcription, elongation (GO:0032785)2.99078092
95negative regulation of meiosis (GO:0045835)2.98765343
96somatic diversification of immunoglobulins (GO:0016445)2.98690784
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98422092
98telomere maintenance via recombination (GO:0000722)2.97803378
99DNA replication initiation (GO:0006270)2.97596727
100reciprocal meiotic recombination (GO:0007131)2.94123320
101reciprocal DNA recombination (GO:0035825)2.94123320
102spindle assembly checkpoint (GO:0071173)2.93985165
103* DNA-templated transcription, elongation (GO:0006354)2.93983736
104regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93046545
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93029249
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.93029249
107mitotic spindle assembly checkpoint (GO:0007094)2.92766120
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91974294
109telomere maintenance via semi-conservative replication (GO:0032201)2.91333103
110regulation of meiosis I (GO:0060631)2.91168654
111mitotic sister chromatid segregation (GO:0000070)2.90383894
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90311398
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90311398
114positive regulation of mitotic sister chromatid separation (GO:1901970)2.90311398
115regulation of sister chromatid segregation (GO:0033045)2.89613597
116regulation of mitotic sister chromatid separation (GO:0010965)2.89613597
117regulation of mitotic sister chromatid segregation (GO:0033047)2.89613597
118* transcription elongation from RNA polymerase I promoter (GO:0006362)2.88906357
119spliceosomal snRNP assembly (GO:0000387)2.88470517
120somatic recombination of immunoglobulin gene segments (GO:0016447)2.88058685
121positive regulation of chromosome segregation (GO:0051984)2.88049076
122protein complex biogenesis (GO:0070271)2.87568244
123regulation of mitotic spindle organization (GO:0060236)2.86913438
124transcription from mitochondrial promoter (GO:0006390)2.86597129
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85438118
126multicellular organism reproduction (GO:0032504)2.85099323
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84645664
128DNA-dependent DNA replication (GO:0006261)2.84633077
129mitochondrial respiratory chain complex assembly (GO:0033108)2.83706043
130* transcription from RNA polymerase I promoter (GO:0006360)2.82197133
131base-excision repair, AP site formation (GO:0006285)2.82007943
132cullin deneddylation (GO:0010388)2.81600907
133transcription-coupled nucleotide-excision repair (GO:0006283)2.81472334
134DNA strand elongation involved in DNA replication (GO:0006271)2.81373039
135male meiosis (GO:0007140)2.80857844
136RNA methylation (GO:0001510)2.80796294
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80523097
138mitotic nuclear envelope disassembly (GO:0007077)2.80021024
139telomere maintenance via telomerase (GO:0007004)2.79570390
140regulation of chromosome segregation (GO:0051983)2.79111135
141negative regulation of smooth muscle cell differentiation (GO:0051151)2.78715279
142centriole assembly (GO:0098534)2.78698107
143protein localization to chromosome (GO:0034502)2.78437686
144establishment of integrated proviral latency (GO:0075713)2.77891642
145DNA strand elongation (GO:0022616)2.76080893
146positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75788275
147mitotic recombination (GO:0006312)2.74202483
148oocyte maturation (GO:0001556)2.73907771
149somatic diversification of immune receptors (GO:0002200)2.73327730
150intra-S DNA damage checkpoint (GO:0031573)2.72613824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00670542
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29638857
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44629995
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31163522
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.22487358
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14344184
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.13992708
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.97855095
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.91257225
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81773973
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69850750
12ZNF274_21170338_ChIP-Seq_K562_Hela2.69631539
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62193702
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.52768992
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.48707687
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.44892350
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37956099
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25702761
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.22993215
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22736756
21VDR_23849224_ChIP-Seq_CD4+_Human2.18764646
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11992517
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10569267
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09110389
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04316657
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98659700
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95779270
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95258058
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94243381
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91602875
31FOXP3_21729870_ChIP-Seq_TREG_Human1.87853329
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86001995
33AR_21909140_ChIP-Seq_LNCAP_Human1.85352462
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.83562347
35* ELK1_19687146_ChIP-ChIP_HELA_Human1.83407166
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.80622267
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78441798
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75850373
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74704847
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.72820614
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72136745
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66851977
43* NOTCH1_21737748_ChIP-Seq_TLL_Human1.62272370
44GABP_19822575_ChIP-Seq_HepG2_Human1.60165367
45TTF2_22483619_ChIP-Seq_HELA_Human1.60149013
46TAF15_26573619_Chip-Seq_HEK293_Human1.56939897
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.54805720
48* P300_19829295_ChIP-Seq_ESCs_Human1.53922156
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49313029
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48882884
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48712157
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45634334
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45633220
54DCP1A_22483619_ChIP-Seq_HELA_Human1.45536716
55ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.42731675
56MYC_18940864_ChIP-ChIP_HL60_Human1.41078741
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40235885
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38832757
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.38586931
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35250817
61IRF1_19129219_ChIP-ChIP_H3396_Human1.30586606
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28216347
63XRN2_22483619_ChIP-Seq_HELA_Human1.28102726
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27010108
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24244913
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23458220
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23042771
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22859576
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22167361
70GBX2_23144817_ChIP-Seq_PC3_Human1.21669655
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19785135
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15678228
73EWS_26573619_Chip-Seq_HEK293_Human1.14322238
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.14310923
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12735106
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12695960
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11530577
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11177092
79ER_23166858_ChIP-Seq_MCF-7_Human1.10000861
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08797334
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06987262
82CBP_20019798_ChIP-Seq_JUKART_Human1.06668965
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06668965
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06438001
85TP53_22573176_ChIP-Seq_HFKS_Human1.06028796
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04282451
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03738877
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02585109
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.02485134
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99293474
91FUS_26573619_Chip-Seq_HEK293_Human0.98487562
92CIITA_25753668_ChIP-Seq_RAJI_Human0.98352963
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.97382817
94VDR_22108803_ChIP-Seq_LS180_Human0.96193083
95NMYC_18555785_Chip-Seq_ESCs_Mouse0.95558524
96KLF4_18555785_Chip-Seq_ESCs_Mouse0.95129474
97RNF2_27304074_Chip-Seq_NSC_Mouse0.95095870
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94787825
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94226432
100ZFX_18555785_Chip-Seq_ESCs_Mouse0.92751343
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91803055
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91169428
103RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90482915
104LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90358399
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.90277095
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90045211
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89583016
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89555062
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88762936
110IGF1R_20145208_ChIP-Seq_DFB_Human0.88285315
111SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88028626
112OCT4_18555785_Chip-Seq_ESCs_Mouse0.87642151
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87630103
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87098896
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86763485
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86558272
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86547076
118SOX2_18555785_Chip-Seq_ESCs_Mouse0.85437768
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84876757
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84851282
121* ELK1_22589737_ChIP-Seq_MCF10A_Human0.84295382
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.84158985
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82279549
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80809856
125CRX_20693478_ChIP-Seq_RETINA_Mouse0.80757995
126P53_22387025_ChIP-Seq_ESCs_Mouse0.80574477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.13594852
2MP0010094_abnormal_chromosome_stability4.22957945
3MP0003111_abnormal_nucleus_morphology3.91336416
4MP0003718_maternal_effect3.82581664
5MP0008057_abnormal_DNA_replication3.55002736
6MP0008877_abnormal_DNA_methylation3.54591602
7MP0008058_abnormal_DNA_repair3.43169904
8MP0006292_abnormal_olfactory_placode3.35442309
9MP0003077_abnormal_cell_cycle3.00506961
10MP0001188_hyperpigmentation2.85818214
11MP0004957_abnormal_blastocyst_morpholog2.78393834
12MP0008932_abnormal_embryonic_tissue2.34297850
13MP0000372_irregular_coat_pigmentation2.25877704
14MP0003941_abnormal_skin_development2.23851487
15MP0008007_abnormal_cellular_replicative2.10968714
16MP0003786_premature_aging2.10558129
17MP0008260_abnormal_autophagy2.02791437
18MP0003787_abnormal_imprinting2.02682216
19MP0000566_synostosis1.83798168
20MP0001984_abnormal_olfaction1.82259300
21MP0001293_anophthalmia1.75665888
22MP0009697_abnormal_copulation1.75182264
23MP0001119_abnormal_female_reproductive1.74002127
24MP0001929_abnormal_gametogenesis1.70591913
25MP0003567_abnormal_fetal_cardiomyocyte1.70559282
26MP0002210_abnormal_sex_determination1.69554396
27MP0002163_abnormal_gland_morphology1.68308816
28MP0005253_abnormal_eye_physiology1.66905846
29MP0000015_abnormal_ear_pigmentation1.60627121
30MP0006072_abnormal_retinal_apoptosis1.57829205
31MP0005451_abnormal_body_composition1.55642950
32MP0003136_yellow_coat_color1.52304436
33MP0003121_genomic_imprinting1.51610908
34MP0003123_paternal_imprinting1.46243732
35MP0000653_abnormal_sex_gland1.44435205
36MP0001986_abnormal_taste_sensitivity1.43217351
37MP0003763_abnormal_thymus_physiology1.38454918
38MP0001919_abnormal_reproductive_system1.35934645
39MP0002234_abnormal_pharynx_morphology1.32813042
40MP0005395_other_phenotype1.30128615
41MP0005389_reproductive_system_phenotype1.29654071
42MP0002249_abnormal_larynx_morphology1.27562154
43MP0003699_abnormal_female_reproductive1.27275871
44MP0003119_abnormal_digestive_system1.27117435
45MP0005551_abnormal_eye_electrophysiolog1.24619453
46MP0002736_abnormal_nociception_after1.22419966
47MP0004381_abnormal_hair_follicle1.22215189
48MP0002102_abnormal_ear_morphology1.20454909
49MP0003315_abnormal_perineum_morphology1.20376447
50MP0003646_muscle_fatigue1.19986480
51MP0006035_abnormal_mitochondrial_morpho1.19321349
52MP0002132_abnormal_respiratory_system1.19154027
53MP0000350_abnormal_cell_proliferation1.18644042
54MP0003011_delayed_dark_adaptation1.18566515
55MP0001145_abnormal_male_reproductive1.18256210
56MP0004133_heterotaxia1.17620457
57MP0002095_abnormal_skin_pigmentation1.14784675
58MP0000631_abnormal_neuroendocrine_gland1.12761995
59MP0001730_embryonic_growth_arrest1.12192128
60MP0000427_abnormal_hair_cycle1.10704555
61MP0005380_embryogenesis_phenotype1.10077950
62MP0001672_abnormal_embryogenesis/_devel1.10077950
63MP0010307_abnormal_tumor_latency1.08307810
64MP0005391_vision/eye_phenotype1.07931750
65MP0002233_abnormal_nose_morphology1.07840589
66MP0002396_abnormal_hematopoietic_system1.07631763
67MP0005379_endocrine/exocrine_gland_phen1.07117520
68MP0003937_abnormal_limbs/digits/tail_de1.05933503
69MP0003186_abnormal_redox_activity1.05536568
70MP0008995_early_reproductive_senescence1.05394472
71MP0002160_abnormal_reproductive_system1.04192670
72MP0006036_abnormal_mitochondrial_physio1.04001715
73MP0003880_abnormal_central_pattern1.03751632
74MP0000678_abnormal_parathyroid_gland1.03054840
75MP0002085_abnormal_embryonic_tissue0.98820341
76MP0000647_abnormal_sebaceous_gland0.96745097
77MP0008789_abnormal_olfactory_epithelium0.95751246
78MP0003195_calcinosis0.95712171
79MP0002277_abnormal_respiratory_mucosa0.95074534
80MP0002177_abnormal_outer_ear0.94978016
81MP0000490_abnormal_crypts_of0.93743416
82MP0000569_abnormal_digit_pigmentation0.93702949
83MP0001324_abnormal_eye_pigmentation0.92821706
84MP0002653_abnormal_ependyma_morphology0.92316065
85MP0003698_abnormal_male_reproductive0.89881678
86MP0004147_increased_porphyrin_level0.88253583
87MP0004197_abnormal_fetal_growth/weight/0.87574731
88MP0000762_abnormal_tongue_morphology0.86633928
89MP0003890_abnormal_embryonic-extraembry0.86424580
90MP0002009_preneoplasia0.85969191
91MP0000579_abnormal_nail_morphology0.85667417
92MP0009333_abnormal_splenocyte_physiolog0.82990984
93MP0002938_white_spotting0.82321040
94MP0002161_abnormal_fertility/fecundity0.82074834
95MP0003950_abnormal_plasma_membrane0.81837422
96MP0003938_abnormal_ear_development0.80979562
97MP0000313_abnormal_cell_death0.80945605
98MP0003984_embryonic_growth_retardation0.80674081
99MP0002638_abnormal_pupillary_reflex0.80339067
100MP0001697_abnormal_embryo_size0.80177544
101MP0002019_abnormal_tumor_incidence0.79885024
102MP0001529_abnormal_vocalization0.79738893
103MP0000049_abnormal_middle_ear0.79118179
104MP0002751_abnormal_autonomic_nervous0.78716868
105MP0001286_abnormal_eye_development0.76295126
106MP0003755_abnormal_palate_morphology0.75919945
107MP0005195_abnormal_posterior_eye0.75195140
108MP0003806_abnormal_nucleotide_metabolis0.75133184
109MP0002088_abnormal_embryonic_growth/wei0.74935831
110MP0005646_abnormal_pituitary_gland0.74481107
111MP0000026_abnormal_inner_ear0.73989682
112MP0004782_abnormal_surfactant_physiolog0.73290447
113MP0005386_behavior/neurological_phenoty0.73268048
114MP0004924_abnormal_behavior0.73268048
115MP0005075_abnormal_melanosome_morpholog0.73016052
116MP0000613_abnormal_salivary_gland0.72627142
117MP0001485_abnormal_pinna_reflex0.71998505
118MP0002084_abnormal_developmental_patter0.71885603
119MP0001968_abnormal_touch/_nociception0.69384604
120MP0005171_absent_coat_pigmentation0.69251614
121MP0005647_abnormal_sex_gland0.69037583
122MP0001764_abnormal_homeostasis0.68509789
123MP0005499_abnormal_olfactory_system0.68474673
124MP0005394_taste/olfaction_phenotype0.68474673
125MP0009703_decreased_birth_body0.68345296
126MP0000432_abnormal_head_morphology0.67734647
127MP0004142_abnormal_muscle_tone0.67503199
128MP0006276_abnormal_autonomic_nervous0.67386563
129MP0002127_abnormal_cardiovascular_syste0.67357566
130MP0000778_abnormal_nervous_system0.66866913
131MP0010030_abnormal_orbit_morphology0.66171702
132MP0005084_abnormal_gallbladder_morpholo0.65933638
133MP0004742_abnormal_vestibular_system0.65829699
134MP0004808_abnormal_hematopoietic_stem0.64953180
135MP0003861_abnormal_nervous_system0.64064218
136MP0002080_prenatal_lethality0.62498327
137MP0001186_pigmentation_phenotype0.61592712
138MP0005174_abnormal_tail_pigmentation0.59808488
139MP0005408_hypopigmentation0.59104546

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.49105685
2Chromsome breakage (HP:0040012)5.15940998
3Birth length less than 3rd percentile (HP:0003561)4.06937793
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.71358941
5Volvulus (HP:0002580)3.70756182
6Breast hypoplasia (HP:0003187)3.54536511
7Abnormality of the preputium (HP:0100587)3.53621218
8Abnormality of the renal collecting system (HP:0004742)3.43984327
9Duplicated collecting system (HP:0000081)3.39568273
10Meckel diverticulum (HP:0002245)3.18475378
11Pancreatic fibrosis (HP:0100732)3.18359322
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.06909343
13Abnormality of the ileum (HP:0001549)3.03448039
14Abnormality of chromosome stability (HP:0003220)3.02447302
15Premature ovarian failure (HP:0008209)2.92090194
16Patellar aplasia (HP:0006443)2.87214952
17Absent radius (HP:0003974)2.86068525
18Ectopic kidney (HP:0000086)2.84174128
19Acute necrotizing encephalopathy (HP:0006965)2.76547053
20Acute encephalopathy (HP:0006846)2.72338380
21Bifid tongue (HP:0010297)2.67795875
22Aplasia/Hypoplasia of the patella (HP:0006498)2.66196011
23Aplasia involving forearm bones (HP:0009822)2.65359975
24Absent forearm bone (HP:0003953)2.65359975
25Colon cancer (HP:0003003)2.64596018
26Supernumerary spleens (HP:0009799)2.63250438
27True hermaphroditism (HP:0010459)2.60752833
28Progressive macrocephaly (HP:0004481)2.59594980
29Abnormal respiratory motile cilium physiology (HP:0012261)2.59482974
30Abnormality of the labia minora (HP:0012880)2.57410364
31Duodenal stenosis (HP:0100867)2.56606160
32Small intestinal stenosis (HP:0012848)2.56606160
33Methylmalonic acidemia (HP:0002912)2.51618944
34Lip pit (HP:0100267)2.47234696
35Cerebral hypomyelination (HP:0006808)2.46476950
36Neoplasm of the adrenal cortex (HP:0100641)2.43850639
37Hypergonadotropic hypogonadism (HP:0000815)2.43200747
38Pancreatic cysts (HP:0001737)2.42817611
39Abnormal biliary tract physiology (HP:0012439)2.41905517
40Bile duct proliferation (HP:0001408)2.41905517
41Septo-optic dysplasia (HP:0100842)2.39884557
42Secondary amenorrhea (HP:0000869)2.39017317
43Nephroblastoma (Wilms tumor) (HP:0002667)2.37997261
44Increased CSF lactate (HP:0002490)2.37502610
45Abnormality of DNA repair (HP:0003254)2.37253642
46Carpal bone hypoplasia (HP:0001498)2.37017813
47Abnormal mitochondria in muscle tissue (HP:0008316)2.32500181
48Embryonal renal neoplasm (HP:0011794)2.28732865
49Mitochondrial inheritance (HP:0001427)2.27654187
50Sloping forehead (HP:0000340)2.27625470
51Increased hepatocellular lipid droplets (HP:0006565)2.27444050
52Abnormal ciliary motility (HP:0012262)2.27126169
53Abnormal respiratory motile cilium morphology (HP:0005938)2.25924917
54Abnormal respiratory epithelium morphology (HP:0012253)2.25924917
55Horseshoe kidney (HP:0000085)2.25252792
56Impulsivity (HP:0100710)2.24003785
57Bone marrow hypocellularity (HP:0005528)2.21096226
58Oligodactyly (hands) (HP:0001180)2.19636162
59Progressive inability to walk (HP:0002505)2.17021893
60Hypoplasia of the pons (HP:0012110)2.15348497
61Irregular epiphyses (HP:0010582)2.15131338
62Short thumb (HP:0009778)2.13693842
63Limb hypertonia (HP:0002509)2.12721791
64Hyperglycinemia (HP:0002154)2.12688180
65Abnormality of the renal medulla (HP:0100957)2.12115832
66Ureteral duplication (HP:0000073)2.11903611
67Abnormality of the pons (HP:0007361)2.11359775
68Facial cleft (HP:0002006)2.10473824
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.09691067
70Absent/shortened dynein arms (HP:0200106)2.09691067
71Reticulocytopenia (HP:0001896)2.08437066
72Rhabdomyosarcoma (HP:0002859)2.05964432
73Clubbing of toes (HP:0100760)2.05792099
74Myelodysplasia (HP:0002863)2.05644959
75Cerebral edema (HP:0002181)2.05341360
76Intestinal atresia (HP:0011100)2.05273550
77Abnormality of the duodenum (HP:0002246)2.04097192
78Flat capital femoral epiphysis (HP:0003370)2.02590474
79Rough bone trabeculation (HP:0100670)2.02151033
80Lipid accumulation in hepatocytes (HP:0006561)2.01974273
81Nephronophthisis (HP:0000090)2.01295354
82Gaze-evoked nystagmus (HP:0000640)2.01181520
83Methylmalonic aciduria (HP:0012120)2.00454552
84Papillary thyroid carcinoma (HP:0002895)1.98588557
85Chronic bronchitis (HP:0004469)1.97724667
86Abnormal sex determination (HP:0012244)1.97606874
87Sex reversal (HP:0012245)1.97606874
88Abnormality of midbrain morphology (HP:0002418)1.97500758
89Molar tooth sign on MRI (HP:0002419)1.97500758
90Entropion (HP:0000621)1.97474277
91Triphalangeal thumb (HP:0001199)1.96523307
92Neoplasm of the adrenal gland (HP:0100631)1.95654002
93Median cleft lip (HP:0000161)1.95505109
94Type I transferrin isoform profile (HP:0003642)1.94434326
95Prostate neoplasm (HP:0100787)1.93899042
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.93683804
97Medial flaring of the eyebrow (HP:0010747)1.93109784
98Abnormality of the carotid arteries (HP:0005344)1.92966346
99Abnormal lung lobation (HP:0002101)1.91994102
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.91422536
101Astigmatism (HP:0000483)1.91286966
102Preaxial hand polydactyly (HP:0001177)1.90159436
103Hypoplasia of the fovea (HP:0007750)1.89994832
104Aplasia/Hypoplasia of the fovea (HP:0008060)1.89994832
105Absent thumb (HP:0009777)1.89427506
106Aplastic anemia (HP:0001915)1.88425954
107Anal stenosis (HP:0002025)1.87005005
108Oculomotor apraxia (HP:0000657)1.86844220
109Dandy-Walker malformation (HP:0001305)1.85943281
110Rhinitis (HP:0012384)1.85523401
111Oligohydramnios (HP:0001562)1.84764882
112Hypoplastic pelvis (HP:0008839)1.84560166
113Nephrogenic diabetes insipidus (HP:0009806)1.84200143
114Ependymoma (HP:0002888)1.83300907
115Bronchiectasis (HP:0002110)1.81537750
116Atelectasis (HP:0100750)1.81464908
117Abolished electroretinogram (ERG) (HP:0000550)1.81416055
118Genu varum (HP:0002970)1.81344997
119Adrenal hypoplasia (HP:0000835)1.81201630
120Cortical dysplasia (HP:0002539)1.80987904
121Small hand (HP:0200055)1.80973339
122Pendular nystagmus (HP:0012043)1.80943659
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80912274
124Male pseudohermaphroditism (HP:0000037)1.79249902
125Congenital primary aphakia (HP:0007707)1.79238917
126Dyschromatopsia (HP:0007641)1.78285619
127Increased serum lactate (HP:0002151)1.78102263
128Abnormal spermatogenesis (HP:0008669)1.77763878
129Abnormality of serine family amino acid metabolism (HP:0010894)1.77377318
130Abnormality of glycine metabolism (HP:0010895)1.77377318
131Aganglionic megacolon (HP:0002251)1.76974584
132Gonadotropin excess (HP:0000837)1.76875793
133Sclerocornea (HP:0000647)1.76786804
134Distal lower limb muscle weakness (HP:0009053)1.74893787
135Abnormality of serum amino acid levels (HP:0003112)1.74299293
136Abnormality of the fovea (HP:0000493)1.73373977
137Type II lissencephaly (HP:0007260)1.73090832
138Optic nerve hypoplasia (HP:0000609)1.72505057
139Abnormality of the septum pellucidum (HP:0007375)1.71682915
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.71643615
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71534931
142Sparse lateral eyebrow (HP:0005338)1.70446728
143Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70412884
144Postaxial foot polydactyly (HP:0001830)1.70387646
145Genital tract atresia (HP:0001827)1.70019615
146Poor coordination (HP:0002370)1.69495130
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69380289
148Abnormality of alanine metabolism (HP:0010916)1.69380289
149Hyperalaninemia (HP:0003348)1.69380289
150Hyperventilation (HP:0002883)1.67675667
151Abnormality of the fingertips (HP:0001211)1.66810563
152Osteomalacia (HP:0002749)1.65627724
153Congenital stationary night blindness (HP:0007642)1.65368988
154Abnormality of the anterior horn cell (HP:0006802)1.65341310
155Degeneration of anterior horn cells (HP:0002398)1.65341310
156Oral leukoplakia (HP:0002745)1.64860318
157Gait imbalance (HP:0002141)1.64355594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.54658358
2PLK43.48671438
3TTK3.35068759
4BUB13.26324890
5TRIM283.07989668
6PBK2.93279468
7ZAK2.85812370
8STK162.75862643
9FRK2.62420962
10STK38L2.59410252
11CDC72.44880438
12NEK12.37687042
13BMPR22.30365700
14AKT32.26837495
15WNK32.21133821
16WEE12.20777558
17IRAK32.20329693
18ACVR1B2.11395750
19EIF2AK12.08024906
20VRK12.07234044
21CHEK21.95633915
22MAP4K21.94442033
23PLK31.92677817
24PLK11.92065723
25BRSK21.92001865
26CDK81.89365569
27EIF2AK31.65028729
28BRAF1.59594119
29MKNK21.58610970
30TSSK61.57192400
31BCR1.51837623
32MKNK11.49458315
33MAP3K61.41368408
34TNIK1.39447403
35EIF2AK21.38632047
36GRK11.36441332
37NEK21.34710689
38ATR1.29299299
39AURKB1.27769377
40TAF11.27607960
41CASK1.27244193
42MAP3K41.25378533
43VRK21.22555976
44DYRK31.21556798
45MELK1.17077519
46AURKA1.15041172
47MUSK1.11463019
48TXK1.03568482
49CSNK1G11.03534129
50NLK1.00747024
51CDK70.99943012
52BMPR1B0.97837020
53CDK30.97825100
54CHEK10.97188570
55CSNK1G20.94602279
56ATM0.93541922
57ERBB30.93338223
58TAOK30.92489937
59DYRK20.90617826
60CSNK1G30.89719817
61IRAK40.88578516
62LATS20.88235383
63CCNB10.84317260
64NEK60.83517003
65STK240.83344658
66CSNK1A1L0.81838243
67NME10.79865233
68MAP2K70.77502925
69SIK30.75856596
70EPHA20.75799172
71BRD40.75115646
72CDK90.74595668
73STK100.71488546
74PLK20.70745350
75IRAK20.65597531
76TGFBR10.65175341
77PDK20.64944666
78BRSK10.64744338
79TEC0.63825572
80MAPK130.63539315
81MAPKAPK30.63398917
82PRKCI0.61335328
83RPS6KA50.60359881
84TRPM70.59344461
85LATS10.59022070
86MAPK150.57517370
87MAPKAPK50.57101881
88SGK20.55451390
89CDK20.55102596
90CDK40.54352615
91CDK10.53558506
92RPS6KA40.52584395
93OXSR10.52385514
94TLK10.50805077
95PIM10.49962585
96CSNK2A10.49831016
97MOS0.49804244
98STK390.48780787
99CSNK1E0.47274337
100NUAK10.47258399
101ADRBK20.46672388
102INSRR0.46344973
103PINK10.46241718
104STK30.45970234
105RPS6KB20.44639400
106CSNK1D0.44272729
107EPHA30.41938694
108STK40.41421057
109PASK0.41305296
110MST40.40660541
111CSNK2A20.40418665
112IRAK10.40393261
113PRKCG0.39243952
114CHUK0.38978846
115CLK10.38541480
116DYRK1A0.38187201
117ERBB40.38042459
118PRKCE0.37486815
119MAP3K50.36146126
120MAP3K140.35303307
121PNCK0.35060500
122PRKDC0.34852694
123MAP3K80.33802638
124CSNK1A10.33321933
125ADRBK10.32603839
126DAPK10.32190272
127MAP3K120.30497714
128WNK40.29529947
129MAP3K30.28815153
130ALK0.28574806
131ERBB20.27471985
132FGFR10.24432847

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.22768748
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.91770722
3Fanconi anemia pathway_Homo sapiens_hsa034603.65693278
4Homologous recombination_Homo sapiens_hsa034403.57826539
5Basal transcription factors_Homo sapiens_hsa030223.39059587
6DNA replication_Homo sapiens_hsa030303.33679215
7Mismatch repair_Homo sapiens_hsa034303.33280808
8Cell cycle_Homo sapiens_hsa041102.77684203
9RNA transport_Homo sapiens_hsa030132.76595131
10Non-homologous end-joining_Homo sapiens_hsa034502.60044707
11Base excision repair_Homo sapiens_hsa034102.59552463
12RNA degradation_Homo sapiens_hsa030182.56462899
13Vitamin B6 metabolism_Homo sapiens_hsa007502.56181872
14Pyrimidine metabolism_Homo sapiens_hsa002402.49663988
15Nucleotide excision repair_Homo sapiens_hsa034202.48700076
16Spliceosome_Homo sapiens_hsa030402.42556944
17Proteasome_Homo sapiens_hsa030502.22818894
18Protein export_Homo sapiens_hsa030602.03140079
19Propanoate metabolism_Homo sapiens_hsa006401.90532262
20Purine metabolism_Homo sapiens_hsa002301.88754578
21mRNA surveillance pathway_Homo sapiens_hsa030151.80746611
22p53 signaling pathway_Homo sapiens_hsa041151.65500344
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50381222
24One carbon pool by folate_Homo sapiens_hsa006701.46775283
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44861614
26Ribosome_Homo sapiens_hsa030101.43070836
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35380711
28Selenocompound metabolism_Homo sapiens_hsa004501.26355588
29Circadian rhythm_Homo sapiens_hsa047101.25922129
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25226272
31Regulation of autophagy_Homo sapiens_hsa041401.22122609
32Steroid biosynthesis_Homo sapiens_hsa001001.20327736
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14298234
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13236497
35Epstein-Barr virus infection_Homo sapiens_hsa051691.06878933
36Pyruvate metabolism_Homo sapiens_hsa006201.04787402
37Oocyte meiosis_Homo sapiens_hsa041141.03818532
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01646185
39Sphingolipid metabolism_Homo sapiens_hsa006001.01081927
40Phototransduction_Homo sapiens_hsa047441.00399562
41Arachidonic acid metabolism_Homo sapiens_hsa005900.99762089
42Fatty acid elongation_Homo sapiens_hsa000620.94908519
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89395170
44Huntingtons disease_Homo sapiens_hsa050160.89031463
45Linoleic acid metabolism_Homo sapiens_hsa005910.88748540
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84902713
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84328835
48Caffeine metabolism_Homo sapiens_hsa002320.80348784
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77941985
50Herpes simplex infection_Homo sapiens_hsa051680.77355611
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76324416
52Butanoate metabolism_Homo sapiens_hsa006500.74643249
53Glutathione metabolism_Homo sapiens_hsa004800.72925982
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71201198
55Primary immunodeficiency_Homo sapiens_hsa053400.70144529
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69797355
57Sulfur metabolism_Homo sapiens_hsa009200.67891302
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67699275
59Ovarian steroidogenesis_Homo sapiens_hsa049130.64845402
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.62859207
61Other glycan degradation_Homo sapiens_hsa005110.58202621
62Olfactory transduction_Homo sapiens_hsa047400.57951228
63HTLV-I infection_Homo sapiens_hsa051660.55862297
64Autoimmune thyroid disease_Homo sapiens_hsa053200.55393895
65Folate biosynthesis_Homo sapiens_hsa007900.54758682
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54028762
67Oxidative phosphorylation_Homo sapiens_hsa001900.53455866
68TGF-beta signaling pathway_Homo sapiens_hsa043500.50870348
69beta-Alanine metabolism_Homo sapiens_hsa004100.50827570
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50058244
71Peroxisome_Homo sapiens_hsa041460.49983156
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.49948810
73Tryptophan metabolism_Homo sapiens_hsa003800.49067652
74Ether lipid metabolism_Homo sapiens_hsa005650.49007701
75MicroRNAs in cancer_Homo sapiens_hsa052060.48469373
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46659669
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.43373135
78Allograft rejection_Homo sapiens_hsa053300.41438644
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40533341
80Thyroid cancer_Homo sapiens_hsa052160.40530383
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39995409
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39293610
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39180691
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.37616928
85Viral carcinogenesis_Homo sapiens_hsa052030.36297839
86N-Glycan biosynthesis_Homo sapiens_hsa005100.36215590
87Nitrogen metabolism_Homo sapiens_hsa009100.36031039
88Fatty acid metabolism_Homo sapiens_hsa012120.35745718
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35734083
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35706994
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35323066
92Parkinsons disease_Homo sapiens_hsa050120.34707013
93Fatty acid degradation_Homo sapiens_hsa000710.33363584
94Hedgehog signaling pathway_Homo sapiens_hsa043400.33238265
95Asthma_Homo sapiens_hsa053100.32650541
96Hematopoietic cell lineage_Homo sapiens_hsa046400.32012097
97Metabolic pathways_Homo sapiens_hsa011000.31597674
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.31426959
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31041941
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.29594609
101FoxO signaling pathway_Homo sapiens_hsa040680.29391801
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29332624
103Carbon metabolism_Homo sapiens_hsa012000.26963503
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26683664
105Wnt signaling pathway_Homo sapiens_hsa043100.25445990
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24906964
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24844445
108Legionellosis_Homo sapiens_hsa051340.24538657
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24314960
110Retinol metabolism_Homo sapiens_hsa008300.24194976
111Chemical carcinogenesis_Homo sapiens_hsa052040.23977961
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23598028
113Basal cell carcinoma_Homo sapiens_hsa052170.22102438
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21888504
115Nicotine addiction_Homo sapiens_hsa050330.21599341
116Hippo signaling pathway_Homo sapiens_hsa043900.21542182
117Antigen processing and presentation_Homo sapiens_hsa046120.20385635
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19720235
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19236889
120Collecting duct acid secretion_Homo sapiens_hsa049660.19171308
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18243294
122Taste transduction_Homo sapiens_hsa047420.18188507
123Glycerolipid metabolism_Homo sapiens_hsa005610.18164207
124Hepatitis B_Homo sapiens_hsa051610.17950652
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16815002
126Measles_Homo sapiens_hsa051620.16518651
127Notch signaling pathway_Homo sapiens_hsa043300.14782738
128Alzheimers disease_Homo sapiens_hsa050100.14477259
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13857444
130Galactose metabolism_Homo sapiens_hsa000520.13792788
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.13759153
132Graft-versus-host disease_Homo sapiens_hsa053320.13522845
133Inositol phosphate metabolism_Homo sapiens_hsa005620.13474813
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.12508314
135Pathways in cancer_Homo sapiens_hsa052000.11565622
136Influenza A_Homo sapiens_hsa051640.11363065
137Vitamin digestion and absorption_Homo sapiens_hsa049770.10949812
138Type I diabetes mellitus_Homo sapiens_hsa049400.10778041
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.09799289
140Pentose phosphate pathway_Homo sapiens_hsa000300.09480702
141Systemic lupus erythematosus_Homo sapiens_hsa053220.08214819

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